Harvard Catalyst Profiles

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Jorge Plutzky, M.D.



The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK107239 (PLUTZKY, JORGE) Aug 21, 2017 - Jun 30, 2022
    ALDH1a1 Inhibition As A Therapeutic Target In Visceral Adiposity and Type 2 Diabetes
    Role: Principal Investigator
  2. R56HL125894 (PLUTZKY, JORGE) Sep 8, 2015 - Aug 31, 2017
    Epigenetic Control of Endothelial and T Cell States By BET Reader Proteins
    Role: Principal Investigator
  3. R01HL079117 (PLUTZKY, JORGE) Jan 1, 2005 - Dec 31, 2005
    Endogenous Mechanisms of PPAR Modulation
    Role: Principal Investigator
  4. R01HL071745 (PLUTZKY, JORGE) Jan 1, 2004 - Dec 31, 2009
    Lipolytic Mechanisms of PPAR Activation
    Role: Principal Investigator
  5. K08HL003107 (PLUTZKY, JORGE) Jul 1, 1994 - Jun 30, 1999
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Blood AJ, Cannon CP, Gordon WJ, Mailly C, MacLean T, Subramaniam S, Tucci M, Crossen J, Nichols H, Wagholikar KB, Zelle D, McPartlin M, Matta LS, Oates M, Aronson S, Murphy S, Landman A, Fisher NDL, Gaziano TA, Plutzky J, Scirica BM. Results of a Remotely Delivered Hypertension and Lipid Program in More Than 10?000 Patients Across a Diverse Health Care Network. JAMA Cardiol. 2023 Jan 01; 8(1):12-21. PMID: 36350612; PMCID: PMC9647559.
    Citations:    Fields:    Translation:Humans
  2. Lingvay I, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lincoff AM, Marso SP, Fries TM, Plutzky J, Ryan DH. Semaglutide for cardiovascular event reduction in people with overweight or obesity: SELECT study baseline characteristics. Obesity (Silver Spring). 2023 01; 31(1):111-122. PMID: 36502289.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  3. Ventura P, Sardh E, Longo N, Balwani M, Plutzky J, Gouya L, Phillips J, Rhyee S, Fanelli MJ, Sweetser MT, Petrides PE. Hyperhomocysteinemia in acute hepatic porphyria (AHP) and implications for treatment with givosiran. Expert Rev Gastroenterol Hepatol. 2022 Sep; 16(9):879-894. PMID: 35929959.
    Citations: 1     Fields:    Translation:Humans
  4. Weber B, Weisenfeld D, Seyok T, Huang S, Massarotti E, Barrett L, Bibbo C, Solomon DH, Plutzky J, Bolster M, Di Carli M, Liao KP. Relationship Between Risk of Atherosclerotic Cardiovascular Disease, Inflammation, and Coronary Microvascular Dysfunction in Rheumatoid Arthritis. J Am Heart Assoc. 2022 06 07; 11(11):e025467. PMID: 35657008; PMCID: PMC9238711.
    Citations:    Fields:    Translation:Humans
  5. Pilvar A, Plutzky J, Pierce M, Roblyer D. Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties. J Biomed Opt. 2022 06; 27(6). PMID: 35715883; PMCID: PMC9204261.
    Citations:    Fields:    Translation:Humans
  6. Zhuang R, Chen J, Cheng HS, Assa C, Jamaiyar A, Pandey AK, Pérez-Cremades D, Zhang B, Tzani A, Khyrul Wara A, Plutzky J, Barrera V, Bhetariya P, Mitchell RN, Liu Z, Feinberg MW. Perivascular Fibrosis Is Mediated by a KLF10-IL-9 Signaling Axis in CD4+ T Cells. Circ Res. 2022 05 27; 130(11):1662-1681. PMID: 35440172; PMCID: PMC9149118.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Gupta RM, Plutzky J. The Aging Aorta: Are We Only as Old as Our Endothelium? Arterioscler Thromb Vasc Biol. 2022 02; 42(2):172-174. PMID: 35080899; PMCID: PMC9741947.
    Citations:    Fields:    
  8. Wu WY, Biery DW, Berman AN, Hsieh G, Divakaran S, Gupta S, Steigner ML, Aghayev A, Skali H, Polk DM, Plutzky J, Cannon CP, Di Carli MF, Blankstein R. Impact of coronary artery calcium testing on patient management. J Cardiovasc Comput Tomogr. 2022 Jul-Aug; 16(4):303-308. PMID: 34998708; PMCID: PMC9203593.
    Citations:    Fields:    Translation:Humans
  9. Handelsman Y, Anderson JE, Bakris GL, Ballantyne CM, Beckman JA, Bhatt DL, Bloomgarden ZT, Bozkurt B, Budoff MJ, Butler J, Dagogo-Jack S, de Boer IH, DeFronzo RA, Eckel RH, Einhorn D, Fonseca VA, Green JB, Grunberger G, Guerin C, Inzucchi SE, Jellinger PS, Kosiborod MN, Kushner P, Lepor N, Mende CW, Michos ED, Plutzky J, Taub PR, Umpierrez GE, Vaduganathan M, Weir MR. DCRM Multispecialty Practice Recommendations for the management of diabetes, cardiorenal, and metabolic diseases. J Diabetes Complications. 2022 02; 36(2):108101. PMID: 34922811; PMCID: PMC9803322.
    Citations: 1     Fields:    Translation:Humans
  10. Bays HE, Baum SJ, Brinton EA, Plutzky J, Hanselman JC, Teng R, Ballantyne CM. Effect of bempedoic acid plus ezetimibe fixed-dose combination vs ezetimibe or placebo on low-density lipoprotein cholesterol in patients with type 2 diabetes and hypercholesterolemia not treated with statins. Am J Prev Cardiol. 2021 Dec; 8:100278. PMID: 34746903; PMCID: PMC8550983.
    Citations: 2     
  11. Plutzky J, Benson MD, Chaney K, Bui TV, Kraft M, Matta L, McPartlin M, Zelle D, Cannon CP, Dodek A, Gaziano TA, Desai AS, MacRae CA, Scirica BM. Population health management of low-density lipoprotein cholesterol via a remote, algorithmic, navigator-executed program. Am Heart J. 2022 01; 243:15-27. PMID: 34481756.
    Citations:    Fields:    Translation:Humans
  12. Berman AN, Biery DW, Ginder C, Singh A, Baek J, Wadhera RK, Wu WY, Divakaran S, DeFilippis EM, Hainer J, Cannon CP, Plutzky J, Polk DM, Nasir K, Di Carli MF, Ash AS, Bhatt DL, Blankstein R. Association of Socioeconomic Disadvantage With Long-term Mortality After Myocardial Infarction: The Mass General Brigham YOUNG-MI Registry. JAMA Cardiol. 2021 08 01; 6(8):880-888. PMID: 34009238; PMCID: PMC8135064.
    Citations: 3     Fields:    Translation:Humans
  13. Berman AN, Biery DW, Singh A, Wu WY, Divakaran S, DeFilippis EM, Hainer J, Blaha MJ, Cannon C, Polk DM, Plutzky J, Natarajan P, Nasir K, Di Carli MF, Bhatt DL, Blankstein R. Atherosclerotic cardiovascular disease risk and elevated lipoprotein(a) among young adults with myocardial infarction: The Partners YOUNG-MI Registry. Eur J Prev Cardiol. 2021 07 23; 28(8):e12-e14. PMID: 32539451; PMCID: PMC7736085.
    Citations: 2     Fields:    Translation:Humans
  14. Achhra AC, Lyass A, Borowsky L, Bogorodskaya M, Plutzky J, Massaro JM, D'Agostino RB, Triant VA. Assessing Cardiovascular Risk in People Living with HIV: Current Tools and Limitations. Curr HIV/AIDS Rep. 2021 08; 18(4):271-279. PMID: 34247329; PMCID: PMC8733948.
