Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Sabina Berretta, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH120991 (BERRETTA, SABINA) May 20, 2020 - Feb 28, 2025
    Dysregulation of Appetitive & Aversive Amygdala Circuits in Bipolar Disorder
    Role: Principal Investigator
  2. R21MH117609 (KLENGEL, TORSTEN) Dec 1, 2018 - Nov 30, 2021
    A role for circular RNAs in schizophrenia
    Role: Principal Investigator
  3. R01MH105608 (BERRETTA, SABINA) Sep 1, 2015 - Dec 31, 2019
    Thalamic axonal pathways and extracellular matrix abnormalities in schizophrenia
    Role: Principal Investigator
  4. R01MH104488 (BERRETTA, SABINA) Mar 1, 2015 - Feb 28, 2021
    Choroid plexus and mis_regulation of brain OTX2 in schizophrenia
    Role: Principal Investigator
  5. R01MH091348 (BERRETTA, SABINA) May 26, 2011 - Feb 28, 2017
    Extracellular anomalies in Schizophrenia: from molecules to symptoms
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Folorunso OO, Harvey TL, Brown SE, Chelini G, Berretta S, Balu DT. The D-serine biosynthetic enzyme serine racemase is expressed by reactive astrocytes in the amygdala of human and a mouse model of Alzheimer's disease. Neurosci Lett. 2023 01 01; 792:136958. PMID: 36356820; PMCID: PMC9730428.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Weiner DJ, Ling E, Erdin S, Tai DJC, Yadav R, Grove J, Fu JM, Nadig A, Carey CE, Baya N, Bybjerg-Grauholm J, Berretta S, Macosko EZ, Sebat J, O'Connor LJ, Hougaard DM, Børglum AD, Talkowski ME, McCarroll SA, Robinson EB. Statistical and functional convergence of common and rare genetic influences on autism at chromosome 16p. Nat Genet. 2022 11; 54(11):1630-1639. PMID: 36280734; PMCID: PMC9649437.
    Citations: 1     Fields:    Translation:HumansCells
  3. Pantazopoulos H, Berretta S. Editorial: Brain extracellular matrix: Involvement in adult neural functions and disease volume II. Front Integr Neurosci. 2022; 16:1009456. PMID: 36046614; PMCID: PMC9421608.
  4. Pantazopoulos H, Hossain NM, Chelini G, Durning P, Barbas H, Zikopoulos B, Berretta S. Chondroitin Sulphate Proteoglycan Axonal Coats in the Human Mediodorsal Thalamic Nucleus. Front Integr Neurosci. 2022; 16:934764. PMID: 35875507; PMCID: PMC9298528.
  5. Ressler KJ, Berretta S, Bolshakov VY, Rosso IM, Meloni EG, Rauch SL, Carlezon WA. Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits. Nat Rev Neurol. 2022 05; 18(5):273-288. PMID: 35352034; PMCID: PMC9682920.
    Citations: 2     Fields:    Translation:HumansAnimals
  6. Hafez AK, Zimmerman AJ, Papageorgiou G, Chandrasekaran J, Amoah SK, Lin R, Lozano E, Pierotti C, Dell'Orco M, Hartley BJ, Alural B, Lalonde J, Esposito JM, Berretta S, Squassina A, Chillotti C, Voloudakis G, Shao Z, Fullard JF, Brennand KJ, Turecki G, Roussos P, Perlis RH, Haggarty SJ, Perrone-Bizzozero N, Brigman JL, Mellios N. A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning. Cell Rep. 2022 01 18; 38(3):110282. PMID: 35045295; PMCID: PMC8809079.
