Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileDara Sue Manoach, Ph.D.

TitleProfessor of Psychology in the Department of Psychiatry
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Psychiatric Neuroimaging, Room 2608
149 13th Street
Charlestown MA 02129
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01MH107579     (KESHAVAN, MATCHERI S.)Sep 7, 2015 - May 31, 2020
Sleep spindles in early course schizophrenia and first-degree relatives
Role: Co-Principal Investigator

K24MH099421     (MANOACH, DARA S)Dec 1, 2012 - Nov 30, 2017
Mentoring and Research on Cognitive Deficits in Schizophrenia
Role: Principal Investigator

R01MH092638     (MANOACH, DARA S)Jul 1, 2012 - Mar 31, 2015
Sleep-dependent Memory Processing in Schizophrenia
Role: Principal Investigator

R01MH067720     (MANOACH, DARA S)Apr 1, 2003 - Nov 30, 2012
Spatiotemporal dynamics of contextual processing in schizophrenia
Role: Principal Investigator

K23MH001829     (MANOACH, DARA S)Dec 10, 1999 - May 31, 2005
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Roffman JL, Petruzzi LJ, Tanner AS, Brown HE, Eryilmaz H, Ho NF, Giegold M, Silverstein NJ, Bottiglieri T, Manoach DS, Smoller JW, Henderson DC, Goff DC. Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial. Mol Psychiatry. 2017 Mar 14. PMID: 28289280.
    View in: PubMed
  2. Lee PH, Baker JT, Holmes AJ, Jahanshad N, Ge T, Jung JY, Cruz Y, Manoach DS, Hibar DP, Faskowitz J, McMahon KL, de Zubicaray GI, Martin NH, Wright MJ, Öngür D, Buckner R, Roffman J, Thompson PM, Smoller JW. Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia. Mol Psychiatry. 2017 Feb 21. PMID: 28220043.
    View in: PubMed
  3. Demanuele C, Bartsch U, Baran B, Khan S, Vangel MG, Cox R, Hämäläinen M, Jones MW, Stickgold R, Manoach DS. Coordination of Slow Waves With Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia. Sleep. 2017 Jan 01; 40(1). PMID: 28364465.
    View in: PubMed
  4. Baran B, Karahanoglu FI, Agam Y, Mantonakis L, Manoach DS. Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia. Neuroimage Clin. 2016; 12:887-893. PMID: 27872811.
    View in: PubMed
  5. Lee PH, Baker JT, Holmes AJ, Jahanshad N, Ge T, Jung JY, Cruz Y, Manoach DS, Hibar DP, Faskowitz J, McMahon KL, de Zubicaray GI, Martin NH, Wright MJ, Öngür D, Buckner R, Roffman J, Thompson PM, Smoller JW. Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia. Mol Psychiatry. 2016 Dec; 21(12):1680-1689. PMID: 27725656.
    View in: PubMed
  6. Demanuele C, Bartsch U, Baran B, Khan S, Vangel MG, Cox R, Hämäläinen M, Jones MW, Stickgold R, Manoach DS. Coordination of Slow Waves with Sleep Spindles Predicts Sleep-Dependent Memory Consolidation in Schizophrenia. Sleep. 2016 Sep 09. PMID: 27634797.
    View in: PubMed
  7. Roffman JL, Tanner AS, Eryilmaz H, Rodriguez-Thompson A, Silverstein NJ, Ho NF, Nitenson AZ, Chonde DB, Greve DN, Abi-Dargham A, Buckner RL, Manoach DS, Rosen BR, Hooker JM, Catana C. Dopamine D1 signaling organizes network dynamics underlying working memory. Sci Adv. 2016 Jun; 2(6):e1501672. PMID: 27386561; PMCID: PMC4928887.
  8. Hwang K, Ghuman AS, Manoach DS, Jones SR, Luna B. Frontal preparatory neural oscillations associated with cognitive control: A developmental study comparing young adults and adolescents. Neuroimage. 2016 Aug 01; 136:139-48. PMID: 27173759; PMCID: PMC4914451 [Available on 08/01/17].
  9. Manoach DS, Stickgold R. Sleep: Keeping One Eye Open. Curr Biol. 2016 May 09; 26(9):R360-1. PMID: 27166693.
    View in: PubMed
  10. Eryilmaz H, Tanner AS, Ho NF, Nitenson AZ, Silverstein NJ, Petruzzi LJ, Goff DC, Manoach DS, Roffman JL. Disrupted Working Memory Circuitry in Schizophrenia: Disentangling fMRI Markers of Core Pathology vs Other Aspects of Impaired Performance. Neuropsychopharmacology. 2016 Aug; 41(9):2411-20. PMID: 27103065; PMCID: PMC4946071 [Available on 08/01/17].
  11. Gregory MD, Robertson EM, Manoach DS, Stickgold R. Thinking About a Task Is Associated with Increased Connectivity in Regions Activated by Task Performance. Brain Connect. 2016 Mar; 6(2):164-8. PMID: 26650337; PMCID: PMC4779977 [Available on 03/01/17].
