Harvard Catalyst Profiles

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Collin Melveton Stultz, M.D.,Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13AR064585 (STULTZ, COLLIN M) May 16, 2013 - Apr 30, 2014
    2013 Collagen Gordon Research Conference and Gordon Research Seminar
    Role: Principal Investigator
  2. R21NS063185 (STULTZ, COLLIN M) May 15, 2009 - Apr 30, 2012
    Structure-based Ligand Design of Inhibitors that Prevent Tau Aggregation
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dai W, Nazzari H, Namasivayam M, Hung J, Stultz CM. Identifying Aortic Stenosis With a Single Parasternal Long-Axis Video Using Deep Learning. J Am Soc Echocardiogr. 2023 Jan; 36(1):116-118. PMID: 36323367.
    Citations:    Fields:    Translation:Humans
  2. Namasivayam M, Myers PD, Guttag JV, Capoulade R, Pibarot P, Picard MH, Hung J, Stultz CM. Predicting outcomes in patients with aortic stenosis using machine learning: the Aortic Stenosis Risk (ASteRisk) score. Open Heart. 2022 05; 9(1). PMID: 35641101; PMCID: PMC9157386.
    Citations:    Fields:    Translation:Humans
  3. Diamant N, Reinertsen E, Song S, Aguirre AD, Stultz CM, Batra P. Patient contrastive learning: A performant, expressive, and practical approach to electrocardiogram modeling. PLoS Comput Biol. 2022 02; 18(2):e1009862. PMID: 35157695; PMCID: PMC8880931.
    Citations: 1     Fields:    Translation:Humans
  4. Morales MA, van den Boomen M, Nguyen C, Kalpathy-Cramer J, Rosen BR, Stultz CM, Izquierdo-Garcia D, Catana C. DeepStrain: A Deep Learning Workflow for the Automated Characterization of Cardiac Mechanics. Front Cardiovasc Med. 2021; 8:730316. PMID: 34540923; PMCID: PMC8446607.
    Citations: 2     
  5. Stultz C. Editorial commentary: Deep learning in cardiology: All models are wrong, but some are useful. Trends Cardiovasc Med. 2022 01; 32(1):42-43. PMID: 33338637.
    Citations:    Fields:    Translation:Humans
  6. Myers PD, Ng K, Severson K, Kartoun U, Dai W, Huang W, Anderson FA, Stultz CM. Identifying unreliable predictions in clinical risk models. NPJ Digit Med. 2020 Jan 23; 3(1):8. PMID: 33479434.
  7. Myers PD, Ng K, Severson K, Kartoun U, Dai W, Huang W, Anderson FA, Stultz CM. Identifying unreliable predictions in clinical risk models. NPJ Digit Med. 2020; 3:8. PMID: 31993506.
    Citations: 2     
  8. Myers PD, Huang W, Anderson F, Stultz CM. Choosing Clinical Variables for Risk Stratification Post-Acute Coronary Syndrome. Sci Rep. 2019 10 10; 9(1):14631. PMID: 31601916.
    Citations: 3     Fields:    Translation:Humans
  9. Bowman SEJ, Backman LRF, Bjork RE, Andorfer MC, Yori S, Caruso A, Stultz CM, Drennan CL. Solution structure and biochemical characterization of a spare part protein that restores activity to an oxygen-damaged glycyl radical enzyme. J Biol Inorg Chem. 2019 09; 24(6):817-829. PMID: 31250200; PMCID: PMC6754787.
    Citations: 7     Fields:    Translation:Cells
  10. Stultz CM. The Advent of Clinically Useful Deep Learning. JACC Clin Electrophysiol. 2019 05; 5(5):587-589. PMID: 31122380.
    Citations: 2     Fields:    
  11. Myers PD, Scirica BM, Stultz CM. Machine Learning Improves Risk Stratification After Acute Coronary Syndrome. Sci Rep. 2017 10 04; 7(1):12692. PMID: 28978948.
