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James Sawalla Guseh, M.D.

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Dr. James Sawalla Guseh is a cardiovascular physician-scientist at Massachusetts General Hospital.

Dr. Guseh completed his undergraduate study at Harvard College (2006, Cambridge, MA) and obtained his medical doctorate (M.D.) from Harvard Medical School (2011). He would complete his Internal Medicine Residency (2014) and Chief Residency (2016 - 2017) at Massachusetts General Hospital and completed his Cardiology and Sports Cardiology training (2019) at Massachusetts General Hospital.

He is a faculty member of the Cardiology Division at Mass General and Harvard Medical School and he is a faculty member of the MGH Cardiovascular Performance Program. His clinical interests focus on the cardiovascular care of competitive and recreational athletes. Dr. Guseh has a fundamental and translational interest in the adaptive molecular mechanisms underlying cardiac remodeling and exercise-induced cardioprotection. Using proteomic and sequencing-based approaches, he investigates how beneficial adaptations from exercise might be therapeutically applied to disease states like heart failure.

Honors and awards include the Roman W. DeSanctis Clinical Scholar Award (2015), the American Heart Association Laennec Young Clinician Award (2018), and the Harvard Medical School John S. LaDue Memorial Fellowship (2018 - 2019). He is the inaugural Frisbie Family Scholar and his work is currently funded by the American Heart Association, the Harold Amos Medical Faculty Development Program and the MGH Physician-Scientist Development Program.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Guseh JS, Parakh A, Chen YE, Sundt TM, Fitzsimons MG, Stathatos N, Harris C. Case 40-2022: A 38-Year-Old Man with Exertional Chest Discomfort. N Engl J Med. 2022 12 29; 387(26):2450-2460. PMID: 36577103.
    Citations:    Fields:    Translation:Humans
  2. Grashow R, Shaffer-Pancyzk TV, Dairi I, Lee H, Marengi D, Baker J, Weisskopf MG, Speizer FE, Whittington AJ, Taylor HA, Keating D, Tenforde A, Guseh JS, Wasfy MM, Zafonte R, Baggish A. Healthspan and chronic disease burden among young adult and middle-aged male former American-style professional football players. Br J Sports Med. 2022 Dec 07. PMID: 36588423.
    Citations:    Fields:    
  3. Hastings MH, Herrera JJ, Guseh JS, Atlason B, Houstis NE, Abdul Kadir A, Li H, Sheffield C, Singh AP, Roh JD, Day SM, Rosenzweig A. Animal Models of Exercise From Rodents to Pythons. Circ Res. 2022 06 10; 130(12):1994-2014. PMID: 35679366; PMCID: PMC9202075.
    Citations:    Fields:    Translation:Animals
  4. Moulson N, Gustus SK, Scirica C, Petek BJ, Vanatta C, Churchill TW, Guseh JS, Baggish A, Wasfy MM. Diagnostic evaluation and cardiopulmonary exercise test findings in young athletes with persistent symptoms following COVID-19. Br J Sports Med. 2022 May 18. PMID: 35584886; PMCID: PMC9157326.
    Citations:    Fields:    
  5. Guseh JS, Jang IK. Exercise Intensity and Coronary Plaque Composition: Is Harder, Better, Faster, Stronger? J Am Heart Assoc. 2022 05 17; 11(10):e025991. PMID: 35574951; PMCID: PMC9238544.
    Citations:    Fields:    Translation:Humans
  6. Gustus S, Moulson N, Churchill TW, Guseh JS, Petek BJ, VanAtta C, Baggish AL, Wasfy MM. Impact of the COVID-19 pandemic on perceived cardiorespiratory fitness in athlete patients. PM R. 2022 05; 14(5):561-568. PMID: 35238166; PMCID: PMC9088663.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  7. Roh JD, Kitchen RR, Guseh JS, McNeill JN, Aid M, Martinot AJ, Yu A, Platt C, Rhee J, Weber B, Trager LE, Hastings MH, Ducat S, Xia P, Castro C, Singh A, Atlason B, Churchill TW, Di Carli MF, Ellinor PT, Barouch DH, Ho JE, Rosenzweig A. Plasma Proteomics of COVID-19-Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics. JACC Basic Transl Sci. 2022 May; 7(5):425-441. PMID: 35530264; PMCID: PMC9067411.
    Citations: 2     
  8. Stucky F, Churchill TW, Churchill JL, Petek BJ, Guseh JS, Wasfy MM, Kayser B, Baggish AL. Priming cardiac function with voluntary respiratory maneuvers and effect on early exercise oxygen uptake. J Appl Physiol (1985). 2022 05 01; 132(5):1179-1189. PMID: 35271410.
    Citations:    Fields:    Translation:Humans
  9. Rhee J, Kuznetsov A, McKay T, Lyons M, Houstis N, Mekkonen J, Ethridge B, Ibala R, Hahm E, Gitlin J, Guseh JS, Kitchen R, Rosenzweig A, Shaefi S, Flaczyk A, Qu J, Akeju O. Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium. Front Aging Neurosci. 2021; 13:699763. PMID: 34456709; PMCID: PMC8386117.
