Harvard Catalyst Profiles

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Kyle D. Copps, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Feng X, Guan D, Auen T, Choi JW, Salazar-Hernandez MA, Faruk F, Copps KD, Ozcan U. Lipocalin 2 Does Not Play A Role in Celastrol-Mediated Reduction in Food Intake and Body Weight. Sci Rep. 2019 09 05; 9(1):12809. PMID: 31488870.
    Citations:    
  2. Feng X, Guan D, Auen T, Choi JW, Salazar Hernández MA, Lee J, Chun H, Faruk F, Kaplun E, Herbert Z, Copps KD, Ozcan U. IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects. Nat Med. 2019 04; 25(4):575-582. PMID: 30833749.
    Citations:    
  3. Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Publisher Correction: Inactivating hepatic follistatin alleviates hyperglycemia. Nat Med. 2018 Oct; 24(10):1628. PMID: 30111893.
    Citations:    Fields:    
  4. Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Inactivating hepatic follistatin alleviates hyperglycemia. Nat Med. 2018 07; 24(7):1058-1069. PMID: 29867232.
    Citations: 1     Fields:    
  5. Xu H, Lee MS, Tsai PY, Adler AS, Curry NL, Challa S, Freinkman E, Hitchcock DS, Copps KD, White MF, Bronson RT, Marcotrigiano M, Wu Y, Clish CB, Kalaany NY. Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis. Proc Natl Acad Sci U S A. 2018 04 17; 115(16):4228-4233. PMID: 29610318.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Long YC, Cheng Z, Copps KD, White MF. Correction for Long et al., "Insulin Receptor Substrates Irs1 and Irs2 Coordinate Skeletal Muscle Growth and Metabolism via the Akt and AMPK Pathways". Mol Cell Biol. 2017 08 01; 37(15). PMID: 28710120.
    Citations:    Fields:    
  7. Copps KD, Hançer NJ, Qiu W, White MF. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. J Biol Chem. 2016 Apr 15; 291(16):8602-17. PMID: 26846849.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Hançer NJ, Qiu W, Cherella C, Li Y, Copps KD, White MF. Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. J Biol Chem. 2014 May 02; 289(18):12467-84. PMID: 24652289.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  9. Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U. IRS1Ser³°7 phosphorylation does not mediate mTORC1-induced insulin resistance. Biochem Biophys Res Commun. 2014 Jan 10; 443(2):689-93. PMID: 24333417.
    Citations: 5     Fields:    Translation:AnimalsCells
  10. Copps KD, White MF. Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia. 2012 Oct; 55(10):2565-2582. PMID: 22869320.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  11. Matveyenko AV, Liuwantara D, Gurlo T, Kirakossian D, Dalla Man C, Cobelli C, White MF, Copps KD, Volpi E, Fujita S, Butler PC. Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes. 2012 Sep; 61(9):2269-79. PMID: 22688333.
    Citations: 25     Fields:    Translation:AnimalsCells
  12. Long YC, Cheng Z, Copps KD, White MF. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Mol Cell Biol. 2011 Feb; 31(3):430-41. PMID: 21135130.
    Citations: 39     Fields:    Translation:AnimalsCells
  13. Copps KD, Hancer NJ, Opare-Ado L, Qiu W, Walsh C, White MF. Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab. 2010 Jan; 11(1):84-92. PMID: 20074531.
    Citations: 70     Fields:    Translation:AnimalsCells
  14. Sadagurski M, Norquay L, Farhang J, D'Aquino K, Copps K, White MF. Human IL6 enhances leptin action in mice. Diabetologia. 2010 Mar; 53(3):525-35. PMID: 19902173.
    Citations: 34     Fields:    Translation:HumansAnimals
  15. Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med. 2009 Nov; 15(11):1307-11. PMID: 19838201.
    Citations: 92     Fields:    Translation:AnimalsCells
  16. Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV, White MF. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Mol Cell Biol. 2009 Sep; 29(18):5070-83. PMID: 19596788.
    Citations: 50     Fields:    Translation:AnimalsCells
  17. Copps KD, White MF. Breathing room: the (un)natural history of adipose microhypoxia and insulin resistance. Diabetes. 2009 Jan; 58(1):26-7. PMID: 19114728.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008 Jul; 8(1):65-76. PMID: 18590693.
    Citations: 134     Fields:    Translation:AnimalsCells
  19. Giraud J, Haas M, Feener EP, Copps KD, Dong X, Dunn SL, White MF. Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol Endocrinol. 2007 Sep; 21(9):2294-302. PMID: 17579213.
    Citations: 14     Fields:    Translation:AnimalsCells
  20. Dong X, Park S, Lin X, Copps K, Yi X, White MF. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest. 2006 Jan; 116(1):101-14. PMID: 16374520.
    Citations: 56     Fields:    Translation:AnimalsCells
  21. Copps K, Richman R, Lyman LM, Chang KA, Rampersad-Ammons J, Kuroda MI. Complex formation by the Drosophila MSL proteins: role of the MSL2 RING finger in protein complex assembly. EMBO J. 1998 Sep 15; 17(18):5409-17. PMID: 9736618.
    Citations: 52     Fields:    Translation:AnimalsCells
  22. Lyman LM, Copps K, Rastelli L, Kelley RL, Kuroda MI. Drosophila male-specific lethal-2 protein: structure/function analysis and dependence on MSL-1 for chromosome association. Genetics. 1997 Dec; 147(4):1743-53. PMID: 9409833.
    Citations: 67     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.