Harvard Catalyst Profiles

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Ellen Martha Gravallese, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AR072836 (GRAVALLESE, ELLEN M) Sep 25, 2017 - Jul 31, 2019
    NIH/NIAMS
    Novel approaches to the treatment of bone loss in rheumatoid arthritis
    Role: Principal Investigator
  2. R01AR071037 (GRAVALLESE, ELLEN M) Jul 19, 2017 - May 31, 2022
    NIH/NIAMS
    The STING pathway and cytosolic nucleic acid sensors in bone homeostasis
    Role: Principal Investigator
  3. R21AR067394 (GRAVALLESE, ELLEN M) Sep 1, 2014 - Aug 31, 2016
    NIH/NIAMS
    Regulatory role for cytosolic nucleic acid sensors in bone
    Role: Principal Investigator
  4. R01AR055952 (GRAVALLESE, ELLEN M) Jul 17, 2009 - Jun 30, 2014
    NIH/NIAMS
    Inhibition of osteoblast function in bone erosion in rheumatoid arthritis
    Role: Principal Investigator
  5. R01AR047665 (GRAVALLESE, ELLEN M) Jan 1, 2003 - Dec 31, 2008
    NIH/NIAMS
    PATHOGENESIS OF BONE EROSION IN RHEUMATOID ARTHRITIS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Orange DE, Blachere NE, DiCarlo EF, Mirza S, Pannellini T, Jiang CS, Frank MO, Parveen S, Figgie MP, Gravallese EM, Bykerk VP, Orbai AM, Mackie SL, Goodman SM. Rheumatoid arthritis morning stiffness is associated with synovial fibrin and neutrophils. Arthritis Rheumatol. 2019 Oct 15. PMID: 31612614.
    Citations:    
  2. Pawaria S, Nündel K, Gao KM, Moses S, Busto P, Holt K, Sharma RB, Brehm MA, Gravallese EM, Socolovsky M, Christ A, Marshak-Rothstein A. Role of Interferon-?-Producing Th1 Cells in a Murine Model of Type I Interferon-Independent Autoinflammation Resulting From DNase II Deficiency. Arthritis Rheumatol. 2019 Aug 28. PMID: 31464028.
    Citations:    
  3. Yang YS, Xie J, Wang D, Kim JM, Tai PWL, Gravallese E, Gao G, Shim JH. Bone-targeting AAV-mediated silencing of Schnurri-3 prevents bone loss in osteoporosis. Nat Commun. 2019 07 04; 10(1):2958. PMID: 31273195.
    Citations:    
  4. Orange DE, Agius P, DiCarlo EF, Mirza SZ, Pannellini T, Szymonifka J, Jiang CS, Figgie MP, Frank MO, Robinson WH, Donlin LT, Rozo C, Gravallese EM, Bykerk VP, Goodman SM. Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission. Arthritis Rheumatol. 2019 07; 71(7):1034-1041. PMID: 30835943.
    Citations:    
  5. Henchie TF, Gravallese EM, Bredbenner TL, Troy KL. An image-based method to measure joint deformity in inflammatory arthritis: development and pilot study. Comput Methods Biomech Biomed Engin. 2019 Aug; 22(10):942-952. PMID: 31064209.
    Citations:    
  6. Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM, Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat Immunol. 2019 07; 20(7):928-942. PMID: 31061532.
    Citations:    
  7. Gravallese EM, Schett G. Effects of the IL-23-IL-17 pathway on bone in spondyloarthritis. Nat Rev Rheumatol. 2018 11; 14(11):631-640. PMID: 30266977.
    Citations:    
  8. Gregersen PK, Gravallese EM. Breathing New Life into Interstitial Lung Disease in Rheumatoid Arthritis. N Engl J Med. 2018 12 06; 379(23):2265-2266. PMID: 30345908.
    Citations:    
  9. Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH. Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue Arthritis Res Ther. 2018 07 11; 20(1):139. PMID: 29996944.
    Citations: 2     Fields:    
  10. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM. Author Correction: Towards an arthritis flare-responsive drug delivery system. Nat Commun. 2018 05 11; 9(1):1954. PMID: 29752435.
    Citations:    Fields:    
  11. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM. Towards an arthritis flare-responsive drug delivery system. Nat Commun. 2018 04 03; 9(1):1275. PMID: 29615615.
