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Dara Sue Manoach, Ph.D.

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Biography
Harvard University PhD 1989Psychology

Overview
I am a neuropsychologist and cognitive neuroscientist. My group, the Sleep, Cognition and Neuropsychiatry Laboratory, SCAN Lab, investigates cognitive deficits in neurodevelopmental disorders that are profoundly disabling and for which effective treatment is lacking. We are using state-of-the-art complementary multimodal neuroimaging techniques, including MEG, EEG and functional MRI, to understand the contribution of abnormal sleep to the cognitive deficits and symptoms of schizophrenia, autism spectrum disorder and pediatric epilepsy. We are guided by the principle that understanding the bases of cognitive deficits, from genes to physiology to circuit dysfunction to diagnosis, will lead to effective prevention and treatment. To achieve this goal, we collaborate with a multidisciplinary team of researchers. Our group has identified deficient sleep-dependent memory consolidation as a cognitive deficit of schizophrenia and has linked it to abnormalities of specific brain oscillations during sleep. In addition to further characterizing the genetic and neural bases of this deficit, we are developing and evaluating novel treatments targeting its mechanism. The ultimate goal of this research program is to transform our understanding and treatment of neurodevelopmental disorders, to prevent their onset and to improve outcomes.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. UH3MH125273 (MANOACH, DARA S) Jan 1, 2021 - Dec 31, 2024
    NIH
    Optimizing sleep spindle measurements as translational assays of memory consolidation
    Role: Principal Investigator
  2. UG3MH125273 (MANOACH, DARA S ;VARELA, CARMEN) Jan 1, 2021 - Dec 31, 2022
    NIH
    Optimizing sleep spindle measurements as translational assays of memory consolidation
    Role: Principal Investigator
  3. R01MH107579 (KESHAVAN, MATCHERI S.) Sep 7, 2015 - May 31, 2021
    NIH
    Sleep spindles in early course schizophrenia and first-degree relatives
    Role: Co-Principal Investigator
  4. K24MH099421 (MANOACH, DARA S) Dec 1, 2012 - Nov 30, 2018
    NIH
    Mentoring and Research on Cognitive Deficits in Schizophrenia
    Role: Principal Investigator
  5. R01MH092638 (MANOACH, DARA S) Jul 1, 2012 - Dec 31, 2027
    NIH
    Offline memory processing in schizophrenia
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.