Harvard Catalyst Profiles

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Ottavio Valerio Vitolo, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fava M, Stahl S, Pani L, De Martin S, Pappagallo M, Guidetti C, Alimonti A, Bettini E, Mangano RM, Wessel T, de Somer M, Caron J, Vitolo OV, DiGuglielmo GR, Gilbert A, Mehta H, Kearney M, Mattarei A, Gentilucci M, Folli F, Traversa S, Inturrisi CE, Manfredi PL. REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial. Am J Psychiatry. 2022 02; 179(2):122-131. PMID: 34933568.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  2. Razafsha M, Buch KA, Vitolo OV, Chemali ZN. When real life conditions do not follow textbook diagnosis: A diagnostic challenge from a neuropsychiatric clinic. Int J Psychiatry Med. 2021 11; 56(6):459-469. PMID: 33297806.
    Citations:    Fields:    Translation:Humans
  3. Fogaça MV, Fukumoto K, Franklin T, Liu RJ, Duman CH, Vitolo OV, Duman RS. N-Methyl-D-aspartate receptor antagonist d-methadone produces rapid, mTORC1-dependent antidepressant effects. Neuropsychopharmacology. 2019 12; 44(13):2230-2238. PMID: 31454827; PMCID: PMC6898593.
    Citations: 16     Fields:    Translation:AnimalsCells
  4. Hanania T, Manfredi P, Inturrisi C, Vitolo OV. The N-methyl-D-aspartate receptor antagonist d-methadone acutely improves depressive-like behavior in the forced swim test performance of rats. Exp Clin Psychopharmacol. 2020 Apr; 28(2):196-201. PMID: 31368772.
    Citations: 6     Fields:    Translation:Animals
  5. Bernstein G, Davis K, Mills C, Wang L, McDonnell M, Oldenhof J, Inturrisi C, Manfredi PL, Vitolo OV. Characterization of the Safety and Pharmacokinetic Profile of D-Methadone, a Novel N-Methyl-D-Aspartate Receptor Antagonist in Healthy, Opioid-Naive Subjects: Results of Two Phase 1 Studies. J Clin Psychopharmacol. 2019 May/Jun; 39(3):226-237. PMID: 30939592.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  6. Arneric SP, Cedarbaum JM, Khozin S, Papapetropoulos S, Hill DL, Ropacki M, Rhodes J, Dacks PA, Hudson LD, Gordon MF, Kern VD, Romero K, Vradenburg G, Au R, Karlin DR, Facheris MF, Fitzer-Attas CJ, Vitolo OV, Wang J, Miller BM, Kaye JA. Biometric monitoring devices for assessing end points in clinical trials: developing an ecosystem. Nat Rev Drug Discov. 2017 10; 16(10):736. PMID: 28935908.
    Citations: 14     Fields:    Translation:Humans
  7. Delnomdedieu M, Forsberg A, Ogden A, Fazio P, Yu CR, Stenkrona P, Duvvuri S, David W, Al-Tawil N, Vitolo OV, Amini N, Nag S, Halldin C, Varrone A. In vivo measurement of PDE10A enzyme occupancy by positron emission tomography (PET) following single oral dose administration of PF-02545920 in healthy male subjects. Neuropharmacology. 2017 05 01; 117:171-181. PMID: 28122201.
    Citations: 7     Fields:    Translation:Humans
  8. Hendrix JA, Bateman RJ, Brashear HR, Duggan C, Carrillo MC, Bain LJ, DeMattos R, Katz RG, Ostrowitzki S, Siemers E, Sperling R, Vitolo OV. Challenges, solutions, and recommendations for Alzheimer's disease combination therapy. Alzheimers Dement. 2016 05; 12(5):623-30. PMID: 27017906.
    Citations: 11     Fields:    Translation:Humans
  9. Mischoulon D, De Jong MF, Vitolo OV, Cusin C, Dording CM, Yeung AS, Durham K, Parkin SR, Fava M, Dougherty DD. Efficacy and safety of a form of cranial electrical stimulation (CES) as an add-on intervention for treatment-resistant major depressive disorder: A three week double blind pilot study. J Psychiatr Res. 2015 Nov; 70:98-105. PMID: 26424428.
    Citations: 3     Fields:    Translation:Humans
  10. Sarris J, Papakostas GI, Vitolo O, Fava M, Mischoulon D. S-adenosyl methionine (SAMe) versus escitalopram and placebo in major depression RCT: efficacy and effects of histamine and carnitine as moderators of response. J Affect Disord. 2014 Aug; 164:76-81. PMID: 24856557.
    Citations: 14     Fields:    Translation:Humans
  11. Nyer M, Farabaugh A, Fehling K, Soskin D, Holt D, Papakostas GI, Pedrelli P, Fava M, Pisoni A, Vitolo O, Mischoulon D. Relationship between sleep disturbance and depression, anxiety, and functioning in college students. Depress Anxiety. 2013 Sep; 30(9):873-80. PMID: 23681944.
