Harvard Catalyst Profiles

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M. Korkut Uygun, Ph.D.

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Biography
2008 - 2013
NIH Pathway to Independence Award

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rey-Bedon C, Banik P, Gokaltun A, Hofheinz O, Yarmush ML, Uygun MK, Usta OB. CYP450 drug inducibility in NAFLD via an in vitro hepatic model: Understanding drug-drug interactions in the fatty liver. Biomed Pharmacother. 2022 Feb; 146:112377. PMID: 35062050; PMCID: PMC8792443.
    Citations:    Fields:    Translation:HumansCells
  2. Uygun M, Jurado-Sánchez B, Uygun DA, Singh VV, Zhang L, Wang J. Ultrasound-propelled nanowire motors enhance asparaginase enzymatic activity against cancer cells. Nanoscale. 2017 Nov 30; 9(46):18423-18429. PMID: 29148558.
    Citations: 3     Fields:    Translation:AnimalsCells
  3. Singh VV, Kaufmann K, Esteban-Fernández de Ávila B, Uygun M, Wang J. Nanomotors responsive to nerve-agent vapor plumes. Chem Commun (Camb). 2016 Feb 25; 52(16):3360-3. PMID: 26824395.
    Citations: 8     Fields:    
  4. Uygun M, Singh VV, Kaufmann K, Uygun DA, de Oliveira SD, Wang J. Micromotor-Based Biomimetic Carbon Dioxide Sequestration: Towards Mobile Microscrubbers. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):12900-4. PMID: 26337033.
    Citations: 4     Fields:    Translation:Cells
  5. Kiristi M, Singh VV, Esteban-Fernández de Ávila B, Uygun M, Soto F, Aktas Uygun D, Wang J. Lysozyme-Based Antibacterial Nanomotors. ACS Nano. 2015 Sep 22; 9(9):9252-9. PMID: 26308491.
    Citations: 14     Fields:    Translation:HumansCells
  6. Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, Izamis ML, Toner M, Yarmush ML, Uygun K. Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med. 2014 Jul; 20(7):790-3. PMID: 24973919.
    Citations: 44     Fields:    Translation:Animals
  7. op den Dries S, Westerkamp AC, Karimian N, Gouw AS, Bruinsma BG, Markmann JF, Lisman T, Yeh H, Uygun K, Martins PN, Porte RJ. Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures. J Hepatol. 2014 Jun; 60(6):1172-9. PMID: 24560661.
    Citations: 45     Fields:    Translation:Humans
  8. Bruinsma BG, Berendsen TA, Izamis ML, Yarmush ML, Uygun K. Determination and extension of the limits to static cold storage using subnormothermic machine perfusion. Int J Artif Organs. 2013 Nov; 36(11):775-80. PMID: 24338652.
    Citations: 23     Fields:    Translation:Animals
  9. Liu Q, Izamis ML, Xu H, Berendsen T, Yarmush M, Uygun K. Strategies to rescue steatotic livers before transplantation in clinical and experimental studies. World J Gastroenterol. 2013 Aug 07; 19(29):4638-50. PMID: 23922462.
    Citations: 6     Fields:    Translation:HumansAnimals
  10. Izamis ML, Tolboom H, Uygun B, Berthiaume F, Yarmush ML, Uygun K. Resuscitation of ischemic donor livers with normothermic machine perfusion: a metabolic flux analysis of treatment in rats. PLoS One. 2013; 8(7):e69758. PMID: 23922793.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  11. Usta OB, Kim Y, Ozer S, Bruinsma BG, Lee J, Demir E, Berendsen TA, Puts CF, Izamis ML, Uygun K, Uygun BE, Yarmush ML. Supercooling as a viable non-freezing cell preservation method of rat hepatocytes. PLoS One. 2013; 8(7):e69334. PMID: 23874947.
    Citations: 16     Fields:    Translation:AnimalsCells
  12. Saeidi N, Nestoridi E, Kucharczyk J, Uygun MK, Yarmush ML, Stylopoulos N. Sleeve gastrectomy and Roux-en-Y gastric bypass exhibit differential effects on food preferences, nutrient absorption and energy expenditure in obese rats. Int J Obes (Lond). 2012 Nov; 36(11):1396-402. PMID: 23044855.
    Citations: 44     Fields:    Translation:Animals
  13. Uygun BE, Yarmush ML, Uygun K. Application of whole-organ tissue engineering in hepatology. Nat Rev Gastroenterol Hepatol. 2012 12; 9(12):738-44. PMID: 22890112.
    Citations: 24     Fields:    Translation:AnimalsCells
  14. Izamis ML, Uygun K, Sharma NS, Uygun B, Yarmush ML, Berthiaume F. Development of Metabolic Indicators of Burn Injury: Very Low Density Lipoprotein (VLDL) and Acetoacetate Are Highly Correlated to Severity of Burn Injury in Rats. Metabolites. 2012 Jul 16; 2(3):458-78. PMID: 24957642.
    Citations: 4     
  15. Perk S, Izamis ML, Tolboom H, Uygun B, Yarmush ML, Uygun K. A fitness index for transplantation of machine-perfused cadaveric rat livers. BMC Res Notes. 2012 Jun 25; 5:325. PMID: 22731806.
    Citations: 13     Fields:    Translation:HumansAnimals
  16. Berendsen TA, Bruinsma BG, Lee J, D'Andrea V, Liu Q, Izamis ML, Uygun K, Yarmush ML. A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation. Transplant Res. 2012 May 09; 1(1):6. PMID: 23369351.
