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Mary-Elizabeth Patti, M.D.

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Mentoring
Available: 10/09/18, Expires: 09/30/19

Obesity and type 2 diabetes (T2D) are major public health challenges for our generation. Unfortunately, there are no simple answers for the dual epidemics of obesity and T2D. Novel insights and approaches on many fronts are required. One new approach to target disease risk arises from the recognition that risk patterns for both obesity and T2D can originate as a consequence of alterations in growth and metabolism during critical windows of prenatal and early postnatal development. Moreover, obesity, prediabetes, and diabetes in individuals of reproductive age can initiate a vicious cycle, propagating risk to subsequent generations via non-genetic, or epi-genetic and metabolic mechanisms. Thus, understanding mechanisms mediating these effects is an important scientific and clinical goal. More importantly, this concept provides the hope that identification of high-risk individuals for targeted intervention during early childhood and subsequent reproductive life may limit vicious cycles of metabolic risk. Our laboratory is studying mechanisms by which altered nutrition and metabolism can impact offspring, and to identify methods to reverse the impact of adverse exposures on offspring. Using our mouse model, we have demonstrated that mice exposed to transient nutritional alterations during their development go on to develop progressive glucose intolerance, insulin secretory dysfunction, reduced muscle mass, and obesity as adults – the classic phenotype of diabetes risk. Moreover, these F1 mice (both males and females) yield F2 offspring with abnormal glucose tolerance and increased adiposity. These data suggest that environmental exposures alter germ cell epigenetic marks, which may contribute to altered development in F2 offspring and increase risk of chronic disease. We are now testing (in both mice and humans!) whether interventions such as diet, activity, and medications which target specific pathways may reduce transmission of disease risk from one generation to the next.

Available: 10/10/18, Expires: 10/17/19

Bariatric surgery has emerged as a potent strategy to reduce not only body weight but also to reduce plasma glucose levels and induce remission of diabetes, even allowing medication withdrawal. Some patients even develop low blood glucose (hypoglycemia) after bariatric surgery. THese exciting data underscore the importance of gastrointestinal regulation of whole-body metabolism, via pathways which remain incompletely understood. In this project, we are studying the impact of candidate circulating proteins identified via proteomic and metabolomic studies in humans with type 2 diabetes who have had either bariatric surgery or medical management. These candidate proteins are being overexpressed in mice via several approaches, to determine their effect on metabolism, including insulin secretion, in the mouse. The student would work with a postdoctoral fellow in the laboratory to learn needed techniques and analysis of omics data. The student would also have opportunities to interface with clinical studies in this area, as guided by students' interests.

Available: 10/15/18, Expires: 10/15/19

Obesity and type 2 diabetes (T2D) are major public health challenges for our generation. Particularly concerning is the rise in obesity in the pediatric population, the anticipated rise in premature morbidity and mortality with long-standing obesity and costs associated with obesity-related. In parallel, recent projections suggest that prevalence of diabetes is likely to increase to over 25% of the US population by 2050, yielding enormous tolls at individual, public health, and economic levels. Unfortunately, there are no simple answers for the dual epidemics of obesity and T2D. Novel insights and approaches on many fronts are required.

Risk patterns for both obesity and T2D can originate as a consequence of alterations in growth and metabolism during critical windows of prenatal and early postnatal development. Moreover, obesity, prediabetes, and diabetes in individuals of reproductive age can initiate a vicious cycle, propagating risk to subsequent generations via non-genetic, or epi-genetic and metabolic mechanisms. Thus, understanding mechanisms mediating these effects is an important scientific and clinical goal. More importantly, this concept provides the hope that identification of high-risk individuals for targeted intervention during early childhood and subsequent reproductive life may limit vicious cycles of metabolic risk.

One example of nutritionally-mediated transmission of metabolic phenotypes is provided from our laboratory’s mouse model in which healthy pregnant mothers (F0) are exposed to modified nutrition during the last third of pregnancy. Their offspring (F1) have a modest 15% reduction in birth weight and experience early postnatal “catch-up growth.” Despite normal chow diet after weaning, these UN-exposed mice go on to develop progressive glucose intolerance, insulin secretory dysfunction, reduced muscle mass, and obesity as adults. UN exposed mice have upregulation of lipogenic gene expression in both liver and adipose, increased adipocyte size, and reduced mitochondrial DNA content. We have recently demonstrated that UN-exposed mice also have reduced numbers of myogenic precursor cells, suggesting the possibility that alterations in key stem cell populations may alter developmental trajectories and modify tissue structure/function and repair. The goal of the current study is to examine patterns of transcriptional dysregulation in myoblasts isolated from skeletal muscle from at-risk mice, and in parallel, to identify potential epigenetic mediators resulting from exposure to nutritional stress during pregnancy.

Available: 10/11/18, Expires: 10/17/19

Closed loop insulin pumps are rapidly moving toward reality for clinical diabetes care. While integrationwith continuous glucose monitoring together with integrative algorithms has allowed great improvement in glucose control, factors such as meal initiation, exercise, stress and insulin boluses previously delivered are variables which need to be incorporated into decision-making algorithms to guide improved insulin delivery. This project, a collaboration with Harvard engineers, will inform the development of new insulin delivery algorithms for safer more effective diabetes treatment.


Research
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Molecular Phenotyping and Genotyping Core (JDC) - Core services (15), Instruments (16) and Software (2)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Osataphan S, Macchi C, Singhal G, Chimene-Weiss J, Sales V, Kozuka C, Dreyfuss JM, Pan H, Tangcharoenpaisan Y, Morningstar J, Gerszten R, Patti ME. SGLT2 inhibition reprograms systemic metabolism via FGF21-dependent and -independent mechanisms. JCI Insight. 2019 Mar 07; 4(5). PMID: 30843877.
    Citations:    
  2. Franquet E, Watts G, Kolodny GM, Goldfine AB, Patti ME. PET-CT reveals increased intestinal glucose uptake after gastric surgery. Surg Obes Relat Dis. 2019 Jan 25. PMID: 30773442.
    Citations:    
  3. Stanford KI, Rasmussen M, Baer LA, Lehnig AC, Rowland LA, White JD, So K, De Sousa-Coelho AL, Hirshman MF, Patti ME, Rando OJ, Goodyear LJ. Paternal Exercise Improves Glucose Metabolism in Adult Offspring. Diabetes. 2018 12; 67(12):2530-2540. PMID: 30344184.
    Citations:    Fields:    
  4. Rosen ED, Kaestner KH, Natarajan R, Patti ME, Sallari R, Sander M, Susztak K. Epigenetics and Epigenomics: Implications for Diabetes and Obesity. Diabetes. 2018 10; 67(10):1923-1931. PMID: 30237160.