    Citations: 34     Fields:    Translation:Humans
  12. Dording CM, LaRocca RA, Hails KA, Vitolo OV, Wisniewski SR, Balasubramani GK, Trivedi M, Fava M, Mischoulon D. The effect of sildenafil on quality of life. Ann Clin Psychiatry. 2013 Feb; 25(1):3-10. PMID: 23376864.
    Citations: 2     Fields:    Translation:Humans
  13. Papakostas GI, Vitolo OV, Ishak WW, Rapaport MH, Zajecka JM, Kinrys G, Mischoulon D, Lipkin SH, Hails KA, Abrams J, Ward SG, Meisner A, Schoenfeld DA, Shelton RC, Winokur A, Okasha MS, Bari MA, Fava M. A 12-week, randomized, double-blind, placebo-controlled, sequential parallel comparison trial of ziprasidone as monotherapy for major depressive disorder. J Clin Psychiatry. 2012 Dec; 73(12):1541-7. PMID: 23290327.
    Citations: 7     Fields:    Translation:Humans
  14. Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Med. 2010 Mar; 12(1):27-43. PMID: 20069392.
    Citations: 251     Fields:    Translation:HumansAnimals
  15. Vitolo O, Gong B, Cao Z, Ishii H, Jaracz S, Nakanishi K, Arancio O, Dzyuba SV, Lefort R, Shelanski M. Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J. Neurobiol Aging. 2009 Feb; 30(2):257-65. PMID: 17640772; PMCID: PMC2646106.
    Citations: 13     Fields:    Translation:AnimalsCells
  16. Shrestha BR, Vitolo OV, Joshi P, Lordkipanidze T, Shelanski M, Dunaevsky A. Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. Mol Cell Neurosci. 2006 Nov; 33(3):274-82. PMID: 16962789.
    Citations: 52     Fields:    Translation:AnimalsCells
  17. Gong B, Cao Z, Zheng P, Vitolo OV, Liu S, Staniszewski A, Moolman D, Zhang H, Shelanski M, Arancio O. Ubiquitin hydrolase Uch-L1 rescues beta-amyloid-induced decreases in synaptic function and contextual memory. Cell. 2006 Aug 25; 126(4):775-88. PMID: 16923396.
    Citations: 188     Fields:    Translation:HumansAnimalsCells
  18. Puzzo D, Vitolo O, Trinchese F, Jacob JP, Palmeri A, Arancio O. Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity. J Neurosci. 2005 Jul 20; 25(29):6887-97. PMID: 16033898; PMCID: PMC6725343.
    Citations: 94     Fields:    Translation:AnimalsCells
  19. Gong B, Vitolo OV, Trinchese F, Liu S, Shelanski M, Arancio O. Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest. 2004 Dec; 114(11):1624-34. PMID: 15578094; PMCID: PMC529285.
    Citations: 165     Fields:    Translation:HumansAnimalsCells
  20. Moolman DL, Vitolo OV, Vonsattel JP, Shelanski ML. Dendrite and dendritic spine alterations in Alzheimer models. J Neurocytol. 2004 May; 33(3):377-87. PMID: 15475691.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  21. Ryu EJ, Harding HP, Angelastro JM, Vitolo OV, Ron D, Greene LA. Endoplasmic reticulum stress and the unfolded protein response in cellular models of Parkinson's disease. J Neurosci. 2002 Dec 15; 22(24):10690-8. PMID: 12486162; PMCID: PMC6758450.
    Citations: 215     Fields:    Translation:AnimalsCells
  22. Vitolo OV, Sant'Angelo A, Costanzo V, Battaglia F, Arancio O, Shelanski M. Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):13217-21. PMID: 12244210; PMCID: PMC130613.
    Citations: 224     Fields:    Translation:AnimalsCells
  23. Angelastro JM, Klimaschewski L, Tang S, Vitolo OV, Weissman TA, Donlin LT, Shelanski ML, Greene LA. Identification of diverse nerve growth factor-regulated genes by serial analysis of gene expression (SAGE) profiling. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10424-9. PMID: 10984536; PMCID: PMC27040.
    Citations: 40     Fields:    Translation:AnimalsCells
  24. Angelastro JM, Klimaschewski LP, Vitolo OV. Improved NlaIII digestion of PAGE-purified 102 bp ditags by addition of a single purification step in both the SAGE and microSAGE protocols. Nucleic Acids Res. 2000 Jun 15; 28(12):E62. PMID: 10871385; PMCID: PMC102747.
    Citations: 8     Fields:    Translation:AnimalsCells
  25. Piccini A, Ciotti MT, Vitolo OV, Calissano P, Tabaton M, Galli C. Endogenous APP derivatives oppositely modulate apoptosis through an autocrine loop. Neuroreport. 2000 May 15; 11(7):1375-9. PMID: 10841341.
    Citations: 3     Fields:    Translation:AnimalsCells
  26. Vitolo OV, Ciotti MT, Galli C, Borsello T, Calissano P. Adenosine and ADP prevent apoptosis in cultured rat cerebellar granule cells. Brain Res. 1998 Nov 02; 809(2):297-301. PMID: 9853123.
    Citations: 10     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.