Harvard Catalyst Profiles

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Hans R.V. Widlund, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03CA212987 (WIDLUND, HANS RAGNAR) Aug 1, 2017 - Jul 31, 2019
    Exploring mechanisms to increase cancer cell antigenicity by modulating lineage-specific transcription in tumors
    Role: Principal Investigator
  2. R01CA207982 (WIDLUND, HANS RAGNAR) Jan 17, 2016 - Dec 31, 2021
    Coordinating tumor differentiation and immune suppression with the metabolic state and treatment outcome
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zarei M, Giannikou K, Du H, Liu HJ, Duarte M, Johnson S, Nassar AH, Widlund HR, Henske EP, Long HW, Kwiatkowski DJ. MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61. Oncogene. 2021 01; 40(1):112-126. PMID: 33082558.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  2. Tian T, Lofftus S, Pan Y, Stingley CA, King SL, Zhao J, Pan TY, Lock R, Marglous JW, Liu K, Widlund HR, Fuhlbrigge RC, Cichowski K, Kupper TS. IL1a Antagonizes IL1ß and Promotes Adaptive Immune Rejection of Malignant Tumors. Cancer Immunol Res. 2020 05; 8(5):660-671. PMID: 32161110.
    Citations: 6     Fields:    Translation:AnimalsCells
  3. Luo C, Balsa E, Perry EA, Liang J, Tavares CD, Vazquez F, Widlund HR, Puigserver P. H3K27me3-mediated PGC1a gene silencing promotes melanoma invasion through WNT5A and YAP. J Clin Invest. 2020 02 03; 130(2):853-862. PMID: 31929186.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  4. O'Malley JT, Clark RA, Widlund HR. Skin Inflammation in Human Health and Disease: 2018 International Conference. J Invest Dermatol. 2019 05; 139(5):991-994. PMID: 30684557.
    Citations:    Fields:    Translation:Humans
  5. Giovannone N, Antonopoulos A, Liang J, Geddes Sweeney J, Kudelka MR, King SL, Lee GS, Cummings RD, Dell A, Barthel SR, Widlund HR, Haslam SM, Dimitroff CJ. Human B Cell Differentiation Is Characterized by Progressive Remodeling of O-Linked Glycans. Front Immunol. 2018; 9:2857. PMID: 30619255.
    Citations: 7     Fields:    Translation:HumansCells
  6. Sweeney JG, Liang J, Antonopoulos A, Giovannone N, Kang S, Mondala TS, Head SR, King SL, Tani Y, Brackett D, Dell A, Murphy GF, Haslam SM, Widlund HR, Dimitroff CJ. Loss of GCNT2/I-branched glycans enhances melanoma growth and survival. Nat Commun. 2018 08 22; 9(1):3368. PMID: 30135430.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  7. Giovannone N, Liang J, Antonopoulos A, Geddes Sweeney J, King SL, Pochebit SM, Bhattacharyya N, Lee GS, Dell A, Widlund HR, Haslam SM, Dimitroff CJ. Galectin-9 suppresses B cell receptor signaling and is regulated by I-branching of N-glycans. Nat Commun. 2018 08 17; 9(1):3287. PMID: 30120234.
    Citations: 29     Fields:    Translation:HumansCells
  8. Luo C, Balsa E, Thomas A, Hatting M, Jedrychowski M, Gygi SP, Widlund HR, Puigserver P. ERRa Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1a-Elevated Melanomas. Mol Cancer Res. 2017 10; 15(10):1366-1375. PMID: 28596418.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  9. Ilic N, Birsoy K, Aguirre AJ, Kory N, Pacold ME, Singh S, Moody SE, DeAngelo JD, Spardy NA, Freinkman E, Weir BA, Tsherniak A, Cowley GS, Root DE, Asara JM, Vazquez F, Widlund HR, Sabatini DM, Hahn WC. PIK3CA mutant tumors depend on oxoglutarate dehydrogenase. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):E3434-E3443. PMID: 28396387.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  10. Wang B, Krall EB, Aguirre AJ, Kim M, Widlund HR, Doshi MB, Sicinska E, Sulahian R, Goodale A, Cowley GS, Piccioni F, Doench JG, Root DE, Hahn WC. ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition. Cell Rep. 2017 02 07; 18(6):1543-1557. PMID: 28178529.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  11. Cao J, Tyburczy ME, Moss J, Darling TN, Widlund HR, Kwiatkowski DJ. Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation. J Clin Invest. 2017 01 03; 127(1):349-364. PMID: 27918305.
