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Tatsuya Kobayashi, Ph.D., M.D.


Skeletal development, mouse genetics, chondrocytes, regulatory mechanisms for gene expression in the skeletal system, microRNAs

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. PR181712 (Kobayash, Tatsuya) Sep 30, 2019 - Mar 30, 2021
    Targeting Piezo Ion Channels for Mitigation of Osteoarthritis Pain and Disease Progression
    Role: Principal Investigator
  2. R61 AR076775 (KOBAYASHI, TATSUYA) Sep 30, 2019 - Sep 29, 2020
    Manipulation of Sox9(+) bone marrow cells towards cell-based gene therapy
    Role: Principal Investigator
  3. R61AR076775 (KOBAYASHI, TATSUYA) Sep 17, 2019 - Sep 16, 2020
    Manipulation of Sox9-positive osteochondroprogenitor cells towards cell-based gene therapy for genetic bone diseases.
    Role: Principal Investigator
  4. 3R01AR056645-08S1 (KOBAYASHI, TATSUYA) Jul 1, 2018 - Feb 28, 2020
    Role of miR-17-92 miRNAs in skeletal development and bone homeostasis
    Role: Principal Investigator
  5. SG-0090-13 (Tatsuya Kobayashi) Jul 1, 2013 - Sep 30, 2015
    Characterization and manipulation of articular cartilage chondrocytes as stem/progenitor cells
    Role: PI

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shvedova M, Kobayashi T. MicroRNAs in cartilage development and dysplasia. Bone. 2020 Nov; 140:115564. PMID: 32745689.
  2. Nishimori S, Lai F, Shiraishi M, Kobayashi T, Kozhemyakina E, Yao TP, Lassar AB, Kronenberg HM. PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy. JCI Insight. 2019 03 07; 4(5). PMID: 30843886.
  3. Grigelioniene G, Suzuki HI, Taylan F, Mirzamohammadi F, Borochowitz ZU, Ayturk UM, Tzur S, Horemuzova E, Lindstrand A, Weis MA, Grigelionis G, Hammarsjö A, Marsk E, Nordgren A, Nordenskjöld M, Eyre DR, Warman ML, Nishimura G, Sharp PA, Kobayashi T. Gain-of-function mutation of microRNA-140 in human skeletal dysplasia. Nat Med. 2019 04; 25(4):583-590. PMID: 30804514.
  4. Ambrozkiewicz MC, Schwark M, Kishimoto-Suga M, Borisova E, Hori K, Salazar-Lázaro A, Rusanova A, Altas B, Piepkorn L, Bessa P, Schaub T, Zhang X, Rabe T, Ripamonti S, Rosário M, Akiyama H, Jahn O, Kobayashi T, Hoshino M, Tarabykin V, Kawabe H. Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140. Neuron. 2018 12 05; 100(5):1097-1115.e15. PMID: 30392800.
    Citations:    Fields:    
  5. Papaioannou G, Kozlova A, Kobayashi T. Curr Mol Bio Rep. miRNA Regulation of Chondrogenesis. 2018; 4(4):208-217.
  6. Kobayashi T, Kozlova A. Lin28a overexpression reveals the role of Erk signaling in articular cartilage development. Development. 2018 08 02; 145(15). PMID: 30042178.
    Citations:    Fields:    Translation:AnimalsCells
  7. Suzuki HI, Spengler RM, Grigelioniene G, Kobayashi T, Sharp PA. Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics. Nat Genet. 2018 05; 50(5):657-661. PMID: 29662165.
    Citations: 2     Fields:    
  8. Mirzamohammadi F, Kozlova A, Papaioannou G, Paltrinieri E, Ayturk UM, Kobayashi T. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. Nat Commun. 2018 04 10; 9(1):1352. PMID: 29636449.
    Citations:    Fields:    Translation:HumansAnimalsCells
  9. Papaioannou G, Mirzamohammadi F, Kobayashi T. Ras signaling regulates osteoprogenitor cell proliferation and bone formation. Cell Death Dis. 2016 10 13; 7(10):e2405. PMID: 27735946.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-ß signalling. Nat Commun. 2016 06 22; 7:12047. PMID: 27329220.
