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David Brian Sykes, M.D., Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08CA201640 (SYKES, DAVID B) Apr 1, 2017 - Mar 31, 2021
    NIH
    Developing differentiation therapy for the treatment of patients with acute myeloid leukemia
    Role: Principal Investigator
  2. R03DA032471 (SYKES, DAVID B) Jul 1, 2011 - Jun 30, 2014
    NIH
    Discovering small molecules that overcome differentiation arrest in acute myeloid
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mercier FE, Shi J, Sykes DB, Oki T, Jankovic M, Man CH, Kfoury YS, Miller E, He S, Zhu A, Vasic R, Doench J, Orthwein A, Michor F, Scadden DT. In vivo genome-wide CRISPR screening in murine acute myeloid leukemia uncovers microenvironmental dependencies. Blood Adv. 2022 Sep 13; 6(17):5072-5084. PMID: 35793392.
    Citations:    Fields:    
  2. Wang H, He X, Zhang L, Dong H, Huang F, Xian J, Li M, Chen W, Lu X, Pathak KV, Huang W, Li Z, Zhang L, Nguyen LXT, Yang L, Feng L, Gordon DJ, Zhang J, Pirrotte P, Chen CW, Salhotra A, Kuo YH, Horne D, Marcucci G, Sykes DB, Tiziani S, Jin H, Wang X, Li L. Disruption of dNTP homeostasis by ribonucleotide reductase hyperactivation overcomes AML differentiation blockade. Blood. 2022 06 30; 139(26):3752-3770. PMID: 35439288; PMCID: PMC9247363.
    Citations:    Fields:    Translation:HumansCells
  3. Ko J, Wilkovitsch M, Oh J, Kohler RH, Bolli E, Pittet MJ, Vinegoni C, Sykes DB, Mikula H, Weissleder R, Carlson JCT. Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes. Nat Biotechnol. 2022 Jun 02. PMID: 35654978.
    Citations:    Fields:    
  4. Franklin R, Guo Y, He S, Chen M, Ji F, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco MA, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev RI, Murn J, Volk A, Cheloufi S. Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity. Nat Commun. 2022 04 29; 13(1):2350. PMID: 35487911; PMCID: PMC9054786.
    Citations:    Fields:    Translation:Cells
  5. Sohn J, Milosevic J, Brouse T, Aziz N, Elkhoury J, Wang S, Hauschild A, van Gastel N, Cetinbas M, Tufa SF, Keene DR, Sadreyev RI, Pu WT, Sykes DB. A new murine model of Barth syndrome neutropenia links TAFAZZIN deficiency to increased ER stress-induced apoptosis. Blood Adv. 2022 04 26; 6(8):2557-2577. PMID: 34979560; PMCID: PMC9043941.
    Citations:    Fields:    Translation:HumansAnimals
  6. Sykes DB, Martinelli MM, Negoro P, Xu S, Maxcy K, Timmer K, Viens AL, Alexander NJ, Atallah J, Snarr BD, Baistrocchi SR, Atallah NJ, Hopke A, Scherer A, Rosales I, Irimia D, Sheppard DC, Mansour MK. Transfusable neutrophil progenitors as cellular therapy for the prevention of invasive fungal infections. J Leukoc Biol. 2022 06; 111(6):1133-1145. PMID: 35355310; PMCID: PMC9133213.
    Citations:    Fields:    Translation:AnimalsCells
  7. Viens AL, Timmer KD, Alexander NJ, Barghout R, Milosevic J, Hopke A, Atallah NJ, Scherer AK, Sykes DB, Irimia D, Mansour MK. TLR Signaling Rescues Fungicidal Activity in Syk-Deficient Neutrophils. J Immunol. 2022 04 01; 208(7):1664-1674. PMID: 35277418; PMCID: PMC8976732.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Yan F, Li J, Milosevic J, Petroni R, Liu S, Shi Z, Yuan S, Reynaga JM, Qi Y, Rico J, Yu S, Liu Y, Rokudai S, Palmisiano N, Meyer SE, Sung PJ, Wan L, Lan F, Garcia BA, Stanger BZ, Sykes DB, Blanco MA. KAT6A and ENL Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs. Cancer Discov. 2022 03 01; 12(3):792-811. PMID: 34853079; PMCID: PMC8916037.
