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Gyorgy Frendl, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rhee Y, Palmer LJ, Okamoto K, Gemunden S, Hammouda K, Kemble SK, Lin MY, Lolans K, Fogg L, Guanaga D, Yokoe DS, Weinstein RA, Frendl G, Hayden MK. Differential Effects of Chlorhexidine Skin Cleansing Methods on Residual Chlorhexidine Skin Concentrations and Bacterial Recovery. Infect Control Hosp Epidemiol. 2018 Apr; 39(4):405-411. PMID: 29493475.
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  2. Mizuguchi KA, Huang CC, Shempp I, Wang J, Shekar P, Frendl G. Predicting kidney disease progression in patients with acute kidney injury after cardiac surgery. J Thorac Cardiovasc Surg. 2018 Jun; 155(6):2455-2463.e5. PMID: 29548590.
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  3. Elias KM, Fendler W, Stawiski K, Fiascone SJ, Vitonis AF, Berkowitz RS, Frendl G, Konstantinopoulos P, Crum CP, Kedzierska M, Cramer DW, Chowdhury D. Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer. Elife. 2017 10 31; 6. PMID: 29087294.
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  4. Shih YN, Chen YT, Chu H, Shih CJ, Ou SM, Hsu YT, Chen RC, Quraishi SA, Aisiku IP, Seethala RR, Frendl G, Hou PC. Association of pre-hospital theophylline use and mortality in chronic obstructive pulmonary disease patients with sepsis. Respir Med. 2017 04; 125:33-38. PMID: 28340860.
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  5. Fernandez-Bustamante A, Frendl G, Sprung J, Kor DJ, Subramaniam B, Martinez Ruiz R, Lee JW, Henderson WG, Moss A, Mehdiratta N, Colwell MM, Bartels K, Kolodzie K, Giquel J, Vidal Melo MF. Postoperative Pulmonary Complications, Early Mortality, and Hospital Stay Following Noncardiothoracic Surgery: A Multicenter Study by the Perioperative Research Network Investigators. JAMA Surg. 2017 Feb 01; 152(2):157-166. PMID: 27829093.
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  6. Seethala RR, Hou PC, Aisiku IP, Frendl G, Park PK, Mikkelsen ME, Chang SY, Gajic O, Sevransky J. Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients. Ann Intensive Care. 2017 Dec; 7(1):11. PMID: 28116595.
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  7. Shih YN, Chen YT, Shih CJ, Ou SM, Hsu YT, Chen RC, Aisiku IP, Seethala RR, Frendl G, Hou PC. Association of weekend effect with early mortality in severe sepsis patients over time. J Infect. 2017 04; 74(4):345-351. PMID: 28025161.
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  8. Frendl G. The Mystery of Delirium. Could Biomarkers of Endothelial Activation Reveal the Secrets? Crit Care Med. 2016 09; 44(9):1795-6. PMID: 27526004.
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  9. Edrich T, Stopfkuchen-Evans M, Scheiermann P, Heim M, Chan W, Stone MB, Dankl D, Aichner J, Hinzmann D, Song P, Szabo AL, Frendl G, Vlassakov K, Varelmann D. A Comparison of Web-Based with Traditional Classroom-Based Training of Lung Ultrasound for the Exclusion of Pneumothorax. Anesth Analg. 2016 07; 123(1):123-8. PMID: 27159073.
    View in: PubMed
  10. Pavkovic M, Robinson-Cohen C, Chua AS, Nicoara O, Cárdenas-González M, Bijol V, Ramachandran K, Hampson L, Pirmohamed M, Antoine DJ, Frendl G, Himmelfarb J, Waikar SS, Vaidya VS. Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423. Toxicol Sci. 2016 07; 152(1):205-13. PMID: 27122240; PMCID: PMC5009468 [Available on 07/01/17].
  11. Ng JM, Sugarbaker DJ, Bienfang DC, Richards WG, DaSilva MC, Frendl G, Hartigan PM. Perioperative Ischemic Optic Neuropathy Following Extrapleural Pneumonectomy. J Cardiothorac Vasc Anesth. 2016 Dec; 30(6):1645-1648. PMID: 27178100.