  12. Yeo RA, Ryman SG, van den Heuvel MP, de Reus MA, Jung RE, Pommy J, Mayer AR, Ehrlich S, Schulz SC, Morrow EM, Manoach D, Ho BC, Sponheim SR, Calhoun VD. Graph Metrics of Structural Brain Networks in Individuals with Schizophrenia and Healthy Controls: Group Differences, Relationships with Intelligence, and Genetics. J Int Neuropsychol Soc. 2016 Feb; 22(2):240-9. PMID: 26888620.
    View in: PubMed
  13. Jääskeläinen IP, Halme HL, Agam Y, Glerean E, Lahnakoski JM, Sams M, Tapani K, Ahveninen J, Manoach DS. Neural mechanisms supporting evaluation of others' errors in real-life like conditions. Sci Rep. 2016 Jan 05; 6:18714. PMID: 26729348; PMCID: PMC4700495.
  14. Maski K, Holbrook H, Manoach D, Hanson E, Kapur K, Stickgold R. Sleep Dependent Memory Consolidation in Children with Autism Spectrum Disorder. Sleep. 2015 Dec 01; 38(12):1955-63. PMID: 26194566; PMCID: PMC4667378.
  15. Shaffer JJ, Peterson MJ, McMahon MA, Bizzell J, Calhoun V, van Erp TG, Ford JM, Lauriello J, Lim KO, Manoach DS, McEwen SC, Mathalon DH, O'Leary D, Potkin SG, Preda A, Turner J, Voyvodic J, Wible CG, Belger A. Neural Correlates of Schizophrenia Negative Symptoms: Distinct Subtypes Impact Dissociable Brain Circuits. Mol Neuropsychiatry. 2015 Dec; 1(4):191-200. PMID: 27606313; PMCID: PMC4996000 [Available on 12/01/16].
  16. Manoach DS, Pan JQ, Purcell SM, Stickgold R. Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition? Biol Psychiatry. 2016 Oct 15; 80(8):599-608. PMID: 26602589; PMCID: PMC4833702 [Available on 10/15/17].
  17. Manoach DS, Stickgold R. Sleep, memory and schizophrenia. Sleep Med. 2015 May; 16(5):553-4. PMID: 25747334.
    View in: PubMed
  18. Manoach DS, Demanuele C, Wamsley EJ, Vangel M, Montrose DM, Miewald J, Kupfer D, Buysse D, Stickgold R, Keshavan MS. Sleep spindle deficits in antipsychotic-naïve early course schizophrenia and in non-psychotic first-degree relatives. Front Hum Neurosci. 2014; 8:762. PMID: 25339881; PMCID: PMC4188028.
  19. Gregory MD, Agam Y, Selvadurai C, Nagy A, Vangel M, Tucker M, Robertson EM, Stickgold R, Manoach DS. Resting state connectivity immediately following learning correlates with subsequent sleep-dependent enhancement of motor task performance. Neuroimage. 2014 Nov 15; 102 Pt 2:666-73. PMID: 25173415; PMCID: PMC4252600.
  20. Hwang K, Ghuman AS, Manoach DS, Jones SR, Luna B. Cortical neurodynamics of inhibitory control. J Neurosci. 2014 Jul 16; 34(29):9551-61. PMID: 25031398; PMCID: PMC4099539.
  21. Agam Y, Vangel M, Roffman JL, Gallagher PJ, Chaponis J, Haddad S, Goff DC, Greenberg JL, Wilhelm S, Smoller JW, Manoach DS. Dissociable genetic contributions to error processing: a multimodal neuroimaging study. PLoS One. 2014; 9(7):e101784. PMID: 25010186; PMCID: PMC4092014.
  22. Agam Y, Greenberg JL, Isom M, Falkenstein MJ, Jenike E, Wilhelm S, Manoach DS. Aberrant error processing in relation to symptom severity in obsessive-compulsive disorder: A multimodal neuroimaging study. Neuroimage Clin. 2014; 5:141-51. PMID: 25057466; PMCID: PMC4096999.
