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profileEdward M. Scolnick, M.D.

TitleSenior Lecturer on Genetics, Part-time
InstitutionHarvard Medical School
DepartmentGenetics
AddressHarvard Medical School
NRB, Dept. of Genetics
77 Avenue Louis Pasteur
Boston MA 02115
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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
RL1GM084437     (SCOLNICK, EDWARD MARK)Sep 30, 2007 - Jun 30, 2013
NIH/NIGMS
Driving Medical Projects (4 of 4)
Role: Principal Investigator

UL1RR024924     (SCOLNICK, EDWARD MARK)Sep 20, 2007 - Jun 30, 2012
NIH/NCRR
Genomics Based Drug Discovery
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Scolnick EM. The Path to New Therapies for Schizophrenia and Bipolar Illness. FASEB J. 2017 Apr; 31(4):1254-1259. PMID: 28360375.
    View in: PubMed
  2. Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA, Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2017 Aug; 22(8):1223. PMID: 28194006.
    View in: PubMed
  3. Marshall CR, Howrigan DP, Merico D, Thiruvahindrapuram B, Wu W, Greer DS, Antaki D, Shetty A, Holmans PA, Pinto D, Gujral M, Brandler WM, Malhotra D, Wang Z, Fajarado KVF, Maile MS, Ripke S, Agartz I, Albus M, Alexander M, Amin F, Atkins J, Bacanu SA, Belliveau RA, Bergen SE, Bertalan M, Bevilacqua E, Bigdeli TB, Black DW, Bruggeman R, Buccola NG, Buckner RL, Bulik-Sullivan B, Byerley W, Cahn W, Cai G, Cairns MJ, Campion D, Cantor RM, Carr VJ, Carrera N, Catts SV, Chambert KD, Cheng W, Cloninger CR, Cohen D, Cormican P, Craddock N, Crespo-Facorro B, Crowley JJ, Curtis D, Davidson M, Davis KL, Degenhardt F, Del Favero J, DeLisi LE, Dikeos D, Dinan T, Djurovic S, Donohoe G, Drapeau E, Duan J, Dudbridge F, Eichhammer P, Eriksson J, Escott-Price V, Essioux L, Fanous AH, Farh KH, Farrell MS, Frank J, Franke L, Freedman R, Freimer NB, Friedman JI, Forstner AJ, Fromer M, Genovese G, Georgieva L, Gershon ES, Giegling I, Giusti-Rodríguez P, Godard S, Goldstein JI, Gratten J, de Haan L, Hamshere ML, Hansen M, Hansen T, Haroutunian V, Hartmann AM, Henskens FA, Herms S, Hirschhorn JN, Hoffmann P, Hofman A, Huang H, Ikeda M, Joa I, Kähler AK, Kahn RS, Kalaydjieva L, Karjalainen J, Kavanagh D, Keller MC, Kelly BJ, Kennedy JL, Kim Y, Knowles JA, Konte B, Laurent C, Lee P, Lee SH, Legge SE, Lerer B, Levy DL, Liang KY, Lieberman J, Lönnqvist J, Loughland CM, Magnusson PKE, Maher BS, Maier W, Mallet J, Mattheisen M, Mattingsdal M, McCarley RW, McDonald C, McIntosh AM, Meier S, Meijer CJ, Melle I, Mesholam-Gately RI, Metspalu A, Michie PT, Milani L, Milanova V, Mokrab Y, Morris DW, Müller-Myhsok B, Murphy KC, Murray RM, Myin-Germeys I, Nenadic I, Nertney DA, Nestadt G, Nicodemus KK, Nisenbaum L, Nordin A, O'Callaghan E, O'Dushlaine C, Oh SY, Olincy A, Olsen L, O'Neill FA, Van Os J, Pantelis C, Papadimitriou GN, Parkhomenko E, Pato MT, Paunio T, Perkins DO, Pers TH, Pietiläinen O, Pimm J, Pocklington AJ, Powell J, Price A, Pulver AE, Purcell SM, Quested D, Rasmussen HB, Reichenberg A, Reimers MA, Richards AL, Roffman JL, Roussos P, Ruderfer DM, Salomaa V, Sanders AR, Savitz A, Schall U, Schulze TG, Schwab SG, Scolnick EM, Scott RJ, Seidman LJ, Shi J, Silverman JM, Smoller JW, Söderman E, Spencer CCA, Stahl EA, Strengman E, Strohmaier J, Stroup TS, Suvisaari J, Svrakic DM, Szatkiewicz JP, Thirumalai S, Tooney PA, Veijola J, Visscher PM, Waddington J, Walsh D, Webb BT, Weiser M, Wildenauer DB, Williams NM, Williams S, Witt SH, Wolen AR, Wormley BK, Wray NR, Wu JQ, Zai CC, Adolfsson R, Andreassen OA, Blackwood DHR, Bramon E, Buxbaum JD, Cichon S, Collier DA, Corvin A, Daly MJ, Darvasi A, Domenici E, Esko T, Gejman PV, Gill M, Gurling H, Hultman CM, Iwata N, Jablensky AV, Jönsson EG, Kendler KS, Kirov G, Knight J, Levinson DF, Li QS, McCarroll SA, McQuillin A, Moran JL, Mowry BJ, Nöthen MM, Ophoff RA, Owen MJ, Palotie A, Pato CN, Petryshen TL, Posthuma D, Rietschel M, Riley BP, Rujescu D, Sklar P, St Clair D, Walters JTR, Werge T, Sullivan PF, O'Donovan MC, Scherer SW, Neale BM, Sebat J. Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nat Genet. 2017 Jan; 49(1):27-35. PMID: 27869829.
    View in: PubMed
  4. Kim MJ, Biag J, Fass DM, Lewis MC, Zhang Q, Fleishman M, Gangwar SP, Machius M, Fromer M, Purcell SM, McCarroll SA, Rudenko G, Premont RT, Scolnick EM, Haggarty SJ. Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity. Mol Psychiatry. 2017 Mar; 22(3):417-429. PMID: 27457813.
    View in: PubMed
  5. Song J, Bergen SE, Di Florio A, Karlsson R, Charney A, Ruderfer DM, Stahl EA, Chambert KD, Moran JL, Gordon-Smith K, Forty L, Green EK, Jones I, Jones L, Scolnick EM, Sklar P, Smoller JW, Lichtenstein P, Hultman C, Craddock N, Landén M, Smoller JW, Perlis RH, Lee PH, Castro VM, Hoffnagle AG, Sklar P, Stahl EA, Purcell SM, Ruderfer DM, Charney AW, Roussos P, Michele Pato CP, Medeiros H, Sobel J, Craddock N, Jones I, Forty L, Florio AD, Green E, Jones L, Gordon-Smith K, Landen M, Hultman C, Jureus A, Bergen S, McCarroll S, Moran J, Smoller JW, Chambert K, Belliveau RA. Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder. Mol Psychiatry. 2016 Sep; 21(9):1290-7. PMID: 26503763; PMCID: PMC4995544.
  6. Rees E, Kirov G, Walters JT, Richards AL, Howrigan D, Kavanagh DH, Pocklington AJ, Fromer M, Ruderfer DM, Georgieva L, Carrera N, Gormley P, Palta P, Williams H, Dwyer S, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Tsuang MT, Glatt SJ, Chen WJ, Hwu HG, Neale BM, Palotie A, Sklar P, Purcell SM, McCarroll SA, Holmans P, Owen MJ, O'Donovan MC. Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia. Transl Psychiatry. 2015 Jul 21; 5:e607. PMID: 26196440.
    View in: PubMed
  7. Wagner FF, Zhang YL, Fass DM, Joseph N, Gale JP, Weïwer M, McCarren P, Fisher SL, Kaya T, Zhao WN, Reis SA, Hennig KM, Thomas M, Lemercier BC, Lewis MC, Guan JS, Moyer MP, Scolnick E, Haggarty SJ, Tsai LH, Holson EB. Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers. Chem Sci. 2015 Jan 01; 6(1):804-815. PMID: 25642316.