    Citations: 2     Fields:    Translation:Humans
  15. Weber B, He Z, Yang N, Playford MP, Weisenfeld D, Iannaccone C, Coblyn J, Weinblatt M, Shadick N, Di Carli M, Mehta NN, Plutzky J, Liao KP. Divergence of Cardiovascular Biomarkers of Lipids and Subclinical Myocardial Injury Among Rheumatoid Arthritis Patients With Increased Inflammation. Arthritis Rheumatol. 2021 06; 73(6):970-979. PMID: 33615723; PMCID: PMC9707860.
    Citations: 3     Fields:    Translation:Humans
  16. Desai AS, Maclean T, Blood AJ, Bosque-Hamilton J, Dunning J, Fischer C, Fera L, Smith KV, Wagholikar K, Zelle D, Gaziano T, Plutzky J, Scirica B, MacRae CA. Remote Optimization of Guideline-Directed Medical Therapy in Patients With Heart Failure With Reduced Ejection Fraction. JAMA Cardiol. 2020 12 01; 5(12):1430-1434. PMID: 32936209; PMCID: PMC7495335.
    Citations: 10     Fields:    Translation:Humans
  17. Shen H, Li J, Xie X, Yang H, Zhang M, Wang B, Kent KC, Plutzky J, Guo LW. BRD2 regulation of sigma-2 receptor upon cholesterol deprivation. Life Sci Alliance. 2021 01; 4(1). PMID: 33234676; PMCID: PMC7723276.
    Citations: 5     Fields:    Translation:HumansCells
  18. Scirica BM, Cannon CP, Fisher NDL, Gaziano TA, Zelle D, Chaney K, Miller A, Nichols H, Matta L, Gordon WJ, Murphy S, Wagholikar KB, Plutzky J, MacRae CA. Digital Care Transformation: Interim Report From the First 5000 Patients Enrolled in a Remote Algorithm-Based Cardiovascular Risk Management Program to Improve Lipid and Hypertension Control. Circulation. 2021 02 02; 143(5):507-509. PMID: 33201729; PMCID: PMC8103500.
    Citations: 7     Fields:    Translation:Humans
  19. Nicholls S, Lincoff AM, Bays HE, Cho L, Grobbee DE, Kastelein JJ, Libby P, Moriarty PM, Plutzky J, Ray KK, Thompson PD, Sasiela W, Mason D, McCluskey J, Davey D, Wolski K, Nissen SE. Rationale and design of the CLEAR-outcomes trial: Evaluating the effect of bempedoic acid on cardiovascular events in patients with statin intolerance. Am Heart J. 2021 05; 235:104-112. PMID: 33470195.
    Citations: 15     Fields:    Translation:Humans
  20. Honigberg MC, Chang LS, McGuire DK, Plutzky J, Aroda VR, Vaduganathan M. Use of Glucagon-Like Peptide-1 Receptor Agonists in Patients With Type 2 Diabetes and Cardiovascular Disease: A Review. JAMA Cardiol. 2020 10 01; 5(10):1182-1190. PMID: 32584928.
    Citations: 11     Fields:    Translation:Humans
  21. Fenzl A, Kulterer OC, Spirk K, Mitulovic G, Marculescu R, Bilban M, Baumgartner-Parzer S, Kautzky-Willer A, Kenner L, Plutzky J, Quadro L, Kiefer FW. Intact vitamin A transport is critical for cold-mediated adipose tissue browning and thermogenesis. Mol Metab. 2020 12; 42:101088. PMID: 32992038.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  22. Ryan DH, Lingvay I, Colhoun HM, Deanfield J, Emerson SS, Kahn SE, Kushner RF, Marso S, Plutzky J, Brown-Frandsen K, Gronning MOL, Hovingh GK, Holst AG, Ravn H, Lincoff AM. Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) rationale and design. Am Heart J. 2020 11; 229:61-69. PMID: 32916609.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  23. Berman AN, Biery DW, Singh A, Wu WY, Divakaran S, DeFilippis EM, Hainer J, Blaha MJ, Cannon C, Polk DM, Plutzky J, Natarajan P, Nasir K, Di Carli MF, Bhatt DL, Blankstein R. Atherosclerotic cardiovascular disease risk and elevated lipoprotein(a) among young adults with myocardial infarction: The Partners YOUNG-MI Registry. Eur J Prev Cardiol. 2020 Jun 23. PMID: 33611447.
    Citations:    Fields:    
  24. Yang IT, Hemphill LC, Kim JH, Bibangambah P, Sentongo R, Kakuhire B, Plutzky J, Boum Y, Tsai AC, Okello S, Siedner MJ. To fast or not to fast: Lipid measurement and cardiovascular disease risk estimation in rural sub-Saharan Africa. J Glob Health. 2020 Jun; 10(1):010407. PMID: 32257155; PMCID: PMC7101029.
    Citations:    Fields:    Translation:Humans
  25. Plutzky J. Epigenetic Therapeutics for Cardiovascular Disease: Writing, Erasing, Reading, and Maybe Forgetting. JAMA. 2020 04 28; 323(16):1557-1558. PMID: 32219361.
    Citations:    Fields:    Translation:Humans
  26. Borck PC, Guo LW, Plutzky J. BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs. Circ Res. 2020 04 24; 126(9):1190-1208. PMID: 32324495.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  27. Rogers MA, Chen J, Nallamshetty S, Pham T, Goto S, Muehlschlegel JD, Libby P, Aikawa M, Aikawa E, Plutzky J. Retinoids Repress Human Cardiovascular Cell Calcification With Evidence for Distinct Selective Retinoid Modulator Effects. Arterioscler Thromb Vasc Biol. 2020 03; 40(3):656-669. PMID: 31852220; PMCID: PMC7047603.
    Citations: 10     Fields:    Translation:HumansCells
  28. Chang LS, Vaduganathan M, Plutzky J, Aroda VR. Bridging the Gap for Patients with Diabetes and Cardiovascular Disease Through Cardiometabolic Collaboration. Curr Diab Rep. 2019 12 04; 19(12):157. PMID: 31802265.
    Citations: 3     Fields:    Translation:Humans
  29. Divakaran S, Singh A, Biery D, Yang J, DeFilippis EM, Collins BL, Ramsis M, Qamar A, Hainer J, Klein J, Cannon CP, Polk DM, Plutzky J, Nasir K, Januzzi JL, Di Carli MF, Bhatt DL, Blankstein R. Diabetes Is Associated With Worse Long-term Outcomes in Young Adults After Myocardial Infarction: The Partners YOUNG-MI Registry. Diabetes Care. 2020 08; 43(8):1843-1850. PMID: 31548242; PMCID: PMC7372040.
    Citations: 11     Fields:    Translation:Humans
  30. Cosentino F, Ceriello A, Baeres FMM, Fioretto P, Garber A, Stough WG, George JT, Grant PJ, Khunti K, Langkilde AM, Plutzky J, Rydén L, Scheen A, Standl E, Tuomilehto J, Zannad F. Addressing cardiovascular risk in type 2 diabetes mellitus: a report from the European Society of Cardiology Cardiovascular Roundtable. Eur Heart J. 2019 09 07; 40(34):2907-2919. PMID: 30445605.
    Citations: 9     Fields:    Translation:Humans
  31. Mitchell S, Malanda B, Damasceno A, Eckel RH, Gaita D, Kotseva K, Januzzi JL, Mensah G, Plutzky J, Prystupiuk M, Ryden L, Thierer J, Virani SS, Sperling L. A Roadmap on the Prevention of Cardiovascular Disease Among People Living With Diabetes. Glob Heart. 2019 09; 14(3):215-240. PMID: 31451236.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  32. Fruchart JC, Santos RD, Aguilar-Salinas C, Aikawa M, Al Rasadi K, Amarenco P, Barter PJ, Ceska R, Corsini A, Després JP, Duriez P, Eckel RH, Ezhov MV, Farnier M, Ginsberg HN, Hermans MP, Ishibashi S, Karpe F, Kodama T, Koenig W, Krempf M, Lim S, Lorenzatti AJ, McPherson R, Nuñez-Cortes JM, Nordestgaard BG, Ogawa H, Packard CJ, Plutzky J, Ponte-Negretti CI, Pradhan A, Ray KK, Reiner Ž, Ridker PM, Ruscica M, Sadikot S, Shimano H, Sritara P, Stock JK, Su TC, Susekov AV, Tartar A, Taskinen MR, Tenenbaum A, Tokgözoglu LS, Tomlinson B, Tybjærg-Hansen A, Valensi P, Vrablík M, Wahli W, Watts GF, Yamashita S, Yokote K, Zambon A, Libby P. The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMa) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation. Cardiovasc Diabetol. 2019 06 04; 18(1):71. PMID: 31164165; PMCID: PMC6549355.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  33. Singh A, Gupta A, Collins BL, Qamar A, Monda KL, Biery D, Lopez JAG, de Ferranti SD, Plutzky J, Cannon CP, Januzzi JL, Di Carli MF, Nasir K, Bhatt DL, Blankstein R. Familial Hypercholesterolemia Among Young Adults With Myocardial Infarction. J Am Coll Cardiol. 2019 05 21; 73(19):2439-2450. PMID: 31097165.