  23. Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, Toro R, Jahanshad N, Schumann G, Franke B, Wright MJ, Martin NG, Agartz I, Alda M, Alhusaini S, Almasy L, Almeida J, Alpert K, Andreasen NC, Andreassen OA, Apostolova LG, Appel K, Armstrong NJ, Aribisala B, Bastin ME, Bauer M, Bearden CE, Bergmann O, Binder EB, Blangero J, Bockholt HJ, Bøen E, Bois C, Boomsma DI, Booth T, Bowman IJ, Bralten J, Brouwer RM, Brunner HG, Brohawn DG, Buckner RL, Buitelaar J, Bulayeva K, Bustillo JR, Calhoun VD, Cannon DM, Cantor RM, Carless MA, Caseras X, Cavalleri GL, Chakravarty MM, Chang KD, Ching CR, Christoforou A, Cichon S, Clark VP, Conrod P, Coppola G, Crespo-Facorro B, Curran JE, Czisch M, Deary IJ, de Geus EJ, den Braber A, Delvecchio G, Depondt C, de Haan L, de Zubicaray GI, Dima D, Dimitrova R, Djurovic S, Dong H, Donohoe G, Duggirala R, Dyer TD, Ehrlich S, Ekman CJ, Elvsåshagen T, Emsell L, Erk S, Espeseth T, Fagerness J, Fears S, Fedko I, Fernández G, Fisher SE, Foroud T, Fox PT, Francks C, Frangou S, Frey EM, Frodl T, Frouin V, Garavan H, Giddaluru S, Glahn DC, Godlewska B, Goldstein RZ, Gollub RL, Grabe HJ, Grimm O, Gruber O, Guadalupe T, Gur RE, Gur RC, Göring HH, Hagenaars S, Hajek T, Hall GB, Hall J, Hardy J, Hartman CA, Hass J, Hatton SN, Haukvik UK, Hegenscheid K, Heinz A, Hickie IB, Ho BC, Hoehn D, Hoekstra PJ, Hollinshead M, Holmes AJ, Homuth G, Hoogman M, Hong LE, Hosten N, Hottenga JJ, Hulshoff Pol HE, Hwang KS, Jack CR, Jenkinson M, Johnston C, Jönsson EG, Kahn RS, Kasperaviciute D, Kelly S, Kim S, Kochunov P, Koenders L, Krämer B, Kwok JB, Lagopoulos J, Laje G, Landen M, Landman BA, Lauriello J, Lawrie SM, Lee PH, Le Hellard S, Lemaître H, Leonardo CD, Li CS, Liberg B, Liewald DC, Liu X, Lopez LM, Loth E, Lourdusamy A, Luciano M, Macciardi F, Machielsen MW, Macqueen GM, Malt UF, Mandl R, Manoach DS, Martinot JL, Matarin M, Mather KA, Mattheisen M, Mattingsdal M, Meyer-Lindenberg A, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Meisenzahl E, Melle I, Milaneschi Y, Mohnke S, Montgomery GW, Morris DW, Moses EK, Mueller BA, Muñoz Maniega S, Mühleisen TW, Müller-Myhsok B, Mwangi B, Nauck M, Nho K, Nichols TE, Nilsson LG, Nugent AC, Nyberg L, Olvera RL, Oosterlaan J, Ophoff RA, Pandolfo M, Papalampropoulou-Tsiridou M, Papmeyer M, Paus T, Pausova Z, Pearlson GD, Penninx BW, Peterson CP, Pfennig A, Phillips M, Pike GB, Poline JB, Potkin SG, Pütz B, Ramasamy A, Rasmussen J, Rietschel M, Rijpkema M, Risacher SL, Roffman JL, Roiz-Santiañez R, Romanczuk-Seiferth N, Rose EJ, Royle NA, Rujescu D, Ryten M, Sachdev PS, Salami A, Satterthwaite TD, Savitz J, Saykin AJ, Scanlon C, Schmaal L, Schnack HG, Schork AJ, Schulz SC, Schür R, Seidman L, Shen L, Shoemaker JM, Simmons A, Sisodiya SM, Smith C, Smoller JW, Soares JC, Sponheim SR, Sprooten E, Starr JM, Steen VM, Strakowski S, Strike L, Sussmann J, Sämann PG, Teumer A, Toga AW, Tordesillas-Gutierrez D, Trabzuni D, Trost S, Turner J, Van den Heuvel M, van der Wee NJ, van Eijk K, van Erp TG, van Haren NE, van 't Ent D, van Tol MJ, Valdés Hernández MC, Veltman DJ, Versace A, Völzke H, Walker R, Walter H, Wang L, Wardlaw JM, Weale ME, Weiner MW, Wen W, Westlye LT, Whalley HC, Whelan CD, White T, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Zilles D, Zwiers MP, Thalamuthu A, Schofield PR, Freimer NB, Lawrence NS, Drevets W. The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav. 2014 Jun; 8(2):153-82. PMID: 24399358; PMCID: PMC4008818.
  24. Walton E, Geisler D, Hass J, Liu J, Turner J, Yendiki A, Smolka MN, Ho BC, Manoach DS, Gollub RL, Roessner V, Calhoun VD, Ehrlich S. The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function. PLoS One. 2013; 8(10):e76815. PMID: 24098564; PMCID: PMC3788740.
  25. Agam Y, Carey C, Barton JJ, Dyckman KA, Lee AK, Vangel M, Manoach DS. Network dynamics underlying speed-accuracy trade-offs in response to errors. PLoS One. 2013; 8(9):e73692. PMID: 24069223; PMCID: PMC3772006.
  26. Wamsley EJ, Shinn AK, Tucker MA, Ono KE, McKinley SK, Ely AV, Goff DC, Stickgold R, Manoach DS. The effects of eszopiclone on sleep spindles and memory consolidation in schizophrenia: a randomized placebo-controlled trial. Sleep. 2013 Sep 01; 36(9):1369-76. PMID: 23997371; PMCID: PMC3738047.
  27. Peeva MG, Tourville JA, Agam Y, Holland B, Manoach DS, Guenther FH. White matter impairment in the speech network of individuals with autism spectrum disorder. Neuroimage Clin. 2013; 3:234-41. PMID: 24273708; PMCID: PMC3815014.
  28. Manoach DS, Agam Y. Neural markers of errors as endophenotypes in neuropsychiatric disorders. Front Hum Neurosci. 2013; 7:350. PMID: 23882201; PMCID: PMC3714549.
