Matthias Nahrendorf, M.D.
Title Professor of Radiology Institution Massachusetts General Hospital Address MGH Ctr for Systems Biology
Simches Research Center, Suite 5.210
185 Cambridge St
Boston MA 02114
|
|
Biography
| University of Heidelberg , Germany | MD | 04/1998 | Medicine |
| Harvard Medical School, Boston, USA | M. Sc. | 04/217 | (Hon) |
2020
Martin Research Prize
2020
Rolf Sammet Guest Professor, Frankfurt University
2020
Endowed Chair, MGH Research Institute
2019
Adjunct Professor of Medicine, Julius-Maximilians-Universität Würzburg
2018
Appointed to NHLBI board of external experts
2017
Chair Atherosclerosis Gordon Research Conference
2015
Basic Research Award, German Society of Cardiology
2014
MGH Research Scholar Award
2013
Member, American Society of Clinical Investigation
Overview
The Nahrendorf laboratory focuses on the role of immunity in cardiovascular health and disease, specifically in atherosclerosis and heart failure. Of particular interest are the function, supply and production of leukocytes, and the signals that regulate hematopoiesis after injuries such as myocardial infarction or stroke. We described that after MI, the spleen releases a large population of ready-made leukocytes that travel to the ischemic heart (Science 2009, New York Times 2009). We further found that MI, chronic stress and sedentary life style modulate the hematopoietic stem cell niche, activating migration and proliferation of myeloid progenitor cells (Nature 2012, Nature Med 2014, Nature Med 2019). Resident macrophages, on the other hand, do not derive from circulating cells and promote steady state functions such as cardiac conduction (Cell 2017). The laboratory also develops and employs imaging to sample biology non-invasively, using MR, nuclear, optical and microscopic modalities.
Research
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
Faculty can
login
to make corrections and additions.
-
P01HL142494
(NAHRENDORF, MATTHIAS)
Aug 1, 2019 - Jul 31, 2024
Hematopoiesis in cardiovascular disease
Role: Principal Investigator
-
R01NS108419
(MOSKOWITZ, MICHAEL A.)
Sep 30, 2018 - Jul 31, 2023
Skull marrow crosstalk with the central nervous system
Role: Co-Principal Investigator
-
R35HL139598
(NAHRENDORF, MATTHIAS)
Feb 1, 2018 - Jan 31, 2025
Imaging organ system interfaces in ischemic heart disease
Role: Principal Investigator
-
R13HL137211
(NAHRENDORF, MATTHIAS)
May 1, 2017 - Apr 30, 2018
2017 Atherosclerosis Gordon Research Conference & Gordon Research Seminar
Role: Principal Investigator
-
R01HL131495
(NAHRENDORF, MATTHIAS)
Feb 1, 2017 - Jan 31, 2021
Quantitative nanoparticle imaging of macrophages
Role: Principal Investigator
-
R01HL125428
(NAHRENDORF, MATTHIAS)
Jan 9, 2017 - Dec 31, 2020
Interfering with the macrophage life cycle of atherosclerosis
Role: Principal Investigator
-
R01HL128264
(SWIRSKI, FILIP K)
Sep 1, 2015 - Jul 31, 2019
Lifestyle effects on hematopoiesis and atherosclerosis
Role: Principal Investigator
-
R01HL118440
(MULDER, WILLEM)
Sep 1, 2014 - Jun 30, 2018
Anti-inflammatory nanoparticle formulations to treat atherosclerosis
Role: Co-Principal Investigator
-
R01NS084863
(NAHRENDORF, MATTHIAS)
Jun 15, 2014 - Apr 30, 2020
Dynamic interactions between ischemic stroke, immunity and the bone marrow
Role: Co-Principal Investigator
-
R01HL117829
(NAHRENDORF, MATTHIAS)
Feb 1, 2014 - Jan 31, 2018
Cell-Cell Interaction in Heart Failure
Role: Principal Investigator
-
R01HL114477
(NAHRENDORF, MATTHIAS)
Jun 15, 2013 - May 31, 2017
Pathogen specific imaging of endocarditis
Role: Principal Investigator
-
P01AG043353
(ANVERSA, PIERO)
Dec 1, 2012 - Nov 30, 2017
Role: Co-Principal Investigator
-
R01HL096576
(NAHRENDORF, MATTHIAS)
Aug 1, 2009 - Nov 30, 2018
PET/MRI of cardiac repair
Role: Principal Investigator
-
R01HL095629
(NAHRENDORF, MATTHIAS)
Jul 15, 2009 - Dec 30, 2014
Imaging of Cardiac Transplant Rejection
Role: Principal Investigator
-
U24CA092782
(WEISSLEDER, RALPH)
Jul 1, 2001 - Jun 30, 2013
Small Animal Imaging Resource
Role: Principal Investigator
-
P50CA086355
(WEISSLEDER, RALPH)
Aug 9, 2000 - Jun 30, 2016
Center for Molecular Imaging Research at MGH/HMS
Role: Co-Principal Investigator
-
P41RR005959
(JOHNSON, GEORGE ALLAN)
Sep 1, 1990 - Jun 30, 2013
Integrated Center for InVivo Microscopy
Role: Co-Principal Investigator
Bibliographic
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.