Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Andrea I. McClatchey, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK127177 (MCCLATCHEY, ANDREA I) Jan 1, 2021 - Dec 31, 2024
    Inside-out construction of the biliary system
    Role: Principal Investigator
  2. R13CA216892 (MCCLATCHEY, ANDREA I) May 1, 2017 - Apr 30, 2018
    2017 Cell Contact and Adhesion Gordon Research Conference and Gordon Research Seminar
    Role: Principal Investigator
  3. R01GM087558 (FEHON, RICHARD G) Jan 1, 2010 - Dec 31, 2014
    Functional analysis of ERM proteins in epithelial morphogenesis
    Role: Co-Principal Investigator
  4. R01CA113733 (MCCLATCHEY, ANDREA I) Aug 1, 2005 - May 31, 2016
    Molecular Function of the Nf2 Tumor Suppressor, Merlin
    Role: Principal Investigator
  5. P30CA006516 (GLIMCHER, LAURIE HOLLIS) Nov 30, 2021
    Dana-Farber/Harvard Cancer Center
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. McClatchey AI. EPHecting cell contact by increasing cortical tension. J Cell Biol. 2021 06 07; 220(6). PMID: 33999116.
    Citations:    Fields:    Translation:Cells
  2. Kutys ML, Polacheck WJ, Welch MK, Gagnon KA, Koorman T, Kim S, Li L, McClatchey AI, Chen CS. Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform. Nat Commun. 2020 07 06; 11(1):3377. PMID: 32632100.
    Citations: 7     Fields:    Translation:HumansCells
  3. McClatchey AI, Georgopoulos K. Actin' Up to Stop SNFin Out TEAD. Dev Cell. 2018 12 17; 47(6):693-695. PMID: 30562513.
    Citations:    Fields:    Translation:Cells
  4. Chiasson-MacKenzie C, Morris ZS, Liu CH, Bradford WB, Koorman T, McClatchey AI. Merlin/ERM proteins regulate growth factor-induced macropinocytosis and receptor recycling by organizing the plasma membrane:cytoskeleton interface. Genes Dev. 2018 09 01; 32(17-18):1201-1214. PMID: 30143526; PMCID: PMC6120716.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  5. Chiasson-MacKenzie C, McClatchey AI. Cell-Cell Contact and Receptor Tyrosine Kinase Signaling. Cold Spring Harb Perspect Biol. 2018 06 01; 10(6). PMID: 28716887.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  6. Benhamouche-Trouillet S, O'Loughlin E, Liu CH, Polacheck W, Fitamant J, McKee M, El-Bardeesy N, Chen CS, McClatchey AI. Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis. Development. 2018 04 30; 145(9). PMID: 29712669.
    Citations: 5     Fields:    Translation:Animals
  7. Chiasson-MacKenzie C, McClatchey AI. EGFR-induced cytoskeletal changes drive complex cell behaviors: The tip of the iceberg. Sci Signal. 2018 01 30; 11(515). PMID: 29382786.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Chiasson-MacKenzie C, Morris ZS, Baca Q, Morris B, Coker JK, Mirchev R, Jensen AE, Carey T, Stott SL, Golan DE, McClatchey AI. NF2/Merlin mediates contact-dependent inhibition of EGFR mobility and internalization via cortical actomyosin. J Cell Biol. 2015 Oct 26; 211(2):391-405. PMID: 26483553; PMCID: PMC4621825.
    Citations: 23     Fields:    Translation:AnimalsCells
  9. Fitamant J, Kottakis F, Benhamouche S, Tian HS, Chuvin N, Parachoniak CA, Nagle JM, Perera RM, Lapouge M, Deshpande V, Zhu AX, Lai A, Min B, Hoshida Y, Avruch J, Sia D, Campreciós G, McClatchey AI, Llovet JM, Morrissey D, Raj L, Bardeesy N. YAP Inhibition Restores Hepatocyte Differentiation in Advanced HCC, Leading to Tumor Regression. Cell Rep. 2015 Mar 17; 10(10):1692-1707. PMID: 25772357.
