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Lynn Turner Matthews, M.D.


I became interested in risk reduction for HIV-serodiscordant couples who choose to conceive while working as an internal medicine resident in Rwanda (2006) and as a medical consultant in South Africa (2008). I met many HIV-infected men and women who were eager to conceive children, but did not know how to do this without infecting his/her partner. A young, fertile population in HIV-endemic regions demands HIV-prevention strategies that address couples’ reproductive goals. Antiretrovirals as prevention (antiretroviral treatment for the positive partner and pre-exposure prophylaxis (PrEP) for the uninfected partner) are particularly exciting options for periconception risk reduction. Using behavioral science to understand sexual and reproductive behavior in HIV-endemic settings, I plan to develop and implement feasible, acceptable safer conception interventions for HIV-affected couples.

In 2009, I published a harm-reduction approach on minimizing sexual HIV transmission while respecting couples’ reproductive choices (AIDS and Behavior). In 2011, I received a K23 award (NIMH, 1° mentor Bangsberg) to investigate fertility desire, pregnancy incidence, and ARV adherence in a cohort of women on ART and among women enrolled in the Partners PrEP trial; and develop and pilot a reproductive counseling intervention to minimize HIV transmission risk among serodiscordant couples who choose to conceive. I also secured R03 funding (NICHD) to carry out a mixed-methods study to explore provider-patient discussion of fertility plans and safer conception or contraception options in KwaZulu-Natal, South Africa. Through mixed-methods work in South Africa, I found that people living with HIV prioritize conception over HIV-transmission risks and are eager for safer conception advice, that men make most conception decisions, that most men and women don’t know their partner’s HIV status, and that healthcare workers lack safer conception knowledge (AIDS and Behav 2011, Repro Health Matters 2012, Infect Dis Obst & Gyn 2012, BMC Public Health 2014, JAIDS in press.) This led to R34-funding to develop an intervention for HIV-infected men who choose to conceive with at-risk partners. I pursue parallel work in Uganda where a total fertility rate of 6.1 children per woman makes safer conception essential (PLoS ONE 2013, AIDS 2014).

I also spend 20% of my time as an infectious disease attending at MGH on teaching services that include fellows, residents, and medical students.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH108412 (MATTHEWS, LYNN TURNER) Aug 25, 2016 - Jun 30, 2021
    PrEP uptake/adherence to reduce periconception HIV risk for South African women
    Role: Principal Investigator
  2. R34MH100948 (MATTHEWS, LYNN TURNER) Feb 1, 2014 - Jan 31, 2017
    ART-based safer conception for HIV+ South African men who want to have children
    Role: Principal Investigator
  3. R03HD072602 (MATTHEWS, LYNN TURNER) May 1, 2012 - Apr 30, 2014
    Assessing providers'reproductive counseling practice for South Africans with HIV
    Role: Principal Investigator
  4. K23MH095655 (MATTHEWS, LYNN TURNER) Jul 26, 2011 - Apr 30, 2016
    Periconception HIV risk reduction for HIV-discordant couples in Uganda
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Young CR, Kaida A, Kabakyenga J, Muyindike W, Musinguzi N, Martin JN, Hunt PW, Bangsberg DR, Haberer JE, Matthews LT. Prevalence and correlates of physical and sexual intimate partner violence among women living with HIV in Uganda. PLoS One. 2018; 13(8):e0202992. PMID: 30148854.
    View in: PubMed
  2. Matthews LT, Beyeza-Kashesya J, Cooke I, Davies N, Heffron R, Kaida A, Kinuthia J, Mmeje O, Semprini AE, Weber S. Consensus statement: Supporting Safer Conception and Pregnancy For Men And Women Living with and Affected by HIV. AIDS Behav. 2018 Jun; 22(6):1713-1724. PMID: 28501964.
    View in: PubMed
  3. Khidir H, Psaros C, Greener L, O'Neil K, Mathenjwa M, Mosery FN, Moore L, Harrison A, Bangsberg DR, Smit JA, Safren SA, Matthews LT. Developing a Safer Conception Intervention for Men Living with HIV in South Africa. AIDS Behav. 2018 Jun; 22(6):1725-1735. PMID: 28194587.
    View in: PubMed
  4. Greener R, Milford C, Bajunirwe F, Mosery FN, Ng CK, Rifkin R, Kastner J, Pillay L, Kaida A, Bangsberg DR, Smit JA, Matthews LT. Healthcare providers' understanding of HIV serodiscordance in South Africa and Uganda: implications for HIV prevention in sub-Saharan Africa. Afr J AIDS Res. 2018 Jul; 17(2):137-144. PMID: 29745290.