    Citations:    Fields:    Translation:HumansCells
  9. Murthy S, Baruah S, Bowen JL, Keck K, Wagner BA, Buettner GR, Sykes DB, Klesney-Tait J. TREM-1 is required for enhanced OpZ-induced superoxide generation following priming. J Leukoc Biol. 2022 Sep; 112(3):457-473. PMID: 35075692; PMCID: PMC9308838.
    Citations:    Fields:    
  10. Rosenberg JM, Peters JM, Hughes T, Lareau CA, Ludwig LS, Massoth LR, Austin-Tse C, Rehm HL, Bryson B, Chen YB, Regev A, Shalek AK, Fortune SM, Sykes DB. JAK inhibition in a patient with a STAT1 gain-of-function variant reveals STAT1 dysregulation as a common feature of aplastic anemia. Med (N Y). 2022 01 14; 3(1):42-57.e5. PMID: 35590143; PMCID: PMC9123284.
    Citations: 1     Translation:HumansCells
  11. Blanco MA, Sykes DB, Gu L, Wu M, Petroni R, Karnik R, Wawer M, Rico J, Li H, Jacobus WD, Jambhekar A, Cheloufi S, Meissner A, Hochedlinger K, Scadden DT, Shi Y. Chromatin-state barriers enforce an irreversible mammalian cell fate decision. Cell Rep. 2021 11 09; 37(6):109967. PMID: 34758323.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Kfoury Y, Baryawno N, Severe N, Mei S, Gustafsson K, Hirz T, Brouse T, Scadden EW, Igolkina AA, Kokkaliaris K, Choi BD, Barkas N, Randolph MA, Shin JH, Saylor PJ, Scadden DT, Sykes DB, Kharchenko PV. Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment. Cancer Cell. 2021 11 08; 39(11):1464-1478.e8. PMID: 34719426; PMCID: PMC8578470.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  13. Gadi SRV, Brunker PAR, Al-Samkari H, Sykes DB, Saff RR, Lo J, Bendapudi P, Leaf DE, Leaf RK. Severe autoimmune hemolytic anemia following receipt of SARS-CoV-2 mRNA vaccine. Transfusion. 2021 11; 61(11):3267-3271. PMID: 34549821.
    Citations: 5     Fields:    Translation:HumansCells
  14. Kfoury YS, Ji F, Mazzola M, Sykes DB, Scherer AK, Anselmo A, Akiyama Y, Mercier F, Severe N, Kokkaliaris KD, Zhao T, Brouse T, Saez B, Seidl J, Papazian A, Ivanov P, Mansour MK, Sadreyev RI, Scadden DT. tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche. Cell Stem Cell. 2021 12 02; 28(12):2090-2103.e9. PMID: 34551362.
    Citations: 2     Fields:    Translation:Cells
  15. Koh SB, Dontchos BN, Bossuyt V, Edmonds C, Cristea S, Melkonjan N, Mortensen L, Ma A, Beyerlin K, Denault E, Niehoff E, Hirz T, Sykes DB, Michor F, Specht M, Lehman C, Ellisen LW, Spring LM. Systematic tissue collection during clinical breast biopsy is feasible, safe and enables high-content translational analyses. NPJ Precis Oncol. 2021 Sep 21; 5(1):85. PMID: 34548623.
    Citations:    
  16. Scherer AK, Hopke A, Sykes DB, Irimia D, Mansour MK. Host defense against fungal pathogens: Adaptable neutrophil responses and the promise of therapeutic opportunities? PLoS Pathog. 2021 07; 17(7):e1009691. PMID: 34324592; PMCID: PMC8321001.
    Citations:    Fields:    Translation:HumansAnimalsCells
  17. Nguyen GT, Xu S, Adams W, Leong JM, Bunnell SC, Mansour MK, Sykes DB, Mecsas J. Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation. iScience. 2021 Aug 20; 24(8):102871. PMID: 34386732; PMCID: PMC8346660.
    Citations:    
  18. Calagua C, Ficial M, Jansen CS, Hirz T, Del Balzo L, Wilkinson S, Lake R, Ku AT, Voznesensky O, Sykes DB, Saylor PJ, Ye H, Signoretti S, Kissick H, Sowalsky AG, Balk SP, Einstein DJ. A Subset of Localized Prostate Cancer Displays an Immunogenic Phenotype Associated with Losses of Key Tumor Suppressor Genes. Clin Cancer Res. 2021 09 01; 27(17):4836-4847. PMID: 34168052; PMCID: PMC8416924.
