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Benjamin Elison Gewurz, M.D.,Ph.D.

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Biography
2012 - 2017
Burroughs Wellcome Career Award in Medical Sciences
2012 - 2013
Fellow, Karin Grunebaum Cancer Research Foundation
2010
Maxwell Finland Award For Excellence in Research
2008
Scott James Thaler Award
2008
Brigham Research Institue (BRI) Research Excellence Award
2007 - 2010
Fellow, Leukemia & Lymphoma Society
2006
Edward Kass Award for Excellence in Clinical Medicine
2001
Jeffrey Modell Prize
2000
American Academy of Achievement Award
2000
Derek Bok Award for Excellence in Undergraduate Teaching
1997 - 2001
Howard Hughes Predoctoral Fellowship
1995
Phi Beta Kappa
1995
Firestone Medal for Excellence in Undergraduate Research

Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI137337 (GEWURZ, BENJAMIN ELISON) Mar 15, 2018 - Mar 31, 2023
    NIH/NIAID
    Metabolic Network Remodeling in Epstein-Barr Virus Lymphomagenesis
    Role: Principal Investigator
  2. (Benjamin Gewurz) Sep 1, 2012 - Jan 1, 2021
    Burroughs Wellcome Foundation Career Award in Medical Sciences
    Role Description: Career Award in Medical Sciences
    Role: PI
  3. K08CA140780 (GEWURZ, BENJAMIN ELISON) Jul 1, 2010 - Jun 30, 2015
    NIH/NCI
    Genetic and Proteomic Analysis of Epstein-Barr Virus LMP1 Activation of NF-kB
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang LW, Shen H, Nobre L, Ersing I, Paulo JA, Trudeau S, Wang Z, Smith NA, Ma Y, Reinstadler B, Nomburg J, Sommermann T, Cahir-McFarland E, Gygi SP, Mootha VK, Weekes MP, Gewurz BE. Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation. Cell Metab. 2019 Jun 25. PMID: 31257153.
    Citations:    
  2. Wang C, Li D, Zhang L, Jiang S, Liang J, Narita Y, Hou I, Zhong Q, Zheng Z, Xiao H, Gewurz BE, Teng M, Zhao B. RNA Sequencing Analyses of Gene Expression during Epstein-Barr Virus Infection of Primary B Lymphocytes. J Virol. 2019 Jul 01; 93(13). PMID: 31019051.
    Citations:    
  3. Wang C, Jiang S, Zhang L, Li D, Liang J, Narita Y, Hou I, Zhong Q, Gewurz BE, Teng M, Zhao B. TAF family proteins and MEF2C are essential for Epstein-Barr virus MYC super-enhancer activity. J Virol. 2019 Jun 05. PMID: 31167905.
    Citations:    
  4. Wang C, Jiang S, Ke L, Zhang L, Li D, Liang J, Narita Y, Hou I, Chen CH, Wang L, Zhong Q, Ling Y, Lv X, Xiang Y, Guo X, Teng M, Tsao SW, Gewurz BE, Zeng MS, Zhao B. Genome-wide CRISPR-based gene knockout screens reveal cellular factors and pathways essential for nasopharyngeal carcinoma. J Biol Chem. 2019 Jun 21; 294(25):9734-9745. PMID: 31073033.
    Citations:    
  5. Mitsialis V, Wu Y, Gewurz B, Bleday R, Doyle LA, Winter RW, Hamilton MJ. Raising the Barr: An Unexpected Lesion at Ileal-Cecal Resection. Dig Dis Sci. 2019 02; 64(2):353-357. PMID: 30535887.
    Citations:    Fields:    
  6. Frost TC, Gewurz BE. Epigenetic crossroads of the Epstein-Barr virus B-cell relationship. Curr Opin Virol. 2018 10; 32:15-23. PMID: 30227386.
