Harvard Catalyst Profiles

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M. Korkut Uygun, Ph.D.

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Biography
2008 - 2013
NIH Pathway to Independence Award

Research
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, Izamis ML, Toner M, Yarmush ML, Uygun K. Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med. 2014 Jul; 20(7):790-3. PMID: 24973919; PMCID: PMC4141719.
    Citations: 16     Fields:    Translation:Animals
  2. op den Dries S, Westerkamp AC, Karimian N, Gouw AS, Bruinsma BG, Markmann JF, Lisman T, Yeh H, Uygun K, Martins PN, Porte RJ. Injury to peribiliary glands and vascular plexus before liver transplantation predicts formation of non-anastomotic biliary strictures. J Hepatol. 2014 Jun; 60(6):1172-9. PMID: 24560661.
    Citations: 15     Fields:    Translation:Humans
  3. Bruinsma BG, Berendsen TA, Izamis ML, Yarmush ML, Uygun K. Determination and extension of the limits to static cold storage using subnormothermic machine perfusion. Int J Artif Organs. 2013 Nov; 36(11):775-80. PMID: 24338652; PMCID: PMC4091033.
    Citations: 12     Fields:    Translation:Animals
  4. Liu Q, Izamis ML, Xu H, Berendsen T, Yarmush M, Uygun K. Strategies to rescue steatotic livers before transplantation in clinical and experimental studies. World J Gastroenterol. 2013 Aug 07; 19(29):4638-50. PMID: 23922462; PMCID: PMC3732837.
    Citations: 3     Fields:    Translation:HumansAnimals
  5. Izamis ML, Tolboom H, Uygun B, Berthiaume F, Yarmush ML, Uygun K. Resuscitation of ischemic donor livers with normothermic machine perfusion: a metabolic flux analysis of treatment in rats. PLoS One. 2013; 8(7):e69758. PMID: 23922793; PMCID: PMC3724866.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  6. Usta OB, Kim Y, Ozer S, Bruinsma BG, Lee J, Demir E, Berendsen TA, Puts CF, Izamis ML, Uygun K, Uygun BE, Yarmush ML. Supercooling as a viable non-freezing cell preservation method of rat hepatocytes. PLoS One. 2013; 8(7):e69334. PMID: 23874947; PMCID: PMC3713052.
    Citations: 9     Fields:    Translation:AnimalsCells
  7. Saeidi N, Nestoridi E, Kucharczyk J, Uygun MK, Yarmush ML, Stylopoulos N. Sleeve gastrectomy and Roux-en-Y gastric bypass exhibit differential effects on food preferences, nutrient absorption and energy expenditure in obese rats. Int J Obes (Lond). 2012 Nov; 36(11):1396-402. PMID: 23044855; PMCID: PMC3651693.
    Citations: 26     Fields:    Translation:Animals
  8. Uygun BE, Yarmush ML, Uygun K. Application of whole-organ tissue engineering in hepatology. Nat Rev Gastroenterol Hepatol. 2012 12; 9(12):738-44. PMID: 22890112; PMCID: PMC3732057.
    Citations: 13     Fields:    Translation:AnimalsCells
  9. Izamis ML, Uygun K, Sharma NS, Uygun B, Yarmush ML, Berthiaume F. Development of Metabolic Indicators of Burn Injury: Very Low Density Lipoprotein (VLDL) and Acetoacetate Are Highly Correlated to Severity of Burn Injury in Rats. Metabolites. 2012 Jul 16; 2(3):458-78. PMID: 24957642; PMCID: PMC3901222.
    Citations: 2     
  10. Perk S, Izamis ML, Tolboom H, Uygun B, Yarmush ML, Uygun K. A fitness index for transplantation of machine-perfused cadaveric rat livers. BMC Res Notes. 2012 Jun 25; 5:325. PMID: 22731806; PMCID: PMC3441584.
    Citations: 10     Fields:    Translation:HumansAnimals
  11. Berendsen TA, Bruinsma BG, Lee J, D'Andrea V, Liu Q, Izamis ML, Uygun K, Yarmush ML. A simplified subnormothermic machine perfusion system restores ischemically damaged liver grafts in a rat model of orthotopic liver transplantation. Transplant Res. 2012 May 09; 1(1):6. PMID: 23369351; PMCID: PMC3552573.
    Citations: 24     
  12. Perk S, Izamis ML, Tolboom H, Uygun B, Berthiaume F, Yarmush ML, Uygun K. A metabolic index of ischemic injury for perfusion-recovery of cadaveric rat livers. PLoS One. 2011; 6(12):e28518. PMID: 22194843; PMCID: PMC3237452.
    Citations: 12     Fields:    Translation:HumansAnimals
  13. Lu Y, Zhang G, Shen C, Uygun K, Yarmush ML, Meng Q. A novel 3D liver organoid system for elucidation of hepatic glucose metabolism. Biotechnol Bioeng. 2012 Feb; 109(2):595-604. PMID: 22006574; PMCID: PMC3907714.
    Citations: 10     Fields:    Translation:AnimalsCells