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  12. Elias KM, Kang S, Liu X, Horowitz NS, Berkowitz RS, Frendl G. Erratum to: Anesthetic Selection and Disease-Free Survival Following Optimal Primary Cytoreductive Surgery for Stage III Epithelial Ovarian Cancer. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:S1606-7. PMID: 25631066.
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  13. Elias KM, Kang S, Liu X, Horowitz NS, Berkowitz RS, Frendl G. Erratum to: Anesthetic Selection and Disease-Free Survival Following Optimal Primary Cytoreductive Surgery for Stage III Epithelial Ovarian Cancer. Ann Surg Oncol. 2015 Dec; 22 Suppl 3:S1611. PMID: 25821001.
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  14. Edrich T, Frendl G, Michaud G, Paschalidis ICh. Heparin requirements for full anticoagulation are higher for patients on dabigatran than for those on warfarin - a model-based study. Clin Pharmacol. 2015; 7:19-27. PMID: 25709508; PMCID: PMC4327399.
  15. Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Rawn JD, Frendl G, Waikar SS. Increased plasma catalytic iron in patients may mediate acute kidney injury and death following cardiac surgery. Kidney Int. 2015 May; 87(5):1046-54. PMID: 25565307.
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  16. Elias KM, Kang S, Liu X, Horowitz NS, Berkowitz RS, Frendl G. Anesthetic selection and disease-free survival following optimal primary cytoreductive surgery for stage III epithelial ovarian cancer. Ann Surg Oncol. 2015 Apr; 22(4):1341-8. PMID: 25287437.
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  17. Frendl G, Sodickson AC, Chung MK, Waldo AL, Gersh BJ, Tisdale JE, Calkins H, Aranki S, Kaneko T, Cassivi S, Smith SC, Darbar D, Wee JO, Waddell TK, Amar D, Adler D. 2014 AATS guidelines for the prevention and management of perioperative atrial fibrillation and flutter for thoracic surgical procedures. J Thorac Cardiovasc Surg. 2014 Sep; 148(3):e153-93. PMID: 25129609; PMCID: PMC4454633.
  18. Frendl G, Sodickson AC, Chung MK, Waldo AL, Gersh BJ, Tisdale JE, Calkins H, Aranki S, Kaneko T, Cassivi S, Smith SC, Darbar D, Wee JO, Waddell TK, Amar D, Adler D. 2014 AATS guidelines for the prevention and management of perioperative atrial fibrillation and flutter for thoracic surgical procedures. Executive summary. J Thorac Cardiovasc Surg. 2014 Sep; 148(3):772-91. PMID: 25129583.
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  19. Rahaghi FN, Lazea D, Dihya S, San José Estépar R, Bueno R, Sugarbaker D, Frendl G, Washko GR. Preoperative pulmonary vascular morphology and its relationship to postpneumonectomy hemodynamics. Acad Radiol. 2014 Jun; 21(6):704-10. PMID: 24809312; PMCID: PMC4266986.
  20. Oxman DA, Adams CD, Deluke G, Philbrook L, Ireland P, Mitani A, Panizales C, Frendl G, Rogers SO. Improving Antibiotic De-Escalation in Suspected Ventilator-Associated Pneumonia: An Observational Study With a Pharmacist-Driven Intervention. J Pharm Pract. 2015 Oct; 28(5):457-61. PMID: 24651641.
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  21. Williams M, Alban RF, Hardy JP, Oxman DA, Garcia ER, Hevelone N, Frendl G, Rogers SO. In-hospital fellow coverage reduces communication errors in the surgical intensive care unit. J Crit Care. 2014 Jun; 29(3):445-9. PMID: 24529985.
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  22. Edrich T, Seethala RR, Olenchock BA, Mizuguchi AK, Rivero JM, Beutler SS, Fox JA, Liu X, Frendl G. Providing initial transthoracic echocardiography training for anesthesiologists: simulator training is not inferior to live training. J Cardiothorac Vasc Anesth. 2014 Feb; 28(1):49-53. PMID: 24183827.