    Citations: 12     Fields:    Translation:Humans
  12. Burger VM, Vandervelde A, Hendrix J, Konijnenberg A, Sobott F, Loris R, Stultz CM. Hidden States within Disordered Regions of the CcdA Antitoxin Protein. J Am Chem Soc. 2017 02 22; 139(7):2693-2701. PMID: 28124913.
    Citations: 3     Fields:    Translation:Cells
  13. Liu Y, Scirica BM, Stultz CM, Guttag JV. Beatquency domain and machine learning improve prediction of cardiovascular death after acute coronary syndrome. Sci Rep. 2016 10 06; 6:34540. PMID: 27708350.
    Citations: 7     Fields:    Translation:Humans
  14. Burger VM, Arenas DJ, Stultz CM. A Structure-free Method for Quantifying Conformational Flexibility in proteins. Sci Rep. 2016 06 30; 6:29040. PMID: 27358108.
    Citations: 12     Fields:    Translation:Cells
  15. Ziegler Z, Schmidt M, Gurry T, Burger V, Stultz CM. Mollack: a web server for the automated creation of conformational ensembles for intrinsically disordered proteins. Bioinformatics. 2016 08 15; 32(16):2545-7. PMID: 27153636.
    Citations: 1     Fields:    Translation:Cells
  16. Burger VM, Nolasco DO, Stultz CM. Expanding the Range of Protein Function at the Far End of the Order-Structure Continuum. J Biol Chem. 2016 Mar 25; 291(13):6706-13. PMID: 26851282.
    Citations: 8     Fields:    Translation:HumansCells
  17. Gurry T, Fisher CK, Schmidt M, Stultz CM. Analyzing Ensembles of Amyloid Proteins Using Bayesian Statistics. Methods Mol Biol. 2016; 1345:269-80. PMID: 26453218.
    Citations:    Fields:    Translation:HumansCells
  18. DaSilva LC, Gurry T, Stultz CM. Toward a consensus in protein structure nomenclature. Intrinsically Disord Proteins. 2014; 2(1):e970902. PMID: 28232882; PMCID: PMC5314908.
  19. Gurry T, Stultz CM. Mechanism of amyloid-ß fibril elongation. Biochemistry. 2014 Nov 11; 53(44):6981-91. PMID: 25330398.
    Citations: 28     Fields:    Translation:HumansCells
  20. Zhong C, Gurry T, Cheng AA, Downey J, Deng Z, Stultz CM, Lu TK. Strong underwater adhesives made by self-assembling multi-protein nanofibres. Nat Nanotechnol. 2014 Oct; 9(10):858-66. PMID: 25240674.
    Citations: 87     Fields:    Translation:AnimalsCells
  21. Liu Y, Syed Z, Scirica BM, Morrow DA, Guttag JV, Stultz CM. ECG morphological variability in beat space for risk stratification after acute coronary syndrome. J Am Heart Assoc. 2014 Jun 24; 3(3):e000981. PMID: 24963105.
    Citations: 6     Fields:    Translation:Humans
  22. Gee EPS, Yüksel D, Stultz CM, Ingber DE. SLLISWD sequence in the 10FNIII domain initiates fibronectin fibrillogenesis. J Biol Chem. 2013 Jul 19; 288(29):21329-21340. PMID: 23740248.
    Citations: 10     Fields:    Translation:HumansCells
  23. Fisher CK, Ullman O, Stultz CM. Comparative studies of disordered proteins with similar sequences: application to Aß40 and Aß42. Biophys J. 2013 Apr 02; 104(7):1546-55. PMID: 23561531.
    Citations: 9     Fields:    Translation:Cells
  24. Gurry T, Ullman O, Fisher CK, Perovic I, Pochapsky T, Stultz CM. The dynamic structure of a-synuclein multimers. J Am Chem Soc. 2013 Mar 13; 135(10):3865-72. PMID: 23398399.
    Citations: 50     Fields:    Translation:Cells
  25. Lu KG, Stultz CM. Insight into the degradation of type-I collagen fibrils by MMP-8. J Mol Biol. 2013 May 27; 425(10):1815-25. PMID: 23399546.
