Harvard Catalyst Profiles

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Matthew L. Steinhauser, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK120659 (STEINHAUSER, MATTHEW) Feb 26, 2019 - Jan 31, 2023
    Functional evaluation of a new GWAS locus that links visceral adiposity and type 2 diabetes
    Role: Principal Investigator
  2. DP2CA216362 (STEINHAUSER, MATTHEW) Sep 20, 2016 - Aug 31, 2021
    A new modality to image tumor metabolic heterogeneity at subcellular resolution
    Role: Principal Investigator
  3. R03DK106477 (STEINHAUSER, MATTHEW) Jul 1, 2015 - Jun 30, 2017
    Impaired progenitor self-renewal and age-dependent loss of fat plasticity
    Role: Principal Investigator
  4. K08DK090147 (STEINHAUSER, MATTHEW) Jan 1, 2012 - Dec 31, 2016
    Stable isotope-based fate mapping to quantify adipogenesis in obesity
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Weeks O, Bossé GD, Oderberg IM, Akle S, Houvras Y, Wrighton PJ, LaBella K, Iversen I, Tavakoli S, Adatto I, Schwartz A, Kloosterman D, Tsomides A, Charness ME, Peterson RT, Steinhauser ML, Fazeli PK, Goessling W. Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. J Clin Invest. 2020 May 01; 130(5):2252-2269. PMID: 32202514.
  2. Narendra DP, Guillermier C, Gyngard F, Huang X, Ward ME, Steinhauser ML. Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover. J Cell Biol. 2020 Jan 06; 219(1). PMID: 31719114.
  3. Liu H, Zhang CH, Ammanamanchi N, Suresh S, Lewarchik C, Rao K, Uys GM, Han L, Abrial M, Yimlamai D, Ganapathy B, Guillermier C, Chen N, Khaladkar M, Spaethling J, Eberwine JH, Kim J, Walsh S, Choudhury S, Little K, Francis K, Sharma M, Viegas M, Bais A, Kostka D, Ding J, Bar-Joseph Z, Wu Y, Yechoor V, Moulik M, Johnson J, Weinberg J, Reyes-Múgica M, Steinhauser ML, Kühn B. Control of cytokinesis by ß-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment. Sci Transl Med. 2019 10 09; 11(513). PMID: 31597755.
  4. Fazeli PK, Lee H, Steinhauser ML. Aging Is a Powerful Risk Factor for Type 2 Diabetes Mellitus Independent of Body Mass Index. Gerontology. 2020; 66(2):209-210. PMID: 31505500.
  5. Guillermier C, Doherty SP, Whitney AG, Babaev VR, Linton MF, Steinhauser ML, Brown JD. Imaging mass spectrometry reveals heterogeneity of proliferation and metabolism in atherosclerosis. JCI Insight. 2019 06 06; 4(11). PMID: 31167964.
  6. Cox AG, Tsomides A, Yimlamai D, Hwang KL, Miesfeld J, Galli GG, Fowl BH, Fort M, Ma KY, Sullivan MR, Hosios AM, Snay E, Yuan M, Brown KK, Lien EC, Chhangawala S, Steinhauser ML, Asara JM, Houvras Y, Link B, Vander Heiden MG, Camargo FD, Goessling W. Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. EMBO J. 2018 11 15; 37(22). PMID: 30348863.
    Citations:    Fields:    
  7. Zhang Y, Federation AJ, Kim S, O'Keefe JP, Lun M, Xiang D, Brown JD, Steinhauser ML. Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity. J Clin Invest. 2018 11 01; 128(11):4898-4911. PMID: 30277475.
    Citations:    Fields:    
  8. Steinhauser ML, Olenchock BA, O'Keefe J, Lun M, Pierce KA, Lee H, Pantano L, Klibanski A, Shulman GI, Clish CB, Fazeli PK. The circulating metabolome of human starvation. JCI Insight. 2018 08 23; 3(16). PMID: 30135314.
    Citations:    Fields:    
  9. Vujic A, Lerchenmüller C, Wu TD, Guillermier C, Rabolli CP, Gonzalez E, Senyo SE, Liu X, Guerquin-Kern JL, Steinhauser ML, Lee RT, Rosenzweig A. Exercise induces new cardiomyocyte generation in the adult mammalian heart. Nat Commun. 2018 04 25; 9(1):1659. PMID: 29695718.