    Citations: 105     Fields:    
  10. Plotkin SR, Albers AC, Babovic-Vuksanovic D, Blakeley JO, Breakefield XO, Dunn CM, Evans DG, Fisher MJ, Friedman JM, Giovannini M, Gutmann DH, Kalamarides M, McClatchey AI, Messiaen L, Morrison H, Parkinson DB, Stemmer-Rachamimov AO, Van Raamsdonk CD, Riccardi VM, Rosser T, Schindeler A, Smith MJ, Stevenson DA, Ullrich NJ, van der Vaart T, Weiss B, Widemann BC, Zhu Y, Bakker AC, Lloyd AC. Update from the 2013 International Neurofibromatosis Conference. Am J Med Genet A. 2014 Dec; 164A(12):2969-78. PMID: 25255738; PMCID: PMC4236251.
    Citations: 6     Fields:    Translation:HumansAnimals
  11. McClatchey AI. ERM proteins at a glance. J Cell Sci. 2014 Aug 01; 127(Pt 15):3199-204. PMID: 24951115.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  12. Shapiro IM, Kolev VN, Vidal CM, Kadariya Y, Ring JE, Wright Q, Weaver DT, Menges C, Padval M, McClatchey AI, Xu Q, Testa JR, Pachter JA. Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship. Sci Transl Med. 2014 May 21; 6(237):237ra68. PMID: 24848258.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  13. Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, Gutmann DH, Hanemann CO, Hennigan R, Huson S, Ingram D, Kissil J, Korf BR, Legius E, Packer RJ, McClatchey AI, McCormick F, North K, Pehrsson M, Plotkin SR, Ramesh V, Ratner N, Schirmer S, Sherman L, Schorry E, Stevenson D, Stewart DR, Ullrich N, Bakker AC, Morrison H. CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. Am J Med Genet A. 2014 Mar; 164A(3):563-78. PMID: 24443315.
    Citations: 8     Fields:    Translation:Humans
  14. Pore D, Parameswaran N, Matsui K, Stone MB, Saotome I, McClatchey AI, Veatch SL, Gupta N. Ezrin tunes the magnitude of humoral immunity. J Immunol. 2013 Oct 15; 191(8):4048-58. PMID: 24043890; PMCID: PMC3808844.
    Citations: 15     Fields:    Translation:AnimalsCells
  15. Hebert AM, DuBoff B, Casaletto JB, Gladden AB, McClatchey AI. Merlin/ERM proteins establish cortical asymmetry and centrosome position. Genes Dev. 2012 Dec 15; 26(24):2709-23. PMID: 23249734.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  16. McClatchey AI. ERM proteins. Curr Biol. 2012 Sep 25; 22(18):R784-5. PMID: 23017986.
    Citations: 7     Fields:    Translation:AnimalsCells
  17. McClatchey AI, Yap AS. Contact inhibition (of proliferation) redux. Curr Opin Cell Biol. 2012 Oct; 24(5):685-94. PMID: 22835462.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  18. McClatchey AI, Cichowski K. SPRED proteins provide a NF-ty link to Ras suppression. Genes Dev. 2012 Jul 15; 26(14):1515-9. PMID: 22802525.
    Citations: 8     Fields:    Translation:HumansAnimals
  19. Casaletto JB, McClatchey AI. Spatial regulation of receptor tyrosine kinases in development and cancer. Nat Rev Cancer. 2012 May 24; 12(6):387-400. PMID: 22622641.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  20. Blakeley JO, Evans DG, Adler J, Brackmann D, Chen R, Ferner RE, Hanemann CO, Harris G, Huson SM, Jacob A, Kalamarides M, Karajannis MA, Korf BR, Mautner VF, McClatchey AI, Miao H, Plotkin SR, Slattery W, Stemmer-Rachamimov AO, Welling DB, Wen PY, Widemann B, Hunter-Schaedle K, Giovannini M. Consensus recommendations for current treatments and accelerating clinical trials for patients with neurofibromatosis type 2. Am J Med Genet A. 2012 Jan; 158A(1):24-41. PMID: 22140088.
