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Shingo Kajimura, Ph.D.

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Mentoring
Available: 11/12/20, Expires: 10/31/25

Eukaryotic cells store metabolites in different organelles, a.k.a., subcellular metabolite compartmentalization. Distinct pools of metabolic enzymes and substrates provide another layer of flexibility in metabolite utilization, thereby allowing for robust adaptation to a variety of intrinsic and external changes. In turn, defects in the processes are associated with metabolic disorders, neurological diseases, aging, and cancer.

Our lab aims to uncover the regulatory mechanisms of subcellular metabolite fate with an emphasis on characterizing unknown mitochondrial metabolite transporters. Our lab is located at the Center for Life Sciences (CLS730) in the Division of Endocrinology, Diabetes & Metabolism, BIDMC. http://www.kajimuralab.org/


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK125283 (KAJIMURA, SHINGO) Dec 15, 2020 - Nov 30, 2024
    NIH
    Mitochondrial BCAA transporter in physiology and disease
    Role: Principal Investigator
  2. R01DK127575 (KAJIMURA, SHINGO) Sep 14, 2020 - Jun 30, 2025
    NIH
    Post-translational control of adipose tissue remodeling and metabolic health
    Role: Principal Investigator
  3. DP1DK126160 (KAJIMURA, SHINGO) Aug 1, 2020 - Jun 30, 2025
    NIH
    Mitochondrial metabolite compartmentalization in health and disease
    Role: Principal Investigator
  4. R01DK125281 (KAJIMURA, SHINGO) Jul 20, 2020 - Jun 30, 2024
    NIH
    Molecular control of beige fat heterogeneity
    Role: Principal Investigator
  5. R01DK112268 (KAJIMURA, SHINGO) Sep 20, 2016 - Jun 30, 2019
    NIH
    Biological roles and developmental pathway of burn-induced beige fat in humans
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ikeda K, Tajima K, Tanabe Y, Poon ASY, Kajimura S. Activation of UCP1-Independent Ca2+ Cycling Thermogenesis by Wireless Optogenetics. Methods Mol Biol. 2022; 2448:131-139. PMID: 35167095.
    Citations:    Fields:    Translation:HumansCells
  2. Yoshida N, Yamashita T, Osone T, Hosooka T, Shinohara M, Kitahama S, Sasaki K, Sasaki D, Yoneshiro T, Suzuki T, Emoto T, Saito Y, Ozawa G, Hirota Y, Kitaura Y, Shimomura Y, Okamatsu-Ogura Y, Saito M, Kondo A, Kajimura S, Inagaki T, Ogawa W, Yamada T, Hirata KI. Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity. iScience. 2021 Nov 19; 24(11):103342. PMID: 34805797.
    Citations: 1     
  3. Auger C, Kajimura S. Detouring adrenergic stimulation to induce adipose thermogenesis. Nat Rev Endocrinol. 2021 10; 17(10):579-580. PMID: 34326524.
    Citations: 1     Fields:    Translation:Humans
  4. Wang B, Tsakiridis EE, Zhang S, Llanos A, Desjardins EM, Yabut JM, Green AE, Day EA, Smith BK, Lally JSV, Wu J, Raphenya AR, Srinivasan KA, McArthur AG, Kajimura S, Patel JS, Wade MG, Morrison KM, Holloway AC, Steinberg GR. The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue. Nat Commun. 2021 08 27; 12(1):5163. PMID: 34453052.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  5. Chen CC, Chen BR, Wang Y, Curman P, Beilinson HA, Brecht RM, Liu CC, Farrell RJ, de Juan-Sanz J, Charbonnier LM, Kajimura S, Ryan TA, Schatz DG, Chatila TA, Wikstrom JD, Tyler JK, Sleckman BP. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination. J Exp Med. 2021 08 02; 218(8). PMID: 34033676.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Verkerke ARP, Kajimura S. Oil does more than light the lamp: The multifaceted role of lipids in thermogenic fat. Dev Cell. 2021 05 17; 56(10):1408-1416. PMID: 34004150.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M, Crown SB, Osawa T, Sakai J, McGarrah RW, White PJ, Nakamura K, Kajimura S. Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. Elife. 2021 05 04; 10. PMID: 33944778.
