Profiles Header - Harvard Catalyst Profiles Header – Harvard Catalyst

Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Tatsuya Kobayashi, Ph.D., M.D.

Title
Institution
Department
Address
Phone
Fax

Overview
Skeletal development, mouse genetics, chondrocytes, regulatory mechanisms for gene expression in the skeletal system, microRNAs

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 3R01AR056645-08S1 (KOBAYASHI, TATSUYA) Jul 1, 2018 - Feb 28, 2020
    NIH
    Role of miR-17-92 miRNAs in skeletal development and bone homeostasis
    Role: Principal Investigator
  2. SG-0090-13 (Tatsuya Kobayashi) Jul 1, 2013 - Sep 30, 2015
    HSCI
    Characterization and manipulation of articular cartilage chondrocytes as stem/progenitor cells
    Role: PI
  3. R01AR056645 (KOBAYASHI, TATSUYA) Apr 1, 2010 - Feb 28, 2021
    NIH
    Role of miR-17-92 miRNAs in skeletal development and bone homeostasis
    Role: Principal Investigator
  4. R21AR057134 (KOBAYASHI, TATSUYA) Apr 1, 2009 - Mar 31, 2012
    NIH/NIAMS
    Role of let-7 microRNAs in skeletal development
    Role: Principal Investigator
  5. R21AR054500 (KOBAYASHI, TATSUYA) Apr 1, 2007 - Sep 30, 2009
    NIH/NIAMS
    Small RNAs in skeletogenesis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Grigelioniene G, Suzuki HI, Taylan F, Mirzamohammadi F, Borochowitz Z, Ayturk AM, Tzur S, Horemuzova E, Lindstrand A, Weis MA, Grigelionis G, Hammarsjö A, Marsk E, Nordgren A, Nordenskjöld M, Eyer DR, Warman ML, Nishimura G, Sharp PA and Kobayashi T. . Gain-of-function mutation of microRNA-140 in human skeletal dysplasia. in press. 2019.
  2. Ambrozkiewicz MC, Schwark M, Kishimoto-Suga M, Borisova E, Hori K, Salazar-Lázaro A, Rusanova A, Altas B, Piepkorn L, Bessa P, Schaub T, Zhang X, Rabe T, Ripamonti S, Rosário M, Akiyama H, Jahn O, Kobayashi T, Hoshino M, Tarabykin V, Kawabe H. Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140. Neuron. 2018 Oct 30. PMID: 30392800.
    View in: PubMed
  3. Papaioannou G, Kozlova A, Kobayashi T. Curr Mol Bio Rep. miRNA Regulation of Chondrogenesis. 2018; 4(4):208-217.
  4. Kobayashi T, Kozlova A. Lin28a overexpression reveals the role of Erk signaling in articular cartilage development. Development. 2018 08 02; 145(15). PMID: 30042178.
    View in: PubMed
  5. Suzuki HI, Spengler RM, Grigelioniene G, Kobayashi T, Sharp PA. Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics. Nat Genet. 2018 May; 50(5):657-661. PMID: 29662165.
    View in: PubMed
  6. Mirzamohammadi F, Kozlova A, Papaioannou G, Paltrinieri E, Ayturk UM, Kobayashi T. Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models. Nat Commun. 2018 04 10; 9(1):1352. PMID: 29636449.
    View in: PubMed
  7. Papaioannou G, Mirzamohammadi F, Kobayashi T. Ras signaling regulates osteoprogenitor cell proliferation and bone formation. Cell Death Dis. 2016 10 13; 7(10):e2405. PMID: 27735946.
    View in: PubMed
  8. Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-ß signalling. Nat Commun. 2016 06 22; 7:12047. PMID: 27329220.
    View in: PubMed
  9. Kong L, Zhao YP, Tian QY, Feng JQ, Kobayashi T, Merregaert J, Liu CJ. Extracellular matrix protein 1, a direct targeting molecule of parathyroid hormone-related peptide, negatively regulates chondrogenesis and endochondral ossification via associating with progranulin growth factor. FASEB J. 2016 08; 30(8):2741-54. PMID: 27075243; PMCID: PMC4970607 [Available on 08/01/17].
