Harvard Catalyst Profiles

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Dora M. Kovacs, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS045860 (TANZI, RUDOLPH EMILE) Sep 23, 2002 - Jun 30, 2023
    Role of MAMs in stabilization and BACE1-mediated processing of palAPP.
    Role: Co-Principal Investigator
  2. P01AG015379 (SELKOE, DENNIS J) Sep 30, 1998 - Apr 30, 2024
    Presenilin Biology and the Mechanisms of Alzheimer's Disease
    Role: Co-Principal Investigator
  3. R01AG014713 (KIM, DOO YEON) Aug 15, 1997 - Feb 29, 2020
    Alzheimer's BACE1 inhibition regulates neuronal contactin function
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bhattacharyya R, Black SE, Lotlikar MS, Fenn RH, Jorfi M, Kovacs DM, Tanzi RE. Axonal generation of amyloid-ß from palmitoylated APP in mitochondria-associated endoplasmic reticulum membranes. Cell Rep. 2021 May 18; 35(7):109134. PMID: 34010653.
    Citations:    Fields:    
  2. Bhattacharyya R, Fenn RH, Barren C, Tanzi RE, Kovacs DM. Palmitoylated APP Forms Dimers, Cleaved by BACE1. PLoS One. 2016; 11(11):e0166400. PMID: 27875558.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  3. Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016 Mar 31; 14:25. PMID: 27036734.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  4. Gautam V, D'Avanzo C, Berezovska O, Tanzi RE, Kovacs DM. Synaptotagmins interact with APP and promote Aß generation. Mol Neurodegener. 2015 Jul 23; 10:31. PMID: 26202512.
    Citations: 15     Fields:    Translation:AnimalsCells
  5. D'Avanzo C, Sliwinski C, Wagner SL, Tanzi RE, Kim DY, Kovacs DM. ?-Secretase modulators reduce endogenous amyloid ß42 levels in human neural progenitor cells without altering neuronal differentiation. FASEB J. 2015 Aug; 29(8):3335-41. PMID: 25903103.
    Citations: 4     Fields:    Translation:HumansCells
  6. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. PMID: 25307057.
    Citations: 314     Fields:    Translation:HumansCells
  7. Gautam V, D'Avanzo C, Hebisch M, Kovacs DM, Kim DY. BACE1 activity regulates cell surface contactin-2 levels. Mol Neurodegener. 2014 Jan 09; 9:4. PMID: 24405708.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  8. Kim DY, Wertz MH, Gautam V, D'Avanzo C, Bhattacharyya R, Kovacs DM. The E280A presenilin mutation reduces voltage-gated sodium channel levels in neuronal cells. Neurodegener Dis. 2014; 13(2-3):64-68. PMID: 24217025.
    Citations: 3     Fields:    Translation:AnimalsCells
  9. Bhattacharyya R, Barren C, Kovacs DM. Palmitoylation of amyloid precursor protein regulates amyloidogenic processing in lipid rafts. J Neurosci. 2013 Jul 03; 33(27):11169-83. PMID: 23825420.
    Citations: 46     Fields:    Translation:AnimalsCells
  10. Dong Y, Wu X, Zhang G, Xu Z, Zhang Y, Gautam V, Kovacs DM, Wu A, Yue Y, Xie Z. Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons. Curr Mol Med. 2013 May; 13(4):488-98. PMID: 22950384.
    Citations: 8     Fields:    Translation:AnimalsCells
  11. Sachse CC, Kim YH, Agsten M, Huth T, Alzheimer C, Kovacs DM, Kim DY. BACE1 and presenilin/?-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels. FASEB J. 2013 Jun; 27(6):2458-67. PMID: 23504710.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  12. Kim DY, Kovacs DM. Surface trafficking of sodium channels in cells and in hippocampal slices. Methods Mol Biol. 2011; 793:351-61. PMID: 21913112.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  13. Haapasalo A, Kovacs DM. The many substrates of presenilin/?-secretase. J Alzheimers Dis. 2011; 25(1):3-28. PMID: 21335653.
    Citations: 192     Fields:    Translation:HumansAnimals
  14. Kim DY, Gersbacher MT, Inquimbert P, Kovacs DM. Reduced sodium channel Na(v)1.1 levels in BACE1-null mice. J Biol Chem. 2011 Mar 11; 286(10):8106-8116. PMID: 21190943.
    Citations: 41     Fields:    Translation:HumansAnimals
  15. Gersbacher MT, Kim DY, Bhattacharyya R, Kovacs DM. Identification of BACE1 cleavage sites in human voltage-gated sodium channel beta 2 subunit. Mol Neurodegener. 2010 Dec 23; 5:61. PMID: 21182789.
    Citations: 21     Fields:    
  16. Kovacs DM, Gersbacher MT, Kim DY. Alzheimer's secretases regulate voltage-gated sodium channels. Neurosci Lett. 2010 Dec 10; 486(2):68-72. PMID: 20817076.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  17. Huttunen HJ, Havas D, Peach C, Barren C, Duller S, Xia W, Frosch MP, Hutter-Paier B, Windisch M, Kovacs DM. The acyl-coenzyme A: cholesterol acyltransferase inhibitor CI-1011 reverses diffuse brain amyloid pathology in aged amyloid precursor protein transgenic mice. J Neuropathol Exp Neurol. 2010 Aug; 69(8):777-88. PMID: 20613640.
    Citations: 20     Fields:    Translation:HumansAnimals
  18. Bhattacharyya R, Kovacs DM. ACAT inhibition and amyloid beta reduction. Biochim Biophys Acta. 2010 Aug; 1801(8):960-5. PMID: 20398792.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  19. Vassar R, Kovacs DM, Yan R, Wong PC. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. J Neurosci. 2009 Oct 14; 29(41):12787-94. PMID: 19828790.
    Citations: 217     Fields:    Translation:HumansAnimals
  20. Huttunen HJ, Peach C, Bhattacharyya R, Barren C, Pettingell W, Hutter-Paier B, Windisch M, Berezovska O, Kovacs DM. Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway. FASEB J. 2009 Nov; 23(11):3819-28. PMID: 19625658.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  21. Huttunen HJ, Puglielli L, Ellis BC, MacKenzie Ingano LA, Kovacs DM. Novel N-terminal cleavage of APP precludes Abeta generation in ACAT-defective AC29 cells. J Mol Neurosci. 2009 Jan; 37(1):6-15. PMID: 18618086.
    Citations: 9     Fields:    Translation:AnimalsCells
  22. Huttunen HJ, Kovacs DM. ACAT as a drug target for Alzheimer's disease. Neurodegener Dis. 2008; 5(3-4):212-4. PMID: 18322393.
    Citations: 11     Fields:    Translation:HumansAnimals
  23. Huttunen HJ, Guénette SY, Peach C, Greco C, Xia W, Kim DY, Barren C, Tanzi RE, Kovacs DM. HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. J Biol Chem. 2007 Sep 21; 282(38):28285-95. PMID: 17684015.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  24. Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol. 2007 Jul; 9(7):755-64. PMID: 17576410.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  25. Huttunen HJ, Greco C, Kovacs DM. Knockdown of ACAT-1 reduces amyloidogenic processing of APP. FEBS Lett. 2007 Apr 17; 581(8):1688-92. PMID: 17412327.
    Citations: 24     Fields:    Translation:HumansCells
  26. Haapasalo A, Kim DY, Carey BW, Turunen MK, Pettingell WH, Kovacs DM. Presenilin/gamma-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase with beta-catenin. J Biol Chem. 2007 Mar 23; 282(12):9063-72. PMID: 17259169.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  27. Carey BW, Kim DY, Kovacs DM. Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC Class I proteins. Biochem J. 2007 Jan 01; 401(1):121-7. PMID: 17150042.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  28. Zhang M, Haapasalo A, Kim DY, Ingano LA, Pettingell WH, Kovacs DM. Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment. FASEB J. 2006 Jun; 20(8):1176-8. PMID: 16645046.
    Citations: 28     Fields:    Translation:AnimalsCells
  29. Kovacs I, Lentini KM, Ingano LM, Kovacs DM. Presenilin 1 forms aggresomal deposits in response to heat shock. J Mol Neurosci. 2006; 29(1):9-19. PMID: 16757805.