    Citations:    Fields:    Translation:AnimalsCells
  8. Kajimura S. The epigenetic regulation of adipose tissue plasticity. Proc Natl Acad Sci U S A. 2021 04 13; 118(15). PMID: 33741735.
    Citations:    Fields:    Translation:Humans
  9. Kajimura S. Bioenergetics matter to metabolic health-from a fat progenitor view. Cell Stem Cell. 2021 04 01; 28(4):589-591. PMID: 33798417.
    Citations:    Fields:    
  10. Cohen P, Kajimura S. The cellular and functional complexity of thermogenic fat. Nat Rev Mol Cell Biol. 2021 06; 22(6):393-409. PMID: 33758402.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  11. Walejko JM, Christopher BA, Crown SB, Zhang GF, Pickar-Oliver A, Yoneshiro T, Foster MW, Page S, van Vliet S, Ilkayeva O, Muehlbauer MJ, Carson MW, Brozinick JT, Hammond CD, Gimeno RE, Moseley MA, Kajimura S, Gersbach CA, Newgard CB, White PJ, McGarrah RW. Branched-chain a-ketoacids are preferentially reaminated and activate protein synthesis in the heart. Nat Commun. 2021 03 15; 12(1):1680. PMID: 33723250.
    Citations: 12     Fields:    Translation:AnimalsCells
  12. Conn CS, Yang H, Tom HJ, Ikeda K, Oses-Prieto JA, Vu H, Oguri Y, Nair S, Gill RM, Kajimura S, DeBerardinis RJ, Burlingame AL, Ruggero D. The major cap-binding protein eIF4E regulates lipid homeostasis and diet-induced obesity. Nat Metab. 2021 02; 3(2):244-257. PMID: 33619378.
    Citations: 2     Fields:    Translation:AnimalsCells
  13. Nabatame Y, Hosooka T, Aoki C, Hosokawa Y, Imamori M, Tamori Y, Okamatsu-Ogura Y, Yoneshiro T, Kajimura S, Saito M, Ogawa W. Kruppel-like factor 15 regulates fuel switching between glucose and fatty acids in brown adipocytes. J Diabetes Investig. 2021 Jul; 12(7):1144-1151. PMID: 33480176.
    Citations: 2     Fields:    Translation:AnimalsCells
  14. Verkerke ARP, Kajimura S. A new way to ignite thermogenesis in human adipose tissue. Nat Rev Endocrinol. 2020 09; 16(9):475-476. PMID: 32641836.
    Citations:    Fields:    Translation:HumansCells
  15. Sponton CH, Hosono T, Taura J, Jedrychowski MP, Yoneshiro T, Wang Q, Takahashi M, Matsui Y, Ikeda K, Oguri Y, Tajima K, Shinoda K, Pradhan RN, Chen Y, Brown Z, Roberts LS, Ward CC, Taoka H, Yokoyama Y, Watanabe M, Karasawa H, Nomura DK, Kajimura S. The regulation of glucose and lipid homeostasis via PLTP as a mediator of BAT-liver communication. EMBO Rep. 2020 09 03; 21(9):e49828. PMID: 32672883.
    Citations: 7     Fields:    Translation:Humans
  16. Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S. CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell. 2020 08 06; 182(3):563-577.e20. PMID: 32615086.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  17. Wang Z, Liu X, Liu M, Jiang K, Kajimura S, Kim H, Feeley BT. ß3-Adrenergic receptor agonist treats rotator cuff fatty infiltration by activating beige fat in mice. J Shoulder Elbow Surg. 2021 Feb; 30(2):373-386. PMID: 32599287.