    View in: PubMed
  8. Szatkiewicz JP, O'Dushlaine C, Chen G, Chambert K, Moran JL, Neale BM, Fromer M, Ruderfer D, Akterin S, Bergen SE, Kähler A, Magnusson PK, Kim Y, Crowley JJ, Rees E, Kirov G, O'Donovan MC, Owen MJ, Walters J, Scolnick E, Sklar P, Purcell S, Hultman CM, McCarroll SA, Sullivan PF. Copy number variation in schizophrenia in Sweden. Mol Psychiatry. 2014 Jul; 19(7):762-73. PMID: 24776740; PMCID: PMC4271733.
  9. Morris DW, Pearson RD, Cormican P, Kenny EM, O'Dushlaine CT, Perreault LP, Giannoulatou E, Tropea D, Maher BS, Wormley B, Kelleher E, Fahey C, Molinos I, Bellini S, Pirinen M, Strange A, Freeman C, Thiselton DL, Elves RL, Regan R, Ennis S, Dinan TG, McDonald C, Murphy KC, O'Callaghan E, Waddington JL, Walsh D, O'Donovan M, Grozeva D, Craddock N, Stone J, Scolnick E, Purcell S, Sklar P, Coe B, Eichler EE, Ophoff R, Buizer J, Szatkiewicz J, Hultman C, Sullivan P, Gurling H, Mcquillin A, St Clair D, Rees E, Kirov G, Walters J, Blackwood D, Johnstone M, Donohoe G, O'Neill FA, Kendler KS, Gill M, Riley BP, Spencer CC, Corvin A. An inherited duplication at the gene p21 Protein-Activated Kinase 7 (PAK7) is a risk factor for psychosis. Hum Mol Genet. 2014 Jun 15; 23(12):3316-26. PMID: 24474471; PMCID: PMC4030770.
  10. Purcell SM, Moran JL, Fromer M, Ruderfer D, Solovieff N, Roussos P, O'Dushlaine C, Chambert K, Bergen SE, Kähler A, Duncan L, Stahl E, Genovese G, Fernández E, Collins MO, Komiyama NH, Choudhary JS, Magnusson PK, Banks E, Shakir K, Garimella K, Fennell T, DePristo M, Grant SG, Haggarty SJ, Gabriel S, Scolnick EM, Lander ES, Hultman CM, Sullivan PF, McCarroll SA, Sklar P. A polygenic burden of rare disruptive mutations in schizophrenia. Nature. 2014 Feb 13; 506(7487):185-90. PMID: 24463508; PMCID: PMC4136494.
  11. Fromer M, Pocklington AJ, Kavanagh DH, Williams HJ, Dwyer S, Gormley P, Georgieva L, Rees E, Palta P, Ruderfer DM, Carrera N, Humphreys I, Johnson JS, Roussos P, Barker DD, Banks E, Milanova V, Grant SG, Hannon E, Rose SA, Chambert K, Mahajan M, Scolnick EM, Moran JL, Kirov G, Palotie A, McCarroll SA, Holmans P, Sklar P, Owen MJ, Purcell SM, O'Donovan MC. De novo mutations in schizophrenia implicate synaptic networks. Nature. 2014 Feb 13; 506(7487):179-84. PMID: 24463507; PMCID: PMC4237002.
  12. Ripke S, O'Dushlaine C, Chambert K, Moran JL, Kähler AK, Akterin S, Bergen SE, Collins AL, Crowley JJ, Fromer M, Kim Y, Lee SH, Magnusson PK, Sanchez N, Stahl EA, Williams S, Wray NR, Xia K, Bettella F, Borglum AD, Bulik-Sullivan BK, Cormican P, Craddock N, de Leeuw C, Durmishi N, Gill M, Golimbet V, Hamshere ML, Holmans P, Hougaard DM, Kendler KS, Lin K, Morris DW, Mors O, Mortensen PB, Neale BM, O'Neill FA, Owen MJ, Milovancevic MP, Posthuma D, Powell J, Richards AL, Riley BP, Ruderfer D, Rujescu D, Sigurdsson E, Silagadze T, Smit AB, Stefansson H, Steinberg S, Suvisaari J, Tosato S, Verhage M, Walters JT, Levinson DF, Gejman PV, Kendler KS, Laurent C, Mowry BJ, O'Donovan MC, Owen MJ, Pulver AE, Riley BP, Schwab SG, Wildenauer DB, Dudbridge F, Holmans P, Shi J, Albus M, Alexander M, Campion D, Cohen D, Dikeos D, Duan J, Eichhammer P, Godard S, Hansen M, Lerer FB, Liang KY, Maier W, Mallet J, Nertney DA, Nestadt G, Norton N, O'Neill FA, Papadimitriou GN, Ribble R, Sanders AR, Silverman JM, Walsh D, Williams NM, Wormley B, Arranz MJ, Bakker S, Bender S, Bramon E, Collier D, Crespo-Facorro B, Hall J, Iyegbe C, Jablensky A, Kahn RS, Kalaydjieva L, Lawrie S, Lewis CM, Lin K, Linszen DH, Mata I, McIntosh A, Murray RM, Ophoff RA, Powell J, Rujescu D, Van Os J, Walshe M, Weisbrod M, Wiersma D, Donnelly P, Barroso I, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin AP, Deloukas P, Duncanson A, Jankowski J, Markus HS, Mathew CG, Palmer CN, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Spencer CC, Band G, Bellenguez C, Freeman C, Hellenthal G, Giannoulatou E, Pirinen M, Pearson RD, Strange A, Su Z, Vukcevic D, Donnelly P, Langford C, Hunt SE, Edkins S, Gwilliam R, Blackburn H, Bumpstead SJ, Dronov S, Gillman M, Gray E, Hammond N, Jayakumar A, McCann OT, Liddle J, Potter SC, Ravindrarajah R, Ricketts M, Tashakkori-Ghanbaria A, Waller MJ, Weston P, Widaa S, Whittaker P, Barroso I, Deloukas P, Mathew CG, Blackwell JM, Brown MA, Corvin AP, McCarthy MI, Spencer CC, Bramon E, Corvin AP, O'Donovan MC, Stefansson K, Scolnick E, Purcell S, McCarroll SA, Sklar P, Hultman CM, Sullivan PF. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet. 2013 Oct; 45(10):1150-9. PMID: 23974872; PMCID: PMC3827979.