    Citations: 7     Fields:    Translation:AnimalsCells
  11. Kong L, Zhao YP, Tian QY, Feng JQ, Kobayashi T, Merregaert J, Liu CJ. Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor. FASEB J. 2016 08; 30(8):2741-54. PMID: 27075243.
    Citations:    Fields:    Translation:Animals
  12. Fan Y, Bi R, Densmore MJ, Sato T, Kobayashi T, Yuan Q, Zhou X, Erben RG, Lanske B. Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. FASEB J. 2016 Jan; 30(1):428-40. PMID: 26428657.
    Citations: 15     Fields:    Translation:Animals
  13. Nakamura Y, Kikugawa S, Seki S, Takahata M, Iwasaki N, Terai H, Matsubara M, Fujioka F, Inagaki H, Kobayashi T, Kimura T, Kurahashi H, Kato H. PCSK5 mutation in a patient with the VACTERL association. BMC Res Notes. 2015 Jun 09; 8:228. PMID: 26055999.
    Citations: 3     Fields:    Translation:Humans
  14. Hirai T, Kobayashi T, Nishimori S, Karaplis AC, Goltzman D, Kronenberg HM. Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis. Endocrinology. 2015 Aug; 156(8):2774-80. PMID: 26052897.
    Citations: 4     Fields:    Translation:AnimalsCells
  15. Papaioannou G, Mirzamohammadi F, Lisse TS, Nishimori S, Wein MN, Kobayashi T. MicroRNA-140 Provides Robustness to the Regulation of Hypertrophic Chondrocyte Differentiation by the PTHrP-HDAC4 Pathway. J Bone Miner Res. 2015 Jun; 30(6):1044-52. PMID: 25529628.
    Citations: 7     Fields:    Translation:AnimalsCells
  16. Kobayashi T, Papaioannou G, Mirzamohammadi F, Kozhemyakina E, Zhang M, Blelloch R, Chong MW. Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage. Osteoarthritis Cartilage. 2015 Jul; 23(7):1214-20. PMID: 25707934.
    Citations: 10     Fields:    Translation:AnimalsCells
  17. Mirzamohammadi F, Papaioannou G, Kobayashi T. MicroRNAs in cartilage development, homeostasis, and disease. Curr Osteoporos Rep. 2014 Dec; 12(4):410-9. PMID: 25091054.
    Citations: 17     Fields:    Translation:HumansCells
  18. Papaioannou G, Mirzamohammadi F, Kobayashi T. MicroRNAs involved in bone formation. Cell Mol Life Sci. 2014 Dec; 71(24):4747-61. PMID: 25108446.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  19. Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, Offermanns S, Weinstein LS, Kronenberg HM. G-protein stimulatory subunit alpha and Gq/11a G-proteins are both required to maintain quiescent stem-like chondrocytes. Nat Commun. 2014 Apr 30; 5:3673. PMID: 24781502.
    Citations: 13     Fields:    Translation:AnimalsCells
  20. Kuchimaru T, Hoshino T, Aikawa T, Yasuda H, Kobayashi T, Kadonosono T, Kizaka-Kondoh S. Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia. Cancer Sci. 2014 May; 105(5):553-9. PMID: 24597654.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. Kobayashi T, Kronenberg HM. Overview of skeletal development. Methods Mol Biol. 2014; 1130:3-12. PMID: 24482161.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  22. Papaioannou G, Inloes JB, Nakamura Y, Paltrinieri E, Kobayashi T. let-7 and miR-140 microRNAs coordinately regulate skeletal development. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3291-300. PMID: 23940373.
    Citations: 28     Fields:    Translation:AnimalsCells
  23. Park D, Spencer JA, Koh BI, Kobayashi T, Fujisaki J, Clemens TL, Lin CP, Kronenberg HM, Scadden DT. Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell. 2012 Mar 02; 10(3):259-72. PMID: 22385654.
