Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Shaun Purcell, Ph.D.

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Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AG070867 (REDLINE, SUSAN S.) May 1, 2021 - Feb 28, 2025
    NIH
    Longitudinal Relationships Among Sleep, Cognition and Alzheimer's Disease Biomarkers: Discerning Causal Associations, Mediators and Susceptibility
    Role: Co-Principal Investigator
  2. R21MD012738 (PURCELL, SHAUN M) Sep 17, 2019 - Jun 30, 2021
    NIH
    Enhanced Measurement and Modeling of Sleep Electrophysiology to Better Understand Sleep Disparities
    Role: Principal Investigator
  3. R21HL145492 (PURCELL, SHAUN M) Apr 1, 2019 - Mar 31, 2021
    NIH
    Sleep Physiology Dynamics: Quantification, Characterization and Genetic Dissection
    Role: Principal Investigator
  4. R01HL146339 (PURCELL, SHAUN M) Jan 22, 2019 - Dec 31, 2021
    NIH
    Leveraging National Sleep Research Resource Data for Personalized Sleep Profiling
    Role: Principal Investigator
  5. R03MH108908 (PURCELL, SHAUN M) Aug 15, 2016 - Jun 30, 2018
    NIH
    Genome-wide association study of sleep spindles and related polysomnography measures
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Stokes PA, Rath P, Possidente T, He M, Purcell S, Manoach DS, Stickgold R, Prerau MJ. Transient oscillation dynamics during sleep provide a robust basis for electroencephalographic phenotyping and biomarker identification. Sleep. 2023 Jan 11; 46(1). PMID: 36107467; PMCID: PMC9832519.
    Citations:    Fields:    Translation:Humans
  2. Liang J, Wang H, Cade BE, Kurniansyah N, He KY, Lee J, Sands SA, A Brody J, Chen H, Gottlieb DJ, Evans DS, Guo X, Gharib SA, Hale L, Hillman DR, Lutsey PL, Mukherjee S, Ochs-Balcom HM, Palmer LJ, Purcell S, Saxena R, Patel SR, Stone KL, Tranah GJ, Boerwinkle E, Lin X, Liu Y, Psaty BM, Vasan RS, Manichaikul A, Rich SS, Rotter JI, Sofer T, Redline S, Zhu X. Targeted Genome Sequencing Identifies Multiple Rare Variants in Caveolin-1 Associated with Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2022 11 15; 206(10):1271-1280. PMID: 35822943; PMCID: PMC9746833.
    Citations:    Fields:    
  3. Kozhemiako N, Mylonas D, Pan JQ, Prerau MJ, Redline S, Purcell SM. Sources of Variation in the Spectral Slope of the Sleep EEG. eNeuro. 2022 Sep-Oct; 9(5). PMID: 36123117; PMCID: PMC9512622.
    Citations:    Fields:    Translation:Humans
  4. Green SF, Frame T, Banerjee LV, Gimson A, Blackman J, Morrison H, Lloyd K, Rudd S, Frederick Fotherby WG, Bartsch U, Purcell S, Jones M, Coulthard L. A systematic review of the validity of non-invasive sleep-measuring devices in mid-to-late life adults: Future utility for Alzheimer's disease research. Sleep Med Rev. 2022 10; 65:101665. PMID: 36208588.
    Citations:    Fields:    Translation:Humans
  5. Xin Q, Yuan RK, Zitting KM, Wang W, Purcell SM, Vujovic N, Ronda JM, Quan SF, Williams JS, Buxton OM, Duffy JF, Czeisler CA. Impact of chronic sleep restriction on sleep continuity, sleep structure, and neurobehavioral performance. Sleep. 2022 07 11; 45(7). PMID: 35218665; PMCID: PMC9272266.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  6. Mazzotti DR, Haendel MA, McMurry JA, Smith CJ, Buysse DJ, Roenneberg T, Penzel T, Purcell S, Redline S, Zhang Y, Merikangas KR, Menetski JP, Mullington J, Boudreau E. Sleep and circadian informatics data harmonization: a workshop report from the Sleep Research Society and Sleep Research Network. Sleep. 2022 06 13; 45(6). PMID: 35030631; PMCID: PMC9189941.