    Citations:    Fields:    
  7. Zhang H, Li Y, Wang HB, Zhang A, Chen ML, Fang ZX, Dong XD, Li SB, Du Y, Xiong D, He JY, Li MZ, Liu YM, Zhou AJ, Zhong Q, Zeng YX, Kieff E, Zhang Z, Gewurz BE, Zhao B, Zeng MS. Author Correction: Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry. Nat Microbiol. 2018 Sep; 3(9):1075. PMID: 29679064.
    Citations:    Fields:    
  8. Wang C, Zhou H, Xue Y, Liang J, Narita Y, Gerdt C, Zheng AY, Jiang R, Trudeau S, Peng CW, Gewurz BE, Zhao B. Epstein-Barr Virus Nuclear Antigen Leader Protein Coactivates EP300. J Virol. 2018 05 01; 92(9). PMID: 29467311.
    Citations:    Fields:    Translation:HumansCells
  9. Gebre M, Nomburg JL, Gewurz BE. CRISPR-Cas9 Genetic Analysis of Virus-Host Interactions. Viruses. 2018 01 30; 10(2). PMID: 29385696.
    Citations:    Fields:    Translation:HumansCells
  10. Wang LW, Trudeau SJ, Wang C, Gerdt C, Jiang S, Zhao B, Gewurz BE. Modulating Gene Expression in Epstein-Barr Virus (EBV)-Positive B Cell Lines with CRISPRa and CRISPRi. Curr Protoc Mol Biol. 2018 01 16; 121:31.13.1-31.13.18. PMID: 29337370.
    Citations: 1     Fields:    
  11. Jiang S, Wang LW, Walsh MJ, Trudeau SJ, Gerdt C, Zhao B, Gewurz BE. CRISPR/Cas9-Mediated Genome Editing in Epstein-Barr Virus-Transformed Lymphoblastoid B-Cell Lines. Curr Protoc Mol Biol. 2018 01 16; 121:31.12.1-31.12.23. PMID: 29337376.
    Citations: 2     Fields:    
  12. Zhang H, Li Y, Wang HB, Zhang A, Chen ML, Fang ZX, Dong XD, Li SB, Du Y, Xiong D, He JY, Li MZ, Liu YM, Zhou AJ, Zhong Q, Zeng YX, Kieff E, Zhang Z, Gewurz BE, Zhao B, Zeng MS. Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry. Nat Microbiol. 2018 02; 3(2):1-8. PMID: 29292383.
    Citations: 6     Fields:    
  13. Wang LW, Jiang S, Gewurz BE. Epstein-Barr Virus LMP1-Mediated Oncogenicity. J Virol. 2017 11 01; 91(21). PMID: 28835489.
    Citations: 5     Fields:    Translation:HumansAnimals
  14. Jiang S, Zhou H, Liang J, Gerdt C, Wang C, Ke L, Schmidt SCS, Narita Y, Ma Y, Wang S, Colson T, Gewurz B, Li G, Kieff E, Zhao B. The Epstein-Barr Virus Regulome in Lymphoblastoid Cells. Cell Host Microbe. 2017 Oct 11; 22(4):561-573.e4. PMID: 29024646.
    Citations: 6     Fields:    Translation:HumansCells
  15. Ersing I, Nobre L, Wang LW, Soday L, Ma Y, Paulo JA, Narita Y, Ashbaugh CW, Jiang C, Grayson NE, Kieff E, Gygi SP, Weekes MP, Gewurz BE. A Temporal Proteomic Map of Epstein-Barr Virus Lytic Replication in B Cells. Cell Rep. 2017 05 16; 19(7):1479-1493. PMID: 28514666.
    Citations: 7     Fields:    Translation:HumansCells
  16. Ma Y, Walsh MJ, Bernhardt K, Ashbaugh CW, Trudeau SJ, Ashbaugh IY, Jiang S, Jiang C, Zhao B, Root DE, Doench JG, Gewurz BE. CRISPR/Cas9 Screens Reveal Epstein-Barr Virus-Transformed B Cell Host Dependency Factors. Cell Host Microbe. 2017 May 10; 21(5):580-591.e7. PMID: 28494239.