    View in: PubMed
  5. Dunkley E, Ashaba S, Burns B, O'Neil K, Sanyu N, Akatukwasa C, Kastner J, Berry NS, Psaros C, Matthews LT, Kaida A. "I beg you…breastfeed the baby, things changed": infant feeding experiences among Ugandan mothers living with HIV in the context of evolving guidelines to prevent postnatal transmission. BMC Public Health. 2018 01 29; 18(1):188. PMID: 29378548.
    View in: PubMed
  6. Psaros C, Milford C, Smit JA, Greener L, Mosery N, Matthews LT, Harrison A, Gordon JR, Mimiaga M, Bangsberg DR, Safren SA. HIV Prevention Among Young Women in South Africa: Understanding Multiple Layers of Risk. Arch Sex Behav. 2018 Oct; 47(7):1969-1982. PMID: 29134422.
    View in: PubMed
  7. Matthews LT, Burns BF, Bajunirwe F, Kabakyenga J, Bwana M, Ng C, Kastner J, Kembabazi A, Sanyu N, Kusasira A, Haberer JE, Bangsberg DR, Kaida A. Beyond HIV-serodiscordance: Partnership communication dynamics that affect engagement in safer conception care. PLoS One. 2017; 12(9):e0183131. PMID: 28880892.
    View in: PubMed
  8. Bhatia DS, Harrison AD, Kubeka M, Milford C, Kaida A, Bajunirwe F, Wilson IB, Psaros C, Safren SA, Bangsberg DR, Smit JA, Matthews LT. The Role of Relationship Dynamics and Gender Inequalities As Barriers to HIV-Serostatus Disclosure: Qualitative Study among Women and Men Living with HIV in Durban, South Africa. Front Public Health. 2017; 5:188. PMID: 28824897.
    View in: PubMed
  9. Pollock LC, Weber S, Kaida A, Matthews LT, Seidman DL. HIV-affected couples and individuals who desire children should be offered options for safer conception. J Int AIDS Soc. 2017 07 26; 20(1):22155. PMID: 28741333.
    View in: PubMed
  10. Miller K, Muyindike W, Matthews LT, Kanyesigye M, Siedner MJ. Program Implementation of Option B+ at a President's Emergency Plan for AIDS Relief-Supported HIV Clinic Improves Clinical Indicators But Not Retention in Care in Mbarara, Uganda. AIDS Patient Care STDS. 2017 08; 31(8):335-341. PMID: 28650703.
    View in: PubMed
  11. Ashaba S, Kaida A, Burns BF, O'Neil K, Dunkley E, Psaros C, Kastner J, Tsai AC, Bangsberg DR, Matthews LT. Understanding coping strategies during pregnancy and the postpartum period: a qualitative study of women living with HIV in rural Uganda. BMC Pregnancy Childbirth. 2017 May 08; 17(1):138. PMID: 28482821.
    View in: PubMed
  12. Ashaba S, Kaida A, Coleman JN, Burns BF, Dunkley E, O'Neil K, Kastner J, Sanyu N, Akatukwasa C, Bangsberg DR, Matthews LT, Psaros C. Psychosocial challenges facing women living with HIV during the perinatal period in rural Uganda. PLoS One. 2017; 12(5):e0176256. PMID: 28459866.
    View in: PubMed
  13. Davies NE, Matthews LT, Crankshaw TL, Cooper D, Schwartz SR. Supporting HIV prevention and reproductive goals in an HIV-endemic setting: taking safer conception services from policy to practice in South Africa. J Int AIDS Soc. 2017 03 08; 20(Suppl 1):21271. PMID: 28361506.
    View in: PubMed
  14. Tsai AC, Kohrt BA, Matthews LT, Betancourt TS, Lee JK, Papachristos AV, Weiser SD, Dworkin SL. Promises and pitfalls of data sharing in qualitative research. Soc Sci Med. 2016 11; 169:191-198. PMID: 27535900.
    View in: PubMed
  15. Heffron R, Pintye J, Matthews LT, Weber S, Mugo N. PrEP as Peri-conception HIV Prevention for Women and Men. Curr HIV/AIDS Rep. 2016 06; 13(3):131-9. PMID: 26993627.
