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Matthias Nahrendorf, M.D.

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Biography
University of Heidelberg , GermanyMD04/1998Medicine
Harvard Medical School, Boston, USAM. Sc. 04/217(Hon)
2020
Martin Research Prize
2020
Rolf Sammet Guest Professor, Frankfurt University
2020
Endowed Chair, MGH Research Institute
2019
Adjunct Professor of Medicine, Julius-Maximilians-Universität Würzburg
2018
Appointed to NHLBI board of external experts
2017
Chair Atherosclerosis Gordon Research Conference
2015
Basic Research Award, German Society of Cardiology
2014
MGH Research Scholar Award
2013
Member, American Society of Clinical Investigation

Overview
The Nahrendorf laboratory focuses on the role of immunity in cardiovascular health and disease, specifically in atherosclerosis and heart failure. Of particular interest are the function, supply and production of leukocytes, and the signals that regulate hematopoiesis after injuries such as myocardial infarction or stroke. We described that after MI, the spleen releases a large population of ready-made leukocytes that travel to the ischemic heart (Science 2009, New York Times 2009). We further found that MI, chronic stress and sedentary life style modulate the hematopoietic stem cell niche, activating migration and proliferation of myeloid progenitor cells (Nature 2012, Nature Med 2014, Nature Med 2019). Resident macrophages, on the other hand, do not derive from circulating cells and promote steady state functions such as cardiac conduction (Cell 2017). The laboratory also develops and employs imaging to sample biology non-invasively, using MR, nuclear, optical and microscopic modalities.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01HL142494 (NAHRENDORF, MATTHIAS) Aug 1, 2019 - Jul 31, 2024
    NIH/NHLBI
    Hematopoiesis in cardiovascular disease
    Role: Principal Investigator
  2. R01NS108419 (MOSKOWITZ, MICHAEL A.) Sep 30, 2018 - Jul 31, 2023
    NIH/NINDS
    Skull marrow crosstalk with the central nervous system
    Role: Co-Principal Investigator
  3. R35HL139598 (NAHRENDORF, MATTHIAS) Feb 1, 2018 - Jan 31, 2025
    NIH/NHLBI
    Imaging organ system interfaces in ischemic heart disease
    Role: Principal Investigator
  4. R13HL137211 (NAHRENDORF, MATTHIAS) May 1, 2017 - Apr 30, 2018
    NIH/NHLBI
    2017 Atherosclerosis Gordon Research Conference & Gordon Research Seminar
    Role: Principal Investigator
  5. R01HL131495 (NAHRENDORF, MATTHIAS) Feb 1, 2017 - Jan 31, 2021
    NIH/NHLBI
    Quantitative nanoparticle imaging of macrophages
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Xiao L, Salem JE, Clauss S, Hanley A, Bapat A, Hulsmans M, Iwamoto Y, Wojtkiewicz G, Cetinbas M, Schloss MJ, Tedeschi J, Lebrun-Vignes B, Lundby A, Sadreyev RI, Moslehi JJ, Nahrendorf M, Ellinor PT, Milan DJ. Ibrutinib-Mediated Atrial Fibrillation Due to Inhibition of CSK. Circulation. 2020 Oct 23. PMID: 33092403.
    Citations:    
  2. Nahrendorf M, Hoyer FF, Meerwaldt AE, van Leent MMT, Senders ML, Calcagno C, Robson PM, Soultanidis G, Pérez-Medina C, Teunissen AJP, Toner YC, Ishikawa K, Fish K, Sakurai K, van Leeuwen EM, Klein ED, Sofias AM, Reiner T, Rohde D, Aguirre AD, Wojtkiewicz G, Schmidt S, Iwamoto Y, Izquierdo-Garcia D, Caravan P, Swirski FK, Weissleder R, Mulder WJM. Imaging Cardiovascular and Lung Macrophages With the Positron Emission Tomography Sensor 64Cu-Macrin in Mice, Rabbits, and Pigs. Circ Cardiovasc Imaging. 2020 Oct; 13(10):e010586. PMID: 33076700.
    Citations:    
  3. Chan CT, Fenn AM, Harder NK, Mindur JE, McAlpine CS, Patel J, Valet C, Rattik S, Iwamoto Y, He S, Anzai A, Kahles F, Poller WC, Janssen H, Wong LP, Fernandez-Hernando C, Koolbergen DR, van der Laan AM, Yvan-Charvet L, Sadreyev RI, Nahrendorf M, Westerterp M, Tall AR, Gustafsson JA, Swirski FK. Liver X receptors are required for thymic resilience and T cell output. J Exp Med. 2020 Oct 05; 217(10). PMID: 32716519.
    Citations:    
  4. Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Nayar R, Frodermann V, Hulsmans M, Chung A, Hoyer FF, Swirski FK, Langer R, Anderson DG, Nahrendorf M. Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nat Biomed Eng. 2020 Oct 05. PMID: 33020600.
    Citations:    
  5. Nahrendorf M, Abbate A, Narula J. Correction to: Deciphering post-infarct inflammation: Should it heal, would it hurt? J Nucl Cardiol. 2020 Aug; 27(4):1384. PMID: 32140993.
    Citations:    
  6. Liu CL, Liu X, Wang Y, Deng Z, Liu T, Sukhova GK, Wojtkiewicz GR, Tang R, Zhang JY, Achilefu S, Nahrendorf M, Libby P, Wang X, Shi GP. Reduced Nhe1 (Na+-H+ Exchanger-1) Function Protects ApoE-Deficient Mice From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysms. Hypertension. 2020 Jul; 76(1):87-100. PMID: 32475310.
    Citations:    
  7. Schloss MJ, Swirski FK, Nahrendorf M. Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity. Circ Res. 2020 04 24; 126(9):1242-1259. PMID: 32324501.
    Citations:    
  8. Hoyer FF, Zhang X, Coppin E, Vasamsetti SB, Modugu G, Schloss MJ, Rohde D, McAlpine CS, Iwamoto Y, Libby P, Naxerova K, Swirski FK, Dutta P, Nahrendorf M. Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes Mellitus. Circulation. 2020 Jul 21; 142(3):244-258. PMID: 32316750.
    Citations:    
  9. Hadjikhani N, Albrecht DS, Mainero C, Ichijo E, Ward N, Granziera C, Zürcher NR, Akeju O, Bonnier G, Price J, Hooker JM, Napadow V, Nahrendorf M, Loggia ML, Moskowitz MA. Extra-Axial Inflammatory Signal in Parameninges in Migraine with Visual Aura. Ann Neurol. 2020 06; 87(6):939-949. PMID: 32239542.
