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Sasha Anna Singh, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Higashi H, Maejima T, Lee LH, Yamazaki Y, Hottiger MO, Singh SA, Aikawa M. A Study into the ADP-Ribosylome of IFN-?-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation. J Proteome Res. 2019 Mar 21. PMID: 30848916.
    Citations:    
  2. Nakano T, Katsuki S, Chen M, Decano JL, Halu A, Lee LH, Pestana DVS, Kum AST, Kuromoto RK, Golden WS, Boff MS, Guimaraes GC, Higashi H, Kauffman KJ, Maejima T, Suzuki T, Iwata H, Barabási AL, Aster JC, Anderson DG, Sharma A, Singh SA, Aikawa E, Aikawa M. Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling. Circulation. 2019 Jan 02; 139(1):78-96. PMID: 30586693.
    Citations:    Fields:    
  3. Creager MD, Hohl T, Hutcheson JD, Moss AJ, Schlotter F, Blaser MC, Park MA, Lee LH, Singh SA, Alcaide-Corral CJ, Tavares AAS, Newby DE, Kijewski MF, Aikawa M, Di Carli M, Dweck MR, Aikawa E. 18F-Fluoride Signal Amplification Identifies Microcalcifications Associated With Atherosclerotic Plaque Instability in Positron Emission Tomography/Computed Tomography Images. Circ Cardiovasc Imaging. 2019 Jan; 12(1):e007835. PMID: 30642216.
    Citations:    Fields:    
  4. Lee LH, Halu A, Morgan S, Iwata H, Aikawa M, Singh SA. XINA: A Workflow for the Integration of Multiplexed Proteomics Kinetics Data with Network Analysis. J Proteome Res. 2019 Feb 01; 18(2):775-781. PMID: 30370770.
    Citations:    Fields:    
  5. Halu A, Wang JG, Iwata H, Mojcher A, Abib AL, Singh SA, Aikawa M, Sharma A. Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation. Elife. 2018 10 10; 7. PMID: 30303482.
    Citations:    Fields:    Translation:HumansCells
  6. Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E. Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease. Circulation. 2018 Jul 24; 138(4):377-393. PMID: 29588317.
    Citations:    Fields:    
  7. Lei Y. WITHDRAWN: Catalytically inactive phosphatase MTMR12 is a novel regulator of osteoclast function through F-actin ring formation. Biochim Biophys Acta Mol Basis Dis. 2018 Jun 12. PMID: 29902551.
    Citations:    
  8. Singh SA, Aikawa M. Unbiased and targeted mass spectrometry for the HDL proteome. Curr Opin Lipidol. 2017 02; 28(1):68-77. PMID: 28002079.
    Citations:    Fields:    Translation:HumansAnimals
  9. Lee LH, Andraski AB, Pieper B, Higashi H, Sacks FM, Aikawa M, Singh SA. Automation of PRM-dependent D3-Leu tracer enrichment in HDL to study the metabolism of apoA-I, LCAT and other apolipoproteins. Proteomics. 2017 01; 17(1-2). PMID: 27862954.
    Citations:    Fields:    Translation:Humans
  10. Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh WW, Halu A, Yamada I, Yoshida H, Hara T, Wei M, Inoue N, Fukuda D, Mojcher A, Mattson PC, Barabási AL, Boothby M, Aikawa E, Singh SA, Aikawa M. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Nat Commun. 2016 10 31; 7:12849. PMID: 27796300.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  11. Singh SA, Aikawa E, Aikawa M. Current Trends and Future Perspectives of State-of-the-Art Proteomics Technologies Applied to Cardiovascular Disease Research. Circ J. 2016 Jul 25; 80(8):1674-83. PMID: 27430298.
    Citations: 1     Fields:    Translation:HumansAnimals
  12. Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016 Apr 01; 126(4):1323-36. PMID: 26950419; PMCID: PMC4811143.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  13. Singh SA, Andraski AB, Pieper B, Goh W, Mendivil CO, Sacks FM, Aikawa M. Multiple apolipoprotein kinetics measured in human HDL by high-resolution/accurate mass parallel reaction monitoring. J Lipid Res. 2016 Apr; 57(4):714-28. PMID: 26862155; PMCID: PMC4808760.
    Citations: 6     Fields:    Translation:HumansCells
  14. Singh SA, Miyosawa K, Aikawa M. Mass spectrometry meets the challenge of understanding the complexity of the lipoproteome: recent findings regarding proteins involved in dyslipidemia and cardiovascular disease. Expert Rev Proteomics. 2015; 12(5):519-32. PMID: 26325144.