    Citations: 2     Fields:    Translation:Animals
  18. Jun H, Ma Y, Chen Y, Gong J, Liu S, Wang J, Knights AJ, Qiao X, Emont MP, Xu XZS, Kajimura S, Wu J. Adrenergic-Independent Signaling via CHRNA2 Regulates Beige Fat Activation. Dev Cell. 2020 07 06; 54(1):106-116.e5. PMID: 32533922.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  19. Wang Z, Liu X, Jiang K, Kim H, Kajimura S, Feeley BT. Intramuscular Brown Fat Activation Decreases Muscle Atrophy and Fatty Infiltration and Improves Gait After Delayed Rotator Cuff Repair in Mice. Am J Sports Med. 2020 06; 48(7):1590-1600. PMID: 32282238.
    Citations: 3     Fields:    Translation:Animals
  20. Kajimura S, Spiegelman BM. Confounding issues in the "humanized" BAT of mice. Nat Metab. 2020; 2(4):303-304. PMID: 32405619.
    Citations: 4     Fields:    Translation:HumansAnimals
  21. Tajima K, Ikeda K, Tanabe Y, Thomson EA, Yoneshiro T, Oguri Y, Ferro MD, Poon ASY, Kajimura S. Wireless optogenetics protects against obesity via stimulation of non-canonical fat thermogenesis. Nat Commun. 2020 04 07; 11(1):1730. PMID: 32265443.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Oguri Y, Kajimura S. Cellular heterogeneity in brown adipose tissue. J Clin Invest. 2020 01 02; 130(1):65-67. PMID: 31763995.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Wang Q, Kajimura S. Naa10P puts a brake on PGC1a and fat browning. Nat Struct Mol Biol. 2019 10; 26(10):849-851. PMID: 31527714.
    Citations: 1     Fields:    
  24. Tajima K, Ikeda K, Chang HY, Chang CH, Yoneshiro T, Oguri Y, Jun H, Wu J, Ishihama Y, Kajimura S. Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. Nat Metab. 2019 09; 1(9):886-898. PMID: 32313871.
    Citations: 16     Fields:    Translation:AnimalsCells
  25. Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K, Dai Z, White PJ, McGarrah RW, Ilkayeva OR, Deleye Y, Oguri Y, Kuroda M, Ikeda K, Li H, Ueno A, Ohishi M, Ishikawa T, Kim K, Chen Y, Sponton CH, Pradhan RN, Majd H, Greiner VJ, Yoneshiro M, Brown Z, Chondronikola M, Takahashi H, Goto T, Kawada T, Sidossis L, Szoka FC, McManus MT, Saito M, Soga T, Kajimura S. BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature. 2019 08; 572(7771):614-619. PMID: 31435015.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  26. Dumesic PA, Egan DF, Gut P, Tran MT, Parisi A, Chatterjee N, Jedrychowski M, Paschini M, Kazak L, Wilensky SE, Dou F, Bogoslavski D, Cartier JA, Perrimon N, Kajimura S, Parikh SM, Spiegelman BM. An Evolutionarily Conserved uORF Regulates PGC1a and Oxidative Metabolism in Mice, Flies, and Bluefin Tuna. Cell Metab. 2019 07 02; 30(1):190-200.e6. PMID: 31105043.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  27. Chouchani ET, Kajimura S. Metabolic adaptation and maladaptation in adipose tissue. Nat Metab. 2019 02; 1(2):189-200. PMID: 31903450.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  28. Chen Y, Ikeda K, Yoneshiro T, Scaramozza A, Tajima K, Wang Q, Kim K, Shinoda K, Sponton CH, Brown Z, Brack A, Kajimura S. Thermal stress induces glycolytic beige fat formation via a myogenic state. Nature. 2019 01; 565(7738):180-185. PMID: 30568302.
    Citations: 68     Fields:    Translation:AnimalsCells
  29. Sponton CH, Kajimura S. AAV-mediated gene therapy as a strategy to fight obesity and metabolic diseases. EMBO Mol Med. 2018 08; 10(8). PMID: 30021799.