  13. Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, Andreassen OA, Anjorin A, Anney R, Anttila V, Arking DE, Asherson P, Azevedo MH, Backlund L, Badner JA, Bailey AJ, Banaschewski T, Barchas JD, Barnes MR, Barrett TB, Bass N, Battaglia A, Bauer M, Bayés M, Bellivier F, Bergen SE, Berrettini W, Betancur C, Bettecken T, Biederman J, Binder EB, Black DW, Blackwood DH, Bloss CS, Boehnke M, Boomsma DI, Breen G, Breuer R, Bruggeman R, Cormican P, Buccola NG, Buitelaar JK, Bunney WE, Buxbaum JD, Byerley WF, Byrne EM, Caesar S, Cahn W, Cantor RM, Casas M, Chakravarti A, Chambert K, Choudhury K, Cichon S, Cloninger CR, Collier DA, Cook EH, Coon H, Cormand B, Corvin A, Coryell WH, Craig DW, Craig IW, Crosbie J, Cuccaro ML, Curtis D, Czamara D, Datta S, Dawson G, Day R, De Geus EJ, Degenhardt F, Djurovic S, Donohoe GJ, Doyle AE, Duan J, Dudbridge F, Duketis E, Ebstein RP, Edenberg HJ, Elia J, Ennis S, Etain B, Fanous A, Farmer AE, Ferrier IN, Flickinger M, Fombonne E, Foroud T, Frank J, Franke B, Fraser C, Freedman R, Freimer NB, Freitag CM, Friedl M, Frisén L, Gallagher L, Gejman PV, Georgieva L, Gershon ES, Geschwind DH, Giegling I, Gill M, Gordon SD, Gordon-Smith K, Green EK, Greenwood TA, Grice DE, Gross M, Grozeva D, Guan W, Gurling H, De Haan L, Haines JL, Hakonarson H, Hallmayer J, Hamilton SP, Hamshere ML, Hansen TF, Hartmann AM, Hautzinger M, Heath AC, Henders AK, Herms S, Hickie IB, Hipolito M, Hoefels S, Holmans PA, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hultman CM, Hus V, Ingason A, Ising M, Jamain S, Jones EG, Jones I, Jones L, Tzeng JY, Kähler AK, Kahn RS, Kandaswamy R, Keller MC, Kennedy JL, Kenny E, Kent L, Kim Y, Kirov GK, Klauck SM, Klei L, Knowles JA, Kohli MA, Koller DL, Konte B, Korszun A, Krabbendam L, Krasucki R, Kuntsi J, Kwan P, Landén M, Långström N, Lathrop M, Lawrence J, Lawson WB, Leboyer M, Ledbetter DH, Lee PH, Lencz T, Lesch KP, Levinson DF, Lewis CM, Li J, Lichtenstein P, Lieberman JA, Lin DY, Linszen DH, Liu C, Lohoff FW, Loo SK, Lord C, Lowe JK, Lucae S, MacIntyre DJ, Madden PA, Maestrini E, Magnusson PK, Mahon PB, Maier W, Malhotra AK, Mane SM, Martin CL, Martin NG, Mattheisen M, Matthews K, Mattingsdal M, McCarroll SA, McGhee KA, McGough JJ, McGrath PJ, McGuffin P, McInnis MG, McIntosh A, McKinney R, McLean AW, McMahon FJ, McMahon WM, McQuillin A, Medeiros H, Medland SE, Meier S, Melle I, Meng F, Meyer J, Middeldorp CM, Middleton L, Milanova V, Miranda A, Monaco AP, Montgomery GW, Moran JL, Moreno-De-Luca D, Morken G, Morris DW, Morrow EM, Moskvina V, Muglia P, Mühleisen TW, Muir WJ, Müller-Myhsok B, Murtha M, Myers RM, Myin-Germeys I, Neale MC, Nelson SF, Nievergelt CM, Nikolov I, Nimgaonkar V, Nolen WA, Nöthen MM, Nurnberger JI, Nwulia EA, Nyholt DR, O'Dushlaine C, Oades RD, Olincy A, Oliveira G, Olsen L, Ophoff RA, Osby U, Owen MJ, Palotie A, Parr JR, Paterson AD, Pato CN, Pato MT, Penninx BW, Pergadia ML, Pericak-Vance MA, Pickard BS, Pimm J, Piven J, Posthuma D, Potash JB, Poustka F, Propping P, Puri V, Quested DJ, Quinn EM, Ramos-Quiroga JA, Rasmussen HB, Raychaudhuri S, Rehnström K, Reif A, Ribasés M, Rice JP, Rietschel M, Roeder K, Roeyers H, Rossin L, Rothenberger A, Rouleau G, Ruderfer D, Rujescu D, Sanders AR, Sanders SJ, Santangelo SL, Sergeant JA, Schachar R, Schalling M, Schatzberg AF, Scheftner WA, Schellenberg GD, Scherer SW, Schork NJ, Schulze TG, Schumacher J, Schwarz M, Scolnick E, Scott LJ, Shi J, Shilling PD, Shyn SI, Silverman JM, Slager SL, Smalley SL, Smit JH, Smith EN, Sonuga-Barke EJ, St Clair D, State M, Steffens M, Steinhausen HC, Strauss JS, Strohmaier J, Stroup TS, Sutcliffe JS, Szatmari P, Szelinger S, Thirumalai S, Thompson RC, Todorov AA, Tozzi F, Treutlein J, Uhr M, van den Oord EJ, Van Grootheest G, Van Os J, Vicente AM, Vieland VJ, Vincent JB, Visscher PM, Walsh CA, Wassink TH, Watson SJ, Weissman MM, Werge T, Wienker TF, Wijsman EM, Willemsen G, Williams N, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet. 2013 Sep; 45(9):984-94. PMID: 23933821; PMCID: PMC3800159.
  14. Plenge RM, Scolnick EM, Altshuler D. Validating therapeutic targets through human genetics. Nat Rev Drug Discov. 2013 Aug; 12(8):581-94. PMID: 23868113.
    View in: PubMed
  15. Bergen SE, O'Dushlaine CT, Ripke S, Lee PH, Ruderfer DM, Akterin S, Moran JL, Chambert KD, Handsaker RE, Backlund L, Ösby U, McCarroll S, Landen M, Scolnick EM, Magnusson PK, Lichtenstein P, Hultman CM, Purcell SM, Sklar P, Sullivan PF. Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder. Mol Psychiatry. 2012 Sep; 17(9):880-6. PMID: 22688191; PMCID: PMC3724337.
  16. Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Sawa A, Saw A, Caron MG, George SR, Allen JA, Solis M. Advancing drug discovery for schizophrenia. Ann N Y Acad Sci. 2011 Oct; 1236:30-43. PMID: 22032400; PMCID: PMC3787879.
  17. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011 Sep 18; 43(10):977-83. PMID: 21926972; PMCID: PMC3637176.
  18. Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 2011 Sep 18; 43(10):969-76. PMID: 21926974; PMCID: PMC3303194.
  19. Kuai L, Ong SE, Madison JM, Wang X, Duvall JR, Lewis TA, Luce CJ, Conner SD, Pearlman DA, Wood JL, Schreiber SL, Carr SA, Scolnick EM, Haggarty SJ. AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics. Chem Biol. 2011 Jul 29; 18(7):891-906. PMID: 21802010; PMCID: PMC3368601.
  20. Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ. AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology. 2011 Jun; 36(7):1397-411. PMID: 21389981; PMCID: PMC3096809.
  21. Chen X, Lee G, Maher BS, Fanous AH, Chen J, Zhao Z, Guo A, van den Oord E, Sullivan PF, Shi J, Levinson DF, Gejman PV, Sanders A, Duan J, Owen MJ, Craddock NJ, O'Donovan MC, Blackman J, Lewis D, Kirov GK, Qin W, Schwab S, Wildenauer D, Chowdari K, Nimgaonkar V, Straub RE, Weinberger DR, O'Neill FA, Walsh D, Bronstein M, Darvasi A, Lencz T, Malhotra AK, Rujescu D, Giegling I, Werge T, Hansen T, Ingason A, Nöethen MM, Rietschel M, Cichon S, Djurovic S, Andreassen OA, Cantor RM, Ophoff R, Corvin A, Morris DW, Gill M, Pato CN, Pato MT, Macedo A, Gurling HM, McQuillin A, Pimm J, Hultman C, Lichtenstein P, Sklar P, Purcell SM, Scolnick E, St Clair D, Blackwood DH, Kendler KS. GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia. Mol Psychiatry. 2011 Nov; 16(11):1117-29. PMID: 20838396; PMCID: PMC3443634.
  22. Liu Y, Blackwood DH, Caesar S, de Geus EJ, Farmer A, Ferreira MA, Ferrier IN, Fraser C, Gordon-Smith K, Green EK, Grozeva D, Gurling HM, Hamshere ML, Heutink P, Holmans PA, Hoogendijk WJ, Hottenga JJ, Jones L, Jones IR, Kirov G, Lin D, McGuffin P, Moskvina V, Nolen WA, Perlis RH, Posthuma D, Scolnick EM, Smit AB, Smit JH, Smoller JW, St Clair D, van Dyck R, Verhage M, Willemsen G, Young AH, Zandbelt T, Boomsma DI, Craddock N, O'Donovan MC, Owen MJ, Penninx BW, Purcell S, Sklar P, Sullivan PF. Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. Mol Psychiatry. 2011 Jan; 16(1):2-4. PMID: 20351715; PMCID: PMC3883627.