    Citations: 176     Fields:    Translation:HumansAnimalsCells
  24. Nakamura Y, He X, Kato H, Wakitani S, Kobayashi T, Watanabe S, Iida A, Tahara H, Warman ML, Watanapokasin R, Postlethwait JH. Sox9 is upstream of microRNA-140 in cartilage. Appl Biochem Biotechnol. 2012 Jan; 166(1):64-71. PMID: 22052544.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  25. Nakamura Y, Inloes JB, Katagiri T, Kobayashi T. Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling. Mol Cell Biol. 2011 Jul; 31(14):3019-28. PMID: 21576357.
    Citations: 57     Fields:    Translation:AnimalsCells
  26. Powell WF, Barry KJ, Tulum I, Kobayashi T, Harris SE, Bringhurst FR, Pajevic PD. Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses. J Endocrinol. 2011 Apr; 209(1):21-32. PMID: 21220409.
    Citations: 61     Fields:    Translation:AnimalsCells
  27. Hirai T, Chagin AS, Kobayashi T, Mackem S, Kronenberg HM. Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):191-6. PMID: 21173257.
    Citations: 26     Fields:    Translation:AnimalsCells
  28. Tawfeek H, Bedi B, Li JY, Adams J, Kobayashi T, Weitzmann MN, Kronenberg HM, Pacifici R. Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss. PLoS One. 2010 Aug 20; 5(8):e12290. PMID: 20808842.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  29. Maes C, Kobayashi T, Selig MK, Torrekens S, Roth SI, Mackem S, Carmeliet G, Kronenberg HM. Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell. 2010 Aug 17; 19(2):329-44. PMID: 20708594.
    Citations: 248     Fields:    Translation:AnimalsCells
  30. Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature. 2010 Apr 08; 464(7290):852-7. PMID: 20305640.
    Citations: 313     Fields:    Translation:AnimalsCells
  31. Kamiya N, Kobayashi T, Mochida Y, Yu PB, Yamauchi M, Kronenberg HM, Mishina Y. Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res. 2010 Feb; 25(2):200-10. PMID: 19874086.
    Citations: 64     Fields:    Translation:AnimalsCells
  32. Kobayashi T. [Hormones and osteoporosis update. Mechanisms of anabolic and catabolic effects of PTH on bone]. Clin Calcium. 2009 Jul; 19(7):911-8. PMID: 19567985.
    Citations:    Fields:    Translation:HumansAnimalsCells
  33. Bai XH, Wang DW, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg HM, Yu XP, Liu CJ. ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor. Mol Cell Biol. 2009 Aug; 29(15):4201-19. PMID: 19487464.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  34. Miclea RL, Karperien M, Bosch CA, van der Horst G, van der Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akçakaya P, Löwik CW, Fodde R, Wit JM, Robanus-Maandag EC. Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 2009 Apr 08; 9:26. PMID: 19356224.
    Citations: 20     Fields:    Translation:AnimalsCells
  35. Kamiya N, Ye L, Kobayashi T, Lucas DJ, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y. Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass. J Bone Miner Res. 2008 Dec; 23(12):2007-17. PMID: 18684091.
    Citations: 61     Fields:    Translation:AnimalsCells
  36. Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y. BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov; 135(22):3801-11. PMID: 18927151.
    Citations: 87     Fields:    Translation:AnimalsCells
  37. Nakamura Y, He X, Kobayashi T, Yan YL, Postlethwait JH, Warman ML. Unique roles of microRNA140 and its host gene WWP2 in cartilage biology. J Musculoskelet Neuronal Interact. 2008 Oct-Dec; 8(4):321-2. PMID: 19147957.
    Citations: 5     Fields:    Translation:HumansAnimals
  38. Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008 Mar; 14(3):306-14. PMID: 18297083.
    Citations: 196     Fields:    Translation:AnimalsCells
  39. Kobayashi T, Lu J, Cobb BS, Rodda SJ, McMahon AP, Schipani E, Merkenschlager M, Kronenberg HM. Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1949-54. PMID: 18238902.
