Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Demetrios Vavvas, M.D.,Ph.D.

Co-Author

This page shows the publications co-authored by Demetrios Vavvas and Joan Miller.
Connection Strength

12.177
  1. Age-Related Macular Degeneration (AMD): A View to the Future. J Clin Med. 2021 Mar 08; 10(5).
    View in: PubMed
    Score: 0.958
  2. Advances in Age-related Macular Degeneration Understanding and Therapy. US Ophthalmic Rev. 2017; 10(2):119-130.
    View in: PubMed
    Score: 0.717
  3. Regression of Some High-risk Features of Age-related Macular Degeneration (AMD) in Patients Receiving Intensive Statin Treatment. EBioMedicine. 2016 Mar; 5:198-203.
    View in: PubMed
    Score: 0.673
  4. Local photoreceptor cell death differences in the murine model of retinal detachment. Sci Rep. 2021 Sep 22; 11(1):18798.
    View in: PubMed
    Score: 0.249
  5. Complement Inhibition for Geographic Atrophy: A Tempting Target with Mixed Results. J Clin Med. 2021 Jun 29; 10(13).
    View in: PubMed
    Score: 0.245
  6. A Review of Completed and Ongoing Complement Inhibitor Trials for Geographic Atrophy Secondary to Age-Related Macular Degeneration. J Clin Med. 2021 Jun 11; 10(12).
    View in: PubMed
    Score: 0.244
  7. Reply. Ophthalmol Retina. 2021 03; 5(3):e4.
    View in: PubMed
    Score: 0.239
  8. Acadesine suppresses TNF-a induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells. PLoS One. 2020; 15(12):e0244307.
    View in: PubMed
    Score: 0.236
  9. ThicknessTool: automated ImageJ retinal layer thickness and profile in digital images. Sci Rep. 2020 10 28; 10(1):18459.
    View in: PubMed
    Score: 0.234
  10. Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23724-23734.
    View in: PubMed
    Score: 0.218
  11. RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization. Proc Natl Acad Sci U S A. 2019 11 19; 116(47):23705-23713.
    View in: PubMed
    Score: 0.218
  12. Percentage of Foveal vs Total Macular Geographic Atrophy as a Predictor of Visual Acuity in Age-Related Macular Degeneration. J Vitreoretin Dis. 2019 Sep; 3(5):278-282.
    View in: PubMed
    Score: 0.215
  13. NLRP3 inflammasome in NMDA-induced retinal excitotoxicity. Exp Eye Res. 2019 04; 181:136-144.
    View in: PubMed
    Score: 0.207
  14. Receptor interacting protein kinase 3 (RIP3) regulates iPSCs generation through modulating cell cycle progression genes. Stem Cell Res. 2019 03; 35:101387.
    View in: PubMed
    Score: 0.207
  15. Lens regeneration in children. Nature. 2018 04 04; 556(7699):E2-E3.
    View in: PubMed
    Score: 0.196
  16. Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Sci Rep. 2018 01 11; 8(1):461.
    View in: PubMed
    Score: 0.193
  17. AICAR suppresses TNF-a-induced complement factor B in RPE cells. Sci Rep. 2017 12 15; 7(1):17651.
    View in: PubMed
    Score: 0.192
  18. Verteporfin inhibits growth of human glioma in vitro without light activation. Sci Rep. 2017 08 08; 7(1):7602.
    View in: PubMed
    Score: 0.187
  19. Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells. Sci Rep. 2017 05 24; 7(1):2329.
    View in: PubMed
    Score: 0.184
  20. Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity. Sci Rep. 2017 04 21; 7:46581.
    View in: PubMed
    Score: 0.183
  21. AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-?B Pathway in RAW264.7 Macrophages. PLoS One. 2016; 11(1):e0147279.
    View in: PubMed
    Score: 0.168
  22. Drug Delivery Nanoparticles: Toxicity Comparison in Retinal Pigment Epithelium and Retinal Vascular Endothelial Cells. Semin Ophthalmol. 2016; 31(1-2):1-9.
    View in: PubMed
    Score: 0.167
  23. A Novel ImageJ Macro for Automated Cell Death Quantitation in the Retina. Invest Ophthalmol Vis Sci. 2015 Oct; 56(11):6701-8.