    View in: PubMed
  16. Matthews LT, Ribaudo HB, Kaida A, Bennett K, Musinguzi N, Siedner MJ, Kabakyenga J, Hunt PW, Martin JN, Boum Y, Haberer JE, Bangsberg DR. HIV-Infected Ugandan Women on Antiretroviral Therapy Maintain HIV-1 RNA Suppression Across Periconception, Pregnancy, and Postpartum Periods. J Acquir Immune Defic Syndr. 2016 Apr 01; 71(4):399-406. PMID: 26495883; PMCID: PMC4943862 [Available on 04/01/17].
  17. Matthews LT, Bajunirwe F, Kastner J, Sanyu N, Akatukwasa C, Ng C, Rifkin R, Milford C, Moore L, Wilson IB, Bangsberg DR, Smit JA, Kaida A. "I Always Worry about What Might Happen Ahead": Implementing Safer Conception Services in the Current Environment of Reproductive Counseling for HIV-Affected Men and Women in Uganda. Biomed Res Int. 2016; 2016:4195762. PMID: 27051664; PMCID: PMC4802028.
  18. Matthews LT, Smit JA, Moore L, Milford C, Greener R, Mosery FN, Ribaudo H, Bennett K, Crankshaw TL, Kaida A, Psaros C, Safren SA, Bangsberg DR. Periconception HIV Risk Behavior Among Men and Women Reporting HIV-Serodiscordant Partners in KwaZulu-Natal, South Africa. AIDS Behav. 2015 Dec; 19(12):2291-303. PMID: 26080688.
    View in: PubMed
  19. Matthews LT, Moore L, Milford C, Greener R, Mosery FN, Rifkin R, Psaros C, Safren SA, Harrison A, Wilson IB, Bangsberg DR, Smit JA. "If I don't use a condom … I would be stressed in my heart that I've done something wrong": Routine Prevention Messages Preclude Safer Conception Counseling for HIV-Infected Men and Women in South Africa. AIDS Behav. 2015 Sep; 19(9):1666-75. PMID: 25711300; PMCID: PMC4550563.
  20. Ciaranello AL, Matthews LT. Safer Conception Strategies for HIV-Serodiscordant Couples: How Safe Is Safe Enough? J Infect Dis. 2015 Nov 15; 212(10):1525-8. PMID: 26092857; PMCID: PMC4621252.
  21. Nieves CI, Kaida A, Seage GR, Kabakyenga J, Muyindike W, Boum Y, Mocello AR, Martin JN, Hunt PW, Haberer JE, Bangsberg DR, Matthews LT. The influence of partnership on contraceptive use among HIV-infected women accessing antiretroviral therapy in rural Uganda. Contraception. 2015 Aug; 92(2):152-9. PMID: 25983013; PMCID: PMC4941236.
  22. Kaida A, Matthews LT, Ashaba S, Tsai AC, Kanters S, Robak M, Psaros C, Kabakyenga J, Boum Y, Haberer JE, Martin JN, Hunt PW, Bangsberg DR. Depression during pregnancy and the postpartum among HIV-infected women on antiretroviral therapy in Uganda. J Acquir Immune Defic Syndr. 2014 Dec 01; 67 Suppl 4:S179-87. PMID: 25436816; PMCID: PMC4251908.
  23. Matthews LT, Milford C, Kaida A, Ehrlich MJ, Ng C, Greener R, Mosery FN, Harrison A, Psaros C, Safren SA, Bajunirwe F, Wilson IB, Bangsberg DR, Smit JA. Lost opportunities to reduce periconception HIV transmission: safer conception counseling by South African providers addresses perinatal but not sexual HIV transmission. J Acquir Immune Defic Syndr. 2014 Dec 01; 67 Suppl 4:S210-7. PMID: 25436820; PMCID: PMC4251914.
  24. Kaida A, Kastner J, Ng C, Sanyu N, Kusasira A, Kabakyenga J, Bangsberg DR, Matthews LT. Barriers and Promoters to Uptake of Safer Conception Strategies among HIV-serodiscordant Couples with Fertility Intention in Mbarara, Uganda. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A61-2. PMID: 25357899.
    View in: PubMed
  25. Kastner J, Matthews LT, Flavia N, Bajunirwe F, Erikson S, Berry NS, Kaida A. Antiretroviral Therapy Helps HIV-Positive Women Navigate Social Expectations for and Clinical Recommendations against Childbearing in Uganda. AIDS Res Treat. 2014; 2014:626120. PMID: 25328693; PMCID: PMC4189848.