    Citations:    Fields:    Translation:HumansAnimalsCells
  12. Orange DE, Agius P, DiCarlo EF, Robine N, Geiger H, Szymonifka J, McNamara M, Cummings R, Andersen KM, Mirza S, Figgie M, Ivashkiv LB, Pernis AB, Jiang CS, Frank MO, Darnell RB, Lingampali N, Robinson WH, Gravallese E, Bykerk VP, Goodman SM, Donlin LT. Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data. Arthritis Rheumatol. 2018 05; 70(5):690-701. PMID: 29468833.
    Citations:    
  13. Bridges SL, White DW, Worthing AB, Gravallese EM, O'Dell JR, Nola K, Kay J, Cohen SB. The Science Behind Biosimilars: Entering a New Era of Biologic Therapy. Arthritis Rheumatol. 2018 03; 70(3):334-344. PMID: 29411547.
    Citations:    
  14. Gravallese EM, Kay J, Duryea J, Solomon DH. Reply. Arthritis Rheumatol. 2018 03; 70(3):476. PMID: 29193854.
    Citations:    Fields:    Translation:Humans
  15. Shim JH, Stavre Z, Gravallese EM. Bone Loss in Rheumatoid Arthritis: Basic Mechanisms and Clinical Implications. Calcif Tissue Int. 2018 05; 102(5):533-546. PMID: 29204672.
    Citations:    
  16. Solomon DH, Kay J, Duryea J, Lu B, Bolster MB, Yood RA, Han R, Ball S, Coleman C, Lo E, Wohlfahrt A, Sury M, Yin M, Yu Z, Zak A, Gravallese EM. Effects of Teriparatide on Joint Erosions in Rheumatoid Arthritis: A Randomized Controlled Trial. Arthritis Rheumatol. 2017 09; 69(9):1741-1750. PMID: 28544807.
    Citations: 3     Fields:    Translation:Humans
  17. Baum R, Sharma S, Organ JM, Jakobs C, Hornung V, Burr DB, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM. STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice. Arthritis Rheumatol. 2017 Feb; 69(2):460-471. PMID: 27740718.
    Citations:    
  18. Gravallese EM. Bone Wasn't Built in a Day: Destruction and Formation of Bone in the Rheumatic Diseases. Trans Am Clin Climatol Assoc. 2017; 128:24-43. PMID: 28790485.
    Citations:    
  19. O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF. RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis. Arthritis Rheumatol. 2016 12; 68(12):2889-2900. PMID: 27563728.
    Citations: 6     Fields:    Translation:Animals
  20. Stavre Z, Upchurch K, Kay J, Gravallese EM. Differential Effects of Inflammation on Bone and Response to Biologics in Rheumatoid Arthritis and Spondyloarthritis. Curr Rheumatol Rep. 2016 Dec; 18(12):72. PMID: 27812955.
    Citations:    
  21. Maeda Y, Farina NH, Matzelle MM, Fanning PJ, Lian JB, Gravallese EM. Synovium-Derived MicroRNAs Regulate Bone Pathways in Rheumatoid Arthritis. J Bone Miner Res. 2017 Mar; 32(3):461-472. PMID: 27676131.
    Citations:    
  22. Pawaria S, Sharma S, Baum R, Nündel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent? J Leukoc Biol. 2017 01; 101(1):121-126. PMID: 27531928.
    Citations:    
  23. Baum R, Gravallese EM. Bone as a Target Organ in Rheumatic Disease: Impact on Osteoclasts and Osteoblasts. Clin Rev Allergy Immunol. 2016 Aug; 51(1):1-15. PMID: 26411424.
    Citations:    
  24. Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D. Control of the innate immune response by the mevalonate pathway. Nat Immunol. 2016 08; 17(8):922-9. PMID: 27270400.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  25. Shaw AT, Maeda Y, Gravallese EM. IL-17A deficiency promotes periosteal bone formation in a model of inflammatory arthritis. Arthritis Res Ther. 2016 05 10; 18(1):104. PMID: 27165410.
    Citations:    
  26. Matzelle MM, Shaw AT, Baum R, Maeda Y, Li J, Karmakar S, Manning CA, Walsh NC, Rosen V, Gravallese EM. Inflammation in arthritis induces expression of BMP3, an inhibitor of bone formation. Scand J Rheumatol. 2016 Oct; 45(5):379-83. PMID: 26982203.