    Citations:    Fields:    Translation:HumansCells
  5. Adachi Y, De Sousa-Coelho AL, Harata I, Aoun C, Weimer S, Shi X, Gonzalez Herrera KN, Takahashi H, Doherty C, Noguchi Y, Goodyear LJ, Haigis MC, Gerszten RE, Patti ME. l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Mol Metab. 2018 Nov; 17:61-70. PMID: 30190193.
    Citations:    Fields:    
  6. Grizales AM, Patti ME, Lin AP, Beckman JA, Sahni VA, Cloutier E, Fowler KM, Dreyfuss JM, Pan H, Kozuka C, Lee A, Basu R, Pober DM, Gerszten RE, Goldfine AB. Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes. J Clin Endocrinol Metab. 2018 08 01; 103(8):3038-3049. PMID: 29860335.
    Citations:    Fields:    
  7. Salehi M, Vella A, McLaughlin T, Patti ME. Hypoglycemia After Gastric Bypass Surgery: Current Concepts and Controversies. J Clin Endocrinol Metab. 2018 08 01; 103(8):2815-2826. PMID: 30101281.
    Citations:    Fields:    
  8. Gonzalez-Franquesa A, Patti ME. Squeezing Flux Out of Fat. Trends Endocrinol Metab. 2018 04; 29(4):201-202. PMID: 29409712.
    Citations:    Fields:    Translation:HumansCells
  9. Laguna Sanz AJ, Mulla CM, Fowler KM, Cloutier E, Goldfine AB, Newswanger B, Cummins M, Deshpande S, Prestrelski SJ, Strange P, Zisser H, Doyle FJ, Dassau E, Patti ME. Design and Clinical Evaluation of a Novel Low-Glucose Prediction Algorithm with Mini-Dose Stable Glucagon Delivery in Post-Bariatric Hypoglycemia. Diabetes Technol Ther. 2018 02; 20(2):127-139. PMID: 29355439.
    Citations:    Fields:    Translation:Humans
  10. Arora I, Patti ME. Can reversal of RYGB also reverse hypoglycemia? Mol Metab. 2018 03; 9:1-3. PMID: 29371089.
    Citations:    Fields:    Translation:Humans
  11. Fernandes GW, Bocco BMLC, Fonseca TL, McAninch EA, Jo S, Lartey LJ, O-Sullivan I, Unterman TG, Preite NZ, Voigt RM, Forsyth CB, Keshavarzian A, Sinkó R, Goldfine AB, Patti ME, Ribeiro MO, Gereben B, Bianco AC. The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia. Cell Rep. 2018 01 09; 22(2):523-534. PMID: 29320745.
    Citations: 1     Fields:    
  12. Patti ME. LETTER TO THE EDITOR. Endocr Pract. 2017 10; 23(10):1275. PMID: 29045187.
    Citations:    Fields:    Translation:Humans
  13. Mulla CM, Middelbeek RJW, Patti ME. Mechanisms of weight loss and improved metabolism following bariatric surgery. Ann N Y Acad Sci. 2018 Jan; 1411(1):53-64. PMID: 28868615.
    Citations: 3     Fields:    
  14. Ma H, Sales VM, Wolf AR, Subramanian S, Matthews TJ, Chen M, Sharma A, Gall W, Kulik W, Cohen DE, Adachi Y, Griffin NW, Gordon JI, Patti ME, Isganaitis E. Attenuated Effects of Bile Acids on Glucose Metabolism and Insulin Sensitivity in a Male Mouse Model of Prenatal Undernutrition. Endocrinology. 2017 08 01; 158(8):2441-2452. PMID: 28637315.
    Citations:    Fields:    Translation:Animals
  15. Patti ME, Goldfine AB, Hu J, Hoem D, Molven A, Goldsmith J, Schwesinger WH, La Rosa S, Folli F, Kulkarni RN. Heterogeneity of proliferative markers in pancreatic ß-cells of patients with severe hypoglycemia following Roux-en-Y gastric bypass. Acta Diabetol. 2017 Aug; 54(8):737-747. PMID: 28512677.
    Citations:    Fields:    Translation:HumansCells
  16. Sales VM, Ferguson-Smith AC, Patti ME. Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations. Cell Metab. 2017 03 07; 25(3):559-571. PMID: 28273478.
    Citations: 7     Fields:    Translation:HumansAnimals
  17. Suhl E, Anderson-Haynes SE, Mulla C, Patti ME. Medical nutrition therapy for post-bariatric hypoglycemia: practical insights. Surg Obes Relat Dis. 2017 May; 13(5):888-896. PMID: 28392017.
    Citations: 1     Fields:    Translation:Humans
  18. Gonzalez-Franquesa A, Patti ME. Insulin Resistance and Mitochondrial Dysfunction. Adv Exp Med Biol. 2017; 982:465-520. PMID: 28551803.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  19. Costa SM, Isganaitis E, Matthews TJ, Hughes K, Daher G, Dreyfuss JM, da Silva GA, Patti ME. Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells. Int J Obes (Lond). 2016 11; 40(11):1627-1634. PMID: 27531045.
    Citations: 3     Fields:    Translation:HumansCells
  20. Lerin C, Goldfine AB, Boes T, Liu M, Kasif S, Dreyfuss JM, De Sousa-Coelho AL, Daher G, Manoli I, Sysol JR, Isganaitis E, Jessen N, Goodyear LJ, Beebe K, Gall W, Venditti CP, Patti ME. Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism. Mol Metab. 2016 Oct; 5(10):926-936. PMID: 27689005.
    Citations: 15     Fields:    
  21. Gonzalez-Franquesa A, Burkart AM, Isganaitis E, Patti ME. What Have Metabolomics Approaches Taught Us About Type 2 Diabetes? Curr Diab Rep. 2016 08; 16(8):74. PMID: 27319324.
    Citations: 3     Fields:    Translation:Humans
  22. Goldfine AB, Patti ME. How common is hypoglycemia after gastric bypass? Obesity (Silver Spring). 2016 06; 24(6):1210-1. PMID: 27225595.
    Citations: 2     Fields:    Translation:Humans
  23. Middelbeek RJ, Brown FM, Patti ME. Weight Loss and Health Status after Bariatric Surgery in Adolescents. N Engl J Med. 2016 05 19; 374(20):1988-9. PMID: 27192680.
    Citations:    Fields:    Translation:Humans
  24. Mulla CM, Storino A, Yee EU, Lautz D, Sawnhey MS, Moser AJ, Patti ME. Insulinoma After Bariatric Surgery: Diagnostic Dilemma and Therapeutic Approaches. Obes Surg. 2016 Apr; 26(4):874-81. PMID: 26846121; PMCID: PMC4814298.
