Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Alan Frank, Ph.D., M.D.


Targeting HER-2 Overexpressing Breast Cancer Cells: Enhancing Their Sensitivity to Chemotherapy Agents and Rescuing the Expression of Progesterone Receptors
Summer, 06/13/05 - 08/19/05
Evaluation of harmine and related compounds on NFêB inhibition and tumor survival in multiple myeloma
Part Time, 11/02/09 - 06/04/10
Targeting STAT3 in Ovarian Cancer
Summer, 06/20/11 - 08/12/11

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA160979 (FRANK, DAVID A.) May 1, 2012 - Mar 31, 2018
    Dual STAT3/NF-kB Inhibitors for Targeted Cancer Therapy
    Role: Principal Investigator
  2. R21CA122793 (FRANK, DAVID A) Jun 27, 2006 - May 31, 2009
    STAT3 in the Pathogenesis and Treatment of Pancreatic Cancer
    Role: Principal Investigator
  3. R03NS050830 (FRANK, DAVID A) Sep 30, 2004 - Aug 31, 2005
    High Throughput Screening for Modulators of STAT5 (RMI)
    Role: Principal Investigator
  4. R01CA079547 (FRANK, DAVID A) Jan 7, 1999 - Dec 31, 2004
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chen BR, Deshpande A, Barbosa K, Kleppe M, Lei X, Yeddula N, Vela PS, Campos AR, Wechsler-Reya RJ, Bagchi A, Meshinchi S, Eaves C, Jeremias I, Haferlach T, Frank DA, Ronai Z, Chanda S, Armstrong SA, Adams PD, Levine RL, Deshpande AJ. A JAK/STAT-mediated inflammatory signaling cascade drives oncogenesis in AF10-rearranged AML. Blood. 2021 Jun 17; 137(24):3403-3415. PMID: 33690798.
    Citations:    Fields:    
  2. Lapidot M, Case AE, Weisberg EL, Meng C, Walker SR, Garg S, Ni W, Podar K, Hung YP, Carrasco RD, Knott A, Gokhale PC, Sharma S, Pozhitkov A, Kulkarni P, Frank DA, Salgia R, Griffin JD, Saladi SV, Bueno R, Sattler M. Essential role of the histone lysine demethylase KDM4A in the biology of malignant pleural mesothelioma (MPM). Br J Cancer. 2021 Aug; 125(4):582-592. PMID: 34088988.
    Citations:    Fields:    
  3. Liu S, Gandler HI, Tošic I, Ye DQ, Giaccone ZT, Frank DA. Mutant KRAS Downregulates the Receptor for Leukemia Inhibitory Factor (LIF) to Enhance a Signature of Glycolysis in Pancreatic Cancer and Lung Cancer. Mol Cancer Res. 2021 Aug; 19(8):1283-1295. PMID: 33931487.
    Citations:    Fields:    
  4. Tošic I, Heppler LN, Egusquiaguirre SP, Boehnke N, Correa S, Costa DF, Moore EAG, Pal S, Richardson DS, Ivanov AR, Haas-Kogan DA, Nomura DK, Hammond PT, Frank DA. Lipidome-based Targeting of STAT3-driven Breast Cancer Cells Using Poly-l-glutamic Acid-coated Layer-by-Layer Nanoparticles. Mol Cancer Ther. 2021 04; 20(4):726-738. PMID: 33536189.
    Citations:    Fields:    
  5. Brown JR, Walker SR, Heppler LN, Tyekucheva S, Nelson EA, Klitgaard J, Nicolais M, Kroll Y, Xiang M, Yeh JE, Chaudhury M, Giaccone ZT, Fernandes SM, Jacobsen ED, Fisher DC, Freedman AS, Davids MS, Supko JG, Wu C, Frank DA. Targeting constitutively active STAT3 in chronic lymphocytic leukemia: A clinical trial of the STAT3 inhibitor pyrimethamine with pharmacodynamic analyses. Am J Hematol. 2021 04 01; 96(4):E95-E98. PMID: 33373063.
    Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
  6. Lapidot M, Case AE, Larios D, Gandler HI, Meng C, Tošic I, Weisberg EL, Poitras MJ, Gokhale PC, Paweletz CP, Podar K, Salgia R, Saladi SV, Griffin JD, Frank DA, Bueno R, Sattler M. Inhibitors of the Transcription Factor STAT3 Decrease Growth and Induce Immune Response Genes in Models of Malignant Pleural Mesothelioma (MPM). Cancers (Basel). 2020 Dec 22; 13(1). PMID: 33374980.
    Citations: 1     
  7. Wang L, Astone M, Alam SK, Zhu Z, Pei W, Frank DA, Burgess SM, Hoeppner LH. Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability. bioRxiv. 2020 Nov 20. PMID: 33140053.
  8. Niu J, Sun Y, Chen B, Zheng B, Jarugumilli GK, Walker SR, Hata AN, Mino-Kenudson M, Frank DA, Wu X. Retraction Note: Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation. Nature. 2020 07; 583(7814):154. PMID: 32555452.
    Citations:    Fields:    
  9. Cerulli RA, Shehaj L, Tosic I, Jiang K, Wang J, Frank DA, Kritzer JA. Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors. Bioorg Med Chem. 2020 06 15; 28(12):115542. PMID: 32503696.
    Citations:    Fields:    Translation:HumansCells
  10. Stevens AM, Xiang M, Heppler LN, Tošic I, Jiang K, Munoz JO, Gaikwad AS, Horton TM, Long X, Narayanan P, Seashore EL, Terrell MC, Rashid R, Krueger MJ, Mangubat-Medina AE, Ball ZT, Sumazin P, Walker SR, Hamada Y, Oyadomari S, Redell MS, Frank DA. Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation. Blood Adv. 2019 12 23; 3(24):4215-4227. PMID: 31856268.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Egusquiaguirre SP, Liu S, Tošic I, Jiang K, Walker SR, Nicolais M, Saw TY, Xiang M, Bartel K, Nelson EA, Frank DA. CDK5RAP3 is a co-factor for the oncogenic transcription factor STAT3. Neoplasia. 2020 01; 22(1):47-59. PMID: 31765941.
    Citations: 4     Fields:    Translation:HumansCells
  12. Heppler LN, Frank DA. Inhibit versus Destroy: Are PROTAC Degraders the Solution to Targeting STAT3? Cancer Cell. 2019 11 11; 36(5):459-461. PMID: 31715126.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Niu J, Sun Y, Chen B, Zheng B, Jarugumilli GK, Walker SR, Hata AN, Mino-Kenudson M, Frank DA, Wu X. Fatty acids and cancer-amplified ZDHHC19 promote STAT3 activation through S-palmitoylation. Nature. 2019 09; 573(7772):139-143. PMID: 31462771.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  14. Ganguly A, Frank D, Kumar N, Cheng YC, Chu E. Cancer Biomarkers for Integrative Oncology. Curr Oncol Rep. 2019 03 05; 21(4):32. PMID: 30834992.
    Citations: 1     Fields:    Translation:Humans
  15. Chen CH, Bhasin S, Khanna P, Joshi M, Joslin PM, Saxena R, Amin S, Liu S, Sindhu S, Walker SR, Catalano P, Frank DA, Alper SL, Bhasin M, Bhatt RS. Study of Cathepsin B inhibition in VEGFR TKI treated human renal cell carcinoma xenografts. Oncogenesis. 2019 Feb 22; 8(3):15. PMID: 30796200.