    Citations:    
  10. Senders ML, Meerwaldt AE, van Leent MMT, Sanchez-Gaytan BL, van de Voort JC, Toner YC, Maier A, Klein ED, Sullivan NAT, Sofias AM, Groenen H, Faries C, Oosterwijk RS, van Leeuwen EM, Fay F, Chepurko E, Reiner T, Duivenvoorden R, Zangi L, Dijkhuizen RM, Hak S, Swirski FK, Nahrendorf M, Pérez-Medina C, Teunissen AJP, Fayad ZA, Calcagno C, Strijkers GJ, Mulder WJM. Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging. Nat Nanotechnol. 2020 May; 15(5):398-405. PMID: 32313216.
    Citations:    
  11. Poller WC, Nahrendorf M, Swirski FK. Hematopoiesis and Cardiovascular Disease. Circ Res. 2020 04 10; 126(8):1061-1085. PMID: 32271679.
    Citations:    
  12. Vinegoni C, Fumene Feruglio P, Courties G, Schmidt S, Hulsmans M, Lee S, Wang R, Sosnovik D, Nahrendorf M, Weissleder R. Fluorescence microscopy tensor imaging representations for large-scale dataset analysis. Sci Rep. 2020 03 27; 10(1):5632. PMID: 32221334.
    Citations:    
  13. Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS. A durable murine model of spleen transplantation with arterial and venous anastomoses. Sci Rep. 2020 03 04; 10(1):3979. PMID: 32132617.
    Citations:    
  14. Cremer S, Schloss MJ, Vinegoni C, Foy BH, Zhang S, Rohde D, Hulsmans M, Fumene Feruglio P, Schmidt S, Wojtkiewicz G, Higgins JM, Weissleder R, Swirski FK, Nahrendorf M. Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction. J Am Coll Cardiol. 2020 Mar 03; 75(8):901-915. PMID: 32130926.
    Citations:    
  15. Hulsmans M, Nahrendorf M. Proliferative, degradative smooth muscle cells promote aortic disease. J Clin Invest. 2020 03 02; 130(3):1096-1098. PMID: 32039919.
    Citations:    
  16. Leuschner F, Nahrendorf M. Novel functions of macrophages in the heart: insights into electrical conduction, stress, and diastolic dysfunction. Eur Heart J. 2020 Mar 01; 41(9):989-994. PMID: 30945736.
    Citations:    
  17. Nahrendorf M, Abbate A, Narula J. Deciphering post-infarct inflammation: Should it heal, would it hurt? J Nucl Cardiol. 2020 Feb 21. PMID: 32086743.
    Citations:    
  18. Libby P, Swirski FK, Nahrendorf M. The Myocardium: More Than Myocytes. J Am Coll Cardiol. 2019 12 24; 74(25):3136-3138. PMID: 31856970.
    Citations:    
  19. Vagnozzi RJ, Maillet M, Sargent MA, Khalil H, Johansen AKZ, Schwanekamp JA, York AJ, Huang V, Nahrendorf M, Sadayappan S, Molkentin JD. An acute immune response underlies the benefit of cardiac stem cell therapy. Nature. 2020 01; 577(7790):405-409. PMID: 31775156.
    Citations:    
  20. Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M. Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity. 2019 11 19; 51(5):899-914.e7. PMID: 31732166.
    Citations:    
  21. Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager SCA, Sadreyev RI, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M. Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells. Nat Med. 2019 11; 25(11):1761-1771. PMID: 31700184.
    Citations:    
  22. Hoyer FF, Nahrendorf M. Interferon-? regulates cardiac myeloid cells in myocardial infarction. Cardiovasc Res. 2019 11 01; 115(13):1815-1816. PMID: 31161218.
    Citations:    
  23. Kalman JM, Lavandero S, Mahfoud F, Nahrendorf M, Yacoub MH, Zhao D. Looking back and thinking forwards - 15 years of cardiology and cardiovascular research. Nat Rev Cardiol. 2019 11; 16(11):651-660. PMID: 31570832.
    Citations:    
  24. Liu CL, Zhang X, Liu J, Wang Y, Sukhova GK, Wojtkiewicz GR, Liu T, Tang R, Achilefu S, Nahrendorf M, Libby P, Guo J, Zhang JY, Shi GP. Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis. Nat Commun. 2019 09 04; 10(1):3978. PMID: 31484936.
    Citations:    
  25. Binderup T, Duivenvoorden R, Fay F, van Leent MMT, Malkus J, Baxter S, Ishino S, Zhao Y, Sanchez-Gaytan B, Teunissen AJP, Frederico YCA, Tang J, Carlucci G, Lyashchenko S, Calcagno C, Karakatsanis N, Soultanidis G, Senders ML, Robson PM, Mani V, Ramachandran S, Lobatto ME, Hutten BA, Granada JF, Reiner T, Swirski FK, Nahrendorf M, Kjaer A, Fisher EA, Fayad ZA, Pérez-Medina C, Mulder WJM. Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species. Sci Transl Med. 2019 08 21; 11(506). PMID: 31434756.
    Citations:    
  26. Rohde D, Nahrendorf M. Clonal and diverse: revisiting cardiac endothelial cells after myocardial infarction. Eur Heart J. 2019 08 07; 40(30):2521-2522. PMID: 31162523.
    Citations:    
  27. Vromman A, Ruvkun V, Shvartz E, Wojtkiewicz G, Santos Masson G, Tesmenitsky Y, Folco E, Gram H, Nahrendorf M, Swirski FK, Sukhova GK, Libby P. Stage-dependent differential effects of interleukin-1 isoforms on experimental atherosclerosis. Eur Heart J. 2019 08 07; 40(30):2482-2491. PMID: 30698710.
    Citations:    Fields:    
  28. Severe N, Karabacak NM, Gustafsson K, Baryawno N, Courties G, Kfoury Y, Kokkaliaris KD, Rhee C, Lee D, Scadden EW, Garcia-Robledo JE, Brouse T, Nahrendorf M, Toner M, Scadden DT. Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping. Cell Stem Cell. 2019 Oct 03; 25(4):570-583.e7. PMID: 31279774.
