Harvard Catalyst Profiles

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Barak Caine, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R29DA012142 (CAINE, SIMON BARAK) Mar 12, 1999 - Feb 28, 2005
    Role: Principal Investigator
  2. F31DA005478 (CAINE, SIMON BARAK) Mar 31, 1992
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Thomsen M, Barrett AC, Butler P, Negus SS, Caine SB. Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats. J Pharmacol Exp Ther. 2017 07; 362(1):161-176. PMID: 28473458.
    Citations: 8     Fields:    Translation:Animals
  2. Sørensen G, Caine SB, Thomsen M. Effects of the GLP-1 Agonist Exendin-4 on Intravenous Ethanol Self-Administration in Mice. Alcohol Clin Exp Res. 2016 10; 40(10):2247-2252. PMID: 27579999.
    Citations: 9     Fields:    Translation:Animals
  3. Thomsen M, Caine SB. Effects of dopamine D1-like and D2-like antagonists on cocaine discrimination in muscarinic receptor knockout mice. Eur J Pharmacol. 2016 Apr 05; 776:71-80. PMID: 26874213.
    Citations:    Fields:    Translation:Animals
  4. Mello NK, Fivel PA, Kohut SJ, Caine SB. Anatabine significantly decreases nicotine self-administration. Exp Clin Psychopharmacol. 2014 Feb; 22(1):1-8. PMID: 24490707.
    Citations: 6     Fields:    Translation:Animals
  5. Thomsen M, Fulton BS, Caine SB. Acute and chronic effects of the M1/M4-preferring muscarinic agonist xanomeline on cocaine vs. food choice in rats. Psychopharmacology (Berl). 2014 Feb; 231(3):469-79. PMID: 23995301.
    Citations: 11     Fields:    Translation:Animals
  6. Thomsen M, Barrett AC, Negus SS, Caine SB. Cocaine versus food choice procedure in rats: environmental manipulations and effects of amphetamine. J Exp Anal Behav. 2013 Mar; 99(2):211-33. PMID: 23319458.
    Citations: 52     Fields:    Translation:Animals
  7. Caine SB, Thomsen M, Barrett AC, Collins GT, Grundt P, Newman AH, Butler P, Xu M. Cocaine self-administration in dopamine D3 receptor knockout mice. Exp Clin Psychopharmacol. 2012 Oct; 20(5):352-63. PMID: 22867038.
    Citations: 16     Fields:    Translation:Animals
  8. Collins GT, Butler P, Wayman C, Ratcliffe S, Gupta P, Oberhofer G, Caine SB. Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats. Behav Pharmacol. 2012 Jun; 23(3):280-91. PMID: 22470105.
    Citations: 6     Fields:    Translation:Animals
  9. Thomsen M, Lindsley CW, Conn PJ, Wessell JE, Fulton BS, Wess J, Caine SB. Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice. Psychopharmacology (Berl). 2012 Apr; 220(4):673-85. PMID: 21964721.
    Citations: 14     Fields:    Translation:Animals
  10. Thomsen M, Caine SB. Psychomotor stimulant effects of cocaine in rats and 15 mouse strains. Exp Clin Psychopharmacol. 2011 Oct; 19(5):321-41. PMID: 21843010.
    Citations: 32     Fields:    Translation:Animals
  11. Thomsen M, Ralph RJ, Caine SB. Psychomotor stimulation by dopamine D1-like but not D2-like agonists in most mouse strains. Exp Clin Psychopharmacol. 2011 Oct; 19(5):342-60. PMID: 21843011.
    Citations: 5     Fields:    Translation:Animals
  12. Thomsen M, Caine SB. False positive in the intravenous drug self-administration test in C57BL/6J mice. Behav Pharmacol. 2011 Jun; 22(3):239-47. PMID: 21522054.
    Citations: 13     Fields:    Translation:Animals
  13. Lin Z, Canales JJ, Björgvinsson T, Thomsen M, Qu H, Liu QR, Torres GE, Caine SB. Monoamine transporters: vulnerable and vital doorkeepers. Prog Mol Biol Transl Sci. 2011; 98:1-46. PMID: 21199769.