    Citations: 19     Fields:    Translation:AnimalsCells
  26. Liu JS, Schubert CR, Fu X, Fourniol FJ, Jaiswal JK, Houdusse A, Stultz CM, Moores CA, Walsh CA. Molecular basis for specific regulation of neuronal kinesin-3 motors by doublecortin family proteins. Mol Cell. 2012 Sep 14; 47(5):707-21. PMID: 22857951; PMCID: PMC3549492.
    Citations: 60     Fields:    Translation:AnimalsCells
  27. Walker S, Ullman O, Stultz CM. Using intramolecular disulfide bonds in tau protein to deduce structural features of aggregation-resistant conformations. J Biol Chem. 2012 Mar 16; 287(12):9591-600. PMID: 22291015.
    Citations: 12     Fields:    Translation:HumansCells
  28. Fisher CK, Ullman O, Stultz CM. Efficient construction of disordered protein ensembles in a Bayesian framework with optimal selection of conformations. Pac Symp Biocomput. 2012; 82-93. PMID: 22174265.
    Citations: 7     Fields:    Translation:HumansCells
  29. Ullman O, Fisher CK, Stultz CM. Explaining the structural plasticity of a-synuclein. J Am Chem Soc. 2011 Dec 07; 133(48):19536-46. PMID: 22029383.
    Citations: 47     Fields:    Translation:HumansCells
  30. Syed Z, Stultz CM, Scirica BM, Guttag JV. Computationally generated cardiac biomarkers for risk stratification after acute coronary syndrome. Sci Transl Med. 2011 Sep 28; 3(102):102ra95. PMID: 21957173.
    Citations: 8     Fields:    Translation:Humans
  31. Fisher CK, Stultz CM. Protein structure along the order-disorder continuum. J Am Chem Soc. 2011 Jul 06; 133(26):10022-5. PMID: 21650183.
    Citations: 15     Fields:    Translation:HumansCells
  32. Fisher CK, Stultz CM. Constructing ensembles for intrinsically disordered proteins. Curr Opin Struct Biol. 2011 Jun; 21(3):426-31. PMID: 21530234.
    Citations: 99     Fields:    Translation:Cells
  33. Chen MM, Bartlett AI, Nerenberg PS, Friel CT, Hackenberger CP, Stultz CM, Radford SE, Imperiali B. Perturbing the folding energy landscape of the bacterial immunity protein Im7 by site-specific N-linked glycosylation. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22528-33. PMID: 21148421.
    Citations: 25     Fields:    Translation:Cells
  34. Fisher CK, Huang A, Stultz CM. Modeling intrinsically disordered proteins with bayesian statistics. J Am Chem Soc. 2010 Oct 27; 132(42):14919-27. PMID: 20925316.
    Citations: 59     Fields:    
  35. Phillips CM, Schreiter ER, Stultz CM, Drennan CL. Structural basis of low-affinity nickel binding to the nickel-responsive transcription factor NikR from Escherichia coli. Biochemistry. 2010 Sep 14; 49(36):7830-8. PMID: 20704276.
    Citations: 10     Fields:    Translation:Cells
  36. Phillips CM, Stultz CM, Drennan CL. Searching for the Nik operon: how a ligand-responsive transcription factor hunts for its DNA binding site. Biochemistry. 2010 Sep 14; 49(36):7757-63. PMID: 20712334.
    Citations: 2     Fields:    Translation:Cells
  37. Gurry T, Nerenberg PS, Stultz CM. The contribution of interchain salt bridges to triple-helical stability in collagen. Biophys J. 2010 Jun 02; 98(11):2634-43. PMID: 20513408.
    Citations: 10     Fields:    Translation:Cells
  38. Salsas-Escat R, Nerenberg PS, Stultz CM. Cleavage site specificity and conformational selection in type I collagen degradation. Biochemistry. 2010 May 18; 49(19):4147-58. PMID: 20394413.
    Citations: 14     Fields:    Translation:Cells
  39. Salsas-Escat R, Stultz CM. Conformational selection and collagenolysis in type III collagen. Proteins. 2010 Feb 01; 78(2):325-35. PMID: 19731369.