    Citations: 16     Fields:    Translation:Humans
  34. Zhang M, Wang B, Urabe G, Huang Y, Plutzky J, Kent KC, Guo LW. The BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation. Cell Signal. 2019 09; 61:20-29. PMID: 31075399.
    Citations: 7     Fields:    Translation:AnimalsCells
  35. Muiru AN, Bibangambah P, Hemphill L, Sentongo R, Kim JH, Triant VA, Bangsberg DR, Tsai AC, Martin JN, Haberer JE, Boum Y, Plutzky J, Hunt PW, Okello S, Siedner MJ. Distribution and Performance of Cardiovascular Risk Scores in a Mixed Population of HIV-Infected and Community-Based HIV-Uninfected Individuals in Uganda. J Acquir Immune Defic Syndr. 2018 08 01; 78(4):458-464. PMID: 29652762; PMCID: PMC6019157.
    Citations: 9     Fields:    Translation:Humans
  36. Ganda OP, Plutzky J, Sanganalmath SK, Bujas-Bobanovic M, Koren A, Mandel J, Letierce A, Leiter LA. Efficacy and safety of alirocumab among individuals with diabetes mellitus and atherosclerotic cardiovascular disease in the ODYSSEY phase 3 trials. Diabetes Obes Metab. 2018 10; 20(10):2389-2398. PMID: 29802688.
    Citations: 8     Fields:    Translation:Humans
  37. Plutzky J, Liao KP. Lipids in RA: Is Less Not Necessarily More? Curr Rheumatol Rep. 2018 02 21; 20(2):8. PMID: 29464513.
    Citations: 6     Fields:    Translation:Humans
  38. Brown JD, Feldman ZB, Doherty SP, Reyes JM, Rahl PB, Lin CY, Sheng Q, Duan Q, Federation AJ, Kung AL, Haldar SM, Young RA, Plutzky J, Bradner JE. BET bromodomain proteins regulate enhancer function during adipogenesis. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2144-2149. PMID: 29444854.
    Citations: 28     Fields:    Translation:AnimalsCells
  39. Zhang H, Plutzky J, Ge W, Shubina M, Turchin A. Predictors of a successful statin reattempt after an adverse reaction. J Clin Lipidol. 2018 May - Jun; 12(3):643-651. PMID: 29567104.
    Citations: 1     Fields:    Translation:Humans
  40. Bertolami A, de Lima-Júnior JC, Cintra RM, Carvalho LS, Gonzaga CC, Sulzbach ML, Petisco ACGP, Barbosa JEM, Faludi AA, Plutzky J, Bertolami MC, Sposito AC. Adiponectin concentration data improve the estimation of atherosclerotic risk in normal and in overweight subjects. Clin Endocrinol (Oxf). 2018 03; 88(3):388-396. PMID: 29280189.
    Citations:    Fields:    Translation:Humans
  41. Plutzky J, Bakris G. Sodium/Glucose Cotransporter 2 Inhibitors in Patients With Diabetes Mellitus and Chronic Kidney Disease: Turning the Page. Circulation. 2018 01 09; 137(2):130-133. PMID: 29311346.
    Citations: 2     Fields:    Translation:Humans
  42. Singh A, Collins BL, Gupta A, Fatima A, Qamar A, Biery D, Baez J, Cawley M, Klein J, Hainer J, Plutzky J, Cannon CP, Nasir K, Di Carli MF, Bhatt DL, Blankstein R. Cardiovascular Risk and Statin Eligibility of Young Adults After an MI: Partners YOUNG-MI Registry. J Am Coll Cardiol. 2018 01 23; 71(3):292-302. PMID: 29141201; PMCID: PMC5831171.
    Citations: 45     Fields:    Translation:Humans
  43. Zhang H, Plutzky J, Shubina M, Turchin A. Continued Statin Prescriptions After Adverse Reactions and Patient Outcomes: A Cohort Study. Ann Intern Med. 2017 Aug 15; 167(4):221-227. PMID: 28738423.
    Citations: 23     Fields:    Translation:Humans
  44. Carroll SH, Zhang E, Wang BF, LeClair KB, Rahman A, Cohen DE, Plutzky J, Patwari P, Lee RT. Correction: Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in ß-adrenergic receptor signaling. PLoS One. 2017; 12(7):e0181492. PMID: 28700749.
    Citations: 2     Fields:    
  45. Carroll SH, Zhang E, Wang BF, LeClair KB, Rahman A, Cohen DE, Plutzky J, Patwari P, Lee RT. Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in ß-adrenergic receptor signaling. PLoS One. 2017; 12(3):e0173823. PMID: 28291835.
    Citations: 5     Fields:    Translation:AnimalsCells
  46. Zhang H, Plutzky J, Shubina M, Turchin A. Risk factors for lack of statin therapy in patients with diabetes and coronary artery disease. J Clin Lipidol. 2016 Nov - Dec; 10(6):1406-1413. PMID: 27919358.
    Citations: 4     Fields:    Translation:Humans
  47. Duan Q, Mao X, Liao C, Zhou H, Sun Z, Deng X, Hu Q, Qi J, Zhang G, Huang H, Plutzky J, Yang T. Inhibition of BET bromodomain attenuates angiotensin II induced abdominal aortic aneurysm in ApoE-/- mice. Int J Cardiol. 2016 Nov 15; 223:428-432. PMID: 27544600.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  48. Keating ST, Plutzky J, El-Osta A. Epigenetic Changes in Diabetes and Cardiovascular Risk. Circ Res. 2016 May 27; 118(11):1706-22. PMID: 27230637; PMCID: PMC5593074.
    Citations: 42     Fields:    Translation:HumansAnimals
  49. Zhang H, Plutzky J, Shubina M, Turchin A. Drivers of the Sex Disparity in Statin Therapy in Patients with Coronary Artery Disease: A Cohort Study. PLoS One. 2016; 11(5):e0155228. PMID: 27148965.
    Citations: 15     Fields:    Translation:Humans
  50. Liu Z, Xiao Y, Zhou Z, Mao X, Cai J, Xiong L, Liao C, Huang F, Liu Z, Ali Sheikh MS, Plutzky J, Huang H, Yang T, Duan Q. Extensive metabolic disorders are present in APC(min) tumorigenesis mice. Mol Cell Endocrinol. 2016 May 15; 427:57-64. PMID: 26948948.
    Citations: 4     Fields:    Translation:Animals
  51. Duan Q, Mao X, Xiao Y, Liu Z, Wang Y, Zhou H, Zhou Z, Cai J, Xia K, Zhu Q, Qi J, Huang H, Plutzky J, Yang T. Super enhancers at the miR-146a and miR-155 genes contribute to self-regulation of inflammation. Biochim Biophys Acta. 2016 Apr; 1859(4):564-71. PMID: 26855180.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  52. Kim SH, Plutzky J. Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders. Diabetes Metab J. 2016 Feb; 40(1):12-21. PMID: 26912151.
