Harvard Catalyst Profiles

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David Brian Sykes, M.D., Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08CA201640 (SYKES, DAVID B) Apr 1, 2017 - Mar 31, 2021
    NIH/NCI
    Developing differentiation therapy for the treatment of patients with acute myeloid leukemia
    Role: Principal Investigator
  2. R03DA032471 (SYKES, DAVID B) Jul 1, 2011 - Jun 30, 2014
    NIH/NIDA
    Discovering small molecules that overcome differentiation arrest in acute myeloid
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yusuf R, Saez B, Sharda A, van Gastel N, Yu V, Baryawno N, Scadden EW, Acharya SS, Chattophadhyay S, Huang C, Viswanathan V, S'aulis D, Cobert J, Sykes DB, Keibler MA, Das S, Hutchinson JN, Churchill M, Mukherjee S, Lee D, Mercier FE, Doench J, Bullinger L, Logan DJ, Schreiber S, Stephanopoulos G, Rizzo WB, Scadden DT. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood. 2020 May 26. PMID: 32458004.
    Citations:    
  2. Negoro PE, Xu S, Dagher Z, Hopke A, Reedy JL, Feldman MB, Khan NS, Viens AL, Alexander NJ, Atallah NJ, Scherer AK, Dutko RA, Jeffery J, Kernien JF, Fites JS, Nett JE, Klein BS, Vyas JM, Irimia D, Sykes DB, Mansour MK. Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species. mBio. 2020 May 12; 11(3). PMID: 32398316.
    Citations:    
  3. Nguyen GT, Shaban L, Mack M, Swanson KD, Bunnell SC, Sykes DB, Mecsas J. SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst. Elife. 2020 Apr 30; 9. PMID: 32352382.
    Citations:    
  4. Sykes DB, O'Connell C, Schroyens W. The TEMPI syndrome. Blood. 2020 Apr 09; 135(15):1199-1203. PMID: 32108223.
    Citations:    
  5. Sykes DB, Zhang EW, Karp Leaf RS, Nardi V, Turbett SE. Case 10-2020: An 83-Year-Old Man with Pancytopenia and Acute Renal Failure. N Engl J Med. 2020 03 26; 382(13):1258-1266. PMID: 32212524.
    Citations:    
  6. Cabal-Hierro L, van Galen P, Prado MA, Higby KJ, Togami K, Mowery CT, Paulo JA, Xie Y, Cejas P, Furusawa T, Bustin M, Long HW, Sykes DB, Gygi SP, Finley D, Bernstein BE, Lane AA. Chromatin accessibility promotes hematopoietic and leukemia stem cell activity. Nat Commun. 2020 Mar 16; 11(1):1406. PMID: 32179749.
    Citations:    
  7. Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest. 2020 Mar 02; 130(3):1513-1526. PMID: 32065590.
    Citations:    
  8. Jan M, Grinshpun DE, Villalba JA, Dal Cin P, Sykes DB, Iafrate AJ, Ebert BL, Hobbs GS, Nardi V. A cryptic imatinib-sensitive G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia. Blood Adv. 2020 Feb 11; 4(3):445-448. PMID: 31999327.
    Citations:    
  9. Lee S, Micalizzi D, Truesdell SS, Bukhari SIA, Boukhali M, Lombardi-Story J, Kato Y, Choo MK, Dey-Guha I, Ji F, Nicholson BT, Myers DT, Lee D, Mazzola MA, Raheja R, Langenbucher A, Haradhvala NJ, Lawrence MS, Gandhi R, Tiedje C, Diaz-Muñoz MD, Sweetser DA, Sadreyev R, Sykes D, Haas W, Haber DA, Maheswaran S, Vasudevan S. A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. Genome Biol. 2020 02 10; 21(1):33. PMID: 32039742.
    Citations:    
  10. Al-Samkari H, Rosovsky RP, Karp Leaf RS, Smith DB, Goodarzi K, Fogerty AE, Sykes DB, Kuter DJ. A modern reassessment of glycoprotein-specific direct platelet autoantibody testing in immune thrombocytopenia. Blood Adv. 2020 Jan 14; 4(1):9-18. PMID: 31891657.