    Citations:    
  29. Tawakol A, Osborne MT, Wang Y, Hammed B, Tung B, Patrich T, Oberfeld B, Ishai A, Shin LM, Nahrendorf M, Warner ET, Wasfy J, Fayad ZA, Koenen K, Ridker PM, Pitman RK, Armstrong KA. Stress-Associated Neurobiological Pathway Linking Socioeconomic Disparities to Cardiovascular Disease. J Am Coll Cardiol. 2019 07 02; 73(25):3243-3255. PMID: 31248544.
    Citations:    
  30. Hulsmans M, Nahrendorf M. Smad3 Cranks Up the Appetite of Infarct Macrophages. Circ Res. 2019 06 21; 125(1):71-73. PMID: 31219739.
    Citations:    
  31. Ferraro B, Leoni G, Hinkel R, Ormanns S, Paulin N, Ortega-Gomez A, Viola JR, de Jong R, Bongiovanni D, Bozoglu T, Maas SL, D'Amico M, Kessler T, Zeller T, Hristov M, Reutelingsperger C, Sager HB, Döring Y, Nahrendorf M, Kupatt C, Soehnlein O. Pro-Angiogenic Macrophage Phenotype to Promote Myocardial Repair. J Am Coll Cardiol. 2019 06 18; 73(23):2990-3002. PMID: 31196457.
    Citations:    
  32. Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW. An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo. Proc Natl Acad Sci U S A. 2019 06 11; 116(24):11966-11971. PMID: 31123149.
    Citations:    
  33. Courties G, Frodermann V, Honold L, Zheng Y, Herisson F, Schloss MJ, Sun Y, Presumey J, Severe N, Engblom C, Hulsmans M, Cremer S, Rohde D, Pittet MJ, Scadden DT, Swirski FK, Kim DE, Moskowitz MA, Nahrendorf M. Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke. Circ Res. 2019 04 26; 124(9):1372-1385. PMID: 30782088.
    Citations:    
  34. McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, Kahles F, Poller WC, Frodermann V, Fenn AM, Gregory AF, Halle L, Iwamoto Y, Hoyer FF, Binder CJ, Libby P, Tafti M, Scammell TE, Nahrendorf M, Swirski FK. Sleep modulates haematopoiesis and protects against atherosclerosis. Nature. 2019 02; 566(7744):383-387. PMID: 30760925.
    Citations:    
  35. He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK. Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease. Nature. 2019 02; 566(7742):115-119. PMID: 30700910.
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  36. Anzai A, Mindur JE, Halle L, Sano S, Choi JL, He S, McAlpine CS, Chan CT, Kahles F, Valet C, Fenn AM, Nairz M, Rattik S, Iwamoto Y, Fairweather D, Walsh K, Libby P, Nahrendorf M, Swirski FK. Self-reactive CD4+ IL-3+ T cells amplify autoimmune inflammation in myocarditis by inciting monocyte chemotaxis. J Exp Med. 2019 02 04; 216(2):369-383. PMID: 30670465.
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  37. Ahmed MS, Rodell CB, Hulsmans M, Kohler RH, Aguirre AD, Nahrendorf M, Weissleder R. A Supramolecular Nanocarrier for Delivery of Amiodarone Anti-Arrhythmic Therapy to the Heart. Bioconjug Chem. 2019 03 20; 30(3):733-740. PMID: 30615425.
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  38. Hoyer FF, Nahrendorf M. Uremic Toxins Activate Macrophages. Circulation. 2019 01 02; 139(1):97-100. PMID: 30592654.
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  39. Swirski FK, Nahrendorf M. Reply to 'Cardioimmunology of arrhythmias: the role of autoimmune and inflammatory cardiac channelopathies'. Nat Rev Immunol. 2019 01; 19(1):65. PMID: 30552386.
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  40. Duivenvoorden R, Senders ML, van Leent MMT, Pérez-Medina C, Nahrendorf M, Fayad ZA, Mulder WJM. Nanoimmunotherapy to treat ischaemic heart disease. Nat Rev Cardiol. 2019 01; 16(1):21-32. PMID: 30209355.
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  41. Nahrendorf M. Myeloid cells in cardiovascular organs. J Intern Med. 2019 05; 285(5):491-502. PMID: 30585362.
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  42. Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet MJ, Nahrendorf M, Weissleder R, Miller MA. Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin. ACS Nano. 2018 12 26; 12(12):12015-12029. PMID: 30508377.
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  43. Hsue PY, Li D, Ma Y, Ishai A, Manion M, Nahrendorf M, Ganz P, Ridker PM, Deeks SG, Tawakol A. IL-1ß Inhibition Reduces Atherosclerotic Inflammation in HIV Infection. J Am Coll Cardiol. 2018 12 04; 72(22):2809-2811. PMID: 30497570.
    Citations:    
  44. Swirski FK, Nahrendorf M. Cardioimmunology: the immune system in cardiac homeostasis and disease. Nat Rev Immunol. 2018 12; 18(12):733-744. PMID: 30228378.
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  45. Nahrendorf M. Multiorgan Imaging of Comorbidity and Cardiovascular Risk. JACC Cardiovasc Imaging. 2020 Feb; 13(2 Pt 1):478-480. PMID: 30448129.
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  46. Hulsmans M, Aguirre AD, Bonner MD, Bapat A, Cremer S, Iwamoto Y, King KR, Swirski FK, Milan DJ, Weissleder R, Nahrendorf M. A Miniaturized, Programmable Pacemaker for Long-Term Studies in the Mouse. Circ Res. 2018 11 09; 123(11):1208-1219. PMID: 30571465.
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  47. Braza MS, van Leent MMT, Lameijer M, Sanchez-Gaytan BL, Arts RJW, Pérez-Medina C, Conde P, Garcia MR, Gonzalez-Perez M, Brahmachary M, Fay F, Kluza E, Kossatz S, Dress RJ, Salem F, Rialdi A, Reiner T, Boros P, Strijkers GJ, Calcagno CC, Ginhoux F, Marazzi I, Lutgens E, Nicolaes GAF, Weber C, Swirski FK, Nahrendorf M, Fisher EA, Duivenvoorden R, Fayad ZA, Netea MG, Mulder WJM, Ochando J. Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance. Immunity. 2018 11 20; 49(5):819-828.e6. PMID: 30413362.