    Citations: 37     Fields:    Translation:Humans
  21. Casaletto JB, Saotome I, Curto M, McClatchey AI. Ezrin-mediated apical integrity is required for intestinal homeostasis. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11924-9. PMID: 21730140.
    Citations: 42     Fields:    Translation:Animals
  22. Heiska L, Melikova M, Zhao F, Saotome I, McClatchey AI, Carpén O. Ezrin is key regulator of Src-induced malignant phenotype in three-dimensional environment. Oncogene. 2011 Dec 15; 30(50):4953-62. PMID: 21666723.
    Citations: 19     Fields:    Translation:AnimalsCells
  23. Gladden AB, Hebert AM, Schneeberger EE, McClatchey AI. The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell. 2010 Nov 16; 19(5):727-39. PMID: 21074722.
    Citations: 92     Fields:    Translation:AnimalsCells
  24. Shaffer MH, Huang Y, Corbo E, Wu GF, Velez M, Choi JK, Saotome I, Cannon JL, McClatchey AI, Sperling AI, Maltzman JS, Oliver PM, Bhandoola A, Laufer TM, Burkhardt JK. Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice. PLoS One. 2010 Aug 27; 5(8):e12404. PMID: 20806059.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Benhamouche S, Curto M, Saotome I, Gladden AB, Liu CH, Giovannini M, McClatchey AI. Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev. 2010 Aug 15; 24(16):1718-30. PMID: 20675406; PMCID: PMC2922501.
    Citations: 137     Fields:    Translation:AnimalsCells
  26. Wong HK, Lahdenranta J, Kamoun WS, Chan AW, McClatchey AI, Plotkin SR, Jain RK, di Tomaso E. Anti-vascular endothelial growth factor therapies as a novel therapeutic approach to treating neurofibromatosis-related tumors. Cancer Res. 2010 May 01; 70(9):3483-93. PMID: 20406973; PMCID: PMC4785015.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  27. Fehon RG, McClatchey AI, Bretscher A. Organizing the cell cortex: the role of ERM proteins. Nat Rev Mol Cell Biol. 2010 Apr; 11(4):276-87. PMID: 20308985.
    Citations: 479     Fields:    Translation:HumansAnimalsCells
  28. Evans DG, Kalamarides M, Hunter-Schaedle K, Blakeley J, Allen J, Babovic-Vuskanovic D, Belzberg A, Bollag G, Chen R, DiTomaso E, Golfinos J, Harris G, Jacob A, Kalpana G, Karajannis M, Korf B, Kurzrock R, Law M, McClatchey A, Packer R, Roehm P, Rubenstein A, Slattery W, Tonsgard JH, Welling DB, Widemann B, Yohay K, Giovannini M. Consensus recommendations to accelerate clinical trials for neurofibromatosis type 2. Clin Cancer Res. 2009 Aug 15; 15(16):5032-5039. PMID: 19671848.
    Citations: 29     Fields:    Translation:HumansAnimals
  29. Morris ZS, McClatchey AI. Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9767-72. PMID: 19487675.
    Citations: 27     Fields:    Translation:AnimalsCells
  30. Morris ZS, McClatchey AI. The neurofibroma cell of origin: SKPs expand the playing field. Cell Stem Cell. 2009 May 08; 4(5):371-2. PMID: 19427284.
    Citations: 2     Fields:    Translation:AnimalsCells
  31. McClatchey AI, Fehon RG. Merlin and the ERM proteins--regulators of receptor distribution and signaling at the cell cortex. Trends Cell Biol. 2009 May; 19(5):198-206. PMID: 19345106.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  32. Shaffer MH, Dupree RS, Zhu P, Saotome I, Schmidt RF, McClatchey AI, Freedman BD, Burkhardt JK. Ezrin and moesin function together to promote T cell activation. J Immunol. 2009 Jan 15; 182(2):1021-32. PMID: 19124745; PMCID: PMC3491660.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  33. Larsson J, Ohishi M, Garrison B, Aspling M, Janzen V, Adams GB, Curto M, McClatchey AI, Schipani E, Scadden DT. Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture. Cell Stem Cell. 2008 Aug 07; 3(2):221-7. PMID: 18682243.