    Citations:    Fields:    Translation:Humans
  7. Kozhemiako N, Wang J, Jiang C, Wang LA, Gai G, Zou K, Wang Z, Yu X, Zhou L, Li S, Guo Z, Law R, Coleman J, Mylonas D, Shen L, Wang G, Tan S, Qin S, Huang H, Murphy M, Stickgold R, Manoach D, Zhou Z, Zhu W, Hal MH, Purcell SM, Pan JQ. Non-rapid eye movement sleep and wake neurophysiology in schizophrenia. Elife. 2022 05 17; 11. PMID: 35578829; PMCID: PMC9113745.
    Citations:    Fields:    Translation:Humans
  8. Wang H, Kurniansyah N, Cade BE, Goodman MO, Chen H, Gottlieb DJ, Gharib SA, Purcell SM, Lin X, Saxena R, Zhu X, Durda P, Tracy R, Liu Y, Taylor KD, Johnson WC, Gabriel S, Smith JD, Aguet F, Ardlie K, Blackwell T, Reiner AP, Rotter JI, Rich SS, Redline S, Sofer T. Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study. Sci Rep. 2022 01 27; 12(1):1472. PMID: 35087136; PMCID: PMC8795126.
    Citations:    Fields:    Translation:HumansCells
  9. Jia X, Goes FS, Locke AE, Palmer D, Wang W, Cohen-Woods S, Genovese G, Jackson AU, Jiang C, Kvale M, Mullins N, Nguyen H, Pirooznia M, Rivera M, Ruderfer DM, Shen L, Thai K, Zawistowski M, Zhuang Y, Abecasis G, Akil H, Bergen S, Burmeister M, Chapman S, DelaBastide M, Juréus A, Kang HM, Kwok PY, Li JZ, Levy SE, Monson ET, Moran J, Sobell J, Watson S, Willour V, Zöllner S, Adolfsson R, Blackwood D, Boehnke M, Breen G, Corvin A, Craddock N, DiFlorio A, Hultman CM, Landen M, Lewis C, McCarroll SA, Richard McCombie W, McGuffin P, McIntosh A, McQuillin A, Morris D, Myers RM, O'Donovan M, Ophoff R, Boks M, Kahn R, Ouwehand W, Owen M, Pato C, Pato M, Posthuma D, Potash JB, Reif A, Sklar P, Smoller J, Sullivan PF, Vincent J, Walters J, Neale B, Purcell S, Risch N, Schaefer C, Stahl EA, Zandi PP, Scott LJ. Correction: Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder. Mol Psychiatry. 2021 Sep; 26(9):5251. PMID: 33674754; PMCID: PMC9119210.
    Citations:    Fields:    
  10. Cade BE, Lee J, Sofer T, Wang H, Zhang M, Chen H, Gharib SA, Gottlieb DJ, Guo X, Lane JM, Liang J, Lin X, Mei H, Patel SR, Purcell SM, Saxena R, Shah NA, Evans DS, Hanis CL, Hillman DR, Mukherjee S, Palmer LJ, Stone KL, Tranah GJ, Abecasis GR, Boerwinkle EA, Correa A, Cupples LA, Kaplan RC, Nickerson DA, North KE, Psaty BM, Rotter JI, Rich SS, Tracy RP, Vasan RS, Wilson JG, Zhu X, Redline S. Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program. Genome Med. 2021 08 26; 13(1):136. PMID: 34446064; PMCID: PMC8394596.
    Citations:    Fields:    Translation:HumansCells
  11. Redline S, Purcell SM. Sleep and Big Data: harnessing data, technology, and analytics for monitoring sleep and improving diagnostics, prediction, and interventions-an era for Sleep-Omics? Sleep. 2021 06 11; 44(6). PMID: 33893509; PMCID: PMC8521745.
