Harvard Catalyst Profiles

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Lydia Lynch, Ph.D.

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Biography
awards and honors
2008 - 2010
UNESCO-L'Oreal International Women In Science
2009 - 2013
Marie Curie International Fellowship
2020
Dept. of Medicine Mentor Award
2021
Melville Hare Memorial Lecture
2022
ICIS Luminex John R Kettman Award for Excellence in Interferon and Cytokine Research
2015 - 2020
American Diabetes Association Junior Career Development Award

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AI134861 (LYNCH, LYDIA) Aug 15, 2018 - Jul 31, 2023
    NIH
    Immunometabolic and epigenetic effects of obesity on innate immune surveillance in cancer
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kane H, LaMarche NM, Ní Scannail Á, Garza AE, Koay HF, Azad AI, Kunkemoeller B, Stevens B, Brenner MB, Lynch L. Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells. Elife. 2022 12 02; 11. PMID: 36458691; PMCID: PMC9831610.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Varghese B, Lynch L, Vriend LE, Draganov D, Clark JM, Kissick HT, Varghese S, Sanda MG, Dranoff G, Arredouani MS, Balk SP, Exley MA. Invariant NKT cell-augmented GM-CSF-secreting tumor vaccine is effective in advanced prostate cancer model. Cancer Immunol Immunother. 2022 Dec; 71(12):2943-2955. PMID: 35523889.
    Citations:    Fields:    
  3. Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O'Shea D, Brennan D, Lynch L. Correction: Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. J Exp Med. 2022 Mar 07; 219(3). PMID: 35226044; PMCID: PMC8941668.
    Citations:    Fields:    
  4. Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O'Shea D, Brennan D, Lynch L. Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. J Exp Med. 2022 03 07; 219(3). PMID: 35103755; PMCID: PMC8932531.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET. Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. Cell Metab. 2022 01 04; 34(1):140-157.e8. PMID: 34861155; PMCID: PMC8732317.
    Citations: 4     Fields:    Translation:Animals
  6. Lopes N, McIntyre C, Martin S, Raverdeau M, Sumaria N, Kohlgruber AC, Fiala GJ, Agudelo LZ, Dyck L, Kane H, Douglas A, Cunningham S, Prendeville H, Loftus R, Carmody C, Pierre P, Kellis M, Brenner M, Argüello RJ, Silva-Santos B, Pennington DJ, Lynch L. Distinct metabolic programs established in the thymus control effector functions of ?d T cell subsets in tumor microenvironments. Nat Immunol. 2021 02; 22(2):179-192. PMID: 33462452; PMCID: PMC7610600.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  7. Wara AK, Wang S, Wu C, Fang F, Haemmig S, Weber BN, Aydogan CO, Tesmenitsky Y, Aliakbarian H, Hawse JR, Subramaniam M, Zhao L, Sage PT, Tavakkoli A, Garza A, Lynch L, Banks AS, Feinberg MW. KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver. Cell Rep. 2020 12 29; 33(13):108550. PMID: 33378664.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB. Distinct iNKT Cell Populations Use IFN? or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis. Cell Metab. 2020 08 04; 32(2):243-258.e6. PMID: 32516575.
    Citations: 18     Fields:    Translation:AnimalsCells
  9. Clancy-Thompson E, Chen GZ, LaMarche NM, Ali LR, Jeong HJ, Crowley SJ, Boelaars K, Brenner MB, Lynch L, Dougan SK. Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1. EMBO J. 2019 07 15; 38(14):e101260. PMID: 31304630; PMCID: PMC6627243.
    Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
  10. Clancy-Thompson E, Chen GZ, LaMarche NM, Ali LR, Jeong HJ, Crowley SJ, Boelaars K, Brenner MB, Lynch L, Dougan SK. Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1. EMBO J. 2019 May 31. PMID: 31152007.
    Citations:    
  11. O'Brien A, Loftus RM, Pisarska MM, Tobin LM, Bergin R, Wood NAW, Foley C, Mat A, Tinley FC, Bannan C, Sommerville G, Veerapen N, Besra GS, Sinclair LV, Moynagh PN, Lynch L, Finlay DK, O'Shea D, Hogan AE. Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses. J Immunol. 2019 06 15; 202(12):3404-3411. PMID: 31076528.
    Citations: 21     Fields:    Translation:HumansCells
  12. Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L. Author Correction: ?d T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nat Immunol. 2019 Mar; 20(3):373. PMID: 30728493.