    Citations: 16     Fields:    Translation:AnimalsCells
  34. Plotkin SR, Singh MA, O'Donnell CC, Harris GJ, McClatchey AI, Halpin C. Audiologic and radiographic response of NF2-related vestibular schwannoma to erlotinib therapy. Nat Clin Pract Oncol. 2008 Aug; 5(8):487-91. PMID: 18560388.
    Citations: 21     Fields:    Translation:Humans
  35. Kim WJ, Okimoto RA, Purton LE, Goodwin M, Haserlat SM, Dayyani F, Sweetser DA, McClatchey AI, Bernard OA, Look AT, Bell DW, Scadden DT, Haber DA. Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias. Blood. 2008 May 01; 111(9):4716-22. PMID: 18299447; PMCID: PMC2343601.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  36. Johannessen CM, Johnson BW, Williams SM, Chan AW, Reczek EE, Lynch RC, Rioth MJ, McClatchey A, Ryeom S, Cichowski K. TORC1 is essential for NF1-associated malignancies. Curr Biol. 2008 Jan 08; 18(1):56-62. PMID: 18164202.
    Citations: 102     Fields:    Translation:AnimalsCells
  37. Cole BK, Curto M, Chan AW, McClatchey AI. Localization to the cortical cytoskeleton is necessary for Nf2/merlin-dependent epidermal growth factor receptor silencing. Mol Cell Biol. 2008 Feb; 28(4):1274-84. PMID: 18086884.
    Citations: 49     Fields:    Translation:AnimalsCells
  38. Curto M, McClatchey AI. Nf2/Merlin: a coordinator of receptor signalling and intercellular contact. Br J Cancer. 2008 Jan 29; 98(2):256-62. PMID: 17971776.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  39. Curto M, Cole BK, Lallemand D, Liu CH, McClatchey AI. Contact-dependent inhibition of EGFR signaling by Nf2/Merlin. J Cell Biol. 2007 Jun 04; 177(5):893-903. PMID: 17548515; PMCID: PMC2064288.
    Citations: 171     Fields:    Translation:AnimalsCells
  40. Bruce B, Khanna G, Ren L, Landberg G, Jirström K, Powell C, Borczuk A, Keller ET, Wojno KJ, Meltzer P, Baird K, McClatchey A, Bretscher A, Hewitt SM, Khanna C. Expression of the cytoskeleton linker protein ezrin in human cancers. Clin Exp Metastasis. 2007; 24(2):69-78. PMID: 17370041.
    Citations: 58     Fields:    Translation:HumansCells
  41. McClatchey AI. Neurofibromatosis. Annu Rev Pathol. 2007; 2:191-216. PMID: 18039098.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  42. Bonilha VL, Rayborn ME, Saotome I, McClatchey AI, Hollyfield JG. Microvilli defects in retinas of ezrin knockout mice. Exp Eye Res. 2006 Apr; 82(4):720-9. PMID: 16289046.
    Citations: 36     Fields:    Translation:AnimalsCells
  43. McClatchey AI, Giovannini M. Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin. Genes Dev. 2005 Oct 01; 19(19):2265-77. PMID: 16204178.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  44. Altomare DA, Vaslet CA, Skele KL, De Rienzo A, Devarajan K, Jhanwar SC, McClatchey AI, Kane AB, Testa JR. A mouse model recapitulating molecular features of human mesothelioma. Cancer Res. 2005 Sep 15; 65(18):8090-5. PMID: 16166281.