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  48. Hoogeveen RM, Nahrendorf M, Riksen NP, Netea MG, de Winther MPJ, Lutgens E, Nordestgaard BG, Neidhart M, Stroes ESG, Catapano AL, Bekkering S. Monocyte and haematopoietic progenitor reprogramming as common mechanism underlying chronic inflammatory and cardiovascular diseases. Eur Heart J. 2018 10 07; 39(38):3521-3527. PMID: 29069365.
    Citations: 1     Fields:    
  49. Frodermann V, Nahrendorf M. Macrophages and Cardiovascular Health. Physiol Rev. 2018 10 01; 98(4):2523-2569. PMID: 30156496.
    Citations:    Fields:    Translation:HumansAnimalsCells
  50. Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Masson GS, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M. Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci. 2018 09; 21(9):1209-1217. PMID: 30150661.
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  51. Schloss MJ, Nahrendorf M. Some Macrophages Are Softies. Immunity. 2018 08 21; 49(2):199-201. PMID: 30134196.
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  52. Vandoorne K, Rohde D, Kim HY, Courties G, Wojtkiewicz G, Honold L, Hoyer FF, Frodermann V, Nayar R, Herisson F, Jung Y, Désogère PA, Vinegoni C, Caravan P, Weissleder R, Sosnovik DE, Lin CP, Swirski FK, Nahrendorf M. Imaging the Vascular Bone Marrow Niche During Inflammatory Stress. Circ Res. 2018 08 03; 123(4):415-427. PMID: 29980569.
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  53. Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R. Author Correction: Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates. Nat Biomed Eng. 2018 Aug; 2(8):623. PMID: 31015637.
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  54. Bajpai G, Schneider C, Wong N, Bredemeyer A, Hulsmans M, Nahrendorf M, Epelman S, Kreisel D, Liu Y, Itoh A, Shankar TS, Selzman CH, Drakos SG, Lavine KJ. The human heart contains distinct macrophage subsets with divergent origins and functions. Nat Med. 2018 08; 24(8):1234-1245. PMID: 29892064.
    Citations: 3     Fields:    
  55. Cremer S, Nahrendorf M. Myeloid Cells Remodel the Mitral Valve. Circulation. 2018 06 05; 137(23):2494-2496. PMID: 29866774.
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  56. Nahrendorf M. Myeloid cell contributions to cardiovascular health and disease. Nat Med. 2018 06; 24(6):711-720. PMID: 29867229.
    Citations: 2     Fields:    
  57. Lameijer M, Binderup T, van Leent MMT, Senders ML, Fay F, Malkus J, Sanchez-Gaytan BL, Teunissen AJP, Karakatsanis N, Robson P, Zhou X, Ye Y, Wojtkiewicz G, Tang J, Seijkens TTP, Kroon J, Stroes ESG, Kjaer A, Ochando J, Reiner T, Pérez-Medina C, Calcagno C, Fisher EA, Zhang B, Temel RE, Swirski FK, Nahrendorf M, Fayad ZA, Lutgens E, Mulder WJM, Duivenvoorden R. Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates. Nat Biomed Eng. 2018 05; 2(5):279-292. PMID: 30936448.
    Citations:    
  58. Verweij SL, Duivenvoorden R, Stiekema LCA, Nurmohamed NS, van der Valk FM, Versloot M, Verberne HJ, Stroes ESG, Nahrendorf M, Bekkering S, Bernelot Moens SJ. CCR2 expression on circulating monocytes is associated with arterial wall inflammation assessed by 18F-FDG PET/CT in patients at risk for cardiovascular disease. Cardiovasc Res. 2018 Mar 01; 114(3):468-475. PMID: 29186373.
    Citations: 1     Fields:    
  59. Swirski FK, Nahrendorf M. Clonal Hematopoiesis Wages War on the Myocardium. J Am Coll Cardiol. 2018 02 27; 71(8):887-889. PMID: 29471940.
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  60. Brannen A, Eggert M, Nahrendorf M, Arnold R, Panizzi P. Correlation of 360-degree Surface Mapping In Vivo Bioluminescence with Multi-Spectral Optoacoustic Tomography in Human Xenograft Tumor Models. Sci Rep. 2018 02 20; 8(1):3321. PMID: 29463820.
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  61. Nahrendorf M, Vandoorne K. Albumin-Binding MR Probe Detects High-Risk Coronary Plaques in Patients. JACC Cardiovasc Imaging. 2019 02; 12(2):307-309. PMID: 29361477.
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  62. Hulsmans M, Sager HB, Roh JD, Valero-Muñoz M, Houstis NE, Iwamoto Y, Sun Y, Wilson RM, Wojtkiewicz G, Tricot B, Osborne MT, Hung J, Vinegoni C, Naxerova K, Sosnovik DE, Zile MR, Bradshaw AD, Liao R, Tawakol A, Weissleder R, Rosenzweig A, Swirski FK, Sam F, Nahrendorf M. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018 02 05; 215(2):423-440. PMID: 29339450.
    Citations: 6     Fields:    
  63. Honold L, Nahrendorf M. Resident and Monocyte-Derived Macrophages in Cardiovascular Disease. Circ Res. 2018 01 05; 122(1):113-127. PMID: 29301844.
    Citations: 3     Fields:    
  64. Ryu WS, Bae EK, Park SH, Jeong SW, Schellingerhout D, Nahrendorf M, Kim DE. Increased Left Ventricular Filling Pressure and Arterial Occlusion in Stroke Related to Atrial Fibrillation. J Stroke Cerebrovasc Dis. 2018 May; 27(5):1275-1282. PMID: 29310958.
    Citations:    Fields:    Translation:Humans
  65. Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science. 2017 12 01; 358(6367). PMID: 29191879.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  66. Stiekema LCA, Schnitzler JG, Nahrendorf M, Stroes ESG. The maturation of a 'neural-hematopoietic' inflammatory axis in cardiovascular disease. Curr Opin Lipidol. 2017 Dec; 28(6):507-512. PMID: 28877089.
    Citations: 1     Fields:    Translation:HumansAnimals
  67. Pérez-Medina C, Hak S, Reiner T, Fayad ZA, Nahrendorf M, Mulder WJM. Integrating nanomedicine and imaging. Philos Trans A Math Phys Eng Sci. 2017 Nov 28; 375(2107). PMID: 29038380.
    Citations:    Fields:    
  68. King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R. IRF3 and type I interferons fuel a fatal response to myocardial infarction. Nat Med. 2017 Dec; 23(12):1481-1487. PMID: 29106401.