    Citations: 3     Fields:    Translation:HumansCells
  30. Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018 08; 560(7716):102-106. PMID: 30022159.
    Citations: 116     Fields:    Translation:AnimalsCells
  31. Sponton CH, Kajimura S. Multifaceted Roles of Beige Fat in Energy Homeostasis Beyond UCP1. Endocrinology. 2018 07 01; 159(7):2545-2553. PMID: 29757365.
    Citations: 10     Fields:    Translation:HumansAnimals
  32. Lu X, Altshuler-Keylin S, Wang Q, Chen Y, Henrique Sponton C, Ikeda K, Maretich P, Yoneshiro T, Kajimura S. Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism. Sci Signal. 2018 04 24; 11(527). PMID: 29692364.
    Citations: 46     Fields:    Translation:AnimalsCells
  33. Abe Y, Fujiwara Y, Takahashi H, Matsumura Y, Sawada T, Jiang S, Nakaki R, Uchida A, Nagao N, Naito M, Kajimura S, Kimura H, Osborne TF, Aburatani H, Kodama T, Inagaki T, Sakai J. Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch. Nat Commun. 2018 04 19; 9(1):1566. PMID: 29674659.
    Citations: 18     Fields:    Translation:AnimalsCells
  34. Tharp KM, Kang MS, Timblin GA, Dempersmier J, Dempsey GE, Zushin PH, Benavides J, Choi C, Li CX, Jha AK, Kajimura S, Healy KE, Sul HS, Saijo K, Kumar S, Stahl A. Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues. Cell Metab. 2018 03 06; 27(3):602-615.e4. PMID: 29514068.
    Citations: 20     Fields:    Translation:AnimalsCells
  35. Ikeda K, Maretich P, Kajimura S. The Common and Distinct Features of Brown and Beige Adipocytes. Trends Endocrinol Metab. 2018 03; 29(3):191-200. PMID: 29366777.
    Citations: 162     Fields:    Translation:HumansAnimalsCells
  36. Hasegawa Y, Ikeda K, Chen Y, Alba DL, Stifler D, Shinoda K, Hosono T, Maretich P, Yang Y, Ishigaki Y, Chi J, Cohen P, Koliwad SK, Kajimura S. Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis. Cell Metab. 2018 01 09; 27(1):180-194.e6. PMID: 29320702.
    Citations: 50     Fields:    Translation:AnimalsCells
  37. Ikeda K, Kang Q, Yoneshiro T, Camporez JP, Maki H, Homma M, Shinoda K, Chen Y, Lu X, Maretich P, Tajima K, Ajuwon KM, Soga T, Kajimura S. UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat Med. 2017 Dec; 23(12):1454-1465. PMID: 29131158.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  38. Fukunaka A, Fukada T, Bhin J, Suzuki L, Tsuzuki T, Takamine Y, Bin BH, Yoshihara T, Ichinoseki-Sekine N, Naito H, Miyatsuka T, Takamiya S, Sasaki T, Inagaki T, Kitamura T, Kajimura S, Watada H, Fujitani Y. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-ß expression. PLoS Genet. 2017 Aug; 13(8):e1006950. PMID: 28854265.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  39. Sponton CH, Kajimura S. Burning Fat and Building Bone by FSH Blockade. Cell Metab. 2017 08 01; 26(2):285-287. PMID: 28768167.
    Citations: 9     Fields:    Translation:Humans
  40. Choi SE, Kwon S, Seok S, Xiao Z, Lee KW, Kang Y, Li X, Shinoda K, Kajimura S, Kemper B, Kemper JK. Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver. Mol Cell Biol. 2017 08 01; 37(15). PMID: 28533219.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  41. Inagaki T, Sakai J, Kajimura S. Transcriptional and epigenetic control of brown and beige adipose cell fate and function. Nat Rev Mol Cell Biol. 2017 08; 18(8):527. PMID: 28698600.