    Citations:    
  11. Sykes DB. Insights From a Patient With Lung Cancer-Party Therapy Is Way Better Than Chemotherapy. JAMA Oncol. 2019 Sep 12. PMID: 31513260.
    Citations:    
  12. Mann M, Kreuzbauer T, Sykes DB. A man with polycythemia vera, myelodysplastic syndrome and acquired microcytosis. BMJ Case Rep. 2019 Aug 13; 12(8). PMID: 31413051.
    Citations:    
  13. Ameri AH, Curtis BR, Sykes DB. Immune neutropenia mediated by micafungin. Am J Hematol. 2019 07; 94(7):830-832. PMID: 30945326.
    Citations:    
  14. Christian S, Merz C, Evans L, Gradl S, Seidel H, Friberg A, Eheim A, Lejeune P, Brzezinka K, Zimmermann K, Ferrara S, Meyer H, Lesche R, Stoeckigt D, Bauser M, Haegebarth A, Sykes DB, Scadden DT, Losman JA, Janzer A. The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. Leukemia. 2019 10; 33(10):2403-2415. PMID: 30940908.
    Citations:    
  15. Kugadas A, Geddes-McAlister J, Guy E, DiGiandomenico A, Sykes DB, Mansour MK, Mirchev R, Gadjeva M. Frontline Science: Employing enzymatic treatment options for management of ocular biofilm-based infections. J Leukoc Biol. 2019 06; 105(6):1099-1110. PMID: 30690787.
    Citations:    Fields:    
  16. Sykes DB. The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia. Expert Opin Ther Targets. 2018 11; 22(11):893-898. PMID: 30318938.
    Citations:    Fields:    
  17. Garza-Mayers AC, Shah R, Sykes DB, Nigwekar SU, Kroshinsky D. The Successful Use of Apixaban in Dialysis Patients with Calciphylaxis Who Require Anticoagulation: A Retrospective Analysis. Am J Nephrol. 2018; 48(3):168-171. PMID: 30176675.
    Citations:    Fields:    
  18. Lin B, Srikanth P, Castle AC, Nigwekar S, Malhotra R, Galloway JL, Sykes DB, Rajagopal J. Modulating Cell Fate as a Therapeutic Strategy. Cell Stem Cell. 2018 09 06; 23(3):329-341. PMID: 29910150.
    Citations:    Fields:    
  19. Sykes DB, Schroyens W. Complete Responses in the TEMPI Syndrome after Treatment with Daratumumab. N Engl J Med. 2018 06 07; 378(23):2240-2242. PMID: 29874534.
    Citations:    Fields:    Translation:Humans
  20. Fites JS, Gui M, Kernien JF, Negoro P, Dagher Z, Sykes DB, Nett JE, Mansour MK, Klein BS. An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections. PLoS Pathog. 2018 05; 14(5):e1007073. PMID: 29782541.
    Citations:    Fields:    Translation:AnimalsCells
  21. Dagher Z, Xu S, Negoro PE, Khan NS, Feldman MB, Reedy JL, Tam JM, Sykes DB, Mansour MK. Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of Candida glabrata in Macrophages. Front Immunol. 2018; 9:1058. PMID: 29868018.
    Citations:    
  22. Xu S, Feliu M, Lord AK, Lukason DP, Negoro PE, Khan NS, Dagher Z, Feldman MB, Reedy JL, Steiger SN, Tam JM, Soukas AA, Sykes DB, Mansour MK. Biguanides enhance antifungal activity against Candida glabrata. Virulence. 2018; 9(1):1150-1162. PMID: 29962263.
    Citations:    Fields:    Translation:HumansAnimals
  23. Sykes DB, Rosovsky RP, Singhal AB, Gonzalez RG, Moy AP. Case 40-2017. A 32-Year-Old Woman with Headache, Abdominal Pain, Anemia, and Thrombocytopenia. N Engl J Med. 2017 12 28; 377(26):2581-2590. PMID: 29281575.