  29. Gollub RL, Shoemaker JM, King MD, White T, Ehrlich S, Sponheim SR, Clark VP, Turner JA, Mueller BA, Magnotta V, O'Leary D, Ho BC, Brauns S, Manoach DS, Seidman L, Bustillo JR, Lauriello J, Bockholt J, Lim KO, Rosen BR, Schulz SC, Calhoun VD, Andreasen NC. The MCIC collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of schizophrenia. Neuroinformatics. 2013 Jul; 11(3):367-88. PMID: 23760817; PMCID: PMC3727653.
  30. Jiang X, Bollich A, Cox P, Hyder E, James J, Gowani SA, Hadjikhani N, Blanz V, Manoach DS, Barton JJ, Gaillard WD, Riesenhuber M. A quantitative link between face discrimination deficits and neuronal selectivity for faces in autism. Neuroimage Clin. 2013; 2:320-31. PMID: 24179786; PMCID: PMC3777682.
  31. Manoach DS, Lee AK, Hämäläinen MS, Dyckman KA, Friedman JS, Vangel M, Goff DC, Barton JJ. Anomalous use of context during task preparation in schizophrenia: a magnetoencephalography study. Biol Psychiatry. 2013 May 15; 73(10):967-75. PMID: 23380717; PMCID: PMC3641151.
  32. van den Bosch GE, El Marroun H, Schmidt MN, Tibboel D, Manoach DS, Calhoun VD, White TJ. Brain connectivity during verbal working memory in children and adolescents. Hum Brain Mapp. 2014 Feb; 35(2):698-711. PMID: 23233279; PMCID: PMC4435694.
  33. Woodward TS, Feredoes E, Metzak PD, Takane Y, Manoach DS. Epoch-specific functional networks involved in working memory. Neuroimage. 2013 Jan 15; 65:529-39. PMID: 23041527.
    View in: PubMed
  34. White T, Ehrlich S, Ho BC, Manoach DS, Caprihan A, Schulz SC, Andreasen NC, Gollub RL, Calhoun VD, Magnotta VA. Spatial characteristics of white matter abnormalities in schizophrenia. Schizophr Bull. 2013 Sep; 39(5):1077-86. PMID: 22987296; PMCID: PMC3756779.
  35. He H, Sui J, Yu Q, Turner JA, Ho BC, Sponheim SR, Manoach DS, Clark VP, Calhoun VD. Altered small-world brain networks in schizophrenia patients during working memory performance. PLoS One. 2012; 7(6):e38195. PMID: 22701611; PMCID: PMC3368895.
  36. Kenet T, Orekhova EV, Bharadwaj H, Shetty NR, Israeli E, Lee AK, Agam Y, Elam M, Joseph RM, Hämäläinen MS, Manoach DS. Disconnectivity of the cortical ocular motor control network in autism spectrum disorders. Neuroimage. 2012 Jul 16; 61(4):1226-34. PMID: 22433660; PMCID: PMC3376722.
  37. Cullen KR, Wallace S, Magnotta VA, Bockholt J, Ehrlich S, Gollub RL, Manoach DS, Ho BC, Clark VP, Lauriello J, Bustillo JR, Schulz SC, Andreasen NC, Calhoun VD, Lim KO, White T. Cigarette smoking and white matter microstructure in schizophrenia. Psychiatry Res. 2012 Feb 28; 201(2):152-8. PMID: 22386966; PMCID: PMC3319200.
  38. Walton E, Turner J, Gollub RL, Manoach DS, Yendiki A, Ho BC, Sponheim SR, Calhoun VD, Ehrlich S. Cumulative genetic risk and prefrontal activity in patients with schizophrenia. Schizophr Bull. 2013 May; 39(3):703-11. PMID: 22267534; PMCID: PMC3627773.
  39. Barch DM, Moore H, Nee DE, Manoach DS, Luck SJ. CNTRICS imaging biomarkers selection: Working memory. Schizophr Bull. 2012 Jan; 38(1):43-52. PMID: 22080498; PMCID: PMC3245596.
  40. Agam Y, Hämäläinen MS, Lee AK, Dyckman KA, Friedman JS, Isom M, Makris N, Manoach DS. Multimodal neuroimaging dissociates hemodynamic and electrophysiological correlates of error processing. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17556-61. PMID: 21969565; PMCID: PMC3198335.
  41. Wamsley EJ, Tucker MA, Shinn AK, Ono KE, McKinley SK, Ely AV, Goff DC, Stickgold R, Manoach DS. Reduced sleep spindles and spindle coherence in schizophrenia: mechanisms of impaired memory consolidation? Biol Psychiatry. 2012 Jan 15; 71(2):154-61. PMID: 21967958; PMCID: PMC3561714.
  42. Roffman JL, Nitenson AZ, Agam Y, Isom M, Friedman JS, Dyckman KA, Brohawn DG, Smoller JW, Goff DC, Manoach DS. A hypomethylating variant of MTHFR, 677C>T, blunts the neural response to errors in patients with schizophrenia and healthy individuals. PLoS One. 2011; 6(9):e25253. PMID: 21980405; PMCID: PMC3182200.