    Citations: 24     Fields:    Translation:HumansCells
  12. Luo C, Widlund HR, Puigserver P. PGC-1 Coactivators: Shepherding the Mitochondrial Biogenesis of Tumors. Trends Cancer. 2016 10; 2(10):619-631. PMID: 28607951.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  13. Luo C, Lim JH, Lee Y, Granter SR, Thomas A, Vazquez F, Widlund HR, Puigserver P. A PGC1a-mediated transcriptional axis suppresses melanoma metastasis. Nature. 2016 09 15; 537(7620):422-426. PMID: 27580028.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  14. Luo C, Puigserver P, Widlund HR. Breaking BRAF(V600E)-drug resistance by stressing mitochondria. Pigment Cell Melanoma Res. 2016 07; 29(4):401-3. PMID: 27135210.
    Citations: 3     Fields:    Translation:HumansCells
  15. Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. J Invest Dermatol. 2015 Jul; 135(7):1849-1862. PMID: 25756799.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  16. Dadras SS, Lin RJ, Razavi G, Kawakami A, Du J, Feige E, Milner DA, Loda MF, Granter SR, Detmar M, Widlund HR, Horstmann MA, Fisher DE. A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression. Am J Pathol. 2015 Jan; 185(1):252-65. PMID: 25447045.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Haq R, Fisher DE, Widlund HR. Molecular pathways: BRAF induces bioenergetic adaptation by attenuating oxidative phosphorylation. Clin Cancer Res. 2014 May 01; 20(9):2257-63. PMID: 24610826.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  18. Nambudiri VE, Widlund HR. Small interfering RNA. J Invest Dermatol. 2013 Dec; 133(12):1-4. PMID: 24216786.
    Citations: 3     Fields:    Translation:Humans
  19. Degen M, Barron P, Natarajan E, Widlund HR, Rheinwald JG. RSK activation of translation factor eIF4B drives abnormal increases of laminin ?2 and MYC protein during neoplastic progression to squamous cell carcinoma. PLoS One. 2013; 8(10):e78979. PMID: 24205356.
    Citations: 5     Fields:    Translation:HumansCells
  20. Li WQ, Han J, Widlund HR, Correll M, Wang YE, Quackenbush J, Mihm MC, Canales AL, Wu S, Golub T, Hoshida Y, Hunter DJ, Murphy G, Kupper TS, Qureshi AA. CXCR4 pathway associated with family history of melanoma. Cancer Causes Control. 2014 Jan; 25(1):125-32. PMID: 24158781.
    Citations: 3     Fields:    Translation:HumansCells
  21. Cao J, Wan L, Hacker E, Dai X, Lenna S, Jimenez-Cervantes C, Wang Y, Leslie NR, Xu GX, Widlund HR, Ryu B, Alani RM, Dutton-Regester K, Goding CR, Hayward NK, Wei W, Cui R. MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol Cell. 2013 Aug 22; 51(4):409-22. PMID: 23973372.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  22. Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR. Oncogenic BRAF regulates oxidative metabolism via PGC1a and MITF. Cancer Cell. 2013 Mar 18; 23(3):302-15. PMID: 23477830.
    Citations: 365     Fields:    Translation:HumansCells
  23. Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P. PGC1a expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 2013 Mar 18; 23(3):287-301. PMID: 23416000.
    Citations: 315     Fields:    Translation:HumansAnimalsCells
  24. Jalili A, Wagner C, Pashenkov M, Pathria G, Mertz KD, Widlund HR, Lupien M, Brunet JP, Golub TR, Stingl G, Fisher DE, Ramaswamy S, Wagner SN. Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma. J Natl Cancer Inst. 2012 Nov 07; 104(21):1673-9. PMID: 22997239.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  25. Degen M, Natarajan E, Barron P, Widlund HR, Rheinwald JG. MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin ?2 expression in oral dysplasia and squamous cell carcinoma. Am J Pathol. 2012 Jun; 180(6):2462-78. PMID: 22546478.