  10. Wildburger NC, Gyngard F, Guillermier C, Patterson BW, Elbert D, Mawuenyega KG, Schneider T, Green K, Roth R, Schmidt RE, Cairns NJ, Benzinger TLS, Steinhauser ML, Bateman RJ. Amyloid-ß Plaques in Clinical Alzheimer's Disease Brain Incorporate Stable Isotope Tracer In Vivo and Exhibit Nanoscale Heterogeneity. Front Neurol. 2018; 9:169. PMID: 29623063.
  11. Lu J, Baccei A, Lummertz da Rocha E, Guillermier C, McManus S, Finney LA, Zhang C, Steinhauser ML, Li H, Lerou PH. Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm. Stem Cell Res. 2018 04; 28:48-55. PMID: 29427839.
    Citations:    Fields:    Translation:HumansCells
  12. Guillermier C, Poczatek JC, Taylor WR, Steinhauser ML. Quantitative imaging of deuterated metabolic tracers in biological tissues with nanoscale secondary ion mass spectrometry. Int J Mass Spectrom. 2017 11; 422:42-50. PMID: 29276427.
  13. Guillermier C, Fazeli PK, Kim S, Lun M, Zuflacht JP, Milian J, Lee H, Francois-Saint-Cyr H, Horreard F, Larson D, Rosen ED, Lee RT, Lechene CP, Steinhauser ML. Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity. JCI Insight. 2017 03 09; 2(5):e90349. PMID: 28289709.
    Citations: 1     Fields:    
  14. Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O'Connell JR, Parihar A, Peralta JM, Smith AV, Zhang Y, Homuth G, Kissebah AH, Kullberg J, Laqua R, Launer LJ, Nauck M, Olivier M, Peyser PA, Terry JG, Wojczynski MK, Yao J, Bielak LF, Blangero J, Borecki IB, Bowden DW, Carr JJ, Czerwinski SA, Ding J, Friedrich N, Gudnason V, Harris TB, Ingelsson E, Johnson AD, Kardia SL, Langefeld CD, Lind L, Liu Y, Mitchell BD, Morris AP, Mosley TH, Rotter JI, Shuldiner AR, Towne B, Völzke H, Wallaschofski H, Wilson JG, Allison M, Lindgren CM, Goessling W, Cupples LA, Steinhauser ML, Fox CS. Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat Genet. 2017 01; 49(1):125-130. PMID: 27918534.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  15. Kumar S, Rajagopalan S, Sarkar P, Dorward DW, Peterson ME, Liao HS, Guillermier C, Steinhauser ML, Vogel SS, Long EO. Zinc-Induced Polymerization of Killer-Cell Ig-like Receptor into Filaments Promotes Its Inhibitory Function at Cytotoxic Immunological Synapses. Mol Cell. 2016 Apr 07; 62(1):21-33. PMID: 27058785.
    Citations: 3     Fields:    Translation:HumansCells
  16. Hosios AM, Hecht VC, Danai LV, Johnson MO, Rathmell JC, Steinhauser ML, Manalis SR, Vander Heiden MG. Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev Cell. 2016 Mar 07; 36(5):540-9. PMID: 26954548.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  17. Fazeli PK, Lun M, Kim SM, Bredella MA, Wright S, Zhang Y, Lee H, Catana C, Klibanski A, Patwari P, Steinhauser ML. FGF21 and the late adaptive response to starvation in humans. J Clin Invest. 2015 Nov 03; 125(12):4601-11. PMID: 26529252.
    Citations: 18     Fields:    Translation:HumansAnimals
  18. Kim SM, Lun M, Wang M, Senyo SE, Guillermier C, Patwari P, Steinhauser ML. Loss of white adipose hyperplastic potential is associated with enhanced susceptibility to insulin resistance. Cell Metab. 2014 Dec 02; 20(6):1049-58. PMID: 25456741.
    Citations: 34     Fields:    Translation:AnimalsCells
  19. Enikolopov G, Guillermier C, Wang M, Trakimas L, Steinhauser M, Lechene C. Brain stem cell division and maintenance studied using multi-isotope imaging mass spectrometry (MIMS). Surf Interface Anal. 2014 Nov 01; 46(Suppl 1):140-143. PMID: 26379335.
  20. Steinhauser ML, Guillermier C, Wang M, Lechene CP. Quantifying cell division with deuterated water and multi-isotope imaging mass spectrometry (MIMS). Surf Interface Anal. 2014 Nov 01; 46(Suppl 1):161-164. PMID: 26379340.