    Citations: 67     Fields:    Translation:HumansAnimals
  45. Saotome I, Curto M, McClatchey AI. Ezrin is essential for epithelial organization and villus morphogenesis in the developing intestine. Dev Cell. 2004 Jun; 6(6):855-64. PMID: 15177033.
    Citations: 197     Fields:    Translation:AnimalsCells
  46. Stemmer-Rachamimov AO, Louis DN, Nielsen GP, Antonescu CR, Borowsky AD, Bronson RT, Burns DK, Cervera P, McLaughlin ME, Reifenberger G, Schmale MC, MacCollin M, Chao RC, Cichowski K, Kalamarides M, Messerli SM, McClatchey AI, Niwa-Kawakita M, Ratner N, Reilly KM, Zhu Y, Giovannini M. Comparative pathology of nerve sheath tumors in mouse models and humans. Cancer Res. 2004 May 15; 64(10):3718-24. PMID: 15150133.
    Citations: 41     Fields:    Translation:HumansAnimals
  47. Curto M, McClatchey AI. Ezrin...a metastatic detERMinant? Cancer Cell. 2004 Feb; 5(2):113-4. PMID: 14998486.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  48. McClatchey AI. Merlin and ERM proteins: unappreciated roles in cancer development? Nat Rev Cancer. 2003 11; 3(11):877-83. PMID: 14668818.
    Citations: 70     Fields:    Translation:HumansCells
  49. Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey AI. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev. 2003 May 01; 17(9):1090-100. PMID: 12695331; PMCID: PMC196046.
    Citations: 124     Fields:    Translation:AnimalsCells
  50. Yajnik V, Paulding C, Sordella R, McClatchey AI, Saito M, Wahrer DC, Reynolds P, Bell DW, Lake R, van den Heuvel S, Settleman J, Haber DA. DOCK4, a GTPase activator, is disrupted during tumorigenesis. Cell. 2003 Mar 07; 112(5):673-84. PMID: 12628187.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  51. Weiss WA, Israel M, Cobbs C, Holland E, James CD, Louis DN, Marks C, McClatchey AI, Roberts T, Van Dyke T, Wetmore C, Chiu IM, Giovannini M, Guha A, Higgins RJ, Marino S, Radovanovic I, Reilly K, Aldape K. Neuropathology of genetically engineered mice: consensus report and recommendations from an international forum. Oncogene. 2002 Oct 24; 21(49):7453-63. PMID: 12386807.
    Citations: 22     Fields:    Translation:Animals
  52. Shaw RJ, Paez JG, Curto M, Yaktine A, Pruitt WM, Saotome I, O'Bryan JP, Gupta V, Ratner N, Der CJ, Jacks T, McClatchey AI. The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling. Dev Cell. 2001 Jul; 1(1):63-72. PMID: 11703924.
    Citations: 142     Fields:    Translation:AnimalsCells
  53. McClatchey AI, Cichowski K. Mouse models of neurofibromatosis. Biochim Biophys Acta. 2001; 1471(2):M73-80. PMID: 11342186.
    Citations: 2     Fields:    Translation:HumansAnimals
  54. Lim DJ, Rubenstein AE, Evans DG, Jacks T, Seizinger BG, Baser ME, Beebe D, Brackmann DE, Chiocca EA, Fehon RG, Giovannini M, Glazer R, Gusella JF, Gutmann DH, Korf B, Lieberman F, Martuza R, McClatchey AI, Parry DM, Pulst SM, Ramesh V, Ramsey WJ, Ratner N, Rutkowski JL, Ruttledge M, Weinstein DE. Advances in neurofibromatosis 2 (NF2): a workshop report. J Neurogenet. 2000 Jun; 14(2):63-106. PMID: 10992163.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  55. McClatchey AI. Neurofibromatosis type II: mouse models reveal broad roles in tumorigenesis and metastasis. Mol Med Today. 2000 Jun; 6(6):252-3. PMID: 10840384.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  56. McClatchey AI. Modeling metastasis in the mouse. Oncogene. 1999 Sep 20; 18(38):5334-9. PMID: 10498886.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  57. McClatchey AI, Jacks T. Tumor suppressor mutations in mice: the next generation. Curr Opin Genet Dev. 1998 Jun; 8(3):304-10. PMID: 9690995.