  43. Dyckman KA, Lee AK, Agam Y, Vangel M, Goff DC, Barton JJ, Manoach DS. Abnormally persistent fMRI activation during antisaccades in schizophrenia: a neural correlate of perseveration? Schizophr Res. 2011 Oct; 132(1):62-8. PMID: 21831602; PMCID: PMC3172368.
  44. Ross M, Lanyon LJ, Viswanathan J, Manoach DS, Barton JJ. Human prosaccades and antisaccades under risk: effects of penalties and rewards on visual selection and the value of actions. Neuroscience. 2011 Nov 24; 196:168-77. PMID: 21846493.
    View in: PubMed
  45. Ehrlich S, Yendiki A, Greve DN, Manoach DS, Ho BC, White T, Schulz SC, Goff DC, Gollub RL, Holt DJ. Striatal function in relation to negative symptoms in schizophrenia. Psychol Med. 2012 Feb; 42(2):267-82. PMID: 21733291.
    View in: PubMed
  46. Roffman JL, Brohawn DG, Friedman JS, Dyckman KA, Thakkar KN, Agam Y, Vangel MG, Goff DC, Manoach DS. MTHFR 677C>T effects on anterior cingulate structure and function during response monitoring in schizophrenia: a preliminary study. Brain Imaging Behav. 2011 Mar; 5(1):65-75. PMID: 21190096; PMCID: PMC4229496.
  47. Kim DI, Sui J, Rachakonda S, White T, Manoach DS, Clark VP, Ho BC, Schulz SC, Calhoun VD. Identification of imaging biomarkers in schizophrenia: a coefficient-constrained independent component analysis of the mind multi-site schizophrenia study. Neuroinformatics. 2010 Dec; 8(4):213-29. PMID: 20607449; PMCID: PMC3690332.
  48. Abegg M, Manoach DS, Barton JJ. Knowing the future: partial foreknowledge effects on the programming of prosaccades and antisaccades. Vision Res. 2011 Jan; 51(1):215-21. PMID: 21093470.
    View in: PubMed
  49. Lee AK, Hämäläinen MS, Dyckman KA, Barton JJ, Manoach DS. Saccadic preparation in the frontal eye field is modulated by distinct trial history effects as revealed by magnetoencephalography. Cereb Cortex. 2011 Feb; 21(2):245-53. PMID: 20522539; PMCID: PMC3020577.
  50. Yendiki A, Greve DN, Wallace S, Vangel M, Bockholt J, Mueller BA, Magnotta V, Andreasen N, Manoach DS, Gollub RL. Multi-site characterization of an fMRI working memory paradigm: reliability of activation indices. Neuroimage. 2010 Oct 15; 53(1):119-31. PMID: 20451631; PMCID: PMC3810293.
  51. Agam Y, Joseph RM, Barton JJ, Manoach DS. Reduced cognitive control of response inhibition by the anterior cingulate cortex in autism spectrum disorders. Neuroimage. 2010 Aug 01; 52(1):336-47. PMID: 20394829; PMCID: PMC2883672.
  52. Tu P, Buckner RL, Zollei L, Dyckman KA, Goff DC, Manoach DS. Reduced functional connectivity in a right-hemisphere network for volitional ocular motor control in schizophrenia. Brain. 2010 Feb; 133(Pt 2):625-37. PMID: 20159769; PMCID: PMC2858012.
  53. Kim MA, Tura E, Potkin SG, Fallon JH, Manoach DS, Calhoun VD, Turner JA. Working memory circuitry in schizophrenia shows widespread cortical inefficiency and compensation. Schizophr Res. 2010 Mar; 117(1):42-51. PMID: 20096539; PMCID: PMC2821986.
  54. Ehrlich S, Morrow EM, Roffman JL, Wallace SR, Naylor M, Bockholt HJ, Lundquist A, Yendiki A, Ho BC, White T, Manoach DS, Clark VP, Calhoun VD, Gollub RL, Holt DJ. The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults. Neuroimage. 2010 Nov 15; 53(3):992-1000. PMID: 20026221; PMCID: PMC2888809.
  55. Kim DI, Manoach DS, Mathalon DH, Turner JA, Mannell M, Brown GG, Ford JM, Gollub RL, White T, Wible C, Belger A, Bockholt HJ, Clark VP, Lauriello J, O'Leary D, Mueller BA, Lim KO, Andreasen N, Potkin SG, Calhoun VD. Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study. Hum Brain Mapp. 2009 Nov; 30(11):3795-811. PMID: 19434601; PMCID: PMC3058491.
  56. Sponheim SR, Jung RE, Seidman LJ, Mesholam-Gately RI, Manoach DS, O'Leary DS, Ho BC, Andreasen NC, Lauriello J, Schulz SC. Cognitive deficits in recent-onset and chronic schizophrenia. J Psychiatr Res. 2010 May; 44(7):421-8. PMID: 19878956; PMCID: PMC3940967.
  57. Manoach DS, Stickgold R. Does abnormal sleep impair memory consolidation in schizophrenia? Front Hum Neurosci. 2009; 3:21. PMID: 19750201; PMCID: PMC2741296.