    Citations: 1     
  21. Steinhauser ML, Guillermier C, Wang M, Lechene CP. Approaches to increasing analytical throughput of human samples with multi-isotope imaging mass spectrometry. Surf Interface Anal. 2014 Nov 01; 46(Suppl 1):165-168. PMID: 26379341.
    Citations: 1     
  22. Guillermier C, Steinhauser ML, Lechene CP. Quasi-simultaneous acquisition of nine secondary ions with seven detectors on NanoSIMS50L: application to biological samples. Surf Interface Anal. 2014 Nov; 46(Suppl 1):150-153. PMID: 28649151.
    Citations: 1     
  23. Jay SM, Murthy AC, Hawkins JF, Wortzel JR, Steinhauser ML, Alvarez LM, Gannon J, Macrae CA, Griffith LG, Lee RT. An engineered bivalent neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation. 2013 Jul 09; 128(2):152-61. PMID: 23757312.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  24. Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013 May 09; 153(4):828-39. PMID: 23663781.
    Citations: 190     Fields:    Translation:HumansAnimalsCells
  25. Steinhauser ML, Lechene CP. Quantitative imaging of subcellular metabolism with stable isotopes and multi-isotope imaging mass spectrometry. Semin Cell Dev Biol. 2013 Aug-Sep; 24(8-9):661-7. PMID: 23660233.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  26. Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, Abo R, Tabebordbar M, Lee RT, Burge CB, Boyer LA. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell. 2013 Jan 31; 152(3):570-83. PMID: 23352431.
    Citations: 248     Fields:    Translation:HumansAnimalsCells
  27. Steinhauser ML, Lee RT. Pericyte progenitors at the crossroads between fibrosis and regeneration. Circ Res. 2013 Jan 18; 112(2):230-2. PMID: 23329790.
    Citations: 4     Fields:    
  28. Senyo SE, Steinhauser ML, Pizzimenti CL, Yang VK, Cai L, Wang M, Wu TD, Guerquin-Kern JL, Lechene CP, Lee RT. Mammalian heart renewal by pre-existing cardiomyocytes. Nature. 2013 Jan 17; 493(7432):433-6. PMID: 23222518.
    Citations: 322     Fields:    Translation:AnimalsCells
  29. Steinhauser ML, Bailey AP, Senyo SE, Guillermier C, Perlstein TS, Gould AP, Lee RT, Lechene CP. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Nature. 2012 Jan 15; 481(7382):516-9. PMID: 22246326.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  30. Steinhauser ML, Lee RT. Regeneration of the heart. EMBO Mol Med. 2011 Dec; 3(12):701-12. PMID: 22095736.
    Citations: 41     Fields:    Translation:HumansCells
  31. Loffredo FS, Steinhauser ML, Gannon J, Lee RT. Bone marrow-derived cell therapy stimulates endogenous cardiomyocyte progenitors and promotes cardiac repair. Cell Stem Cell. 2011 Apr 08; 8(4):389-98. PMID: 21474103.
    Citations: 156     Fields:    Translation:AnimalsCells
  32. Amadi OC, Steinhauser ML, Nishi Y, Chung S, Kamm RD, McMahon AP, Lee RT. A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment. Biomed Microdevices. 2010 Dec; 12(6):1027-41. PMID: 20661647.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  33. Seki K, Sanada S, Kudinova AY, Steinhauser ML, Handa V, Gannon J, Lee RT. Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling. Circ Heart Fail. 2009 Nov; 2(6):684-91. PMID: 19919994.
    Citations: 80     Fields:    Translation:AnimalsCells
  34. Steinhauser ML, Lee RT. Cardiovascular regeneration: pushing and pulling on progenitors. Cell Stem Cell. 2009 Apr 03; 4(4):277-8. PMID: 19341614.
    Citations: 4     Fields:    Translation:Animals
  35. Steinhauser ML, Stone PH. Risk stratification and management of aortic stenosis with concomitant left ventricular dysfunction. Curr Treat Options Cardiovasc Med. 2007 Dec; 9(6):490-500. PMID: 18221601.
  36. Steinhauser ML, Hogaboam CM, Matsukawa A, Lukacs NW, Strieter RM, Kunkel SL. Chemokine C10 promotes disease resolution and survival in an experimental model of bacterial sepsis. Infect Immun. 2000 Nov; 68(11):6108-14. PMID: 11035713.