    Citations: 9     Fields:    Translation:AnimalsCells
  30. Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI. Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J Clin Invest. 2005 Sep; 115(9):2556-63. PMID: 16127459.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  31. Kim DY, Ingano LA, Carey BW, Pettingell WH, Kovacs DM. Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration. J Biol Chem. 2005 Jun 17; 280(24):23251-61. PMID: 15833746.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  32. Hutter-Paier B, Huttunen HJ, Puglielli L, Eckman CB, Kim DY, Hofmeister A, Moir RD, Domnitz SB, Frosch MP, Windisch M, Kovacs DM. The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron. 2004 Oct 14; 44(2):227-38. PMID: 15473963.
    Citations: 88     Fields:    Translation:HumansAnimals
  33. Xie Z, Romano DM, Kovacs DM, Tanzi RE. Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation. J Biol Chem. 2004 Aug 13; 279(33):34130-7. PMID: 15184387.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  34. Puglielli L, Ellis BC, Ingano LA, Kovacs DM. Role of acyl-coenzyme a: cholesterol acyltransferase activity in the processing of the amyloid precursor protein. J Mol Neurosci. 2004; 24(1):93-6. PMID: 15314256.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  35. Xie Z, Moir RD, Romano DM, Tesco G, Kovacs DM, Tanzi RE. Hypocapnia induces caspase-3 activation and increases Abeta production. Neurodegener Dis. 2004; 1(1):29-37. PMID: 16908971.
    Citations: 11     Fields:    Translation:HumansCells
  36. Puglielli L, Tanzi RE, Kovacs DM. Alzheimer's disease: the cholesterol connection. Nat Neurosci. 2003 Apr; 6(4):345-51. PMID: 12658281.
    Citations: 237     Fields:    Translation:HumansAnimalsCells
  37. Puglielli L, Ellis BC, Saunders AJ, Kovacs DM. Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis. J Biol Chem. 2003 May 30; 278(22):19777-83. PMID: 12649271.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  38. Kimberly WT, Kovacs DM, Walsh D, Lashuel H, Lemere CA. The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid. 2003 Mar; 10(1):51-61. PMID: 12762144.
    Citations:    Fields:    Translation:HumansAnimals
  39. Kim DY, Ingano LA, Kovacs DM. Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage. J Biol Chem. 2002 Dec 20; 277(51):49976-81. PMID: 12376527.
    Citations: 47     Fields:    Translation:AnimalsCells
  40. Kovacs D, Mahon J, Palmer RL. Chewing and spitting out food among eating-disordered patients. Int J Eat Disord. 2002 Jul; 32(1):112-5. PMID: 12183939.
    Citations: 5     Fields:    Translation:Humans
  41. Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct; 3(10):905-12. PMID: 11584272.
    Citations: 119     Fields:    Translation:HumansAnimalsCells
  42. Puglielli L, Kovacs DM. Alzheimer disease: 100 years later. Rev Med Chil. 2001 May; 129(5):569-75. PMID: 11464541.
    Citations:    Fields:    Translation:Humans
  43. Kovacs DM. alpha2-macroglobulin in late-onset Alzheimer's disease. Exp Gerontol. 2000 Jul; 35(4):473-9. PMID: 10959035.
    Citations: 25     Fields:    Translation:Humans
  44. Abbenante G, Kovacs DM, Leung DL, Craik DJ, Tanzi RE, Fairlie DP. Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site. Biochem Biophys Res Commun. 2000 Feb 05; 268(1):133-5. PMID: 10652226.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  45. Ingano LA, Lentini KM, Kovacs I, Tanzi RE, Kovacs DM. Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cells. Ann N Y Acad Sci. 2000; 920:259-60. PMID: 11193161.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  46. Kovacs DM, Mancini R, Henderson J, Na SJ, Schmidt SD, Kim TW, Tanzi RE. Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells. J Neurochem. 1999 Dec; 73(6):2278-85. PMID: 10582585.
    Citations: 16     Fields:    Translation:HumansCells
  47. Kovacs DM, Tanzi RE. Monogenic determinants of familial Alzheimer's disease: presenilin-1 mutations. Cell Mol Life Sci. 1998 Sep; 54(9):902-9. PMID: 9791532.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  48. Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science. 1997 Jul 18; 277(5324):373-6. PMID: 9219695.