    Citations: 4     Fields:    Translation:HumansAnimals
  58. McClatchey AI, Saotome I, Mercer K, Crowley D, Gusella JF, Bronson RT, Jacks T. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev. 1998 Apr 15; 12(8):1121-33. PMID: 9553042; PMCID: PMC316711.
    Citations: 120     Fields:    Translation:HumansAnimalsCells
  59. Shaw RJ, McClatchey AI, Jacks T. Localization and functional domains of the neurofibromatosis type II tumor suppressor, merlin. Cell Growth Differ. 1998 Apr; 9(4):287-96. PMID: 9563848.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  60. Shaw RJ, McClatchey AI, Jacks T. Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. J Biol Chem. 1998 Mar 27; 273(13):7757-64. PMID: 9516485.
    Citations: 40     Fields:    Translation:AnimalsCells
  61. McClatchey AI, Saotome I, Ramesh V, Gusella JF, Jacks T. The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. Genes Dev. 1997 May 15; 11(10):1253-65. PMID: 9171370.
    Citations: 59     Fields:    Translation:Animals
  62. Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, Jacks T. p53 status and the efficacy of cancer therapy in vivo. Science. 1994 Nov 04; 266(5186):807-10. PMID: 7973635.
    Citations: 313     Fields:    Translation:Animals
  63. Lowe SW, Bodis S, Bardeesy N, McClatchey A, Remington L, Ruley HE, Fisher DE, Jacks T, Pelletier J, Housman DE. Apoptosis and the prognostic significance of p53 mutation. Cold Spring Harb Symp Quant Biol. 1994; 59:419-26. PMID: 7587096.
    Citations: 5     Fields:    Translation:HumansAnimals
  64. McClatchey AI, Cannon SC, Slaugenhaupt SA, Gusella JF. The cloning and expression of a sodium channel beta 1-subunit cDNA from human brain. Hum Mol Genet. 1993 Jun; 2(6):745-9. PMID: 8394762.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  65. Cannon SC, McClatchey AI, Gusella JF. Modification of the Na+ current conducted by the rat skeletal muscle alpha subunit by coexpression with a human brain beta subunit. Pflugers Arch. 1993 Apr; 423(1-2):155-7. PMID: 7683789.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  66. Allitto BA, McClatchey AI, Barnes G, Altherr M, Wasmuth J, Frischauf AM, MacDonald ME, Gusella J. Assay by polymerase chain reaction (PCR) of multi-allele polymorphisms in the Huntington's disease region of chromosome 4. Mol Cell Probes. 1992 Dec; 6(6):513-20. PMID: 1480191.
    Citations: 3     Fields:    Translation:HumansCells
  67. McClatchey AI, Lin CS, Wang J, Hoffman EP, Rojas C, Gusella JF. The genomic structure of the human skeletal muscle sodium channel gene. Hum Mol Genet. 1992 Oct; 1(7):521-7. PMID: 1339144.
    Citations: 11     Fields:    Translation:HumansCells
  68. McClatchey AI, McKenna-Yasek D, Cros D, Worthen HG, Kuncl RW, DeSilva SM, Cornblath DR, Gusella JF, Brown RH. Novel mutations in families with unusual and variable disorders of the skeletal muscle sodium channel. Nat Genet. 1992 Oct; 2(2):148-52. PMID: 1338909.
