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Tun-hou Lee, S.D.

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Biography
National Taiwan UniversityB.P.H1976
Harvard School of Public HealthS.M.1978
Harvard School of Public HealthD.Sc.1982

Overview
Research

Professor Lee's major research interests are virus-specific antigens and their association with disease manifestations, viral replication, and host-virus interactions, with particular focus on human and related primate retroviruses.

Currently, Professor Lee is focusing on the modification of the antigenicity of HIV envelope protein for vaccine development. His work has contributed to the development of serologic testing for the human leukemia virus (HTLV-I) and HIV. He was the first to identify the envelope gene products of HTLV-I, HTLV-II and HIV, and demonstrated that the envelope antibody is the most important marker for screening individuals for infection with the human retroviruses. This information became the basis for serologic tests for blood bank screening. He also identified the putative transforming protein of HTLV-I, which was also the first observation of a retrovirus protein linked to a cancer that was not an oncogene product.

Professor Lee has also worked to identify the immune response to HIV envelope protein and outcome of human immunodeficiency virus infection. His work on HIV envelope protein revealed that an association exists between progress to AIDS and the lack of certain envelope antibodies. Professor Lee has been a recipient of the junior investigator award from the Leukemia Society of America and the Swedish Medical Research Council postdoctoral fellowship award.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Armstrong KL, Lee TH, Essex M. Replicative fitness costs of nonnucleoside reverse transcriptase inhibitor drug resistance mutations on HIV subtype C. Antimicrob Agents Chemother. 2011 May; 55(5):2146-53. PMID: 21402856.
    Citations: 9     Fields:    Translation:HumansCells
  2. Teeravechyan S, Essex M, Lee TH. Conserved determinants of enhanced CCR5 binding in the human immunodeficiency virus subtype D envelope third variable loop. AIDS Res Hum Retroviruses. 2010 Apr; 26(4):481-8. PMID: 20377425.
    Citations:    Fields:    Translation:HumansCells
  3. Armstrong KL, Lee TH, Essex M. Replicative capacity differences of thymidine analog resistance mutations in subtype B and C human immunodeficiency virus type 1. J Virol. 2009 May; 83(9):4051-9. PMID: 19225005.
    Citations: 8     Fields:    Translation:HumansCells
  4. Chigwedere P, Seage GR, Gruskin S, Lee TH, Essex M. Estimating the lost benefits of antiretroviral drug use in South Africa. . 2008 Dec 01; 49(4):410-5. PMID: 19186354.
    Citations: 44     Translation:Humans
  5. Chigwedere P, Seage GR, Lee TH, Essex M. Efficacy of antiretroviral drugs in reducing mother-to-child transmission of HIV in Africa: a meta-analysis of published clinical trials. AIDS Res Hum Retroviruses. 2008 Jun; 24(6):827-37. PMID: 18544018.
    Citations: 16     Fields:    Translation:HumansCells
  6. Teeravechyan S, Suphaphiphat P, Essex M, Lee TH. Relative concordance of human immunodeficiency virus oligomeric and monomeric envelope in CCR5 coreceptor usage. Virology. 2008 Jan 20; 370(2):443-50. PMID: 17936869.
    Citations: 1     Fields:    Translation:HumansCells
  7. Suphaphiphat P, Essex M, Lee TH. Mutations in the V3 stem versus the V3 crown and C4 region have different effects on the binding and fusion steps of human immunodeficiency virus type 1 gp120 interaction with the CCR5 coreceptor. Virology. 2007 Mar 30; 360(1):182-90. PMID: 17101166.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  8. Thior I, Lockman S, Smeaton LM, Shapiro RL, Wester C, Heymann SJ, Gilbert PB, Stevens L, Peter T, Kim S, van Widenfelt E, Moffat C, Ndase P, Arimi P, Kebaabetswe P, Mazonde P, Makhema J, McIntosh K, Novitsky V, Lee TH, Marlink R, Lagakos S, Essex M. Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study. JAMA. 2006 Aug 16; 296(7):794-805. PMID: 16905785.
    Citations: 147     Fields:    Translation:HumansCells
  9. Da'Dara AA, Lautsch N, Dudek T, Novitsky V, Lee TH, Essex M, Harn DA. Helminth infection suppresses T-cell immune response to HIV-DNA-based vaccine in mice. Vaccine. 2006 Jun 12; 24(24):5211-9. PMID: 16675073.
    Citations: 15     Fields:    Translation:AnimalsCells
  10. Novitsky VA, Gilbert PB, Shea K, McLane MF, Rybak N, Klein I, Thior I, Ndung'u T, Lee TH, Essex ME. Interactive association of proviral load and IFN-gamma-secreting T cell responses in HIV-1C infection. Virology. 2006 May 25; 349(1):142-55. PMID: 16519915.
    Citations: 12     Fields:    Translation:HumansCells
  11. Montano M, Russell M, Gilbert P, Thior I, Lockman S, Shapiro R, Chang SY, Lee TH, Essex M. Comparative prediction of perinatal human immunodeficiency virus type 1 transmission, using multiple virus load markers. J Infect Dis. 2003 Aug 01; 188(3):406-13. PMID: 12870122.
    Citations: 11     Fields:    Translation:HumansCells
  12. Suphaphiphat P, Thitithanyanont A, Paca-Uccaralertkun S, Essex M, Lee TH. Effect of amino acid substitution of the V3 and bridging sheet residues in human immunodeficiency virus type 1 subtype C gp120 on CCR5 utilization. J Virol. 2003 Mar; 77(6):3832-7. PMID: 12610158.
    Citations: 13     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.