    Citations:    Fields:    Translation:HumansAnimals
  7. Krienen FM, Goldman M, Zhang Q, Del Rosario RCH, Florio M, Machold R, Saunders A, Levandowski K, Zaniewski H, Schuman B, Wu C, Lutservitz A, Mullally CD, Reed N, Bien E, Bortolin L, Fernandez-Otero M, Lin JD, Wysoker A, Nemesh J, Kulp D, Burns M, Tkachev V, Smith R, Walsh CA, Dimidschstein J, Rudy B, Kean LS, Berretta S, Fishell G, Feng G, McCarroll SA. Author Correction: Innovations present in the primate interneuron repertoire. Nature. 2020 Dec; 588(7837):E17. PMID: 33230336.
    Citations:    Fields:    
  8. Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, Miller BL, Berretta S, Hedreen JC, Grinberg LT, Seeley WW, Hyman BT, Steen H, Steen JA. Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. Cell. 2020 12 10; 183(6):1699-1713.e13. PMID: 33188775.
    Citations: 84     Fields:    Translation:HumansCells
  9. Pantazopoulos H, Katsel P, Haroutunian V, Chelini G, Klengel T, Berretta S. Molecular signature of extracellular matrix pathology in schizophrenia. Eur J Neurosci. 2021 06; 53(12):3960-3987. PMID: 33070392.
    Citations: 13     Fields:    Translation:HumansCells
  10. Hart KL, Pellegrini AM, Forester BP, Berretta S, Murphy SN, Perlis RH, McCoy TH. Distribution of agitation and related symptoms among hospitalized patients using a scalable natural language processing method. Gen Hosp Psychiatry. 2021 Jan-Feb; 68:46-51. PMID: 33310013.
    Citations: 2     Fields:    Translation:Humans
  11. Krienen FM, Goldman M, Zhang Q, C H Del Rosario R, Florio M, Machold R, Saunders A, Levandowski K, Zaniewski H, Schuman B, Wu C, Lutservitz A, Mullally CD, Reed N, Bien E, Bortolin L, Fernandez-Otero M, Lin JD, Wysoker A, Nemesh J, Kulp D, Burns M, Tkachev V, Smith R, Walsh CA, Dimidschstein J, Rudy B, S Kean L, Berretta S, Fishell G, Feng G, McCarroll SA. Innovations present in the primate interneuron repertoire. Nature. 2020 10; 586(7828):262-269. PMID: 32999462; PMCID: PMC7957574.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  12. Pantazopoulos H, Gisabella B, Rexrode L, Benefield D, Yildiz E, Seltzer P, Valeri J, Chelini G, Reich A, Ardelt M, Berretta S. Circadian Rhythms of Perineuronal Net Composition. eNeuro. 2020 Jul/Aug; 7(4). PMID: 32719104; PMCID: PMC7405073.
    Citations: 15     Fields:    Translation:AnimalsCells
  13. Sillivan SE, Jamieson S, de Nijs L, Jones M, Snijders C, Klengel T, Joseph NF, Krauskopf J, Kleinjans J, Vinkers CH, Boks MPM, Geuze E, Vermetten E, Berretta S, Ressler KJ, Rutten BPF, Rumbaugh G, Miller CA. Correction: MicroRNA regulation of persistent stress-enhanced memory. Mol Psychiatry. 2020 May; 25(5):1154. PMID: 31253953.
    Citations: 3     Fields:    
  14. McCoy TH, Han L, Pellegrini AM, Tanzi RE, Berretta S, Perlis RH. Stratifying risk for dementia onset using large-scale electronic health record data: A retrospective cohort study. Alzheimers Dement. 2020 03; 16(3):531-540. PMID: 31859230.
    Citations: 10     Fields:    Translation:Humans
  15. Tsilioni I, Patel AB, Pantazopoulos H, Berretta S, Conti P, Leeman SE, Theoharides TC. IL-37 is increased in brains of children with autism spectrum disorder and inhibits human microglia stimulated by neurotensin. Proc Natl Acad Sci U S A. 2019 10 22; 116(43):21659-21665. PMID: 31591201; PMCID: PMC6815178.