  23. Akil H, Brenner S, Kandel E, Kendler KS, King MC, Scolnick E, Watson JD, Zoghbi HY. Medicine. The future of psychiatric research: genomes and neural circuits. Science. 2010 Mar 26; 327(5973):1580-1. PMID: 20339051; PMCID: PMC3091000.
  24. Nyegaard M, Severinsen JE, Als TD, Hedemand A, Straarup S, Nordentoft M, McQuillin A, Bass N, Lawrence J, Thirumalai S, Pereira ACP, Kandaswamy R, Lydall GJ, Sklar P, Scolnick E, Purcell S, Curtis D, Gurling HMD, Mortensen PB, Mors O, Børglum AD. Support of association between BRD1 and both schizophrenia and bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 05; 153B(2):582-591. PMID: 19693800.
    View in: PubMed
  25. Kuai L, Wang X, Madison JM, Schreiber SL, Scolnick EM, Haggarty SJ. Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling. ACS Chem Neurosci. 2010 Jan 28; 1(4):325-342. PMID: 20495671.
    View in: PubMed
  26. Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC, Purcell SM, Sklar P, Scolnick EM, Xavier RJ, Altshuler D, Daly MJ. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet. 2009 Jun; 5(6):e1000534. PMID: 19557189; PMCID: PMC2694358.
  27. Perlis RH, Smoller JW, Ferreira MA, McQuillin A, Bass N, Lawrence J, Sachs GS, Nimgaonkar V, Scolnick EM, Gurling H, Sklar P, Purcell S. A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder. Am J Psychiatry. 2009 Jun; 166(6):718-25. PMID: 19448189; PMCID: PMC3908470.
  28. Ferreira MA, O'Donovan MC, Meng YA, Jones IR, Ruderfer DM, Jones L, Fan J, Kirov G, Perlis RH, Green EK, Smoller JW, Grozeva D, Stone J, Nikolov I, Chambert K, Hamshere ML, Nimgaonkar VL, Moskvina V, Thase ME, Caesar S, Sachs GS, Franklin J, Gordon-Smith K, Ardlie KG, Gabriel SB, Fraser C, Blumenstiel B, Defelice M, Breen G, Gill M, Morris DW, Elkin A, Muir WJ, McGhee KA, Williamson R, MacIntyre DJ, MacLean AW, St CD, Robinson M, Van Beck M, Pereira AC, Kandaswamy R, McQuillin A, Collier DA, Bass NJ, Young AH, Lawrence J, Ferrier IN, Anjorin A, Farmer A, Curtis D, Scolnick EM, McGuffin P, Daly MJ, Corvin AP, Holmans PA, Blackwood DH, Gurling HM, Owen MJ, Purcell SM, Sklar P, Craddock N. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. Nat Genet. 2008 Sep; 40(9):1056-8. PMID: 18711365; PMCID: PMC2703780.
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  36. Xiong Y, Wiltsie J, Woods A, Guo J, Pivnichny JV, Tang W, Bansal A, Cummings RT, Cunningham BR, Friedlander AM, Douglas CM, Salowe SP, Zaller DM, Scolnick EM, Schmatz DM, Bartizal K, Hermes JD, MacCoss M, Chapman KT. The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. Bioorg Med Chem Lett. 2006 Feb 15; 16(4):964-8. PMID: 16338135.
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  41. Sur C, Mallorga PJ, Wittmann M, Jacobson MA, Pascarella D, Williams JB, Brandish PE, Pettibone DJ, Scolnick EM, Conn PJ. N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl-D-aspartate receptor activity. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13674-9. PMID: 14595031; PMCID: PMC263872.
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  45. Scolnick EM. Discovery and development of antidepressants: a perspective from a pharmaceutical discovery company. Biol Psychiatry. 2002 Aug 01; 52(3):154-6. PMID: 12182921.
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  47. Scolnick EM, Slater EE, Williams GW. "Natural history" clinical trials: an enduring contribution to modern medical practice. Adv Protein Chem. 2001; 56:1-12. PMID: 11329850.
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  50. Gibbs JB, Pompliano DL, Mosser SD, Rands E, Lingham RB, Singh SB, Scolnick EM, Kohl NE, Oliff A. Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo. J Biol Chem. 1993 Apr 15; 268(11):7617-20. PMID: 8463291.
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  51. Marshall MS, Davis LJ, Keys RD, Mosser SD, Hill WS, Scolnick EM, Gibbs JB. Identification of amino acid residues required for Ras p21 target activation. Mol Cell Biol. 1991 Aug; 11(8):3997-4004. PMID: 1906576; PMCID: PMC361200.
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  55. Gibbs JB, Schaber MD, Schofield TL, Scolnick EM, Sigal IS. Xenopus oocyte germinal-vesicle breakdown induced by [Val12]Ras is inhibited by a cytosol-localized Ras mutant. Proc Natl Acad Sci U S A. 1989 Sep; 86(17):6630-4. PMID: 2672000; PMCID: PMC297898.
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  57. Schaber MD, Garsky VM, Boylan D, Hill WS, Scolnick EM, Marshall MS, Sigal IS, Gibbs JB. Ras interaction with the GTPase-activating protein (GAP). Proteins. 1989; 6(3):306-15. PMID: 2516318.
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  59. Kohl NE, Emini EA, Schleif WA, Davis LJ, Heimbach JC, Dixon RA, Scolnick EM, Sigal IS. Active human immunodeficiency virus protease is required for viral infectivity. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4686-90. PMID: 3290901; PMCID: PMC280500.
  60. Gibbs JB, Schaber MD, Allard WJ, Sigal IS, Scolnick EM. Purification of ras GTPase activating protein from bovine brain. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5026-30. PMID: 3293047; PMCID: PMC281680.
  61. Gibbs JB, Marsico-Ahern JD, Scolnick EM, Sigal IS. Inhibition of yeast adenylate cyclase by antibodies to ras p21. Biochem J. 1988 May 15; 252(1):289-92. PMID: 2458712; PMCID: PMC1149136.
  62. Sigal IS, Marshall MS, Schaber MD, Vogel US, Scolnick EM, Gibbs JB. Structure/function studies of the ras protein. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:863-9. PMID: 3151189.
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  64. Marshall MS, Gibbs JB, Scolnick EM, Sigal IS. An adenylate cyclase from Saccharomyces cerevisiae that is stimulated by RAS proteins with effector mutations. Mol Cell Biol. 1988 Jan; 8(1):52-61. PMID: 3275878; PMCID: PMC363078.
  65. Sigal IS, Smith GM, Jurnak F, Marsico-Ahern JD, D'Alonzo JS, Scolnick EM, Gibbs JB. Molecular approaches towards an anti-ras drug. Anticancer Drug Des. 1987 Oct; 2(2):107-15. PMID: 3130069.
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  66. Gibbs JB, Schaber MD, Marshall MS, Scolnick EM, Sigal IS. Identification of guanine nucleotides bound to ras-encoded proteins in growing yeast cells. J Biol Chem. 1987 Aug 05; 262(22):10426-9. PMID: 3038880.
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  67. Marshall MS, Gibbs JB, Scolnick EM, Sigal IS. Regulatory function of the Saccharomyces cerevisiae RAS C-terminus. Mol Cell Biol. 1987 Jul; 7(7):2309-15. PMID: 3302671; PMCID: PMC365361.
  68. Stein RB, Tai JY, Scolnick EM. Molecular cloning of the temperature-sensitive 371 Kirsten murine sarcoma virus and expression in Escherichia coli of the mutant and wild-type viral Kirsten ras p21 proteins. J Virol. 1986 Nov; 60(2):782-6. PMID: 3022010; PMCID: PMC288958.
  69. Provost PJ, Bishop RP, Gerety RJ, Hilleman MR, McAleer WJ, Scolnick EM, Stevens CE. New findings in live, attenuated hepatitis A vaccine development. J Med Virol. 1986 Oct; 20(2):165-75. PMID: 3021899.
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  70. Emini EA, Ellis RW, Miller WJ, McAleer WJ, Scolnick EM, Gerety RJ. Production and immunological analysis of recombinant hepatitis B vaccine. J Infect. 1986 Jul; 13 Suppl A:3-9. PMID: 2427590.