    Citations: 9     Fields:    
  42. Bertholet AM, Kazak L, Chouchani ET, Bogaczynska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 2017 Apr 04; 25(4):811-822.e4. PMID: 28380374.
    Citations: 88     Fields:    Translation:AnimalsCells
  43. Sonne SB, Yadav R, Yin G, Dalgaard MD, Myrmel LS, Gupta R, Wang J, Madsen L, Kajimura S, Kristiansen K. Obesity is associated with depot-specific alterations in adipocyte DNA methylation and gene expression. Adipocyte. 2017 04 03; 6(2):124-133. PMID: 28481699.
    Citations: 13     Fields:    Translation:AnimalsCells
  44. Giordano A, Perugini J, Kristensen DM, Sartini L, Frontini A, Kajimura S, Kristiansen K, Cinti S. Mammary alveolar epithelial cells convert to brown adipocytes in post-lactating mice. J Cell Physiol. 2017 Nov; 232(11):2923-2928. PMID: 28191637.
    Citations: 6     Fields:    Translation:AnimalsCells
  45. Altshuler-Keylin S, Kajimura S. Mitochondrial homeostasis in adipose tissue remodeling. Sci Signal. 2017 02 28; 10(468). PMID: 28246203.
    Citations: 31     Fields:    Translation:HumansCells
  46. Kajimura S. Adipose tissue in 2016: Advances in the understanding of adipose tissue biology. Nat Rev Endocrinol. 2017 02; 13(2):69-70. PMID: 28051117.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  47. Kajimura S. PDGFA Makes Thin Skin Thicker: Molecular Regulation of Adipose Progenitor Maintenance. Cell Stem Cell. 2016 12 01; 19(6):675-676. PMID: 27912085.
    Citations:    Fields:    Translation:HumansCells
  48. Koh EH, Chen Y, Bader DA, Hamilton MP, He B, York B, Kajimura S, McGuire SE, Hartig SM. Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis. J Biol Chem. 2016 Nov 18; 291(47):24747-24755. PMID: 27758866.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  49. Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S. Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab. 2016 09 13; 24(3):402-419. PMID: 27568548.
    Citations: 120     Fields:    Translation:AnimalsCells
  50. Inagaki T, Sakai J, Kajimura S. Transcriptional and epigenetic control of brown and beige adipose cell fate and function. Nat Rev Mol Cell Biol. 2016 08; 17(8):480-95. PMID: 27251423.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  51. Chondronikola M, Volpi E, Børsheim E, Porter C, Saraf MK, Annamalai P, Yfanti C, Chao T, Wong D, Shinoda K, Labbe SM, Hurren NM, Cesani F, Kajimura S, Sidossis LS. Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans. Cell Metab. 2016 06 14; 23(6):1200-1206. PMID: 27238638.
    Citations: 97     Fields:    Translation:HumansCellsCTClinical Trials
  52. Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 2016 04; 22(4):427-32. PMID: 26950360.
    Citations: 187     Fields:    Translation:HumansCells
  53. Ohyama K, Nogusa Y, Shinoda K, Suzuki K, Bannai M, Kajimura S. A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. Diabetes. 2016 05; 65(5):1410-23. PMID: 26936964.
    Citations: 31     Fields:    Translation:AnimalsCells
  54. Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016 Mar 08; 23(3):454-66. PMID: 26876562.
    Citations: 60     Fields:    Translation:AnimalsCells
  55. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
    Citations: 2485     Fields:    Translation:HumansAnimals
  56. Shinoda K, Ohyama K, Hasegawa Y, Chang HY, Ogura M, Sato A, Hong H, Hosono T, Sharp LZ, Scheel DW, Graham M, Ishihama Y, Kajimura S. Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. Cell Metab. 2015 Dec 01; 22(6):997-1008. PMID: 26525534.
    Citations: 39     Fields:    Translation:AnimalsCells
  57. Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell. 2015 Oct 22; 163(3):643-55. PMID: 26496606.
