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Last Name

profileStephanie Mohr, PH.D.

TitleLecturer on Genetics
InstitutionHarvard Medical School
AddressHarvard Medical School
Dept of Genetics
77 Avenue Louis Pasteur
Boston MA 02115
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Drosophila RNAi Screening Center (HMS) - Core services (6), Instruments (6), Plasmids (3875), RNAi libraries (12) and Resource Collection (1)
Genome Engineering Production Group (HMS) - Core services (4) and Instruments (1)
DF/HCC Collaborative Functional Genomics Core - Core services (8) and Instruments (4)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Vinayagam A, Kulkarni MM, Sopko R, Sun X, Hu Y, Nand A, Villalta C, Moghimi A, Yang X, Mohr SE, Hong P, Asara JM, Perrimon N. An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling. Cell Rep. 2016 Sep 13; 16(11):3062-74. PMID: 27626673.
    View in: PubMed
  2. Mohr SE, Hu Y, Ewen-Campen B, Housden BE, Viswanatha R, Perrimon N. CRISPR guide RNA design for research applications. FEBS J. 2016 Sep; 283(17):3232-8. PMID: 27276584.
    View in: PubMed
  3. Housden BE, Valvezan AJ, Kelley C, Sopko R, Hu Y, Roesel C, Lin S, Buckner M, Tao R, Yilmazel B, Mohr SE, Manning BD, Perrimon N. Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi. Sci Signal. 2015 Sep 8; 8(393):rs9. PMID: 26350902; PMCID: PMC4642709 [Available on 03/08/16].
  4. Perkins LA, Holderbaum L, Tao R, Hu Y, Sopko R, McCall K, Yang-Zhou D, Flockhart I, Binari R, Shim HS, Miller A, Housden A, Foos M, Randkelv S, Kelley C, Namgyal P, Villalta C, Liu LP, Jiang X, Huan-Huan Q, Wang X, Fujiyama A, Toyoda A, Ayers K, Blum A, Czech B, Neumuller R, Yan D, Cavallaro A, Hibbard K, Hall D, Cooley L, Hannon GJ, Lehmann R, Parks A, Mohr SE, Ueda R, Kondo S, Ni JQ, Perrimon N. The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. Genetics. 2015 Nov; 201(3):843-52. PMID: 26320097; PMCID: PMC4649654 [Available on 11/01/16].
  5. Mohr SE, Hu Y, Rudd K, Buckner M, Gilly Q, Foster B, Sierzputowska K, Comjean A, Ye B, Perrimon N. Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells. G3 (Bethesda). 2015 Sep; 5(9):1919-24. PMID: 26199285; PMCID: PMC4555228.
  6. Hu Y, Comjean A, Perkins LA, Perrimon N, Mohr SE. GLAD: an Online Database of Gene List Annotation for Drosophila. J Genomics. 2015; 3:75-81. PMID: 26157507; PMCID: PMC4495321.
  7. Mohr SE, Smith JA, Shamu CE, Neumüller RA, Perrimon N. RNAi screening comes of age: improved techniques and complementary approaches. Nat Rev Mol Cell Biol. 2014 Sep; 15(9):591-600. PMID: 25145850; PMCID: PMC4204798.
  8. Yilmazel B, Hu Y, Sigoillot F, Smith JA, Shamu CE, Perrimon N, Mohr SE. Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis. BMC Bioinformatics. 2014; 15:192. PMID: 24934636; PMCID: PMC4073188.
  9. Zhou R, Mohr S, Hannon GJ, Perrimon N. Inducing RNAi in Drosophila cells by soaking with dsRNA. Cold Spring Harb Protoc. 2014 May; 2014(5). PMID: 24786505; PMCID: PMC4465107.
  10. Mohr SE, Hu Y, Kim K, Housden BE, Perrimon N. Resources for functional genomics studies in Drosophila melanogaster. Genetics. 2014 May; 197(1):1-18. PMID: 24653003; PMCID: PMC4012471.
  11. Mohr SE. RNAi screening in Drosophila cells and in vivo. Methods. 2014 Jun 15; 68(1):82-8. PMID: 24576618; PMCID: PMC4206080.
  12. Vinayagam A, Zirin J, Roesel C, Hu Y, Yilmazel B, Samsonova AA, Neumüller RA, Mohr SE, Perrimon N. Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Nat Methods. 2014 Jan; 11(1):94-9. PMID: 24240319; PMCID: PMC3877743.