  58. Manoach DS, Thakkar KN, Stroynowski E, Ely A, McKinley SK, Wamsley E, Djonlagic I, Vangel MG, Goff DC, Stickgold R. Reduced overnight consolidation of procedural learning in chronic medicated schizophrenia is related to specific sleep stages. J Psychiatr Res. 2010 Jan; 44(2):112-20. PMID: 19665729; PMCID: PMC2813320.
  59. Polli FE, Wright CI, Milad MR, Dickerson BC, Vangel M, Barton JJ, Rauch SL, Manoach DS. Hemispheric differences in amygdala contributions to response monitoring. Neuroreport. 2009 Mar 04; 20(4):398-402. PMID: 19218865; PMCID: PMC2650381.
  60. Hadjikhani N, Joseph RM, Manoach DS, Naik P, Snyder J, Dominick K, Hoge R, Van den Stock J, Tager Flusberg H, de Gelder B. Body expressions of emotion do not trigger fear contagion in autism spectrum disorder. Soc Cogn Affect Neurosci. 2009 Mar; 4(1):70-8. PMID: 19151375; PMCID: PMC2656879.
  61. Potkin SG, Turner JA, Brown GG, McCarthy G, Greve DN, Glover GH, Manoach DS, Belger A, Diaz M, Wible CG, Ford JM, Mathalon DH, Gollub R, Lauriello J, O'Leary D, van Erp TG, Toga AW, Preda A, Lim KO. Working memory and DLPFC inefficiency in schizophrenia: the FBIRN study. Schizophr Bull. 2009 Jan; 35(1):19-31. PMID: 19042912; PMCID: PMC2643959.
  62. Brown GG, McCarthy G, Bischoff-Grethe A, Ozyurt B, Greve D, Potkin SG, Turner JA, Notestine R, Calhoun VD, Ford JM, Mathalon D, Manoach DS, Gadde S, Glover GH, Wible CG, Belger A, Gollub RL, Lauriello J, O'Leary D, Lim KO. Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approach. Schizophr Bull. 2009 Jan; 35(1):32-46. PMID: 19023127; PMCID: PMC2643949.
  63. Roffman JL, Gollub RL, Calhoun VD, Wassink TH, Weiss AP, Ho BC, White T, Clark VP, Fries J, Andreasen NC, Goff DC, Manoach DS. MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17573-8. PMID: 18988738; PMCID: PMC2582272.
  64. Thakkar KN, Polli FE, Joseph RM, Tuch DS, Hadjikhani N, Barton JJ, Manoach DS. Response monitoring, repetitive behaviour and anterior cingulate abnormalities in autism spectrum disorders (ASD). Brain. 2008 Sep; 131(Pt 9):2464-78. PMID: 18550622; PMCID: PMC2525446.
  65. Stufflebeam SM, Witzel T, Mikulski S, Hämäläinen MS, Temereanca S, Barton JJ, Tuch DS, Manoach DS. A non-invasive method to relate the timing of neural activity to white matter microstructural integrity. Neuroimage. 2008 Aug 15; 42(2):710-6. PMID: 18565766; PMCID: PMC2610633.
  66. Polli FE, Barton JJ, Thakkar KN, Greve DN, Goff DC, Rauch SL, Manoach DS. Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia. Brain. 2008 Apr; 131(Pt 4):971-86. PMID: 18158315.
    View in: PubMed
  67. Barton JJ, Pandita M, Thakkar K, Goff DC, Manoach DS. The relation between antisaccade errors, fixation stability and prosaccade errors in schizophrenia. Exp Brain Res. 2008 Mar; 186(2):273-82. PMID: 18057921.
    View in: PubMed
  68. Barton JJ, Hefter RL, Cherkasova MV, Manoach DS. Investigations of face expertise in the social developmental disorders. Neurology. 2007 Aug 28; 69(9):860-70. PMID: 17724288.
    View in: PubMed
  69. Manoach DS, Ketwaroo GA, Polli FE, Thakkar KN, Barton JJ, Goff DC, Fischl B, Vangel M, Tuch DS. Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia. Neuroimage. 2007 Aug 15; 37(2):599-610. PMID: 17590354.
    View in: PubMed
  70. Wisco JJ, Kuperberg G, Manoach D, Quinn BT, Busa E, Fischl B, Heckers S, Sorensen AG. Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI. Schizophr Res. 2007 Aug; 94(1-3):317-27. PMID: 17490861; PMCID: PMC2034662.
  71. Greenzang C, Manoach DS, Goff DC, Barton JJ. Task-switching in schizophrenia: active switching costs and passive carry-over effects in an antisaccade paradigm. Exp Brain Res. 2007 Aug; 181(3):493-502. PMID: 17486327.
    View in: PubMed
  72. Moon SY, Barton JJ, Mikulski S, Polli FE, Cain MS, Vangel M, Hämäläinen MS, Manoach DS. Where left becomes right: a magnetoencephalographic study of sensorimotor transformation for antisaccades. Neuroimage. 2007 Jul 15; 36(4):1313-23. PMID: 17537647; PMCID: PMC1995561.