    Citations: 65     
  53. Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar SM, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MI. Differential role of an NF-?B transcriptional response element in endothelial versus intimal cell VCAM-1 expression. Circ Res. 2015 Jul 03; 117(2):166-77. PMID: 26034041.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  54. Rhee EJ, Park SE, Oh HG, Park CY, Oh KW, Park SW, Blankstein R, Plutzky J, Lee WY. Statin eligibility and cardiovascular risk burden assessed by coronary artery calcium score: comparing the two guidelines in a large Korean cohort. Atherosclerosis. 2015 May; 240(1):242-9. PMID: 25818250.
    Citations: 6     Fields:    Translation:Humans
  55. Lo J, Lu MT, Ihenachor EJ, Wei J, Looby SE, Fitch KV, Oh J, Zimmerman CO, Hwang J, Abbara S, Plutzky J, Robbins G, Tawakol A, Hoffmann U, Grinspoon SK. Effects of statin therapy on coronary artery plaque volume and high-risk plaque morphology in HIV-infected patients with subclinical atherosclerosis: a randomised, double-blind, placebo-controlled trial. Lancet HIV. 2015 Feb; 2(2):e52-63. PMID: 26424461; PMCID: PMC4820828.
    Citations: 96     Fields:    Translation:Humans
  56. Plutzky J. Emerging epigenetic maps in atherosclerosis. Circ Cardiovasc Genet. 2014 Oct; 7(5):573-5. PMID: 25518042.
    Citations:    Fields:    Translation:HumansCells
  57. Brown JD, Lin CY, Duan Q, Griffin G, Federation A, Paranal RM, Bair S, Newton G, Lichtman A, Kung A, Yang T, Wang H, Luscinskas FW, Croce K, Bradner JE, Plutzky J. NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis. Mol Cell. 2014 Oct 23; 56(2):219-231. PMID: 25263595.
    Citations: 276     Fields:    Translation:HumansAnimalsCells
  58. Pande RL, Brown J, Buck S, Redline W, Doyle J, Plutzky J, Creager MA. Association of monocyte tumor necrosis factor a expression and serum inflammatory biomarkers with walking impairment in peripheral artery disease. J Vasc Surg. 2015 Jan; 61(1):155-61. PMID: 25095746.
    Citations: 18     Fields:    Translation:HumansCells
  59. Halter JB, Musi N, McFarland Horne F, Crandall JP, Goldberg A, Harkless L, Hazzard WR, Huang ES, Kirkman MS, Plutzky J, Schmader KE, Zieman S, High KP. Diabetes and cardiovascular disease in older adults: current status and future directions. Diabetes. 2014 Aug; 63(8):2578-89. PMID: 25060886; PMCID: PMC4113072.
    Citations: 68     Fields:    Translation:Humans
  60. Nallamshetty S, Le PT, Wang H, Issacsohn MJ, Reeder DJ, Rhee EJ, Kiefer FW, Brown JD, Rosen CJ, Plutzky J. Retinaldehyde dehydrogenase 1 deficiency inhibits PPAR?-mediated bone loss and marrow adiposity. Bone. 2014 Oct; 67:281-91. PMID: 25064526.
    Citations: 3     Fields:    Translation:AnimalsCells
  61. Zhang H, Plutzky J, Turchin A. (Mis)interpreting studies on the adverse effects of statins. BMJ. 2014 Jun 11; 348:g3652. PMID: 24920686.
    Citations:    Fields:    Translation:Humans
  62. Fruchart JC, Davignon J, Hermans MP, Al-Rubeaan K, Amarenco P, Assmann G, Barter P, Betteridge J, Bruckert E, Cuevas A, Farnier M, Ferrannini E, Fioretto P, Genest J, Ginsberg HN, Gotto AM, Hu D, Kadowaki T, Kodama T, Krempf M, Matsuzawa Y, Núñez-Cortés JM, Monfil CC, Ogawa H, Plutzky J, Rader DJ, Sadikot S, Santos RD, Shlyakhto E, Sritara P, Sy R, Tall A, Tan CE, Tokgözoglu L, Toth PP, Valensi P, Wanner C, Zambon A, Zhu J, Zimmet P. Residual macrovascular risk in 2013: what have we learned? Cardiovasc Diabetol. 2014 Jan 24; 13:26. PMID: 24460800.
    Citations: 56     Fields:    Translation:HumansAnimals
  63. Fonseca VA, Devries JH, Henry RR, Donsmark M, Thomsen HF, Plutzky J. Reductions in systolic blood pressure with liraglutide in patients with type 2 diabetes: insights from a patient-level pooled analysis of six randomized clinical trials. J Diabetes Complications. 2014 May-Jun; 28(3):399-405. PMID: 24561125.
    Citations: 33     Fields:    Translation:Humans
  64. Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 2013 Oct 24; 502(7472):550-4. PMID: 24153306.
    Citations: 101     Fields:    Translation:AnimalsCells
  65. Chamarthi B, Zafrir B, Plutzky J, Givertz MM. Impact of pre-diabetes on heart transplant outcomes in patients with advanced heart failure. J Heart Lung Transplant. 2014 Feb; 33(2):215-7. PMID: 24315787.
    Citations: 3     Fields:    Translation:Humans
  66. Nallamshetty S, Wang H, Rhee EJ, Kiefer FW, Brown JD, Lotinun S, Le P, Baron R, Rosen CJ, Plutzky J. Deficiency of retinaldehyde dehydrogenase 1 induces BMP2 and increases bone mass in vivo. PLoS One. 2013; 8(8):e71307. PMID: 23951127.
    Citations: 12     Fields:    Translation:AnimalsCells
  67. Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SM. BET bromodomains mediate transcriptional pause release in heart failure. Cell. 2013 Aug 01; 154(3):569-82. PMID: 23911322.
    Citations: 157     Fields:    Translation:HumansAnimalsCells
  68. Zhang H, Plutzky J, Turchin A. Discontinuation of statins in routine care settings. Ann Intern Med. 2013 Jul 02; 159(1):75-6. PMID: 23817716.
    Citations: 7     Fields:    Translation:Humans
  69. Khera AV, Plutzky J. Management of low levels of high-density lipoprotein-cholesterol. Circulation. 2013 Jul 02; 128(1):72-8. PMID: 23817482; PMCID: PMC4231714.
    Citations: 4     Fields:    Translation:Humans
  70. Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1788-94. PMID: 23723371.
    Citations: 18     Fields:    Translation:AnimalsCells
  71. Zhang H, Plutzky J, Skentzos S, Morrison F, Mar P, Shubina M, Turchin A. Discontinuation of statins in routine care settings: a cohort study. Ann Intern Med. 2013 Apr 02; 158(7):526-34. PMID: 23546564; PMCID: PMC3692286.
    Citations: 161     Fields:    Translation:Humans
  72. Plutzky J, Garber A, Falahati A, Toft AD, Poulter NR. Reductions in lipids and CV risk markers in patients with type 2 diabetes treated with liraglutide: a meta-analysis. Can J Diabetes. 2009; 33(3):209-10. PMID: 25998594.
    Citations: 8     Fields:    
  73. Rosenson RS, Wright RS, Farkouh M, Plutzky J. Modulating peroxisome proliferator-activated receptors for therapeutic benefit? Biology, clinical experience, and future prospects. Am Heart J. 2012 Nov; 164(5):672-80. PMID: 23137497; PMCID: PMC4231713.
    Citations: 23     Fields:    Translation:HumansCells
  74. Kiefer FW, Cohen P, Plutzky J. Fifty shades of brown: perivascular fat, thermogenesis, and atherosclerosis. Circulation. 2012 Aug 28; 126(9):1012-5. PMID: 22927471; PMCID: PMC3711937.
    Citations: 10     Fields:    Translation:Animals
  75. de Ferranti SD, Daniels SR, Gillman M, Vernacchio L, Plutzky J, Baker AL. NHLBI Integrated Guidelines on Cardiovascular Disease Risk Reduction: can we clarify the controversy about cholesterol screening and treatment in childhood? Clin Chem. 2012 Dec; 58(12):1626-30. PMID: 22730451.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  76. Rhee EJ, Plutzky J. Retinoid metabolism and diabetes mellitus. Diabetes Metab J. 2012 Jun; 36(3):167-80. PMID: 22737656.