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  71. Zajac BA, West DJ, McAleer WJ, Scolnick EM. Overview of clinical studies with hepatitis B vaccine made by recombinant DNA. J Infect. 1986 Jul; 13 Suppl A:39-45. PMID: 2943814.
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  72. Sigal IS, Gibbs JB, D'Alonzo JS, Scolnick EM. Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21. Proc Natl Acad Sci U S A. 1986 Jul; 83(13):4725-9. PMID: 2425352; PMCID: PMC323814.
  73. Ruta M, Wolford R, Dhar R, Defeo-Jones D, Ellis RW, Scolnick EM. Nucleotide sequence of the two rat cellular rasH genes. Mol Cell Biol. 1986 May; 6(5):1706-10. PMID: 3023901; PMCID: PMC367698.
  74. Sigal IS, Gibbs JB, D'Alonzo JS, Temeles GL, Wolanski BS, Socher SH, Scolnick EM. Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects. Proc Natl Acad Sci U S A. 1986 Feb; 83(4):952-6. PMID: 3513168; PMCID: PMC322988.
  75. Weibel RE, Kuter BJ, Neff BJ, Rothenberger CA, Fitzgerald AJ, Connor KA, Morton D, McLean AA, Scolnick EM. Live Oka/Merck varicella vaccine in healthy children. Further clinical and laboratory assessment. JAMA. 1985 Nov 01; 254(17):2435-9. PMID: 2995697.
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  76. Wampler DE, Lehman ED, Boger J, McAleer WJ, Scolnick EM. Multiple chemical forms of hepatitis B surface antigen produced in yeast. Proc Natl Acad Sci U S A. 1985 Oct; 82(20):6830-4. PMID: 2931722; PMCID: PMC390781.
  77. Tolman RL, Field AK, Karkas JD, Wagner AF, Germershausen J, Crumpacker C, Scolnick EM. 2'-Nor-cGMP: a seco-cyclic nucleotide with powerful anti-DNA-viral activity. Biochem Biophys Res Commun. 1985 May 16; 128(3):1329-35. PMID: 2988534.
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  78. Weeks MO, Hager GL, Lowe R, Scolnick EM. Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product. J Virol. 1985 May; 54(2):586-97. PMID: 2985821; PMCID: PMC254832.
  79. DeFeo-Jones D, Tatchell K, Robinson LC, Sigal IS, Vass WC, Lowy DR, Scolnick EM. Mammalian and yeast ras gene products: biological function in their heterologous systems. Science. 1985 Apr 12; 228(4696):179-84. PMID: 3883495.
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  80. Poe M, Scolnick EM, Stein RB. Viral Harvey ras p21 expressed in Escherichia coli purifies as a binary one-to-one complex with GDP. J Biol Chem. 1985 Apr 10; 260(7):3906-9. PMID: 2984188.
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  81. Hyland JK, Rogers CM, Scolnick EM, Stein RB, Ellis R, Baserga R. Microinjected ras family oncogenes stimulate DNA synthesis in quiescent mammalian cells. Virology. 1985 Mar; 141(2):333-6. PMID: 3002023.
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  82. Temeles GL, Gibbs JB, D'Alonzo JS, Sigal IS, Scolnick EM. Yeast and mammalian ras proteins have conserved biochemical properties. Nature. 1985 Feb 21-27; 313(6004):700-3. PMID: 3919305.
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  83. Hughes JV, Stanton LW, Tomassini JE, Long WJ, Scolnick EM. Neutralizing monoclonal antibodies to hepatitis A virus: partial localization of a neutralizing antigenic site. J Virol. 1984 Nov; 52(2):465-73. PMID: 6208377; PMCID: PMC254547.
  84. Temeles GL, DeFeo-Jones D, Tatchell K, Ellinger MS, Scolnick EM. Expression and characterization of ras mRNAs from Saccharomyces cerevisiae. Mol Cell Biol. 1984 Nov; 4(11):2298-305. PMID: 6392849; PMCID: PMC369058.
  85. Gibbs JB, Sigal IS, Poe M, Scolnick EM. Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules. Proc Natl Acad Sci U S A. 1984 Sep; 81(18):5704-8. PMID: 6148751; PMCID: PMC391779.
  86. Gonda MA, Kaminchick J, Oliff A, Menke J, Nagashima K, Scolnick EM. Heteroduplex analysis of molecular clones of the pathogenic Friend virus complex: Friend murine leukemia virus, Friend mink cell focus-forming virus, and the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus. J Virol. 1984 Aug; 51(2):306-14. PMID: 6086947; PMCID: PMC254439.
  87. Scolnick EM, McLean AA, West DJ, McAleer WJ, Miller WJ, Buynak EB. Clinical evaluation in healthy adults of a hepatitis B vaccine made by recombinant DNA. JAMA. 1984 Jun 01; 251(21):2812-5. PMID: 6232402.
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  89. Sakaguchi AY, Zabel BU, Grzeschik KH, Law ML, Ellis RW, Scolnick EM, Naylor SL. Regional localization of two human cellular Kirsten ras genes on chromosomes 6 and 12. Mol Cell Biol. 1984 May; 4(5):989-93. PMID: 6328282; PMCID: PMC368856.
  90. Stein RB, Robinson PS, Scolnick EM. Photoaffinity labeling with GTP of viral p21 ras protein expressed in Escherichia coli. J Virol. 1984 May; 50(2):343-51. PMID: 6323735; PMCID: PMC255626.
  91. Gibbs JB, Ellis RW, Scolnick EM. Autophosphorylation of v-Ha-ras p21 is modulated by amino acid residue 12. Proc Natl Acad Sci U S A. 1984 May; 81(9):2674-8. PMID: 6609366; PMCID: PMC345132.
  92. Dhar R, Nieto A, Koller R, DeFeo-Jones D, Scolnick EM. Nucleotide sequence of two rasH related-genes isolated from the yeast Saccharomyces cerevisiae. Nucleic Acids Res. 1984 Apr 25; 12(8):3611-8. PMID: 6328429; PMCID: PMC318772.
  93. Provost PJ, Giesa PA, Buynak EB, McLean AA, Scolnick EM. Fetal rhesus kidney cells used for hepatitis A viral vaccine development are free from polyomavirus. Lancet. 1984 Feb 18; 1(8373):395. PMID: 6141453.
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  94. Willumsen BM, Ellis RW, Scolnick EM, Lowy DR. Further genetic localization of the transforming sequences of the p21 v-ras gene of Harvey murine sarcoma virus. J Virol. 1984 Feb; 49(2):601-3. PMID: 6319763; PMCID: PMC255506.
  95. Sakaguchi AY, Lalley PA, Zabel BU, Ellis RW, Scolnick EM, Naylor SL. Chromosome assignments of four mouse cellular homologs of sarcoma and leukemia virus oncogenes. Proc Natl Acad Sci U S A. 1984 Jan; 81(2):525-9. PMID: 6320193; PMCID: PMC344711.
  96. Papageorge AG, Defeo-Jones D, Robinson P, Temeles G, Scolnick EM. Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals. Mol Cell Biol. 1984 Jan; 4(1):23-9. PMID: 6422257; PMCID: PMC368653.
  97. DeFeo-Jones D, Scolnick EM, Koller R, Dhar R. ras-Related gene sequences identified and isolated from Saccharomyces cerevisiae. Nature. 1983 Dec 15-21; 306(5944):707-9. PMID: 6318116.
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  98. Yuspa SH, Vass W, Scolnick E. Altered growth and differentiation of cultured mouse epidermal cells infected with oncogenic retrovirus: contrasting effects of viruses and chemicals. Cancer Res. 1983 Dec; 43(12 Pt 1):6021-30. PMID: 6315224.
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  99. Cooper JA, Scolnick EM, Ozanne B, Hunter T. Epidermal growth factor receptor metabolism and protein kinase activity in human A431 cells infected with Snyder-Theilen feline sarcoma virus or harvey or Kirsten murine sarcoma virus. J Virol. 1983 Dec; 48(3):752-64. PMID: 6313970; PMCID: PMC255407.