  13. Ren X, Sun J, Housden BE, Hu Y, Roesel C, Lin S, Liu LP, Yang Z, Mao D, Sun L, Wu Q, Ji JY, Xi J, Mohr SE, Xu J, Perrimon N, Ni JQ. Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A. 2013 Nov 19; 110(47):19012-7. PMID: 24191015; PMCID: PMC3839733.
  14. Hu Y, Sopko R, Foos M, Kelley C, Flockhart I, Ammeux N, Wang X, Perkins L, Perrimon N, Mohr SE. FlyPrimerBank: an online database for Drosophila melanogaster gene expression analysis and knockdown evaluation of RNAi reagents. G3 (Bethesda). 2013 Sep; 3(9):1607-16. PMID: 23893746; PMCID: PMC3755921.
  15. Hu Y, Roesel C, Flockhart I, Perkins L, Perrimon N, Mohr SE. UP-TORR: online tool for accurate and Up-to-Date annotation of RNAi Reagents. Genetics. 2013 Sep; 195(1):37-45. PMID: 23792952; PMCID: PMC3761311.
  16. Zhou R, Mohr S, Hannon GJ, Perrimon N. Inducing RNAi in Drosophila cells by transfection with dsRNA. Cold Spring Harb Protoc. 2013 May; 2013(5):461-3. PMID: 23637371.
    View in: PubMed
  17. Bergwitz C, Wee MJ, Sinha S, Huang J, DeRobertis C, Mensah LB, Cohen J, Friedman A, Kulkarni M, Hu Y, Vinayagam A, Schnall-Levin M, Berger B, Perkins LA, Mohr SE, Perrimon N. Genetic determinants of phosphate response in Drosophila. PLoS One. 2013; 8(3):e56753. PMID: 23520455; PMCID: PMC3592877.
  18. Vinayagam A, Hu Y, Kulkarni M, Roesel C, Sopko R, Mohr SE, Perrimon N. Protein complex-based analysis framework for high-throughput data sets. Sci Signal. 2013 Feb 26; 6(264):rs5. PMID: 23443684; PMCID: PMC3756668.
  19. Neumüller RA, Wirtz-Peitz F, Lee S, Kwon Y, Buckner M, Hoskins RA, Venken KJ, Bellen HJ, Mohr SE, Perrimon N. Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes. Genetics. 2012 Mar; 190(3):931-40. PMID: 22174071; PMCID: PMC3296255.
  20. Flockhart IT, Booker M, Hu Y, McElvany B, Gilly Q, Mathey-Prevot B, Perrimon N, Mohr SE. database of the Drosophila RNAi screening center: 2012 update. Nucleic Acids Res. 2012 Jan; 40(Database issue):D715-9. PMID: 22067456; PMCID: PMC3245182.
  21. Mohr SE, Perrimon N. RNAi screening: new approaches, understandings, and organisms. Wiley Interdiscip Rev RNA. 2012 Mar-Apr; 3(2):145-58. PMID: 21953743; PMCID: PMC3249004.
  22. Hu Y, Flockhart I, Vinayagam A, Bergwitz C, Berger B, Perrimon N, Mohr SE. An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics. 2011; 12:357. PMID: 21880147; PMCID: PMC3179972.
  23. Booker M, Samsonova AA, Kwon Y, Flockhart I, Mohr SE, Perrimon N. False negative rates in Drosophila cell-based RNAi screens: a case study. BMC Genomics. 2011; 12:50. PMID: 21251254; PMCID: PMC3036618.
  24. Markey AL, Mohr S, Day PJ. High-throughput droplet PCR. Methods. 2010 Apr; 50(4):277-81. PMID: 20117212.
    View in: PubMed
  25. Mohr S, Bakal C, Perrimon N. Genomic screening with RNAi: results and challenges. Annu Rev Biochem. 2010; 79:37-64. PMID: 20367032; PMCID: PMC3564595.
  26. Cormier CY, Mohr SE, Zuo D, Hu Y, Rolfs A, Kramer J, Taycher E, Kelley F, Fiacco M, Turnbull G, LaBaer J. Protein Structure Initiative Material Repository: an open shared public resource of structural genomics plasmids for the biological community. Nucleic Acids Res. 2010 Jan; 38(Database issue):D743-9. PMID: 19906724; PMCID: PMC2808882.