    Citations:    Fields:    Translation:Humans
  24. Sun L, Sykes DB. Acquired haemophilia A with a recalcitrant high-titre factor VIII inhibitor in the setting of interstitial lung disease. BMJ Case Rep. 2017 Jul 28; 2017. PMID: 28756381.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  25. Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26; 2(11). PMID: 28763796.
    Citations:    Fields:    
  26. Kalaitzidis D, Lee D, Efeyan A, Kfoury Y, Nayyar N, Sykes DB, Mercier FE, Papazian A, Baryawno N, Victora GD, Neuberg D, Sabatini DM, Scadden DT. Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells. J Clin Invest. 2017 Apr 03; 127(4):1405-1413. PMID: 28319048.
    Citations: 2     Fields:    Translation:AnimalsCells
  27. Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J. Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. Nat Med. 2017 01; 23(1):100-106. PMID: 27941791.
    Citations: 22     Fields:    Translation:AnimalsCells
  28. Lewis TA, Sykes DB, Law JM, Muñoz B, Rustiguel JK, Nonato MC, Scadden DT, Schreiber SL. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Dec 08; 7(12):1112-1117. PMID: 27994748.
    Citations: 3     
  29. Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, Eheim AL, Stoeckigt D, Maxcy KL, Cobert JM, Bachand J, Szekely BA, Mukherjee S, Sklar LA, Kotz JD, Clish CB, Sadreyev RI, Clemons PA, Janzer A, Schreiber SL, Scadden DT. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016 Sep 22; 167(1):171-186.e15. PMID: 27641501.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  30. Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nat Biotechnol. 2016 07; 34(7):738-45. PMID: 27272386.
    Citations: 20     Fields:    Translation:AnimalsCells
  31. Mercier FE, Sykes DB, Scadden DT. Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse. Stem Cell Reports. 2016 06 14; 6(6):985-992. PMID: 27185283.
    Citations: 6     Fields:    Translation:AnimalsCells
  32. Lee D, Wang YH, Kalaitzidis D, Ramachandran J, Eda H, Sykes DB, Raje N, Scadden DT. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016 Apr 01; 126(4):1300-10. PMID: 26927669.
    Citations: 3     Fields:    Translation:HumansAnimals
  33. Chen E, Ahn JS, Sykes DB, Breyfogle LJ, Godfrey AL, Nangalia J, Ko A, DeAngelo DJ, Green AR, Mullally A. RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability. Cell Rep. 2015 Dec 22; 13(11):2345-2352. PMID: 26686625.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  34. Kenderian SS, Rosado FG, Sykes DB, Hoyer JD, Lacy MQ. Long-term complete clinical and hematological responses of the TEMPI syndrome after autologous stem cell transplantation. Leukemia. 2015 Dec; 29(12):2414-6. PMID: 26500143.
    Citations:    Fields:    Translation:Humans
  35. Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015 Jul 31; 349(6247):1261669. PMID: 26228159.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  36. Lang D, Mead JS, Sykes DB. Hormones and the bone marrow: panhypopituitarism and pancytopenia in a man with a pituitary adenoma. J Gen Intern Med. 2015 May; 30(5):692-6. PMID: 25583570.
    Citations:    Fields:    Translation:Humans
  37. Belizaire R, Sykes DB, Chen YB, Spitzer TR, Makar RS. Difficulties in hematopoietic progenitor cell collection from a patient with TEMPI syndrome and severe iatrogenic iron deficiency. Transfusion. 2015 Sep; 55(9):2142-8. PMID: 25911963.
    Citations:    Fields:    Translation:HumansCells
  38. Sykes DB, Nichols DN. There Is No Denying It, Our Medical Language Needs an Update. J Grad Med Educ. 2015 Mar; 7(1):137-8. PMID: 26217448.
    Citations:    Fields:    Translation:Humans
  39. Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, Hideshima T, Dancík V, Majireck MM, Hussain MM, Singh S, Quiroz R, Iaconelli J, Karmacharya R, Tolliday NJ, Clemons PA, Moore MAS, Stern AM, Shamji AF, Ebert BL, Golub TR, Raje NS, Scadden DT, Schreiber SL. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Rep. 2015 Feb 10; 10(5):755-770. PMID: 25660025.