    Citations: 20     Fields:    Translation:HumansCells
  26. Girouard SD, Laga AC, Mihm MC, Scolyer RA, Thompson JF, Zhan Q, Widlund HR, Lee CW, Murphy GF. SOX2 contributes to melanoma cell invasion. Lab Invest. 2012 Mar; 92(3):362-70. PMID: 22184093.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  27. Anders L, Ke N, Hydbring P, Choi YJ, Widlund HR, Chick JM, Zhai H, Vidal M, Gygi SP, Braun P, Sicinski P. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells. Cancer Cell. 2011 Nov 15; 20(5):620-34. PMID: 22094256.
    Citations: 235     Fields:    Translation:HumansCells
  28. Feige E, Yokoyama S, Levy C, Khaled M, Igras V, Lin RJ, Lee S, Widlund HR, Granter SR, Kung AL, Fisher DE. Hypoxia-induced transcriptional repression of the melanoma-associated oncogene MITF. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):E924-33. PMID: 21949374.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  29. Ilic N, Utermark T, Widlund HR, Roberts TM. PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):E699-708. PMID: 21876152.
    Citations: 120     Fields:    Translation:HumansCells
  30. Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH. VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res. 2011 Feb 15; 71(4):1474-85. PMID: 21212411.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  31. Stewart RA, Sanda T, Widlund HR, Zhu S, Swanson KD, Hurley AD, Bentires-Alj M, Fisher DE, Kontaridis MI, Look AT, Neel BG. Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev Cell. 2010 May 18; 18(5):750-62. PMID: 20493809.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  32. Jané-Valbuena J, Widlund HR, Perner S, Johnson LA, Dibner AC, Lin WM, Baker AC, Nazarian RM, Vijayendran KG, Sellers WR, Hahn WC, Duncan LM, Rubin MA, Fisher DE, Garraway LA. An oncogenic role for ETV1 in melanoma. Cancer Res. 2010 Mar 01; 70(5):2075-84. PMID: 20160028.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  33. Scott KL, Kabbarah O, Liang MC, Ivanova E, Anagnostou V, Wu J, Dhakal S, Wu M, Chen S, Feinberg T, Huang J, Saci A, Widlund HR, Fisher DE, Xiao Y, Rimm DL, Protopopov A, Wong KK, Chin L. GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature. 2009 Jun 25; 459(7250):1085-90. PMID: 19553991.
    Citations: 191     Fields:    Translation:HumansAnimalsCells
  34. Jiang X, Zhou J, Yuen NK, Corless CL, Heinrich MC, Fletcher JA, Demetri GD, Widlund HR, Fisher DE, Hodi FS. Imatinib targeting of KIT-mutant oncoprotein in melanoma. Clin Cancer Res. 2008 Dec 01; 14(23):7726-32. PMID: 19047099.
    Citations: 49     Fields:    Translation:HumansCells
  35. Yokoyama S, Feige E, Poling LL, Levy C, Widlund HR, Khaled M, Kung AL, Fisher DE. Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage. Pigment Cell Melanoma Res. 2008 Aug; 21(4):457-63. PMID: 18627530.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  36. Widlund HR, Fisher DE. Potent p53-independent tumor suppressor activity of ARF in melanoma-genesis. Pigment Cell Res. 2007 Oct; 20(5):339-40. PMID: 17850505.
    Citations: 2     Fields:    Translation:Humans
  37. Cui R, Widlund HR, Feige E, Lin JY, Wilensky DL, Igras VE, D'Orazio J, Fung CY, Schanbacher CF, Granter SR, Fisher DE. Central role of p53 in the suntan response and pathologic hyperpigmentation. Cell. 2007 Mar 09; 128(5):853-64. PMID: 17350573.
    Citations: 203     Fields:    Translation:HumansAnimalsCells
  38. Davis IJ, Kim JJ, Ozsolak F, Widlund HR, Rozenblatt-Rosen O, Granter SR, Du J, Fletcher JA, Denny CT, Lessnick SL, Linehan WM, Kung AL, Fisher DE. Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer Cell. 2006 Jun; 9(6):473-84. PMID: 16766266.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  39. Sun T, Hafler BP, Kaing S, Kitada M, Ligon KL, Widlund HR, Yuk DI, Stiles CD, Rowitch DH. Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Dev Biol. 2006 Apr 01; 292(1):152-64. PMID: 16469306.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  40. Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S, Beroukhim R, Milner DA, Granter SR, Du J, Lee C, Wagner SN, Li C, Golub TR, Rimm DL, Meyerson ML, Fisher DE, Sellers WR. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature. 2005 Jul 07; 436(7047):117-22. PMID: 16001072.