    Citations:    
  27. Duryea J, Russell R, Gravallese EM, Kay J, Han R, Lu B, Solomon DH. Brief Report: Development and Validation of a Semiautomated Method to Measure Erosion Volume in Inflammatory Arthritis by Computed Tomography Scanning. Arthritis Rheumatol. 2016 Feb; 68(2):332-6. PMID: 26473501.
    Citations:    Fields:    Translation:Humans
  28. Baum R, Nündel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A. Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice. J Immunol. 2016 Feb 01; 196(3):1348-54. PMID: 26729810.
    Citations:    
  29. Duffau P, Menn-Josephy H, Cuda CM, Dominguez S, Aprahamian TR, Watkins AA, Yasuda K, Monach P, Lafyatis R, Rice LM, Kenneth Haines G, Gravallese EM, Baum R, Richez C, Perlman H, Bonegio RG, Rifkin IR. Promotion of Inflammatory Arthritis by Interferon Regulatory Factor 5 in a Mouse Model. Arthritis Rheumatol. 2015 Dec; 67(12):3146-57. PMID: 26315890.
    Citations: 8     Fields:    Translation:AnimalsCells
  30. Shaw AT, Gravallese EM. Mediators of inflammation and bone remodeling in rheumatic disease. Semin Cell Dev Biol. 2016 Jan; 49:2-10. PMID: 26481971.
    Citations:    
  31. Pawaria S, Moody KL, Busto P, Nündel K, Baum R, Sharma S, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A. An unexpected role for RNA-sensing toll-like receptors in a murine model of DNA accrual. Clin Exp Rheumatol. 2015 Jul-Aug; 33(4 Suppl 92):S70-3. PMID: 26457825.
    Citations:    
  32. Baum R, Sharma S, Carpenter S, Li QZ, Busto P, Fitzgerald KA, Marshak-Rothstein A, Gravallese EM. Cutting edge: AIM2 and endosomal TLRs differentially regulate arthritis and autoantibody production in DNase II-deficient mice. J Immunol. 2015 Feb 01; 194(3):873-7. PMID: 25548216.
    Citations:    
  33. Kim SJ, Chen Z, Chamberlain ND, Essani AB, Volin MV, Amin MA, Volkov S, Gravallese EM, Arami S, Swedler W, Lane NE, Mehta A, Sweiss N, Shahrara S. Ligation of TLR5 promotes myeloid cell infiltration and differentiation into mature osteoclasts in rheumatoid arthritis and experimental arthritis. J Immunol. 2014 Oct 15; 193(8):3902-13. PMID: 25200955.
    Citations:    
  34. Schmidt-Lauber C, Bossaller L, Abujudeh HH, Vladimer GI, Christ A, Fitzgerald KA, Latz E, Gravallese EM, Marshak-Rothstein A, Kay J. Gadolinium-based compounds induce NLRP3-dependent IL-1ß production and peritoneal inflammation. Ann Rheum Dis. 2015 Nov; 74(11):2062-9. PMID: 24914072.
    Citations: 5     Fields:    Translation:AnimalsCells
  35. Baum R, Gravallese EM. Impact of inflammation on the osteoblast in rheumatic diseases. Curr Osteoporos Rep. 2014 Mar; 12(1):9-16. PMID: 24363057.
    Citations:    
  36. Kay J, Morgacheva O, Messing SP, Kremer JM, Greenberg JD, Reed GW, Gravallese EM, Furst DE. Clinical disease activity and acute phase reactant levels are discordant among patients with active rheumatoid arthritis: acute phase reactant levels contribute separately to predicting outcome at one year. Arthritis Res Ther. 2014 Feb 03; 16(1):R40. PMID: 24485007.
    Citations: 19     Fields:    Translation:Humans
  37. Dusad A, Duryee MJ, Shaw AT, Klassen LW, Anderson DR, Wang D, Ren K, Gravallese EM, O'Dell JR, Mikuls TR, Thiele GM. Induction of bone loss in DBA/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant. Immunol Res. 2014 Jan; 58(1):51-60. PMID: 24371010.
    Citations:    
  38. Binks DA, Gravallese EM, Bergin D, Hodgson RJ, Tan AL, Matzelle MM, McGonagle D, Radjenovic A. Role of vascular channels as a novel mechanism for subchondral bone damage at cruciate ligament entheses in osteoarthritis and inflammatory arthritis. Ann Rheum Dis. 2015 Jan; 74(1):196-203. PMID: 24095939.