  26. Matthews LT, Heffron R, Mugo NR, Cohen CR, Hendrix CW, Celum C, Bangsberg DR, Baeten JM. High medication adherence during periconception periods among HIV-1-uninfected women participating in a clinical trial of antiretroviral pre-exposure prophylaxis. J Acquir Immune Defic Syndr. 2014 Sep 01; 67(1):91-7. PMID: 25118795; PMCID: PMC4149628.
  27. Matthews LT, Moore L, Crankshaw TL, Milford C, Mosery FN, Greener R, Psaros C, Safren SA, Bangsberg DR, Smit JA. South Africans with recent pregnancy rarely know partner's HIV serostatus: implications for serodiscordant couples interventions. BMC Public Health. 2014 Aug 14; 14:843. PMID: 25124267; PMCID: PMC4246447.
  28. Mimiaga MJ, Closson EF, Safren SA, Mabude Z, Mosery N, Taylor SW, Perez-Brumer A, Matthews LT, Psaros C, Harrison A, Grelotti DJ, Bangsberg DR, Smit JA. Inkwari: an emerging high-risk place potentiating hiv spread among young adults in a hyper-endemic South African setting. Arch Sex Behav. 2015 Feb; 44(2):307-15. PMID: 25091214; PMCID: PMC4441263.
  29. Mugo NR, Hong T, Celum C, Donnell D, Bukusi EA, John-Stewart G, Wangisi J, Were E, Heffron R, Matthews LT, Morrison S, Ngure K, Baeten JM. Pregnancy incidence and outcomes among women receiving preexposure prophylaxis for HIV prevention: a randomized clinical trial. JAMA. 2014 Jul 23-30; 312(4):362-71. PMID: 25038355; PMCID: PMC4362516.
  30. Grelotti DJ, Closson EF, Smit JA, Mabude Z, Matthews LT, Safren SA, Bangsberg DR, Mimiaga MJ. Whoonga: potential recreational use of HIV antiretroviral medication in South Africa. AIDS Behav. 2014 Mar; 18(3):511-8. PMID: 23955659; PMCID: PMC3926908.
  31. Tsai AC, Scott JA, Hung KJ, Zhu JQ, Matthews LT, Psaros C, Tomlinson M. Reliability and validity of instruments for assessing perinatal depression in African settings: systematic review and meta-analysis. PLoS One. 2013; 8(12):e82521. PMID: 24340036; PMCID: PMC3858316.
  32. Matthews LT, Kaida A, Kanters S, Byakwagamd H, Mocello AR, Muzoora C, Kembabazi A, Haberer JE, Martin JN, Bangsberg DR, Hunt PW. HIV-infected women on antiretroviral treatment have increased mortality during pregnant and postpartum periods. AIDS. 2013 Oct; 27 Suppl 1:S105-12. PMID: 24088676; PMCID: PMC4142689.
  33. Kaida A, Matthews LT, Kanters S, Kabakyenga J, Muzoora C, Mocello AR, Martin JN, Hunt P, Haberer J, Hogg RS, Bangsberg DR. Correction: Incidence and Predictors of Pregnancy among a Cohort of HIV-Positive Women Initiating Antiretroviral Therapy in Mbarara, Uganda. PLoS One. 2013; 8(6). PMID: 29161730.
    View in: PubMed
  34. Kaida A, Matthews LT, Kanters S, Kabakyenga J, Muzoora C, Mocello AR, Martin JN, Hunt P, Haberer J, Hogg RS, Bangsberg DR. Incidence and predictors of pregnancy among a cohort of HIV-positive women initiating antiretroviral therapy in Mbarara, Uganda. PLoS One. 2013; 8(5):e63411. PMID: 23704906; PMCID: PMC3660357.
  35. Matthews LT, Sibeko S, Mansoor LE, Yende-Zuma N, Bangsberg DR, Karim QA. Women with pregnancies had lower adherence to 1% tenofovir vaginal gel as HIV preexposure prophylaxis in CAPRISA 004, a phase IIB randomized-controlled trial. PLoS One. 2013; 8(3):e56400. PMID: 23472071; PMCID: PMC3589407.
  36. Baylor A, Muzoora C, Bwana M, Kembabazi A, Haberer JE, Matthews LT, Tsai AC, Hunt PW, Martin JN, Bangsberg DR. Dissemination of research findings to research participants living with HIV in rural Uganda: challenges and rewards. PLoS Med. 2013; 10(3):e1001397. PMID: 23472055; PMCID: PMC3589331.