    Citations: 12     Fields:    Translation:AnimalsCells
  69. Anzai A, Choi JL, He S, Fenn AM, Nairz M, Rattik S, McAlpine CS, Mindur JE, Chan CT, Iwamoto Y, Tricot B, Wojtkiewicz GR, Weissleder R, Libby P, Nahrendorf M, Stone JR, Becher B, Swirski FK. The infarcted myocardium solicits GM-CSF for the detrimental oversupply of inflammatory leukocytes. J Exp Med. 2017 Nov 06; 214(11):3293-3310. PMID: 28978634.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  70. Teague HL, Ahlman MA, Alavi A, Wagner DD, Lichtman AH, Nahrendorf M, Swirski FK, Nestle F, Gelfand JM, Kaplan MJ, Grinspoon S, Ridker PM, Newby DE, Tawakol A, Fayad ZA, Mehta NN. Unraveling Vascular Inflammation: From Immunology to Imaging. J Am Coll Cardiol. 2017 Sep 12; 70(11):1403-1412. PMID: 28882238.
    Citations: 4     Fields:    Translation:Humans
  71. Shon SM, Jang HJ, Schellingerhout D, Kim JY, Ryu WS, Lee SK, Kim J, Park JY, Oh JH, Kang JW, Je KH, Park JE, Kim K, Kwon IC, Lee J, Nahrendorf M, Park JH, Kim DE. Cytokine Response to Diet and Exercise Affects Atheromatous Matrix Metalloproteinase-2/9 Activity in Mice. Circ J. 2017 Sep 25; 81(10):1528-1536. PMID: 28883215.
    Citations:    Fields:    Translation:Animals
  72. Meyer IS, Jungmann A, Dieterich C, Zhang M, Lasitschka F, Werkmeister S, Haas J, Müller OJ, Boutros M, Nahrendorf M, Katus HA, Hardt SE, Leuschner F. The cardiac microenvironment uses non-canonical WNT signaling to activate monocytes after myocardial infarction. EMBO Mol Med. 2017 09; 9(9):1279-1293. PMID: 28774883.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  73. Nahrendorf M, Swirski FK. Cholesterol, CCR2, and monocyte phenotypes in atherosclerosis. Eur Heart J. 2017 05 21; 38(20):1594-1596. PMID: 28329093.
    Citations:    Fields:    
  74. Alaarg A, Pérez-Medina C, Metselaar JM, Nahrendorf M, Fayad ZA, Storm G, Mulder WJM. Applying nanomedicine in maladaptive inflammation and angiogenesis. Adv Drug Deliv Rev. 2017 09 15; 119:143-158. PMID: 28506745.
    Citations: 1     Fields:    Translation:HumansAnimals
  75. Kim DE, Kim JY, Schellingerhout D, Ryu JH, Lee SK, Jeon S, Lee JS, Kim J, Jang HJ, Park JE, Kim EJ, Kwon IC, Ahn CH, Nahrendorf M, Kim K. Quantitative Imaging of Cerebral Thromboemboli In Vivo: The Effects of Tissue-Type Plasminogen Activator. Stroke. 2017 05; 48(5):1376-1385. PMID: 28432262.
    Citations: 1     Fields:    Translation:Animals
  76. Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P. Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion. Circ Res. 2017 Jun 23; 121(1):31-42. PMID: 28428204.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  77. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017 04 20; 169(3):510-522.e20. PMID: 28431249.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  78. Vandoorne K, Nahrendorf M. Multiparametric Imaging of Organ System Interfaces. Circ Cardiovasc Imaging. 2017 Apr; 10(4). PMID: 28360260.
    Citations:    Fields:    Translation:HumansAnimals
  79. Swirski FK, Nahrendorf M. Inflammation: Old, caffeinated, and healthy. Nat Rev Cardiol. 2017 04; 14(4):194-196. PMID: 28250451.
    Citations: 1     Fields:    Translation:Humans
  80. Lee S, Courties G, Nahrendorf M, Weissleder R, Vinegoni C. Motion characterization scheme to minimize motion artifacts in intravital microscopy. J Biomed Opt. 2017 03 01; 22(3):36005. PMID: 28253383.
    Citations:    Fields:    Translation:Humans
  81. Hoyer FF, Nahrendorf M. Neutrophil contributions to ischaemic heart disease. Eur Heart J. 2017 02 14; 38(7):465-472. PMID: 28363210.
    Citations: 1     Fields:    
  82. van der Valk FM, Kuijk C, Verweij SL, Stiekema LCA, Kaiser Y, Zeerleder S, Nahrendorf M, Voermans C, Stroes ESG. Increased haematopoietic activity in patients with atherosclerosis. Eur Heart J. 2017 02 07; 38(6):425-432. PMID: 27357356.
    Citations: 5     Fields:    Translation:HumansCells
  83. Je KH, Ryu WS, Lee SK, Kim EJ, Kim JY, Jang HJ, Park JE, Nahrendorf M, Schellingerhout D, Kim DE. Green-channel autofluorescence imaging: A novel and sensitive technique to delineate infarcts. J Neurosci Methods. 2017 03 01; 279:22-32. PMID: 28104485.
    Citations:    Fields:    Translation:Animals
  84. Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M. Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun. 2017 01 16; 8:14064. PMID: 28091604.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  85. Frodermann V, Nahrendorf M. Neutrophil-macrophage cross-talk in acute myocardial infarction. Eur Heart J. 2017 01 14; 38(3):198-200. PMID: 28158564.
    Citations: 8     Fields:    Translation:HumansCells
  86. Tawakol A, Ishai A, Takx RA, Figueroa AL, Ali A, Kaiser Y, Truong QA, Solomon CJ, Calcagno C, Mani V, Tang CY, Mulder WJ, Murrough JW, Hoffmann U, Nahrendorf M, Shin LM, Fayad ZA, Pitman RK. Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study. Lancet. 2017 02 25; 389(10071):834-845. PMID: 28088338.
    Citations: 25     Fields:    Translation:Humans
  87. Ali M, Pulli B, Courties G, Tricot B, Sebas M, Iwamoto Y, Hilgendorf I, Schob S, Dong A, Zheng W, Skoura A, Kalgukar A, Cortes C, Ruggeri R, Swirski FK, Nahrendorf M, Buckbinder L, Chen JW. Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction. JACC Basic Transl Sci. 2016 Dec; 1(7):633-643. PMID: 30167547.
    Citations:    
  88. Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJ. Immune cell screening of a nanoparticle library improves atherosclerosis therapy. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):E6731-E6740. PMID: 27791119.