    Citations: 4     
  16. Liu S, Marneth AE, Alexe G, Walker SR, Gandler HI, Ye DQ, Labella K, Mathur R, Toniolo PA, Tillgren M, Gokhale PC, Barbie D, Mullally A, Stegmaier K, Frank DA. The kinases IKBKE and TBK1 regulate MYC-dependent survival pathways through YB-1 in AML and are targets for therapy. Blood Adv. 2018 12 11; 2(23):3428-3442. PMID: 30504235.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Shastri A, Choudhary G, Teixeira M, Gordon-Mitchell S, Ramachandra N, Bernard L, Bhattacharyya S, Lopez R, Pradhan K, Giricz O, Ravipati G, Wong LF, Cole S, Bhagat TD, Feld J, Dhar Y, Bartenstein M, Thiruthuvanathan VJ, Wickrema A, Ye BH, Frank DA, Pellagatti A, Boultwood J, Zhou T, Kim Y, MacLeod AR, Epling-Burnette PK, Ye M, McCoon P, Woessner R, Steidl U, Will B, Verma A. Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells. J Clin Invest. 2018 12 03; 128(12):5479-5488. PMID: 30252677.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  18. Frank D, Naseem S, Russo GL, Li C, Parashar K, Konopka JB, Carpino N. Phagocytes from Mice Lacking the Sts Phosphatases Have an Enhanced Antifungal Response to Candida albicans. mBio. 2018 07 17; 9(4). PMID: 30018105.
    Citations: 5     Fields:    Translation:AnimalsCells
  19. Karakasheva TA, Lin EW, Tang Q, Qiao E, Waldron TJ, Soni M, Klein-Szanto AJ, Sahu V, Basu D, Ohashi S, Baba K, Giaccone ZT, Walker SR, Frank DA, Wileyto EP, Long Q, Dunagin MC, Raj A, Diehl JA, Wong KK, Bass AJ, Rustgi AK. IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment. Cancer Res. 2018 09 01; 78(17):4957-4970. PMID: 29976575.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  20. Egusquiaguirre SP, Yeh JE, Walker SR, Liu S, Frank DA. The STAT3 Target Gene TNFRSF1A Modulates the NF-?B Pathway in Breast Cancer Cells. Neoplasia. 2018 05; 20(5):489-498. PMID: 29621649.
    Citations: 12     Fields:    Translation:HumansCells
  21. Heppler LN, Frank DA. Rare mutations provide unique insight into oncogenic potential of STAT transcription factors. J Clin Invest. 2018 01 02; 128(1):113-115. PMID: 29199995.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Heppler LN, Frank DA. Targeting Oncogenic Transcription Factors: Therapeutic Implications of Endogenous STAT Inhibitors. Trends Cancer. 2017 12; 3(12):816-827. PMID: 29198438.
    Citations: 20     Fields:    Translation:Humans
  23. Xi D, Bao T, Chen Q, Chen S, Cheng YC, Cullen J, Frank DA, Friedberg JW, Kronish I, Lee JE, Levine M, Li P, Li S, Lu W, Mao JJ, O'Keefe S, Rubinstein L, Shah MA, Standish L, Paller CJ, Chu E. State of the Science: Cancer Complementary and Alternative Medicine Therapeutics Research-NCI Strategic Workshop Highlights of Discussion Report. J Natl Cancer Inst Monogr. 2017 11 01; 2017(52). PMID: 29140484.
    Citations: 2     Fields:    Translation:Humans
  24. Khan MW, Saadalla A, Ewida AH, Al-Katranji K, Al-Saoudi G, Giaccone ZT, Gounari F, Zhang M, Frank DA, Khazaie K. The STAT3 inhibitor pyrimethamine displays anti-cancer and immune stimulatory effects in murine models of breast cancer. Cancer Immunol Immunother. 2018 01; 67(1):13-23. PMID: 28875329.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  25. Frank D. "I Was Not Sick and I Didn't Need to Recover": Methadone Maintenance Treatment (MMT) as a Refuge from Criminalization. Subst Use Misuse. 2018 01 28; 53(2):311-322. PMID: 28704148.
    Citations: 5     Fields:    Translation:Humans
  26. Daigger GT, Siczka JS, Smith TF, Frank DA, McCorquodale JA. Marrying Step Feed with Secondary Clarifier Improvements to Significantly Increase Peak Wet Weather Treatment Capacity: An Integrated Methodology. Water Environ Res. 2017 Aug 01; 89(8):724-731. PMID: 28332469.
    Citations:    Fields:    Translation:PHPublic Health
  27. Yuzugullu H, Von T, Thorpe LM, Walker SR, Roberts TM, Frank DA, Zhao JJ. NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways. Cell Discov. 2016; 2:16030. PMID: 27672444.
    Citations: 7     
  28. Xiang M, Kim H, Ho VT, Walker SR, Bar-Natan M, Anahtar M, Liu S, Toniolo PA, Kroll Y, Jones N, Giaccone ZT, Heppler LN, Ye DQ, Marineau JJ, Shaw D, Bradner JE, Blonquist T, Neuberg D, Hetz C, Stone RM, Soiffer RJ, Frank DA. Gene expression-based discovery of atovaquone as a STAT3 inhibitor and anticancer agent. Blood. 2016 10 06; 128(14):1845-1853. PMID: 27531676.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  29. Laidlaw KM, Berhan S, Liu S, Silvestri G, Holyoake TL, Frank DA, Aggarwal B, Bonner MY, Perrotti D, Jørgensen HG, Arbiser JL. Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia. Oncotarget. 2016 08 09; 7(32):51651-51664. PMID: 27438151.
    Citations: 8     Fields:    Translation:HumansCells
  30. Toniolo PA, Liu S, Yeh JE, Ye DQ, Barbuto JA, Frank DA. Deregulation of SOCS5 suppresses dendritic cell function in chronic lymphocytic leukemia. Oncotarget. 2016 Jul 19; 7(29):46301-46314. PMID: 27317770.
    Citations: 14     Fields:    Translation:HumansCells
  31. Daigger GT, Siczka JS, Smith TF, Frank DA, McCorquodale JA. Characterizing shallow secondary clarifier performance where conventional flux theory over-estimates allowable solids loading rate. Water Sci Technol. 2016; 74(2):324-32. PMID: 27438236.
    Citations:    Fields:    Translation:CellsPHPublic Health
  32. Yeh JE, Frank DA. STAT3-Interacting Proteins as Modulators of Transcription Factor Function: Implications to Targeted Cancer Therapy. ChemMedChem. 2016 Apr 19; 11(8):795-801. PMID: 26662504.
    Citations: 16     Fields:    Translation:HumansCells
  33. Lowe AC, Pignon JC, Carvo I, Drage MG, Constantine NM, Jones N, Kroll Y, Frank DA, Signoretti S, Cibas ES. Young investigator challenge: Application of cytologic techniques to circulating tumor cell specimens: Detecting activation of the oncogenic transcription factor STAT3. Cancer Cytopathol. 2015 Dec; 123(12):696-706. PMID: 26671736.
    Citations: 6     Fields:    Translation:HumansCells
  34. Walker SR, Frank DA. Targeting BCL6 and STAT3 in triple negative breast cancer: the one-two punch? Oncoscience. 2015; 2(11):912. PMID: 26697522.
    Citations: 5     
  35. Rangel J, Novoa R, Morrison C, Frank D, Kovarik C. Fistulizing Epstein-Barr virus-positive plasmablastic lymphoma in an HIV-positive man. Br J Dermatol. 2016 Feb; 174(2):398-401. PMID: 26286218.
    Citations: 1     Fields:    Translation:HumansCells
  36. Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS. Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 2015 Aug 27; 58(16):6589-606. PMID: 26258521.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  37. Byun S, Lim S, Mun JY, Kim KH, Ramadhar TR, Farrand L, Shin SH, Thimmegowda NR, Lee HJ, Frank DA, Clardy J, Lee SW, Lee KW. Identification of a Dual Inhibitor of Janus Kinase 2 (JAK2) and p70 Ribosomal S6 Kinase1 (S6K1) Pathways. J Biol Chem. 2015 Sep 25; 290(39):23553-62. PMID: 26242912.
    Citations: 3     Fields:    Translation:HumansCells
  38. Hu T, Yeh JE, Pinello L, Jacob J, Chakravarthy S, Yuan GC, Chopra R, Frank DA. Impact of the N-Terminal Domain of STAT3 in STAT3-Dependent Transcriptional Activity. Mol Cell Biol. 2015 Oct; 35(19):3284-300. PMID: 26169829.