    Citations: 6     Fields:    
  40. Gupta S, Fenves A, Nance ST, Sykes DB, Dzik WS. Hyperhemolysis syndrome in a patient without a hemoglobinopathy, unresponsive to treatment with eculizumab. Transfusion. 2015 Mar; 55(3):623-8. PMID: 25257194.
    Citations: 3     Fields:    Translation:Humans
  41. Rosado FG, Oliveira JL, Sohani AR, Schroyens W, Sykes DB, Kenderian SS, Lacy MQ, Kyle RA, Hoyer JD. Bone marrow findings of the newly described TEMPI syndrome: when erythrocytosis and plasma cell dyscrasia coexist. Mod Pathol. 2015 Mar; 28(3):367-72. PMID: 25216227.
    Citations: 2     Fields:    Translation:Humans
  42. Khan J, Sykes DB. Case report: a 37-year-old male with telangiectasias, polycythemia vera, perinephric fluid collections, and intrapulmonary shunting. BMC Hematol. 2014; 14(1):11. PMID: 25143825.
    Citations:    
  43. Wu L, Walas S, Leung W, Sykes DB, Wu J, Lo EH, Lok J. Neuregulin1-ß decreases IL-1ß-induced neutrophil adhesion to human brain microvascular endothelial cells. Transl Stroke Res. 2015 Apr; 6(2):116-24. PMID: 24863743.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  44. Singh H, Lane AA, Correll M, Przychodzen B, Sykes DB, Stone RM, Ballen KK, Amrein PC, Maciejewski J, Attar EC. Putative RNA-splicing gene LUC7L2 on 7q34 represents a candidate gene in pathogenesis of myeloid malignancies. Blood Cancer J. 2013 May 24; 3:e117. PMID: 23708642.
    Citations: 3     Fields:    
  45. Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, Vyas JM. Dectin-1 activation controls maturation of ß-1,3-glucan-containing phagosomes. J Biol Chem. 2013 May 31; 288(22):16043-54. PMID: 23609446.
    Citations: 23     Fields:    Translation:AnimalsCells
  46. Simic P, Zainabadi K, Bell E, Sykes DB, Saez B, Lotinun S, Baron R, Scadden D, Schipani E, Guarente L. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating ß-catenin. EMBO Mol Med. 2013 Mar; 5(3):430-40. PMID: 23364955.
    Citations: 48     Fields:    Translation:AnimalsCells
  47. Schroyens W, O'Connell C, Sykes DB. Complete and partial responses of the TEMPI syndrome to bortezomib. N Engl J Med. 2012 Aug 23; 367(8):778-80. PMID: 22913703.
    Citations: 3     Fields:    Translation:Humans
  48. Park D, Sykes DB, Scadden DT. The hematopoietic stem cell niche. Front Biosci (Landmark Ed). 2012 Jan 01; 17:30-9. PMID: 22201730.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  49. Sykes DB, Schroyens W, O'Connell C. The TEMPI syndrome--a novel multisystem disease. N Engl J Med. 2011 Aug 04; 365(5):475-7. PMID: 21812700.
    Citations: 6     Fields:    Translation:Humans
  50. Scheele JS, Kolanczyk M, Gantert M, Zemojtel T, Dorn A, Sykes DB, Sykes DP, Möbest DC, Kamps MP, Räpple D, Duchniewicz M. The Spt-Ada-Gcn5-acetyltransferase complex interaction motif of E2a is essential for a subset of transcriptional and oncogenic properties of E2a-Pbx1. Leuk Lymphoma. 2009 May; 50(5):816-28. PMID: 19399691.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  51. Odegaard JI, Vats D, Zhang L, Ricardo-Gonzalez R, Smith KL, Sykes DB, Kamps MP, Chawla A. Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages. J Leukoc Biol. 2007 Mar; 81(3):711-9. PMID: 17158607.
    Citations: 10     Fields:    Translation:HumansCells
  52. Wang GG, Calvo KR, Pasillas MP, Sykes DB, Häcker H, Kamps MP. Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat Methods. 2006 Apr; 3(4):287-93. PMID: 16554834.