    Citations: 4     Fields:    Translation:AnimalsCells
  89. Kim J, Park JE, Nahrendorf M, Kim DE. Direct Thrombus Imaging in Stroke. J Stroke. 2016 Sep; 18(3):286-296. PMID: 27733029.
    Citations: 6     
  90. Swirski FK, Nahrendorf M. Bone Marrow Takes Center Stage in Cardiovascular Disease. Circ Res. 2016 09 02; 119(6):701-3. PMID: 27587406.
    Citations:    Fields:    Translation:HumansCells
  91. Swirski FK, Nahrendorf M, Libby P. Mechanisms of Myeloid Cell Modulation of Atherosclerosis. Microbiol Spectr. 2016 08; 4(4). PMID: 27726819.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  92. Dutta P, Hoyer FF, Sun Y, Iwamoto Y, Tricot B, Weissleder R, Magnani JL, Swirski FK, Nahrendorf M. E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1802-8. PMID: 27470513.
    Citations: 4     Fields:    Translation:AnimalsCells
  93. Libby P, Nahrendorf M, Swirski FK. Reply: The Networks Between the Sympathetic Nervous System and Immune System in Atherosclerosis. J Am Coll Cardiol. 2016 07 26; 68(4):432. PMID: 27443446.
    Citations:    Fields:    Translation:Humans
  94. Pinciroli R, Mietto C, Piriyapatsom A, Chenelle CT, Thomas JG, Pirrone M, Bry L, Wojtkiewicz GR, Nahrendorf MP, Kacmarek RM, Berra L. Endotracheal Tubes Cleaned With a Novel Mechanism for Secretion Removal: A Randomized Controlled Clinical Study. Respir Care. 2016 Nov; 61(11):1431-1439. PMID: 27460104.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  95. Nahrendorf M, Swirski FK. Abandoning M1/M2 for a Network Model of Macrophage Function. Circ Res. 2016 07 22; 119(3):414-7. PMID: 27458196.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  96. Sager HB, Hulsmans M, Lavine KJ, Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure. Circ Res. 2016 Sep 16; 119(7):853-64. PMID: 27444755.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  97. Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK. On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat Med. 2016 08; 22(8):945-51. PMID: 27428900.
    Citations: 35     Fields:    Translation:AnimalsCells
  98. Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M. RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction. Sci Transl Med. 2016 06 08; 8(342):342ra80. PMID: 27280687.
    Citations: 23     Fields:    Translation:AnimalsCells
  99. Sager HB, Nahrendorf M. Inflammation: a trigger for acute coronary syndrome. Q J Nucl Med Mol Imaging. 2016 Sep; 60(3):185-93. PMID: 27273431.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  100. Ryu WS, Schellingerhout D, Jeong SW, Nahrendorf M, Kim DE. Association between Serum Lipid Profiles and Early Neurological Deterioration in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2016 Aug; 25(8):2024-30. PMID: 27256172.
    Citations:    Fields:    Translation:Humans
  101. Rischpler C, Dirschinger RJ, Nekolla SG, Kossmann H, Nicolosi S, Hanus F, van Marwick S, Kunze KP, Meinicke A, Götze K, Kastrati A, Langwieser N, Ibrahim T, Nahrendorf M, Schwaiger M, Laugwitz KL. Prospective Evaluation of 18F-Fluorodeoxyglucose Uptake in Postischemic Myocardium by Simultaneous Positron Emission Tomography/Magnetic Resonance Imaging as a Prognostic Marker of Functional Outcome. Circ Cardiovasc Imaging. 2016 Apr; 9(4):e004316. PMID: 27056601.
    Citations: 15     Fields:    Translation:Humans
  102. Frodermann V, Nahrendorf M. Neutrophil-macrophage cross-talk in acute myocardial infarction. Eur Heart J. 2016 Mar 16. PMID: 26984866.
    Citations:    
  103. Libby P, Nahrendorf M, Swirski FK. Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum". J Am Coll Cardiol. 2016 Mar 08; 67(9):1091-1103. PMID: 26940931.
    Citations: 30     Fields:    Translation:HumansCells
  104. Davis RW, Brannen AD, Hossain MJ, Monsma S, Bock PE, Nahrendorf M, Mead D, Lodes M, Liles MR, Panizzi P. Complete genome of Staphylococcus aureus Tager 104 provides evidence of its relation to modern systemic hospital-acquired strains. BMC Genomics. 2016 Mar 03; 17:179. PMID: 26940863.
    Citations:    Fields:    Translation:HumansAnimalsCells
  105. Calcagno C, Mulder WJ, Nahrendorf M, Fayad ZA. Systems Biology and Noninvasive Imaging of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016 Feb; 36(2):e1-8. PMID: 26819466.
    Citations: 3     Fields:    Translation:HumansAnimals
  106. Valero-Muñoz M, Li S, Wilson RM, Hulsmans M, Aprahamian T, Fuster JJ, Nahrendorf M, Scherer PE, Sam F. Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue. Circ Heart Fail. 2016 Jan; 9(1):e002724. PMID: 26721917.
    Citations: 10     Fields:    Translation:AnimalsCells
  107. Swirski FK, Robbins CS, Nahrendorf M. Development and Function of Arterial and Cardiac Macrophages. Trends Immunol. 2016 Jan; 37(1):32-40. PMID: 26748179.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  108. Nahrendorf M, Swirski FK. PET Imaging of Leukocytes in Patients With Acute Myocardial Infarction. JACC Cardiovasc Imaging. 2015 Dec; 8(12):1427-1429. PMID: 26699111.
    Citations: 1     Fields:    Translation:HumansCells
  109. Davis RW, Eggleston H, Johnson F, Nahrendorf M, Bock PE, Peterson T, Panizzi P. In Vivo Tracking of Streptococcal Infections of Subcutaneous Origin in a Murine Model. Mol Imaging Biol. 2015 Dec; 17(6):793-801. PMID: 25921659.
    Citations:    Fields:    Translation:AnimalsCells
  110. Weissleder R, Nahrendorf M. Advancing biomedical imaging. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14424-8. PMID: 26598657.
    Citations: 14     Fields:    Translation:HumansAnimals
  111. Hulsmans M, Sam F, Nahrendorf M. Monocyte and macrophage contributions to cardiac remodeling. J Mol Cell Cardiol. 2016 04; 93:149-55. PMID: 26593722.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  112. Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, Sena BF, Kim J, Goichberg P, Nahrendorf M, Isom LL, Leri A, Anversa P, Rota M. Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy. Nat Commun. 2015 Nov 06; 6:8803. PMID: 26541940.