    Citations: 2     Fields:    Translation:HumansCells
  19. Sporn ZA, Fenves AZ, Sykes DB, Al-Samkari H. Severe babesiosis with associated splenic infarcts and asplenia. Proc (Bayl Univ Med Cent). 2021 Sep; 34(5):597-599. PMID: 34456483.
    Citations:    
  20. Zee BM, Poels KE, Yao CH, Kawabata KC, Wu G, Duy C, Jacobus WD, Senior E, Endress JE, Jambhekar A, Lovitch SB, Ma J, Dhall A, Harris IS, Blanco MA, Sykes DB, Licht JD, Weinstock DM, Melnick A, Haigis MC, Michor F, Shi Y. Combined epigenetic and metabolic treatments overcome differentiation blockade in acute myeloid leukemia. iScience. 2021 Jun 25; 24(6):102651. PMID: 34151238.
    Citations:    
  21. Goreshnik A, Serling-Boyd N, Theodore M, Champion S, Stemmer-Rachamimov A, Sykes DB. A case of antisynthetase syndrome with thrombotic thrombocytopenic purpura. Rheumatology (Oxford). 2021 04 06; 60(4):e143-e145. PMID: 33221867; PMCID: PMC8023985.
    Citations:    Fields:    Translation:Humans
  22. Yusuf RZ, Saez B, Sharda A, van Gastel N, Yu VWC, Baryawno N, Scadden EW, Acharya S, Chattophadhyay S, Huang C, Viswanathan V, S'aulis D, Cobert J, Sykes DB, Keibler MA, Das S, Hutchinson JN, Churchill M, Mukherjee S, Lee D, Mercier F, Doench J, Bullinger L, Logan DJ, Schreiber S, Stephanopoulos G, Rizzo WB, Scadden DT. Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood. 2020 09 10; 136(11):1303-1316. PMID: 32458004; PMCID: PMC7483435.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  23. Reynolds KL, Klempner SJ, Parikh A, Hochberg EP, Michaelson MD, Mooradian MJ, Lee RJ, Soumerai TE, Hobbs G, Piotrowska Z, Sykes DB, Farago AF, Bardia A, Rosovsky RP, Ryan DP. The Art of Oncology: COVID-19 Era. Oncologist. 2020 11; 25(11):997-1000g. PMID: 32697887.
    Citations: 4     Fields:    Translation:HumansCells
  24. van Gastel N, Spinelli JB, Sharda A, Schajnovitz A, Baryawno N, Rhee C, Oki T, Grace E, Soled HJ, Milosevic J, Sykes DB, Hsu PP, Vander Heiden MG, Vidoudez C, Trauger SA, Haigis MC, Scadden DT. Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance. Cell Metab. 2020 09 01; 32(3):391-403.e6. PMID: 32763164.
    Citations: 28     Fields:    Translation:Animals
  25. Negoro PE, Xu S, Dagher Z, Hopke A, Reedy JL, Feldman MB, Khan NS, Viens AL, Alexander NJ, Atallah NJ, Scherer AK, Dutko RA, Jeffery J, Kernien JF, Fites JS, Nett JE, Klein BS, Vyas JM, Irimia D, Sykes DB, Mansour MK. Spleen Tyrosine Kinase Is a Critical Regulator of Neutrophil Responses to Candida Species. mBio. 2020 05 12; 11(3). PMID: 32398316; PMCID: PMC7218286.
    Citations: 12     Fields:    Translation:AnimalsCells
  26. Nguyen GT, Shaban L, Mack M, Swanson KD, Bunnell SC, Sykes DB, Mecsas J. SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst. Elife. 2020 04 30; 9. PMID: 32352382.
    Citations: 5     Fields:    Translation:AnimalsCells
  27. Sykes DB, O'Connell C, Schroyens W. The TEMPI syndrome. Blood. 2020 04 09; 135(15):1199-1203. PMID: 32108223.
    Citations: 11     Fields:    Translation:Humans
  28. Sykes DB, Zhang EW, Karp Leaf RS, Nardi V, Turbett SE. Case 10-2020: An 83-Year-Old Man with Pancytopenia and Acute Renal Failure. N Engl J Med. 2020 03 26; 382(13):1258-1266. PMID: 32212524.