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  23. Frendl G. Benzodiazepines: revealing of the secrets of GABAA-mediated immunosuppression: GABAA subtype-specific benzodiazepines are the hope. Crit Care Med. 2013 Jul; 41(7):1807-8. PMID: 23774342.
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  24. Oxman DA, Issa NC, Marty FM, Patel A, Panizales CZ, Johnson NN, Licona JH, McKenna SS, Frendl G, Mentzer SJ, Jaklitsch MT, Bueno R, Colson Y, Swanson SJ, Sugarbaker DJ, Baden LR. Postoperative antibacterial prophylaxis for the prevention of infectious complications associated with tube thoracostomy in patients undergoing elective general thoracic surgery: a double-blind, placebo-controlled, randomized trial. JAMA Surg. 2013 May; 148(5):440-6. PMID: 23325435.
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  25. Edrich T, Frendl G. Simulation training for rare medications in the intensive care unit-a study with bivalirudin. Anaesth Intensive Care. 2013 Mar; 41(2):242-6. PMID: 23530791.
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  26. Elie-Turenne MC, Hou PC, Mitani A, Barry JM, Kao EY, Cohen JE, Frendl G, Gajic O, Gentile NT. Lung injury prediction score for the emergency department: first step towards prevention in patients at risk. Int J Emerg Med. 2012 Sep 03; 5(1):33. PMID: 22943391; PMCID: PMC3598475.
  27. Hoffmann D, Bijol V, Krishnamoorthy A, Gonzalez VR, Frendl G, Zhang Q, Goering PL, Brown RP, Waikar SS, Vaidya VS. Fibrinogen excretion in the urine and immunoreactivity in the kidney serves as a translational biomarker for acute kidney injury. Am J Pathol. 2012 Sep; 181(3):818-28. PMID: 22819533; PMCID: PMC3432430.
  28. Zhao H, Heard SO, Mullen MT, Crawford S, Goldberg RJ, Frendl G, Lilly CM. An evaluation of the diagnostic accuracy of the 1991 American College of Chest Physicians/Society of Critical Care Medicine and the 2001 Society of Critical Care Medicine/European Society of Intensive Care Medicine/American College of Chest Physicians/American Thoracic Society/Surgical Infection Society sepsis definition. Crit Care Med. 2012 Jun; 40(6):1700-6. PMID: 22610176.
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  29. Hou PC, Elie-Turenne MC, Mitani A, Barry JM, Kao EY, Cohen JE, Frendl G, Gajic O, Gentile NT. Towards prevention of acute lung injury: frequency and outcomes of emergency department patients at-risk - a multicenter cohort study. Int J Emerg Med. 2012 May 27; 5(1):22. PMID: 22632126; PMCID: PMC3598496.
  30. Ng SY, Sugarbaker DJ, Frendl G. Interatrial shunting after major thoracic surgery: a rare but clinically significant event. Ann Thorac Surg. 2012 May; 93(5):1647-51. PMID: 22541195.
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  31. Mizuguchi KA, Mitani A, Waikar SS, Ireland P, Panizales C, Deluke G, Sugarbaker DJ, Bonventre JV, Frendl G. Use of postoperative creatinine to predict sustained kidney injury in patients undergoing mesothelioma surgery. Clin J Am Soc Nephrol. 2012 Jul; 7(7):1071-8. PMID: 22537654; PMCID: PMC3386676.
  32. Edrich T, Frendl G, Rawn JD, Paschalidis Y. Modeling the effects of bivalirudin in cardiac surgical patients. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:120-3. PMID: 22254265.
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  33. Oxman DA, Chow JK, Frendl G, Hadley S, Hershkovitz S, Ireland P, McDermott LA, Tsai K, Marty FM, Kontoyiannis DP, Golan Y. Candidaemia associated with decreased in vitro fluconazole susceptibility: is Candida speciation predictive of the susceptibility pattern? J Antimicrob Chemother. 2010 Jul; 65(7):1460-5. PMID: 20430790.
