Harvard Catalyst Profiles

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Huabiao Chen, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li B, Li G, Yan X, Zhu D, Lin PP, Wang Z, Qu H, He X, Fu Y, Zhu X, Lin P, Zhang J, Li X, Dai H, Chen H, Poznansky MC, Lin N, Ye Z. Fresh Tissue Multi-omics Profiling Reveals Immune Classification and Suggests Immunotherapy Candidates for Conventional Chondrosarcoma. Clin Cancer Res. 2021 12 01; 27(23):6543-6558. PMID: 34426437.
    Citations: 2     Fields:    
  2. Han S, Zhu T, Ding S, Wen J, Lin Z, Lu G, Zhang Y, Xiao W, Ding Y, Jia X, Chen H, Gong W. Early growth response genes 2 and 3 induced by AP-1 and NF-?B modulate TGF-ß1 transcription in NK1.1- CD4+ NKG2D+ T cells. Cell Signal. 2020 12; 76:109800. PMID: 33011290.
    Citations: 2     Fields:    Translation:AnimalsCells
  3. Zhang J, Zhang J, Zhang N, Li T, Zhou X, Jia J, Liang Y, Sun X, Chen H. The Effects of Platelet-Rich and Platelet-Poor Plasma on Biological Characteristics of BM-MSCs In Vitro. Anal Cell Pathol (Amst). 2020; 2020:8546231. PMID: 32908815.
    Citations: 4     Fields:    Translation:AnimalsCells
  4. Chen Z, Wang X, Yang X, Xu Y, Yang Y, Wang H, Li T, Bai P, Yuan G, Chen H, Yang J, Fiedler SA, Striar R, Bernales DR, Koegel RE, Cao Q, Ran C, Xiang B, Li H, Wang C. Imaging assisted evaluation of antitumor efficacy of a new histone deacetylase inhibitor in the castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging. 2021 01; 48(1):53-66. PMID: 32592040.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Wang J, Tannous BA, Poznansky MC, Chen H. CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent. Pharmacol Res. 2020 09; 159:105010. PMID: 32544428.
    Citations: 15     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  6. Li T, Zhou X, Wang J, Liu Z, Han S, Wan L, Sun X, Chen H. Adipose-derived mesenchymal stem cells and extracellular vesicles confer antitumor activity in preclinical treatment of breast cancer. Pharmacol Res. 2020 07; 157:104843. PMID: 32360582.
    Citations: 10     Fields:    Translation:AnimalsCells
  7. Zeng Y, Li B, Li T, Liu W, Ran C, Penson RT, Poznansky MC, Du Y, Chen H. CD90low MSCs modulate intratumoral immunity to confer antitumor activity in a mouse model of ovarian cancer. Oncotarget. 2019 Jul 09; 10(43):4479-4491. PMID: 31320999.
    Citations: 2     Fields:    
  8. Zhou X, Li T, Chen Y, Zhang N, Wang P, Liang Y, Long M, Liu H, Mao J, Liu Q, Sun X, Chen H. Mesenchymal stem cell-derived extracellular vesicles promote the in vitro proliferation and migration of breast cancer cells through the activation of the ERK pathway. Int J Oncol. 2019 May; 54(5):1843-1852. PMID: 30864702.
    Citations: 23     Fields:    Translation:HumansCells
  9. Zeng Y, Li B, Liang Y, Reeves PM, Qu X, Ran C, Liu Q, Callahan MV, Sluder AE, Gelfand JA, Chen H, Poznansky MC. Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment. FASEB J. 2019 05; 33(5):6596-6608. PMID: 30802149.
    Citations: 44     Fields:    Translation:AnimalsCells
  10. Li B, Wang Z, Wu H, Xue M, Lin P, Wang S, Lin N, Huang X, Pan W, Liu M, Yan X, Qu H, Sun L, Li H, Wu Y, Teng W, Wang Z, Zhou X, Chen H, Poznansky MC, Ye Z. Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma. Cancer Res. 2018 07 15; 78(14):3938-3953. PMID: 29735547.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  11. Li B, Zeng Y, Reeves PM, Ran C, Liu Q, Qu X, Liang Y, Liu Z, Yuan J, Leblanc PR, Ye Z, Sluder AE, Gelfand JA, Brauns TA, Chen H, Poznansky MC. AMD3100 Augments the Efficacy of Mesothelin-Targeted, Immune-Activating VIC-008 in Mesothelioma by Modulating Intratumoral Immunosuppression. Cancer Immunol Res. 2018 05; 6(5):539-551. PMID: 29511032.