    Citations: 17     Fields:    Translation:AnimalsCells
  39. Kreimer S, Belov AM, Ghiran I, Murthy SK, Frank DA, Ivanov AR. Mass-spectrometry-based molecular characterization of extracellular vesicles: lipidomics and proteomics. J Proteome Res. 2015 Jun 05; 14(6):2367-84. PMID: 25927954.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  40. Yeh JE, Kreimer S, Walker SR, Emori MM, Krystal H, Richardson A, Ivanov AR, Frank DA. Granulin, a novel STAT3-interacting protein, enhances STAT3 transcriptional function and correlates with poorer prognosis in breast cancer. Genes Cancer. 2015 Mar; 6(3-4):153-68. PMID: 26000098.
    Citations: 10     
  41. Toniolo PA, Liu S, Yeh JE, Moraes-Vieira PM, Walker SR, Vafaizadeh V, Barbuto JA, Frank DA. Inhibiting STAT5 by the BET bromodomain inhibitor JQ1 disrupts human dendritic cell maturation. J Immunol. 2015 Apr 01; 194(7):3180-90. PMID: 25725100.
    Citations: 21     Fields:    Translation:HumansCells
  42. Frank DA, Marrazzo J. ACP Journal Club. Review: Self-collected samples are less accurate for HPV testing than clinician-collected samples. Ann Intern Med. 2014 Aug 19; 161(4):JC11. PMID: 25133378.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  43. Frank D, Mateu-Gelabert P, Guarino H, Bennett A, Wendel T, Jessell L, Teper A. High risk and little knowledge: overdose experiences and knowledge among young adult nonmedical prescription opioid users. Int J Drug Policy. 2015 Jan; 26(1):84-91. PMID: 25151334.
    Citations: 41     Fields:    Translation:Humans
  44. Walker SR, Xiang M, Frank DA. STAT3 Activity and Function in Cancer: Modulation by STAT5 and miR-146b. Cancers (Basel). 2014 Apr 23; 6(2):958-68. PMID: 24762632.
    Citations: 12     
  45. Walker SR, Liu S, Xiang M, Nicolais M, Hatzi K, Giannopoulou E, Elemento O, Cerchietti L, Melnick A, Frank DA. The transcriptional modulator BCL6 as a molecular target for breast cancer therapy. Oncogene. 2015 Feb 26; 34(9):1073-82. PMID: 24662818.
    Citations: 32     Fields:    Translation:HumansCells
  46. Lee RE, Walker SR, Savery K, Frank DA, Gaudet S. Fold change of nuclear NF-?B determines TNF-induced transcription in single cells. Mol Cell. 2014 Mar 20; 53(6):867-79. PMID: 24530305.
    Citations: 92     Fields:    Translation:HumansCells
  47. Xiang M, Birkbak NJ, Vafaizadeh V, Walker SR, Yeh JE, Liu S, Kroll Y, Boldin M, Taganov K, Groner B, Richardson AL, Frank DA. STAT3 induction of miR-146b forms a feedback loop to inhibit the NF-?B to IL-6 signaling axis and STAT3-driven cancer phenotypes. Sci Signal. 2014 Jan 28; 7(310):ra11. PMID: 24473196.
    Citations: 68     Fields:    Translation:HumansCells
  48. Liu S, Walker SR, Nelson EA, Cerulli R, Xiang M, Toniolo PA, Qi J, Stone RM, Wadleigh M, Bradner JE, Frank DA. Targeting STAT5 in hematologic malignancies through inhibition of the bromodomain and extra-terminal (BET) bromodomain protein BRD2. . 2014 May; 13(5):1194-205. PMID: 24435449.
    Citations: 37     Translation:HumansCells
  49. Lathan C, Frank DA. ACP Journal Club. Review: low-dose CT screening reduces lung cancer and mortality in current or former smokers. Ann Intern Med. 2013 Nov 19; 159(10):JC3. PMID: 24247693.
    Citations:    Fields:    Translation:HumansPHPublic Health
  50. Frank DA. Transcription factor STAT3 as a prognostic marker and therapeutic target in cancer. J Clin Oncol. 2013 Dec 20; 31(36):4560-1. PMID: 24220556.
    Citations: 11     Fields:    Translation:HumansCells
  51. Yeh JE, Toniolo PA, Frank DA. Targeting transcription factors: promising new strategies for cancer therapy. Curr Opin Oncol. 2013 Nov; 25(6):652-8. PMID: 24048019.
    Citations: 47     Fields:    Translation:HumansCells
  52. Ajay AK, Kim TM, Ramirez-Gonzalez V, Park PJ, Frank DA, Vaidya VS. A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after kidney injury. J Am Soc Nephrol. 2014 Jan; 25(1):105-18. PMID: 24158981.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  53. Klitgaard JL, Koefoed K, Geisler C, Gadeberg OV, Frank DA, Petersen J, Jurlander J, Pedersen MW. Combination of two anti-CD5 monoclonal antibodies synergistically induces complement-dependent cytotoxicity of chronic lymphocytic leukaemia cells. Br J Haematol. 2013 Oct; 163(2):182-93. PMID: 23927424.
    Citations: 8     Fields:    Translation:HumansCells
  54. Walker SR, Nelson EA, Yeh JE, Pinello L, Yuan GC, Frank DA. STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6. Mol Cell Biol. 2013 Aug; 33(15):2879-90. PMID: 23716595.
    Citations: 39     Fields:    Translation:HumansCells
  55. Yeh JE, Toniolo PA, Frank DA. JAK2-STAT5 signaling: A novel mechanism of resistance to targeted PI3K/mTOR inhibition. JAKSTAT. 2013 Oct 01; 2(4):e24635. PMID: 24470973.
    Citations: 2     
  56. Walker SR, Xiang M, Frank DA. Distinct roles of STAT3 and STAT5 in the pathogenesis and targeted therapy of breast cancer. Mol Cell Endocrinol. 2014 Jan 25; 382(1):616-621. PMID: 23531638.
    Citations: 40     Fields:    Translation:Humans
  57. Chmielecki J, Crago AM, Rosenberg M, O'Connor R, Walker SR, Ambrogio L, Auclair D, McKenna A, Heinrich MC, Frank DA, Meyerson M. Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nat Genet. 2013 Feb; 45(2):131-2. PMID: 23313954.
    Citations: 126     Fields:    Translation:HumansCells
  58. Frank DA. Targeting STATs for cancer therapy: "Undruggable" no more. JAKSTAT. 2012 Oct 01; 1(4):261-2. PMID: 24058782.
    Citations: 2     
  59. Walker SR, Frank DA. Screening approaches to generating STAT inhibitors: Allowing the hits to identify the targets. JAKSTAT. 2012 Oct 01; 1(4):292-9. PMID: 24058786.
    Citations: 10     
  60. Greulich H, Kaplan B, Mertins P, Chen TH, Tanaka KE, Yun CH, Zhang X, Lee SH, Cho J, Ambrogio L, Liao R, Imielinski M, Banerji S, Berger AH, Lawrence MS, Zhang J, Pho NH, Walker SR, Winckler W, Getz G, Frank D, Hahn WC, Eck MJ, Mani DR, Jaffe JD, Carr SA, Wong KK, Meyerson M. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14476-81. PMID: 22908275.
    Citations: 122     Fields:    Translation:AnimalsCells
  61. Nelson EA, Walker SR, Xiang M, Weisberg E, Bar-Natan M, Barrett R, Liu S, Kharbanda S, Christie AL, Nicolais M, Griffin JD, Stone RM, Kung AL, Frank DA. The STAT5 Inhibitor Pimozide Displays Efficacy in Models of Acute Myelogenous Leukemia Driven by FLT3 Mutations. Genes Cancer. 2012 Jul; 3(7-8):503-11. PMID: 23264850.
    Citations: 50     
  62. Bar-Natan M, Nelson EA, Xiang M, Frank DA. STAT signaling in the pathogenesis and treatment of myeloid malignancies. JAKSTAT. 2012 Apr 01; 1(2):55-64. PMID: 24058751.