    Citations:    Fields:    
  13. Michelet X, Dyck L, Hogan A, Loftus RM, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O'Shea D, Nikolajczyk BS, Mills KHG, Brenner MB, Finlay D, Lynch L. Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nat Immunol. 2018 12; 19(12):1330-1340. PMID: 30420624.
    Citations: 169     Fields:    Translation:HumansAnimalsCells
  14. Wu D, Hu D, Chen H, Shi G, Fetahu IS, Wu F, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Yin C, Lian CG, Murphy GF, Adler GK, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi YG. Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer. Nature. 2018 07; 559(7715):637-641. PMID: 30022161.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  15. Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L. ?d T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nat Immunol. 2018 05; 19(5):464-474. PMID: 29670241.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  16. Hong S, Song W, Zushin PH, Liu B, Jedrychowski MP, Mina AI, Deng Z, Cabarkapa D, Hall JA, Palmer CJ, Aliakbarian H, Szpyt J, Gygi SP, Tavakkoli A, Lynch L, Perrimon N, Banks AS. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab. 2018 06; 12:25-38. PMID: 29661693.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  17. LaMarche NM, Lynch L. Adipose Dendritic Cells Come Out of Hiding. Cell Metab. 2018 03 06; 27(3):485-486. PMID: 29514060.
    Citations: 2     Fields:    Translation:Cells
  18. Prüss H, Tedeschi A, Thiriot A, Lynch L, Loughhead SM, Stutte S, Mazo IB, Kopp MA, Brommer B, Blex C, Geurtz LC, Liebscher T, Niedeggen A, Dirnagl U, Bradke F, Volz MS, DeVivo MJ, Chen Y, von Andrian UH, Schwab JM. Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex. Nat Neurosci. 2017 Nov; 20(11):1549-1559. PMID: 28920935.
    Citations: 53     Fields:    Translation:HumansAnimals
  19. Chang SK, Kohlgruber AC, Mizoguchi F, Michelet X, Wolf BJ, Wei K, Lee PY, Lynch L, Duquette D, Ceperuelo-Mallafré V, Banks AS, Brenner MB. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. J Clin Invest. 2017 Sep 01; 127(9):3300-3312. PMID: 28758901; PMCID: PMC5669565.
    Citations: 26     Fields:    Translation:AnimalsCells
  20. Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan AE, Dold C, O'Connor D, Stutte S, Tavakkoli A, Winters D, Exley MA, O'Shea D, Brenner MB, von Andrian U, Lynch L. Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity. Immunity. 2017 02 21; 46(2):273-286. PMID: 28228283.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  21. Kohlgruber AC, LaMarche NM, Lynch L. Adipose tissue at the nexus of systemic and cellular immunometabolism. Semin Immunol. 2016 10; 28(5):431-440. PMID: 27789087.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  22. Lynch L, Hogan AE, Duquette D, Lester C, Banks A, LeClair K, Cohen DE, Ghosh A, Lu B, Corrigan M, Stevanovic D, Maratos-Flier E, Drucker DJ, O'Shea D, Brenner M. iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Cell Metab. 2016 09 13; 24(3):510-519. PMID: 27593966; PMCID: PMC5061124.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  23. Longchamp A, Tao M, Bartelt A, Ding K, Lynch L, Hine C, Corpataux JM, Kristal BS, Mitchell JR, Ozaki CK. Surgical injury induces local and distant adipose tissue browning. Adipocyte. 2016 Apr-Jun; 5(2):163-74. PMID: 27386152.
    Citations: 9     Fields:    
  24. Kohlgruber A, Lynch L. Adipose tissue inflammation in the pathogenesis of type 2 diabetes. Curr Diab Rep. 2015 Nov; 15(11):92. PMID: 26374569.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  25. Carolan E, Tobin LM, Mangan BA, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter DC, Doherty DG, Lynch L, O'Shea D, Hogan AE. Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity. J Immunol. 2015 Jun 15; 194(12):5775-80. PMID: 25980010.
    Citations: 64     Fields:    Translation:HumansCells
  26. Kim EY, Lynch L, Brennan PJ, Cohen NR, Brenner MB. The transcriptional programs of iNKT cells. Semin Immunol. 2015 Feb; 27(1):26-32. PMID: 25841627; PMCID: PMC6322908.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  27. Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant'Angelo DB, von Andrian U, Brenner MB. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol. 2015 Jan; 16(1):85-95. PMID: 25436972; PMCID: PMC4343194.
    Citations: 183     Fields:    Translation:AnimalsCells
  28. Exley MA, Hand L, O'Shea D, Lynch L. Interplay between the immune system and adipose tissue in obesity. J Endocrinol. 2014 Nov; 223(2):R41-8. PMID: 25228503.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  29. Lynch L. Adipose invariant natural killer T cells. Immunology. 2014 Jul; 142(3):337-46. PMID: 24673647.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  30. Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O'Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O'Farrelly C, Allan SM, Roche HM, O'Shea DB, Lavelle EC. Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1a-dependent inflammation. Diabetes. 2014 Jun; 63(6):2037-50. PMID: 24458363.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  31. Hogan AE, Gaoatswe G, Lynch L, Corrigan MA, Woods C, O'Connell J, O'Shea D. Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Diabetologia. 2014 Apr; 57(4):781-4. PMID: 24362727.
    Citations: 56     Fields:    Translation:Humans
  32. Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity. 2012 Sep 21; 37(3):574-87. PMID: 22981538.
    Citations: 241     Fields:    Translation:HumansAnimalsCells
  33. Szereday L, Miko E, Meggyes M, Barakonyi A, Farkas B, Varnagy A, Bodis J, Lynch L, O'Farrelly C, Szekeres-Bartho J. Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy. Am J Reprod Immunol. 2012 Jan; 67(1):9-16. PMID: 21682790.
    Citations: 7     Fields:    Translation:HumansCells
  34. Exley MA, Lynch L, Varghese B, Nowak M, Alatrakchi N, Balk SP. Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects. Clin Immunol. 2011 Aug; 140(2):184-95. PMID: 21646050.
    Citations: 25     Fields:    Translation:HumansCells
  35. Hogan AE, Corrigan MA, O'Reilly V, Gaoatswe G, O'Connell J, Doherty DG, Lynch L, O'Shea D. Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Clin Immunol. 2011 Sep; 140(3):229-35. PMID: 21684213.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  36. O'Connell J, Lynch L, Cawood TJ, Kwasnik A, Nolan N, Geoghegan J, McCormick A, O'Farrelly C, O'Shea D. The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. PLoS One. 2010 Apr 01; 5(4):e9997. PMID: 20376319.
    Citations: 77     Fields:    Translation:HumansCells
  37. O'Donovan A, Hughes BM, Slavich GM, Lynch L, Cronin MT, O'Farrelly C, Malone KM. Clinical anxiety, cortisol and interleukin-6: evidence for specificity in emotion-biology relationships. Brain Behav Immun. 2010 Oct; 24(7):1074-7. PMID: 20227485; PMCID: PMC4361085.
    Citations: 100     Fields:    Translation:Humans
  38. Nowak M, Lynch L, Yue S, Ohta A, Sitkovsky M, Balk SP, Exley MA. The A2aR adenosine receptor controls cytokine production in iNKT cells. Eur J Immunol. 2010 Mar; 40(3):682-7. PMID: 20039304.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  39. O'Shea D, Cawood TJ, O'Farrelly C, Lynch L. Natural killer cells in obesity: impaired function and increased susceptibility to the effects of cigarette smoke. PLoS One. 2010 Jan 25; 5(1):e8660. PMID: 20107494.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  40. Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C. Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity. Eur J Immunol. 2009 Jul; 39(7):1893-901. PMID: 19585513.
    Citations: 123     Fields:    Translation:HumansCells
  41. McGrath E, Ryan EJ, Lynch L, Golden-Mason L, Mooney E, Eogan M, O'Herlihy C, O'Farrelly C. Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility. Am J Reprod Immunol. 2009 Apr; 61(4):265-76. PMID: 19260857.
    Citations: 8     Fields:    Translation:HumansCells
  42. Lynch LA, O'Connell JM, Kwasnik AK, Cawood TJ, O'Farrelly C, O'Shea DB. Are natural killer cells protecting the metabolically healthy obese patient? Obesity (Silver Spring). 2009 Mar; 17(3):601-5. PMID: 19238145.
    Citations: 93     Fields:    Translation:HumansCells
  43. Lynch L, O'Donoghue D, Dean J, O'Sullivan J, O'Farrelly C, Golden-Mason L. Detection and characterization of hemopoietic stem cells in the adult human small intestine. J Immunol. 2006 May 01; 176(9):5199-204. PMID: 16621984.
    Citations: 13     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.