    Citations: 21     Fields:    Translation:HumansAnimals
  14. Thomsen M, Wess J, Fulton BS, Fink-Jensen A, Caine SB. Modulation of prepulse inhibition through both M(1) and M (4) muscarinic receptors in mice. Psychopharmacology (Berl). 2010 Feb; 208(3):401-16. PMID: 20013114.
    Citations: 16     Fields:    Translation:Animals
  15. Thomsen M, Conn PJ, Lindsley C, Wess J, Boon JY, Fulton BS, Fink-Jensen A, Caine SB. Attenuation of cocaine's reinforcing and discriminative stimulus effects via muscarinic M1 acetylcholine receptor stimulation. J Pharmacol Exp Ther. 2010 Mar; 332(3):959-69. PMID: 19996296.
    Citations: 19     Fields:    Translation:AnimalsCells
  16. Thomsen M, Han DD, Gu HH, Caine SB. Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. J Pharmacol Exp Ther. 2009 Oct; 331(1):204-11. PMID: 19602552.
    Citations: 53     Fields:    Translation:Animals
  17. Thomsen M, Hall FS, Uhl GR, Caine SB. Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. J Neurosci. 2009 Jan 28; 29(4):1087-92. PMID: 19176817.
    Citations: 56     Fields:    Translation:Animals
  18. Thomsen M, Fink-Jensen A, Woldbye DP, Wörtwein G, Sager TN, Holm R, Pepe LM, Caine SB. Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats. Psychopharmacology (Berl). 2008 Nov; 201(1):43-53. PMID: 18612628.
    Citations: 35     Fields:    Translation:Animals
  19. Caine SB, Thomsen M, Gabriel KI, Berkowitz JS, Gold LH, Koob GF, Tonegawa S, Zhang J, Xu M. Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci. 2007 Nov 28; 27(48):13140-50. PMID: 18045908.
    Citations: 84     Fields:    Translation:Animals
  20. Thomsen M, Wörtwein G, Fink-Jensen A, Woldbye DP, Wess J, Caine SB. Decreased prepulse inhibition and increased sensitivity to muscarinic, but not dopaminergic drugs in M5 muscarinic acetylcholine receptor knockout mice. Psychopharmacology (Berl). 2007 May; 192(1):97-110. PMID: 17310388.
    Citations: 20     Fields:    Translation:Animals
  21. Ralph RJ, Caine SB. Effects of selective dopamine D1-like and D2-like agonists on prepulse inhibition of startle in inbred C3H/HeJ, SPRET/EiJ, and CAST/EiJ mice. Psychopharmacology (Berl). 2007 Apr; 191(3):731-9. PMID: 17019570.
    Citations: 10     Fields:    Translation:Animals
  22. Thomsen M, Caine SB. Intravenous drug self-administration in mice: practical considerations. Behav Genet. 2007 Jan; 37(1):101-18. PMID: 17226102.
    Citations: 38     Fields:    Translation:HumansAnimals
  23. Thomsen M, Caine SB. Cocaine self-administration under fixed and progressive ratio schedules of reinforcement: comparison of C57BL/6J, 129X1/SvJ, and 129S6/SvEvTac inbred mice. Psychopharmacology (Berl). 2006 Jan; 184(2):145-54. PMID: 16369835.
    Citations: 23     Fields:    Translation:Animals
  24. Thomsen M, Woldbye DP, Wörtwein G, Fink-Jensen A, Wess J, Caine SB. Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice. J Neurosci. 2005 Sep 07; 25(36):8141-9. PMID: 16148222.
    Citations: 54     Fields:    Translation:Animals
  25. Thomsen M, Caine SB. Chronic intravenous drug self-administration in rats and mice. Curr Protoc Neurosci. 2005 Aug; Chapter 9:Unit 9.20. PMID: 18428629.