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  101. Noda M, Selinger Z, Scolnick EM, Bassin RH. Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes. Proc Natl Acad Sci U S A. 1983 Sep; 80(18):5602-6. PMID: 6604274; PMCID: PMC384306.
  102. Wolff L, Scolnick E, Ruscetti S. Envelope gene of the Friend spleen focus-forming virus: deletion and insertions in 3' gp70/p15E-encoding region have resulted in unique features in the primary structure of its protein product. Proc Natl Acad Sci U S A. 1983 Aug; 80(15):4718-22. PMID: 6308646; PMCID: PMC384115.
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  104. Anderson SM, Scolnick EM. Construction and isolation of a transforming murine retrovirus containing the src gene of Rous sarcoma virus. J Virol. 1983 May; 46(2):594-605. PMID: 6302322; PMCID: PMC255162.
  105. Bestwick R, Ruta M, Kiessling A, Faust C, Linemeyer D, Scolnick E, Kabat D. Genetic structure of Rauscher spleen focus-forming virus. J Virol. 1983 Mar; 45(3):1217-22. PMID: 6187943; PMCID: PMC256537.
  106. Ellis RW, DeFeo D, Papageorge A, Scolnick EM. Expression of endogenous p21 ras genes. Prog Clin Biol Res. 1983; 119:67-77. PMID: 6889382.
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  108. Sefton BM, Trowbridge IS, Cooper JA, Scolnick EM. The transforming proteins of Rous sarcoma virus, Harvey sarcoma virus and Abelson virus contain tightly bound lipid. Cell. 1982 Dec; 31(2 Pt 1):465-74. PMID: 6297767.
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  111. Ellis RW, DeFeo D, Furth ME, Scolnick EM. Mouse cells contain two distinct ras gene mRNA species that can be translated into a p21 onc protein. Mol Cell Biol. 1982 Nov; 2(11):1339-45. PMID: 6131379; PMCID: PMC369938.
  112. Dhar R, Ellis RW, Shih TY, Oroszlan S, Shapiro B, Maizel J, Lowy D, Scolnick E. Nucleotide sequence of the p21 transforming protein of Harvey murine sarcoma virus. Science. 1982 Sep 03; 217(4563):934-6. PMID: 6287572.
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  115. Linemeyer DL, Menke JG, Ruscetti SK, Evans LH, Scolnick EM. Envelope gene sequences which encode the gp52 protein of spleen focus-forming virus are required for the induction of erythroid cell proliferation. J Virol. 1982 Jul; 43(1):223-33. PMID: 6955527; PMCID: PMC256113.
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  148. Willingham MC, Pastan I, Shih TY, Scolnick EM. Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry. Cell. 1980 Apr; 19(4):1005-14. PMID: 6247068.
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  150. Chang HW, Garon CF, Chang EH, Lowy DR, Hager GL, Scolnick EM, Repaske R, Martin MA. Molecular cloning of the Harvey sarcoma virus circular DNA intermediates. II. Further structural analyses. J Virol. 1980 Feb; 33(2):845-55. PMID: 6251253; PMCID: PMC288610.
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  153. Evans L, Nunn M, Duesberg PH, Troxler D, Scolnick E. RNAs of defective and nondefective components of Friend anemia and polycythemia virus strains identified and compared. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 2,:823-35. PMID: 6933054.
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  154. Oliff AI, Hager GL, Chang EH, Scolnick EM, Chan HW, Lowy DR. Transfection of molecularly cloned Friend murine leukemia virus DNA yields a highly leukemogenic helper-independent type C virus. J Virol. 1980 Jan; 33(1):475-86. PMID: 6245244; PMCID: PMC288562.
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  156. Hager GL, Chang EH, Chan HW, Garon CF, Israel MA, Martin MA, Scolnick EM, Lowy DR. Molecular cloning of the Harvey sarcoma virus closed circular DNA intermediates: initial structural and biological characterization. J Virol. 1979 Sep; 31(3):795-809. PMID: 229252; PMCID: PMC353507.
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  158. Shih TY, Weeks MO, Young HA, Scolnick EM. p21 of Kirsten murine sarcoma virus is thermolabile in a viral mutant temperature sensitive for the maintenance of transformation. J Virol. 1979 Aug; 31(2):546-6. PMID: 225570; PMCID: PMC353477.
  159. Gillis S, Ruscetti SK, Gillis AE, Troxler DH, Scolnick EM, Smith KA. The spleen focus-forming virus (SFFV)-specific neoantigen shares cross-reactive determinants with mink cell focus-inducing (MCF) virus gp70. Virology. 1979 Jul 30; 96(2):421-8. PMID: 88803.
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  162. Frankel AE, Gilbert JH, Porzig KJ, Scolnick EM, Aaronson SA. Nature and distribution of feline sarcoma virus nucleotide sequences. J Virol. 1979 Jun; 30(3):821-7. PMID: 225544; PMCID: PMC353392.
  163. Ruscetti SK, Linemeyer D, Feild J, Troxler D, Scolnick EM. Characterization of a protein found in cells infected with the spleen focus-forming virus that shares immunological cross-reactivity with the gp70 found in mink cell focus-inducing virus particles. J Virol. 1979 Jun; 30(3):787-98. PMID: 90166; PMCID: PMC353389.
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  165. Young HA, Wenk ML, Goodman DG, Scolnick EM. Expression of RNA of an endogenous replication-defective retrovirus in rat mammary adenocarcinomas induced by 7,12-dimethylbenz[a]anthracene. J Natl Cancer Inst. 1978 Nov; 61(5):1329-37. PMID: 213614.
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  166. Kuff EL, Lueders KK, Scolnick EM. Nucleotide sequence relationship between intracisternal type A particles of Mus musculus and an endogenous retrovirus (M432) of Mus cervicolor. J Virol. 1978 Oct; 28(1):66-74. PMID: 212615; PMCID: PMC354248.
  167. Chien YH, Verma IM, Shih TY, Scolnick EM, Davidson N. Heteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses. J Virol. 1978 Oct; 28(1):352-60. PMID: 212606; PMCID: PMC354274.
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  173. Parks WP, Young HA, Scolnick EM. Eukaryotic gene regulation studies with mouse mammary tumor virus in tissue culture cells. Natl Cancer Inst Monogr. 1978 May; (48):215-8. PMID: 219353.
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  174. Shih TY, Weeks MO, Troxler DH, Coffin JM, Scolnick EM. Mapping host range-specific oligonucleotides within genomes of the ecotropic and mink cell focus-inducing strains of Moloney murine leukemia virus. J Virol. 1978 Apr; 26(1):71-83. PMID: 565826; PMCID: PMC354035.
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  176. Howk RS, Troxler DH, Lowy D, Duesberg PH, Scolnick EM. Identification of a 30S RNA with properties of a defective type C virus in murine cells. J Virol. 1978 Jan; 25(1):115-23. PMID: 202730; PMCID: PMC353907.
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  179. Duesberg PH, Scolnick EM. Murine leukemia viruses containing an approximately 30 S RNA subunit of unknown biological activity, in addition to the 38 S subunit of the viral genome. Virology. 1977 Nov; 83(1):211-6. PMID: 18625490.
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  182. Shih TY, Young HA, Parks WP, Scolnick EM. In vitro transcription of Moloney leukemia virus genes in infected cell nuclei and chromatin: elongation of chromatin associated ribonucleic acid by Escherichia coli ribonucleic acid polymerase. Biochemistry. 1977 May 03; 16(9):1795-801. PMID: 322707.
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  186. Scolnick EM, Williams D, Parks WP. Purification and characterisation of viral RNA of a sarcoma virus isolated from a woolly monkey. Nature. 1976 Dec 23-30; 264(5588):809-11. PMID: 189198.
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  188. Levin R, Ruscetti SK, Parks WP, Scolnick EM. Expression of feline type-C virus in normal and tumor tissues of the domestic cat. Int J Cancer. 1976 Nov 15; 18(5):661-71. PMID: 186414.