    Citations: 3     Fields:    Translation:Humans
  25. Burkart AM, Tan K, Warren L, Iovino S, Hughes KJ, Kahn CR, Patti ME. Insulin Resistance in Human iPS Cells Reduces Mitochondrial Size and Function. Sci Rep. 2016 Mar 07; 6:22788. PMID: 26948272; PMCID: PMC4780029.
    Citations: 7     Fields:    Translation:HumansCells
  26. Ejaz A, Martinez-Guino L, Goldfine AB, Ribas-Aulinas F, De Nigris V, Ribó S, Gonzalez-Franquesa A, Garcia-Roves PM, Li E, Dreyfuss JM, Gall W, Kim JK, Bottiglieri T, Villarroya F, Gerszten RE, Patti ME, Lerin C. Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice. Diabetes. 2016 04; 65(4):902-12. PMID: 26858359; PMCID: PMC4806659.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  27. Iovino S, Burkart AM, Warren L, Patti ME, Kahn CR. Myotubes derived from human-induced pluripotent stem cells mirror in vivo insulin resistance. Proc Natl Acad Sci U S A. 2016 Feb 16; 113(7):1889-94. PMID: 26831110; PMCID: PMC4763759.
    Citations: 4     Fields:    Translation:HumansCells
  28. Makimura H, Stanley TL, Suresh C, De Sousa-Coelho AL, Frontera WR, Syu S, Braun LR, Looby SE, Feldpausch MN, Torriani M, Lee H, Patti ME, Grinspoon SK. Metabolic Effects of Long-Term Reduction in Free Fatty Acids With Acipimox in Obesity: A Randomized Trial. J Clin Endocrinol Metab. 2016 Mar; 101(3):1123-33. PMID: 26691888; PMCID: PMC4803166.
    Citations: 3     Fields:    Translation:HumansCells
  29. Patti ME, Goldfine AB. The rollercoaster of post-bariatric hypoglycaemia. Lancet Diabetes Endocrinol. 2016 Feb; 4(2):94-6. PMID: 26701701.
    Citations: 1     Fields:    Translation:Humans
  30. Goldfine AB, Patti ME. New lessons from gastric bypass: Impact of glucose-independent islet function. Obesity (Silver Spring). 2015 Oct; 23(10):1942-3. PMID: 26348724; PMCID: PMC4586903.
    Citations:    Fields:    Translation:HumansCells
  31. Middelbeek RJ, James-Todd T, Cavallerano JD, Schlossman DK, Patti ME, Brown FM. Gastric Bypass Surgery in Severely Obese Women With Type 1 Diabetes: Anthropometric and Cardiometabolic Effects at 1 and 5 Years Postsurgery. Diabetes Care. 2015 Jul; 38(7):e104-5. PMID: 26106230; PMCID: PMC4876744.
    Citations: 3     Fields:    
  32. Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper ME. Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep. 2015 Apr 10; 35(3). PMID: 26182362; PMCID: PMC4613697.
    Citations: 11     Fields:    Translation:AnimalsCells
  33. Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper ME. Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep. 2015 Apr 10. PMID: 25860649.
    Citations:    
  34. Balhara B, Burkart A, Topcu V, Lee YK, Cowan C, Kahn CR, Patti ME. Severe insulin resistance alters metabolism in mesenchymal progenitor cells. Endocrinology. 2015 Jun; 156(6):2039-48. PMID: 25811318; PMCID: PMC4430624.
    Citations: 2     Fields:    Translation:HumansCells
  35. Isganaitis E, Rifas-Shiman SL, Oken E, Dreyfuss JM, Gall W, Gillman MW, Patti ME. Associations of cord blood metabolites with early childhood obesity risk. Int J Obes (Lond). 2015 Jul; 39(7):1041-8. PMID: 25804930; PMCID: PMC4496296.
    Citations: 9     Fields:    Translation:Humans
  36. Patti ME, Li P, Goldfine AB. Insulin response to oral stimuli and glucose effectiveness increased in neuroglycopenia following gastric bypass. Obesity (Silver Spring). 2015 Apr; 23(4):798-807. PMID: 25755084.
    Citations: 11     Fields:    Translation:HumansCells
  37. Hivert MF, Perng W, Watkins SM, Newgard CS, Kenny LC, Kristal BS, Patti ME, Isganaitis E, DeMeo DL, Oken E, Gillman MW. Metabolomics in the developmental origins of obesity and its cardiometabolic consequences. J Dev Orig Health Dis. 2015 Apr; 6(2):65-78. PMID: 25631626; PMCID: PMC4406410.
    Citations: 3     Fields:    Translation:HumansAnimals
  38. McAninch EA, Jo S, Preite NZ, Farkas E, Mohácsik P, Fekete C, Egri P, Gereben B, Li Y, Deng Y, Patti ME, Zevenbergen C, Peeters RP, Mash DC, Bianco AC. Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes. J Clin Endocrinol Metab. 2015 Mar; 100(3):920-33. PMID: 25569702; PMCID: PMC4333048.
    Citations: 10     Fields:    Translation:HumansCells
  39. Nogiec C, Burkart A, Dreyfuss JM, Lerin C, Kasif S, Patti ME. Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes. Mol Metab. 2015 Mar; 4(3):151-63. PMID: 25737951; PMCID: PMC4338313.
    Citations: 8     Fields:    
  40. Perng W, Gillman MW, Fleisch AF, Michalek RD, Watkins SM, Isganaitis E, Patti ME, Oken E. Metabolomic profiles and childhood obesity. Obesity (Silver Spring). 2014 Dec; 22(12):2570-8. PMID: 25251340; PMCID: PMC4236243.
    Citations: 28     Fields:    Translation:Humans
  41. Robertson RP, Bogachus LD, Oseid E, Parazzoli S, Patti ME, Rickels MR, Schuetz C, Dunn T, Pruett T, Balamurugan AN, Sutherland DE, Beilman G, Bellin MD. Assessment of ß-cell mass and a- and ß-cell survival and function by arginine stimulation in human autologous islet recipients. Diabetes. 2015 Feb; 64(2):565-72. PMID: 25187365; PMCID: PMC4303963.
    Citations: 16     Fields:    Translation:HumansCells
  42. Middelbeek RJ, James-Todd T, Patti ME, Brown FM. Short-term insulin requirements following gastric bypass surgery in severely obese women with type 1 diabetes. Obes Surg. 2014 Sep; 24(9):1442-6. PMID: 24668543; PMCID: PMC4122809.
    Citations: 11     Fields:    Translation:Humans
  43. Bellin MD, Parazzoli S, Oseid E, Bogachus LD, Schuetz C, Patti ME, Dunn T, Pruett T, Balamurugan AN, Hering B, Beilman G, Sutherland DE, Robertson RP. Defective glucagon secretion during hypoglycemia after intrahepatic but not nonhepatic islet autotransplantation. Am J Transplant. 2014 Aug; 14(8):1880-6. PMID: 25039984; PMCID: PMC4440232.