    Citations: 11     Fields:    Translation:HumansCells
  40. Syed Z, Stultz C, Kellis M, Indyk P, Guttag J. Motif Discovery in Physiological Datasets: A Methodology for Inferring Predictive Elements. ACM Trans Knowl Discov Data. 2010 Jan; 4(1):2. PMID: 20730037.
    Citations: 4     
  41. Phillips CM, Nerenberg PS, Drennan CL, Stultz CM. Physical basis of metal-binding specificity in Escherichia coli NikR. J Am Chem Soc. 2009 Jul 29; 131(29):10220-8. PMID: 19621966; PMCID: PMC3579654.
    Citations: 6     Fields:    Translation:Cells
  42. Schubert CR, Stultz CM. The multi-copy simultaneous search methodology: a fundamental tool for structure-based drug design. J Comput Aided Mol Des. 2009 Aug; 23(8):475-89. PMID: 19506805.
    Citations: 9     Fields:    Translation:HumansCells
  43. Huang A, Stultz CM. Finding order within disorder: elucidating the structure of proteins associated with neurodegenerative disease. Future Med Chem. 2009 Jun; 1(3):467-82. PMID: 21426127.
    Citations: 14     Fields:    Translation:HumansCells
  44. Syed Z, Sung P, Scirica BM, Morrow DA, Stultz CM, Guttag JV. Spectral energy of ECG morphologic differences to predict death. Cardiovasc Eng. 2009 Mar; 9(1):18-26. PMID: 19283476.
    Citations: 2     Fields:    Translation:Humans
  45. Yoon MK, Venkatachalam V, Huang A, Choi BS, Stultz CM, Chou JJ. Residual structure within the disordered C-terminal segment of p21(Waf1/Cip1/Sdi1) and its implications for molecular recognition. Protein Sci. 2009 Feb; 18(2):337-47. PMID: 19165719.
    Citations: 18     Fields:    Translation:HumansCells
  46. Syed Z, Scirica BM, Mohanavelu S, Sung P, Michelson EL, Cannon CP, Stone PH, Stultz CM, Guttag JV. Relation of death within 90 days of non-ST-elevation acute coronary syndromes to variability in electrocardiographic morphology. Am J Cardiol. 2009 Feb 01; 103(3):307-11. PMID: 19166680.
    Citations: 6     Fields:    Translation:Humans
  47. Huang A, Stultz CM. The effect of a DeltaK280 mutation on the unfolded state of a microtubule-binding repeat in Tau. PLoS Comput Biol. 2008 Aug 22; 4(8):e1000155. PMID: 18725924.
    Citations: 19     Fields:    Translation:HumansCells
  48. Nerenberg PS, Stultz CM. Differential unfolding of alpha1 and alpha2 chains in type I collagen and collagenolysis. J Mol Biol. 2008 Sep 26; 382(1):246-56. PMID: 18644377.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  49. Gee EP, Ingber DE, Stultz CM. Fibronectin unfolding revisited: modeling cell traction-mediated unfolding of the tenth type-III repeat. PLoS One. 2008; 3(6):e2373. PMID: 19020673.
    Citations: 29     Fields:    Translation:HumansCells
  50. Nerenberg PS, Salsas-Escat R, Stultz CM. Do collagenases unwind triple-helical collagen before peptide bond hydrolysis? Reinterpreting experimental observations with mathematical models. Proteins. 2008 Mar; 70(4):1154-61. PMID: 17932911.
    Citations: 19     Fields:    Translation:Cells
  51. Nerenberg PS, Salsas-Escat R, Stultz CM. Collagen--a necessary accomplice in the metastatic process. Cancer Genomics Proteomics. 2007 Sep-Oct; 4(5):319-28. PMID: 17993716.
    Citations: 14     Fields:    Translation:HumansAnimals
  52. Thomas AH, Edelman ER, Stultz CM. Collagen fragments modulate innate immunity. Exp Biol Med (Maywood). 2007 Mar; 232(3):406-11. PMID: 17327474.
    Citations: 23     Fields:    Translation:HumansCells
  53. Huang A, Stultz CM. Conformational sampling with implicit solvent models: application to the PHF6 peptide in tau protein. Biophys J. 2007 Jan 01; 92(1):34-45. PMID: 17040986; PMCID: PMC1697846.