    Citations: 81     Fields:    Translation:AnimalsCells
  53. Sykes DB, Kamps MP. E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause acute T-lymphoid or myeloid leukemias in mice. Mol Cell Biol. 2004 Feb; 24(3):1256-69. PMID: 14729970.
    Citations: 9     Fields:    Translation:AnimalsCells
  54. Sykes DB, Kamps MP. Estrogen-regulated conditional oncoproteins: tools to address open questions in normal myeloid cell function, normal myeloid differentiation, and the genetic basis of differentiation arrest in myeloid leukemia. Leuk Lymphoma. 2003 Jul; 44(7):1131-9. PMID: 12916864.
    Citations:    Fields:    Translation:HumansAnimalsCells
  55. Sykes DB, Scheele J, Pasillas M, Kamps MP. Transcriptional profiling during the early differentiation of granulocyte and monocyte progenitors controlled by conditional versions of the E2a-Pbx1 oncoprotein. Leuk Lymphoma. 2003 Jul; 44(7):1187-99. PMID: 12916872.
    Citations: 3     Fields:    Translation:HumansCells
  56. Welch JS, Escoubet-Lozach L, Sykes DB, Liddiard K, Greaves DR, Glass CK. TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism. J Biol Chem. 2002 Nov 08; 277(45):42821-9. PMID: 12215441.
    Citations: 82     Fields:    Translation:AnimalsCells
  57. Calvo KR, Sykes DB, Pasillas MP, Kamps MP. Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1. Oncogene. 2002 Jun 20; 21(27):4247-56. PMID: 12082612.
    Citations: 36     Fields:    Translation:AnimalsCells
  58. Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass CK. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell. 2002 Apr 19; 109(2):169-80. PMID: 12007404.
    Citations: 40     Fields:    Translation:AnimalsCells
  59. Calvo KR, Knoepfler PS, Sykes DB, Pasillas MP, Kamps MP. Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13120-5. PMID: 11687616.
    Citations: 34     Fields:    Translation:AnimalsCells
  60. Sykes DB, Kamps MP. Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins. Blood. 2001 Oct 15; 98(8):2308-18. PMID: 11588024.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  61. Knoepfler PS, Sykes DB, Pasillas M, Kamps MP. HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. Oncogene. 2001 Sep 06; 20(39):5440-8. PMID: 11571641.
    Citations: 12     Fields:    Translation:AnimalsCells
  62. Slupsky CM, Sykes DB, Gay GL, Sykes BD. The HoxB1 hexapeptide is a prefolded domain: implications for the Pbx1/Hox interaction. Protein Sci. 2001 Jun; 10(6):1244-53. PMID: 11369863.
    Citations: 7     Fields:    Translation:HumansCells
  63. Calvo KR, Sykes DB, Pasillas M, Kamps MP. Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression. Mol Cell Biol. 2000 May; 20(9):3274-85. PMID: 10757811.
    Citations: 47     Fields:    Translation:AnimalsCells
  64. Mehta N, Hordines J, Sykes D, Doerr RJ, Cohen SA. Low density lipoproteins and Lovastatin modulate the organ-specific transendothelial migration of primary and metastatic human colon adenocarcinoma cell lines in vitro. Clin Exp Metastasis. 1998 Oct; 16(7):587-94. PMID: 9932605.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  65. Parney IF, Petruk KC, Zhang C, Farr-Jones M, Sykes DB, Chang LJ. Granulocyte-macrophage colony-stimulating factor and B7-2 combination immunogene therapy in an allogeneic Hu-PBL-SCID/beige mouse-human glioblastoma multiforme model. Hum Gene Ther. 1997 Jun 10; 8(9):1073-85. PMID: 9189765.
    Citations: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  66. Sykes D, Dewar R, Mohanaruban K, Donovan K, Nicklason F, Thomas DM, Fisher D. Measuring blood pressure in the elderly: does atrial fibrillation increase observer variability? BMJ. 1990 Jan 20; 300(6718):162-3. PMID: 2105795.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  67. Wilson R, Pitt T, Taylor G, Watson D, MacDermot J, Sykes D, Roberts D, Cole P. Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro. J Clin Invest. 1987 Jan; 79(1):221-9. PMID: 3098783.
    Citations: 56     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.