  10. Churchill TW, Petek BJ, Wasfy MM, Guseh JS, Weiner RB, Singh TK, Schmied C, O'Malley H, Chiampas G, Baggish AL. Cardiac Structure and Function in Elite Female and Male Soccer Players. JAMA Cardiol. 2021 03 01; 6(3):316-325. PMID: 33263734.
    Citations:    Fields:    Translation:Humans
  11. Frank RC, Mendez SR, Stevenson EK, Guseh JS, Chung M, Silverman MG. Obesity and the Risk of Intubation or Death in Patients With Coronavirus Disease 2019. Crit Care Med. 2020 11; 48(11):e1097-e1101. PMID: 33045152; PMCID: PMC7437410.
    Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
  12. Guseh JS, Churchill TW, Yeri A, Lo C, Brown M, Houstis NE, Aragam KG, Lieberman DE, Rosenzweig A, Baggish AL. An expanded repertoire of intensity-dependent exercise-responsive plasma proteins tied to loci of human disease risk. Sci Rep. 2020 07 02; 10(1):10831. PMID: 32616758.
    Citations: 5     Fields:    Translation:Humans
  13. Churchill TW, Groezinger E, Loomer G, Guseh JS, Weiner RB, Wasfy MM, Levine BD, Baggish AL. Training-Associated Changes in Ventricular Volumes and Function in Elite Female Runners. Circ Cardiovasc Imaging. 2020 06; 13(6):e010567. PMID: 32482135.
    Citations: 1     Fields:    Translation:Humans
  14. Churchill TW, Groezinger E, Kim JH, Loomer G, Guseh JS, Wasfy MM, Isselbacher EM, Lewis GD, Weiner RB, Schmied C, Baggish AL. Association of Ascending Aortic Dilatation and Long-term Endurance Exercise Among Older Masters-Level Athletes. JAMA Cardiol. 2020 05 01; 5(5):522-531. PMID: 32101252.
    Citations: 8     Fields:    Translation:Humans
  15. Gómez-Banoy N, Guseh JS, Li G, Rubio-Navarro A, Chen T, Poirier B, Putzel G, Rosselot C, Pabón MA, Camporez JP, Bhambhani V, Hwang SJ, Yao C, Perry RJ, Mukherjee S, Larson MG, Levy D, Dow LE, Shulman GI, Dephoure N, Garcia-Ocana A, Hao M, Spiegelman BM, Ho JE, Lo JC. Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans. Nat Med. 2019 11; 25(11):1739-1747. PMID: 31700183; PMCID: PMC7256970.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  16. Lau ES, Paniagua SM, Guseh JS, Bhambhani V, Zanni MV, Courchesne P, Lyass A, Larson MG, Levy D, Ho JE. Sex Differences in Circulating Biomarkers of Cardiovascular Disease. J Am Coll Cardiol. 2019 09 24; 74(12):1543-1553. PMID: 31537263; PMCID: PMC6756178.
    Citations: 31     Fields:    Translation:Humans
  17. Issa, Omar M.; Guseh, J. Sawalla; Inglessis, Ignacio and Baggish, Aaron L. Int. J. Cardiovasc. Sci. "Invasive Coronary Physiological Assessment in Symptomatic Middle-Aged Endurance Athletes". 2019; 32:326-330. View Publication.
  18. Knuesel SJ, Guseh JS, Karp Leaf R, Ciaranello AL, Eng GM. Case 6-2018: A 35-Year-Old Woman with Headache, Subjective Fever, and Anemia. N Engl J Med. 2018 Feb 22; 378(8):753-760. PMID: 29466149.
    Citations: 1     Fields:    Translation:HumansCells
  19. Guseh JS, Rosenzweig A. Size matters: Finding growth pathways that protect the heart. Cell Res. 2017 10; 27(10):1187-1188. PMID: 28925384; PMCID: PMC5630682.
    Citations: 2     Fields:    Translation:Humans
  20. Guseh JS. The Evolving Landscape of Exercise-Induced Pulmonary Hypertension. Curr Treat Options Cardiovasc Med. 2016 Jun; 18(6):41. PMID: 27174296.
  21. Guseh JS, Dudzinski DM. Acute Myocardial Infarction Due to Coronary Artery Embolus. J Interv Cardiol. 2015 Jun; 28(3):313-4. PMID: 25676716.
    Citations:    Fields:    Translation:Humans
  22. Guseh JS, Brendel RW, Brendel DH. Medical professionalism in the age of online social networking. J Med Ethics. 2009 Sep; 35(9):584-6. PMID: 19717700.
    Citations: 24     Fields:    Translation:Humans
  23. Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development. 2009 May; 136(10):1751-9. PMID: 19369400.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  24. Rajagopal J, Carroll TJ, Guseh JS, Bores SA, Blank LJ, Anderson WJ, Yu J, Zhou Q, McMahon AP, Melton DA. Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development. 2008 May; 135(9):1625-34. PMID: 18367557.
    Citations: 91     Fields:    Translation:AnimalsCells
  25. Anderson WJ, Zhou Q, Alcalde V, Kaneko OF, Blank LJ, Sherwood RI, Guseh JS, Rajagopal J, Melton DA. Genetic targeting of the endoderm with claudin-6CreER. Dev Dyn. 2008 Feb; 237(2):504-12. PMID: 18213590; PMCID: PMC2665265.
    Citations: 29     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.