    Citations: 15     Fields:    Translation:HumansCells
  17. Minamitani T, Ma Y, Zhou H, Kida H, Tsai CY, Obana M, Okuzaki D, Fujio Y, Kumanogoh A, Zhao B, Kikutani H, Kieff E, Gewurz BE, Yasui T. Mouse model of Epstein-Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):4751-4756. PMID: 28351978.
    Citations: 11     Fields:    Translation:AnimalsCells
  18. Blondel CJ, Park JS, Hubbard TP, Pacheco AR, Kuehl CJ, Walsh MJ, Davis BM, Gewurz BE, Doench JG, Waldor MK. CRISPR/Cas9 Screens Reveal Requirements for Host Cell Sulfation and Fucosylation in Bacterial Type III Secretion System-Mediated Cytotoxicity. Cell Host Microbe. 2016 Aug 10; 20(2):226-37. PMID: 27453484.
    Citations: 10     Fields:    Translation:HumansCells
  19. Hunter JE, Butterworth JA, Zhao B, Sellier H, Campbell KJ, Thomas HD, Bacon CM, Cockell SJ, Gewurz BE, Perkins ND. The NF-?B subunit c-Rel regulates Bach2 tumour suppressor expression in B-cell lymphoma. Oncogene. 2016 06 30; 35(26):3476-84. PMID: 26522720.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  20. Minamitani T, Yasui T, Ma Y, Zhou H, Okuzaki D, Tsai CY, Sakakibara S, Gewurz BE, Kieff E, Kikutani H. Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A. Proc Natl Acad Sci U S A. 2015 Sep 15; 112(37):11612-7. PMID: 26305967.
    Citations: 11     Fields:    Translation:AnimalsCells
  21. Greenfeld H, Takasaki K, Walsh MJ, Ersing I, Bernhardt K, Ma Y, Fu B, Ashbaugh CW, Cabo J, Mollo SB, Zhou H, Li S, Gewurz BE. TRAF1 Coordinates Polyubiquitin Signaling to Enhance Epstein-Barr Virus LMP1-Mediated Growth and Survival Pathway Activation. PLoS Pathog. 2015 May; 11(5):e1004890. PMID: 25996949.
    Citations: 13     Fields:    Translation:HumansCells
  22. Zhou H, Schmidt SC, Jiang S, Willox B, Bernhardt K, Liang J, Johannsen EC, Kharchenko P, Gewurz BE, Kieff E, Zhao B. Epstein-Barr virus oncoprotein super-enhancers control B cell growth. Cell Host Microbe. 2015 Feb 11; 17(2):205-16. PMID: 25639793.
    Citations: 35     Fields:    Translation:Cells
  23. Iannetti A, Ledoux AC, Tudhope SJ, Sellier H, Zhao B, Mowla S, Moore A, Hummerich H, Gewurz BE, Cockell SJ, Jat PS, Willmore E, Perkins ND. Regulation of p53 and Rb links the alternative NF-?B pathway to EZH2 expression and cell senescence. PLoS Genet. 2014 Sep; 10(9):e1004642. PMID: 25255445.
    Citations: 22     Fields:    Translation:HumansCells
  24. Zhao B, Barrera LA, Ersing I, Willox B, Schmidt SC, Greenfeld H, Zhou H, Mollo SB, Shi TT, Takasaki K, Jiang S, Cahir-McFarland E, Kellis M, Bulyk ML, Kieff E, Gewurz BE. The NF-?B genomic landscape in lymphoblastoid B cells. Cell Rep. 2014 Sep 11; 8(5):1595-606. PMID: 25159142.