    View in: PubMed
    Score: 0.164
  24. Mitochondrial DNA has a pro-inflammatory role in AMD. Biochim Biophys Acta. 2015 Nov; 1853(11 Pt A):2897-906.
    View in: PubMed
    Score: 0.163
  25. Effects of metformin on retinoblastoma growth in vitro and in vivo. Int J Oncol. 2014 Dec; 45(6):2311-24.
    View in: PubMed
    Score: 0.153
  26. Cholesterol crystals induce inflammatory cytokines expression in a human retinal pigment epithelium cell line by activating the NF-?B pathway. Discov Med. 2014 Jul-Aug; 18(97):7-14.
    View in: PubMed
    Score: 0.151
  27. Strain difference in photoreceptor cell death after retinal detachment in mice. Invest Ophthalmol Vis Sci. 2014 May 22; 55(7):4165-74.
    View in: PubMed
    Score: 0.150
  28. The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation. Exp Eye Res. 2014 Jul; 124:67-73.
    View in: PubMed
    Score: 0.149
  29. Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. Invest Ophthalmol Vis Sci. 2014 Apr 29; 55(7):4175-85.
    View in: PubMed
    Score: 0.149
  30. EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay. PLoS One. 2014; 9(3):e91849.
    View in: PubMed
    Score: 0.148
  31. Retinal detachment model in rodents by subretinal injection of sodium hyaluronate. J Vis Exp. 2013 Sep 11; (79).
    View in: PubMed
    Score: 0.143
  32. Photoreceptor cell death and rescue in retinal detachment and degenerations. Prog Retin Eye Res. 2013 Nov; 37:114-40.
    View in: PubMed
    Score: 0.142
  33. AMP-dependent kinase inhibits oxidative stress-induced caveolin-1 phosphorylation and endocytosis by suppressing the dissociation between c-Abl and Prdx1 proteins in endothelial cells. J Biol Chem. 2013 Jul 12; 288(28):20581-91.
    View in: PubMed
    Score: 0.140
  34. Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis. PLoS One. 2013; 8(1):e52852.
    View in: PubMed
    Score: 0.136
  35. Receptor interacting protein kinase mediates necrotic cone but not rod cell death in a mouse model of inherited degeneration. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14598-603.
    View in: PubMed
    Score: 0.132
  36. Etanercept, a widely used inhibitor of tumor necrosis factor-a (TNF-a), prevents retinal ganglion cell loss in a rat model of glaucoma. PLoS One. 2012; 7(7):e40065.
    View in: PubMed
    Score: 0.131
  37. Aminoimidazole carboxamide ribonucleotide ameliorates experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2012 Jun 28; 53(7):4158-69.
    View in: PubMed
    Score: 0.131
  38. The regulatory roles of apoptosis-inducing factor in the formation and regression processes of ocular neovascularization. Am J Pathol. 2012 Jul; 181(1):53-61.
    View in: PubMed
    Score: 0.130
  39. Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse. Am J Pathol. 2012 May; 180(5):1917-27.
    View in: PubMed
    Score: 0.129
  40. Tauroursodeoxycholic acid (TUDCA) protects photoreceptors from cell death after experimental retinal detachment. PLoS One. 2011; 6(9):e24245.
    View in: PubMed
    Score: 0.124
  41. Inhibitory effect of aminoimidazole carboxamide ribonucleotide (AICAR) on endotoxin-induced uveitis in rats. Invest Ophthalmol Vis Sci. 2011 Aug 22; 52(9):6565-71.
    View in: PubMed
    Score: 0.124
  42. RIP kinase-mediated necrosis as an alternative mechanisms of photoreceptor death. Oncotarget. 2011 Jun; 2(6):497-509.
    View in: PubMed
    Score: 0.122
  43. In vivo evaluation of laser-induced choroidal neovascularization using spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3880-7.
    View in: PubMed
    Score: 0.122
  44. Edaravone, an ROS scavenger, ameliorates photoreceptor cell death after experimental retinal detachment. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3825-31.
    View in: PubMed
    Score: 0.122
  45. Utilizing targeted gene therapy with nanoparticles binding alpha v beta 3 for imaging and treating choroidal neovascularization. PLoS One. 2011 Apr 29; 6(4):e18864.
    View in: PubMed
    Score: 0.121
  46. Tumor necrosis factor-alpha mediates photoreceptor death in a rodent model of retinal detachment. Invest Ophthalmol Vis Sci. 2011 Mar; 52(3):1384-91.
    View in: PubMed
    Score: 0.120
  47. Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase. Am J Pathol. 2011 Mar; 178(3):1080-91.
    View in: PubMed
    Score: 0.120
  48. Receptor interacting protein kinases mediate retinal detachment-induced photoreceptor necrosis and compensate for inhibition of apoptosis. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21695-700.
    View in: PubMed
    Score: 0.117
  49. Retinoblastoma cells are inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase. FASEB J. 2010 Aug; 24(8):2620-30.