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  34. Williams M, Hevelone N, Alban RF, Hardy JP, Oxman DA, Garcia E, Thorsen C, Frendl G, Rogers SO. Measuring communication in the surgical ICU: better communication equals better care. J Am Coll Surg. 2010 Jan; 210(1):17-22. PMID: 20123326.
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  35. Mizuguchi A, Frendl G. Multi-organ system failure. Segal S, Sikka P, Urman R, Vacanti C, editors. Essential Clinical Anesthesia. 2009.
  36. Oxman D, McKenna S, Frendl G. Nosocomial infections in essential clinical anesthesia. Segal S, Sikka P, Urman R, Vacanti C, editors. Essential Clinical Anesthesia. 2009.
  37. Williams M, Frendl G. total parenteral nutrition. Segal S, Sikka P, Urman R, Vacanti C, editors. Essential Clinical Anesthesia. 2009.
  38. Melanson SE, Szymanski T, Rogers SO, Jarolim P, Frendl G, Rawn JD, Cooper Z, Ferrigno M. Utilization of arterial blood gas measurements in a large tertiary care hospital. Am J Clin Pathol. 2007 Apr; 127(4):604-9. PMID: 17369137.
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  39. Romics L, Frendl G, Szabó G. [Cellular and molecular changes of the liver in sepsis and in systemic inflammatory response syndrome (SIRS)]. Orv Hetil. 2003 Mar 16; 144(11):499-506. PMID: 12731336.
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  40. Szabo G, Romics L, Frendl G. Liver in sepsis and systemic inflammatory response syndrome. Clin Liver Dis. 2002 Nov; 6(4):1045-66, x. PMID: 12516206.
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  41. Szabo G, Romics L, Frendl G. Liver in sepsis and systemic inflammatory response syndrome. Bonkovsky H, editor. Clinics in liver disease, hepatic manifestations of systemic diseases. 2002; 6:1045-1066.
  42. Colgan SP, Parkos CA, McGuirk D, Brady HR, Papayianni AA, Frendl G, Madara JL. Receptors involved in carbohydrate binding modulate intestinal epithelial-neutrophil interactions. J Biol Chem. 1995 May 05; 270(18):10531-9. PMID: 7537733.
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  43. Stahl GL, Reenstra WR, Frendl G. Complement-mediated loss of endothelium-dependent relaxation of porcine coronary arteries. Role of the terminal membrane attack complex. Circ Res. 1995 Apr; 76(4):575-83. PMID: 7534659.
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  44. Frendl G, Guan RJ, Reensra W. Antisense oligonucleotide blocking of RAF-1 prevents both LPS-induced activation and nuclear translocation of MAP kinases in macrophages. J Leuk Biol. 1995; Suppl:28.
  45. Guan RJ, Reenstra W, Frendl G. RAF-1 is essential for both the LPS-induced activation of MAP kinases in macrophages and for their translocation to the nucleus. FASEB J. 1995; 9(4):A779.
  46. Frendl G, Reenstra W, Xanthopoulos L, Kendig L, Rollins B. Macrophages are key elements of tissue destruction in a novel model of experimental colitis. FASEB J. 1995; 9(4):A1035.
  47. Frendl G, Guan R. The mitogen-activated protein kinase (MAP-kinase) is a common element of multiple macrophage activation pathways: Activation of MAP kinase by LPS, GM-CSF, and other macrophage activating factors. Masihi KN, editor. Immunotherapy of infections. 1994; 423-455.
  48. Frendl G, Nicholasen S, Murphy JR, LaMont JT. A novel experimental colitis model: The role of iL-2 receptor positive mucosal cells. J Leuk Biol (Suppl). 1994; 56:A22.
  49. Frendl G, Guan R, Szilvasi A, Hirsch R. MAP kinases are involved in mediating signaling from IFN, IL-3 and GM-CSF receptors in macrophages. FASEB J. 1994; 8:A744.