    Citations: 20     
  77. Kiefer FW, Vernochet C, O'Brien P, Spoerl S, Brown JD, Nallamshetty S, Zeyda M, Stulnig TM, Cohen DE, Kahn CR, Plutzky J. Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue. Nat Med. 2012 Jun; 18(6):918-25. PMID: 22561685.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  78. Lo J, Plutzky J. The biology of atherosclerosis: general paradigms and distinct pathogenic mechanisms among HIV-infected patients. J Infect Dis. 2012 Jun; 205 Suppl 3:S368-74. PMID: 22577210; PMCID: PMC3349296.
    Citations: 24     Fields:    Translation:Humans
  79. Elmasri H, Ghelfi E, Yu CW, Traphagen S, Cernadas M, Cao H, Shi GP, Plutzky J, Sahin M, Hotamisligil G, Cataltepe S. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway. Angiogenesis. 2012 Sep; 15(3):457-68. PMID: 22562362.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  80. Kiefer FW, Orasanu G, Nallamshetty S, Brown JD, Wang H, Luger P, Qi NR, Burant CF, Duester G, Plutzky J. Retinaldehyde dehydrogenase 1 coordinates hepatic gluconeogenesis and lipid metabolism. Endocrinology. 2012 Jul; 153(7):3089-99. PMID: 22555438; PMCID: PMC3380298.
    Citations: 38     Fields:    Translation:AnimalsCells
  81. Jain M, Plutzky J. Commentary. Clin Chem. 2012 May; 58(5):829-30. PMID: 22544857.
    Citations:    Fields:    Translation:Humans
  82. Plutzky J. The incretin axis in cardiovascular disease. Circulation. 2011 Nov 22; 124(21):2285-9. PMID: 22105195.
    Citations: 5     Fields:    Translation:AnimalsCells
  83. Shetty S, Ramos-Roman MA, Cho YR, Brown J, Plutzky J, Muise ES, Horton JD, Scherer PE, Parks EJ. Enhanced fatty acid flux triggered by adiponectin overexpression. Endocrinology. 2012 Jan; 153(1):113-22. PMID: 22045665; PMCID: PMC3249680.
    Citations: 21     Fields:    Translation:AnimalsCells
  84. Skentzos S, Shubina M, Plutzky J, Turchin A. Structured vs. unstructured: factors affecting adverse drug reaction documentation in an EMR repository. AMIA Annu Symp Proc. 2011; 2011:1270-9. PMID: 22195188.
    Citations: 20     Fields:    Translation:Humans
  85. Shabrova EV, Tarnopolsky O, Singh AP, Plutzky J, Vorsa N, Quadro L. Insights into the molecular mechanisms of the anti-atherogenic actions of flavonoids in normal and obese mice. PLoS One. 2011; 6(10):e24634. PMID: 22016761.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  86. Blaser BW, Kim HT, Alyea EP, Ho VT, Cutler C, Armand P, Koreth J, Antin JH, Plutzky J, Soiffer RJ. Hyperlipidemia and statin use after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2012 Apr; 18(4):575-83. PMID: 21839706.
    Citations: 17     Fields:    Translation:Humans
  87. Davidson MH, Plutzky J. The role of cardiologists in the management of patients with diabetes is evolving owing to the close relationship between diabetes and CAD. Introduction. Am J Cardiol. 2011 Aug 02; 108(3 Suppl):1B-2B. PMID: 21802576.
    Citations:    Fields:    Translation:Humans
  88. Plutzky J. Macrovascular effects and safety issues of therapies for type 2 diabetes. Am J Cardiol. 2011 Aug 02; 108(3 Suppl):25B-32B. PMID: 21802578.
    Citations: 13     Fields:    Translation:Humans
  89. Rhee EJ, Nallamshetty S, Plutzky J. Retinoid metabolism and its effects on the vasculature. Biochim Biophys Acta. 2012 Jan; 1821(1):230-40. PMID: 21810483.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  90. Brown JD, Oligino E, Rader DJ, Saghatelian A, Plutzky J. VLDL hydrolysis by hepatic lipase regulates PPARd transcriptional responses. PLoS One. 2011; 6(7):e21209. PMID: 21750705.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  91. Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. Nat Med. 2011 Jun 12; 17(7):812-5. PMID: 21666694.
    Citations: 91     Fields:    Translation:HumansAnimals
  92. Kiefer FW, Neschen S, Pfau B, Legerer B, Neuhofer A, Kahle M, Hrabé de Angelis M, Schlederer M, Mair M, Kenner L, Plutzky J, Zeyda M, Stulnig TM. Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice. Diabetologia. 2011 Aug; 54(8):2132-42. PMID: 21562757.
    Citations: 40     Fields:    Translation:Animals
  93. Plutzky J. The PPAR-RXR transcriptional complex in the vasculature: energy in the balance. Circ Res. 2011 Apr 15; 108(8):1002-16. PMID: 21493923.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  94. Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FA. Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):1933-9. PMID: 20689078.
    Citations: 29     Fields:    Translation:AnimalsCells
  95. Fonseca VA, Zinman B, Nauck MA, Goldfine AB, Plutzky J. Confronting the type 2 diabetes epidemic: the emerging role of incretin-based therapies. Am J Med. 2010 Jul; 123(7):S2-S10. PMID: 20609666.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  96. Ruby MA, Goldenson B, Orasanu G, Johnston TP, Plutzky J, Krauss RM. VLDL hydrolysis by LPL activates PPAR-alpha through generation of unbound fatty acids. J Lipid Res. 2010 Aug; 51(8):2275-81. PMID: 20421589.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  97. Chutkow WA, Birkenfeld AL, Brown JD, Lee HY, Frederick DW, Yoshioka J, Patwari P, Kursawe R, Cushman SW, Plutzky J, Shulman GI, Samuel VT, Lee RT. Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes. 2010 Jun; 59(6):1424-34. PMID: 20299477; PMCID: PMC2874703.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  98. Brown J, Nallamshetty S, Plutzky J. Intersecting vectors of basic science research and clinical medicine: LOX-1? Clin Chem. 2010 Apr; 56(4):499-501. PMID: 20185618.
    Citations: 1     Fields:    Translation:HumansAnimals
  99. Plutzky J. Expansion and contraction: the mighty, mighty fatty acid. Nat Med. 2009 Jun; 15(6):618-9. PMID: 19498375.
    Citations: 6     Fields:    Translation:HumansAnimals
  100. Orasanu G, Plutzky J. The pathologic continuum of diabetic vascular disease. J Am Coll Cardiol. 2009 Feb 03; 53(5 Suppl):S35-42. PMID: 19179216; PMCID: PMC2663393.
    Citations: 131     Fields:    Translation:HumansCells
  101. Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky J. PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice. J Clin Invest. 2009 Jan; 119(1):110-24. PMID: 19065047; PMCID: PMC2613459.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  102. Fruchart JC, Sacks F, Hermans MP, Assmann G, Brown WV, Ceska R, Chapman MJ, Dodson PM, Fioretto P, Ginsberg HN, Kadowaki T, Lablanche JM, Marx N, Plutzky J, Reiner Z, Rosenson RS, Staels B, Stock JK, Sy R, Wanner C, Zambon A, Zimmet P. The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia. Am J Cardiol. 2008 Nov 17; 102(10 Suppl):1K-34K. PMID: 19068318.
    Citations: 100     Fields:    Translation:Humans
  103. Fruchart JC, Sacks FM, Hermans MP, Assmann G, Brown WV, Ceska R, Chapman MJ, Dodson PM, Fioretto P, Ginsberg HN, Kadowaki T, Lablanche JM, Marx N, Plutzky J, Reiner Z, Rosenson RS, Staels B, Stock JK, Sy R, Wanner C, Zambon A, Zimmet P. The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient. Diab Vasc Dis Res. 2008 Nov; 5(4):319-35. PMID: 18958843.