    Citations: 34     Fields:    Translation:HumansCells
  69. Youngman S, Bates GP, Williams S, McClatchey AI, Baxendale S, Sedlacek Z, Altherr M, Wasmuth JJ, MacDonald ME, Gusella JF, et al. The telomeric 60 kb of chromosome arm 4p is homologous to telomeric regions on 13p, 15p, 21p, and 22p. Genomics. 1992 Oct; 14(2):350-6. PMID: 1427851.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  70. McClatchey AI, Trofatter J, McKenna-Yasek D, Raskind W, Bird T, Pericak-Vance M, Gilchrist J, Arahata K, Radosavljevic D, Worthen HG, et al. Dinucleotide repeat polymorphisms at the SCN4A locus suggest allelic heterogeneity of hyperkalemic periodic paralysis and paramyotonia congenita. Am J Hum Genet. 1992 May; 50(5):896-901. PMID: 1315122; PMCID: PMC1682609.
    Citations: 9     Fields:    Translation:HumansCells
  71. Gusella JF, Altherr MR, McClatchey AI, Doucette-Stamm LA, Tagle D, Plummer S, Groot N, Barnes G, Hummerich H, Collins FS, et al. Sequence-tagged sites (STSs) spanning 4p16.3 and the Huntington disease candidate region. Genomics. 1992 May; 13(1):75-80. PMID: 1533609.
    Citations:    Fields:    Translation:HumansCells
  72. McClatchey AI, Van den Bergh P, Pericak-Vance MA, Raskind W, Verellen C, McKenna-Yasek D, Rao K, Haines JL, Bird T, Brown RH, et al. Temperature-sensitive mutations in the III-IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita. Cell. 1992 Feb 21; 68(4):769-74. PMID: 1310898.
    Citations: 40     Fields:    Translation:HumansCells
  73. Horn GT, McClatchey AI, Richards B, MacDonald ME, Gusella JF. Detection by PCR of a VNTR polymorphism at D4S43. Nucleic Acids Res. 1991 Sep 11; 19(17):4772. PMID: 1679922; PMCID: PMC328726.
    Citations: 3     Fields:    Translation:HumansCells
  74. Allitto BA, Horn GT, Altherr MR, Richards B, McClatchey AI, Wasmuth JJ, Gusella JF. Detection by PCR of the VNTR polymorphism at D4S95. Nucleic Acids Res. 1991 Jul 25; 19(14):4015. PMID: 1677758; PMCID: PMC328517.
    Citations: 1     Fields:    Translation:HumansCells
  75. Kaufman DL, Ramesh V, McClatchey AI, Menkes JH, Tobin AJ. Detection of point mutations associated with genetic diseases by an exon scanning technique. Genomics. 1990 Dec; 8(4):656-63. PMID: 2276738.
    Citations: 4     Fields:    Translation:HumansCells
  76. McClatchey AI, Kaufman DL, Berson EL, Tobin AJ, Shih VE, Gusella JF, Ramesh V. Splicing defect at the ornithine aminotransferase (OAT) locus in gyrate atrophy. Am J Hum Genet. 1990 Nov; 47(5):790-4. PMID: 2220818; PMCID: PMC1683684.
    Citations: 6     Fields:    Translation:HumansCells
  77. Ramesh V, McClatchey AI, Ramesh N, Benoit LA, Berson EL, Shih VE, Gusella JF. Molecular basis of ornithine aminotransferase deficiency in B-6-responsive and -nonresponsive forms of gyrate atrophy. Proc Natl Acad Sci U S A. 1988 Jun; 85(11):3777-80. PMID: 3375240; PMCID: PMC280301.
    Citations: 13     Fields:    Translation:Humans
  78. Tanzi RE, McClatchey AI, Lamperti ED, Villa-Komaroff L, Gusella JF, Neve RL. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Nature. 1988 Feb 11; 331(6156):528-30. PMID: 2893290.
    Citations: 213     Fields:    Translation:HumansCells
  79. Tanzi RE, St George-Hyslop PH, Haines JL, Polinsky RJ, Nee L, Foncin JF, Neve RL, McClatchey AI, Conneally PM, Gusella JF. The genetic defect in familial Alzheimer's disease is not tightly linked to the amyloid beta-protein gene. Nature. 1987 Sep 10-16; 329(6135):156-7. PMID: 2888020.
    Citations: 39     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.