    Citations: 25     
  63. Bar-Natan M, Nelson EA, Walker SR, Kuang Y, Distel RJ, Frank DA. Dual inhibition of Jak2 and STAT5 enhances killing of myeloproliferative neoplasia cells. Leukemia. 2012 Jun; 26(6):1407-10. PMID: 22134716.
    Citations: 19     Fields:    Translation:HumansCells
  64. Weisberg E, Ray A, Nelson E, Adamia S, Barrett R, Sattler M, Zhang C, Daley JF, Frank D, Fox E, Griffin JD. Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells. PLoS One. 2011; 6(9):e25351. PMID: 21980431.
    Citations: 13     Fields:    Translation:HumansCells
  65. Takakura A, Nelson EA, Haque N, Humphreys BD, Zandi-Nejad K, Frank DA, Zhou J. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways. Hum Mol Genet. 2011 Nov 01; 20(21):4143-54. PMID: 21821671.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  66. Catenacci DV, Cervantes G, Yala S, Nelson EA, El-Hashani E, Kanteti R, El Dinali M, Hasina R, Brägelmann J, Seiwert T, Sanicola M, Henderson L, Grushko TA, Olopade O, Karrison T, Bang YJ, Kim WH, Tretiakova M, Vokes E, Frank DA, Kindler HL, Huet H, Salgia R. RON (MST1R) is a novel prognostic marker and therapeutic target for gastroesophageal adenocarcinoma. . 2011 Jul 01; 12(1):9-46. PMID: 21543897.
    Citations: 48     Translation:HumansCells
  67. Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme J, Walker SR, Bloushtain-Qimron N, Kim JJ, Choudhury SA, Maruyama R, Wu Z, Gönen M, Mulvey LA, Bessarabova MO, Huh SJ, Silver SJ, Kim SY, Park SY, Lee HE, Anderson KS, Richardson AL, Nikolskaya T, Nikolsky Y, Liu XS, Root DE, Hahn WC, Frank DA, Polyak K. The JAK2/STAT3 signaling pathway is required for growth of CD44?CD24? stem cell-like breast cancer cells in human tumors. J Clin Invest. 2011 Jul; 121(7):2723-35. PMID: 21633165.
    Citations: 376     Fields:    Translation:HumansAnimalsCells
  68. Nelson EA, Sharma SV, Settleman J, Frank DA. A chemical biology approach to developing STAT inhibitors: molecular strategies for accelerating clinical translation. Oncotarget. 2011 Jun; 2(6):518-24. PMID: 21680956.
    Citations: 47     Fields:    Translation:Humans
  69. Morikawa T, Baba Y, Yamauchi M, Kuchiba A, Nosho K, Shima K, Tanaka N, Huttenhower C, Frank DA, Fuchs CS, Ogino S. STAT3 expression, molecular features, inflammation patterns, and prognosis in a database of 724 colorectal cancers. Clin Cancer Res. 2011 Mar 15; 17(6):1452-62. PMID: 21310826.
    Citations: 74     Fields:    Translation:HumansCells
  70. Nelson EA, Walker SR, Weisberg E, Bar-Natan M, Barrett R, Gashin LB, Terrell S, Klitgaard JL, Santo L, Addorio MR, Ebert BL, Griffin JD, Frank DA. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011 Mar 24; 117(12):3421-9. PMID: 21233313.
    Citations: 133     Fields:    Translation:HumansCells
  71. Walker SR, Chaudhury M, Frank DA. STAT3 Inhibition by Microtubule-Targeted Drugs: Dual Molecular Effects of Chemotherapeutic Agents. Mol Cell Pharmacol. 2011 Jan 01; 3(1):13-19. PMID: 21949561.
    Citations: 9     
  72. Weisberg E, Ray A, Barrett R, Nelson E, Christie AL, Porter D, Straub C, Zawel L, Daley JF, Lazo-Kallanian S, Stone R, Galinsky I, Frank D, Kung AL, Griffin JD. Smac mimetics: implications for enhancement of targeted therapies in leukemia. Leukemia. 2010 Dec; 24(12):2100-9. PMID: 20844561.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  73. Walker SR, Chaudhury M, Nelson EA, Frank DA. Microtubule-targeted chemotherapeutic agents inhibit signal transducer and activator of transcription 3 (STAT3) signaling. Mol Pharmacol. 2010 Nov; 78(5):903-8. PMID: 20693278.
    Citations: 32     Fields:    Translation:HumansCells
  74. Subbaram S, Kuentzel M, Frank D, Dipersio CM, Chittur SV. Determination of alternate splicing events using the Affymetrix Exon 1.0 ST arrays. Methods Mol Biol. 2010; 632:63-72. PMID: 20217571.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  75. Yoda A, Yoda Y, Chiaretti S, Bar-Natan M, Mani K, Rodig SJ, West N, Xiao Y, Brown JR, Mitsiades C, Sattler M, Kutok JL, DeAngelo DJ, Wadleigh M, Piciocchi A, Dal Cin P, Bradner JE, Griffin JD, Anderson KC, Stone RM, Ritz J, Foà R, Aster JC, Frank DA, Weinstock DM. Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):252-7. PMID: 20018760.
    Citations: 124     Fields:    Translation:HumansCells
  76. Romero K, de Mars M, Frank D, Anthony M, Neville J, Kirby L, Smith K, Woosley RL. The Coalition Against Major Diseases: developing tools for an integrated drug development process for Alzheimer's and Parkinson's diseases. Clin Pharmacol Ther. 2009 Oct; 86(4):365-7. PMID: 19763117.
    Citations: 15     Fields:    Translation:Humans
  77. Frank DA. STAT6 in PMBL: pathogenic or passenger? Blood. 2009 Aug 06; 114(6):1133-4. PMID: 19661272.
    Citations: 1     Fields:    
  78. Walker SR, Nelson EA, Zou L, Chaudhury M, Signoretti S, Richardson A, Frank DA. Reciprocal effects of STAT5 and STAT3 in breast cancer. Mol Cancer Res. 2009 Jun; 7(6):966-76. PMID: 19491198.
    Citations: 66     Fields:    Translation:HumansCells
  79. Sakamoto KM, Frank DA. CREB in the pathophysiology of cancer: implications for targeting transcription factors for cancer therapy. Clin Cancer Res. 2009 Apr 15; 15(8):2583-7. PMID: 19351775.
    Citations: 109     Fields:    Translation:HumansCells
  80. Ikeuchi Y, Stegmüller J, Netherton S, Huynh MA, Masu M, Frank D, Bonni S, Bonni A. A SnoN-Ccd1 pathway promotes axonal morphogenesis in the mammalian brain. J Neurosci. 2009 Apr 01; 29(13):4312-21. PMID: 19339625.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  81. Jordan SL, Zhang X, Amos J, Frank D, Menon R, Galley R, Davis C, Kalantar T, Ladika M. Evaluation of novel synthetic conditioning polymers for shampoos. J Cosmet Sci. 2009 Mar-Apr; 60(2):239-50. PMID: 19450423.
    Citations:    Fields:    Translation:Humans
  82. Frank DA. Targeting transcription factors for cancer therapy. IDrugs. 2009 Jan; 12(1):29-33. PMID: 19127502.
    Citations: 8     Fields:    Translation:HumansAnimals
  83. Nelson EA, Walker SR, Kepich A, Gashin LB, Hideshima T, Ikeda H, Chauhan D, Anderson KC, Frank DA. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood. 2008 Dec 15; 112(13):5095-102. PMID: 18824601.
    Citations: 69     Fields:    Translation:HumansCells
  84. de la Iglesia N, Konopka G, Lim KL, Nutt CL, Bromberg JF, Frank DA, Mischel PS, Louis DN, Bonni A. Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. J Neurosci. 2008 Jun 04; 28(23):5870-8. PMID: 18524891.
    Citations: 74     Fields:    Translation:HumansCells
  85. Liddle FJ, Frank DA. STAT1 expression is not required for polyp formation in Min mice. Mol Carcinog. 2008 Feb; 47(2):75-9. PMID: 17683066.
    Citations: 6     Fields:    Translation:AnimalsCells
  86. Frank DA. Review: Prophylactic use of granulocyte colony-stimulating factor reduces febrile neutropenia and short-term mortality in cancer. ACP J Club. 2008 Jan-Feb; 148(1):7. PMID: 18170994.
    Citations: 1     Fields:    
  87. Alvarez JV, Mukherjee N, Chakravarti A, Robe P, Zhai G, Chakladar A, Loeffler J, Black P, Frank DA. A STAT3 Gene Expression Signature in Gliomas is Associated with a Poor Prognosis. Transl Oncogenomics. 2007; 2:99-105. PMID: 23641147.
    Citations: 15     
  88. Germain D, Frank DA. Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res. 2007 Oct 01; 13(19):5665-9. PMID: 17908954.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  89. Lynch RA, Etchin J, Battle TE, Frank DA. A small-molecule enhancer of signal transducer and activator of transcription 1 transcriptional activity accentuates the antiproliferative effects of IFN-gamma in human cancer cells. Cancer Res. 2007 Feb 01; 67(3):1254-61. PMID: 17283162.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  90. Frank DA. STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett. 2007 Jun 28; 251(2):199-210. PMID: 17129668.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  91. Bhattacharjee A, Xu B, Frank DA, Feldman GM, Cathcart MK. Monocyte 15-lipoxygenase expression is regulated by a novel cytosolic signaling complex with protein kinase C delta and tyrosine-phosphorylated Stat3. J Immunol. 2006 Sep 15; 177(6):3771-81. PMID: 16951338.
    Citations: 16     Fields:    Translation:HumansCells
  92. Ishii Y, Pirkmaier A, Alvarez JV, Frank DA, Keselman I, Logothetis D, Mandeli J, O'Connell MJ, Waxman S, Germain D. Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. J Natl Cancer Inst. 2006 Sep 06; 98(17):1238-47. PMID: 16954476.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  93. Stone S, Abkevich V, Russell DL, Riley R, Timms K, Tran T, Trem D, Frank D, Jammulapati S, Neff CD, Iliev D, Gress R, He G, Frech GC, Adams TD, Skolnick MH, Lanchbury JS, Gutin A, Hunt SC, Shattuck D. TBC1D1 is a candidate for a severe obesity gene and evidence for a gene/gene interaction in obesity predisposition. Hum Mol Genet. 2006 Sep 15; 15(18):2709-20. PMID: 16893906.
    Citations: 68     Fields:    Translation:HumansCells
  94. Nelson EA, Walker SR, Li W, Liu XS, Frank DA. Identification of human STAT5-dependent gene regulatory elements based on interspecies homology. J Biol Chem. 2006 Sep 08; 281(36):26216-24. PMID: 16840779.
    Citations: 11     Fields:    Translation:HumansCells
  95. Walker SR, Nelson EA, Frank DA. STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas. Oncogene. 2007 Jan 11; 26(2):224-33. PMID: 16819511.
    Citations: 60     Fields:    Translation:HumansCells
  96. Arbiser JL, Govindarajan B, Battle TE, Lynch R, Frank DA, Ushio-Fukai M, Perry BN, Stern DF, Bowden GT, Liu A, Klein E, Kolodziejski PJ, Eissa NT, Hossain CF, Nagle DG. Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar. J Invest Dermatol. 2006 Jun; 126(6):1396-402. PMID: 16614726.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  97. Liddle FJ, Alvarez JV, Poli V, Frank DA. Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants. Biochemistry. 2006 May 02; 45(17):5599-605. PMID: 16634641.
    Citations: 26     Fields:    Translation:AnimalsCells
  98. Zorn E, Nelson EA, Mohseni M, Porcheray F, Kim H, Litsa D, Bellucci R, Raderschall E, Canning C, Soiffer RJ, Frank DA, Ritz J. IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood. 2006 Sep 01; 108(5):1571-9. PMID: 16645171.
    Citations: 275     Fields:    Translation:HumansCells
  99. Battle TE, Lynch RA, Frank DA. Signal transducer and activator of transcription 1 activation in endothelial cells is a negative regulator of angiogenesis. Cancer Res. 2006 Apr 01; 66(7):3649-57. PMID: 16585190.
    Citations: 40     Fields:    Translation:HumansCells
  100. Alvarez JV, Greulich H, Sellers WR, Meyerson M, Frank DA. Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. Cancer Res. 2006 Mar 15; 66(6):3162-8. PMID: 16540667.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  101. Isomoto H, Kobayashi S, Werneburg NW, Bronk SF, Guicciardi ME, Frank DA, Gores GJ. Interleukin 6 upregulates myeloid cell leukemia-1 expression through a STAT3 pathway in cholangiocarcinoma cells. Hepatology. 2005 Dec; 42(6):1329-38. PMID: 16317687.
    Citations: 90     Fields:    Translation:HumansCells
  102. Greulich H, Chen TH, Feng W, Jänne PA, Alvarez JV, Zappaterra M, Bulmer SE, Frank DA, Hahn WC, Sellers WR, Meyerson M. Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. PLoS Med. 2005 Nov; 2(11):e313. PMID: 16187797.
    Citations: 244     Fields:    Translation:HumansAnimalsCells
  103. Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A, Frank DA. Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. Cancer Res. 2005 Jun 15; 65(12):5054-62. PMID: 15958548.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  104. Kay NE, Bone ND, Lee YK, Jelinek DF, Leland P, Battle TE, Frank DA, Puri RK. A recombinant IL-4-Pseudomonas exotoxin inhibits protein synthesis and overcomes apoptosis resistance in human CLL B cells. Leuk Res. 2005 Sep; 29(9):1009-18. PMID: 16038727.
    Citations: 7     Fields:    Translation:Humans
  105. Battle TE, Arbiser J, Frank DA. The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells. Blood. 2005 Jul 15; 106(2):690-7. PMID: 15802533.
    Citations: 61     Fields:    Translation:HumansAnimals
  106. Cerimele F, Battle T, Lynch R, Frank DA, Murad E, Cohen C, Macaron N, Sixbey J, Smith K, Watnick RS, Eliopoulos A, Shehata B, Arbiser JL. Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):175-9. PMID: 15611471.
    Citations: 51     Fields:    Translation:HumansCells
  107. Alvarez JV, Frank DA. Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis. . 2004 Nov; 3(11):1045-50. PMID: 15539936.
    Citations: 34     Translation:HumansAnimals
  108. Nelson EA, Walker SR, Alvarez JV, Frank DA. Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J Biol Chem. 2004 Dec 24; 279(52):54724-30. PMID: 15498775.
    Citations: 47     Fields:    Translation:HumansCells
  109. Dumont M, Frank D, Moisan AM, Tranchant M, Soucy P, Breton R, Labrie F, Tavtigian SV, Simard J. Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. Biochim Biophys Acta. 2004 Sep 17; 1679(3):230-47. PMID: 15358515.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  110. Yuan H, Liddle FJ, Mahajan S, Frank DA. IL-6-induced survival of colorectal carcinoma cells is inhibited by butyrate through down-regulation of the IL-6 receptor. Carcinogenesis. 2004 Nov; 25(11):2247-55. PMID: 15284182.
    Citations: 7     Fields:    Translation:HumansCells
  111. Friedberg JW, Dong DA, Li S, Kim H, Stephans K, Noonan K, Neuberg D, Gribben JG, Fisher DC, Freedman AS, Takvorian T, Jurgens R, Battle TE, Frank DA. Oral fludarabine has significant activity in patients with previously untreated chronic lymphocytic leukemia, and leads to increased STAT1 levels in vivo. Leuk Res. 2004 Feb; 28(2):139-47. PMID: 14654078.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  112. Battle TE, Castro-Malaspina H, Gribben JG, Frank DA. Sustained complete remission of CLL associated with the use of a Chinese herbal extract: case report and mechanistic analysis. Leuk Res. 2003 Sep; 27(9):859-63. PMID: 12804645.
