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Chandra Chur Ghosh, Ph.D.

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  1. R03AI138083 (GHOSH, CHANDRA C.) Feb 12, 2018 - Jan 31, 2020
    NIH/NIAID
    Role of the Tie2-Angpt axis in the regulation of endothelial cell immunogenicity
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Widmeier E, Airik M, Hugo H, Schapiro D, Wedel J, Ghosh CC, Nakayama M, Schneider R, Awad AM, Nag A, Cho J, Schueler M, Clarke CF, Airik R, Hildebrandt F. Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice. J Am Soc Nephrol. 2019 Feb 08. PMID: 30737270.
    Citations:    
  2. Rokhzan R, Ghosh CC, Schaible N, Notbohm J, Yoshie H, Ehrlicher AJ, Higgins SJ, Zhang R, Haller H, Hardin CC, David S, Parikh SM, Krishnan R. Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function. Lab Invest. 2019 Jan; 99(1):138-145. PMID: 30310180.
    Citations:    Fields:    
  3. Thamm K, Schrimpf C, Retzlaff J, Idowu TO, van Meurs M, Zijlstra JG, Ghosh CC, Zeitvogel J, Werfel TA, Haller H, Parikh SM, David S. Molecular Regulation of Acute Tie2 Suppression in Sepsis. Crit Care Med. 2018 Sep; 46(9):e928-e936. PMID: 29979219.
    Citations:    Fields:    
  4. Retzlaff J, Thamm K, Ghosh CC, Ziegler W, Haller H, Parikh SM, David S. Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis. Sci Rep. 2017 03 09; 7:44113. PMID: 28276491.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  5. Sangwung P, Zhou G, Nayak L, Chan ER, Kumar S, Kang DW, Zhang R, Liao X, Lu Y, Sugi K, Fujioka H, Shi H, Lapping SD, Ghosh CC, Higgins SJ, Parikh SM, Jo H, Jain MK. KLF2 and KLF4 control endothelial identity and vascular integrity. JCI Insight. 2017 02 23; 2(4):e91700. PMID: 28239661.
    Citations: 10     Fields:    
  6. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016 Apr; 22(4):421-6. PMID: 26950361.
    Citations: 58     Fields:    Translation:HumansAnimals
  7. Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F, Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM. Gene control of tyrosine kinase TIE2 and vascular manifestations of infections. Proc Natl Acad Sci U S A. 2016 Mar 01; 113(9):2472-7. PMID: 26884170.
    Citations: 17     Fields:    Translation:Animals
  8. Ghosh CC, Thamm K, Berghelli AV, Schrimpf C, Maski MR, Abid T, Milam KE, Rajakumar A, Santel A, Kielstein JT, Ahmed A, Thickett D, Wang K, Chase M, Donnino MW, Aird WC, Haller H, David S, Parikh SM. Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis. Crit Care Med. 2015 Jul; 43(7):e230-40. PMID: 25855898.
    Citations: 10     Fields:    Translation:HumansAnimals
  9. Ghosh CC, Mukherjee A, David S, Milam KE, Hunter JT, Parikh SM. Angiopoietin-1 requires oxidant signaling through p47phox to promote endothelial barrier defense. PLoS One. 2015; 10(3):e0119577. PMID: 25761062.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  10. Aisiku O, Peters CG, De Ceunynck K, Ghosh CC, Dilks JR, Fustolo-Gunnink SF, Huang M, Dockendorff C, Parikh SM, Flaumenhaft R. Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar. Blood. 2015 Mar 19; 125(12):1976-85. PMID: 25587041.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  11. Stiehl T, Thamm K, Kaufmann J, Schaeper U, Kirsch T, Haller H, Santel A, Ghosh CC, Parikh SM, David S. Lung-targeted RNA interference against angiopoietin-2 ameliorates multiple organ dysfunction and death in sepsis. Crit Care Med. 2014 Oct; 42(10):e654-62. PMID: 25083983.
    Citations: 18     Fields:    Translation:Animals
  12. Xie Z, Ghosh CC, Parikh SM, Druey KM. Mechanistic classification of the systemic capillary leak syndrome: Clarkson disease. Am J Respir Crit Care Med. 2014 May 01; 189(9):1145-7. PMID: 24787070.
    Citations: 10     Fields:    Translation:Humans
  13. Guha PP, David SA, Ghosh CC. Detecting Tie2, an endothelial growth factor receptor, by using immunohistochemistry in mouse lungs. Methods Mol Biol. 2014; 1172:201-8. PMID: 24908307.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Xie Z, Chan E, Yin Y, Ghosh CC, Wisch L, Nelson C, Young M, Parikh SM, Druey KM. Inflammatory Markers of the Systemic Capillary Leak Syndrome (Clarkson Disease). J Clin Cell Immunol. 2014; 5:1000213. PMID: 25405070.
    Citations: 10     
  15. David S, Mukherjee A, Ghosh CC, Yano M, Khankin EV, Wenger JB, Karumanchi SA, Shapiro NI, Parikh SM. Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*. Crit Care Med. 2012 Nov; 40(11):3034-41. PMID: 22890252.
    Citations: 51     Fields:    Translation:HumansAnimals
  16. Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM. Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):10024-9. PMID: 22665799.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  17. Xie Z, Ghosh CC, Patel R, Iwaki S, Gaskins D, Nelson C, Jones N, Greipp PR, Parikh SM, Druey KM. Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). Blood. 2012 May 03; 119(18):4321-32. PMID: 22411873.
    Citations: 31     Fields:    Translation:HumansCells
  18. David S, Ghosh CC, Mukherjee A, Parikh SM. Angiopoietin-1 requires IQ domain GTPase-activating protein 1 to activate Rac1 and promote endothelial barrier defense. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2643-52. PMID: 21885850.
    Citations: 31     Fields:    Translation:HumansCells
  19. David S, Ghosh CC, Kümpers P, Shushakova N, Van Slyke P, Khankin EV, Karumanchi SA, Dumont D, Parikh SM. Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol. 2011 Jun; 300(6):L851-62. PMID: 21421750.
    Citations: 34     Fields:    Translation:HumansAnimals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.