    Citations: 14     Fields:    Translation:HumansCells
  16. Pizzagalli DA, Berretta S, Wooten D, Goer F, Pilobello KT, Kumar P, Murray L, Beltzer M, Boyer-Boiteau A, Alpert N, El Fakhri G, Mechawar N, Vitaliano G, Turecki G, Normandin M. Assessment of Striatal Dopamine Transporter Binding in Individuals With Major Depressive Disorder: In Vivo Positron Emission Tomography and Postmortem Evidence. JAMA Psychiatry. 2019 08 01; 76(8):854-861. PMID: 31042280; PMCID: PMC6495358.
    Citations: 12     Fields:    Translation:Humans
  17. Balu DT, Pantazopoulos H, Huang CCY, Muszynski K, Harvey TL, Uno Y, Rorabaugh JM, Galloway CR, Botz-Zapp C, Berretta S, Weinshenker D, Coyle JT. Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease. Neurobiol Dis. 2019 10; 130:104511. PMID: 31212068; PMCID: PMC6689433.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  18. Sillivan SE, Jamieson S, de Nijs L, Jones M, Snijders C, Klengel T, Joseph NF, Krauskopf J, Kleinjans J, Vinkers CH, Boks MPM, Geuze E, Vermetten E, Berretta S, Ressler KJ, Rutten BPF, Rumbaugh G, Miller CA. MicroRNA regulation of persistent stress-enhanced memory. Mol Psychiatry. 2020 05; 25(5):965-976. PMID: 31142820.
    Citations: 12     Fields:    Translation:HumansAnimals
  19. Chelini G, Pantazopoulos H, Durning P, Berretta S. The tetrapartite synapse: a key concept in the pathophysiology of schizophrenia. Eur Psychiatry. 2018 04; 50:60-69. PMID: 29503098; PMCID: PMC5963512.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  20. Sullivan K, Pantazopoulos H, Liebson E, Woo TW, Baldessarini RJ, Hedreen J, Berretta S. What can we learn about brain donors? Use of clinical information in human postmortem brain research. Handb Clin Neurol. 2018; 150:181-196. PMID: 29496141.
    Citations: 1     Fields:    Translation:Humans
  21. Sorg BA, Berretta S, Blacktop JM, Fawcett JW, Kitagawa H, Kwok JC, Miquel M. Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity. J Neurosci. 2016 11 09; 36(45):11459-11468. PMID: 27911749; PMCID: PMC5125213.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  22. Sonntag KC, Tejada G, Subburaju S, Berretta S, Benes FM, Woo TU. Limited predictability of postmortem human brain tissue quality by RNA integrity numbers. J Neurochem. 2016 07; 138(1):53-9. PMID: 27062510; PMCID: PMC4915987.
    Citations: 17     Fields:    Translation:HumansCells
  23. Pantazopoulos H, Wiseman JT, Markota M, Ehrenfeld L, Berretta S. Decreased Numbers of Somatostatin-Expressing Neurons in the Amygdala of Subjects With Bipolar Disorder or Schizophrenia: Relationship to Circadian Rhythms. Biol Psychiatry. 2017 03 15; 81(6):536-547. PMID: 27259817; PMCID: PMC5065936.
    Citations: 23     Fields:    Translation:HumansCells
  24. Dauth S, Grevesse T, Pantazopoulos H, Campbell PH, Maoz BM, Berretta S, Parker KK. Extracellular matrix protein expression is brain region dependent. J Comp Neurol. 2016 May 01; 524(7):1309-36. PMID: 26780384.
    Citations: 49     Fields:    Translation:AnimalsCells
  25. Pantazopoulos H, Berretta S. In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders. Neural Plast. 2016; 2016:9847696. PMID: 26839720; PMCID: PMC4709762.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  26. Pantazopoulos H, Markota M, Jaquet F, Ghosh D, Wallin A, Santos A, Caterson B, Berretta S. Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala. Transl Psychiatry. 2015 Jan 20; 5:e496. PMID: 25603412.