  10. Fan Y, Bi R, Densmore MJ, Sato T, Kobayashi T, Yuan Q, Zhou X, Erben RG, Lanske B. Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. FASEB J. 2016 Jan; 30(1):428-40. PMID: 26428657; PMCID: PMC4684518 [Available on 01/01/17].
  11. Nakamura Y, Kikugawa S, Seki S, Takahata M, Iwasaki N, Terai H, Matsubara M, Fujioka F, Inagaki H, Kobayashi T, Kimura T, Kurahashi H, Kato H. PCSK5 mutation in a patient with the VACTERL association. BMC Res Notes. 2015 Jun 09; 8:228. PMID: 26055999; PMCID: PMC4467638.
  12. Hirai T, Kobayashi T, Nishimori S, Karaplis AC, Goltzman D, Kronenberg HM. Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis. Endocrinology. 2015 Aug; 156(8):2774-80. PMID: 26052897; PMCID: PMC4511135.
  13. Papaioannou G, Mirzamohammadi F, Lisse TS, Nishimori S, Wein MN, Kobayashi T. MicroRNA-140 Provides Robustness to the Regulation of Hypertrophic Chondrocyte Differentiation by the PTHrP-HDAC4 Pathway. J Bone Miner Res. 2015 Jun; 30(6):1044-52. PMID: 25529628.
    View in: PubMed
  14. Kobayashi T, Papaioannou G, Mirzamohammadi F, Kozhemyakina E, Zhang M, Blelloch R, Chong MW. Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage. Osteoarthritis Cartilage. 2015 Jul; 23(7):1214-20. PMID: 25707934; PMCID: PMC4470813.
  15. Mirzamohammadi F, Papaioannou G, Kobayashi T. MicroRNAs in cartilage development, homeostasis, and disease. Curr Osteoporos Rep. 2014 Dec; 12(4):410-9. PMID: 25091054; PMCID: PMC4234170.
  16. Papaioannou G, Mirzamohammadi F, Kobayashi T. MicroRNAs involved in bone formation. Cell Mol Life Sci. 2014 Dec; 71(24):4747-61. PMID: 25108446; PMCID: PMC4234685.
  17. Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, Offermanns S, Weinstein LS, Kronenberg HM. G-protein stimulatory subunit alpha and Gq/11a G-proteins are both required to maintain quiescent stem-like chondrocytes. Nat Commun. 2014 Apr 30; 5:3673. PMID: 24781502; PMCID: PMC4154354.
  18. Kuchimaru T, Hoshino T, Aikawa T, Yasuda H, Kobayashi T, Kadonosono T, Kizaka-Kondoh S. Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia. Cancer Sci. 2014 May; 105(5):553-9. PMID: 24597654; PMCID: PMC4317828.
  19. Kobayashi T, Kronenberg HM. Overview of skeletal development. Methods Mol Biol. 2014; 1130:3-12. PMID: 24482161.
    View in: PubMed
  20. Papaioannou G, Inloes JB, Nakamura Y, Paltrinieri E, Kobayashi T. let-7 and miR-140 microRNAs coordinately regulate skeletal development. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):E3291-300. PMID: 23940373; PMCID: PMC3761644.
  21. Park D, Spencer JA, Koh BI, Kobayashi T, Fujisaki J, Clemens TL, Lin CP, Kronenberg HM, Scadden DT. Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell. 2012 Mar 02; 10(3):259-72. PMID: 22385654; PMCID: PMC3652251.
  22. Nakamura Y, He X, Kato H, Wakitani S, Kobayashi T, Watanabe S, Iida A, Tahara H, Warman ML, Watanapokasin R, Postlethwait JH. Sox9 is upstream of microRNA-140 in cartilage. Appl Biochem Biotechnol. 2012 Jan; 166(1):64-71. PMID: 22052544; PMCID: PMC3774128.