    Citations: 8     Fields:    Translation:HumansCells
  54. Stultz CM. The folding mechanism of collagen-like model peptides explored through detailed molecular simulations. Protein Sci. 2006 Sep; 15(9):2166-77. PMID: 16943446; PMCID: PMC2242609.
    Citations: 6     Fields:    Translation:Cells
  55. Stultz CM. An Assessment of Potential of Mean Force Calculations with Implicit Solvent Models. J. Chem. Phys B. 2004; 108:16525-16532.
  56. Stultz CM, Edelman ER. A structural model that explains the effects of hyperglycemia on collagenolysis. Biophys J. 2003 Oct; 85(4):2198-204. PMID: 14507685; PMCID: PMC1303446.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  57. Stultz CM, Levin AD, Edelman ER. Phosphorylation-induced conformational changes in a mitogen-activated protein kinase substrate. Implications for tyrosine hydroxylase activation. J Biol Chem. 2002 Dec 06; 277(49):47653-61. PMID: 12361946.
    Citations: 11     Fields:    Translation:AnimalsCells
  58. Stultz CM. Localized unfolding of collagen explains collagenase cleavage near imino-poor sites. J Mol Biol. 2002 Jun 21; 319(5):997-1003. PMID: 12079342.
    Citations: 35     Fields:    Translation:HumansCells
  59. Stultz CM, Levin AD, Edelman ER. A Structural Model that Explains the Effects of Hyperglycemia on Collagenolysis. J. Biol. Chem. 2002; 277:47653-47661.
  60. Stultz CM, Karplus M. Dynamic ligand design and combinatorial optimization: designing inhibitors to endothiapepsin. Proteins. 2000 Aug 01; 40(2):258-89. PMID: 10842341.
    Citations: 10     Fields:    Translation:Cells
  61. Stultz CM, Karplus M. Dynamic Ligand Design and Combinatorial Optimization. Proteins, Structure Function and Genetics. 2000; 40:259-289.
  62. Stultz CM, Karplus M. MCSS functionality maps for a flexible protein. Proteins. 1999 Dec 01; 37(4):512-29. PMID: 10651268.
    Citations: 10     Fields:    Translation:Cells
  63. Stultz CM, Karplus M. MCSS Functionality Maps for a Flexible Protein. Proteins, Structure Function and Gentetics. 1999; 37:512-529.
  64. Stultz CM, Karplus M. On the Potential Surface of the Locally Enhanced Sampling Approximation. Journal of Chemical Physics. 1998; 109:8809-8815.
  65. Stultz CM. Predicting Protein Structure with Probabilistic Models. 1997.
  66. Stultz CM, Nambudripad R, Lathrop R, White JV . Predicting Protein Structure with Probabilistic Models. Protein Structural Biology in Bio-Medical Research , Vol. 22B of Advances in Molecular and Cell Biology series editor: E. E. Bittar, Guest Editors: N.M. Allewell and C. Woodward. 1997; 447-506.
  67. Stultz CM. Studies in Structure Based Drug Design: Ligand Design with a Flexible Protein . 1997.
  68. White JV, Stultz CM, Smith TF. Protein classification by stochastic modeling and optimal filtering of amino-acid sequences. Math Biosci. 1994 Jan; 119(1):35-75. PMID: 8111135.
    Citations: 37     Fields:    Translation:Cells
  69. Stultz CM, White JV, Smith TF. Structural analysis based on state-space modeling. Protein Sci. 1993 Mar; 2(3):305-14. PMID: 8453370; PMCID: PMC2142382.
    Citations: 45     Fields:    Translation:Cells
  70. Stultz CM, White JV, Smith TF. Structural Analysis Based on State Space Modeling. Protein Science. 1993; 2:305-314.
  71. Jacques HPJ, Morris C., Cho E., Stultz C., Yue J. , Laurencin C. Bioerodible Polymers: Novel Approaches for use in Bone. Polymer Preprints. 1990; 31:247.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.