    Citations: 263     Fields:    Translation:HumansAnimalsCells
  58. Güller I, McNaughton S, Crowley T, Gilsanz V, Kajimura S, Watt M, Russell AP. Comparative analysis of microRNA expression in mouse and human brown adipose tissue. BMC Genomics. 2015 Oct 19; 16:820. PMID: 26482036.
    Citations: 18     Fields:    Translation:HumansAnimals
  59. Kajimura S, Spiegelman BM, Seale P. Brown and Beige Fat: Physiological Roles beyond Heat Generation. Cell Metab. 2015 Oct 06; 22(4):546-59. PMID: 26445512.
    Citations: 349     Fields:    Translation:HumansAnimals
  60. Kajimura S. Promoting brown and beige adipocyte biogenesis through the PRDM16 pathway. Int J Obes Suppl. 2015 Aug; 5(Suppl 1):S11-4. PMID: 27152168.
    Citations: 9     
  61. Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J. JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis. Nat Commun. 2015 May 07; 6:7052. PMID: 25948511.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  62. Oh CM, Namkung J, Go Y, Shong KE, Kim K, Kim H, Park BY, Lee HW, Jeon YH, Song J, Shong M, Yadav VK, Karsenty G, Kajimura S, Lee IK, Park S, Kim H. Regulation of systemic energy homeostasis by serotonin in adipose tissues. Nat Commun. 2015 Apr 13; 6:6794. PMID: 25864946.
    Citations: 79     Fields:    Translation:AnimalsCells
  63. Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015 Apr; 21(4):389-94. PMID: 25774848.
    Citations: 192     Fields:    Translation:HumansAnimalsCells
  64. Sidossis L, Kajimura S. Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. J Clin Invest. 2015 Feb; 125(2):478-86. PMID: 25642708.
    Citations: 252     Fields:    Translation:HumansAnimals
  65. Kajimura S. Engineering Fat Cell Fate to Fight Obesity and Metabolic Diseases. Keio J Med. 2015; 64(4):65. PMID: 26727580.
    Citations: 6     Fields:    
  66. Ohyama K, Nogusa Y, Suzuki K, Shinoda K, Kajimura S, Bannai M. A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice. Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4):E315-23. PMID: 25516550.
    Citations: 15     Fields:    Translation:AnimalsCells
  67. Galmozzi A, Sonne SB, Altshuler-Keylin S, Hasegawa Y, Shinoda K, Luijten IHN, Chang JW, Sharp LZ, Cravatt BF, Saez E, Kajimura S. ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. Cell Rep. 2014 Dec 11; 9(5):1584-1593. PMID: 25466254.
    Citations: 47     Fields:    Translation:AnimalsCells
  68. Gridley T, Kajimura S. Lightening up a notch: Notch regulation of energy metabolism. Nat Med. 2014 Aug; 20(8):811-2. PMID: 25100522.
    Citations: 8     Fields:    Translation:Animals
  69. Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Jan 16; 156(1-2):304-16. PMID: 24439384.
    Citations: 367     Fields:    Translation:AnimalsCells
  70. Ohno H, Shinoda K, Ohyama K, Sharp LZ, Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013 Dec 05; 504(7478):163-7. PMID: 24196706.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  71. Kajimura S, Saito M. A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu Rev Physiol. 2014; 76:225-49. PMID: 24188710.
    Citations: 172     Fields:    Translation:HumansAnimalsCells
  72. Aune UL, Ruiz L, Kajimura S. Isolation and differentiation of stromal vascular cells to beige/brite cells. J Vis Exp. 2013 Mar 28; (73). PMID: 23568137.
    Citations: 64     Fields:    Translation:AnimalsCells
  73. Kang S, Akerblad P, Kiviranta R, Gupta RK, Kajimura S, Griffin MJ, Min J, Baron R, Rosen ED. Regulation of early adipose commitment by Zfp521. PLoS Biol. 2012; 10(11):e1001433. PMID: 23209378.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  74. Sharp LZ, Shinoda K, Ohno H, Scheel DW, Tomoda E, Ruiz L, Hu H, Wang L, Pavlova Z, Gilsanz V, Kajimura S. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One. 2012; 7(11):e49452. PMID: 23166672.