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  189. Holland JJ, Villarreal LP, Welsh RM, Oldstone MB, Kohne D, Lazzarini R, Scolnick E. Long-term persistent vesicular stomatitis virus and rabies virus infection of cells in vitro. J Gen Virol. 1976 Nov; 33(2):193-211. PMID: 186559.
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  192. Parks WP, Hubbell ES, Goldberg RJ, O'Neill FJ, Scolnick EM. High frequency variation in mammary tumor virus expression in cell culture. Cell. 1976 May; 8(1):87-93. PMID: 182380.
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  195. Scolnick EM, Young HA, Parks WP. Biochemical and physiological mechanisms in glucocorticoid hormone induction of mouse mammary tumor virus. Virology. 1976 Jan; 69(1):148-56. PMID: 174289.
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  198. Young HA, Parks WP, Scolnick EM. Effect of chemical inactivating agents on glucocorticoid receptor proteins in mouse and hamster cells. Proc Natl Acad Sci U S A. 1975 Aug; 72(8):3060-4. PMID: 171651; PMCID: PMC432919.
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  201. Parks WP, Ransom JC, Young HA, Scolnick EM. Mammary tumor virus induction by glucocorticoids. Characterization of specific transcriptional regulation. J Biol Chem. 1975 May 10; 250(9):3330-6. PMID: 47326.
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  202. Young HA, Scolnick EM, Parks WP. Glucocorticoid-receptor interaction and induction of murine mammary tumor virus. J Biol Chem. 1975 May 10; 250(9):3337-43. PMID: 164467.
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  203. Scolnick EM, Bumgarner SJ. Isolation of infectious xenotropic mouse type C virus by transfection of a heterologous cell with DNA from a transformed mouse cell. J Virol. 1975 May; 15(5):1293-6. PMID: 16789163.
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  206. Goldberg RJ, Scolnick EM, Parks WP, Yakovleva LA, Lapin BA. Isolation of a primate type-C virus from a lymphomatous baboon. Int J Cancer. 1974 Dec 15; 14(6):722-30. PMID: 4142786.
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  207. Scolnick EM, Maryak JM, Parks WP. Levels of rat cellular RNA homologous to either Kirsten sarcoma virus or rat type-C virus in cell lines derived from Osborne-Mendel rats. J Virol. 1974 Dec; 14(6):1435-44. PMID: 4372406; PMCID: PMC355672.
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  209. Howk RS, Williams DR, Haberman AB, Parks WP, Scolnick EM. A comparison of the transcription of mouse cell chromatin by homologous RNA polymerase I and II. Cell. 1974 Sep; 3(1):15-22. PMID: 4471968.
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  211. Scolnick EM, Parks WP. Harvey sarcoma virus: a second murine type C sarcoma virus with rat genetic information. J Virol. 1974 Jun; 13(6):1211-9. PMID: 4364897; PMCID: PMC355440.
  212. Scolnick EM, Parks WP. Host range studies on xenotropic type C viruses in somatic cell hybrids. Virology. 1974 May; 59(1):168-78. PMID: 4363582.
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  213. Parks WP, Scolnick EM, Kozikowski EH. Dexamethasone stimulation of murine mammary tumor virus expression: a tissue culture source of virus. Science. 1974 Apr 12; 184(4133):158-60. PMID: 4361099.
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  214. Scolnick EM, Parks W, Kawakami T, Kohne D, Okabe H, Gilden R, Hatanaka M. Primate and murine type-C viral nucleic acid association kinetics: analysis of model systems and natural tissues. J Virol. 1974 Feb; 13(2):363-9. PMID: 4359298; PMCID: PMC355305.
  215. Scolnick EM, Parks WP. Identification of viral reverse-transcriptase. Methods Enzymol. 1974; 29:130-43. PMID: 4136794.
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  216. Parks WP, Gilden RV, Bykovsky AF, Miller GG, Zhdanov VM, Soloviev VD, Scolnick EM. Mason-Pfizer virus characterization: a similar virus in a human amniotic cell line. J Virol. 1973 Dec; 12(6):1540-7. PMID: 4128382; PMCID: PMC356797.
  217. Benveniste RE, Todaro GJ, Scolnick EM, Parks WP. Partial transcription of murine type C viral genomes in BALB c cell lines. J Virol. 1973 Oct; 12(4):711-20. PMID: 4359949; PMCID: PMC356689.
  218. Scolnick EM, Rands E, Williams D, Parks WP. Studies on the nucleic acid sequences of Kirsten sarcoma virus: a model for formation of a mammalian RNA-containing sarcoma virus. J Virol. 1973 Sep; 12(3):458-63. PMID: 4127029; PMCID: PMC356651.
  219. Parks WP, Scolnick EM. Murine mammary tumor cell clones with varying degrees of virus expression. Virology. 1973 Sep; 55(1):163-73. PMID: 4353952.
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  220. Parks WP, Scolnick EM, Noon MC, Watson CJ, Kawakami TG. Radioimmunoassay of mammalian type-C polypeptides. IV. Characterization of woolly monkey and gibbon viral antigens. Int J Cancer. 1973 Jul 15; 12(1):129-37. PMID: 4133583.
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  221. Scolnick EM, Parks WP. Isolation and characterization of a primate sarcoma virus: mechanism of rescue. Int J Cancer. 1973 Jul 15; 12(1):138-47. PMID: 4364266.
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  222. Howk RS, Rye LA, Killeen LA, Scolnick EM, Parks WP. Characterization and separation of viral DNA polymerase in mouse milk. Proc Natl Acad Sci U S A. 1973 Jul; 70(7):2117-21. PMID: 4124683; PMCID: PMC433678.
  223. Scolnick EM, Benveniste R, Parks WP. Purification by oligo(dT)-cellulose of viral-specific RNA from sarcoma virus-transformed mammalian nonproducer cells. J Virol. 1973 Apr; 11(4):600-2. PMID: 4349497; PMCID: PMC355143.
  224. Parks WP, Livingston DM, Todaro GJ, Benveniste RE, Scolnick EM. Radioimmunoassay of mammalian type C viral proteins. 3. Detection of viral antigen in normal murine cells and tissues. J Exp Med. 1973 Mar 01; 137(3):622-35. PMID: 4347595; PMCID: PMC2139374.
  225. Benveniste RE, Scolnick EM. RNA in mammalian sarcoma virus transformed nonproducer cells homologous to murine leukemia virus RNA. Virology. 1973 Feb; 51(2):370-82. PMID: 4120907.
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  226. Todaro GJ, Scolnick EM, Parks WP, Livingston DM, Aaronson SA. Detection of type C viruses in normal and transformed cells. Johns Hopkins Med J Suppl. 1973; 2:231-44. PMID: 4137607.
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  227. Todaro GJ, Aaronson SA, Scolnick EM, Ross J, Parks WP. Reverse transcriptases of RNA tumor viruses: immunological relationships. Bibl Haematol. 1973; 39:269-71. PMID: 4130394.
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  228. Livingston DM, Parks WP, Scolnick EM, Ross J. Affinity chromatography of avian type C viral reverse transcriptase: studies with Rous sarcoma virus transformed rat cells. Virology. 1972 Nov; 50(2):388-95. PMID: 4117933.
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  229. Tronick SR, Scolnick EM, Parks WP. Reversible inactivation of the deoxyribonucleic acid polymerase of Rauscher leukemia virus. J Virol. 1972 Oct; 10(4):885-8. PMID: 4117352; PMCID: PMC356550.
  230. Scolnick EM, Stephenson JR, Aaronson SA. Isolation of temperature-sensitive mutants of murine sarcoma virus. J Virol. 1972 Oct; 10(4):653-7. PMID: 4117345; PMCID: PMC356516.
  231. Scolnick EM, Parks WP, Todaro GJ. Reverse transcriptases of primate viruses as immunological markers. Science. 1972 Sep 22; 177(4054):1119-21. PMID: 4115522.