  73. Manoach DS, Thakkar KN, Cain MS, Polli FE, Edelman JA, Fischl B, Barton JJ. Neural activity is modulated by trial history: a functional magnetic resonance imaging study of the effects of a previous antisaccade. J Neurosci. 2007 Feb 14; 27(7):1791-8. PMID: 17301186.
    View in: PubMed
  74. Barton JJ, Goff DC, Manoach DS. The inter-trial effects of stimulus and saccadic direction on prosaccades and antisaccades, in controls and schizophrenia patients. Exp Brain Res. 2006 Oct; 174(3):487-98. PMID: 16642313.
    View in: PubMed
  75. Polli FE, Barton JJ, Vangel M, Goff DC, Iguchi L, Manoach DS. Schizophrenia patients show intact immediate error-related performance adjustments on an antisaccade task. Schizophr Res. 2006 Feb 28; 82(2-3):191-201. PMID: 16448804.
    View in: PubMed
  76. Barton JJ, Raoof M, Jameel O, Manoach DS. Task-switching with antisaccades versus no-go trials: a comparison of inter-trial effects. Exp Brain Res. 2006 Jun; 172(1):114-9. PMID: 16369785.
    View in: PubMed
  77. Barton JJ, Kuzin A, Polli F, Manoach DS. The use of working memory for task prediction: what benefits accrue from different types of foreknowledge? Neuroscience. 2006 Apr 28; 139(1):385-92. PMID: 16326018.
    View in: PubMed
  78. Hefter RL, Manoach DS, Barton JJ. Perception of facial expression and facial identity in subjects with social developmental disorders. Neurology. 2005 Nov 22; 65(10):1620-5. PMID: 16301491.
    View in: PubMed
  79. Polli FE, Barton JJ, Cain MS, Thakkar KN, Rauch SL, Manoach DS. Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission. Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43):15700-5. PMID: 16227444; PMCID: PMC1255733.
  80. Manoach DS, White N, Lindgren KA, Heckers S, Coleman MJ, Dubal S, Goff DC, Holzman PS. Intact hemispheric specialization for spatial and shape working memory in schizophrenia. Schizophr Res. 2005 Oct 01; 78(1):1-12. PMID: 16076549.
    View in: PubMed
  81. Barton JJ, Greenzang C, Hefter R, Edelman J, Manoach DS. Switching, plasticity, and prediction in a saccadic task-switch paradigm. Exp Brain Res. 2006 Jan; 168(1-2):76-87. PMID: 16096781.
    View in: PubMed
  82. Barton JJ, Cherkasova MV, Lindgren KA, Goff DC, Manoach DS. What is perseverated in schizophrenia? Evidence of abnormal response plasticity in the saccadic system. J Abnorm Psychol. 2005 Feb; 114(1):75-84. PMID: 15709814.
    View in: PubMed
  83. Manoach DS, Cain MS, Vangel MG, Khurana A, Goff DC, Stickgold R. A failure of sleep-dependent procedural learning in chronic, medicated schizophrenia. Biol Psychiatry. 2004 Dec 15; 56(12):951-6. PMID: 15601605.
    View in: PubMed
  84. Manoach DS, Lindgren KA, Barton JJ. Deficient saccadic inhibition in Asperger's disorder and the social-emotional processing disorder. J Neurol Neurosurg Psychiatry. 2004 Dec; 75(12):1719-26. PMID: 15548490; PMCID: PMC1738855.
  85. Long C, Brown EN, Manoach D, Solo V. Spatiotemporal wavelet analysis for functional MRI. Neuroimage. 2004 Oct; 23(2):500-16. PMID: 15488399.
    View in: PubMed
  86. Ramchandran RS, Manoach DS, Cherkasova MV, Lindgren KA, Goff DC, Barton JJ. The relationship of saccadic peak velocity to latency: evidence for a new prosaccadic abnormality in schizophrenia. Exp Brain Res. 2004 Nov; 159(1):99-107. PMID: 15480590.
    View in: PubMed
  87. Barton JJ, Cherkasova MV, Hefter R, Cox TA, O'Connor M, Manoach DS. Are patients with social developmental disorders prosopagnosic? Perceptual heterogeneity in the Asperger and socio-emotional processing disorders. Brain. 2004 Aug; 127(Pt 8):1706-16. PMID: 15215211.
    View in: PubMed
  88. Manoach DS, White NS, Lindgren KA, Heckers S, Coleman MJ, Dubal S, Holzman PS. Hemispheric specialization of the lateral prefrontal cortex for strategic processing during spatial and shape working memory. Neuroimage. 2004 Mar; 21(3):894-903. PMID: 15006656.
    View in: PubMed
  89. Manoach DS, Greve DN, Lindgren KA, Dale AM. Identifying regional activity associated with temporally separated components of working memory using event-related functional MRI. Neuroimage. 2003 Nov; 20(3):1670-84. PMID: 14642477.
    View in: PubMed
  90. Manoach DS. Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophr Res. 2003 Apr 01; 60(2-3):285-98. PMID: 12591590.
    View in: PubMed
  91. Press DZ, Mechanic DJ, Tarsy D, Manoach DS. Cognitive slowing in Parkinson's disease resolves after practice. J Neurol Neurosurg Psychiatry. 2002 Nov; 73(5):524-8. PMID: 12397144; PMCID: PMC1738096.