    Citations: 272     Fields:    Translation:HumansAnimals
  75. Gilsanz V, Hu HH, Kajimura S. Relevance of brown adipose tissue in infancy and adolescence. Pediatr Res. 2013 Jan; 73(1):3-9. PMID: 23090604.
    Citations: 36     Fields:    Translation:Humans
  76. Koncarevic A, Kajimura S, Cornwall-Brady M, Andreucci A, Pullen A, Sako D, Kumar R, Grinberg AV, Liharska K, Ucran JA, Howard E, Spiegelman BM, Seehra J, Lachey J. A novel therapeutic approach to treating obesity through modulation of TGFß signaling. Endocrinology. 2012 Jul; 153(7):3133-46. PMID: 22549226.
    Citations: 55     Fields:    Translation:HumansAnimals
  77. Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPAR? agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 2012 Mar 07; 15(3):395-404. PMID: 22405074.
    Citations: 316     Fields:    Translation:Animals
  78. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012 Jan 11; 481(7382):463-8. PMID: 22237023.
    Citations: 1449     Fields:    Translation:HumansAnimalsCells
  79. Kamei H, Ding Y, Kajimura S, Wells M, Chiang P, Duan C. Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability. Development. 2011 Feb; 138(4):777-86. PMID: 21266413.
    Citations: 29     Fields:    Translation:AnimalsCells
  80. Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest. 2011 Jan; 121(1):96-105. PMID: 21123942.
    Citations: 537     Fields:    Translation:Animals
  81. Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature. 2010 Jul 22; 466(7305):451-6. PMID: 20651683.
    Citations: 385     Fields:    Translation:HumansAnimalsCells
  82. Kajimura S, Seale P, Spiegelman BM. Transcriptional control of brown fat development. Cell Metab. 2010 Apr 07; 11(4):257-62. PMID: 20374957.
    Citations: 173     Fields:    Translation:Humans
  83. Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009 Aug 27; 460(7259):1154-8. PMID: 19641492.
    Citations: 319     Fields:    Translation:HumansAnimalsCells
  84. Seale P, Kajimura S, Spiegelman BM. Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev. 2009 Apr 01; 23(7):788-97. PMID: 19339685.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  85. Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. J Biol Chem. 2008 Nov 14; 283(46):31960-7. PMID: 18728005.
    Citations: 28     Fields:    Translation:AnimalsCells
  86. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21; 454(7207):961-7. PMID: 18719582.
    Citations: 947     Fields:    Translation:AnimalsCells
  87. Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008 May 15; 22(10):1397-409. PMID: 18483224.
    Citations: 218     Fields:    Translation:AnimalsCells
  88. Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007 Jul; 6(1):38-54. PMID: 17618855.
    Citations: 473     Fields:    Translation:AnimalsCells
  89. Takahashi H, Prunet P, Kitahashi T, Kajimura S, Hirano T, Grau EG, Sakamoto T. Prolactin receptor and proliferating/apoptotic cells in esophagus of the Mozambique tilapia (Oreochromis mossambicus) in fresh water and in seawater. Gen Comp Endocrinol. 2007 Jun-Jul; 152(2-3):326-31. PMID: 17418192.
    Citations: 3     Fields:    Translation:AnimalsCells
  90. Kajimura S, Aida K, Duan C. Understanding hypoxia-induced gene expression in early development: in vitro and in vivo analysis of hypoxia-inducible factor 1-regulated zebra fish insulin-like growth factor binding protein 1 gene expression. Mol Cell Biol. 2006 Feb; 26(3):1142-55. PMID: 16428465.