    Citations: 62     Fields:    Translation:Humans
  104. Orasanu G, Ziouzenkova O, Devchand PR, Nehra V, Hamdy O, Horton ES, Plutzky J. The peroxisome proliferator-activated receptor-gamma agonist pioglitazone represses inflammation in a peroxisome proliferator-activated receptor-alpha-dependent manner in vitro and in vivo in mice. J Am Coll Cardiol. 2008 Sep 02; 52(10):869-81. PMID: 18755353; PMCID: PMC2633943.
    Citations: 42     Fields:    Translation:HumansAnimalsCTClinical Trials
  105. Mazzone T, Chait A, Plutzky J. Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies. Lancet. 2008 May 24; 371(9626):1800-9. PMID: 18502305; PMCID: PMC2774464.
    Citations: 184     Fields:    Translation:Humans
  106. Paruchuri S, Jiang Y, Feng C, Francis SA, Plutzky J, Boyce JA. Leukotriene E4 activates peroxisome proliferator-activated receptor gamma and induces prostaglandin D2 generation by human mast cells. J Biol Chem. 2008 Jun 13; 283(24):16477-87. PMID: 18411276.
    Citations: 46     Fields:    Translation:HumansCells
  107. Kanda T, Wakino S, Hayashi K, Plutzky J. Cardiovascular disease, chronic kidney disease, and type 2 diabetes mellitus: proceeding with caution at a dangerous intersection. J Am Soc Nephrol. 2008 Jan; 19(1):4-7. PMID: 18178795.
    Citations: 5     Fields:    Translation:Humans
  108. Plutzky J. A cardiologist's perspective on cardiometabolic risk. Am J Cardiol. 2007 Dec 17; 100(12A):3P-6P. PMID: 18154744.
    Citations: 1     Fields:    Translation:Humans
  109. Ziouzenkova O, Plutzky J. Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex. FEBS Lett. 2008 Jan 09; 582(1):32-8. PMID: 18068127.
    Citations: 75     Fields:    Translation:AnimalsCells
  110. Plutzky J. Preventing type 2 diabetes and cardiovascular disease in metabolic syndrome: the role of PPARalpha. Diab Vasc Dis Res. 2007 Sep; 4 Suppl 3:S12-4. PMID: 17935055.
    Citations: 3     Fields:    Translation:Humans
  111. Ahmed W, Ziouzenkova O, Brown J, Devchand P, Francis S, Kadakia M, Kanda T, Orasanu G, Sharlach M, Zandbergen F, Plutzky J. PPARs and their metabolic modulation: new mechanisms for transcriptional regulation? J Intern Med. 2007 Aug; 262(2):184-98. PMID: 17645586.
    Citations: 52     Fields:    Translation:HumansCells
  112. Ziouzenkova O, Orasanu G, Sharlach M, Akiyama TE, Berger JP, Viereck J, Hamilton JA, Tang G, Dolnikowski GG, Vogel S, Duester G, Plutzky J. Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med. 2007 Jun; 13(6):695-702. PMID: 17529981; PMCID: PMC2233696.
    Citations: 179     Fields:    Translation:HumansAnimalsCells
  113. Zandbergen F, Plutzky J. PPARalpha in atherosclerosis and inflammation. Biochim Biophys Acta. 2007 Aug; 1771(8):972-82. PMID: 17631413; PMCID: PMC2083576.
    Citations: 74     Fields:    Translation:HumansCells
  114. Brown JD, Plutzky J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation. 2007 Jan 30; 115(4):518-33. PMID: 17261671.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  115. Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, Fonseca V, Gerstein HC, Grundy S, Nesto RW, Pignone MP, Plutzky J, Porte D, Redberg R, Stitzel KF, Stone NJ. Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Diabetes Care. 2007 Jan; 30(1):162-72. PMID: 17192355.
    Citations: 155     Fields:    Translation:HumansPHPublic Health
  116. Buse JB, Ginsberg HN, Bakris GL, Clark NG, Costa F, Eckel R, Fonseca V, Gerstein HC, Grundy S, Nesto RW, Pignone MP, Plutzky J, Porte D, Redberg R, Stitzel KF, Stone NJ. Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation. 2007 Jan 02; 115(1):114-26. PMID: 17192512.
    Citations: 222     Fields:    Translation:Humans
  117. Libby P, Plutzky J. Inflammation in diabetes mellitus: role of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma agonists. Am J Cardiol. 2007 Feb 19; 99(4A):27B-40B. PMID: 17307056.
    Citations: 39     Fields:    Translation:Humans
  118. Dzau VJ, Antman EM, Black HR, Hayes DL, Manson JE, Plutzky J, Popma JJ, Stevenson W. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part II: Clinical trial evidence (acute coronary syndromes through renal disease) and future directions. Circulation. 2006 Dec 19; 114(25):2871-91. PMID: 17179035.
    Citations: 26     Fields:    Translation:Humans
  119. Dzau VJ, Antman EM, Black HR, Hayes DL, Manson JE, Plutzky J, Popma JJ, Stevenson W. The cardiovascular disease continuum validated: clinical evidence of improved patient outcomes: part I: Pathophysiology and clinical trial evidence (risk factors through stable coronary artery disease). Circulation. 2006 Dec 19; 114(25):2850-70. PMID: 17179034.
    Citations: 101     Fields:    Translation:Humans
  120. Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, Wahli W. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev. 2006 Dec; 58(4):726-41. PMID: 17132851.
    Citations: 344     Fields:    Translation:HumansAnimalsCells
  121. Ziouzenkova O, Orasanu G, Sukhova G, Lau E, Berger JP, Tang G, Krinsky NI, Dolnikowski GG, Plutzky J. Asymmetric cleavage of beta-carotene yields a transcriptional repressor of retinoid X receptor and peroxisome proliferator-activated receptor responses. Mol Endocrinol. 2007 Jan; 21(1):77-88. PMID: 17008383.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  122. Han CY, Chiba T, Campbell JS, Fausto N, Chaisson M, Orasanu G, Plutzky J, Chait A. Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes. Arterioscler Thromb Vasc Biol. 2006 Aug; 26(8):1806-13. PMID: 16709944.
    Citations: 56     Fields:    Translation:AnimalsCells
  123. Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, Plutzky J. High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion. Circ Res. 2006 Mar 03; 98(4):490-8. PMID: 16439686; PMCID: PMC4231787.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  124. Lee CH, Plutzky J. Liver X receptor activation and high-density lipoprotein biology: a reversal of fortune? Circulation. 2006 Jan 03; 113(1):5-8. PMID: 16391165.
    Citations: 1     Fields:    Translation:Humans
  125. Oligino E, Ziouzenkova O, Plutzky J. . VLDL hydrolysis by hepatic lipase is a distinct mechanism for PPAR-delta activation. Sarnoff Endowment, Washington, DC. 2006.
  126. Gornik HL, Plutzky J. . Dyslipidemia. In: Gaziano JM, editor. Atlas of Cardiovascular Risk Factors. 2005; 97-114.
  127. McMahon GT, Plutzky J, Daher E, Bhattacharyya T, Grunberger G, DiCarli MF. Effect of a peroxisome proliferator-activated receptor-gamma agonist on myocardial blood flow in type 2 diabetes. Diabetes Care. 2005 May; 28(5):1145-50. PMID: 15855580.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  128. Plutzky J, Ziouzenkova O. . Lipoprotein lipase and lipoprotein lipase activators in the treatment of inflammatory conditions. 2005.
  129. Orasanu G, Ziouzenkova O, Plutzky J. . Peroxisome proliferator activated receptors (PPARs) – potential targets for diabetic atherosclerosis. In: Cheta D, editor. Vascular Involvement in Diabetes. 2005; 35-49.
  130. Drexler AJ, Nesto RW, Abrahamson MJ, Bakris G, Bell D, Brunzell J, Dandona P, Davidson J, Fonseca V, Fowler M, Frye R, Giles T, Haffner S, Hollenberg N, Hsueh W, Law R, Plutzky J, Ratner R, Reusch J, Selwyn A, Sowers J, Wyne K, Young LH. Evaluating the cardiovascular effects of the thiazolidinediones and their place in the management of type 2 diabetes in relation to the metabolic syndrome. Metab Syndr Relat Disord. 2005; 3(2):147-73. PMID: 18370723.