    Citations: 1     Fields:    Translation:HumansCells
  29. Cabal-Hierro L, van Galen P, Prado MA, Higby KJ, Togami K, Mowery CT, Paulo JA, Xie Y, Cejas P, Furusawa T, Bustin M, Long HW, Sykes DB, Gygi SP, Finley D, Bernstein BE, Lane AA. Chromatin accessibility promotes hematopoietic and leukemia stem cell activity. Nat Commun. 2020 03 16; 11(1):1406. PMID: 32179749.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  30. Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest. 2020 03 02; 130(3):1513-1526. PMID: 32065590; PMCID: PMC7269595.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  31. Jan M, Grinshpun DE, Villalba JA, Dal Cin P, Sykes DB, Iafrate AJ, Ebert BL, Hobbs GS, Nardi V. A cryptic imatinib-sensitive G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia. Blood Adv. 2020 02 11; 4(3):445-448. PMID: 31999327; PMCID: PMC7013269.
    Citations: 2     Fields:    Translation:Humans
  32. Lee S, Micalizzi D, Truesdell SS, Bukhari SIA, Boukhali M, Lombardi-Story J, Kato Y, Choo MK, Dey-Guha I, Ji F, Nicholson BT, Myers DT, Lee D, Mazzola MA, Raheja R, Langenbucher A, Haradhvala NJ, Lawrence MS, Gandhi R, Tiedje C, Diaz-Muñoz MD, Sweetser DA, Sadreyev R, Sykes D, Haas W, Haber DA, Maheswaran S, Vasudevan S. A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. Genome Biol. 2020 02 10; 21(1):33. PMID: 32039742; PMCID: PMC7011231.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  33. Al-Samkari H, Rosovsky RP, Karp Leaf RS, Smith DB, Goodarzi K, Fogerty AE, Sykes DB, Kuter DJ. A modern reassessment of glycoprotein-specific direct platelet autoantibody testing in immune thrombocytopenia. Blood Adv. 2020 01 14; 4(1):9-18. PMID: 31891657.
    Citations: 15     Fields:    Translation:Humans
  34. Sykes DB. Insights From a Patient With Lung Cancer-Party Therapy Is Way Better Than Chemotherapy. JAMA Oncol. 2019 12 01; 5(12):1685-1686. PMID: 31513260.
    Citations:    Fields:    Translation:Humans
  35. Mann M, Kreuzbauer T, Sykes DB. A man with polycythemia vera, myelodysplastic syndrome and acquired microcytosis. BMJ Case Rep. 2019 Aug 13; 12(8). PMID: 31413051; PMCID: PMC6700592.
    Citations:    Fields:    Translation:Humans
  36. Ameri AH, Curtis BR, Sykes DB. Immune neutropenia mediated by micafungin. Am J Hematol. 2019 07; 94(7):830-832. PMID: 30945326.
    Citations:    Fields:    Translation:Humans
  37. Christian S, Merz C, Evans L, Gradl S, Seidel H, Friberg A, Eheim A, Lejeune P, Brzezinka K, Zimmermann K, Ferrara S, Meyer H, Lesche R, Stoeckigt D, Bauser M, Haegebarth A, Sykes DB, Scadden DT, Losman JA, Janzer A. The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies. Leukemia. 2019 10; 33(10):2403-2415. PMID: 30940908.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  38. Kugadas A, Geddes-McAlister J, Guy E, DiGiandomenico A, Sykes DB, Mansour MK, Mirchev R, Gadjeva M. Frontline Science: Employing enzymatic treatment options for management of ocular biofilm-based infections. J Leukoc Biol. 2019 06; 105(6):1099-1110. PMID: 30690787.
    Citations: 10     Fields:    Translation:AnimalsCells
  39. Sykes DB. The emergence of dihydroorotate dehydrogenase (DHODH) as a therapeutic target in acute myeloid leukemia. Expert Opin Ther Targets. 2018 11; 22(11):893-898. PMID: 30318938; PMCID: PMC6457988.
    Citations: 32     Fields:    Translation:HumansAnimals
  40. Garza-Mayers AC, Shah R, Sykes DB, Nigwekar SU, Kroshinsky D. The Successful Use of Apixaban in Dialysis Patients with Calciphylaxis Who Require Anticoagulation: A Retrospective Analysis. Am J Nephrol. 2018; 48(3):168-171. PMID: 30176675.
