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Cammie Lesser, M.D., Ph.D.


Drag'nDrop into Viral Inclusions: A Novel Visualization Platform for Detecting Protein Interactions
Summer, 06/11/07 - 08/10/07

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI144716 (LESSER, CAMMIE) Feb 1, 2020 - Jan 31, 2022
    Designer probiotics for prevention of cholera
    Role: Principal Investigator
  2. R01AI128360 (LESSER, CAMMIE) Feb 1, 2019 - Jan 31, 2024
    Dissecting the means by which type 3 substrates are defined & secreted
    Role: Principal Investigator
  3. R21AI128743 (LESSER, CAMMIE) Jun 26, 2017 - Nov 30, 2019
    Shigella and macrophage cell death
    Role: Principal Investigator
  4. R01DK113599 (LESSER, CAMMIE) Sep 23, 2016 - Aug 31, 2021
    Designer Probiotics for the treatment of intestinal infection and inflammation
    Role: Co-Principal Investigator
  5. R21AI113949 (LESSER, CAMMIE) Jun 11, 2014 - May 31, 2017
    PIPs: a new means to identify effector-target interactions
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wood TE, Westervelt KA, Yoon JM, Eshleman HD, Levy R, Burnes H, Slade DJ, Lesser CF, Goldberg MB. The Shigella Spp. Type III Effector Protein OspB Is a Cysteine Protease. mBio. 2022 06 28; 13(3):e0127022. PMID: 35638611; PMCID: PMC9239218.
    Citations:    Fields:    Translation:AnimalsCells
  2. Alphonse N, Wanford JJ, Voak AA, Gay J, Venkhaya S, Burroughs O, Mathew S, Lee T, Evans SL, Zhao W, Frowde K, Alrehaili A, Dickenson RE, Munk M, Panina S, Mahmood IF, Llorian M, Stanifer ML, Boulant S, Berchtold MW, Bergeron JRC, Wack A, Lesser CF, Odendall C. A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling. Cell. 2022 06 23; 185(13):2354-2369.e17. PMID: 35568036.
    Citations:    Fields:    Translation:AnimalsCells
  3. Lynch JP, Goers L, Lesser CF. Emerging strategies for engineering Escherichia coli Nissle 1917-based therapeutics. Trends Pharmacol Sci. 2022 Sep; 43(9):772-786. PMID: 35232591; PMCID: PMC9378478.
    Citations: 2     Fields:    
  4. Kutsch M, González-Prieto C, Lesser CF, Coers J. The GBP1 microcapsule interferes with IcsA-dependent septin cage assembly around Shigella flexneri. Pathog Dis. 2021 04 24; 79(5). PMID: 33885766; PMCID: PMC8068759.
    Citations: 1     Fields:    Translation:HumansCells
  5. Lynch JP, Lesser CF. A host metabolite promotes Salmonella survival. Science. 2021 01 22; 371(6527):344-345. PMID: 33479138.
    Citations: 1     Fields:    Translation:Cells
  6. Mitchell PS, Roncaioli JL, Turcotte EA, Goers L, Chavez RA, Lee AY, Lesser CF, Rauch I, Vance RE. NAIP-NLRC4-deficient mice are susceptible to shigellosis. Elife. 2020 10 19; 9. PMID: 33074100.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  7. Kutsch M, Sistemich L, Lesser CF, Goldberg MB, Herrmann C, Coers J. Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions. EMBO J. 2020 07 01; 39(13):e104926. PMID: 32510692; PMCID: PMC7327485.
    Citations: 39     Fields:    Translation:HumansCells
  8. Sandstrom A, Mitchell PS, Goers L, Mu EW, Lesser CF, Vance RE. Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes. Science. 2019 04 05; 364(6435). PMID: 30872533; PMCID: PMC6532986.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  9. Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C, Lencer WI. INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. Elife. 2018 10 25; 7. PMID: 30355448.
    Citations: 7     Fields:    Translation:HumansCells
  10. Lynch JP, Lesser CF. Host-Pathogen Interactions: What the EHEC Are We Learning from Host Genome-Wide Screens? mBio. 2018 10 09; 9(5). PMID: 30301858.
    Citations:    Fields:    Translation:Cells
  11. Ernst NH, Reeves AZ, Ramseyer JE, Lesser CF. High-Throughput Screening of Type III Secretion Determinants Reveals a Major Chaperone-Independent Pathway. mBio. 2018 06 19; 9(3). PMID: 29921672.
    Citations: 5     Fields:    Translation:Cells
  12. Mou X, Souter S, Du J, Reeves AZ, Lesser CF. Synthetic bottom-up approach reveals the complex interplay of Shigella effectors in regulation of epithelial cell death. Proc Natl Acad Sci U S A. 2018 06 19; 115(25):6452-6457. PMID: 29866849; PMCID: PMC6016774.
    Citations: 9     Fields:    Translation:HumansCells
  13. Piro AS, Hernandez D, Luoma S, Feeley EM, Finethy R, Yirga A, Frickel EM, Lesser CF, Coers J. Detection of Cytosolic Shigella flexneri via a C-Terminal Triple-Arginine Motif of GBP1 Inhibits Actin-Based Motility. mBio. 2017 12 12; 8(6). PMID: 29233899.
    Citations: 41     Fields:    Translation:HumansCells
  14. González-Prieto C, Lesser CF. Rationale redesign of type III secretion systems: toward the development of non-pathogenic E. coli for in vivo delivery of therapeutic payloads. Curr Opin Microbiol. 2018 02; 41:1-7. PMID: 29141238; PMCID: PMC5862735.
    Citations: 5     Fields:    Translation:Cells
  15. Rooks MG, Veiga P, Reeves AZ, Lavoie S, Yasuda K, Asano Y, Yoshihara K, Michaud M, Wardwell-Scott L, Gallini CA, Glickman JN, Sudo N, Huttenhower C, Lesser CF, Garrett WS. QseC inhibition as an antivirulence approach for colitis-associated bacteria. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):142-147. PMID: 27980034; PMCID: PMC5224399.
    Citations: 21     Fields:    Translation:AnimalsCells
  16. Reeves AZ, Lesser CF. Transfer of Large Contiguous DNA Fragments onto a Low Copy Plasmid or into the Bacterial Chromosome. Bio Protoc. 2016 Nov 20; 6(22). PMID: 28203614; PMCID: PMC5304469.
    Citations: 2     
  17. Janakiraman A, Lesser CF. How to manage stress: Lessons from an intracellular pathogen. Virulence. 2017 05 19; 8(4):359-361. PMID: 27808599; PMCID: PMC5477710.
    Citations: 4     Fields:    Translation:HumansCells
  18. Sheehan KB, Martin M, Lesser CF, Isberg RR, Newton IL. Identification and Characterization of a Candidate Wolbachia pipientis Type IV Effector That Interacts with the Actin Cytoskeleton. mBio. 2016 07 05; 7(4). PMID: 27381293; PMCID: PMC4958246.
    Citations: 23     Fields:    Translation:AnimalsCells
  19. Du J, Reeves AZ, Klein JA, Twedt DJ, Knodler LA, Lesser CF. The type III secretion system apparatus determines the intracellular niche of bacterial pathogens. Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17):4794-9. PMID: 27078095; PMCID: PMC4855615.
    Citations: 38     Fields:    Translation:HumansCells
  20. Reeves AZ, Spears WE, Du J, Tan KY, Wagers AJ, Lesser CF. Engineering Escherichia coli into a protein delivery system for mammalian cells. ACS Synth Biol. 2015 May 15; 4(5):644-54. PMID: 25853840.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  21. Costa SC, Lesser CF. A multifunctional region of the Shigella type 3 effector IpgB1 is important for secretion from bacteria and membrane targeting in eukaryotic cells. PLoS One. 2014; 9(4):e93461. PMID: 24718571.
    Citations: 6     Fields:    Translation:AnimalsCells
  22. Costa SC, Schmitz AM, Jahufar FF, Boyd JD, Cho MY, Glicksman MA, Lesser CF. A new means to identify type 3 secreted effectors: functionally interchangeable class IB chaperones recognize a conserved sequence. mBio. 2012; 3(1). PMID: 22334517.
    Citations: 23     Fields:    Translation:HumansCells
  23. de Groot JC, Schlüter K, Carius Y, Quedenau C, Vingadassalom D, Faix J, Weiss SM, Reichelt J, Standfuss-Gabisch C, Lesser CF, Leong JM, Heinz DW, Büssow K, Stradal TE. Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli. Structure. 2011 Sep 07; 19(9):1294-306. PMID: 21893288.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  24. Archuleta TL, Du Y, English CA, Lory S, Lesser C, Ohi MD, Ohi R, Spiller BW. The Chlamydia effector chlamydial outer protein N (CopN) sequesters tubulin and prevents microtubule assembly. J Biol Chem. 2011 Sep 30; 286(39):33992-8. PMID: 21841198.
    Citations: 27     Fields:    Translation:AnimalsCells
  25. Lesser CF, Leong JM. Bacterial scaffolds assemble novel higher-order complexes to reengineer eukaryotic cell processes. Sci Signal. 2011 Jul 05; 4(180):pe32. PMID: 21730324.
    Citations: 1     Fields:    Translation:Cells
  26. Durand-Heredia JM, Yu HH, De Carlo S, Lesser CF, Janakiraman A. Identification and characterization of ZapC, a stabilizer of the FtsZ ring in Escherichia coli. J Bacteriol. 2011 Mar; 193(6):1405-13. PMID: 21216995.
    Citations: 47     Fields:    Translation:Cells
  27. Sukumaran B, Mastronunzio JE, Narasimhan S, Fankhauser S, Uchil PD, Levy R, Graham M, Colpitts TM, Lesser CF, Fikrig E. Anaplasma phagocytophilum AptA modulates Erk1/2 signalling. Cell Microbiol. 2011 Jan; 13(1):47-61. PMID: 20716207.
    Citations: 24     Fields:    Translation:HumansCells
  28. McCoy MW, Marré ML, Lesser CF, Mecsas J. The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence. Infect Immun. 2010 Jun; 78(6):2584-98. PMID: 20368345.
    Citations: 35     Fields:    Translation:AnimalsCells
  29. Heindl JE, Saran I, Yi CR, Lesser CF, Goldberg MB. Requirement for formin-induced actin polymerization during spread of Shigella flexneri. Infect Immun. 2010 Jan; 78(1):193-203. PMID: 19841078.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  30. Schmitz AM, Morrison MF, Agunwamba AO, Nibert ML, Lesser CF. Protein interaction platforms: visualization of interacting proteins in yeast. Nat Methods. 2009 Jul; 6(7):500-2. PMID: 19483691.
    Citations: 21     Fields:    Translation:AnimalsCells
  31. Siggers, K.A. and Lesser, C.F. Shigella IpgB1, a RhoGTPase mimic, localizes to lipid rafts in both yeast and mammalian cells. Cellular Microbiology. 2008; in review.
  32. Fukazawa, A., Alsono, C., Kurachi, K. Gupta, S., Lesser, C., McCormick, B.A. and Reinecker, H-C. . GEF-H1 Mediated Control of NOD1 Dependent NF-κB Activation by Shigella Effectors. PLoS Pathogens, in press. 2008.
  33. Fukazawa A, Alonso C, Kurachi K, Gupta S, Lesser CF, McCormick BA, Reinecker HC. GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors. PLoS Pathog. 2008 Nov; 4(11):e1000228. PMID: 19043560.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  34. Huang, J., Lesser, C.F., and Lory, S. . The essential role of the CopN protein for Chlamydia pneumoniae intracellular growth. 10.1038/nature07355. 2008.
  35. Huang J, Lesser CF, Lory S. The essential role of the CopN protein in Chlamydia pneumoniae intracellular growth. Nature. 2008 Nov 06; 456(7218):112-5. PMID: 18830244.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  36. Siggers KA, Lesser CF. The Yeast Saccharomyces cerevisiae: a versatile model system for the identification and characterization of bacterial virulence proteins. Cell Host Microbe. 2008 Jul 17; 4(1):8-15. PMID: 18621006.
    Citations: 50     Fields:    Translation:Animals
  37. Siggers, K.A and Lesser, C.F. . The Yeast Saccharoyces cerevisiae: A versatile Model System for the Identification and Characterization of Bacterial Virulence Proteins. Cell, Host and Microbe. 2008; 4(1):8-15.
  38. Slagowski NL, Kramer RW, Morrison MF, LaBaer J, Lesser CF. A functional genomic yeast screen to identify pathogenic bacterial proteins. PLoS Pathog. 2008 Jan; 4(1):e9. PMID: 18208325.
    Citations: 41     Fields:    Translation:AnimalsCells
  39. Slagowski, N.L., Kramer, R.W., Morrison, M.F., LaBaer and Lesser, CF . A functional genomic yeast screen to identify pathogenic bacterial proteins. 2008; 4(1):e9.
  40. Kramer RW, Slagowski NL, Eze NA, Giddings KS, Morrison MF, Siggers KA, Starnbach MN, Lesser CF. Yeast functional genomic screens lead to identification of a role for a bacterial effector in innate immunity regulation. PLoS Pathog. 2007 Feb; 3(2):e21. PMID: 17305427; PMCID: PMC1797620.
    Citations: 41     Fields:    Translation:AnimalsCells
  41. Lesser CF, Miller SI. . Salmonellosis. Harrison's Principles of Internal Medicine. 2004.
  42. Gottlieb GS, Lesser CF, Holmes KK, Wald A. Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-alpha antagonists. Clin Infect Dis. 2003 Sep 15; 37(6):838-40. PMID: 12955647.
    Citations: 15     Fields:    Translation:Humans
  43. Gottlieb, G.S., Lesser, C.F., Holmes K.K. and Wald, A. . Disseminated Sporotrichosis associated with treatment with immunosuppressants and TNF alpha antagonists. CID. 2003; 37(6):838-40.
  44. Shone SM, Ferrao PN, Lesser CR, Norris DE, Glass GE. Analysis of mosquito vector species abundances in Maryland using geographic information systems. Ann N Y Acad Sci. 2001 Dec; 951:364-8. PMID: 11797801.
    Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
  45. Lesser CF, Miller SI. Expression of microbial virulence proteins in Saccharomyces cerevisiae models mammalian infection. EMBO J. 2001 Apr 17; 20(8):1840-9. PMID: 11296218; PMCID: PMC125424.
    Citations: 44     Fields:    Translation:AnimalsCells
  46. Lesser CF, Miller SI. . Salmonellosis. Harrison's Principles of Internal Medicine. 2001; 975-8.
  47. Lesser, C.F. and Miller, S.I. . Tractable Saccharomyces cerevisiae is model system for studying pathogenic bacterial proteins: introducing bacterial virulence proteins into yeast provides valuable insights about their interactions with host components. ASM News. 2001; 67(9):448-455.
  48. Lesser, C.F. and Miller, S.I. . Expression of microbial virulence factors in Saccharomyces cerevisiae models mammalian infection. . EMBO Journal. 2001; 20(8):1840-9.
  49. Lesser CF, Scherer CA, Miller SI. Rac, ruffle and rho: orchestration of Salmonella invasion. Trends Microbiol. 2000 Apr; 8(4):151-2. PMID: 10754568.
    Citations: 1     Fields:    Translation:AnimalsCells
  50. Lesser, C.F., Scherer, C.A and Miller, S.I. . Rac, Ruffle and Rho: Orchestration of Salmonella ruffling. Trends in Microbiology. 2000; 8(4):151-2.
  51. Lesser CF, Guthrie C. Mutations in U6 snRNA that alter splice site specificity: implications for the active site. Science. 1993 Dec 24; 262(5142):1982-8. PMID: 8266093.
    Citations: 146     Fields:    Translation:AnimalsCells
  52. Lesser CF, Guthrie C. Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1. Genetics. 1993 Apr; 133(4):851-63. PMID: 8462846.
    Citations: 101     Fields:    Translation:AnimalsCells
  53. Andrews DW, Perara E, Lesser C, Lingappa VR. Sequences beyond the cleavage site influence signal peptide function. J Biol Chem. 1988 Oct 25; 263(30):15791-8. PMID: 3170612.
    Citations: 17     Fields:    Translation:AnimalsCells
  54. Leong JM, Nunes-Düby SE, Oser AB, Lesser CF, Youderian P, Susskind MM, Landy A. Structural and regulatory divergence among site-specific recombination genes of lambdoid phage. J Mol Biol. 1986 Jun 20; 189(4):603-16. PMID: 3491212.
    Citations: 33     Fields:    Translation:Cells
  55. Leong JM, Nunes-Düby S, Lesser CF, Youderian P, Susskind MM, Landy A. The phi 80 and P22 attachment sites. Primary structure and interaction with Escherichia coli integration host factor. J Biol Chem. 1985 Apr 10; 260(7):4468-77. PMID: 2984205.
    Citations: 81     Fields:    Translation:Cells
  56. Leong, J.M., Nunes-Duby, S., Lesser, C.F., Youderin, P., Susskind, M.M. and Landy, A. . The Ø80 and P22 attachment sites. Primary structure and interaction with Escherichia coli integration host factor. Journal of Biological Chemistry. 1985; 260(7):4468-77.
  57. Leong JM, Nunes-Duby S, Oser A, Lesser CF, Youderian P, Susskind MM, Landy A. Site-specific recombination systems of phages phi 80 and P22: binding sites of integration host factor and recombination-induced mutations. Cold Spring Harb Symp Quant Biol. 1984; 49:707-14. PMID: 6597762.
    Citations: 3     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.