  50. Hirsch R, Nicholasen S, Murphy JR, LaMont JT, Frendl G. the role of IL-2 receptor positive cells in experimental colitis. FASEB J. 1994; 8:A1010.
  51. Jiang Y, Beller DI, Frendl G, Graves DT. Monocyte chemoattractant protein-1 regulates adhesion molecule expression and cytokine production in human monocytes. J Immunol. 1992 Apr 15; 148(8):2423-8. PMID: 1348518.
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  52. Frendl G. Interleukin 3: from colony-stimulating factor to pluripotent immunoregulatory cytokine. Int J Immunopharmacol. 1992 Apr; 14(3):421-30. PMID: 1618595.
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  53. Frendl G, Fenton MJ, Beller DI. IL-3 regulates macrophage IL-1, IL-6 and TNF expression at the level of transcription and post-transcriptional regulation. 8th Internatl Cong Immunol., Budapest, Hungary. 1992; 148.
  54. Guan R, Frendl G, Beller DI. Lipopolysaccharide activated multiple protein kinases n macrophages. Molec Biol Cell. Suppl. 1992; 3:337a.
  55. Frendl G, Guan R, Beller DI. IFN activates the MAP kinase in murine macropahges. Molec Biol Cell Suppl. 1992; 3:148a.
  56. Frendl G. Interleukin-3: From colony-stimulting factor to pluripotent immunoregulatory cytokine. Int J Immunopharmac. 1992; 14:421-430.
  57. Donnelly RP, Levine J, Hartwell DQ, Frendl G, Fenton MJ, Beller DI. Aberrant regulation of IL-1 expression in macrophages from young autoimmune-prone mice. J Immunol. 1990 Nov 15; 145(10):3231-9. PMID: 2230116.
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  58. Frendl G, Fenton MJ, Beller DI. Regulation of macrophage activation by IL-3. II. IL-3 and lipopolysaccharide act synergistically in the regulation of IL-1 expression. J Immunol. 1990 May 01; 144(9):3400-10. PMID: 2109777.
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  59. Frendl G, Beller DI. Regulation of macrophage activation by IL-3. I. IL-3 functions as a macrophage-activating factor with unique properties, inducing Ia and lymphocyte function-associated antigen-1 but not cytotoxicity. J Immunol. 1990 May 01; 144(9):3392-9. PMID: 2158509.
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  60. Bodolay E, Lukács K, Frendl G, Szabó G, Arató G, Szegedi G. Polymorphonuclear functions in patients with mixed connective tissue disease. Allergol Immunopathol (Madr). 1989 Jul-Aug; 17(4):205-7. PMID: 2530862.
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  61. Bodolay E, Lukács K, Szabó G, Frendl G, Ben T, Szegedi G. Monocyte functions in patients with mixed connective tissue disease. Allergol Immunopathol (Madr). 1989 Jan-Feb; 17(1):39-43. PMID: 2526572.
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  62. Frendl G, Beller DI. Ia inducing activity of macrophage origin. FASEB J. 1988; 2:A685.
  63. Frendl G, et al. Stimulation of neutrophil functions by lymphokines adn synthetic stimulators. Immunobiologics & their application. Budapest, Hungary. 1985; 21.
  64. Szabo G, Lukacs G, Frendl G, et al. Stimulating effect of tetrapeptide tuftsin in autoimmune and malignant diseases. Immunobiologics & Their Application. Budapest, Hungary. 1985; 27.
  65. Lukács K, Kávai M, Berényi E, Frendl G, Schröder I, Szegedi G. Effect of dialysable leukocyte extract on the mononuclear leukocytes in Hodgkin's disease. Haematologia (Budap). 1985; 18(2):105-13. PMID: 3161810.
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  66. Lukács K, Frendl G, Berényi E, Kávai M, Szabó G, Szegedi G. Monocyte chemotaxis and effect of levamisole in Hodgkin's disease. Acta Med Acad Sci Hung. 1980; 37(2):145-50. PMID: 7457021.
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