    Citations: 9     Fields:    Translation:Humans
  41. Lin B, Srikanth P, Castle AC, Nigwekar S, Malhotra R, Galloway JL, Sykes DB, Rajagopal J. Modulating Cell Fate as a Therapeutic Strategy. Cell Stem Cell. 2018 09 06; 23(3):329-341. PMID: 29910150; PMCID: PMC6128730.
    Citations: 14     Fields:    Translation:HumansAnimals
  42. Sykes DB, Schroyens W. Complete Responses in the TEMPI Syndrome after Treatment with Daratumumab. N Engl J Med. 2018 06 07; 378(23):2240-2242. PMID: 29874534.
    Citations: 6     Fields:    Translation:Humans
  43. Fites JS, Gui M, Kernien JF, Negoro P, Dagher Z, Sykes DB, Nett JE, Mansour MK, Klein BS. An unappreciated role for neutrophil-DC hybrids in immunity to invasive fungal infections. PLoS Pathog. 2018 05; 14(5):e1007073. PMID: 29782541; PMCID: PMC5983859.
    Citations: 29     Fields:    Translation:AnimalsCells
  44. Dagher Z, Xu S, Negoro PE, Khan NS, Feldman MB, Reedy JL, Tam JM, Sykes DB, Mansour MK. Fluorescent Tracking of Yeast Division Clarifies the Essential Role of Spleen Tyrosine Kinase in the Intracellular Control of Candida glabrata in Macrophages. Front Immunol. 2018; 9:1058. PMID: 29868018; PMCID: PMC5964189.
    Citations: 4     Fields:    Translation:AnimalsCells
  45. Xu S, Feliu M, Lord AK, Lukason DP, Negoro PE, Khan NS, Dagher Z, Feldman MB, Reedy JL, Steiger SN, Tam JM, Soukas AA, Sykes DB, Mansour MK. Biguanides enhance antifungal activity against Candida glabrata. Virulence. 2018; 9(1):1150-1162. PMID: 29962263; PMCID: PMC6086317.
    Citations: 7     Fields:    Translation:HumansAnimals
  46. Sykes DB, Rosovsky RP, Singhal AB, Gonzalez RG, Moy AP. Case 40-2017. A 32-Year-Old Woman with Headache, Abdominal Pain, Anemia, and Thrombocytopenia. N Engl J Med. 2017 12 28; 377(26):2581-2590. PMID: 29281575.
    Citations:    Fields:    Translation:Humans
  47. Sun L, Sykes DB. Acquired haemophilia A with a recalcitrant high-titre factor VIII inhibitor in the setting of interstitial lung disease. BMJ Case Rep. 2017 Jul 28; 2017. PMID: 28756381; PMCID: PMC5623308.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  48. Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26; 2(11). PMID: 28763796; PMCID: PMC6953719.
    Citations: 10     Fields:    
  49. Kalaitzidis D, Lee D, Efeyan A, Kfoury Y, Nayyar N, Sykes DB, Mercier FE, Papazian A, Baryawno N, Victora GD, Neuberg D, Sabatini DM, Scadden DT. Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells. J Clin Invest. 2017 Apr 03; 127(4):1405-1413. PMID: 28319048; PMCID: PMC5373863.
    Citations: 12     Fields:    Translation:AnimalsCells
  50. Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J. Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease. Nat Med. 2017 01; 23(1):100-106. PMID: 27941791; PMCID: PMC5405698.
    Citations: 64     Fields:    Translation:AnimalsCells
  51. Lewis TA, Sykes DB, Law JM, Muñoz B, Rustiguel JK, Nonato MC, Scadden DT, Schreiber SL. Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia. ACS Med Chem Lett. 2016 Dec 08; 7(12):1112-1117. PMID: 27994748; PMCID: PMC5150668.
    Citations: 17     
  52. Sykes DB, Kfoury YS, Mercier FE, Wawer MJ, Law JM, Haynes MK, Lewis TA, Schajnovitz A, Jain E, Lee D, Meyer H, Pierce KA, Tolliday NJ, Waller A, Ferrara SJ, Eheim AL, Stoeckigt D, Maxcy KL, Cobert JM, Bachand J, Szekely BA, Mukherjee S, Sklar LA, Kotz JD, Clish CB, Sadreyev RI, Clemons PA, Janzer A, Schreiber SL, Scadden DT. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia. Cell. 2016 Sep 22; 167(1):171-186.e15. PMID: 27641501; PMCID: PMC7360335.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  53. Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nat Biotechnol. 2016 07; 34(7):738-45. PMID: 27272386; PMCID: PMC5179034.