    Citations: 4     Fields:    Translation:HumansCells
  113. Battle TE, Frank DA. STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1. Blood. 2003 Oct 15; 102(8):3016-24. PMID: 12855573.
    Citations: 16     Fields:    Translation:HumansCells
  114. Bai X, Cerimele F, Ushio-Fukai M, Waqas M, Campbell PM, Govindarajan B, Der CJ, Battle T, Frank DA, Ye K, Murad E, Dubiel W, Soff G, Arbiser JL. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J Biol Chem. 2003 Sep 12; 278(37):35501-7. PMID: 12816951.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
  115. Xu B, Bhattacharjee A, Roy B, Xu HM, Anthony D, Frank DA, Feldman GM, Cathcart MK. Interleukin-13 induction of 15-lipoxygenase gene expression requires p38 mitogen-activated protein kinase-mediated serine 727 phosphorylation of Stat1 and Stat3. Mol Cell Biol. 2003 Jun; 23(11):3918-28. PMID: 12748293.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  116. Battle TE, Wierda WG, Rassenti LZ, Zahrieh D, Neuberg D, Kipps TJ, Frank DA. In vivo activation of signal transducer and activator of transcription 1 after CD154 gene therapy for chronic lymphocytic leukemia is associated with clinical and immunologic response. Clin Cancer Res. 2003 Jun; 9(6):2166-72. PMID: 12796382.
    Citations: 6     Fields:    Translation:HumansCells
  117. Frank DA. StAT signaling in cancer: insights into pathogenesis and treatment strategies. Cancer Treat Res. 2003; 115:267-91. PMID: 12613201.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  118. Battle TE, Frank DA. The role of STATs in apoptosis. Curr Mol Med. 2002 Jun; 2(4):381-92. PMID: 12108949.
    Citations: 80     Fields:    Translation:HumansAnimals
  119. Borio L, Frank D, Mani V, Chiriboga C, Pollanen M, Ripple M, Ali S, DiAngelo C, Lee J, Arden J, Titus J, Fowler D, O'Toole T, Masur H, Bartlett J, Inglesby T. Death due to bioterrorism-related inhalational anthrax: report of 2 patients. JAMA. 2001 Nov 28; 286(20):2554-9. PMID: 11722269.
    Citations: 44     Fields:    Translation:HumansCellsPHPublic Health
  120. Vonderheide RH, Butler MO, Liu JF, Battle TE, Hirano N, Gribben JG, Frank DA, Schultze JL, Nadler LM. CD40 activation of carcinoma cells increases expression of adhesion and major histocompatibility molecules but fails to induce either CD80/CD86 expression or T cell alloreactivity. Int J Oncol. 2001 Oct; 19(4):791-8. PMID: 11562757.
    Citations: 1     Fields:    Translation:HumansCells
  121. Boeuf H, Merienne K, Jacquot S, Duval D, Zeniou M, Hauss C, Reinhardt B, Huss-Garcia Y, Dierich A, Frank DA, Hanauer A, Kedinger C. The ribosomal S6 kinases, cAMP-responsive element-binding, and STAT3 proteins are regulated by different leukemia inhibitory factor signaling pathways in mouse embryonic stem cells. J Biol Chem. 2001 Dec 07; 276(49):46204-11. PMID: 11581263.
    Citations: 14     Fields:    Translation:AnimalsCells
  122. Arbiser JL, Yeung R, Weiss SW, Arbiser ZK, Amin MB, Cohen C, Frank D, Mahajan S, Herron GS, Yang J, Onda H, Zhang HB, Bai X, Uhlmann E, Loehr A, Northrup H, Au P, Davis I, Fisher DE, Gutmann DH. The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms. Am J Pathol. 2001 Aug; 159(2):483-91. PMID: 11485907.
    Citations: 20     Fields:    Translation:HumansCells
  123. Barber DL, Beattie BK, Mason JM, Nguyen MH, Yoakim M, Neel BG, D'Andrea AD, Frank DA. A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation. Blood. 2001 Apr 15; 97(8):2230-7. PMID: 11290583.
    Citations: 9     Fields:    Translation:AnimalsCells
  124. Tavtigian SV, Simard J, Teng DH, Abtin V, Baumgard M, Beck A, Camp NJ, Carillo AR, Chen Y, Dayananth P, Desrochers M, Dumont M, Farnham JM, Frank D, Frye C, Ghaffari S, Gupte JS, Hu R, Iliev D, Janecki T, Kort EN, Laity KE, Leavitt A, Leblanc G, McArthur-Morrison J, Pederson A, Penn B, Peterson KT, Reid JE, Richards S, Schroeder M, Smith R, Snyder SC, Swedlund B, Swensen J, Thomas A, Tranchant M, Woodland AM, Labrie F, Skolnick MH, Neuhausen S, Rommens J, Cannon-Albright LA. A candidate prostate cancer susceptibility gene at chromosome 17p. Nat Genet. 2001 Feb; 27(2):172-80. PMID: 11175785.
    Citations: 152     Fields:    Translation:HumansCells
  125. Mahajan S, Gollob JA, Ritz J, Frank DA. CD2 stimulation leads to the delayed and prolonged activation of STAT1 in T cells but not NK cells. Exp Hematol. 2001 Feb; 29(2):209-20. PMID: 11166460.
    Citations: 3     Fields:    Translation:HumansCells
  126. Bayerl A, Frank D, Lenz A, Höss C, Lukas P, Feldmann HJ, Molls M. [Local tumor control and cosmetic outcome following breast-conserving surgery and radiation up to a total dose of 56 Gy without boost in breast cancer]. Strahlenther Onkol. 2001 Jan; 177(1):25-32. PMID: 11200109.
    Citations:    Fields:    Translation:Humans
  127. Frank DA, Meuse J, Hirsch D, Ibrahim JG, van den Abbeele AD. The treatment and outcome of cancer patients with thromboses on central venous catheters. J Thromb Thrombolysis. 2000 Dec; 10(3):271-5. PMID: 11122548.
    Citations: 5     Fields:    Translation:Humans
  128. LaMontagne KR, Moses MA, Wiederschain D, Mahajan S, Holden J, Ghazizadeh H, Frank DA, Arbiser JL. Inhibition of MAP kinase kinase causes morphological reversion and dissociation between soft agar growth and in vivo tumorigenesis in angiosarcoma cells. Am J Pathol. 2000 Dec; 157(6):1937-45. PMID: 11106566.
    Citations: 18     Fields:    Translation:AnimalsCells
  129. Duarte RF, Frank DA. SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways. Blood. 2000 Nov 15; 96(10):3422-30. PMID: 11071637.
    Citations: 19     Fields:    Translation:HumansCells
  130. Ribisi S, Mariani FV, Aamar E, Lamb TM, Frank D, Harland RM. Ras-mediated FGF signaling is required for the formation of posterior but not anterior neural tissue in Xenopus laevis. Dev Biol. 2000 Nov 01; 227(1):183-96. PMID: 11076686.
    Citations: 24     Fields:    Translation:AnimalsCells
  131. Gollob JA, Veenstra KG, Jyonouchi H, Kelly AM, Ferrieri P, Panka DJ, Altare F, Fieschi C, Casanova JL, Frank DA, Mier JW. Impairment of STAT activation by IL-12 in a patient with atypical mycobacterial and staphylococcal infections. J Immunol. 2000 Oct 01; 165(7):4120-6. PMID: 11034424.
    Citations: 9     Fields:    Translation:HumansCells
  132. Karras JG, McKay RA, Lu T, Pych J, Frank DA, Rothstein TL, Monia BP. STAT3 regulates the growth and immunoglobulin production of BCL(1) B cell lymphoma through control of cell cycle progression. Cell Immunol. 2000 Jun 15; 202(2):124-35. PMID: 10896772.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  133. Lin TS, Mahajan S, Frank DA. STAT signaling in the pathogenesis and treatment of leukemias. Oncogene. 2000 May 15; 19(21):2496-504. PMID: 10851048.
