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Matthias Nahrendorf, M.D.

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Biography
education and training
University of Heidelberg , GermanyMD04/1998Medicine
Harvard Medical School, Boston, USAM. Sc. 04/217(Hon)
awards and honors
2020
Martin Research Prize
2020
Rolf Sammet Guest Professor, Frankfurt University
2020
Endowed Chair, MGH Research Institute
2019
Adjunct Professor of Medicine, Julius-Maximilians-Universität Würzburg
2018
Appointed to NHLBI board of external experts
2017
Chair Atherosclerosis Gordon Research Conference
2015
Basic Research Award, German Society of Cardiology
2014
MGH Research Scholar Award
2013
Member, American Society of Clinical Investigation

Overview
overview
The Nahrendorf laboratory focuses on the role of immunity in cardiovascular health and disease, specifically in atherosclerosis and heart failure. Of particular interest are the function, supply and production of leukocytes, and the signals that regulate hematopoiesis after injuries such as myocardial infarction or stroke. We described that after MI, the spleen releases a large population of ready-made leukocytes that travel to the ischemic heart (Science 2009, New York Times 2009). We further found that MI, chronic stress and sedentary life style modulate the hematopoietic stem cell niche, activating migration and proliferation of myeloid progenitor cells (Nature 2012, Nature Med 2014, Nature Med 2019). Resident macrophages, on the other hand, do not derive from circulating cells and promote steady state functions such as cardiac conduction (Cell 2017). The laboratory also develops and employs imaging to sample biology non-invasively, using MR, nuclear, optical and microscopic modalities.
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. P01HL142494 (NAHRENDORF, MATTHIAS) Aug 1, 2019 - Jul 31, 2024
    NIH
    Hematopoiesis in cardiovascular disease
    Role: Principal Investigator
  2. R01NS108419 (MOSKOWITZ, MICHAEL A. ;NAHRENDORF, MATTHIAS) Sep 30, 2018 - Jul 31, 2024
    NIH
    Skull marrow crosstalk with the central nervous system
    Role: Co-Principal Investigator
  3. R35HL139598 (NAHRENDORF, MATTHIAS) Feb 1, 2018 - Jan 31, 2025
    NIH
    Imaging organ system interfaces in ischemic heart disease
    Role: Principal Investigator
  4. R13HL137211 (NAHRENDORF, MATTHIAS) May 1, 2017 - Apr 30, 2018
    NIH
    2017 Atherosclerosis Gordon Research Conference & Gordon Research Seminar
    Role: Principal Investigator
  5. R01HL131495 (NAHRENDORF, MATTHIAS) Feb 1, 2017 - Jan 31, 2021
    NIH
    Quantitative nanoparticle imaging of macrophages
    Role: Principal Investigator

Bibliographic
selected publications
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.