    Citations:    
  39. Walsh NC, Alexander KA, Manning CA, Karmakar S, Karmakar SK, Wang JF, Weyand CM, Pettit AR, Gravallese EM. Activated human T cells express alternative mRNA transcripts encoding a secreted form of RANKL. Genes Immun. 2013 Jul-Aug; 14(5):336-45. PMID: 23698708.
    Citations:    
  40. Kay J, Gravallese EM. Rheumatoid arthritis: erosion defined: back to basics. Nat Rev Rheumatol. 2013 Jun; 9(6):323-4. PMID: 23609778.
    Citations:    
  41. Schett G, Gravallese E. Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol. 2012 Nov; 8(11):656-64. PMID: 23007741.
    Citations:    
  42. Matzelle MM, Gallant MA, Condon KW, Walsh NC, Manning CA, Stein GS, Lian JB, Burr DB, Gravallese EM. Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway. Arthritis Rheum. 2012 May; 64(5):1540-50. PMID: 22139865.
    Citations:    
  43. Gravallese EM, Walsh NC. Rheumatoid arthritis: Repair of erosion in RA--shifting the balance to formation. Nat Rev Rheumatol. 2011 Sep 20; 7(11):626-8. PMID: 21931342.
    Citations:    
  44. Salomon-Escoto KI, Gravallese EM, Kay J. Assessment of control of rheumatoid arthritis disease activity. Best Pract Res Clin Rheumatol. 2011 Aug; 25(4):497-507. PMID: 22137920.
    Citations:    
  45. Karmakar S, Kay J, Gravallese EM. Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention. Rheum Dis Clin North Am. 2010 May; 36(2):385-404. PMID: 20510240.
    Citations:    
  46. Walsh NC, Gravallese EM. Bone remodeling in rheumatic disease: a question of balance. Immunol Rev. 2010 Jan; 233(1):301-12. PMID: 20193007.
    Citations:    
  47. Desai SP, Gravallese EM, Shadick NA, Glass R, Cui J, Frits M, Chibnik LB, Maher N, Weinblatt ME, Solomon DH. Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA. Rheumatology (Oxford). 2010 Mar; 49(3):513-9. PMID: 20026562.
    Citations: 6     Fields:    Translation:Humans
  48. Walsh NC, Reinwald S, Manning CA, Condon KW, Iwata K, Burr DB, Gravallese EM. Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis. J Bone Miner Res. 2009 Sep; 24(9):1572-85. PMID: 19338457.
    Citations:    
  49. Colbert RA, Deodhar AA, Fox D, Gravallese EM, Khan MA, McGonagle D, Reveille JD, Schett G, Weisman M, Clegg DO. Entheses and bones in spondyloarthritis: 2008 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN). J Rheumatol. 2009 Jul; 36(7):1527-31. PMID: 19567633.
    Citations:    
  50. Solomon DH, Finkelstein JS, Shadick N, LeBoff MS, Winalski CS, Stedman M, Glass R, Brookhart MA, Weinblatt ME, Gravallese EM. The relationship between focal erosions and generalized osteoporosis in postmenopausal women with rheumatoid arthritis. Arthritis Rheum. 2009 Jun; 60(6):1624-31. PMID: 19479876.
    Citations: 12     Fields:    Translation:Humans
  51. Shen Z, Crotti TN, McHugh KP, Matsuzaki K, Gravallese EM, Bierbaum BE, Goldring SR. The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis. Arthritis Res Ther. 2006; 8(3):R70. PMID: 16613614.
    Citations: 16     Fields:    Translation:HumansCells
  52. Pettit AR, Walsh NC, Manning C, Goldring SR, Gravallese EM. RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis. Rheumatology (Oxford). 2006 Sep; 45(9):1068-76. PMID: 16490750.