    Citations: 13     Fields:    Translation:Humans
  44. Iovino S, Burkart AM, Kriauciunas K, Warren L, Hughes KJ, Molla M, Lee YK, Patti ME, Kahn CR. Genetic insulin resistance is a potent regulator of gene expression and proliferation in human iPS cells. Diabetes. 2014 Dec; 63(12):4130-42. PMID: 25059784; PMCID: PMC4238001.
    Citations: 10     Fields:    Translation:HumansCells
  45. Ma H, Patti ME. Bile acids, obesity, and the metabolic syndrome. Best Pract Res Clin Gastroenterol. 2014 Aug; 28(4):573-83. PMID: 25194176; PMCID: PMC4159616.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  46. Beauchamp B, Ghosh S, Dysart MW, Kanaan GN, Chu A, Blais A, Rajamanickam K, Tsai EC, Patti ME, Harper ME. Low birth weight is associated with adiposity, impaired skeletal muscle energetics and weight loss resistance in mice. Int J Obes (Lond). 2015 Apr; 39(4):702-11. PMID: 25091727.
    Citations: 8     Fields:    Translation:HumansAnimals
  47. Radford EJ, Ito M, Shi H, Corish JA, Yamazawa K, Isganaitis E, Seisenberger S, Hore TA, Reik W, Erkek S, Peters AHFM, Patti ME, Ferguson-Smith AC. In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. Science. 2014 Aug 15; 345(6198):1255903. PMID: 25011554.
    Citations: 118     Fields:    Translation:AnimalsCells
  48. Goldfine AB, Patti ME. Diabetes improvement following Roux-en-Y gastric bypass: understanding dynamic changes in insulin secretion and action. Diabetes. 2014 May; 63(5):1454-6. PMID: 24757197.
    Citations: 4     Fields:    Translation:Humans
  49. Patti ME, Goldfine AB. Hypoglycemia after gastric bypass: the dark side of GLP-1. Gastroenterology. 2014 Mar; 146(3):605-8. PMID: 24468184.
    Citations: 9     Fields:    Translation:Humans
  50. Wewalka M, Patti ME, Barbato C, Houten SM, Goldfine AB. Fasting serum taurine-conjugated bile acids are elevated in type 2 diabetes and do not change with intensification of insulin. J Clin Endocrinol Metab. 2014 Apr; 99(4):1442-51. PMID: 24432996.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  51. Isganaitis E, Woo M, Ma H, Chen M, Kong W, Lytras A, Sales V, Decoste-Lopez J, Lee KJ, Leatherwood C, Lee D, Fitzpatrick C, Gall W, Watkins S, Patti ME. Developmental programming by maternal insulin resistance: hyperinsulinemia, glucose intolerance, and dysregulated lipid metabolism in male offspring of insulin-resistant mice. Diabetes. 2014 Feb; 63(2):688-700. PMID: 24186867; PMCID: PMC3900545.
    Citations: 15     Fields:    Translation:Animals
  52. Goldfine AB, Patti ME. Diabetes: Bariatric surgery for T2DM--cure, or remission and relapse? Nat Rev Endocrinol. 2014 Jan; 10(1):8-9. PMID: 24165996; PMCID: PMC4160734.
    Citations: 1     Fields:    Translation:Humans
  53. Colaneri A, Wang T, Pagadala V, Kittur J, Staffa NG, Peddada SD, Isganaitis E, Patti ME, Birnbaumer L. A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming. PLoS One. 2013; 8(9):e72670. PMID: 24069155; PMCID: PMC3771925.
    Citations: 8     Fields:    Translation:AnimalsCells
  54. Patti ME. Reducing maternal weight improves offspring metabolism and alters (or modulates) methylation. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):12859-60. PMID: 23884649; PMCID: PMC3740829.
    Citations: 3     Fields:    Translation:HumansCells
  55. Patti ME. Intergenerational programming of metabolic disease: evidence from human populations and experimental animal models. Cell Mol Life Sci. 2013 May; 70(9):1597-608. PMID: 23435955; PMCID: PMC3625497.
    Citations: 15     Fields:    Translation:HumansAnimalsPHPublic Health
  56. Sales V, Patti ME. The Ups and Downs of Insulin Resistance and Type 2 Diabetes: Lessons from Genomic Analyses in Humans. Curr Cardiovasc Risk Rep. 2013 Feb 01; 7(1):46-59. PMID: 23459395.
    Citations: 5     
  57. Simonen M, Dali-Youcef N, Kaminska D, Venesmaa S, Käkelä P, Pääkkönen M, Hallikainen M, Kolehmainen M, Uusitupa M, Moilanen L, Laakso M, Gylling H, Patti ME, Auwerx J, Pihlajamäki J. Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass. Obes Surg. 2012 Sep; 22(9):1473-80. PMID: 22638681; PMCID: PMC4426904.
    Citations: 56     Fields:    Translation:Humans
  58. Radford EJ, Isganaitis E, Jimenez-Chillaron J, Schroeder J, Molla M, Andrews S, Didier N, Charalambous M, McEwen K, Marazzi G, Sassoon D, Patti ME, Ferguson-Smith AC. An unbiased assessment of the role of imprinted genes in an intergenerational model of developmental programming. PLoS Genet. 2012; 8(4):e1002605. PMID: 22511876.
    Citations: 44     Fields:    Translation:HumansAnimals
  59. Pihlajamäki J, Lerin C, Kaminska D, Venesmaa S, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME. Response to Brosch et al. Cell Metab. 2012 Mar 07; 15(3):267-269. PMID: 25960695.
    Citations: 2     Fields:    
  60. Pihlajamäki J, Lerin C, Itkonen P, Boes T, Floss T, Schroeder J, Dearie F, Crunkhorn S, Burak F, Jimenez-Chillaron JC, Kuulasmaa T, Miettinen P, Park PJ, Nasser I, Zhao Z, Zhang Z, Xu Y, Wurst W, Ren H, Morris AJ, Stamm S, Goldfine AB, Laakso M, Patti ME. Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis. Cell Metab. 2011 Aug 03; 14(2):208-18. PMID: 21803291; PMCID: PMC3167228.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  61. Bezy O, Tran TT, Pihlajamäki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M, Goldfine AB, Patti ME, King GL, Kahn CR. PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun; 121(6):2504-17. PMID: 21576825; PMCID: PMC3104767.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  62. Woo M, Isganaitis E, Cerletti M, Fitzpatrick C, Wagers AJ, Jimenez-Chillaron J, Patti ME. Early life nutrition modulates muscle stem cell number: implications for muscle mass and repair. Stem Cells Dev. 2011 Oct; 20(10):1763-9. PMID: 21247245; PMCID: PMC3182031.