    Citations: 16     Fields:    Translation:AnimalsCells
  12. Joglekar AV, Liu Z, Weber JK, Ouyang Y, Jeppson JD, Noh WJ, Lamothe-Molina PA, Chen H, Kang SG, Bethune MT, Zhou R, Walker BD, Baltimore D. T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1877-1882. PMID: 29437954.
    Citations: 9     Fields:    Translation:HumansCells
  13. Sun W, Shi J, Wu J, Zhang J, Chen H, Li Y, Liu S, Wu Y, Tian Z, Cao X, Li N. A modified HLA-A*0201-restricted CTL epitope from human oncoprotein (hPEBP4) induces more efficient antitumor responses. Cell Mol Immunol. 2018 08; 15(8):768-781. PMID: 29375131.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  14. Zhang J, Zhang J, Li T, Zhang N, Tang S, Tao Z, Zhou X, Sun X, Chen H. Effect of idebenone on bone marrow mesenchymal stem cells in vitro. Mol Med Rep. 2018 04; 17(4):5376-5383. PMID: 29393352.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Li T, Zhang J, Zhang J, Zhang N, Zeng Y, Tang S, Tao Z, Qu X, Jia J, Zhu W, Sun X, Chen H. Nicotine-enhanced stemness and epithelial-mesenchymal transition of human umbilical cord mesenchymal stem cells promote tumor formation and growth in nude mice. Oncotarget. 2018 Jan 02; 9(1):591-606. PMID: 29416638.
    Citations: 5     Fields:    
  16. Leitman EM, Willberg CB, Tsai MH, Chen H, Buus S, Chen F, Riddell L, Haas D, Fellay J, Goedert JJ, Piechocka-Trocha A, Walker BD, Martin J, Deeks S, Wolinsky SM, Martinson J, Martin M, Qi Y, Sáez-Cirión A, Yang OO, Matthews PC, Carrington M, Goulder PJR. HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection. J Virol. 2017 11 15; 91(22). PMID: 28878089.
    Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
  17. Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, Pai SI. PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs. Cancer Res. 2017 11 15; 77(22):6365-6374. PMID: 28947422.
    Citations: 37     Fields:    Translation:HumansCells
  18. Tu T, Zhan J, Mou D, Li W, Su B, Zhang T, Li T, Li N, Wu H, Jin C, Chen H. In vitro inhibition of HIV-1 replication in autologous CD4+ T cells indicates viral containment by multifactorial mechanisms. Virol Sin. 2017 Dec; 32(6):485-494. PMID: 28918477.
    Citations: 1     Fields:    Translation:HumansCells
  19. Morse K, Kimizuka Y, Chan MPK, Shibata M, Shimaoka Y, Takeuchi S, Forbes B, Nirschl C, Li B, Zeng Y, Bronson RT, Katagiri W, Shigeta A, Sîrbulescu RF, Chen H, Tan RYY, Tsukada K, Brauns T, Gelfand J, Sluder A, Locascio JJ, Poznansky MC, Anandasabapathy N, Kashiwagi S. Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine. J Immunol. 2017 08 15; 199(4):1319-1332. PMID: 28710250.
    Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
  20. Ding Y, Zhang C, Zhang J, Zhang N, Li T, Fang J, Zhang Y, Zuo F, Tao Z, Tang S, Zhu W, Chen H, Sun X. miR-145 inhibits proliferation and migration of breast cancer cells by directly or indirectly regulating TGF-ß1 expression. Int J Oncol. 2017 May; 50(5):1701-1710. PMID: 28393176.
    Citations: 29     Fields:    Translation:HumansCells
  21. Kimizuka Y, Callahan JJ, Huang Z, Morse K, Katagiri W, Shigeta A, Bronson R, Takeuchi S, Shimaoka Y, Chan MPK, Zeng Y, Li B, Chen H, Tan RYY, Dwyer C, Mulley T, Leblanc P, Goudie C, Gelfand J, Tsukada K, Brauns T, Poznansky MC, Bean D, Kashiwagi S. Semiconductor diode laser device adjuvanting intradermal vaccine. Vaccine. 2017 04 25; 35(18):2404-2412. PMID: 28365253.
    Citations: 9     Fields:    Translation:AnimalsPHPublic Health
  22. Flerin NC, Chen H, Glover TD, Lamothe PA, Zheng JH, Fang JW, Ndhlovu ZM, Newell EW, Davis MM, Walker BD, Goldstein H. T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone. J Virol. 2017 03 15; 91(6). PMID: 28077649.