    Citations: 8     Fields:    Translation:Animals
  37. Bone-Larson CL, Hogaboam CM, Steinhauser ML, Oliveira SH, Lukacs NW, Strieter RM, Kunkel SL. Novel protective effects of stem cell factor in a murine model of acute septic peritonitis. Dependence on MCP-1. Am J Pathol. 2000 Oct; 157(4):1177-86. PMID: 11021822.
    Citations: 6     Fields:    Translation:AnimalsCells
  38. Hogaboam CM, Bone-Larson CL, Steinhauser ML, Matsukawa A, Gosling J, Boring L, Charo IF, Simpson KJ, Lukacs NW, Kunkel SL. Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C-C chemokine receptor 2. Am J Pathol. 2000 Apr; 156(4):1245-52. PMID: 10751350.
    Citations: 35     Fields:    Translation:Animals
  39. Hogaboam CM, Bone-Larson C, Matsukawa A, Steinhauser ML, Blease K, Lukacs NW, Kunkel SL. Therapeutic use of chemokines. Curr Pharm Des. 2000 Apr; 6(6):651-63. PMID: 10788602.
    Citations: 2     Fields:    Translation:HumansAnimals
  40. Hogaboam CM, Blease K, Mehrad B, Steinhauser ML, Standiford TJ, Kunkel SL, Lukacs NW. Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus. Am J Pathol. 2000 Feb; 156(2):723-32. PMID: 10666400.
    Citations: 55     Fields:    Translation:AnimalsCellsPHPublic Health
  41. Hogaboam CM, Bone-Larson CL, Steinhauser ML, Lukacs NW, Colletti LM, Simpson KJ, Strieter RM, Kunkel SL. Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines. FASEB J. 1999 Sep; 13(12):1565-74. PMID: 10463948.
    Citations: 32     Fields:    Translation:AnimalsCells
  42. Steinhauser ML, Kunkel SL, Hogaboam CM. New Frontiers in Cytokine Involvement during Experimental Sepsis. ILAR J. 1999 Sep; 40(4):142-150. PMID: 11406692.
    Citations: 1     Fields:    
  43. Steinhauser ML, Hogaboam CM, Lukacs NW, Strieter RM, Kunkel SL. Multiple roles for IL-12 in a model of acute septic peritonitis. J Immunol. 1999 May 01; 162(9):5437-43. PMID: 10228022.
    Citations: 22     Fields:    Translation:Animals
  44. Hogaboam CM, Simpson KJ, Chensue SW, Steinhauser ML, Lukacs NW, Gauldie J, Strieter RM, Kunkel SL. Macrophage inflammatory protein-2 gene therapy attenuates adenovirus- and acetaminophen-mediated hepatic injury. Gene Ther. 1999 Apr; 6(4):573-84. PMID: 10476217.
    Citations: 16     Fields:    Translation:AnimalsCells
  45. Steinhauser ML, Hogaboam CM, Kunkel SL, Lukacs NW, Strieter RM, Standiford TJ. IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense. J Immunol. 1999 Jan 01; 162(1):392-9. PMID: 9886412.
    Citations: 81     Fields:    Translation:AnimalsCells
  46. Hogaboam CM, Steinhauser ML, Chensue SW, Kunkel SL. Novel roles for chemokines and fibroblasts in interstitial fibrosis. Kidney Int. 1998 Dec; 54(6):2152-9. PMID: 9853282.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  47. Steinhauser ML, Kunkel SL, Hogaboam CM, Evanoff H, Strieter RM, Lukacs NW. Macrophage/fibroblast coculture induces macrophage inflammatory protein-1alpha production mediated by intercellular adhesion molecule-1 and oxygen radicals. J Leukoc Biol. 1998 Nov; 64(5):636-41. PMID: 9823769.
    Citations: 10     Fields:    Translation:AnimalsCells
  48. Hogaboam CM, Steinhauser ML, Schock H, Lukacs N, Strieter RM, Standiford T, Kunkel SL. Therapeutic effects of nitric oxide inhibition during experimental fecal peritonitis: role of interleukin-10 and monocyte chemoattractant protein 1. Infect Immun. 1998 Feb; 66(2):650-5. PMID: 9453622.
    Citations: 14     Fields:    Translation:Animals
  49. Hogaboam CM, Chensue SW, Steinhauser ML, Huffnagle GB, Lukacs NW, Strieter RM, Kunkel SL. Alteration of the cytokine phenotype in an experimental lung granuloma model by inhibiting nitric oxide. J Immunol. 1997 Dec 01; 159(11):5585-93. PMID: 9548500.
    Citations: 14     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.