    Citations: 47     Fields:    Translation:HumansCells
  25. Zhou X, Massol RH, Nakamura F, Chen X, Gewurz BE, Davis BM, Lencer WI, Waldor MK. Remodeling of the intestinal brush border underlies adhesion and virulence of an enteric pathogen. MBio. 2014 Aug 19; 5(4). PMID: 25139905.
    Citations: 5     Fields:    Translation:AnimalsCells
  26. Ersing I, Bernhardt K, Gewurz BE. NF-?B and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1. Viruses. 2013 Jun 21; 5(6):1587-606. PMID: 23793113.
    Citations: 19     Fields:    Translation:HumansCells
  27. Zhou X, Gewurz BE, Ritchie JM, Takasaki K, Greenfeld H, Kieff E, Davis BM, Waldor MK. A Vibrio parahaemolyticus T3SS effector mediates pathogenesis by independently enabling intestinal colonization and inhibiting TAK1 activation. Cell Rep. 2013 May 30; 3(5):1690-702. PMID: 23623501.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  28. Gewurz BE, Towfic F, Mar JC, Shinners NP, Takasaki K, Zhao B, Cahir-McFarland ED, Quackenbush J, Xavier RJ, Kieff E. Genome-wide siRNA screen for mediators of NF-?B activation. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2467-72. PMID: 22308454.
    Citations: 31     Fields:    Translation:HumansCells
  29. Gewurz BE, Mar JC, Padi M, Zhao B, Shinners NP, Takasaki K, Bedoya E, Zou JY, Cahir-McFarland E, Quackenbush J, Kieff E. Canonical NF-kappaB activation is essential for Epstein-Barr virus latent membrane protein 1 TES2/CTAR2 gene regulation. J Virol. 2011 Jul; 85(13):6764-73. PMID: 21543491.
    Citations: 19     Fields:    Translation:HumansCells
  30. Zhao B, Mar JC, Maruo S, Lee S, Gewurz BE, Johannsen E, Holton K, Rubio R, Takada K, Quackenbush J, Kieff E. Epstein-Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell lines. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):337-42. PMID: 21173222.
    Citations: 21     Fields:    Translation:HumansCells
  31. Boehm D, Gewurz BE, Kieff E, Cahir-McFarland E. Epstein-Barr latent membrane protein 1 transformation site 2 activates NF-kappaB in the absence of NF-kappaB essential modifier residues 133-224 or 373-419. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18103-8. PMID: 20923877.
    Citations: 8     Fields:    Translation:HumansCells
  32. Song YJ, Izumi KM, Shinners NP, Gewurz BE, Kieff E. IRF7 activation by Epstein-Barr virus latent membrane protein 1 requires localization at activation sites and TRAF6, but not TRAF2 or TRAF3. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18448-53. PMID: 19017798.
    Citations: 17     Fields:    Translation:HumansCells
  33. Vannier E, Gewurz BE, Krause PJ. Human babesiosis. Infect Dis Clin North Am. 2008 Sep; 22(3):469-88, viii-ix. PMID: 18755385.
    Citations: 51     Fields:    Translation:HumansAnimals
  34. Gewurz BE, Marty FM, Baden LR, Katz JT. Human herpesvirus 6 encephalitis. Curr Infect Dis Rep. 2008 Jul; 10(4):292-9. PMID: 18765102.
    Citations: 5     
  35. Krause PJ, Gewurz BE, Hill D, Marty FM, Vannier E, Foppa IM, Furman RR, Neuhaus E, Skowron G, Gupta S, McCalla C, Pesanti EL, Young M, Heiman D, Hsue G, Gelfand JA, Wormser GP, Dickason J, Bia FJ, Hartman B, Telford SR, Christianson D, Dardick K, Coleman M, Girotto JE, Spielman A. Persistent and relapsing babesiosis in immunocompromised patients. Clin Infect Dis. 2008 Feb 01; 46(3):370-6. PMID: 18181735.
    Citations: 51     Fields:    Translation:HumansAnimals
  36. Gewurz BE, Harper JW. DNA-damage control: Claspin destruction turns off the checkpoint. Curr Biol. 2006 Nov 07; 16(21):R932-4. PMID: 17084694.