  27. Myrick KV, Huet F, Mohr SE, Alvarez-García I, Lu JT, Smith MA, Crosby MA, Gelbart WM. Large-scale functional annotation and expanded implementations of the P{wHy} hybrid transposon in the Drosophila melanogaster genome. Genetics. 2009 Jul; 182(3):653-60. PMID: 19398769; PMCID: PMC2710148.
  28. Rolfs A, Montor WR, Yoon SS, Hu Y, Bhullar B, Kelley F, McCarron S, Jepson DA, Shen B, Taycher E, Mohr SE, Zuo D, Williamson J, Mekalanos J, Labaer J. Production and sequence validation of a complete full length ORF collection for the pathogenic bacterium Vibrio cholerae. Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11):4364-9. PMID: 18337508; PMCID: PMC2393773.
  29. Murthy T, Rolfs A, Hu Y, Shi Z, Raphael J, Moreira D, Kelley F, McCarron S, Jepson D, Taycher E, Zuo D, Mohr SE, Fernandez M, Brizuela L, LaBaer J. A full-genomic sequence-verified protein-coding gene collection for Francisella tularensis. PLoS One. 2007; 2(6):e577. PMID: 17593976; PMCID: PMC1894649.
  30. Taycher E, Rolfs A, Hu Y, Zuo D, Mohr SE, Williamson J, Labaer J. A novel approach to sequence validating protein expression clones with automated decision making. BMC Bioinformatics. 2007; 8:198. PMID: 17567908; PMCID: PMC1914086.
  31. Hu Y, Rolfs A, Bhullar B, Murthy TV, Zhu C, Berger MF, Camargo AA, Kelley F, McCarron S, Jepson D, Richardson A, Raphael J, Moreira D, Taycher E, Zuo D, Mohr S, Kane MF, Williamson J, Simpson A, Bulyk ML, Harlow E, Marsischky G, Kolodner RD, LaBaer J. Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae. Genome Res. 2007 Apr; 17(4):536-43. PMID: 17322287; PMCID: PMC1832101.
  32. Zuo D, Mohr SE, Hu Y, Taycher E, Rolfs A, Kramer J, Williamson J, LaBaer J. PlasmID: a centralized repository for plasmid clone information and distribution. Nucleic Acids Res. 2007 Jan; 35(Database issue):D680-4. PMID: 17132831; PMCID: PMC1716714.
  33. Mohr SE, Gelbart WM. Using the P[wHy] hybrid transposable element to disrupt genes in region 54D-55B in Drosophila melanogaster. Genetics. 2002 Sep; 162(1):165-76. PMID: 12242231; PMCID: PMC1462237.
  34. Mohr SE, Boswell RE. Genetic analysis of Drosophila melanogaster polytene chromosome region 44D-45F: loci required for viability and fertility. Genetics. 2002 Apr; 160(4):1503-10. PMID: 11973305; PMCID: PMC1462071.
  35. Mohr SE, Dillon ST, Boswell RE. The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis. Genes Dev. 2001 Nov 1; 15(21):2886-99. PMID: 11691839; PMCID: PMC312802.
  36. Curcio C, Baqui MM, Salvatore D, Rihn BH, Mohr S, Harney JW, Larsen PR, Bianco AC. The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem. 2001 Aug 10; 276(32):30183-7. PMID: 11425850.
    View in: PubMed
  37. Mohr S, Wanner LA, Bertrand H, Lambowitz AM. Characterization of an unusual tRNA-like sequence found inserted in a Neurospora retroplasmid. Nucleic Acids Res. 2000 Jul 1; 28(13):1514-24. PMID: 11001704.
    View in: PubMed
  38. Mohr S, Wanner LA, Bertrand H, Lambowitz AM. Characterization of an unusual tRNA-like sequence found inserted in a Neurospora retroplasmid. Nucleic Acids Res. 2000 Apr 1; 28(7):1514-24. PMID: 10710417; PMCID: PMC117792.
  39. Mohr SE, Boswell RE. Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential gene in Drosophila melanogaster. Gene. 1999 Mar 18; 229(1-2):109-16. PMID: 10095110.
    View in: PubMed
  40. Newmark PA, Mohr SE, Gong L, Boswell RE. mago nashi mediates the posterior follicle cell-to-oocyte signal to organize axis formation in Drosophila. Development. 1997 Aug; 124(16):3197-207. PMID: 9272960.
    View in: PubMed
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