    Citations:    
  53. Walsh NC, Crotti TN, Goldring SR, Gravallese EM. Rheumatic diseases: the effects of inflammation on bone. Immunol Rev. 2005 Dec; 208:228-51. PMID: 16313352.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  54. Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese EM, Oettgen P, Libermann TA, Goldring MB. A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem. 2005 Nov 18; 280(46):38544-55. PMID: 16144844.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  55. Grall FT, Prall WC, Wei W, Gu X, Cho JY, Choy BK, Zerbini LF, Inan MS, Goldring SR, Gravallese EM, Goldring MB, Oettgen P, Libermann TA. The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. FEBS J. 2005 Apr; 272(7):1676-87. PMID: 15794755.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  56. Jacobs JP, Pettit AR, Shinohara ML, Jansson M, Cantor H, Gravallese EM, Mathis D, Benoist C. Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Arthritis Rheum. 2004 Aug; 50(8):2685-94. PMID: 15334485.
    Citations: 8     Fields:    Translation:AnimalsCells
  57. Goldring SR, Gravallese EM. Bisphosphonates: environmental protection for the joint? Arthritis Rheum. 2004 Jul; 50(7):2044-7. PMID: 15248201.
    Citations: 9     Fields:    Translation:AnimalsCells
  58. Walsh NC, Gravallese EM. Bone loss in inflammatory arthritis: mechanisms and treatment strategies. Curr Opin Rheumatol. 2004 Jul; 16(4):419-27. PMID: 15201606.
    Citations:    
  59. Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravallese EM, Oettgen P. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J Biol Chem. 2004 Mar 26; 279(13):12794-803. PMID: 14715662.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  60. Gravallese EM. Osteopontin: a bridge between bone and the immune system. J Clin Invest. 2003 Jul; 112(2):147-9. PMID: 12865402.
    Citations:    
  61. Grall F, Gu X, Tan L, Cho JY, Inan MS, Pettit AR, Thamrongsak U, Choy BK, Manning C, Akbarali Y, Zerbini L, Rudders S, Goldring SR, Gravallese EM, Oettgen P, Goldring MB, Libermann TA. Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1. Arthritis Rheum. 2003 May; 48(5):1249-60. PMID: 12746898.
    Citations: 29     Fields:    Translation:HumansCells
  62. Pisetsky DS, Hunder GG, Gravallese EM. New policy on disclosure of interest for American College of Rheumatology Journals. Arthritis Rheum. 2003 Apr 15; 49(2):149-50. PMID: 12687503.
    Citations:    
  63. Pisetsky DS, Hunder GG, Gravallese EM. New policy on disclosure of interest for American College of Rheumatology journals. Arthritis Rheum. 2003 Apr; 48(4):873-5. PMID: 12687527.
    Citations:    
  64. Gravallese EM, Pettit AR, Lee R, Madore R, Manning C, Tsay A, Gaspar J, Goldring MB, Goldring SR, Oettgen P. Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha. Ann Rheum Dis. 2003 Feb; 62(2):100-7. PMID: 12525377.
    Citations: 28     Fields:    Translation:HumansCells
  65. Lubberts E, Oppers-Walgreen B, Pettit AR, Van Den Bersselaar L, Joosten LA, Goldring SR, Gravallese EM, Van Den Berg WB. Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis. Arthritis Rheum. 2002 Nov; 46(11):3055-64. PMID: 12428250.
    Citations: 14     Fields:    Translation:AnimalsCells
  66. Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, Gravallese E, Mathis D, Benoist C. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med. 2002 Jul 01; 196(1):77-85. PMID: 12093872.
    Citations: 117     Fields:    Translation:Animals
  67. Goldring SR, Gravallese EM. Pathogenesis of bone lesions in rheumatoid arthritis. Curr Rheumatol Rep. 2002 Jun; 4(3):226-31. PMID: 12010607.
    Citations: 13     Fields:    Translation:HumansCells
  68. Husni ME, Maier AL, Mease PJ, Overman SS, Fraser P, Gravallese EM, Weinblatt ME. Etanercept in the treatment of adult patients with Still's disease. Arthritis Rheum. 2002 May; 46(5):1171-6. PMID: 12115220.
    Citations: 35     Fields:    Translation:HumansCTClinical Trials
  69. Hou WS, Li W, Keyszer G, Weber E, Levy R, Klein MJ, Gravallese EM, Goldring SR, Brömme D. Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 2002 Mar; 46(3):663-74. PMID: 11920402.
    Citations: 41     Fields:    Translation:HumansCells
  70. Raffel GD, Gravallese EM, Schwab P, Joseph JT, Cannistra SA. Diagnostic dilemmas in oncology: case 2. Dermatomyositis and ovarian cancer. J Clin Oncol. 2001 Dec 01; 19(23):4341-3. PMID: 11731518.
    Citations: 2     Fields:    Translation:Humans
  71. Pettit AR, Ji H, von Stechow D, Müller R, Goldring SR, Choi Y, Benoist C, Gravallese EM. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol. 2001 Nov; 159(5):1689-99. PMID: 11696430.
    Citations: 161     Fields:    Translation:Animals
  72. Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001 Jul 19; 412(6844):300-7. PMID: 11460154.
    Citations: 389     Fields:    Translation:AnimalsCells
  73. Gravallese EM, Galson DL, Goldring SR, Auron PE. The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption. Arthritis Res. 2001; 3(1):6-12. PMID: 11178122.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  74. Gravallese EM, Goldring SR. Cellular mechanisms and the role of cytokines in bone erosions in rheumatoid arthritis. Arthritis Rheum. 2000 Oct; 43(10):2143-51. PMID: 11037873.
    Citations: 42     Fields:    Translation:Humans
  75. Goldring SR, Gravallese EM. Pathogenesis of bone erosions in rheumatoid arthritis. Curr Opin Rheumatol. 2000 May; 12(3):195-9. PMID: 10803748.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  76. Mandl LA, Folkerth RD, Pick MA, Weinblatt ME, Gravallese EM. Amyloid myopathy masquerading as polymyositis. J Rheumatol. 2000 Apr; 27(4):949-52. PMID: 10782821.
    Citations: 7     Fields:    Translation:HumansCells
  77. Gravallese EM, Manning C, Tsay A, Naito A, Pan C, Amento E, Goldring SR. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum. 2000 Feb; 43(2):250-8. PMID: 10693863.
    Citations: 170     Fields:    Translation:HumansCells
  78. Ranger AM, Gerstenfeld LC, Wang J, Kon T, Bae H, Gravallese EM, Glimcher MJ, Glimcher LH. The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis. J Exp Med. 2000 Jan 03; 191(1):9-22. PMID: 10620601.
    Citations: 56     Fields:    Translation:AnimalsCells
  79. Goldring SR, Gravallese EM. Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications. Arthritis Res. 2000; 2(1):33-7. PMID: 11094416.
    Citations: 43     Fields:    Translation:Humans
  80. Gravallese EM, Harada Y, Wang JT, Gorn AH, Thornhill TS, Goldring SR. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol. 1998 Apr; 152(4):943-51. PMID: 9546355.
    Citations: 123     Fields:    Translation:HumansCells
  81. Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH. The transcription factor NF-ATc is essential for cardiac valve formation. Nature. 1998 Mar 12; 392(6672):186-90. PMID: 9515964.
    Citations: 160     Fields:    Translation:AnimalsCells
  82. Kelleher Doyle M, Telford SR, Criscione L, Lin SR, Spielman A, Gravallese EM. Cytokines in murine lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain. J Infect Dis. 1998 Jan; 177(1):242-6. PMID: 9419199.
    Citations:    
  83. Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 1998 Jan; 8(1):125-34. PMID: 9462518.
    Citations: 68     Fields:    Translation:AnimalsCells
  84. Darling JM, Goldring SR, Harada Y, Handel ML, Glowacki J, Gravallese EM. Multinucleated cells in pigmented villonodular synovitis and giant cell tumor of tendon sheath express features of osteoclasts. Am J Pathol. 1997 Apr; 150(4):1383-93. PMID: 9094994.
    Citations: 10     Fields:    Translation:HumansCells
  85. Ruderman EM, Crawford JM, Maier A, Liu JJ, Gravallese EM, Weinblatt ME. Histologic liver abnormalities in an autopsy series of patients with rheumatoid arthritis. Br J Rheumatol. 1997 Feb; 36(2):210-3. PMID: 9133932.
    Citations: 11     Fields:    Translation:Humans
  86. Gravallese EM, Handel ML, Coblyn J, Anderson RJ, Sperling RI, Karlson EW, Maier A, Ruderman EM, Formelli F, Weinblatt ME. N-[4-hydroxyphenyl] retinamide in rheumatoid arthritis: a pilot study. Arthritis Rheum. 1996 Jun; 39(6):1021-6. PMID: 8651965.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  87. Handel ML, McMorrow LB, Gravallese EM. Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum. 1995 Dec; 38(12):1762-70. PMID: 8849348.
    Citations:    
  88. Gravallese EM, Weissman BN, Brodsky G, Maguire J. Loosening of a revision total hip replacement in a 60-year-old woman with longstanding rheumatoid arthritis. Arthritis Rheum. 1995 Sep; 38(9):1315-24. PMID: 7575727.
    Citations: 1     Fields:    Translation:Humans
  89. Gravallese EM, Waksmonski C, Winters GL, Simms RW. Fever, arthralgias, skin lesions, and ischemic digits in a 59-year-old man. Arthritis Rheum. 1995 Aug; 38(8):1161-8. PMID: 7639815.
    Citations: 2     Fields:    Translation:Humans
  90. Ruderman EM, Kerr JS, Telford SR, Spielman A, Glimcher LH, Gravallese EM. Early murine Lyme carditis has a macrophage predominance and is independent of major histocompatibility complex class II-CD4+ T cell interactions. J Infect Dis. 1995 Feb; 171(2):362-70. PMID: 7844373.
    Citations: 23     Fields:    Translation:AnimalsCells
  91. Ruderman EM, Weinblatt ME, Thurmond LM, Pinkus GS, Gravallese EM. Synovial tissue response to treatment with Campath-1H. Arthritis Rheum. 1995 Feb; 38(2):254-8. PMID: 7531440.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
  92. Darling JM, Glimcher LH, Shortkroff S, Albano B, Gravallese EM. Expression of metalloproteinases in pigmented villonodular synovitis. Hum Pathol. 1994 Aug; 25(8):825-30. PMID: 8056425.
    Citations: 4     Fields:    Translation:Humans
  93. Gravallese EM, Winalski CS, Longtine J, Helfgott SM. Polyarthritis in a 78-year-old woman. Arthritis Rheum. 1994 Jul; 37(7):1087-95. PMID: 8024617.
    Citations:    Fields:    Translation:Humans
  94. Clauss IM, Gravallese EM, Darling JM, Shapiro F, Glimcher MJ, Glimcher LH. In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun; 197(2):146-56. PMID: 7693055.
    Citations: 22     Fields:    Translation:AnimalsCells
  95. Gravallese EM, Weissman BN, Corson JM, Greene JM. Synovitis of the knee in a 42-year-old man. Arthritis Rheum. 1993 Jun; 36(6):860-70. PMID: 8507229.
    Citations:    Fields:    Translation:Humans
  96. Gravallese EM, Baker N, Lester S, Kay J, Owen WF. Musculoskeletal manifestations in beta 2-microglobulin amyloidosis. Case discussion. Arthritis Rheum. 1992 May; 35(5):592-602. PMID: 1575795.
    Citations: 3     Fields:    Translation:Humans
  97. Gravallese EM, Darling JM, Glimcher LH, Boothby M. Role of lipopolysaccharide and IL-4 in control of transcription of the class II A alpha gene. J Immunol. 1991 Oct 01; 147(7):2377-83. PMID: 1918969.
    Citations: 2     Fields:    Translation:AnimalsCells
  98. Gravallese EM, Darling JM, Ladd AL, Katz JN, Glimcher LH. In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium. Arthritis Rheum. 1991 Sep; 34(9):1076-84. PMID: 1657007.
    Citations: 38     Fields:    Translation:HumansCells
  99. Gravallese EM, Boothby MR, Smas CM, Glimcher LH. A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B. Mol Cell Biol. 1989 Aug; 9(8):3184-92. PMID: 2477682.
    Citations: 10     Fields:    Translation:AnimalsCells
  100. Gravallese EM, Corson JM, Coblyn JS, Pinkus GS, Weinblatt ME. Rheumatoid aortitis: a rarely recognized but clinically significant entity. Medicine (Baltimore). 1989 Mar; 68(2):95-106. PMID: 2921941.
    Citations: 14     Fields:    Translation:Humans
  101. Shmerling RH, Stern SH, Gravallese EM, Kantrowitz FG. Tophaceous deposition in the finger pads without gouty arthritis. Arch Intern Med. 1988 Aug; 148(8):1830-2. PMID: 3401106.
    Citations: 4     Fields:    Translation:Humans
  102. Gravallese EM, Kantrowitz FG. Arthritic manifestations of inflammatory bowel disease. Am J Gastroenterol. 1988 Jul; 83(7):703-9. PMID: 3289378.
    Citations:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.