    Citations: 86     Fields:    Translation:AnimalsCells
  54. Mercier FE, Sykes DB, Scadden DT. Single Targeted Exon Mutation Creates a True Congenic Mouse for Competitive Hematopoietic Stem Cell Transplantation: The C57BL/6-CD45.1(STEM) Mouse. Stem Cell Reports. 2016 06 14; 6(6):985-992. PMID: 27185283.
    Citations: 23     Fields:    Translation:AnimalsCells
  55. Lee D, Wang YH, Kalaitzidis D, Ramachandran J, Eda H, Sykes DB, Raje N, Scadden DT. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016 Apr 01; 126(4):1300-10. PMID: 26927669; PMCID: PMC4811118.
    Citations: 7     Fields:    Translation:HumansAnimals
  56. Chen E, Ahn JS, Sykes DB, Breyfogle LJ, Godfrey AL, Nangalia J, Ko A, DeAngelo DJ, Green AR, Mullally A. RECQL5 Suppresses Oncogenic JAK2-Induced Replication Stress and Genomic Instability. Cell Rep. 2015 Dec 22; 13(11):2345-2352. PMID: 26686625; PMCID: PMC4691544.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  57. Kenderian SS, Rosado FG, Sykes DB, Hoyer JD, Lacy MQ. Long-term complete clinical and hematological responses of the TEMPI syndrome after autologous stem cell transplantation. Leukemia. 2015 Dec; 29(12):2414-6. PMID: 26500143.
    Citations: 6     Fields:    Translation:Humans
  58. Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015 Jul 31; 349(6247):1261669. PMID: 26228159; PMCID: PMC5215039.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  59. Lang D, Mead JS, Sykes DB. Hormones and the bone marrow: panhypopituitarism and pancytopenia in a man with a pituitary adenoma. J Gen Intern Med. 2015 May; 30(5):692-6. PMID: 25583570.
    Citations: 1     Fields:    Translation:Humans
  60. Belizaire R, Sykes DB, Chen YB, Spitzer TR, Makar RS. Difficulties in hematopoietic progenitor cell collection from a patient with TEMPI syndrome and severe iatrogenic iron deficiency. Transfusion. 2015 Sep; 55(9):2142-8. PMID: 25911963.
    Citations: 3     Fields:    Translation:HumansCells
  61. Sykes DB, Nichols DN. There Is No Denying It, Our Medical Language Needs an Update. J Grad Med Educ. 2015 Mar; 7(1):137-8. PMID: 26217448.
    Citations: 3     Fields:    Translation:Humans
  62. Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, Hideshima T, Dancík V, Majireck MM, Hussain MM, Singh S, Quiroz R, Iaconelli J, Karmacharya R, Tolliday NJ, Clemons PA, Moore MAS, Stern AM, Shamji AF, Ebert BL, Golub TR, Raje NS, Scadden DT, Schreiber SL. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Rep. 2015 Feb 10; 10(5):755-770. PMID: 25660025.
    Citations: 13     Fields:    
  63. Gupta S, Fenves A, Nance ST, Sykes DB, Dzik WS. Hyperhemolysis syndrome in a patient without a hemoglobinopathy, unresponsive to treatment with eculizumab. Transfusion. 2015 Mar; 55(3):623-8. PMID: 25257194.
    Citations: 8     Fields:    Translation:Humans
  64. Rosado FG, Oliveira JL, Sohani AR, Schroyens W, Sykes DB, Kenderian SS, Lacy MQ, Kyle RA, Hoyer JD. Bone marrow findings of the newly described TEMPI syndrome: when erythrocytosis and plasma cell dyscrasia coexist. Mod Pathol. 2015 Mar; 28(3):367-72. PMID: 25216227.
    Citations: 6     Fields:    Translation:Humans
  65. Khan J, Sykes DB. Case report: a 37-year-old male with telangiectasias, polycythemia vera, perinephric fluid collections, and intrapulmonary shunting. BMC Hematol. 2014; 14(1):11. PMID: 25143825.
    Citations:    
  66. Wu L, Walas S, Leung W, Sykes DB, Wu J, Lo EH, Lok J. Neuregulin1-ß decreases IL-1ß-induced neutrophil adhesion to human brain microvascular endothelial cells. Transl Stroke Res. 2015 Apr; 6(2):116-24. PMID: 24863743.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  67. Singh H, Lane AA, Correll M, Przychodzen B, Sykes DB, Stone RM, Ballen KK, Amrein PC, Maciejewski J, Attar EC. Putative RNA-splicing gene LUC7L2 on 7q34 represents a candidate gene in pathogenesis of myeloid malignancies. Blood Cancer J. 2013 May 24; 3:e117. PMID: 23708642.
    Citations: 12     Fields:    
  68. Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, Vyas JM. Dectin-1 activation controls maturation of ß-1,3-glucan-containing phagosomes. J Biol Chem. 2013 May 31; 288(22):16043-54. PMID: 23609446.
    Citations: 37     Fields:    Translation:AnimalsCells
  69. Simic P, Zainabadi K, Bell E, Sykes DB, Saez B, Lotinun S, Baron R, Scadden D, Schipani E, Guarente L. SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating ß-catenin. EMBO Mol Med. 2013 Mar; 5(3):430-40. PMID: 23364955.
    Citations: 111     Fields:    Translation:AnimalsCells
  70. Schroyens W, O'Connell C, Sykes DB. Complete and partial responses of the TEMPI syndrome to bortezomib. N Engl J Med. 2012 Aug 23; 367(8):778-80. PMID: 22913703.
    Citations: 6     Fields:    Translation:Humans
  71. Fiez-Vandal C, Leder L, Freuler F, Sykes D, Charlton SJ, Siehler S, Schopfer U, Duckely M. HDL-like discs for assaying membrane proteins in drug discovery. Biophys Chem. 2012 May; 165-166:56-61. PMID: 22542136.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  72. Park D, Sykes DB, Scadden DT. The hematopoietic stem cell niche. Front Biosci (Landmark Ed). 2012 01 01; 17(1):30-9. PMID: 22201730; PMCID: PMC4020275.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  73. Sykes DB, Schroyens W, O'Connell C. The TEMPI syndrome--a novel multisystem disease. N Engl J Med. 2011 Aug 04; 365(5):475-7. PMID: 21812700.
    Citations: 17     Fields:    Translation:Humans
  74. Scheele JS, Kolanczyk M, Gantert M, Zemojtel T, Dorn A, Sykes DB, Sykes DP, Möbest DC, Kamps MP, Räpple D, Duchniewicz M. The Spt-Ada-Gcn5-acetyltransferase complex interaction motif of E2a is essential for a subset of transcriptional and oncogenic properties of E2a-Pbx1. Leuk Lymphoma. 2009 May; 50(5):816-28. PMID: 19399691.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  75. Odegaard JI, Vats D, Zhang L, Ricardo-Gonzalez R, Smith KL, Sykes DB, Kamps MP, Chawla A. Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages. J Leukoc Biol. 2007 Mar; 81(3):711-9. PMID: 17158607; PMCID: PMC1904487.
    Citations: 14     Fields:    Translation:HumansCells
  76. Wang GG, Calvo KR, Pasillas MP, Sykes DB, Häcker H, Kamps MP. Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat Methods. 2006 Apr; 3(4):287-93. PMID: 16554834.
    Citations: 171     Fields:    Translation:AnimalsCells
  77. Sykes DB, Kamps MP. E2a/Pbx1 induces the rapid proliferation of stem cell factor-dependent murine pro-T cells that cause acute T-lymphoid or myeloid leukemias in mice. Mol Cell Biol. 2004 Feb; 24(3):1256-69. PMID: 14729970.
    Citations: 12     Fields:    Translation:AnimalsCells
  78. Sykes DB, Scheele J, Pasillas M, Kamps MP. Transcriptional profiling during the early differentiation of granulocyte and monocyte progenitors controlled by conditional versions of the E2a-Pbx1 oncoprotein. Leuk Lymphoma. 2003 Jul; 44(7):1187-99. PMID: 12916872.
    Citations: 5     Fields:    Translation:HumansCells
  79. Sykes DB, Kamps MP. Estrogen-regulated conditional oncoproteins: tools to address open questions in normal myeloid cell function, normal myeloid differentiation, and the genetic basis of differentiation arrest in myeloid leukemia. Leuk Lymphoma. 2003 Jul; 44(7):1131-9. PMID: 12916864.
    Citations:    Fields:    Translation:HumansAnimalsCells
  80. Welch JS, Escoubet-Lozach L, Sykes DB, Liddiard K, Greaves DR, Glass CK. TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism. J Biol Chem. 2002 Nov 08; 277(45):42821-9. PMID: 12215441.
    Citations: 97     Fields:    Translation:AnimalsCells
  81. Calvo KR, Sykes DB, Pasillas MP, Kamps MP. Nup98-HoxA9 immortalizes myeloid progenitors, enforces expression of Hoxa9, Hoxa7 and Meis1, and alters cytokine-specific responses in a manner similar to that induced by retroviral co-expression of Hoxa9 and Meis1. Oncogene. 2002 Jun 20; 21(27):4247-56. PMID: 12082612.
    Citations: 48     Fields:    Translation:AnimalsCells
  82. Klappacher GW, Lunyak VV, Sykes DB, Sawka-Verhelle D, Sage J, Brard G, Ngo SD, Gangadharan D, Jacks T, Kamps MP, Rose DW, Rosenfeld MG, Glass CK. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell. 2002 Apr 19; 109(2):169-80. PMID: 12007404.
    Citations: 45     Fields:    Translation:AnimalsCells
  83. Calvo KR, Knoepfler PS, Sykes DB, Pasillas MP, Kamps MP. Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13120-5. PMID: 11687616; PMCID: PMC60834.
    Citations: 41     Fields:    Translation:AnimalsCells
  84. Sykes DB, Kamps MP. Estrogen-dependent E2a/Pbx1 myeloid cell lines exhibit conditional differentiation that can be arrested by other leukemic oncoproteins. Blood. 2001 Oct 15; 98(8):2308-18. PMID: 11588024.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  85. Knoepfler PS, Sykes DB, Pasillas M, Kamps MP. HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. Oncogene. 2001 Sep 06; 20(39):5440-8. PMID: 11571641.
    Citations: 17     Fields:    Translation:AnimalsCells
  86. Slupsky CM, Sykes DB, Gay GL, Sykes BD. The HoxB1 hexapeptide is a prefolded domain: implications for the Pbx1/Hox interaction. Protein Sci. 2001 Jun; 10(6):1244-53. PMID: 11369863; PMCID: PMC2374006.
    Citations: 9     Fields:    Translation:HumansCells
  87. Calvo KR, Sykes DB, Pasillas M, Kamps MP. Hoxa9 immortalizes a granulocyte-macrophage colony-stimulating factor-dependent promyelocyte capable of biphenotypic differentiation to neutrophils or macrophages, independent of enforced meis expression. Mol Cell Biol. 2000 May; 20(9):3274-85. PMID: 10757811.
    Citations: 57     Fields:    Translation:AnimalsCells
  88. Ambrus JL, Ambrus CM, Dembinsky W, Sykes D, Kulaylat MN, Patel R, Akhter S, Islam A. Thromboembolic disease susceptibility related to red cell membrane fluidity in patients with polycythemia vera and effect of phlebotomies. J Med. 1999; 30(5-6):299-304. PMID: 10851563.
    Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
  89. Mehta N, Hordines J, Sykes D, Doerr RJ, Cohen SA. Low density lipoproteins and Lovastatin modulate the organ-specific transendothelial migration of primary and metastatic human colon adenocarcinoma cell lines in vitro. Clin Exp Metastasis. 1998 Oct; 16(7):587-94. PMID: 9932605.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  90. Parney IF, Petruk KC, Zhang C, Farr-Jones M, Sykes DB, Chang LJ. Granulocyte-macrophage colony-stimulating factor and B7-2 combination immunogene therapy in an allogeneic Hu-PBL-SCID/beige mouse-human glioblastoma multiforme model. Hum Gene Ther. 1997 Jun 10; 8(9):1073-85. PMID: 9189765.
    Citations: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  91. Sykes D, Dewar R, Mohanaruban K, Donovan K, Nicklason F, Thomas DM, Fisher D. Measuring blood pressure in the elderly: does atrial fibrillation increase observer variability? BMJ. 1990 Jan 20; 300(6718):162-3. PMID: 2105795; PMCID: PMC1662156.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  92. Wilson R, Pitt T, Taylor G, Watson D, MacDermot J, Sykes D, Roberts D, Cole P. Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit the beating of human respiratory cilia in vitro. J Clin Invest. 1987 Jan; 79(1):221-9. PMID: 3098783; PMCID: PMC424027.
    Citations: 74     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.