    Citations: 54     Fields:    Translation:HumansCells
  27. Berretta S, Pantazopoulos H, Markota M, Brown C, Batzianouli ET. Losing the sugar coating: potential impact of perineuronal net abnormalities on interneurons in schizophrenia. Schizophr Res. 2015 Sep; 167(1-3):18-27. PMID: 25601362; PMCID: PMC4504843.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  28. Berretta S, Heckers S, Benes FM. Searching human brain for mechanisms of psychiatric disorders. Implications for studies on schizophrenia. Schizophr Res. 2015 Sep; 167(1-3):91-7. PMID: 25458567; PMCID: PMC4427537.
    Citations: 5     Fields:    Translation:Humans
  29. Markota M, Sin J, Pantazopoulos H, Jonilionis R, Berretta S. Reduced dopamine transporter expression in the amygdala of subjects diagnosed with schizophrenia. Schizophr Bull. 2014 Sep; 40(5):984-91. PMID: 24936023.
    Citations: 16     Fields:    Translation:Humans
  30. Pantazopoulos H, Boyer-Boiteau A, Holbrook EH, Jang W, Hahn CG, Arnold SE, Berretta S. Proteoglycan abnormalities in olfactory epithelium tissue from subjects diagnosed with schizophrenia. Schizophr Res. 2013 Nov; 150(2-3):366-72. PMID: 24035561.
    Citations: 22     Fields:    Translation:Humans
  31. Mauney SA, Athanas KM, Pantazopoulos H, Shaskan N, Passeri E, Berretta S, Woo TU. Developmental pattern of perineuronal nets in the human prefrontal cortex and their deficit in schizophrenia. Biol Psychiatry. 2013 Sep 15; 74(6):427-35. PMID: 23790226.
    Citations: 122     Fields:    Translation:HumansCells
  32. Wang AY, Lohmann KM, Yang CK, Zimmerman EI, Pantazopoulos H, Herring N, Berretta S, Heckers S, Konradi C. Bipolar disorder type 1 and schizophrenia are accompanied by decreased density of parvalbumin- and somatostatin-positive interneurons in the parahippocampal region. Acta Neuropathol. 2011 Nov; 122(5):615-26. PMID: 21968533.
    Citations: 50     Fields:    Translation:HumansCells
  33. Berretta S. Extracellular matrix abnormalities in schizophrenia. Neuropharmacology. 2012 Mar; 62(3):1584-97. PMID: 21856318; PMCID: PMC3234338.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  34. Konradi C, Yang CK, Zimmerman EI, Lohmann KM, Gresch P, Pantazopoulos H, Berretta S, Heckers S. Hippocampal interneurons are abnormal in schizophrenia. Schizophr Res. 2011 Sep; 131(1-3):165-73. PMID: 21745723.
    Citations: 128     Fields:    Translation:HumansCells
  35. Konradi C, Zimmerman EI, Yang CK, Lohmann KM, Gresch P, Pantazopoulos H, Berretta S, Heckers S. Hippocampal interneurons in bipolar disorder. Arch Gen Psychiatry. 2011 Apr; 68(4):340-50. PMID: 21135314; PMCID: PMC3197787.
    Citations: 46     Fields:    Translation:HumansCells
  36. Pantazopoulos H, Woo TU, Lim MP, Lange N, Berretta S. Extracellular matrix-glial abnormalities in the amygdala and entorhinal cortex of subjects diagnosed with schizophrenia. Arch Gen Psychiatry. 2010 Feb; 67(2):155-66. PMID: 20124115; PMCID: PMC4208310.
    Citations: 130     Fields:    Translation:HumansCells
  37. Berretta S, Gisabella B, Benes FM. A rodent model of schizophrenia derived from postmortem studies. Behav Brain Res. 2009 Dec 07; 204(2):363-8. PMID: 19539659.