    Citations: 27     Fields:    Translation:AnimalsCells
  63. Jin W, Goldfine AB, Boes T, Henry RR, Ciaraldi TP, Kim EY, Emecan M, Fitzpatrick C, Sen A, Shah A, Mun E, Vokes V, Schroeder J, Tatro E, Jimenez-Chillaron J, Patti ME. Increased SRF transcriptional activity in human and mouse skeletal muscle is a signature of insulin resistance. J Clin Invest. 2011 Mar; 121(3):918-29. PMID: 21393865; PMCID: PMC3049368.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  64. Halperin F, Patti ME, Skow M, Bajwa M, Goldfine AB. Continuous glucose monitoring for evaluation of glycemic excursions after gastric bypass. J Obes. 2011; 2011:869536. PMID: 21331295; PMCID: PMC3038694.
    Citations: 9     Fields:    
  65. Ferguson-Smith AC, Patti ME. You are what your dad ate. Cell Metab. 2011 Feb 02; 13(2):115-7. PMID: 21284975.
    Citations: 19     Fields:    
  66. da-Silva WS, Ribich S, Arrojo e Drigo R, Castillo M, Patti ME, Bianco AC. The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure. FEBS Lett. 2011 Feb 04; 585(3):539-44. PMID: 21237159.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  67. Goldfine AB, Gerwien RW, Kolberg JA, O'Shea S, Hamren S, Hein GP, Xu XM, Patti ME. Biomarkers in fasting serum to estimate glucose tolerance, insulin sensitivity, and insulin secretion. Clin Chem. 2011 Feb; 57(2):326-37. PMID: 21149503.
    Citations: 3     Fields:    Translation:Humans
  68. Reubi JC, Perren A, Rehmann R, Waser B, Christ E, Callery M, Goldfine AB, Patti ME. Glucagon-like peptide-1 (GLP-1) receptors are not overexpressed in pancreatic islets from patients with severe hyperinsulinaemic hypoglycaemia following gastric bypass. Diabetologia. 2010 Dec; 53(12):2641-5. PMID: 20835917.
    Citations: 12     Fields:    Translation:HumansCells
  69. Patti ME, Goldfine AB. Hypoglycaemia following gastric bypass surgery--diabetes remission in the extreme? Diabetologia. 2010 Nov; 53(11):2276-9. PMID: 20730413.
    Citations: 13     Fields:    Translation:Humans
  70. Patti ME. Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? J Clin Invest. 2010 Aug; 120(8):2646-8. PMID: 20664166; PMCID: PMC2912207.
    Citations: 2     Fields:    Translation:HumansAnimals
  71. Hall JA, Ribich S, Christoffolete MA, Simovic G, Correa-Medina M, Patti ME, Bianco AC. Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis. Endocrinology. 2010 Sep; 151(9):4573-82. PMID: 20660060.
    Citations: 31     Fields:    Translation:AnimalsCells
  72. Castillo M, Freitas BC, Rosene ML, Drigo RA, Grozovsky R, Maciel RM, Patti ME, Ribeiro MO, Bianco AC. Impaired metabolic effects of a thyroid hormone receptor beta-selective agonist in a mouse model of diet-induced obesity. Thyroid. 2010 May; 20(5):545-53. PMID: 20406106; PMCID: PMC2941403.
    Citations: 9     Fields:    Translation:AnimalsCells
  73. Zelezniak A, Pers TH, Soares S, Patti ME, Patil KR. Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes. PLoS Comput Biol. 2010 Apr 01; 6(4):e1000729. PMID: 20369014; PMCID: PMC2848542.
    Citations: 35     Fields:    Translation:HumansCells
  74. Halperin F, Patti ME, Goldfine AB. Glucagon treatment for post-gastric bypass hypoglycemia. Obesity (Silver Spring). 2010 Sep; 18(9):1858-60. PMID: 20168313; PMCID: PMC4465911.
    Citations: 3     Fields:    Translation:Humans
  75. Patti ME, Corvera S. The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev. 2010 Jun; 31(3):364-95. PMID: 20156986; PMCID: PMC3365846.
    Citations: 133     Fields:    Translation:HumansAnimalsCells
  76. Espinoza DO, Boros LG, Crunkhorn S, Gami H, Patti ME. Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes. FASEB J. 2010 Apr; 24(4):1003-14. PMID: 19906680; PMCID: PMC2845426.
    Citations: 23     Fields:    Translation:AnimalsCells
  77. Pihlajamäki J, Boes T, Kim EY, Dearie F, Kim BW, Schroeder J, Mun E, Nasser I, Park PJ, Bianco AC, Goldfine AB, Patti ME. Thyroid hormone-related regulation of gene expression in human fatty liver. J Clin Endocrinol Metab. 2009 Sep; 94(9):3521-9. PMID: 19549744; PMCID: PMC2741713.
    Citations: 44     Fields:    Translation:HumansAnimals
  78. Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 2009 May; 9(5):428-39. PMID: 19416713.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  79. Patti ME, Houten SM, Bianco AC, Bernier R, Larsen PR, Holst JJ, Badman MK, Maratos-Flier E, Mun EC, Pihlajamaki J, Auwerx J, Goldfine AB. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring). 2009 Sep; 17(9):1671-7. PMID: 19360006.
    Citations: 181     Fields:    Translation:HumansCells
  80. Sutherland AP, Zhang H, Zhang Y, Michaud M, Xie Z, Patti ME, Grusby MJ, Zhang WJ. Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis. Mol Cell Biol. 2009 May; 29(10):2804-15. PMID: 19273596; PMCID: PMC2682054.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  81. Apovian CM, Cummings S, Anderson W, Borud L, Boyer K, Day K, Hatchigian E, Hodges B, Patti ME, Pettus M, Perna F, Rooks D, Saltzman E, Skoropowski J, Tantillo MB, Thomason P. Best practice updates for multidisciplinary care in weight loss surgery. Obesity (Silver Spring). 2009 May; 17(5):871-9. PMID: 19396065; PMCID: PMC2859198.
    Citations: 18     Fields:    Translation:Humans
  82. Isganaitis E, Jimenez-Chillaron J, Woo M, Chow A, DeCoste J, Vokes M, Liu M, Kasif S, Zavacki AM, Leshan RL, Myers MG, Patti ME. Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice. Diabetes. 2009 May; 58(5):1192-200. PMID: 19208909; PMCID: PMC2671035.