    Citations: 14     Fields:    Translation:AnimalsCells
  113. Joseph P, Ishai A, MacNabb M, Abdelbaky A, Lavender ZR, Ruskin J, Nahrendorf M, Tawakol A. Atrial fibrillation is associated with hematopoietic tissue activation and arterial inflammation. Int J Cardiovasc Imaging. 2016 Jan; 32(1):113-9. PMID: 26411879.
    Citations: 5     Fields:    Translation:Humans
  114. Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJ, Nahrendorf M. Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis. Circ Res. 2015 Oct 23; 117(10):835-45. PMID: 26394773.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  115. Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Targeting Interleukin-1ß Reduces Leukocyte Production After Acute Myocardial Infarction. Circulation. 2015 Nov 17; 132(20):1880-90. PMID: 26358260.
    Citations: 33     Fields:    Translation:AnimalsCells
  116. Nahrendorf M, Swirski FK. Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction? Eur Heart J. 2016 Mar 14; 37(11):868-72. PMID: 26351395.
    Citations: 15     Fields:    Translation:HumansCells
  117. Gonçalves I, den Ruijter H, Nahrendorf M, Pasterkamp G. Detecting the vulnerable plaque in patients. J Intern Med. 2015 Nov; 278(5):520-30. PMID: 26306911.
    Citations: 2     Fields:    Translation:Humans
  118. Nahrendorf M, Dutta P. Targeting splenic hematopoietic stem cells in cardiovascular disease. Oncotarget. 2015 Aug 21; 6(24):19918-9. PMID: 26343366.
    Citations:    Fields:    Translation:HumansCells
  119. He S, Chousterman BG, Fenn A, Anzai A, Nairz M, Brandt M, Hilgendorf I, Sun Y, Ye YX, Iwamoto Y, Tricot B, Weissleder R, Macphee C, Libby P, Nahrendorf M, Swirski FK. Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages. Circ Heart Fail. 2015 Sep; 8(5):980-7. PMID: 26232205.
    Citations: 2     Fields:    Translation:AnimalsCells
  120. Nahrendorf M, Swirski FK. Immunology. Neutrophil-macrophage communication in inflammation and atherosclerosis. Science. 2015 Jul 17; 349(6245):237-8. PMID: 26185231.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  121. Kim JY, Ryu JH, Schellingerhout D, Sun IC, Lee SK, Jeon S, Kim J, Kwon IC, Nahrendorf M, Ahn CH, Kim K, Kim DE. Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles. Theranostics. 2015; 5(10):1098-114. PMID: 26199648.
    Citations: 8     Fields:    Translation:HumansAnimals
  122. Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M. Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell Stem Cell. 2015 May 07; 16(5):477-87. PMID: 25957903.
    Citations: 31     Fields:    Translation:AnimalsCells
  123. Nahrendorf M, Frantz S, Swirski FK, Mulder WJ, Randolph G, Ertl G, Ntziachristos V, Piek JJ, Stroes ES, Schwaiger M, Mann DL, Fayad ZA. Imaging systemic inflammatory networks in ischemic heart disease. J Am Coll Cardiol. 2015 Apr 21; 65(15):1583-91. PMID: 25881940.
    Citations: 16     Fields:    Translation:HumansCells
  124. Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Cell Metab. 2015 Apr 07; 21(4):609-21. PMID: 25863250.
    Citations: 19     Fields:    Translation:AnimalsCells
  125. Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager H, Astudillo YM, Leong W, Ramachandran S, Storm G, Pérez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ES, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJ. Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation. Sci Adv. 2015 Apr; 1(3). PMID: 26295063.
    Citations: 24     Fields:    
  126. Dutta P, Hoyer FF, Grigoryeva LS, Sager HB, Leuschner F, Courties G, Borodovsky A, Novobrantseva T, Ruda VM, Fitzgerald K, Iwamoto Y, Wojtkiewicz G, Sun Y, Da Silva N, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. J Exp Med. 2015 Apr 06; 212(4):497-512. PMID: 25800955.
    Citations: 28     Fields:    Translation:AnimalsCells
  127. Dutta P, Nahrendorf M. Monocytes in myocardial infarction. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1066-70. PMID: 25792449.
    Citations: 32     Fields:    Translation:HumansCells
  128. Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK. Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science. 2015 Mar 13; 347(6227):1260-5. PMID: 25766237.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  129. Nahrendorf M, Swirski FK. Lifestyle effects on hematopoiesis and atherosclerosis. Circ Res. 2015 Feb 27; 116(5):884-94. PMID: 25722442.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  130. Emami H, Singh P, MacNabb M, Vucic E, Lavender Z, Rudd JH, Fayad ZA, Lehrer-Graiwer J, Korsgren M, Figueroa AL, Fredrickson J, Rubin B, Hoffmann U, Truong QA, Min JK, Baruch A, Nasir K, Nahrendorf M, Tawakol A. Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans. JACC Cardiovasc Imaging. 2015 Feb; 8(2):121-30. PMID: 25577441.
    Citations: 37     Fields:    Translation:Humans
  131. Mietto C, Pinciroli R, Piriyapatsom A, Thomas JG, Bry L, Delaney ML, Du Bois A, Truelove J, Ackman JB, Wojtkiewicz GR, Nahrendorf M, Kacmarek RM, Berra L. Tracheal tube obstruction in mechanically ventilated patients assessed by high-resolution computed tomography. Anesthesiology. 2014 Dec; 121(6):1226-35. PMID: 25254903.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  132. Dutta P, Nahrendorf M. Regulation and consequences of monocytosis. Immunol Rev. 2014 Nov; 262(1):167-78. PMID: 25319334.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  133. Courties G, Herisson F, Sager HB, Heidt T, Ye Y, Wei Y, Sun Y, Severe N, Dutta P, Scharff J, Scadden DT, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M. Ischemic stroke activates hematopoietic bone marrow stem cells. Circ Res. 2015 Jan 30; 116(3):407-17. PMID: 25362208.
    Citations: 32     Fields:    Translation:AnimalsCells
  134. Swirski FK, Nahrendorf M. Do vascular smooth muscle cells differentiate to macrophages in atherosclerotic lesions? Circ Res. 2014 Sep 12; 115(7):605-6. PMID: 25214571.