    Citations: 7     Fields:    Translation:AnimalsCells
  37. Gewurz BE, Dezube BJ, Pantanowitz L. HIV and the breast. AIDS Read. 2005 Aug; 15(8):392-6, 399-402. PMID: 16110554.
    Citations: 4     Fields:    Translation:Humans
  38. Gewurz BE, Jacobs M, Proper JA, Dahl TA, Fujiwara T, Dezube BJ. Capravirine, a nonnucleoside reverse-transcriptase inhibitor in patients infected with HIV-1: a phase 1 study. J Infect Dis. 2004 Dec 01; 190(11):1957-61. PMID: 15529260.
    Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
  39. Gewurz BE, Ploegh HL, Tortorella D. US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide. J Biol Chem. 2002 Mar 29; 277(13):11306-13. PMID: 11790769.
    Citations: 14     Fields:    Translation:HumansCells
  40. Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL. Virus subversion of immunity: a structural perspective. Curr Opin Immunol. 2001 Aug; 13(4):442-50. PMID: 11498300.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  41. Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL, Wiley DC. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proc Natl Acad Sci U S A. 2001 Jun 05; 98(12):6794-9. PMID: 11391001.
    Citations: 45     Fields:    Translation:HumansCells
  42. Gewurz BE, Wang EW, Tortorella D, Schust DJ, Ploegh HL. Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner. J Virol. 2001 Jun; 75(11):5197-204. PMID: 11333901.
    Citations: 31     Fields:    Translation:HumansCells
  43. McAdam AJ, Gewurz BE, Farkash EA, Sharpe AH. Either B7 costimulation or IL-2 can elicit generation of primary alloreactive CTL. J Immunol. 2000 Sep 15; 165(6):3088-93. PMID: 10975820.
    Citations: 5     Fields:    Translation:AnimalsCells
  44. Tortorella D, Gewurz B, Schust D, Furman M, Ploegh H. Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology. Immunol Invest. 2000 May; 29(2):97-100. PMID: 10854174.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  45. Tortorella D, Gewurz BE, Furman MH, Schust DJ, Ploegh HL. Viral subversion of the immune system. Annu Rev Immunol. 2000; 18:861-926. PMID: 10837078.
    Citations: 236     Fields:    Translation:HumansAnimalsCells
  46. McAdam AJ, Farkash EA, Gewurz BE, Sharpe AH. B7 costimulation is critical for antibody class switching and CD8(+) cytotoxic T-lymphocyte generation in the host response to vesicular stomatitis virus. J Virol. 2000 Jan; 74(1):203-8. PMID: 10590107.
    Citations: 33     Fields:    Translation:AnimalsCells
  47. Moxon ER, Gewurz BE, Richards JC, Inzana T, Jennings MP, Hood DW. Phenotypic switching of Haemophilus influenzae. Mol Microbiol. 1996 Mar; 19(5):1149-50. PMID: 8830271.
    Citations: 1     Fields:    Translation:Cells
  48. Ying SC, Marchalonis JJ, Gewurz AT, Siegel JN, Jiang H, Gewurz BE, Gewurz H. Reactivity of anti-human C-reactive protein (CRP) and serum amyloid P component (SAP) monoclonal antibodies with limulin and pentraxins of other species. Immunology. 1992 Jun; 76(2):324-30. PMID: 1378818.
    Citations: 3     Fields:    Translation:HumansAnimals
  49. Ying SC, Shephard E, de Beer FC, Siegel JN, Harris D, Gewurz BE, Fridkin M, Gewurz H. Localization of sequence-determined neoepitopes and neutrophil digestion fragments of C-reactive protein utilizing monoclonal antibodies and synthetic peptides. Mol Immunol. 1992 May; 29(5):677-87. PMID: 1374844.
    Citations: 5     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.