    Citations: 29     Fields:    Translation:AnimalsCells
  83. Jin W, Patti ME. Genetic determinants and molecular pathways in the pathogenesis of Type 2 diabetes. Clin Sci (Lond). 2009 Jan; 116(2):99-111. PMID: 19076063.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  84. Grozovsky R, Ribich S, Rosene ML, Mulcahey MA, Huang SA, Patti ME, Bianco AC, Kim BW. Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. Endocrinology. 2009 Apr; 150(4):1976-83. PMID: 19036883; PMCID: PMC2659265.
    Citations: 29     Fields:    Translation:AnimalsCells
  85. Jimenez-Chillaron JC, Isganaitis E, Charalambous M, Gesta S, Pentinat-Pelegrin T, Faucette RR, Otis JP, Chow A, Diaz R, Ferguson-Smith A, Patti ME. Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Diabetes. 2009 Feb; 58(2):460-8. PMID: 19017762; PMCID: PMC2628621.
    Citations: 82     Fields:    Translation:Animals
  86. Doria A, Patti ME, Kahn CR. The emerging genetic architecture of type 2 diabetes. Cell Metab. 2008 Sep; 8(3):186-200. PMID: 18762020; PMCID: PMC4267677.
    Citations: 99     Fields:    Translation:HumansAnimals
  87. Ruddock MW, Stein A, Landaker E, Park J, Cooksey RC, McClain D, Patti ME. Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. J Biochem. 2008 Nov; 144(5):599-607. PMID: 18713797.
    Citations: 20     Fields:    Translation:AnimalsCells
  88. Isshiki K, He Z, Maeno Y, Ma RC, Yasuda Y, Kuroki T, White GS, Patti ME, Weir GC, King GL. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int. 2008 Dec; 74(11):1434-43. PMID: 19008912; PMCID: PMC2644821.
    Citations: 4     Fields:    Translation:AnimalsCells
  89. Woo M, Patti ME. Diabetes risk begins in utero. Cell Metab. 2008 Jul; 8(1):5-7. PMID: 18590686.
    Citations: 12     Fields:    Translation:Humans
  90. Crunkhorn S, Patti ME. Links between thyroid hormone action, oxidative metabolism, and diabetes risk? Thyroid. 2008 Feb; 18(2):227-37. PMID: 18279023.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  91. Goldfine AB, Mun EC, Devine E, Bernier R, Baz-Hecht M, Jones DB, Schneider BE, Holst JJ, Patti ME. Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J Clin Endocrinol Metab. 2007 Dec; 92(12):4678-85. PMID: 17895322.
    Citations: 93     Fields:    Translation:Humans
  92. Crunkhorn S, Dearie F, Mantzoros C, Gami H, da Silva WS, Espinoza D, Faucette R, Barry K, Bianco AC, Patti ME. Peroxisome proliferator activator receptor gamma coactivator-1 expression is reduced in obesity: potential pathogenic role of saturated fatty acids and p38 mitogen-activated protein kinase activation. J Biol Chem. 2007 May 25; 282(21):15439-50. PMID: 17416903.
    Citations: 76     Fields:    Translation:AnimalsCells
  93. Oge A, Isganaitis E, Jimenez-Chillaron J, Reamer C, Faucette R, Barry K, Przybyla R, Patti ME. In utero undernutrition reduces diabetes incidence in non-obese diabetic mice. Diabetologia. 2007 May; 50(5):1099-108. PMID: 17370059.
    Citations: 6     Fields:    Translation:Animals
  94. Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GL. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20. PMID: 17363743.
    Citations: 24     Fields:    Translation:AnimalsCells
  95. Jimenez-Chillaron JC, Patti ME. To catch up or not to catch up: is this the question? Lessons from animal models. Curr Opin Endocrinol Diabetes Obes. 2007 Feb; 14(1):23-9. PMID: 17940415.
    Citations: 17     Fields:    Translation:Animals
  96. Hernandez-Valencia M, Patti ME. A thin phenotype is protective for impaired glucose tolerance and related to low birth weight in mice. Arch Med Res. 2006 Oct; 37(7):813-7. PMID: 16971218.
    Citations: 2     Fields:    Translation:Animals
  97. Jimenez-Chillaron JC, Hernandez-Valencia M, Lightner A, Faucette RR, Reamer C, Przybyla R, Ruest S, Barry K, Otis JP, Patti ME. Reductions in caloric intake and early postnatal growth prevent glucose intolerance and obesity associated with low birthweight. Diabetologia. 2006 Aug; 49(8):1974-84. PMID: 16761107.
    Citations: 40     Fields:    Translation:Humans
  98. Tiffin N, Adie E, Turner F, Brunner HG, van Driel MA, Oti M, Lopez-Bigas N, Ouzounis C, Perez-Iratxeta C, Andrade-Navarro MA, Adeyemo A, Patti ME, Semple CA, Hide W. Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes. Nucleic Acids Res. 2006; 34(10):3067-81. PMID: 16757574; PMCID: PMC1475747.
    Citations: 57     Fields:    Translation:Humans
  99. Goldfine AB, Beckman JA, Betensky RA, Devlin H, Hurley S, Varo N, Schonbeck U, Patti ME, Creager MA. Family history of diabetes is a major determinant of endothelial function. J Am Coll Cardiol. 2006 Jun 20; 47(12):2456-61. PMID: 16781373.
    Citations: 18     Fields:    Translation:Humans
  100. Ilany J, Bilan PJ, Kapur S, Caldwell JS, Patti ME, Marette A, Kahn CR. Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4481-6. PMID: 16537411; PMCID: PMC1450197.
    Citations: 10     Fields:    Translation:AnimalsCells
  101. Goldfine AB, Crunkhorn S, Costello M, Gami H, Landaker EJ, Niinobe M, Yoshikawa K, Lo D, Warren A, Jimenez-Chillaron J, Patti ME. Necdin and E2F4 are modulated by rosiglitazone therapy in diabetic human adipose and muscle tissue. Diabetes. 2006 Mar; 55(3):640-50. PMID: 16505226.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  102. Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN. Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. Am J Physiol Endocrinol Metab. 2006 Jun; 290(6):E1296-303. PMID: 16434556.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  103. Myers MG, Patti ME, Leshan RL. Hitting the target: leptin and perinatal nutrition in the predisposition to obesity. Endocrinology. 2005 Oct; 146(10):4209-10. PMID: 16166232.
    Citations: 4     Fields:    Translation:HumansAnimals
  104. Patti ME, McMahon G, Mun EC, Bitton A, Holst JJ, Goldsmith J, Hanto DW, Callery M, Arky R, Nose V, Bonner-Weir S, Goldfine AB. Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia. Diabetologia. 2005 Nov; 48(11):2236-40. PMID: 16195867.