    Citations: 4     Fields:    
  12. Jia X, Goes FS, Locke AE, Palmer D, Wang W, Cohen-Woods S, Genovese G, Jackson AU, Jiang C, Kvale M, Mullins N, Nguyen H, Pirooznia M, Rivera M, Ruderfer DM, Shen L, Thai K, Zawistowski M, Zhuang Y, Abecasis G, Akil H, Bergen S, Burmeister M, Chapman S, DelaBastide M, Juréus A, Kang HM, Kwok PY, Li JZ, Levy SE, Monson ET, Moran J, Sobell J, Watson S, Willour V, Zöllner S, Adolfsson R, Blackwood D, Boehnke M, Breen G, Corvin A, Craddock N, DiFlorio A, Hultman CM, Landen M, Lewis C, McCarroll SA, Richard McCombie W, McGuffin P, McIntosh A, McQuillin A, Morris D, Myers RM, O'Donovan M, Ophoff R, Boks M, Kahn R, Ouwehand W, Owen M, Pato C, Pato M, Posthuma D, Potash JB, Reif A, Sklar P, Smoller J, Sullivan PF, Vincent J, Walters J, Neale B, Purcell S, Risch N, Schaefer C, Stahl EA, Zandi PP, Scott LJ. Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder. Mol Psychiatry. 2021 09; 26(9):5239-5250. PMID: 33483695; PMCID: PMC8295400.
    Citations: 4     Fields:    Translation:Humans
  13. Djonlagic I, Mariani S, Fitzpatrick AL, Van Der Klei VMGTH, Johnson DA, Wood AC, Seeman T, Nguyen HT, Prerau MJ, Luchsinger JA, Dzierzewski JM, Rapp SR, Tranah GJ, Yaffe K, Burdick KE, Stone KL, Redline S, Purcell SM. Publisher Correction: Macro and micro sleep architecture and cognitive performance in older adults. Nat Hum Behav. 2021 Jan; 5(1):172-174. PMID: 33328625.
    Citations: 1     Fields:    
  14. Djonlagic I, Mariani S, Fitzpatrick AL, Van Der Klei VMGTH, Johnson DA, Wood AC, Seeman T, Nguyen HT, Prerau MJ, Luchsinger JA, Dzierzewski JM, Rapp SR, Tranah GJ, Yaffe K, Burdick KE, Stone KL, Redline S, Purcell SM. Macro and micro sleep architecture and cognitive performance in older adults. Nat Hum Behav. 2021 01; 5(1):123-145. PMID: 33199858.
    Citations: 17     Fields:    Translation:Humans
  15. Nguyen TH, Dobbyn A, Brown RC, Riley BP, Buxbaum JD, Pinto D, Purcell SM, Sullivan PF, He X, Stahl EA. mTADA is a framework for identifying risk genes from de novo mutations in multiple traits. Nat Commun. 2020 06 10; 11(1):2929. PMID: 32522981.
    Citations: 5     Fields:    Translation:Humans
  16. Won CHJ, Reid M, Sofer T, Azarbarzin A, Purcell S, White D, Wellman A, Sands S, Redline S. Sex differences in obstructive sleep apnea phenotypes, the multi-ethnic study of atherosclerosis. Sleep. 2020 05 12; 43(5). PMID: 31687772.
    Citations: 30     Fields:    Translation:Humans
  17. Sham PC, Purcell SM, Cherny SS, Neale MC, Neale BM. Statistical Power and the Classical Twin Design. Twin Res Hum Genet. 2020 04; 23(2):87-89. PMID: 32638684.
    Citations: 1     Fields:    Translation:Humans
  18. Smagula SF, Sofer T, Guo N, Prerau M, Purcell S, Mariani S, Yaffe K, Redline S, Stone KL. Spectral sleep electroencephalographic correlates of sleep efficiency, and discrepancies between actigraphy and self-reported measures, in older men. J Sleep Res. 2021 04; 30(2):e13033. PMID: 32198950; PMCID: PMC7607534.
    Citations: 2