    Citations: 135     Fields:    Translation:AnimalsCells
  40. Maes C, Kobayashi T, Kronenberg HM. A novel transgenic mouse model to study the osteoblast lineage in vivo. Ann N Y Acad Sci. 2007 Nov; 1116:149-64. PMID: 18083926.
    Citations: 27     Fields:    Translation:AnimalsCells
  41. Kobayashi T, Lyons KM, McMahon AP, Kronenberg HM. BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18023-7. PMID: 16322106.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  42. Miao D, He B, Jiang Y, Kobayashi T, Sorocéanu MA, Zhao J, Su H, Tong X, Amizuka N, Gupta A, Genant HK, Kronenberg HM, Goltzman D, Karaplis AC. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J Clin Invest. 2005 Sep; 115(9):2402-11. PMID: 16138191.
    Citations: 65     Fields:    Translation:AnimalsCells
  43. Kobayashi T, Kronenberg HM, Foley J. Reduced expression of the PTH/PTHrP receptor during development of the mammary gland influences the function of the nipple during lactation. Dev Dyn. 2005 Jul; 233(3):794-803. PMID: 15880431.
    Citations: 11     Fields:    Translation:Animals
  44. Kobayashi T, Soegiarto DW, Yang Y, Lanske B, Schipani E, McMahon AP, Kronenberg HM. Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest. 2005 Jul; 115(7):1734-42. PMID: 15951842.
    Citations: 68     Fields:    Translation:AnimalsCells
  45. Kobayashi T, Kronenberg H. Minireview: transcriptional regulation in development of bone. Endocrinology. 2005 Mar; 146(3):1012-7. PMID: 15604211.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  46. Sakamoto A, Chen M, Kobayashi T, Kronenberg HM, Weinstein LS. Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation. J Bone Miner Res. 2005 Apr; 20(4):663-71. PMID: 15765186.
    Citations: 34     Fields:    Translation:AnimalsCells
  47. Kanatani M, Sugimoto T, Sowa H, Kobayashi T, Kanzawa M, Chihara K. Thyroid hormone stimulates osteoclast differentiation by a mechanism independent of RANKL-RANK interaction. J Cell Physiol. 2004 Oct; 201(1):17-25. PMID: 15281085.
    Citations: 7     Fields:    Translation:AnimalsCells
  48. Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development. 2004 May; 131(10):2497-508. PMID: 15128677.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  49. Shin HI, Divieti P, Sims NA, Kobayashi T, Miao D, Karaplis AC, Baron R, Bringhurst R, Kronenberg HM. Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro. Endocrinology. 2004 Mar; 145(3):1376-85. PMID: 14617570.
    Citations: 13     Fields:    Translation:AnimalsCells
  50. Inoue T, Okada H, Kobayashi T, Watanabe Y, Kikuta T, Kanno Y, Takigawa M, Suzuki H. TGF-beta1 and HGF coordinately facilitate collagen turnover in subepithelial mesenchyme. Biochem Biophys Res Commun. 2002 Sep 20; 297(2):255-60. PMID: 12237111.
  51. Guha U, Gomes WA, Kobayashi T, Pestell RG, Kessler JA. In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb. Dev Biol. 2002 Sep 01; 249(1):108-20. PMID: 12217322.
    Citations: 33     Fields:    Translation:AnimalsCells
  52. Kobayashi T, Chung UI, Schipani E, Starbuck M, Karsenty G, Katagiri T, Goad DL, Lanske B, Kronenberg HM. PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development. 2002 Jun; 129(12):2977-86. PMID: 12050144.
    Citations: 79     Fields:    Translation:AnimalsCells
  53. Kobayashi T, Sugimoto T, Kanzawa M, Chihara K. Identification of an enhancer sequence in 5'-flanking region of 1A exon of mouse liver/bone/kidney-type alkaline phosphatase gene. Biochem Mol Biol Int. 1998 Apr; 44(4):683-91. PMID: 9584982.
    Citations: 1     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.