    Citations: 89     Fields:    Translation:Humans
  105. Halperin F, Beckman JA, Patti ME, Trujillo ME, Garvin M, Creager MA, Scherer PE, Goldfine AB. The role of total and high-molecular-weight complex of adiponectin in vascular function in offspring whose parents both had type 2 diabetes. Diabetologia. 2005 Oct; 48(10):2147-54. PMID: 16091909.
    Citations: 8     Fields:    Translation:Humans
  106. Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005 Jun; 7(6):601-11. PMID: 15895078.
    Citations: 70     Fields:    Translation:AnimalsCells
  107. Jimenez-Chillaron JC, Hernandez-Valencia M, Reamer C, Fisher S, Joszi A, Hirshman M, Oge A, Walrond S, Przybyla R, Boozer C, Goodyear LJ, Patti ME. Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model. Diabetes. 2005 Mar; 54(3):702-11. PMID: 15734846.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  108. Gordon LB, Harten IA, Patti ME, Lichtenstein AH. Reduced adiponectin and HDL cholesterol without elevated C-reactive protein: clues to the biology of premature atherosclerosis in Hutchinson-Gilford Progeria Syndrome. J Pediatr. 2005 Mar; 146(3):336-41. PMID: 15756215.
    Citations: 14     Fields:    Translation:Humans
  109. Yechoor VK, Patti ME, Ueki K, Laustsen PG, Saccone R, Rauniyar R, Kahn CR. Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16525-30. PMID: 15546994; PMCID: PMC534529.
    Citations: 34     Fields:    Translation:AnimalsCells
  110. Patti ME, Kahn BB. Nutrient sensor links obesity with diabetes risk. Nat Med. 2004 Oct; 10(10):1049-50. PMID: 15459705.
    Citations: 17     Fields:    Translation:AnimalsCells
  111. Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJ, Shankhdhar K, Shankhdhar L, Shankhdhar U, Petrova NL, Foster AV, Edmonds ME, Ferraresi R, Caravaggi C, De Giglio R, Cavaiani P, Pogliaghi I, Sommariva E, Katz IA, Harlan A, Miranda-Palma B, Prieto-Sanchez L, Armstrong DG, Bowker JH, Mizel MS, Cernea S, Wohlgelernter J, Kidron M, Modi P, Raz I, Arbit E, Nosek L, Kapitza C, Beckett P, Gelfand R, Goldberg M, Heise T, Testa MA, Turner RR, Hayes JF, Scranton RE, Simonson DC, Yang YW, Hsu YJ, Naujok O, Francini F, Jörns A, Tiedge M, Lenzen S, Abdel-Wahab YH, Marenah L, Orr DF, Shaw C, Flatt PR, Chokkalingam K, Mansell PI, Clausen P, Ekbom P, Damm P, Feldt-Rasmussen U, Nielsen B, Mathiesen ER, Feldt-Rasmussen B, Dewan S, Da Silva N, Ternan PM, Leong KS, Wilding JP, Asatiani N, Kurashvili R, Dundua M, Shelestova E, Pagava K, Ramazashvili M, Hod M, Smirnov S, Petersen JL, Justesen TI, Ringholm Nielsen L, Müller C, Højlund K, Wensaas A, Kase ET, Aas V, Rustan AC, Thoresen GH, Levin K, Beck-Nielsen H, Gaster M, Im SS, Kang SY, Kim SY, Ahn YH, Lihn AS, Schmoll D, Werner T, Kienitz A, Meyer M, Barthel A, Ailett F, Sutherland C, Walther R, Grempler R, Sasson S, Reich R, Tenenbaum T, Alpert E, Anfossi G, Russo I, Traversa M, Massucco P, Mattiello L, Doronzo G, Trovati M, Lally S, Tan CY, Owens D, Tomkin GH, Porchay I, Péan F, Bellili N, Betoulle D, Balkau B, Tichet J, Marre M, Fumeron F, Chatellier G, Alhenc-Gelas F, Nichols GA, Brown JB, Hayes RP, Bowman L, Drexel H, Saely CH, Marte T, Benzer W, Langer P, Hoefle G, Moll W, Aczel S, Karagiannis E, Lübben G, Urquhart R, Edwards G, Bruce S, Howlett HS, Cugnardey N, Turner KC, Park JS, Fiedorek FT, Avogaro A, Gallo A, Pinton P, Rizzuto R, Murphy E, Ceolotto G, Caterson I, Guy-Grand B, Hill J, Barone M, Aiello A, Allochis G, Borzì V, Cannatà F, Caronna S, D'Avanzo A, Elli R, Formoso G, Paroli A, Scardapane R, Sorichetti P, Tatti P, Viviani G, Santeusanio F, Manzella D, Grella R, Abbatecola AM, Paolisso G, Søndergaard LG, Monster TB, Johnsen SP, Olsen ML, McLaughlin JK, Sørensen HT, Lervang HH, Rungby J, Lyssenko V, Fredriksson J, Almgren P, Anevski D, Orho-Melander M, Sjögren M, Tuomi T, Groop L, Jaziri R, Aubert R, Tuomilehto J, Hu G, Jousilahti P, Peltonen M, Lindstrom J, Laina A, Alevizaki M, Philippou G, Souvatzoglou A, Anastasiou E, Alba S, Metcalf BS, Voss LD, Jeffery AN, Wilkin TJ, Glüimer C, Colagiuri S, Vistisen D, Borch-Johnsen K, Haynes A, Bower C, Bulsara MK, Jones TW, Davis EA, Mortensen HB, Hougaard P, Holl R, Swift P, Pociot F, Knip M, Hansen L, Szadkowska A, Pietrzak I, Zmyslowska A, Wyka K, Bodalski J, Holl RW, Swift R, Hougaard R, Gerstl EM, Engelsberger I, Rabl W, Rosenbauer J, Gröbe H, Hofer SE, Krause U, Dabelea D, Morgan T, Pettitt DJ, Dolan L, Mayer-Davis EJ, Pihoker C, Hillier TA, Imperatore G, Ruggiero A, Hamman RE, Stylianou A, Tentolouris N, Perrea D, Tselepis AD, Lourida E, Kitsou E, Katsilambros N, Vedovato M, Dodesini AR, Lepore G, Tiengo A, Trevisan R, Penno G, Miccoli R, Pucci L, Lucchesi D, Bandinelli S, Fotino C, Triscornia S, Baldassari E, Del Prato S, Reboldi P, Santeusanio E, Fuller J, Langham RG, Gow RM, Zhang Y, Kelly DJ, Christensen PK, Parving HH, Gilbert RE, Chibalin AV, Zhong Z, Kotova O, Davidescu A, Ehrén I, Ekberg K, Wahren J, Wassef L, Buckley AJ, Rooney KB, Briody J, Thompson M, Ozanne SE, Thompson CH, Chamson-Reig A, Summers K, Arany EJ, Hill DJ, Solerte SB, Gazzaruso C, Locatelli E, Precerutti S, Schifino N, Ferrari E, Fioravanti M, Phenekos CV, Ginis A, Fragaki I, Chalkiadaki M, Tzioras C, Powell LA, McGuire GM, Jewhurst V, Trimble ER, Rasmussen BM, Vessby B, Uusitupa M, Berglund L, Pedersen E, Riccardi G, Rivellese AA, Tapsell L, Hermansen K, da Silva Xavier G, Rutter J, Rutter GA, Briaud IM, Lingohr MK, Dickson LM, McCuaig JR, Lawrence JC, Rhodes CJ, Wikstrom JD, Katzman SM, Shirihai OS, Yang J, Deng S, Wang X, Hessner MJ, Wu J, Wong RK, et al. 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia. 2004 Aug; 47(Suppl 1):A1-A464. PMID: 27770180.