    Citations: 66     Fields:    Translation:HumansCells
  134. Wang KS, Frank DA, Ritz J. Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood. 2000 May 15; 95(10):3183-90. PMID: 10807786.
    Citations: 61     Fields:    Translation:HumansCells
  135. Wilbanks AM, Mahajan S, Frank DA, Druker BJ, Gilliland DG, Carroll M. TEL/PDGFbetaR fusion protein activates STAT1 and STAT5: a common mechanism for transformation by tyrosine kinase fusion proteins. Exp Hematol. 2000 May; 28(5):584-93. PMID: 10812249.
    Citations: 12     Fields:    Translation:HumansCells
  136. Sillaber C, Gesbert F, Frank DA, Sattler M, Griffin JD. STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells. Blood. 2000 Mar 15; 95(6):2118-25. PMID: 10706883.
    Citations: 56     Fields:    Translation:AnimalsCells
  137. Duarte RF, Frank DA. [The JAK-STAT signaling pathway and its role in oncogenesis, immunomodulation and development]. Med Clin (Barc). 2000 Feb 19; 114(6):227-34. PMID: 10757107.
    Citations:    Fields:    Translation:HumansAnimalsCells
  138. Frank D, Mendelsohn CL, Ciccone E, Svensson K, Ohlsson R, Tycko B. A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Mamm Genome. 1999 Dec; 10(12):1150-9. PMID: 10594239.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  139. Turkson J, Bowman T, Adnane J, Zhang Y, Djeu JY, Sekharam M, Frank DA, Holzman LB, Wu J, Sebti S, Jove R. Requirement for Ras/Rac1-mediated p38 and c-Jun N-terminal kinase signaling in Stat3 transcriptional activity induced by the Src oncoprotein. Mol Cell Biol. 1999 Nov; 19(11):7519-28. PMID: 10523640.
    Citations: 69     Fields:    Translation:AnimalsCells
  140. Frank DA, McCarten KM, Robson CD, Mirochnick M, Cabral H, Park H, Zuckerman B. Level of in utero cocaine exposure and neonatal ultrasound findings. Pediatrics. 1999 Nov; 104(5 Pt 1):1101-5. PMID: 10545554.
    Citations: 31     Fields:    Translation:Humans
  141. Frank DA. STAT signaling in the pathogenesis and treatment of cancer. Mol Med. 1999 Jul; 5(7):432-56. PMID: 10449805.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  142. Ho JM, Beattie BK, Squire JA, Frank DA, Barber DL. Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signaling. Blood. 1999 Jun 15; 93(12):4354-64. PMID: 10361134.
    Citations: 18     Fields:    Translation:AnimalsCells
  143. Smith D, Buckle GJ, Hafler DA, Frank DA, Höllsberg P. HTLV-I-infected T cells evade the antiproliferative action of IFN-beta. Virology. 1999 May 10; 257(2):314-21. PMID: 10329542.
    Citations: 8     Fields:    Translation:HumansCells
  144. Gollob JA, Schnipper CP, Murphy EA, Ritz J, Frank DA. The functional synergy between IL-12 and IL-2 involves p38 mitogen-activated protein kinase and is associated with the augmentation of STAT serine phosphorylation. J Immunol. 1999 Apr 15; 162(8):4472-81. PMID: 10201984.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  145. Frank DA, Mahajan S, Ritz J. Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling. Nat Med. 1999 Apr; 5(4):444-7. PMID: 10202937.
    Citations: 64     Fields:    Translation:HumansCells
  146. Wang KS, Ritz J, Frank DA. IL-2 induces STAT4 activation in primary NK cells and NK cell lines, but not in T cells. J Immunol. 1999 Jan 01; 162(1):299-304. PMID: 9886399.
    Citations: 21     Fields:    Translation:HumansCells
  147. van Eyndhoven WG, Frank D, Kalachikov S, Cleary AM, Hong DI, Cho E, Nasr S, Perez AJ, Mackus WJ, Cayanis E, Wellington S, Fischer SG, Warburton D, Lederman S. A single gene for human TRAF-3 at chromosome 14q32.3 encodes a variety of mRNA species by alternative polyadenylation, mRNA splicing and transcription initiation. Mol Immunol. 1998 Dec; 35(18):1189-206. PMID: 10199393.
    Citations: 7     Fields:    Translation:HumansCells
  148. Needlman R, Frank DA, Cabral H, Mirochnick M, Kwon C, Zuckerman B. Blood pressure in children exposed prenatally to cocaine. Clin Pediatr (Phila). 1998 Nov; 37(11):659-64. PMID: 9825209.
    Citations: 3     Fields:    Translation:Humans
  149. Gollob JA, Schnipper CP, Orsini E, Murphy E, Daley JF, Lazo SB, Frank DA, Neuberg D, Ritz J. Characterization of a novel subset of CD8(+) T cells that expands in patients receiving interleukin-12. J Clin Invest. 1998 Aug 01; 102(3):561-75. PMID: 9691093.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  150. Frank DA, Augustyn M, Zuckerman BS. Neonatal neurobehavioral and neuroanatomic correlates of prenatal cocaine exposure. Problems of dose and confounding. Ann N Y Acad Sci. 1998 Jun 21; 846:40-50. PMID: 9668396.
    Citations: 11     Fields:    Translation:Humans
  151. Dao D, Frank D, Qian N, O'Keefe D, Vosatka RJ, Walsh CP, Tycko B. IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes. Hum Mol Genet. 1998 Apr; 7(4):597-608. PMID: 9499412.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  152. Gollob JA, Murphy EA, Mahajan S, Schnipper CP, Ritz J, Frank DA. Altered interleukin-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1. Blood. 1998 Feb 15; 91(4):1341-54. PMID: 9454765.
    Citations: 14     Fields:    Translation:HumansCells
  153. Frank DA, Mahajan S, Ritz J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues. J Clin Invest. 1997 Dec 15; 100(12):3140-8. PMID: 9399961.
    Citations: 84     Fields:    Translation:HumansCells
  154. Karras JG, Wang Z, Huo L, Frank DA, Rothstein TL. Induction of STAT protein signaling through the CD40 receptor in B lymphocytes: distinct STAT activation following surface Ig and CD40 receptor engagement. J Immunol. 1997 Nov 01; 159(9):4350-5. PMID: 9379031.
    Citations: 12     Fields:    Translation:AnimalsCells
  155. Qian N, Frank D, O'Keefe D, Dao D, Zhao L, Yuan L, Wang Q, Keating M, Walsh C, Tycko B. The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. Hum Mol Genet. 1997 Nov; 6(12):2021-9. PMID: 9328465.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  156. Bonni A, Sun Y, Nadal-Vicens M, Bhatt A, Frank DA, Rozovsky I, Stahl N, Yancopoulos GD, Greenberg ME. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway. Science. 1997 Oct 17; 278(5337):477-83. PMID: 9334309.
    Citations: 293     Fields:    Translation:AnimalsCells
  157. Teng DH, Perry WL, Hogan JK, Baumgard M, Bell R, Berry S, Davis T, Frank D, Frye C, Hattier T, Hu R, Jammulapati S, Janecki T, Leavitt A, Mitchell JT, Pero R, Sexton D, Schroeder M, Su PH, Swedlund B, Kyriakis JM, Avruch J, Bartel P, Wong AK, Tavtigian SV, et al. Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor. Cancer Res. 1997 Oct 01; 57(19):4177-82. PMID: 9331070.
    Citations: 58     Fields:    Translation:HumansCells
  158. Karras JG, Wang Z, Huo L, Howard RG, Frank DA, Rothstein TL. Signal transducer and activator of transcription-3 (STAT3) is constitutively activated in normal, self-renewing B-1 cells but only inducibly expressed in conventional B lymphocytes. J Exp Med. 1997 Mar 17; 185(6):1035-42. PMID: 9091577.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  159. Arbiser JL, Moses MA, Fernandez CA, Ghiso N, Cao Y, Klauber N, Frank D, Brownlee M, Flynn E, Parangi S, Byers HR, Folkman J. Oncogenic H-ras stimulates tumor angiogenesis by two distinct pathways. Proc Natl Acad Sci U S A. 1997 Feb 04; 94(3):861-6. PMID: 9023347.