  92. Pascual-Leone A, Manoach DS, Birnbaum R, Goff DC. Motor cortical excitability in schizophrenia. Biol Psychiatry. 2002 Jul 01; 52(1):24-31. PMID: 12079727.
    View in: PubMed
  93. Manoach DS, Lindgren KA, Cherkasova MV, Goff DC, Halpern EF, Intriligator J, Barton JJ. Schizophrenic subjects show deficient inhibition but intact task switching on saccadic tasks. Biol Psychiatry. 2002 May 15; 51(10):816-26. PMID: 12007456.
    View in: PubMed
  94. Cherkasova MV, Manoach DS, Intriligator JM, Barton JJ. Antisaccades and task-switching: interactions in controlled processing. Exp Brain Res. 2002 Jun; 144(4):528-37. PMID: 12037637.
    View in: PubMed
  95. Barton JJ, Cherkasova MV, Lindgren K, Goff DC, Intriligator JM, Manoach DS. Antisaccades and task switching: studies of control processes in saccadic function in normal subjects and schizophrenic patients. Ann N Y Acad Sci. 2002 Apr; 956:250-63. PMID: 11960809.
    View in: PubMed
  96. Manoach DS, Halpern EF, Kramer TS, Chang Y, Goff DC, Rauch SL, Kennedy DN, Gollub RL. Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects. Am J Psychiatry. 2001 Jun; 158(6):955-8. PMID: 11384907.
    View in: PubMed
  97. Knight RA, Manoach DS, Elliott DS, Hershenson M. Perceptual organization in schizophrenia: the processing of symmetrical configurations. J Abnorm Psychol. 2000 Nov; 109(4):575-87. PMID: 11195981.
    View in: PubMed
  98. Manoach DS, Gollub RL, Benson ES, Searl MM, Goff DC, Halpern E, Saper CB, Rauch SL. Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance. Biol Psychiatry. 2000 Jul 15; 48(2):99-109. PMID: 10903406.
    View in: PubMed
  99. Manoach DS, Press DZ, Thangaraj V, Searl MM, Goff DC, Halpern E, Saper CB, Warach S. Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI. Biol Psychiatry. 1999 May 01; 45(9):1128-37. PMID: 10331104.
    View in: PubMed
  100. Goff DC, Tsai G, Levitt J, Amico E, Manoach D, Schoenfeld DA, Hayden DL, McCarley R, Coyle JT. A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Arch Gen Psychiatry. 1999 Jan; 56(1):21-7. PMID: 9892252.
    View in: PubMed
  101. Manoach DS, Weintraub S, Daffner KR, Scinto LF. Deficient antisaccades in the social-emotional processing disorder. Neuroreport. 1997 Mar 03; 8(4):901-5. PMID: 9141061.
    View in: PubMed
  102. Manoach DS, Schlaug G, Siewert B, Darby DG, Bly BM, Benfield A, Edelman RR, Warach S. Prefrontal cortex fMRI signal changes are correlated with working memory load. Neuroreport. 1997 Jan 20; 8(2):545-9. PMID: 9080445.
    View in: PubMed
  103. Goff DC, Tsai G, Manoach DS, Flood J, Darby DG, Coyle JT. D-cycloserine added to clozapine for patients with schizophrenia. Am J Psychiatry. 1996 Dec; 153(12):1628-30. PMID: 8942463.
    View in: PubMed
  104. Manoach DS, O'Connor M, Weintraub S. Absence of neglect for mental representations during the intracarotid amobarbital procedure. Arch Neurol. 1996 Apr; 53(4):333-6. PMID: 8929155.
    View in: PubMed
  105. Goff DC, Tsai G, Manoach DS, Coyle JT. Dose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia. Am J Psychiatry. 1995 Aug; 152(8):1213-5. PMID: 7625475.
    View in: PubMed
  106. Sandson TA, Manoach DS, Price BH, Rentz D, Weintraub S. Right hemisphere learning disability associated with left hemisphere dysfunction: anomalous dominance and development. J Neurol Neurosurg Psychiatry. 1994 Sep; 57(9):1129-32. PMID: 8089686; PMCID: PMC1073144.
  107. Manoach DS. Handedness is related to formal thought disorder and language dysfunction in schizophrenia. J Clin Exp Neuropsychol. 1994 Feb; 16(1):2-14. PMID: 8150887.
    View in: PubMed
  108. Hudson JI, Manoach DS, Sabo AN, Sternbach SE. Recurrent nightmares in posttraumatic stress disorder: association with sleep paralysis, hypnopompic hallucinations, and REM sleep. J Nerv Ment Dis. 1991 Sep; 179(9):572-3. PMID: 1919561.
    View in: PubMed
  109. Manoach DS, Maher BA, Manschreck TC. Left-handedness and though disorder in the schizophrenias. J Abnorm Psychol. 1988 Feb; 97(1):97-9. PMID: 3351121.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact For demographic and contact information changes only, HMS/HSDM faculty should contact Human Resources at
Manoach's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts Expand Description
Co-Authors Expand Description
Similar People Expand Description
Same Department Expand Description
Physical Neighbors Expand Description