    Citations: 2     Fields:    
  112. Patti ME. Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology? Curr Opin Clin Nutr Metab Care. 2004 Jul; 7(4):383-90. PMID: 15192439.
    Citations: 9     Fields:    Translation:Humans
  113. Patti ME. Gene expression in the pathophysiology of type 2 diabetes mellitus. Curr Diab Rep. 2004 Jun; 4(3):176-81. PMID: 15132881.
    Citations: 3     Fields:    Translation:HumansAnimals
  114. Blüher M, Patti ME, Gesta S, Kahn BB, Kahn CR. Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression. J Biol Chem. 2004 Jul 23; 279(30):31891-901. PMID: 15131119.
    Citations: 26     Fields:    Translation:AnimalsCells
  115. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8466-71. PMID: 12832613; PMCID: PMC166252.
    Citations: 597     Fields:    Translation:HumansCells
  116. Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC, Patti ME, Klein SL, Weinstein RS, Scherer PE. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes. 2003 Feb; 52(2):268-76. PMID: 12540596.
    Citations: 107     Fields:    Translation:AnimalsCells
  117. Yechoor VK, Patti ME, Saccone R, Kahn CR. Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10587-92. PMID: 12149437.
    Citations: 32     Fields:    Translation:AnimalsCells
  118. Fraenkel PG, Rutkove SB, Matheson JK, Fowkes M, Cannon ME, Patti ME, Atkins MB, Gollob JA. Induction of myasthenia gravis, myositis, and insulin-dependent diabetes mellitus by high-dose interleukin-2 in a patient with renal cell cancer. J Immunother. 2002 Jul-Aug; 25(4):373-8. PMID: 12142560.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  119. Orban T, Landaker E, Ruan Z, Cordeman TP, Weitgasser R, Bonner-Weir S, Jackson RA, Patti ME. High-fructose diet preserves beta-cell mass and prevents diabetes in nonobese diabetic mice: A potential role for increased insulin receptor substrate-2 expression. Metabolism. 2001 Nov; 50(11):1369-76. PMID: 11699059.
    Citations:    Fields:    Translation:Animals
  120. Rosas HD, Goodman J, Chen YI, Jenkins BG, Kennedy DN, Makris N, Patti M, Seidman LJ, Beal MF, Koroshetz WJ. Striatal volume loss in HD as measured by MRI and the influence of CAG repeat. Neurology. 2001 Sep 25; 57(6):1025-8. PMID: 11571328.
    Citations: 44     Fields:    Translation:HumansCells
  121. Goldfine AB, Patti ME, Zuberi L, Goldstein BJ, LeBlanc R, Landaker EJ, Jiang ZY, Willsky GR, Kahn CR. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism. 2000 Mar; 49(3):400-10. PMID: 10726921.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  122. Cusi K, Maezono K, Osman A, Pendergrass M, Patti ME, Pratipanawatr T, DeFronzo RA, Kahn CR, Mandarino LJ. Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest. 2000 Feb; 105(3):311-20. PMID: 10675357; PMCID: PMC377440.
    Citations: 217     Fields:    Translation:HumansCells
  123. Patti ME. Nutrient modulation of cellular insulin action. Ann N Y Acad Sci. 1999 Nov 18; 892:187-203. PMID: 10842663.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  124. Patti ME, Virkamäki A, Landaker EJ, Kahn CR, Yki-Järvinen H. Activation of the hexosamine pathway by glucosamine in vivo induces insulin resistance of early postreceptor insulin signaling events in skeletal muscle. Diabetes. 1999 Aug; 48(8):1562-71. PMID: 10426374.
    Citations: 46     Fields:    Translation:AnimalsCells
  125. Koval JA, Maezono K, Patti ME, Pendergrass M, DeFronzo RA, Mandarino LJ. Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle. Med Sci Sports Exerc. 1999 Jul; 31(7):998-1004. PMID: 10416561.
    Citations: 11     Fields:    Translation:HumansCells
  126. Patti ME, Brambilla E, Luzi L, Landaker EJ, Kahn CR. Bidirectional modulation of insulin action by amino acids. J Clin Invest. 1998 Apr 01; 101(7):1519-29. PMID: 9525995.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  127. Patti ME, Kahn CR. The insulin receptor--a critical link in glucose homeostasis and insulin action. J Basic Clin Physiol Pharmacol. 1998; 9(2-4):89-109. PMID: 10212828.
    Citations: 14     Fields:    Translation:HumansAnimals
  128. Smith-Hall J, Pons S, Patti ME, Burks DJ, Yenush L, Sun XJ, Kahn CR, White MF. The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells. Biochemistry. 1997 Jul 08; 36(27):8304-10. PMID: 9204876.
    Citations: 16     Fields:    Translation:AnimalsCells
  129. Patti ME, Kahn CR. Lessons from transgenic and knockout animals about noninsulin-dependent diabetes mellitus. Trends Endocrinol Metab. 1996 Nov; 7(9):311-9. PMID: 18406764.
    Citations: 3     Fields:    
  130. Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR. In vivo and in vitro studies of vanadate in human and rodent diabetes mellitus. Mol Cell Biochem. 1995 Dec 6-20; 153(1-2):217-31. PMID: 8927042.
    Citations: 23     Fields:    Translation:HumansAnimals
  131. Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab. 1995 Nov; 80(11):3311-20. PMID: 7593444.
    Citations: 24     Fields:    Translation:HumansCTClinical Trials
  132. Patti ME, Sun XJ, Bruening JC, Araki E, Lipes MA, White MF, Kahn CR. 4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem. 1995 Oct 20; 270(42):24670-3. PMID: 7559579.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  133. Araki E, Lipes MA, Patti ME, Brüning JC, Haag B, Johnson RS, Kahn CR. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature. 1994 Nov 10; 372(6502):186-90. PMID: 7526222.
    Citations: 270     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.