  14. Badylak SF, Taylor D, Uygun K. Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds. Annu Rev Biomed Eng. 2011 Aug 15; 13:27-53. PMID: 21417722.
    Citations: 192     Fields:    Translation:HumansAnimalsCells
  15. Tolboom H, Izamis ML, Sharma N, Milwid JM, Uygun B, Berthiaume F, Uygun K, Yarmush ML. Subnormothermic machine perfusion at both 20°C and 30°C recovers ischemic rat livers for successful transplantation. J Surg Res. 2012 Jun 01; 175(1):149-56. PMID: 21550058; PMCID: PMC3863393.
    Citations: 28     Fields:    Translation:Animals
  16. Uygun BE, Price G, Saedi N, Izamis ML, Berendsen T, Yarmush M, Uygun K. Decellularization and recellularization of whole livers. J Vis Exp. 2011 Feb 04; (48). PMID: 21339718; PMCID: PMC3197392.
    Citations: 8     Fields:    Translation:Animals
  17. Izamis ML, Sharma NS, Uygun B, Bieganski R, Saeidi N, Nahmias Y, Uygun K, Yarmush ML, Berthiaume F. In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnol Bioeng. 2011 Apr; 108(4):839-52. PMID: 21404258; PMCID: PMC3277812.
    Citations: 14     Fields:    Translation:AnimalsCells
  18. Izamis ML, Sharma NS, Uygun B, Bieganski R, Saeidi N, Nahmias Y, Uygun K, Yarmush ML, Berthiaume F. In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnol Bioeng. 2010 Nov 12. PMID: 21077107.
    Citations:    
  19. Uygun K, Uygun B, Matthew HW, Huang Y. Optimization-based metabolic control analysis. Biotechnol Prog. 2010 Nov-Dec; 26(6):1567-79. PMID: 20967921.
    Citations: 2     Fields:    
  20. Uygun BE, Soto-Gutierrez A, Yagi H, Izamis ML, Guzzardi MA, Shulman C, Milwid J, Kobayashi N, Tilles A, Berthiaume F, Hertl M, Nahmias Y, Yarmush ML, Uygun K. Organ reengineering through development of a transplantable recellularized liver graft using decellularized liver matrix. Nat Med. 2010 Jul; 16(7):814-20. PMID: 20543851; PMCID: PMC2930603.
    Citations: 273     Fields:    Translation:HumansAnimalsCells
  21. Soto-Gutierrez A, Yagi H, Uygun BE, Navarro-Alvarez N, Uygun K, Kobayashi N, Yang YG, Yarmush ML. Cell delivery: from cell transplantation to organ engineering. Cell Transplant. 2010; 19(6):655-65. PMID: 20525441; PMCID: PMC2957541.
    Citations: 20     Fields:    Translation:Animals
  22. Izamis ML, Uygun K, Uygun B, Yarmush ML, Berthiaume F. Effects of burn injury on markers of hypermetabolism in rats. J Burn Care Res. 2009 Nov-Dec; 30(6):993-1001. PMID: 19898103.
    Citations: 7     Fields:    Translation:Animals
  23. Bilgen B, Uygun K, Bueno EM, Sucosky P, Barabino GA. Tissue growth modeling in a wavy-walled bioreactor. Tissue Eng Part A. 2009 Apr; 15(4):761-71. PMID: 18847355.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Roach KL, King KR, Uygun K, Hand SC, Kohane IS, Yarmush ML, Toner M. High-throughput single cell arrays as a novel tool in biopreservation. Cryobiology. 2009 Jun; 58(3):315-21. PMID: 19303403; PMCID: PMC2717893.
    Citations: 4     Fields:    Translation:Cells
  25. Tolboom H, Pouw RE, Izamis ML, Milwid JM, Sharma N, Soto-Gutierrez A, Nahmias Y, Uygun K, Berthiaume F, Yarmush ML. Recovery of warm ischemic rat liver grafts by normothermic extracorporeal perfusion. Transplantation. 2009 Jan 27; 87(2):170-7. PMID: 19155970; PMCID: PMC2743395.
    Citations: 25     Fields:    Translation:Animals
  26. Tolboom H, Milwid JM, Izamis ML, Uygun K, Berthiaume F, Yarmush ML. Sequential cold storage and normothermic perfusion of the ischemic rat liver. Transplant Proc. 2008 Jun; 40(5):1306-9. PMID: 18589093; PMCID: PMC2583139.
    Citations: 15     Fields:    Translation:HumansAnimals
  27. Tolboom H, Pouw R, Uygun K, Tanimura Y, Izamis ML, Berthiaume F, Yarmush ML. A model for normothermic preservation of the rat liver. Tissue Eng. 2007 Aug; 13(8):2143-51. PMID: 17596120.
    Citations: 18     Fields:    Translation:Animals
  28. Uygun K, Matthew HW, Huang Y. Investigation of metabolic objectives in cultured hepatocytes. Biotechnol Bioeng. 2007 Jun 15; 97(3):622-37. PMID: 17058287.
    Citations: 9     Fields:    Translation:Cells
  29. Uygun, K., H.W.T. Matthew, and Y. L. Huang. I&ECR. DFBA-LQR: An Optimal Control Approach to Flux Balance Analysis. 2006; 25(45):8554-8564.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.