    Citations: 47     Fields:    Translation:AnimalsCells
  91. Kajimura S, Seale AP, Hirano T, Cooke IM, Grau EG. Physiological concentrations of ouabain rapidly inhibit prolactin release from the tilapia pituitary. Gen Comp Endocrinol. 2005 Sep 15; 143(3):240-50. PMID: 15922343.
    Citations: 4     Fields:    Translation:Animals
  92. Kajimura S, Aida K, Duan C. Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1240-5. PMID: 15644436.
    Citations: 71     Fields:    Translation:AnimalsCells
  93. Kajimura S, Kawaguchi N, Kaneko T, Kawazoe I, Hirano T, Visitacion N, Grau EG, Aida K. Identification of the growth hormone receptor in an advanced teleost, the tilapia (Oreochromis mossambicus) with special reference to its distinct expression pattern in the ovary. J Endocrinol. 2004 Apr; 181(1):65-76. PMID: 15072567.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  94. Kajimura S, Hirano T, Moriyama S, Vakkuri O, Leppäluoto J, Grau EG. Changes in plasma concentrations of immunoreactive ouabain in the tilapia in response to changing salinity: is ouabain a hormone in fish? Gen Comp Endocrinol. 2004 Jan 01; 135(1):90-9. PMID: 14644648.
    Citations: 2     Fields:    Translation:Animals
  95. Uchida K, Yoshikawa-Ebesu JS, Kajimura S, Yada T, Hirano T, Gordon Grau E. In vitro effects of cortisol on the release and gene expression of prolactin and growth hormone in the tilapia, Oreochromis mossambicus. Gen Comp Endocrinol. 2004 Jan 01; 135(1):116-25. PMID: 14644651.
    Citations: 3     Fields:    Translation:Animals
  96. Kajimura S, Hirano T, Visitacion N, Moriyama S, Aida K, Grau EG. Dual mode of cortisol action on GH/IGF-I/IGF binding proteins in the tilapia, Oreochromis mossambicus. J Endocrinol. 2003 Jul; 178(1):91-9. PMID: 12844340.
    Citations: 15     Fields:    Translation:Animals
  97. Uchida K, Kajimura S, Riley LG, Hirano T, Aida K, Grau EG. Effects of fasting on growth hormone/insulin-like growth factor I axis in the tilapia, Oreochromis mossambicus. Comp Biochem Physiol A Mol Integr Physiol. 2003 Feb; 134(2):429-39. PMID: 12547273.
    Citations: 16     Fields:    Translation:Animals
  98. Seale AP, Riley LG, Leedom TA, Kajimura S, Dores RM, Hirano T, Grau EG. Effects of environmental osmolality on release of prolactin, growth hormone and ACTH from the tilapia pituitary. Gen Comp Endocrinol. 2002 Sep; 128(2):91-101. PMID: 12392682.
    Citations: 19     Fields:    Translation:Animals
  99. Kajimura S, Uchida K, Yada T, Hirano T, Aida K, Gordon Grau E. Effects of insulin-like growth factors (IGF-I and -II) on growth hormone and prolactin release and gene expression in euryhaline tilapia, Oreochromis mossambicus. Gen Comp Endocrinol. 2002 Jul; 127(3):223-31. PMID: 12225763.
    Citations: 4     Fields:    Translation:Animals
  100. Yada T, Uchida K, Kajimura S, Azuma T, Hirano T, Grau EG. Immunomodulatory effects of prolactin and growth hormone in the tilapia, Oreochromis mossambicus. J Endocrinol. 2002 Jun; 173(3):483-92. PMID: 12065238.
    Citations: 5     Fields:    Translation:AnimalsCells
  101. Kajimura S, Yoshiura Y, Suzuki M, Aida K. cDNA cloning of two gonadotropin beta subunits (GTH-Ibeta and -IIbeta) and their expression profiles during gametogenesis in the Japanese flounder (Paralichthys olivaceus). Gen Comp Endocrinol. 2001 May; 122(2):117-29. PMID: 11316417.
    Citations: 9     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.