    View in: PubMed
    Score: 0.112
  50. A novel nonradioactive method to evaluate vascular barrier breakdown and leakage. Invest Ophthalmol Vis Sci. 2010 Mar; 51(3):1677-82.
    View in: PubMed
    Score: 0.109
  51. Review of the ocular angiogenesis animal models. Semin Ophthalmol. 2009 Mar-Apr; 24(2):52-61.
    View in: PubMed
    Score: 0.104
  52. BASELINE PREDICTORS ASSOCIATED WITH 3-YEAR CHANGES IN DARK ADAPTATION IN AGE-RELATED MACULAR DEGENERATION. Retina. 2021 Oct 01; 41(10):2098-2105.
    View in: PubMed
    Score: 0.062
  53. Wide-field swept-source optical coherence tomography angiography in the assessment of retinal microvasculature and choroidal thickness in patients with myopia. Br J Ophthalmol. 2021 Aug 12.
    View in: PubMed
    Score: 0.062
  54. Area under the dark adaptation curve as a reliable alternate measure of dark adaptation response. Br J Ophthalmol. 2021 Apr 22.
    View in: PubMed
    Score: 0.060
  55. Association of Human Plasma Metabolomics with Delayed Dark Adaptation in Age-Related Macular Degeneration. Metabolites. 2021 Mar 21; 11(3).
    View in: PubMed
    Score: 0.060
  56. Genomic-Metabolomic Associations Support the Role of LIPC and Glycerophospholipids in Age-Related Macular Degeneration. Ophthalmol Sci. 2021 Mar; 1(1).
    View in: PubMed
    Score: 0.060
  57. Widefield Swept-Source OCT Angiography Metrics Associated with the Development of Diabetic Vitreous Hemorrhage: A Prospective Study. Ophthalmology. 2021 Sep; 128(9):1312-1324.
    View in: PubMed
    Score: 0.060
  58. Contrast sensitivity function in patients with macular disease and good visual acuity. Br J Ophthalmol. 2021 Feb 03.
    View in: PubMed
    Score: 0.060
  59. Retinal applications of swept source optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). Prog Retin Eye Res. 2021 Sep; 84:100951.
    View in: PubMed
    Score: 0.059
  60. Detection of neovascularisation in the vitreoretinal interface slab using widefield swept-source optical coherence tomography angiography in diabetic retinopathy. Br J Ophthalmol. 2020 Dec 21.
    View in: PubMed
    Score: 0.059
  61. A quantitative comparison of four optical coherence tomography angiography devices in healthy eyes. Graefes Arch Clin Exp Ophthalmol. 2021 Jun; 259(6):1493-1501.
    View in: PubMed
    Score: 0.058
  62. Comparison of widefield swept-source optical coherence tomography angiography with ultra-widefield colour fundus photography and fluorescein angiography for detection of lesions in diabetic retinopathy. Br J Ophthalmol. 2021 04; 105(4):577-581.
    View in: PubMed
    Score: 0.057
  63. Subthreshold Exudative Choroidal Neovascularization Associated With Age-Related Macular Degeneration Identified by Optical Coherence Tomography Angiography. J Vitreoretin Dis. 2020 Oct; 4(5):377-385.
    View in: PubMed
    Score: 0.056
  64. Different Scan Protocols Affect the Detection Rates of Diabetic Retinopathy Lesions by Wide-Field Swept-Source Optical Coherence Tomography Angiography. Am J Ophthalmol. 2020 07; 215:72-80.
    View in: PubMed
    Score: 0.056
  65. Higher Intake of Polyunsaturated Fatty Acid and Monounsaturated Fatty Acid is Inversely Associated With AMD. Invest Ophthalmol Vis Sci. 2020 02 07; 61(2):20.
    View in: PubMed
    Score: 0.056
  66. Imaging Artifacts and Segmentation Errors With Wide-Field Swept-Source Optical Coherence Tomography Angiography in Diabetic Retinopathy. Transl Vis Sci Technol. 2019 Nov; 8(6):18.
    View in: PubMed
    Score: 0.055
  67. Validation of RetmarkerAMD as a semiautomatic grading software for AMD. Eye (Lond). 2020 03; 34(3):600-602.
    View in: PubMed
    Score: 0.054
  68. Quantitative Comparison Of Microvascular Metrics On Three Optical Coherence Tomography Angiography Devices In Chorioretinal Disease. Clin Ophthalmol. 2019; 13:2063-2069.