    Citations: 3     Fields:    Translation:HumansAnimals
  15. Ricchiuto P, Iwata H, Yabusaki K, Yamada I, Pieper B, Sharma A, Aikawa M, Singh SA. mIMT-visHTS: A novel method for multiplexing isobaric mass tagged datasets with an accompanying visualization high throughput screening tool for protein profiling. J Proteomics. 2015 Oct 14; 128:132-40. PMID: 26232111.
    Citations: 2     Fields:    Translation:AnimalsCells
  16. Miyosawa K, Watanabe Y, Murakami K, Murakami T, Shibata H, Iwashita M, Yamazaki H, Yamazaki K, Ohgiya T, Shibuya K, Mizuno K, Tanabe S, Singh SA, Aikawa M. New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism. Am J Physiol Endocrinol Metab. 2015 Jul 15; 309(2):E177-90. PMID: 26015437.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  17. Hutcheson JD, Goettsch C, Pham T, Iwashita M, Aikawa M, Singh SA, Aikawa E. Enrichment of calcifying extracellular vesicles using density-based ultracentrifugation protocol. J Extracell Vesicles. 2014; 3:25129. PMID: 25491249; PMCID: PMC4261240.
    Citations: 10     
  18. Singh SA, Winter D, Kirchner M, Chauhan R, Ahmed S, Ozlu N, Tzur A, Steen JA, Steen H. Co-regulation proteomics reveals substrates and mechanisms of APC/C-dependent degradation. EMBO J. 2014 Feb 18; 33(4):385-99. PMID: 24510915; PMCID: PMC3989644.
    Citations: 17     Fields:    Translation:HumansCells
  19. Singh SA, Winter D, Bilimoria PM, Bonni A, Steen H, Steen JA. FLEXIQinase, a mass spectrometry-based assay, to unveil multikinase mechanisms. Nat Methods. 2012 Apr 08; 9(5):504-8. PMID: 22484849; PMCID: PMC3595540.
    Citations: 10     Fields:    Translation:Cells
  20. Singh S, Springer M, Steen J, Kirschner MW, Steen H. FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. J Proteome Res. 2009 May; 8(5):2201-10. PMID: 19344176; PMCID: PMC2868505.
    Citations: 27     Fields:    Translation:HumansCells
  21. Wang Z, Dong G, Singh S, Steen H, Li J. A simple and effective method for detecting phosphopeptides for phosphoproteomic analysis. J Proteomics. 2009 Jul 21; 72(5):831-5. PMID: 19341826.
    Citations: 5     Fields:    Translation:AnimalsCells
  22. Singh S, Stavrinides J, Christendat D, Guttman DS. A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass. Mol Biol Evol. 2008 Oct; 25(10):2221-32. PMID: 18669580.
    Citations: 3     Fields:    Translation:Cells
  23. Singh SA, Christendat D. Structure of Arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase and implications for metabolic channeling in the shikimate pathway. Biochemistry. 2006 Jun 27; 45(25):7787-96. PMID: 16784230.
    Citations: 14     Fields:    Translation:AnimalsCells
  24. Bonvin J, Aponte RA, Marcantonio M, Singh S, Christendat D, Turnbull JL. Biochemical characterization of prephenate dehydrogenase from the hyperthermophilic bacterium Aquifex aeolicus. Protein Sci. 2006 Jun; 15(6):1417-32. PMID: 16731976; PMCID: PMC2265095.
    Citations: 7     Fields:    Translation:Cells
  25. Sun W, Singh S, Zhang R, Turnbull JL, Christendat D. Crystal structure of prephenate dehydrogenase from Aquifex aeolicus. Insights into the catalytic mechanism. J Biol Chem. 2006 May 05; 281(18):12919-28. PMID: 16513644.
    Citations: 7     Fields:    Translation:Cells
  26. Singh S, Korolev S, Koroleva O, Zarembinski T, Collart F, Joachimiak A, Christendat D. Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae. J Biol Chem. 2005 Apr 29; 280(17):17101-8. PMID: 15735308; PMCID: PMC2792007.
    Citations: 9     Fields:    Translation:Cells
  27. Hardtke CS, Ckurshumova W, Vidaurre DP, Singh SA, Stamatiou G, Tiwari SB, Hagen G, Guilfoyle TJ, Berleth T. Overlapping and non-redundant functions of the Arabidopsis auxin response factors MONOPTEROS and NONPHOTOTROPIC HYPOCOTYL 4. Development. 2004 Mar; 131(5):1089-100. PMID: 14973283.
    Citations: 92     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.