Harvard Catalyst Profiles

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William Chun Hahn, Ph.D., M.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
Determining the molecular mechanisms by which PRKACA confers resistance to anti-HER2 therapy in HER2-positive breast cancers
Summer, 06/26/13 - 09/04/13
The Role of Retinoblastoma Protein Regulators in Human Prostate Cell Replicative Senescence
Summer, 04/08/02 - 08/31/02

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01CA224146 (HAHN, WILLIAM C) Sep 30, 2017 - Aug 31, 2020
    NIH/NCI
    Systematic interrogation of the pancreatic cancer microenvironment in patient-derived specimens
    Role: Principal Investigator
  2. U01CA199253 (HAHN, WILLIAM C) Sep 25, 2015 - Aug 31, 2019
    NIH/NCI
    Systematic identification of oncogenic KRAS synthetic lethal interactions
    Role: Principal Investigator
  3. U01CA176058 (HAHN, WILLIAM C) May 1, 2013 - Jul 31, 2022
    NIH/NCI
    The Dana-Farber Cancer Institute Cancer Target Discovery and Development Center
    Role: Co-Principal Investigator
  4. R03MH097485 (HAHN, WILLIAM C) Sep 20, 2012 - Aug 31, 2014
    NIH/NIMH
    Discovering modulators of PAX8 for targeting ovarian cancer
    Role: Principal Investigator
  5. P01CA154303 (MEYERSON, MATTHEW L.) May 11, 2012 - Aug 31, 2022
    NIH/NCI
    Protein Kinase Therapeutic Targets for Non-Small Cell Lung Carcinoma
    Role: Co-Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Center for Cancer Genome Discovery (DFCI) - Core services (5) and Instruments (3)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, Zhang T, Gray NS, Clarke PA, Blagg J, Workman P, Sommer J, Hornicek F, Root DE, Hahn WC, Bradner JE, Wong KK, Clemons PA, Lin CY, Kotz JD, Schreiber SL. Small-molecule targeting of brachyury transcription factor addiction in chordoma. Nat Med. 2019 Feb; 25(2):292-300. PMID: 30664779.
    Citations:    Fields:    
  2. Gannon HS, Zou T, Kiessling MK, Gao GF, Cai D, Choi PS, Ivan AP, Buchumenski I, Berger AC, Goldstein JT, Cherniack AD, Vazquez F, Tsherniak A, Levanon EY, Hahn WC, Meyerson M. Identification of ADAR1 adenosine deaminase dependency in a subset of cancer cells. Nat Commun. 2018 12 21; 9(1):5450. PMID: 30575730.
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  3. Neal JT, Li X, Zhu J, Giangarra V, Grzeskowiak CL, Ju J, Liu IH, Chiou SH, Salahudeen AA, Smith AR, Deutsch BC, Liao L, Zemek AJ, Zhao F, Karlsson K, Schultz LM, Metzner TJ, Nadauld LD, Tseng YY, Alkhairy S, Oh C, Keskula P, Mendoza-Villanueva D, De La Vega FM, Kunz PL, Liao JC, Leppert JT, Sunwoo JB, Sabatti C, Boehm JS, Hahn WC, Zheng GXY, Davis MM, Kuo CJ. Organoid Modeling of the Tumor Immune Microenvironment. Cell. 2018 Dec 13; 175(7):1972-1988.e16. PMID: 30550791.
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  4. McFarland JM, Ho ZV, Kugener G, Dempster JM, Montgomery PG, Bryan JG, Krill-Burger JM, Green TM, Vazquez F, Boehm JS, Golub TR, Hahn WC, Root DE, Tsherniak A. Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration. Nat Commun. 2018 Nov 02; 9(1):4610. PMID: 30389920.
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  5. Choudhury AD, Werner L, Francini E, Wei XX, Ha G, Freeman SS, Rhoades J, Reed SC, Gydush G, Rotem D, Lo C, Taplin ME, Harshman LC, Zhang Z, O'Connor EP, Stover DG, Parsons HA, Getz G, Meyerson M, Love JC, Hahn WC, Adalsteinsson VA. Tumor fraction in cell-free DNA as a biomarker in prostate cancer. JCI Insight. 2018 Nov 02; 3(21). PMID: 30385733.
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  6. Giacomelli AO, Yang X, Lintner RE, McFarland JM, Duby M, Kim J, Howard TP, Takeda DY, Ly SH, Kim E, Gannon HS, Hurhula B, Sharpe T, Goodale A, Fritchman B, Steelman S, Vazquez F, Tsherniak A, Aguirre AJ, Doench JG, Piccioni F, Roberts CWM, Meyerson M, Getz G, Johannessen CM, Root DE, Hahn WC. Mutational processes shape the landscape of TP53 mutations in human cancer. Nat Genet. 2018 Oct; 50(10):1381-1387. PMID: 30224644.
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  7. Durbin AD, Zimmerman MW, Dharia NV, Abraham BJ, Iniguez AB, Weichert-Leahey N, He S, Krill-Burger JM, Root DE, Vazquez F, Tsherniak A, Hahn WC, Golub TR, Young RA, Look AT, Stegmaier K. Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry. Nat Genet. 2018 Sep; 50(9):1240-1246. PMID: 30127528.
    Citations: 1     Fields:    
  8. Lo JH, Hao L, Muzumdar MD, Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS, Hahn WC, Jacks T, Bhatia SN. iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer. Mol Cancer Ther. 2018 Nov; 17(11):2377-2388. PMID: 30097486.
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  9. Sandoval GJ, Pulice JL, Pakula H, Schenone M, Takeda DY, Pop M, Boulay G, Williamson KE, McBride MJ, Pan J, St Pierre R, Hartman E, Garraway LA, Carr SA, Rivera MN, Li Z, Ronco L, Hahn WC, Kadoch C. Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis. Mol Cell. 2018 Aug 16; 71(4):554-566.e7. PMID: 30078722.
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  10. Aguirre AJ, Hahn WC. Synthetic Lethal Vulnerabilities in KRAS-Mutant Cancers. Cold Spring Harb Perspect Med. 2018 Aug 01; 8(8). PMID: 29101114.
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