  37. Matthews LT, Crankshaw T, Giddy J, Kaida A, Smit JA, Ware NC, Bangsberg DR. Reproductive decision-making and periconception practices among HIV-positive men and women attending HIV services in Durban, South Africa. AIDS Behav. 2013 Feb; 17(2):461-70. PMID: 22038045; PMCID: PMC3560938.
  38. Crankshaw TL, Matthews LT, Giddy J, Kaida A, Ware NC, Smit JA, Bangsberg DR. A conceptual framework for understanding HIV risk behavior in the context of supporting fertility goals among HIV-serodiscordant couples. Reprod Health Matters. 2012 Dec; 20(39 Suppl):50-60. PMID: 23177680; PMCID: PMC3608509.
  39. Matthews LT, Smit JA, Cu-Uvin S, Cohan D. Antiretrovirals and safer conception for HIV-serodiscordant couples. Curr Opin HIV AIDS. 2012 Nov; 7(6):569-78. PMID: 23032734; PMCID: PMC3695736.
  40. Muyindike W, Fatch R, Steinfield R, Matthews LT, Musinguzi N, Emenyonu NI, Martin JN, Hahn JA. Contraceptive use and associated factors among women enrolling into HIV care in southwestern Uganda. Infect Dis Obstet Gynecol. 2012; 2012:340782. PMID: 23082069; PMCID: PMC3469089.
  41. Matthews LT, Crankshaw T, Giddy J, Kaida A, Psaros C, Ware NC, Smit JA, Bangsberg DR. Reproductive counseling by clinic healthcare workers in Durban, South Africa: perspectives from HIV-infected men and women reporting serodiscordant partners. Infect Dis Obstet Gynecol. 2012; 2012:146348. PMID: 22927713; PMCID: PMC3426202.
  42. Matthews LT, Ribaudo HJ, Parekh NK, Chen JY, Binda K, Ogwu A, Makhema J, Souda S, Lockman S, Essex M, Shapiro RL. Birth weight for gestational age norms for a large cohort of infants born to HIV-negative women in Botswana compared with norms for U.S.-born black infants. BMC Pediatr. 2011 Dec 16; 11:115. PMID: 22176889; PMCID: PMC3271964.
  43. Matthews LT, Giddy J, Ghebremichael M, Hampton J, Guarino AJ, Ewusi A, Carver E, Axten K, Geary MC, Gandhi RT, Bangsberg DR. A risk-factor guided approach to reducing lactic acidosis and hyperlactatemia in patients on antiretroviral therapy. PLoS One. 2011 Apr 11; 6(4):e18736. PMID: 21494566; PMCID: PMC3073990.
  44. Matthews LT, Baeten JM, Celum C, Bangsberg DR. Periconception pre-exposure prophylaxis to prevent HIV transmission: benefits, risks, and challenges to implementation. AIDS. 2010 Aug 24; 24(13):1975-82. PMID: 20679759; PMCID: PMC3773599.
  45. Murphy RA, Sunpath H, Lu Z, Chelin N, Losina E, Gordon M, Ross D, Ewusi AD, Matthews LT, Kuritzkes DR, Marconi VC. Outcomes after virologic failure of first-line ART in South Africa. AIDS. 2010 Apr 24; 24(7):1007-12. PMID: 20397305; PMCID: PMC2902159.
  46. Matthews LT, Mukherjee JS. Strategies for harm reduction among HIV-affected couples who want to conceive. AIDS Behav. 2009 Jun; 13 Suppl 1:5-11. PMID: 19347575.
    View in: PubMed
  47. Di Mascio M, Sereti I, Matthews LT, Natarajan V, Adelsberger J, Lempicki R, Yoder C, Jones E, Chow C, Metcalf JA, Sidorov IA, Dimitrov DS, Polis MA, Kovacs JA. Naïve T-cell dynamics in human immunodeficiency virus type 1 infection: effects of highly active antiretroviral therapy provide insights into the mechanisms of naive T-cell depletion. J Virol. 2006 Mar; 80(6):2665-74. PMID: 16501076; PMCID: PMC1395465.
  48. Matthews L, Chapman S, Ramchandani MS, Lane HC, Davey RT, Sereti I. BAY 50-4798, a novel, high-affinity receptor-specific recombinant interleukin-2 analog, induces dose-dependent increases in CD25 expression and proliferation among unstimulated, human peripheral blood mononuclear cells in vitro. Clin Immunol. 2004 Dec; 113(3):248-55. PMID: 15507389.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.