    Citations: 576     Fields:    Translation:HumansCells
  41. Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD, Berghmans S, Mayhall EA, Traver D, Fletcher CD, Aster JC, Granter SR, Look AT, Lee C, Fisher DE, Zon LI. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol. 2005 Feb 08; 15(3):249-54. PMID: 15694309.
    Citations: 235     Fields:    Translation:AnimalsCells
  42. Garraway LA, Weir BA, Zhao X, Widlund H, Beroukhim R, Berger A, Rimm D, Rubin MA, Fisher DE, Meyerson ML, Sellers WR. "Lineage addiction" in human cancer: lessons from integrated genomics. Cold Spring Harb Symp Quant Biol. 2005; 70:25-34. PMID: 16869735.
    Citations: 12     Fields:    Translation:HumansCells
  43. Du J, Widlund HR, Horstmann MA, Ramaswamy S, Ross K, Huber WE, Nishimura EK, Golub TR, Fisher DE. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell. 2004 Dec; 6(6):565-76. PMID: 15607961.
    Citations: 147     Fields:    Translation:HumansCells
  44. Miller AJ, Du J, Rowan S, Hershey CL, Widlund HR, Fisher DE. Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Cancer Res. 2004 Jan 15; 64(2):509-16. PMID: 14744763.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  45. Kenney AM, Widlund HR, Rowitch DH. Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors. Development. 2004 Jan; 131(1):217-28. PMID: 14660435.
    Citations: 100     Fields:    Translation:AnimalsCells
  46. Huber WE, Price ER, Widlund HR, Du J, Davis IJ, Wegner M, Fisher DE. A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes. J Biol Chem. 2003 Nov 14; 278(46):45224-30. PMID: 12944398.
    Citations: 32     Fields:    Translation:HumansCells
  47. Du J, Miller AJ, Widlund HR, Horstmann MA, Ramaswamy S, Fisher DE. MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma. Am J Pathol. 2003 Jul; 163(1):333-43. PMID: 12819038.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  48. Widlund HR, Fisher DE. Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival. Oncogene. 2003 May 19; 22(20):3035-41. PMID: 12789278.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  49. Baksh S, Widlund HR, Frazer-Abel AA, Du J, Fosmire S, Fisher DE, DeCaprio JA, Modiano JF, Burakoff SJ. NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell. 2002 Nov; 10(5):1071-81. PMID: 12453415.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  50. Widlund HR, Horstmann MA, Price ER, Cui J, Lessnick SL, Wu M, He X, Fisher DE. Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol. 2002 Sep 16; 158(6):1079-87. PMID: 12235125.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  51. McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, Lin YL, Ramaswamy S, Avery W, Ding HF, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell. 2002 Jun 14; 109(6):707-18. PMID: 12086670.
    Citations: 233     Fields:    Translation:HumansAnimalsCells
  52. Widlund HR, Vitolo JM, Thiriet C, Hayes JJ. DNA sequence-dependent contributions of core histone tails to nucleosome stability: differential effects of acetylation and proteolytic tail removal. Biochemistry. 2000 Apr 04; 39(13):3835-41. PMID: 10736184.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  53. Widlund HR, Kuduvalli PN, Bengtsson M, Cao H, Tullius TD, Kubista M. Nucleosome structural features and intrinsic properties of the TATAAACGCC repeat sequence. J Biol Chem. 1999 Nov 05; 274(45):31847-52. PMID: 10542209.
    Citations: 23     Fields:    Translation:AnimalsCells
  54. Thåström A, Lowary PT, Widlund HR, Cao H, Kubista M, Widom J. Sequence motifs and free energies of selected natural and non-natural nucleosome positioning DNA sequences. J Mol Biol. 1999 Apr 30; 288(2):213-29. PMID: 10329138.
    Citations: 166     Fields:    Translation:AnimalsCells
  55. Cao H, Widlund HR, Simonsson T, Kubista M. TGGA repeats impair nucleosome formation. J Mol Biol. 1998 Aug 14; 281(2):253-60. PMID: 9698546.
    Citations: 21     Fields:    Translation:AnimalsCells
  56. Widlund HR, Cao H, Simonsson S, Magnusson E, Simonsson T, Nielsen PE, Kahn JD, Crothers DM, Kubista M. Identification and characterization of genomic nucleosome-positioning sequences. J Mol Biol. 1997 Apr 11; 267(4):807-17. PMID: 9135113.
    Citations: 57     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.