    Citations: 59     Fields:    Translation:AnimalsCells
  49. Seeger M, Nordstedt C, Petanceska S, Kovacs DM, Gouras GK, Hahne S, Fraser P, Levesque L, Czernik AJ, George-Hyslop PS, Sisodia SS, Thinakaran G, Tanzi RE, Greengard P, Gandy S. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):5090-4. PMID: 9144195.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  50. Kovacs DM, Fausett HJ, Page KJ, Kim TW, Moir RD, Merriam DE, Hollister RD, Hallmark OG, Mancini R, Felsenstein KM, Hyman BT, Tanzi RE, Wasco W. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med. 1996 Feb; 2(2):224-9. PMID: 8574969.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  51. Tanzi RE, Kovacs DM, Kim TW, Moir RD, Guenette SY, Wasco W. The gene defects responsible for familial Alzheimer's disease. Neurobiol Dis. 1996; 3(3):159-68. PMID: 8980016.
    Citations: 62     Fields:    Translation:HumansAnimals
  52. Kovacs DM, Wasco W, Witherby J, Felsenstein KM, Brunel F, Roeder RG, Tanzi RE. The upstream stimulatory factor functionally interacts with the Alzheimer amyloid beta-protein precursor gene. Hum Mol Genet. 1995 Sep; 4(9):1527-33. PMID: 8541835.
    Citations: 4     Fields:    Translation:HumansCells
  53. Wasco W, Pettingell WP, Jondro PD, Schmidt SD, Gurubhagavatula S, Rodes L, DiBlasi T, Romano DM, Guenette SY, Kovacs DM, et al. Familial Alzheimer's chromosome 14 mutations. Nat Med. 1995 Sep; 1(9):848. PMID: 7585193.
    Citations: 21     Fields:    Translation:HumansCells
  54. Kovacs DM, Kaplan BB. Discordant estimates of heterologous promoter activity as determined by reporter gene mRNA levels and enzyme activity. Biochem Biophys Res Commun. 1992 Dec 15; 189(2):912-8. PMID: 1335248.
    Citations: 1     Fields:    Translation:HumansCells
  55. Miner LL, Pandalai SP, Weisberg EP, Sell SL, Kovacs DM, Kaplan BB. Cold-induced alterations in the binding of adrenomedullary nuclear proteins to the promoter region of the tyrosine hydroxylase gene. J Neurosci Res. 1992 Sep; 33(1):10-8. PMID: 1360541.
    Citations: 3     Fields:    Translation:AnimalsCells
  56. LeBlanc AC, Kovacs DM, Chen HY, Villaré F, Tykocinski M, Autilio-Gambetti L, Gambetti P. Role of amyloid precursor protein (APP): study with antisense transfection of human neuroblastoma cells. J Neurosci Res. 1992 Apr; 31(4):635-45. PMID: 1578514.
    Citations: 17     Fields:    Translation:HumansCells
  57. Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T, et al. Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. Adv Neurol. 1990; 51:181-4. PMID: 2104687.
    Citations: 1     Fields:    Translation:HumansCells
  58. Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T, et al. The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives. Prog Clin Biol Res. 1989; 317:971-84. PMID: 2513588.
    Citations: 5     Fields:    Translation:Humans
  59. Autilio-Gambetti L, Morandi A, Kovacs DM, Tabaton M, Schaetzle B, Hauer C, Groger RK, Tykocinski ML, Perry G, Greenberg BD, et al. Amyloid precursor protein in cell cultures: a 130 kDa polypeptide. Prog Clin Biol Res. 1989; 317:985-90. PMID: 2574879.
    Citations:    Fields:    Translation:HumansCells
  60. Autilio-Gambetti L, Morandi A, Tabaton M, Schaetzle B, Kovacs D, Perry G, Sharma S, Cornette J, Greenberg B, Gambetti P. The amyloid percursor protein of Alzheimer disease is expressed as a 130 kDa polypeptide in various cultured cell types. FEBS Lett. 1988 Dec 05; 241(1-2):94-8. PMID: 2904381.
    Citations: 3     Fields:    Translation:HumansCells
  61. Palmert MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Usiak MF, Younkin LH, Younkin SG. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science. 1988 Aug 26; 241(4869):1080-4. PMID: 2457949.
    Citations: 36     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.