    Citations: 4     Fields:    Translation:AnimalsCells
  38. Pantazopoulos H, Murray EA, Berretta S. Total number, distribution, and phenotype of cells expressing chondroitin sulfate proteoglycans in the normal human amygdala. Brain Res. 2008 May 01; 1207:84-95. PMID: 18374308.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  39. Sheth A, Berretta S, Lange N, Eichenbaum H. The amygdala modulates neuronal activation in the hippocampus in response to spatial novelty. Hippocampus. 2008; 18(2):169-81. PMID: 17960646.
    Citations: 14     Fields:    Translation:AnimalsCells
  40. Berretta S, Pantazopoulos H, Lange N. Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia. Biol Psychiatry. 2007 Oct 15; 62(8):884-93. PMID: 17698040.
    Citations: 47     Fields:    Translation:HumansCells
  41. Pantazopoulos H, Lange N, Baldessarini RJ, Berretta S. Parvalbumin neurons in the entorhinal cortex of subjects diagnosed with bipolar disorder or schizophrenia. Biol Psychiatry. 2007 Mar 01; 61(5):640-52. PMID: 16950219; PMCID: PMC1964505.
    Citations: 34     Fields:    Translation:HumansCells
  42. Pantazopoulos H, Lange N, Hassinger L, Berretta S. Subpopulations of neurons expressing parvalbumin in the human amygdala. J Comp Neurol. 2006 Jun 10; 496(5):706-22. PMID: 16615121.
    Citations: 25     Fields:    Translation:HumansCells
  43. Berretta S, Benes FM. A rat model for neural circuitry abnormalities in schizophrenia. Nat Protoc. 2006; 1(2):833-9. PMID: 17406315.
    Citations: 4     Fields:    Translation:AnimalsCells
  44. Berretta S. Cortico-amygdala circuits: role in the conditioned stress response. Stress. 2005 Dec; 8(4):221-32. PMID: 16423711.
    Citations: 18     Fields:    Translation:HumansAnimals
  45. Berretta S, Pantazopoulos H, Caldera M, Pantazopoulos P, Paré D. Infralimbic cortex activation increases c-Fos expression in intercalated neurons of the amygdala. Neuroscience. 2005; 132(4):943-53. PMID: 15857700.
    Citations: 106     Fields:    Translation:AnimalsCells
  46. Benes FM, Burke RE, Walsh J, Berretta S, Matzilevich D, Minns M, Konradi C. Acute amygdalar activation induces an upregulation of multiple monoamine G protein coupled pathways in rat hippocampus. Mol Psychiatry. 2004 Oct; 9(10):932-45, 895. PMID: 15170462.
    Citations: 8     Fields:    Translation:AnimalsCells
  47. Berretta S, Lange N, Bhattacharyya S, Sebro R, Garces J, Benes FM. Long-term effects of amygdala GABA receptor blockade on specific subpopulations of hippocampal interneurons. Hippocampus. 2004; 14(7):876-94. PMID: 15382257.
    Citations: 28     Fields:    Translation:AnimalsCells
  48. Benes FM, Walsh J, Bhattacharyya S, Sheth A, Berretta S. DNA fragmentation decreased in schizophrenia but not bipolar disorder. Arch Gen Psychiatry. 2003 Apr; 60(4):359-64. PMID: 12695312.
    Citations: 22     Fields:    Translation:Humans
  49. Benes FM, Berretta S. GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder. Neuropsychopharmacology. 2001 Jul; 25(1):1-27. PMID: 11377916.
    Citations: 407     Fields:    Translation:HumansAnimalsCells
  50. Berretta S, Munno DW, Benes FM. Amygdalar activation alters the hippocampal GABA system: "partial" modelling for postmortem changes in schizophrenia. J Comp Neurol. 2001 Mar 05; 431(2):129-38. PMID: 11169995.
    Citations: 23     Fields:    Translation:AnimalsCells
  51. Benes FM, Berretta S. Amygdalo-entorhinal inputs to the hippocampal formation in relation to schizophrenia. Ann N Y Acad Sci. 2000 Jun; 911:293-304. PMID: 10911881.
    Citations: 21     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.