    Citations: 6     Fields:    Translation:HumansCells
  23. Zhu L, Fan X, Wang B, Liu L, Yan X, Zhou L, Zeng Y, Poznansky MC, Wang L, Chen H, Du Y. Biomechanically primed liver microtumor array as a high-throughput mechanopharmacological screening platform for stroma-reprogrammed combinatorial therapy. Biomaterials. 2017 04; 124:12-24. PMID: 28182873.
    Citations: 11     Fields:    Translation:HumansCells
  24. Jin C, Tu T, Mou D, Li Q, Song X, Zhang H, Tang T, Li T, Wu H, Chen H. [Functional Analyses of HIV-1 Specific Cytotoxic T Lymphocyte Clones]. Bing Du Xue Bao. 2016 05; 32(3):331-41. PMID: 29963819.
    Citations:    Fields:    Translation:HumansCells
  25. Zhang C, Liu K, Li T, Fang J, Ding Y, Sun L, Tu T, Jiang X, Du S, Hu J, Zhu W, Chen H, Sun X. miR-21: A gene of dual regulation in breast cancer. Int J Oncol. 2016 Jan; 48(1):161-72. PMID: 26549725.
    Citations: 18     Fields:    Translation:HumansCells
  26. Ndhlovu ZM, Stampouloglou E, Cesa K, Mavrothalassitis O, Alvino DM, Li JZ, Wilton S, Karel D, Piechocka-Trocha A, Chen H, Pereyra F, Walker BD. The Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite Controllers. J Virol. 2015 Nov; 89(21):10735-47. PMID: 26269189.
    Citations: 21     Fields:    Translation:HumansCells
  27. Li T, Zhang C, Ding Y, Zhai W, Liu K, Bu F, Tu T, Sun L, Zhu W, Zhou F, Qi W, Hu J, Chen H, Sun X. Umbilical cord-derived mesenchymal stem cells promote proliferation and migration in MCF-7 and MDA-MB-231 breast cancer cells through activation of the ERK pathway. Oncol Rep. 2015 Sep; 34(3):1469-77. PMID: 26151310.
    Citations: 20     Fields:    Translation:HumansCells
  28. Liu K, Zhang C, Li T, Ding Y, Tu T, Zhou F, Qi W, Chen H, Sun X. Let-7a inhibits growth and migration of breast cancer cells by targeting HMGA1. Int J Oncol. 2015; 46(6):2526-34. PMID: 25846193.
    Citations: 34     Fields:    Translation:HumansCells
  29. Liu D, Chen H. Structured illumination microscopy improves visualization of lytic granules in HIV-1 specific cytotoxic T-lymphocyte immunological synapses. AIDS Res Hum Retroviruses. 2015 Sep; 31(9):866-7. PMID: 25831465.
    Citations: 1     Fields:    Translation:HumansCells
  30. Zhu X, Liu S, Wang P, Qu X, Wang X, Zeng H, Chen H, Zhu H. Oxaliplatin antagonizes HIV-1 latency by activating NF-?B without causing global T cell activation. Biochem Biophys Res Commun. 2014 Jul 18; 450(1):202-7. PMID: 24878527.
    Citations: 1     Fields:    Translation:HumansCells
  31. Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin NH, Nguyen M, Jean-Mary G, Tong X, Uppal P, Korochkina S, Forbes B, Chen T, Righi E, Bronson R, Chen H, Orsulic S, Brauns T, Leblanc P, Scholler N, Dranoff G, Gelfand J, Poznansky MC. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. J Hematol Oncol. 2014 Feb 24; 7:15. PMID: 24565018.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  32. Foley MH, Forcier T, McAndrew E, Gonzalez M, Chen H, Juelg B, Walker BD, Irvine DJ. High avidity CD8+ T cells efficiently eliminate motile HIV-infected targets and execute a locally focused program of anti-viral function. PLoS One. 2014; 9(2):e87873. PMID: 24551068.
    Citations: 19     Fields:    Translation:HumansCells
  33. Xia Z, Chen H, Kang SG, Huynh T, Fang JW, Lamothe PA, Walker BD, Zhou R. The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function. Sci Rep. 2014 Feb 13; 4:4087. PMID: 24522437.
    Citations: 10     Fields:    Translation:Cells
  34. Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, Pereyra F, Yu XG, Douek DC, Kaufmann DE, Allen TM, Walker BD. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nat Immunol. 2012 Jun 10; 13(7):691-700. PMID: 22683743.