    View in: PubMed
    Score: 0.054
  69. Human Plasma Metabolomics in Age-Related Macular Degeneration: Meta-Analysis of Two Cohorts. Metabolites. 2019 Jul 02; 9(7).
    View in: PubMed
    Score: 0.053
  70. Urine Nuclear Magnetic Resonance (NMR) Metabolomics in Age-Related Macular Degeneration. J Proteome Res. 2019 03 01; 18(3):1278-1288.
    View in: PubMed
    Score: 0.052
  71. Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography. Br J Ophthalmol. 2019 12; 103(12):1769-1776.
    View in: PubMed
    Score: 0.052
  72. Visualization of Choriocapillaris and Choroidal Vasculature in Healthy Eyes With En Face Swept-Source Optical Coherence Tomography Versus Angiography. Transl Vis Sci Technol. 2018 Nov; 7(6):25.
    View in: PubMed
    Score: 0.051
  73. Reply. Ophthalmology. 2018 07; 125(7):e46-e47.
    View in: PubMed
    Score: 0.050
  74. HEALTH CONDITIONS LINKED TO AGE-RELATED MACULAR DEGENERATION ASSOCIATED WITH DARK ADAPTATION. Retina. 2018 Jun; 38(6):1145-1155.
    View in: PubMed
    Score: 0.049
  75. Imaging the Deep Choroidal Vasculature Using Spectral Domain and Swept Source Optical Coherence Tomography Angiography. J Vitreoretin Dis. 2018 May-Jun; 2(3):146-154.
    View in: PubMed
    Score: 0.049
  76. Peripheral Changes Associated With Delayed Dark Adaptation in Age-related Macular Degeneration. Am J Ophthalmol. 2018 06; 190:113-124.
    View in: PubMed
    Score: 0.049
  77. Novel grid combined with peripheral distortion correction for ultra-widefield image grading of age-related macular degeneration. Clin Ophthalmol. 2017; 11:1967-1974.
    View in: PubMed
    Score: 0.048
  78. Diabetic Choroidopathy: Choroidal Vascular Density and Volume in Diabetic Retinopathy With Swept-Source Optical Coherence Tomography. Am J Ophthalmol. 2017 Dec; 184:75-83.
    View in: PubMed
    Score: 0.047
  79. Human Plasma Metabolomics Study across All Stages of Age-Related Macular Degeneration Identifies Potential Lipid Biomarkers. Ophthalmology. 2018 02; 125(2):245-254.
    View in: PubMed
    Score: 0.047
  80. Choroidal Changes Associated With Subretinal Drusenoid Deposits in Age-related Macular Degeneration Using Swept-source Optical Coherence Tomography. Am J Ophthalmol. 2017 Aug; 180:55-63.
    View in: PubMed
    Score: 0.046
  81. Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy. PLoS One. 2017; 12(5):e0177749.
    View in: PubMed
    Score: 0.046
  82. Structural Changes Associated with Delayed Dark Adaptation in Age-Related Macular Degeneration. Ophthalmology. 2017 09; 124(9):1340-1352.
    View in: PubMed
    Score: 0.046
  83. Automated Brightness and Contrast Adjustment of Color Fundus Photographs for the Grading of Age-Related Macular Degeneration. Transl Vis Sci Technol. 2017 Mar; 6(2):3.
    View in: PubMed
    Score: 0.045
  84. miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells. PLoS One. 2016; 11(8):e0160887.
    View in: PubMed
    Score: 0.044
  85. An Experimental Animal Model of Photodynamic Optic Nerve Head Injury (PONHI). Curr Eye Res. 2016 11; 41(11):1498-1506.
    View in: PubMed
    Score: 0.043
  86. Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury. Sci Transl Med. 2015 Jul 22; 7(297):297ra116.
    View in: PubMed
    Score: 0.041
  87. Characterization of a spontaneous retinal neovascular mouse model. PLoS One. 2014; 9(9):e106507.
    View in: PubMed
    Score: 0.038
  88. Cytochrome P450-generated metabolites derived from ?-3 fatty acids attenuate neovascularization. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):9603-8.
    View in: PubMed
    Score: 0.038
  89. Conversion to aflibercept for chronic refractory or recurrent neovascular age-related macular degeneration. Am J Ophthalmol. 2013 Jul; 156(1):29-35.e2.
    View in: PubMed
    Score: 0.035
  90. Anti-vascular endothelial growth factor monotherapy versus combination treatment with photodynamic therapy for subfoveal choroidal neovascularization secondary to causes other than age-related macular degeneration. Retina. 2011 Nov; 31(10):2078-83.
    View in: PubMed
    Score: 0.031
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.