  23. Nakamura Y, Inloes JB, Katagiri T, Kobayashi T. Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling. Mol Cell Biol. 2011 Jul; 31(14):3019-28. PMID: 21576357; PMCID: PMC3133397.
  24. Powell WF, Barry KJ, Tulum I, Kobayashi T, Harris SE, Bringhurst FR, Pajevic PD. Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses. J Endocrinol. 2011 Apr; 209(1):21-32. PMID: 21220409; PMCID: PMC3783949.
  25. Hirai T, Chagin AS, Kobayashi T, Mackem S, Kronenberg HM. Parathyroid hormone/parathyroid hormone-related protein receptor signaling is required for maintenance of the growth plate in postnatal life. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):191-6. PMID: 21173257; PMCID: PMC3017151.
  26. Tawfeek H, Bedi B, Li JY, Adams J, Kobayashi T, Weitzmann MN, Kronenberg HM, Pacifici R. Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss. PLoS One. 2010 Aug 20; 5(8):e12290. PMID: 20808842; PMCID: PMC2924900.
  27. Maes C, Kobayashi T, Selig MK, Torrekens S, Roth SI, Mackem S, Carmeliet G, Kronenberg HM. Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell. 2010 Aug 17; 19(2):329-44. PMID: 20708594; PMCID: PMC3540406.
  28. Raaijmakers MH, Mukherjee S, Guo S, Zhang S, Kobayashi T, Schoonmaker JA, Ebert BL, Al-Shahrour F, Hasserjian RP, Scadden EO, Aung Z, Matza M, Merkenschlager M, Lin C, Rommens JM, Scadden DT. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature. 2010 Apr 08; 464(7290):852-7. PMID: 20305640; PMCID: PMC3422863.
  29. Kamiya N, Kobayashi T, Mochida Y, Yu PB, Yamauchi M, Kronenberg HM, Mishina Y. Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts. J Bone Miner Res. 2010 Feb; 25(2):200-10. PMID: 19874086; PMCID: PMC3153381.
  30. Kobayashi T. [Hormones and osteoporosis update. Mechanisms of anabolic and catabolic effects of PTH on bone]. Clin Calcium. 2009 Jul; 19(7):911-8. PMID: 19567985.
    View in: PubMed
  31. Bai XH, Wang DW, Kong L, Zhang Y, Luan Y, Kobayashi T, Kronenberg HM, Yu XP, Liu CJ. ADAMTS-7, a direct target of PTHrP, adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor. Mol Cell Biol. 2009 Aug; 29(15):4201-19. PMID: 19487464; PMCID: PMC2715794.
  32. Miclea RL, Karperien M, Bosch CA, van der Horst G, van der Valk MA, Kobayashi T, Kronenberg HM, Rawadi G, Akçakaya P, Löwik CW, Fodde R, Wit JM, Robanus-Maandag EC. Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors. BMC Dev Biol. 2009 Apr 08; 9:26. PMID: 19356224; PMCID: PMC2678105.
  33. Kamiya N, Ye L, Kobayashi T, Lucas DJ, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y. Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass. J Bone Miner Res. 2008 Dec; 23(12):2007-17. PMID: 18684091; PMCID: PMC2686924.
  34. Kamiya N, Ye L, Kobayashi T, Mochida Y, Yamauchi M, Kronenberg HM, Feng JQ, Mishina Y. BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway. Development. 2008 Nov; 135(22):3801-11. PMID: 18927151.
    View in: PubMed
  35. Nakamura Y, He X, Kobayashi T, Yan YL, Postlethwait JH, Warman ML. Unique roles of microRNA140 and its host gene WWP2 in cartilage biology. J Musculoskelet Neuronal Interact. 2008 Oct-Dec; 8(4):321-2. PMID: 19147957; PMCID: PMC2757261.
  36. Hilton MJ, Tu X, Wu X, Bai S, Zhao H, Kobayashi T, Kronenberg HM, Teitelbaum SL, Ross FP, Kopan R, Long F. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med. 2008 Mar; 14(3):306-14. PMID: 18297083; PMCID: PMC2740725.