    Citations: 38     
  17. Perk S, Izamis ML, Tolboom H, Uygun B, Berthiaume F, Yarmush ML, Uygun K. A metabolic index of ischemic injury for perfusion-recovery of cadaveric rat livers. PLoS One. 2011; 6(12):e28518. PMID: 22194843.
    Citations: 17     Fields:    Translation:HumansAnimals
  18. Lu Y, Zhang G, Shen C, Uygun K, Yarmush ML, Meng Q. A novel 3D liver organoid system for elucidation of hepatic glucose metabolism. Biotechnol Bioeng. 2012 Feb; 109(2):595-604. PMID: 22006574.
    Citations: 15     Fields:    Translation:AnimalsCells
  19. Badylak SF, Taylor D, Uygun K. Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds. Annu Rev Biomed Eng. 2011 Aug 15; 13:27-53. PMID: 21417722.
    Citations: 324     Fields:    Translation:HumansAnimalsCells
  20. Tolboom H, Izamis ML, Sharma N, Milwid JM, Uygun B, Berthiaume F, Uygun K, Yarmush ML. Subnormothermic machine perfusion at both 20°C and 30°C recovers ischemic rat livers for successful transplantation. J Surg Res. 2012 Jun 01; 175(1):149-56. PMID: 21550058.
    Citations: 39     Fields:    Translation:Animals
  21. Uygun BE, Price G, Saedi N, Izamis ML, Berendsen T, Yarmush M, Uygun K. Decellularization and recellularization of whole livers. J Vis Exp. 2011 Feb 04; (48). PMID: 21339718.
    Citations: 14     Fields:    Translation:Animals
  22. Izamis ML, Sharma NS, Uygun B, Bieganski R, Saeidi N, Nahmias Y, Uygun K, Yarmush ML, Berthiaume F. In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnol Bioeng. 2011 Apr; 108(4):839-52. PMID: 21404258.
    Citations: 18     Fields:    Translation:AnimalsCells
  23. Izamis ML, Sharma NS, Uygun B, Bieganski R, Saeidi N, Nahmias Y, Uygun K, Yarmush ML, Berthiaume F. In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnol Bioeng. 2010 Nov 12. PMID: 21077107.
    Citations:    
  24. Uygun K, Uygun B, Matthew HW, Huang Y. Optimization-based metabolic control analysis. Biotechnol Prog. 2010 Nov-Dec; 26(6):1567-79. PMID: 20967921.
    Citations: 2     Fields:    
  25. Uygun BE, Soto-Gutierrez A, Yagi H, Izamis ML, Guzzardi MA, Shulman C, Milwid J, Kobayashi N, Tilles A, Berthiaume F, Hertl M, Nahmias Y, Yarmush ML, Uygun K. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med. 2010 Jul; 16(7):814-20. PMID: 20543851.
    Citations: 407     Fields:    Translation:HumansAnimalsCells
  26. Soto-Gutierrez A, Yagi H, Uygun BE, Navarro-Alvarez N, Uygun K, Kobayashi N, Yang YG, Yarmush ML. Cell delivery: from cell transplantation to organ engineering. Cell Transplant. 2010; 19(6):655-65. PMID: 20525441.
    Citations: 22     Fields:    Translation:Animals
  27. Izamis ML, Uygun K, Uygun B, Yarmush ML, Berthiaume F. Effects of burn injury on markers of hypermetabolism in rats. J Burn Care Res. 2009 Nov-Dec; 30(6):993-1001. PMID: 19898103.
    Citations: 7     Fields:    Translation:Animals
  28. Bilgen B, Uygun K, Bueno EM, Sucosky P, Barabino GA. Tissue growth modeling in a wavy-walled bioreactor. Tissue Eng Part A. 2009 Apr; 15(4):761-71. PMID: 18847355.
    Citations: 4     Fields:    Translation:AnimalsCells
  29. Roach KL, King KR, Uygun K, Hand SC, Kohane IS, Yarmush ML, Toner M. High-throughput single cell arrays as a novel tool in biopreservation. Cryobiology. 2009 Jun; 58(3):315-21. PMID: 19303403.
    Citations: 6     Fields:    Translation:Cells
  30. Tolboom H, Pouw RE, Izamis ML, Milwid JM, Sharma N, Soto-Gutierrez A, Nahmias Y, Uygun K, Berthiaume F, Yarmush ML. Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion. Transplantation. 2009 Jan 27; 87(2):170-7. PMID: 19155970.
    Citations: 31     Fields:    Translation:Animals
  31. Tolboom H, Milwid JM, Izamis ML, Uygun K, Berthiaume F, Yarmush ML. Sequential cold storage and normothermic perfusion of the ischemic rat liver. Transplant Proc. 2008 Jun; 40(5):1306-9. PMID: 18589093.
    Citations: 18     Fields:    Translation:HumansAnimals
  32. Tolboom H, Pouw R, Uygun K, Tanimura Y, Izamis ML, Berthiaume F, Yarmush ML. A model for normothermic preservation of the rat liver. Tissue Eng. 2007 Aug; 13(8):2143-51. PMID: 17596120.
    Citations: 24     Fields:    Translation:Animals
  33. Uygun K, Matthew HW, Huang Y. Investigation of metabolic objectives in cultured hepatocytes. Biotechnol Bioeng. 2007 Jun 15; 97(3):622-37. PMID: 17058287.
    Citations: 11     Fields:    Translation:Cells
  34. Uygun, K., H.W.T. Matthew, and Y. L. Huang. I&ECR. DFBA-LQR: An Optimal Control Approach to Flux Balance Analysis. 2006; 25(45):8554-8564.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.