    Citations: 121     Fields:    Translation:AnimalsCells
  160. Frank DA, Varticovski L. BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia. 1996 Nov; 10(11):1724-30. PMID: 8892675.
    Citations: 22     Fields:    Translation:AnimalsCells
  161. Karras JG, Huo L, Wang Z, Frank DA, Zimmet JM, Rothstein TL. Delayed tyrosine phosphorylation and nuclear expression of STAT1 following antigen receptor stimulation of B lymphocytes. J Immunol. 1996 Sep 15; 157(6):2299-309. PMID: 8805627.
    Citations: 5     Fields:    Translation:AnimalsCells
  162. Karras JG, Wang Z, Coniglio SJ, Frank DA, Rothstein TL. Antigen-receptor engagement in B cells induces nuclear expression of STAT5 and STAT6 proteins that bind and transactivate an IFN-gamma activation site. J Immunol. 1996 Jul 01; 157(1):39-47. PMID: 8683142.
    Citations: 6     Fields:    Translation:AnimalsCells
  163. Tronick EZ, Frank DA, Cabral H, Mirochnick M, Zuckerman B. Late dose-response effects of prenatal cocaine exposure on newborn neurobehavioral performance. Pediatrics. 1996 Jul; 98(1):76-83. PMID: 8668416.
    Citations: 36     Fields:    Translation:HumansAnimals
  164. Carlesso N, Frank DA, Griffin JD. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med. 1996 Mar 01; 183(3):811-20. PMID: 8642285.
    Citations: 113     Fields:    Translation:HumansCells
  165. Frank DA, Greenberg ME. Signal transduction pathways activated by ciliary neurotrophic factor and related cytokines. Perspect Dev Neurobiol. 1996; 4(1):3-18. PMID: 9169915.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  166. Chauhan D, Kharbanda SM, Ogata A, Urashima M, Frank D, Malik N, Kufe DW, Anderson KC. Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells. J Exp Med. 1995 Dec 01; 182(6):1801-6. PMID: 7500025.
    Citations: 10     Fields:    Translation:HumansCells
  167. Inhorn RC, Carlesso N, Durstin M, Frank DA, Griffin JD. Identification of a viability domain in the granulocyte/macrophage colony-stimulating factor receptor beta-chain involving tyrosine-750. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8665-9. PMID: 7567993.
    Citations: 8     Fields:    Translation:AnimalsCells
  168. Frank DA, Robertson MJ, Bonni A, Ritz J, Greenberg ME. Interleukin 2 signaling involves the phosphorylation of Stat proteins. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7779-83. PMID: 7544001.
    Citations: 30     Fields:    Translation:HumansCells
  169. Sattler M, Durstin MA, Frank DA, Okuda K, Kaushansky K, Salgia R, Griffin JD. The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases. Exp Hematol. 1995 Aug; 23(9):1040-8. PMID: 7543416.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  170. Peterson KE, Wiecha JL, Casey V, Meyers A, Roos N, Frank DA. Assessing unmet need for services for pediatric undernutrition. HSPH MPH Student Research Team. Am J Prev Med. 1995 May-Jun; 11(3 Suppl):39-44. PMID: 7669361.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  171. Van Adelsberg JS, Frank D. The PKD1 gene produces a developmentally regulated protein in mesenchyme and vasculature. Nat Med. 1995 Apr; 1(4):359-64. PMID: 7585067.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  172. Frank D, Cesarman E, Liu YF, Michler RE, Knowles DM. Posttransplantation lymphoproliferative disorders frequently contain type A and not type B Epstein-Barr virus. Blood. 1995 Mar 01; 85(5):1396-403. PMID: 7858270.
    Citations: 25     Fields:    Translation:HumansCells
  173. Frank DA, Greenberg ME. CREB: a mediator of long-term memory from mollusks to mammals. Cell. 1994 Oct 07; 79(1):5-8. PMID: 7923377.
    Citations: 99     Fields:    Translation:AnimalsCells
  174. Brandeis M, Frank D, Keshet I, Siegfried Z, Mendelsohn M, Nemes A, Temper V, Razin A, Cedar H. Sp1 elements protect a CpG island from de novo methylation. Nature. 1994 Sep 29; 371(6496):435-8. PMID: 8090226.
    Citations: 224     Fields:    Translation:AnimalsCells
  175. Bonni A, Frank DA, Schindler C, Greenberg ME. Characterization of a pathway for ciliary neurotrophic factor signaling to the nucleus. Science. 1993 Dec 03; 262(5139):1575-9. PMID: 7504325.
    Citations: 34     Fields:    Translation:HumansCells
  176. Frank DA, Zuckerman BS. Children exposed to cocaine prenatally: pieces of the puzzle. Neurotoxicol Teratol. 1993 Sep-Oct; 15(5):298-300; discussion 311-2. PMID: 8277921.
    Citations: 1     Fields:    Translation:Humans
  177. Frank D, Patterson B, Guthrie C. Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol. 1992 Nov; 12(11):5197-205. PMID: 1406691.
    Citations: 57     Fields:    Translation:AnimalsCells
  178. Frank DA, Bauchner H, Zuckerman BS, Fried L. Cocaine and marijuana use during pregnancy by women intending and not intending to breast-feed. J Am Diet Assoc. 1992 Feb; 92(2):215-7. PMID: 1310702.
    Citations:    Fields:    Translation:Humans
  179. Frank DA, Bauchner H, Parker S, Huber AM, Kyei-Aboagye K, Cabral H, Zuckerman B. Neonatal body proportionality and body composition after in utero exposure to cocaine and marijuana. J Pediatr. 1990 Oct; 117(4):622-6. PMID: 2213392.
    Citations: 21     Fields:    Translation:Humans
  180. Zuckerman B, Frank DA, Hingson R, Amaro H, Levenson SM, Kayne H, Parker S, Vinci R, Aboagye K, Fried LE, et al. Effects of maternal marijuana and cocaine use on fetal growth. N Engl J Med. 1989 Mar 23; 320(12):762-8. PMID: 2784193.
    Citations: 108     Fields:    Translation:Humans
  181. Frank DA, Sartorelli AC. Biochemical characterization of tyrosine kinase and phosphotyrosine phosphatase activities of HL-60 leukemia cells. Cancer Res. 1988 Aug 01; 48(15):4299-306. PMID: 2455595.
    Citations: 3     Fields:    Translation:HumansCells
  182. Frank DA, Kern EB, Kispert DB. Measurement of large or irregular-shaped septal perforations by computed tomography. Radiol Technol. 1988 May-Jun; 59(5):409-12. PMID: 3387571.
    Citations: 1     Fields:    Translation:Humans
  183. Frank DA, Sartorelli AC. Alterations in tyrosine phosphorylation during the granulocytic maturation of HL-60 leukemia cells. Cancer Res. 1988 Jan 01; 48(1):52-8. PMID: 2825968.
    Citations: 1     Fields:    Translation:HumansCells
  184. Frank DA, Wirtz SJ, Sorenson JR, Heeren T. Commercial discharge packs and breast-feeding counseling: effects on infant-feeding practices in a randomized trial. Pediatrics. 1987 Dec; 80(6):845-54. PMID: 3684395.
    Citations: 27     Fields:    Translation:HumansCTClinical Trials
  185. Frank DA, Sartorelli AC. Regulation of protein phosphotyrosine content by changes in tyrosine kinase and protein phosphotyrosine phosphatase activities during induced granulocytic and monocytic differentiation of HL-60 leukemia cells. Biochem Biophys Res Commun. 1986 Oct 15; 140(1):440-7. PMID: 2430565.
    Citations: 10     Fields:    Translation:HumansCells