    Citations: 129     Fields:    Translation:HumansCells
  35. Zhang SC, Martin E, Shimada M, Godfrey SB, Fricke J, Locastro S, Lai NY, Liebesny P, Carlson JM, Brumme CJ, Ogbechie OA, Chen H, Walker BD, Brumme ZL, Kavanagh DG, Le Gall S. Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals. J Immunol. 2012 Jun 15; 188(12):5924-34. PMID: 22586036.
    Citations: 25     Fields:    Translation:Humans
  36. Varadarajan N, Julg B, Yamanaka YJ, Chen H, Ogunniyi AO, McAndrew E, Porter LC, Piechocka-Trocha A, Hill BJ, Douek DC, Pereyra F, Walker BD, Love JC. A high-throughput single-cell analysis of human CD8? T cell functions reveals discordance for cytokine secretion and cytolysis. J Clin Invest. 2011 Nov; 121(11):4322-31. PMID: 21965332.
    Citations: 75     Fields:    Translation:HumansCells
  37. Chen H, Li C, Huang J, Cung T, Seiss K, Beamon J, Carrington MF, Porter LC, Burke PS, Yang Y, Ryan BJ, Liu R, Weiss RH, Pereyra F, Cress WD, Brass AL, Rosenberg ES, Walker BD, Yu XG, Lichterfeld M. CD4+ T cells from elite controllers resist HIV-1 infection by selective upregulation of p21. J Clin Invest. 2011 Apr; 121(4):1549-60. PMID: 21403397.
    Citations: 104     Fields:    Translation:HumansCells
  38. Yuan J, Li P, Tao J, Shi X, Hu B, Chen H, Guo X. H. pylori escape host immunoreaction through inhibiting ILK expression by VacA. Cell Mol Immunol. 2009 Jun; 6(3):191-7. PMID: 19567202.
    Citations: 7     Fields:    Translation:HumansCells
  39. Chen H, Piechocka-Trocha A, Miura T, Brockman MA, Julg BD, Baker BM, Rothchild AC, Block BL, Schneidewind A, Koibuchi T, Pereyra F, Allen TM, Walker BD. Differential neutralization of human immunodeficiency virus (HIV) replication in autologous CD4 T cells by HIV-specific cytotoxic T lymphocytes. J Virol. 2009 Apr; 83(7):3138-49. PMID: 19158248.
    Citations: 60     Fields:    Translation:HumansCells
  40. Schneidewind A, Brockman MA, Sidney J, Wang YE, Chen H, Suscovich TJ, Li B, Adam RI, Allgaier RL, Mothé BR, Kuntzen T, Oniangue-Ndza C, Trocha A, Yu XG, Brander C, Sette A, Walker BD, Allen TM. Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid. J Virol. 2008 Jun; 82(11):5594-605. PMID: 18385228.
    Citations: 97     Fields:    Translation:HumansCells
  41. Chen H, Hou J, Jiang X, Ma S, Meng M, Wang B, Zhang M, Zhang M, Tang X, Zhang F, Wan T, Li N, Yu Y, Hu H, Yang R, He W, Wang X, Cao X. Response of memory CD8+ T cells to severe acute respiratory syndrome (SARS) coronavirus in recovered SARS patients and healthy individuals. J Immunol. 2005 Jul 01; 175(1):591-8. PMID: 15972696.
    Citations: 51     Fields:    Translation:HumansCells
  42. Yuan JP, Li T, Chen HB, Li ZH, Yang GZ, Hu BY, Shi XD, Tong SQ, Li YX, Guo XK. Analysis of gene expression profile in gastric cancer cells stimulated with Helicobacter pylori isogenic strains. J Med Microbiol. 2004 Oct; 53(Pt 10):965-974. PMID: 15358818.
    Citations: 5     Fields:    Translation:HumansCells
  43. Wang B, Chen H, Jiang X, Zhang M, Wan T, Li N, Zhou X, Wu Y, Yang F, Yu Y, Wang X, Yang R, Cao X. Identification of an HLA-A*0201-restricted CD8+ T-cell epitope SSp-1 of SARS-CoV spike protein. Blood. 2004 Jul 01; 104(1):200-6. PMID: 15016646.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  44. Chen HB, Fang DX, Li FQ, Jing HY, Tan WG, Li SQ. A novel hepatitis B virus mutant with A-to-G at nt551 in the surface antigen gene. World J Gastroenterol. 2003 Feb; 9(2):304-8. PMID: 12532454.
    Citations: 6     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.