    Citations:    Fields:    
  131. Plutzky J. . Peroxisome proliferator-activated receptors in diabetes, vascular inflammation, and atherosclerosis (DVD, audio tape). 2005.
  132. Devchand PR, Ziouzenkova O, Plutzky J. Oxidative stress and peroxisome proliferator-activated receptors: reversing the curse? Circ Res. 2004 Dec 10; 95(12):1137-9. PMID: 15591235.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  133. Plutzky J. Inflammation in atherosclerosis and diabetes mellitus. Rev Endocr Metab Disord. 2004 Aug; 5(3):255-9. PMID: 15211097.
    Citations: 7     Fields:    Translation:Humans
  134. Ziouzenkova O, Plutzky J. Lipolytic PPAR activation: new insights into the intersection of triglycerides and inflammation? Curr Opin Clin Nutr Metab Care. 2004 Jul; 7(4):369-75. PMID: 15192437.
    Citations: 9     Fields:    Translation:HumansCells
  135. Plutzky J. PPARs: altering clinical responses in Type 2 diabetes and atherosclerosis. Introduction. Clin Cardiol. 2004 Jul; 27(7 Suppl 4):IV1-2. PMID: 15470904.
    Citations:    Fields:    Translation:Humans
  136. Ziouzenkova O, Plutzky J. . Exogenous and endogenous mechanisms of PPAR activation: implications for inflammation and atherosclerosis. International Congress Series. 2004; 1262:147-151.
  137. Ahmed W, Ziouzenkova O, Orasanu G, Marchadier D, Rader D, Plutzky J. . Endothelial lipase acts on HDL to activate PPAR?. American Heart Association Scientific Sessions, New Orleans, LA. 2004.
  138. Orasanu G, Ziouzenkova O, Ahmed W, Shoelson S, Plutzky J. Lipoprotein metabolism and uptake direct divergent peroxisome proliferator-activated receptor-? and hepatocyte nuclear factor 4? responses. American Heart Association Scientific Sessions, New Orleans, LA. 2004.
  139. Plutzky J. The vascular biology of atherosclerosis. Am J Med. 2003 Dec 08; 115 Suppl 8A:55S-61S. PMID: 14678867.
    Citations: 8     Fields:    Translation:Humans
  140. Plutzky J. Peroxisome proliferator-activated receptors as therapeutic targets in inflammation. J Am Coll Cardiol. 2003 Nov 19; 42(10):1764-6. PMID: 14642685.
    Citations: 9     Fields:    Translation:Humans
  141. Beckman J, Raji A, Plutzky J. Peroxisome proliferator activated receptor gamma and its activation in the treatment of insulin resistance and atherosclerosis: issues and opportunities. Curr Opin Cardiol. 2003 Nov; 18(6):479-85. PMID: 14597889.
    Citations: 2     Fields:    Translation:Humans
  142. Plutzky J. Medicine. PPARs as therapeutic targets: reverse cardiology? Science. 2003 Oct 17; 302(5644):406-7. PMID: 14563997.
    Citations: 20     Fields:    Translation:AnimalsCells
  143. Plutzky J. The potential role of peroxisome proliferator-activated receptors on inflammation in type 2 diabetes mellitus and atherosclerosis. Am J Cardiol. 2003 Aug 18; 92(4A):34J-41J. PMID: 12957325.
    Citations: 7     Fields:    Translation:HumansCells
  144. Ziouzenkova O, Asatryan L, Sahady D, Orasanu G, Perrey S, Cutak B, Hassell T, Akiyama TE, Berger JP, Sevanian A, Plutzky J. Dual roles for lipolysis and oxidation in peroxisome proliferation-activator receptor responses to electronegative low density lipoprotein. J Biol Chem. 2003 Oct 10; 278(41):39874-81. PMID: 12878589.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  145. Plutzky J. . PPARs and atherosclerosis. In: Duttaroy AK, Spener F, editors. Cellular proteins and their fatty acids in health and disease. 2003; Chapter 23.
  146. Plutzky J. Diabetes as a vascular disease. Dyslipidemia as a target. Postgrad Med. 2003 Apr; 113(4 Suppl):15-23. PMID: 19667619.
    Citations:    Fields:    Translation:Humans
  147. Ridker PM, Cook NR, Cheng S, Erlich HA, Lindpaintner K, Plutzky J, Zee RY. Alanine for proline substitution in the peroxisome proliferator-activated receptor gamma-2 (PPARG2) gene and the risk of incident myocardial infarction. Arterioscler Thromb Vasc Biol. 2003 May 01; 23(5):859-63. PMID: 12663371; PMCID: PMC4231712.
    Citations: 33     Fields:    Translation:Humans
  148. Ziouzenkova O, Perrey S, Asatryan L, Hwang J, MacNaul KL, Moller DE, Rader DJ, Sevanian A, Zechner R, Hoefler G, Plutzky J. Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2730-5. PMID: 12606719; PMCID: PMC151409.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  149. Kramer D, Raji A, Plutzky J. Prediabetes mellitus and its links to atherosclerosis. Curr Diab Rep. 2003 Feb; 3(1):11-8. PMID: 12643141.
    Citations: 3     Fields:    Translation:Humans
  150. Plutzky J, Libby P. . Pathophysiology of atherosclerotic heart disease. In: Tonkin AM, editor. Atherosclerosis and Heart Disease. 2003; 1-12.
  151. Plutzky J. . PPARs. In: Izzo JL, Black HR, editors. Hypertension Primer. 2003; 60-62.
  152. Libby P, Plutzky J. Diabetic macrovascular disease: the glucose paradox? Circulation. 2002 Nov 26; 106(22):2760-3. PMID: 12450998.
    Citations: 35     Fields:    Translation:Humans
  153. Raji A, Plutzky J. Insulin resistance, diabetes, and atherosclerosis: thiazolidinediones as therapeutic interventions. Curr Cardiol Rep. 2002 Nov; 4(6):514-21. PMID: 12379175.
    Citations: 5     Fields:    Translation:HumansAnimals
  154. Plutzky J, Viberti G, Haffner S. Atherosclerosis in type 2 diabetes mellitus and insulin resistance: mechanistic links and therapeutic targets. J Diabetes Complications. 2002 Nov-Dec; 16(6):401-15. PMID: 12477625.
    Citations: 20     Fields:    Translation:HumansAnimals
  155. Sethi S, Ziouzenkova O, Ni H, Wagner DD, Plutzky J, Mayadas TN. Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha. Blood. 2002 Aug 15; 100(4):1340-6. PMID: 12149216.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  156. Marx N, Kehrle B, Kohlhammer K, Grüb M, Koenig W, Hombach V, Libby P, Plutzky J. PPAR activators as antiinflammatory mediators in human T lymphocytes: implications for atherosclerosis and transplantation-associated arteriosclerosis. Circ Res. 2002 Apr 05; 90(6):703-10. PMID: 11934839; PMCID: PMC4231718.
    Citations: 91     Fields:    Translation:HumansCells
  157. Plutzky J. . The role of high-density lipoprotein (HDL) cholesterol in the prevention and treatment of coronary heart disease. Am J Cardiol. 2002; 90(7 ): 139-143.
  158. Ziouzenkova O, Perrey S, Marx N, Bacqueville D, Plutzky J. Peroxisome proliferator-activated receptors. Curr Atheroscler Rep. 2002 Jan; 4(1):59-64. PMID: 11772424.
    Citations: 6     Fields:    Translation:Humans
  159. Plutzky J, Libby P. . Diabetes and cardiovascular disease (DVD). 2002.
  160. Plutzky J. Inflammatory pathways in atherosclerosis and acute coronary syndromes. Am J Cardiol. 2001 Oct 18; 88(8A):10K-15K. PMID: 11694213.
    Citations: 56     Fields:    Translation:Humans
  161. Plutzky J. Peroxisome proliferator-activated receptors in endothelial cell biology. Curr Opin Lipidol. 2001 Oct; 12(5):511-8. PMID: 11561170.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  162. Marx N, Libby P, Plutzky J. Peroxisome proliferator-activated receptors (PPARs) and their role in the vessel wall: possible mediators of cardiovascular risk? J Cardiovasc Risk. 2001 Aug; 8(4):203-10. PMID: 11550998.