    Citations: 54     Fields:    Translation:Animals
  26. Barrett AC, Negus SS, Mello NK, Caine SB. Effect of GABA agonists and GABA-A receptor modulators on cocaine- and food-maintained responding and cocaine discrimination in rats. J Pharmacol Exp Ther. 2005 Nov; 315(2):858-71. PMID: 16033912.
    Citations: 25     Fields:    Translation:Animals
  27. Ralph RJ, Caine SB. Dopamine D1 and D2 agonist effects on prepulse inhibition and locomotion: comparison of Sprague-Dawley rats to Swiss-Webster, 129X1/SvJ, C57BL/6J, and DBA/2J mice. J Pharmacol Exp Ther. 2005 Feb; 312(2):733-41. PMID: 15494551.
    Citations: 56     Fields:    Translation:Animals
  28. Tsai G, Ralph-Williams RJ, Martina M, Bergeron R, Berger-Sweeney J, Dunham KS, Jiang Z, Caine SB, Coyle JT. Gene knockout of glycine transporter 1: characterization of the behavioral phenotype. Proc Natl Acad Sci U S A. 2004 Jun 01; 101(22):8485-90. PMID: 15159536.
    Citations: 56     Fields:    Translation:AnimalsCells
  29. Caine SB, Bowen CA, Yu G, Zuzga D, Negus SS, Mello NK. Effect of gonadectomy and gonadal hormone replacement on cocaine self-administration in female and male rats. Neuropsychopharmacology. 2004 May; 29(5):929-42. PMID: 14735136.
    Citations: 46     Fields:    Translation:Animals
  30. Barrett AC, Miller JR, Dohrmann JM, Caine SB. Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats. Neuropharmacology. 2004; 47 Suppl 1:256-73. PMID: 15464142.
    Citations: 62     Fields:    Translation:Animals
  31. Caine SB, Ralph-Williams RJ. Behavioral pharmacologists: don't just say "no" to knockout mice. Commentary on Stephens et al. 'Studying the neurobiology of stimulant and alcohol abuse and dependence in genetically manipulated mice'. Behav Pharmacol. 2002 Sep; 13(5-6):349-52. PMID: 12394409.
    Citations: 1     Fields:    Translation:Animals
  32. Caine SB, Negus SS, Mello NK, Patel S, Bristow L, Kulagowski J, Vallone D, Saiardi A, Borrelli E. Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists. J Neurosci. 2002 Apr 01; 22(7):2977-88. PMID: 11923462.
    Citations: 93     Fields:    Translation:Animals
  33. Caine SB, Negus SS, Mello NK, Bergman J. Effects of dopamine D1-like and D2-like agonists in rats trained to discriminate cocaine from saline: influence of experimental history. Exp Clin Psychopharmacol. 2000 Aug; 8(3):404-14. PMID: 10975632.
    Citations: 11     Fields:    Translation:Animals
  34. Caine SB, Negus SS, Mello NK. Effects of dopamine D(1-like) and D(2-like) agonists on cocaine self-administration in rhesus monkeys: rapid assessment of cocaine dose-effect functions. Psychopharmacology (Berl). 2000 Jan; 148(1):41-51. PMID: 10663416.
    Citations: 23     Fields:    Translation:Animals
  35. Caine SB, Negus SS, Mello NK. Method for training operant responding and evaluating cocaine self-administration behavior in mutant mice. Psychopharmacology (Berl). 1999 Nov; 147(1):22-4. PMID: 10591861.
    Citations: 34     Fields:    Translation:Animals
  36. Caine SB, Negus SS, Mello NK, Bergman J. Effects of dopamine D(1-like) and D(2-like) agonists in rats that self-administer cocaine. J Pharmacol Exp Ther. 1999 Oct; 291(1):353-60. PMID: 10490924.
    Citations: 53     Fields:    Translation:Animals
  37. Koob GF, Caine SB. Cocaine addiction therapy--are we partially there? Nat Med. 1999 Sep; 5(9):993-5. PMID: 10470073.
    Citations: 3     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.