  37. Kobayashi T, Lu J, Cobb BS, Rodda SJ, McMahon AP, Schipani E, Merkenschlager M, Kronenberg HM. Dicer-dependent pathways regulate chondrocyte proliferation and differentiation. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):1949-54. PMID: 18238902; PMCID: PMC2538863.
  38. Maes C, Kobayashi T, Kronenberg HM. A novel transgenic mouse model to study the osteoblast lineage in vivo. Ann N Y Acad Sci. 2007 Nov; 1116:149-64. PMID: 18083926.
    View in: PubMed
  39. Kobayashi T, Lyons KM, McMahon AP, Kronenberg HM. BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18023-7. PMID: 16322106; PMCID: PMC1312369.
  40. Miao D, He B, Jiang Y, Kobayashi T, Sorocéanu MA, Zhao J, Su H, Tong X, Amizuka N, Gupta A, Genant HK, Kronenberg HM, Goltzman D, Karaplis AC. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J Clin Invest. 2005 Sep; 115(9):2402-11. PMID: 16138191; PMCID: PMC1193882.
  41. Kobayashi T, Kronenberg HM, Foley J. Reduced expression of the PTH/PTHrP receptor during development of the mammary gland influences the function of the nipple during lactation. Dev Dyn. 2005 Jul; 233(3):794-803. PMID: 15880431.
    View in: PubMed
  42. Kobayashi T, Soegiarto DW, Yang Y, Lanske B, Schipani E, McMahon AP, Kronenberg HM. Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP. J Clin Invest. 2005 Jul; 115(7):1734-42. PMID: 15951842; PMCID: PMC1143590.
  43. Kobayashi T, Kronenberg H. Minireview: transcriptional regulation in development of bone. Endocrinology. 2005 Mar; 146(3):1012-7. PMID: 15604211.
    View in: PubMed
  44. Sakamoto A, Chen M, Kobayashi T, Kronenberg HM, Weinstein LS. Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formation. J Bone Miner Res. 2005 Apr; 20(4):663-71. PMID: 15765186.
    View in: PubMed
  45. Kanatani M, Sugimoto T, Sowa H, Kobayashi T, Kanzawa M, Chihara K. Thyroid hormone stimulates osteoclast differentiation by a mechanism independent of RANKL-RANK interaction. J Cell Physiol. 2004 Oct; 201(1):17-25. PMID: 15281085.
    View in: PubMed
  46. Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development. 2004 May; 131(10):2497-508. PMID: 15128677.
    View in: PubMed
  47. Shin HI, Divieti P, Sims NA, Kobayashi T, Miao D, Karaplis AC, Baron R, Bringhurst R, Kronenberg HM. Gp130-mediated signaling is necessary for normal osteoblastic function in vivo and in vitro. Endocrinology. 2004 Mar; 145(3):1376-85. PMID: 14617570.
    View in: PubMed
  48. Guha U, Gomes WA, Kobayashi T, Pestell RG, Kessler JA. In vivo evidence that BMP signaling is necessary for apoptosis in the mouse limb. Dev Biol. 2002 Sep 01; 249(1):108-20. PMID: 12217322.
    View in: PubMed
  49. Kobayashi T, Chung UI, Schipani E, Starbuck M, Karsenty G, Katagiri T, Goad DL, Lanske B, Kronenberg HM. PTHrP and Indian hedgehog control differentiation of growth plate chondrocytes at multiple steps. Development. 2002 Jun; 129(12):2977-86. PMID: 12050144.
    View in: PubMed
  50. Kobayashi T, Sugimoto T, Kanzawa M, Chihara K. Identification of an enhancer sequence in 5'-flanking region of 1A exon of mouse liver/bone/kidney-type alkaline phosphatase gene. Biochem Mol Biol Int. 1998 Apr; 44(4):683-91. PMID: 9584982.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Kobayashi's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (258)
Explore
_
Co-Authors (18)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Tool Page Footer - Harvard Catalyst Tool Page Footer – Harvard Catalyst
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.