    Citations: 9     Fields:    Translation:Humans
  163. Plutzky J, Davidson J. . Diabetes and cardiovascular disease in the Hispanic population, (CD-ROM). 2001.
  164. Plutzky J, Ridker PM. Statins for stroke: the second story? Circulation. 2001 Jan 23; 103(3):348-50. PMID: 11157683.
    Citations: 1     Fields:    Translation:Humans
  165. Marx N, Mackman N, Schönbeck U, Yilmaz N, Hombach V, Libby P, Plutzky J. PPARalpha activators inhibit tissue factor expression and activity in human monocytes. Circulation. 2001 Jan 16; 103(2):213-9. PMID: 11208679.
    Citations: 43     Fields:    Translation:HumansCells
  166. Plutzky J. . PPARs and diabetic atherosclerosis. 2001.
  167. Plutzky J. . Insulin resistance and atherosclerosis. 2001.
  168. Plutzky J. Emerging concepts in metabolic abnormalities associated with coronary artery disease. Curr Opin Cardiol. 2000 Nov; 15(6):416-21. PMID: 11198624.
    Citations: 7     Fields:    Translation:HumansAnimals
  169. Plutzky J. Peroxisome proliferator-activated receptors in vascular biology and atherosclerosis: emerging insights for evolving paradigms. Curr Atheroscler Rep. 2000 Jul; 2(4):327-35. PMID: 11122762.
    Citations: 23     Fields:    Translation:HumansCells
  170. Marx N, Mach F, Sauty A, Leung JH, Sarafi MN, Ransohoff RM, Libby P, Plutzky J, Luster AD. Peroxisome proliferator-activated receptor-gamma activators inhibit IFN-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J Immunol. 2000 Jun 15; 164(12):6503-8. PMID: 10843708; PMCID: PMC4231715.
    Citations: 74     Fields:    Translation:HumansCells
  171. Plutzky J. . PPARs and diabetic atherosclerosis. 2000.
  172. Plutzky J. . Atherosclerosis: an insulin resistance disorder. Proceedings from the Second Annual US/Japanese Dialogue on Lipids and Atherosclerosis. 2000; 245:49-58.
  173. Libby P, Aikawa M, Schönbeck U, Sukhova G, Mach F, Marx N, Plutzky J. . Inflammation and plaque stability. 2000.
  174. Libby P, Aikawa M, Schoenbeck U, Sukhova G, Mach F, Marx N, Plutzky J. . Inflammation and plaque stability. In: Stemme S, Olsson AG, editors. Atherosclerosis XII. 2000; 67-80.
  175. Plutzky J, Libby P, Nakamura H. Second annual US/Japanese dialogue on lipids and atherosclerosis: towards an understanding of mechanism. 2000.
  176. Ginsberg H, Plutzky J, Sobel BE. A review of metabolic and cardiovascular effects of oral antidiabetic agents: beyond glucose-level lowering. J Cardiovasc Risk. 1999 Oct; 6(5):337-46. PMID: 10534139.
    Citations: 8     Fields:    Translation:Humans
  177. Kinlay S, Plutzky J. Effect of lipid-lowering therapy on vasomotion and endothelial function. Curr Cardiol Rep. 1999 Sep; 1(3):238-43. PMID: 10980848.
    Citations: 5     Fields:    Translation:Humans
  178. Plutzky J. Atherosclerotic plaque rupture: emerging insights and opportunities. Am J Cardiol. 1999 Jul 08; 84(1A):15J-20J. PMID: 10418853.
    Citations: 17     Fields:    Translation:Humans
  179. Marx N, Sukhova GK, Collins T, Libby P, Plutzky J. PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation. 1999 Jun 22; 99(24):3125-31. PMID: 10377075; PMCID: PMC4231776.
    Citations: 129     Fields:    Translation:HumansCells
  180. Marx N, Bourcier T, Sukhova GK, Libby P, Plutzky J. PPARgamma activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression: PPARgamma as a potential mediator in vascular disease. Arterioscler Thromb Vasc Biol. 1999 Mar; 19(3):546-51. PMID: 10073956.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  181. Plutzky J. . Making sense of clinical trials in lipid lowering. Intensive review of internal medicine (CD-ROM). 1999.
  182. Plutzky J. . Coronary artery disease in the younger patient. New issues for the next millennium. 1999; 238:75-83.
  183. Marx N, Schönbeck U, Lazar MA, Libby P, Plutzky J. Peroxisome proliferator-activated receptor gamma activators inhibit gene expression and migration in human vascular smooth muscle cells. Circ Res. 1998 Nov 30; 83(11):1097-103. PMID: 9831704; PMCID: PMC4231720.
    Citations: 124     Fields:    Translation:HumansCells
  184. Marx N, Sukhova G, Murphy C, Libby P, Plutzky J. Macrophages in human atheroma contain PPARgamma: differentiation-dependent peroxisomal proliferator-activated receptor gamma(PPARgamma) expression and reduction of MMP-9 activity through PPARgamma activation in mononuclear phagocytes in vitro. Am J Pathol. 1998 Jul; 153(1):17-23. PMID: 9665460; PMCID: PMC1852950.
    Citations: 119     Fields:    Translation:HumansCells
  185. Laufs U, La Fata V, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation. 1998 Mar 31; 97(12):1129-35. PMID: 9537338.
    Citations: 369     Fields:    Translation:HumansAnimalsCells
  186. Plutzky J. . Myocardial infarction in the younger patient. Cannon CP, editor. Management of acute coronary syndrome. 1998; 653-666. .
  187. Plutzky J. . Disorders of the heart and vascular system. Harrison’s Principles of Internal Medicine Self-Assessment and Review. 1998; 49-90. .
  188. Blumnethal RS, Plutzky J. Secondary prevention of myocardial infarction. Cannon CP, editor. Management of acute coronary syndrome. 1998; 695-704.
  189. Oberg K, Cannon C, Plutzky J. Focus on reteplase: a newly approved third-generation thrombolytic agent for the treatment of acute myocardial infarction. Formulary. 1997; 32:37-45.
  190. Freeman R, Plutzky J, Neel B, Rosenberg R. Methods for identifying a tyrosine phosphatase abnormally associated with neoplastic disease. 1996.
  191. Neel BG, Plutzky J, Rosenberg RD, Freeman RM, Lorenz U, Lechleider RJ. . Molecular cloning and characterization of a subfamily of nontransmembrane PTPs containing src homology 2 (SH2) domains. Adv Protein Phosphatases. 1993; 7:127-151.
  192. Freeman RM, Plutzky J, Neel BG. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11239-43. PMID: 1280823; PMCID: PMC50525.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  193. Plutzky J, Neel BG, Rosenberg RD, Eddy RL, Byers MG, Jani-Sait S, Shows TB. Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6). Genomics. 1992 Jul; 13(3):869-72. PMID: 1639416.
    Citations: 9     Fields:    Translation:HumansCells
  194. Plutzky J, Neel BG, Rosenberg RD. Isolation of a src homology 2-containing tyrosine phosphatase. Proc Natl Acad Sci U S A. 1992 Feb 01; 89(3):1123-7. PMID: 1736296; PMCID: PMC48398.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  195. Plutzky J. On being a physician. Am J Med. 1990 Aug; 89(2):252. PMID: 2382677.
    Citations:    Fields:    Translation:Humans
  196. Plutzky J, Hoskins JA, Long GL, Crabtree GR. Evolution and organization of the human protein C gene. Proc Natl Acad Sci U S A. 1986 Feb; 83(3):546-50. PMID: 3511471; PMCID: PMC322900.
    Citations: 25     Fields:    Translation:HumansCells
  197. Beckmann RJ, Schmidt RJ, Santerre RF, Plutzky J, Crabtree GR, Long GL. The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs. Nucleic Acids Res. 1985 Jul 25; 13(14):5233-47. PMID: 2991859; PMCID: PMC321861.
    Citations: 24     Fields:    Translation:HumansCells