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  232. Scolnick EM, Parks WP, Livingston DM. Radioimmunoassay of mammalian type C viral proteins. I. Species specific reactions of murine and feline viruses. J Immunol. 1972 Sep; 109(3):570-7. PMID: 4626657.
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  233. Ross J, Tronick SR, Scolnick EM. Polyadenylate rich RNA in the 70 S RNA of murine leukemia-sarcoma virus. Virology. 1972 Jul; 49(1):230-5. PMID: 4338992.
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  234. Parks WP, Scolnick EM. Radioimmunoassay of mammalian type-C viral proteins: interspecies antigenic reactivities of the major internal polypeptide. Proc Natl Acad Sci U S A. 1972 Jul; 69(7):1766-70. PMID: 4505653; PMCID: PMC426798.
  235. Stephenson JR, Scolnick EM, Aaronson SA. Genetic stability of the sarcoma viruses in murine and avian sarcoma virus-transformed nonproducer cells. Int J Cancer. 1972 May 15; 9(3):577-83. PMID: 4350125.
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  236. Livingston DM, Scolnick EM, Parks WP, Todaro GT. Affinity chromatography of RNA-dependent DNA polymerase from RNA tumor viruses on a solid phase immunoadsorbent. Proc Natl Acad Sci U S A. 1972 Feb; 69(2):393-7. PMID: 4333983; PMCID: PMC426465.
  237. Scolnick EM, Parks WP, Todaro GJ, Aaronson SA. Immunological characterization of primate C-type virus reverse transcriptases. Nat New Biol. 1972 Jan 12; 235(54):35-40. PMID: 4332802.
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  238. Ross J, Aviv H, Scolnick E, Leder P. In vitro synthesis of DNA complementary to purified rabbit globin mRNA (RNA-dependent DNA polymerase-reticulocyte-hemoglobin-density gradient centrifugation-oligo(dT) primer). Proc Natl Acad Sci U S A. 1972 Jan; 69(1):264-8. PMID: 4333043; PMCID: PMC427588.
  239. Parks WP, Scolnick EM, Ross J, Todaro GJ, Aaronson SA. Immunological relationships of reverse transcriptases from ribonucleic acid tumor viruses. J Virol. 1972 Jan; 9(1):110-5. PMID: 4333537; PMCID: PMC356269.
  240. Caskey CT, Beaudet AL, Scolnick EM, Rosman M. Hydrolysis of fMet-tRNA by peptidyl transferase. Proc Natl Acad Sci U S A. 1971 Dec; 68(12):3163-7. PMID: 4943558; PMCID: PMC389613.
  241. Aaronson SA, Todaro GJ, Scolnick EM. Induction of murine C-type viruses from clonal lines of virus-free BALB-3T3 cells. Science. 1971 Oct 08; 174(4005):157-9. PMID: 5119627.
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  242. Scolnick EM. "Reverse transcriptase" in higher cells. Dev Biol. 1971 Sep; 26(1):175-6. PMID: 5111766.
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  243. Ross J, Scolnick EM, Todaro GJ, Aaronson SA. Separation of murine cellular and murine leukaemia virus DNA polymerases. Nat New Biol. 1971 Jun 09; 231(23):163-7. PMID: 5281193.
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  244. Aaronson SA, Parks WP, Scolnick EM, Todaro GJ. Antibody to the RNA-dependent DNA polymerase of mammalian C-type RNA tumor viruses. Proc Natl Acad Sci U S A. 1971 May; 68(5):920-4. PMID: 4325004; PMCID: PMC389081.
  245. Scolnick EM, Aaronson SA, Todaro GJ, Parks WP. RNA dependent DNA polymerase activity in mammalian cells. Nature. 1971 Jan 29; 229(5283):318-21. PMID: 4993599.
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  246. Parks WP, Todaro GJ, Scolnick EM, Aaronson SA. RNA dependent DNA polymerase in primate syncytium-forming (foamy) viruses. Nature. 1971 Jan 22; 229(5282):258-60. PMID: 4323549.
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  247. Stone LB, Scolnick E, Takemoto KK, Aaronson SA. Visna virus: a slow virus with an RNA dependent DNA polymerase. Nature. 1971 Jan 22; 229(5282):257-8. PMID: 4994257.
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  248. Scolnick E, Rands E, Aaronson SA, Todaro GJ. RNA-dependent DNA polymerase activity in five RNA viruses: divalent cation requirements. Proc Natl Acad Sci U S A. 1970 Dec; 67(4):1789-96. PMID: 4322157; PMCID: PMC283428.
  249. Gerwin BI, Todaro GJ, Zeve V, Scolnick EM, Aaronson SA. Separation of RNA-dependent DNA polymerase activity from the murine leukaemia virion. Nature. 1970 Oct 31; 228(5270):435-8. PMID: 4320566.
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  250. Scolnick EM, Aaronson SA, Todaro GJ. DNA synthesis by RNA-containing tumor viruses. Proc Natl Acad Sci U S A. 1970 Oct; 67(2):1034-41. PMID: 4331715; PMCID: PMC283309.
  251. Tompkins RK, Scolnick EM, Caskey CT. Peptide chain termination. VII. The ribosomal and release factor requirements for peptide release. Proc Natl Acad Sci U S A. 1970 Mar; 65(3):702-8. PMID: 4910855; PMCID: PMC282963.
  252. Goldstein J, Milman G, Scolnick E, Caskey T. Peptide chain termination. VI. Purification and site of action of S. Proc Natl Acad Sci U S A. 1970 Feb; 65(2):430-7. PMID: 4905675; PMCID: PMC282921.
  253. Scolnick E, Milman G, Rosman M, Caskey T. Transesterification by peptidyl transferase. Nature. 1970 Jan 10; 225(5228):152-4. PMID: 5409961.
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  254. Scolnick EM, Caskey CT. Peptide chain termination. V. The role of release factors in mRNA terminator codon recognition. Proc Natl Acad Sci U S A. 1969 Dec; 64(4):1235-41. PMID: 4916922; PMCID: PMC223274.
  255. Scolnick EM, Caskey CT. Genetic punctuation signals. Lancet. 1969 Sep 13; 2(7620):597. PMID: 4185561.
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  256. Milman G, Goldstein J, Scolnick E, Caskey T. Peptide chain termination. 3. Stimulation of in vitro termination. Proc Natl Acad Sci U S A. 1969 May; 63(1):183-90. PMID: 4897024; PMCID: PMC534020.
  257. Pestka S, Scolnick EM, Heck BH. A convenient assay for mono-, di-, and oligophenylalanines. Anal Biochem. 1969 Apr 04; 28(1):375-84. PMID: 5781430.
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  258. Caskey T, Scolnick E, Tompkins R, Goldstein J, Milman G. Peptide chain termination, codon, protein factor, and ribosomal requirements. Cold Spring Harb Symp Quant Biol. 1969; 34:479-88. PMID: 4909515.
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  259. Caskey CT, Tompkins R, Scolnick E, Caryk T, Nirenberg M. Sequential translation of trinucleotide codons for the initiation and termination of protein synthesis. Science. 1968 Oct 04; 162(3849):135-8. PMID: 4877370.
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  260. Scolnick E, Tompkins R, Caskey T, Nirenberg M. Release factors differing in specificity for terminator codons. Proc Natl Acad Sci U S A. 1968 Oct; 61(2):768-74. PMID: 4879404; PMCID: PMC225226.
  261. Lang DJ, Scolnick EM, Willerson JT. Association of cytomegalovirus infection with the postperfusion syndrome. N Engl J Med. 1968 May 23; 278(21):1147-9. PMID: 4296525.
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  262. Deykin D, Pritzker CR, Scolnick EM. Plasma co-factors in adenosine diphosphate-induced aggregation of human platelets. Nature. 1965 Oct 16; 208(5007):296-8. PMID: 5882463.
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  263. SCOLNICK EM, LIN EC. Parallel induction of D-arabitol and D-sorbitol dehydrogenases. J Bacteriol. 1962 Oct; 84:631-7. PMID: 13992484; PMCID: PMC277938.
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