    Citations: 7     Fields:    Translation:AnimalsCells
  135. Taqueti VR, Nahrendorf M, Di Carli MF. Translational molecular imaging: repurposing an old technique to track cell migration into human atheroma. J Am Coll Cardiol. 2014 Sep 09; 64(10):1030-2. PMID: 25190239.
    Citations: 1     Fields:    Translation:HumansCells
  136. Nahrendorf M, Swirski FK. Imaging systemic inflammation in patients with acute myocardial infarction. Circ Cardiovasc Imaging. 2014 Sep; 7(5):762-4. PMID: 25227235.
    Citations:    Fields:    Translation:Humans
  137. Taqueti VR, Di Carli MF, Jerosch-Herold M, Sukhova GK, Murthy VL, Folco EJ, Kwong RY, Ozaki CK, Belkin M, Nahrendorf M, Weissleder R, Libby P. Increased microvascularization and vessel permeability associate with active inflammation in human atheromata. Circ Cardiovasc Imaging. 2014 Nov; 7(6):920-9. PMID: 25170063.
    Citations: 16     Fields:    Translation:HumansCells
  138. Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M. Chronic variable stress activates hematopoietic stem cells. Nat Med. 2014 Jul; 20(7):754-758. PMID: 24952646.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  139. Nahrendorf M, Swirski FK. Regulating repair: regulatory T cells in myocardial infarction. Circ Res. 2014 Jun 20; 115(1):7-9. PMID: 24951758.
    Citations: 1     Fields:    Translation:AnimalsCells
  140. Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M. Silencing of CCR2 in myocarditis. Eur Heart J. 2015 Jun 14; 36(23):1478-88. PMID: 24950695.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  141. Mulder WJ, Jaffer FA, Fayad ZA, Nahrendorf M. Imaging and nanomedicine in inflammatory atherosclerosis. Sci Transl Med. 2014 Jun 04; 6(239):239sr1. PMID: 24898749.
    Citations: 43     Fields:    Translation:HumansAnimals
  142. Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK. Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med. 2014 Jun 02; 211(6):1243-56. PMID: 24821911.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  143. Dahlman JE, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Sandu KS, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AKR, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Schroeder A, Panigrahy D, Kotelianski V, Langer R, Anderson DG. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nat Nanotechnol. 2014 Aug; 9(8):648-655. PMID: 24813696.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  144. Panizzi P, Stone JR, Nahrendorf M. Endocarditis and molecular imaging. J Nucl Cardiol. 2014 Jun; 21(3):486-95. PMID: 24797384.
    Citations: 1     Fields:    Translation:Humans
  145. Heidt T, Courties G, Dutta P, Sager HB, Sebas M, Iwamoto Y, Sun Y, Da Silva N, Panizzi P, van der Laan AM, van der Lahn AM, Swirski FK, Weissleder R, Nahrendorf M. Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction. Circ Res. 2014 Jul 07; 115(2):284-95. PMID: 24786973.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  146. Pittet MJ, Nahrendorf M, Swirski FK. The journey from stem cell to macrophage. Ann N Y Acad Sci. 2014 Jun; 1319:1-18. PMID: 24673186.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  147. Hilgendorf I, Gerhardt LM, Tan TC, Winter C, Holderried TA, Chousterman BG, Iwamoto Y, Liao R, Zirlik A, Scherer-Crosbie M, Hedrick CC, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium. Circ Res. 2014 May 09; 114(10):1611-22. PMID: 24625784.
    Citations: 101     Fields:    Translation:AnimalsCells
  148. Nahrendorf M, Swirski FK. Fluorescent leukocytes enter plaque on the microscope stage. Circ Res. 2014 Feb 28; 114(5):740-1. PMID: 24577957.
    Citations:    Fields:    Translation:Animals
  149. Frantz S, Nahrendorf M. Cardiac macrophages and their role in ischaemic heart disease. Cardiovasc Res. 2014 May 01; 102(2):240-8. PMID: 24501331.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  150. Courties G, Moskowitz MA, Nahrendorf M. The innate immune system after ischemic injury: lessons to be learned from the heart and brain. JAMA Neurol. 2014 Feb; 71(2):233-6. PMID: 24296962.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  151. Weissleder R, Nahrendorf M, Pittet MJ. Imaging macrophages with nanoparticles. Nat Mater. 2014 Feb; 13(2):125-38. PMID: 24452356.
    Citations: 107     Fields:    Translation:HumansCells
  152. Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation. 2014 Apr 22; 129(16):1677-87. PMID: 24488984.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  153. Duivenvoorden R, Tang J, Cormode DP, Mieszawska AJ, Izquierdo-Garcia D, Ozcan C, Otten MJ, Zaidi N, Lobatto ME, van Rijs SM, Priem B, Kuan EL, Martel C, Hewing B, Sager H, Nahrendorf M, Randolph GJ, Stroes ES, Fuster V, Fisher EA, Fayad ZA, Mulder WJ. A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation. Nat Commun. 2014; 5:3065. PMID: 24445279.
    Citations: 59     Fields:    Translation:Animals
  154. Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, Tricot B, Wojtkiewicz G, Dutta P, Sager HB, Borodovsky A, Novobrantseva T, Klebanov B, Fitzgerald K, Anderson DG, Libby P, Swirski FK, Weissleder R, Nahrendorf M. In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing. J Am Coll Cardiol. 2014 Apr 22; 63(15):1556-66. PMID: 24361318.
    Citations: 63     Fields:    Translation:AnimalsCells
  155. Vinegoni C, Lee S, Feruglio PF, Marzola P, Nahrendorf M, Weissleder R. Sequential average segmented microscopy for high signal-to-noise ratio motion-artifact-free in vivo heart imaging. Biomed Opt Express. 2013; 4(10):2095-106. PMID: 24156067.
    Citations: 8     
  156. Zangi L, Lui KO, von Gise A, Ma Q, Ebina W, Ptaszek LM, Später D, Xu H, Tabebordbar M, Gorbatov R, Sena B, Nahrendorf M, Briscoe DM, Li RA, Wagers AJ, Rossi DJ, Pu WT, Chien KR. Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol. 2013 Oct; 31(10):898-907. PMID: 24013197.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  157. Swirski FK, Nahrendorf M. Macrophage-stem cell crosstalk after myocardial infarction. J Am Coll Cardiol. 2013 Nov 12; 62(20):1902-4. PMID: 23973700.
    Citations: