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profileMatthias Nahrendorf, M.D.

TitleProfessor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital, Ctr for Systems Biology
Richard B. Simches Research Center, Suite 5.210
185 Cambridge St
Boston MA 02114
Phone617/643-0500
Fax617/643-6133
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Collapse Overview 
Collapse overview
My current research interests focus on 1) imaging of molecular processes during the healing phase after myocardial infarction, 2) imaging of heart transplant rejection, and 3) imaging of inflammation in atherosclerotic plaques. Imaging targets are enzymes, innate immune cells and molecular players with a central role in cardiovascular disease. We use the entire spectrum of modalities, including MRI, nuclear and optical imaging techniques. Multimodal imaging, as well as hybrid approaches to fuse molecular data with anatomical information are aspects of particular interest. These technologies are embedded in a biologically driven research program that aims at systematic understanding of inflammation and repair at a basic level while keeping a rigorous translational perspective.


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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01HL128264     (NAHRENDORF, MATTHIAS)Sep 1, 2015 - May 31, 2019
NIH/NHLBI
Lifestyle effects on hematopoiesis and atherosclerosis
Role: Principal Investigator

R01HL118440     (MULDER, WILLEM)Sep 1, 2014 - May 31, 2018
NIH/NHLBI
Anti-inflammatory nanoparticle formulations to treat atherosclerosis
Role: Co-Principal Investigator

R01NS084863     (MOSKOWITZ, MICHAEL A.)Jun 15, 2014 - Apr 30, 2019
NIH/NINDS
Dynamic interactions between ischemic stroke, immunity and the bone marrow
Role: Co-Principal Investigator

R01HL117829     (NAHRENDORF, MATTHIAS)Feb 1, 2014 - Jan 31, 2018
NIH/NHLBI
Cell-Cell Interaction in Heart Failure
Role: Principal Investigator

R01HL114477     (NAHRENDORF, MATTHIAS)Jun 15, 2013 - May 31, 2017
NIH/NHLBI
Pathogen specific imaging of endocarditis
Role: Principal Investigator
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This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Mouse Imaging Program (MGH) - Core services (13) and Instruments (9)

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nahrendorf M, Swirski FK. Cholesterol, CCR2, and monocyte phenotypes in atherosclerosis. Eur Heart J. 2017 May 21; 38(20):1594-1596. PMID: 28329093.
    View in: PubMed
  2. Alaarg A, Pérez-Medina C, Metselaar JM, Nahrendorf M, Fayad ZA, Storm G, Mulder WJM. Applying nanomedicine in maladaptive inflammation and angiogenesis. Adv Drug Deliv Rev. 2017 May 12. PMID: 28506745.
    View in: PubMed
  3. Kim DE, Kim JY, Schellingerhout D, Ryu JH, Lee SK, Jeon S, Lee JS, Kim J, Jang HJ, Park JE, Kim EJ, Kwon IC, Ahn CH, Nahrendorf M, Kim K. Quantitative Imaging of Cerebral Thromboemboli In Vivo: The Effects of Tissue-Type Plasminogen Activator. Stroke. 2017 May; 48(5):1376-1385. PMID: 28432262.
    View in: PubMed
  4. Franck G, Mawson T, Sausen G, Salinas M, Masson GS, Cole A, Beltrami-Moreira M, Chatzizisis Y, Quillard T, Tesmenitsky Y, Shvartz E, Sukhova GK, Swirski FK, Nahrendorf M, Aikawa E, Croce KJ, Libby P. Flow Perturbation Mediates Neutrophil Recruitment and Potentiates Endothelial Injury via TLR2 in Mice: Implications for Superficial Erosion. Circ Res. 2017 Jun 23; 121(1):31-42. PMID: 28428204.
    View in: PubMed
  5. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017 Apr 20; 169(3):510-522.e20. PMID: 28431249.
    View in: PubMed
  6. Vandoorne K, Nahrendorf M. Multiparametric Imaging of Organ System Interfaces. Circ Cardiovasc Imaging. 2017 Apr; 10(4). PMID: 28360260.
    View in: PubMed
  7. Swirski FK, Nahrendorf M. Inflammation: Old, caffeinated, and healthy. Nat Rev Cardiol. 2017 Apr; 14(4):194-196. PMID: 28250451.
    View in: PubMed
  8. Lee S, Courties G, Nahrendorf M, Weissleder R, Vinegoni C. Motion characterization scheme to minimize motion artifacts in intravital microscopy. J Biomed Opt. 2017 Mar 01; 22(3):36005. PMID: 28253383.
    View in: PubMed
  9. Hoyer FF, Nahrendorf M. Neutrophil contributions to ischaemic heart disease. Eur Heart J. 2017 Feb 14; 38(7):465-472. PMID: 28363210.
    View in: PubMed
  10. van der Valk FM, Kuijk C, Verweij SL, Stiekema LCA, Kaiser Y, Zeerleder S, Nahrendorf M, Voermans C, Stroes ESG. Increased haematopoietic activity in patients with atherosclerosis. Eur Heart J. 2017 Feb 07; 38(6):425-432. PMID: 27357356.
    View in: PubMed
  11. Je KH, Ryu WS, Lee SK, Kim EJ, Kim JY, Jang HJ, Park JE, Nahrendorf M, Schellingerhout D, Kim DE. Green-channel autofluorescence imaging: A novel and sensitive technique to delineate infarcts. J Neurosci Methods. 2017 Mar 01; 279:22-32. PMID: 28104485.
    View in: PubMed
  12. Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M. Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun. 2017 Jan 16; 8:14064. PMID: 28091604.
    View in: PubMed
  13. Frodermann V, Nahrendorf M. Neutrophil-macrophage cross-talk in acute myocardial infarction. Eur Heart J. 2017 Jan 14; 38(3):198-200. PMID: 28158564.
    View in: PubMed
  14. Tawakol A, Ishai A, Takx RA, Figueroa AL, Ali A, Kaiser Y, Truong QA, Solomon CJ, Calcagno C, Mani V, Tang CY, Mulder WJ, Murrough JW, Hoffmann U, Nahrendorf M, Shin LM, Fayad ZA, Pitman RK. Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study. Lancet. 2017 Feb 25; 389(10071):834-845. PMID: 28088338.
    View in: PubMed
  15. Tang J, Baxter S, Menon A, Alaarg A, Sanchez-Gaytan BL, Fay F, Zhao Y, Ouimet M, Braza MS, Longo VA, Abdel-Atti D, Duivenvoorden R, Calcagno C, Storm G, Tsimikas S, Moore KJ, Swirski FK, Nahrendorf M, Fisher EA, Pérez-Medina C, Fayad ZA, Reiner T, Mulder WJ. Immune cell screening of a nanoparticle library improves atherosclerosis therapy. Proc Natl Acad Sci U S A. 2016 Nov 01; 113(44):E6731-E6740. PMID: 27791119.
    View in: PubMed
  16. Kim J, Park JE, Nahrendorf M, Kim DE. Direct Thrombus Imaging in Stroke. J Stroke. 2016 Sep; 18(3):286-296. PMID: 27733029.
    View in: PubMed
  17. Swirski FK, Nahrendorf M. Bone Marrow Takes Center Stage in Cardiovascular Disease. Circ Res. 2016 Sep 02; 119(6):701-3. PMID: 27587406; PMCID: PMC5012290 [Available on 09/02/17].
  18. Swirski FK, Nahrendorf M, Libby P. Mechanisms of Myeloid Cell Modulation of Atherosclerosis. Microbiol Spectr. 2016 Aug; 4(4). PMID: 27726819.
    View in: PubMed
  19. Dutta P, Hoyer FF, Sun Y, Iwamoto Y, Tricot B, Weissleder R, Magnani JL, Swirski FK, Nahrendorf M. E-Selectin Inhibition Mitigates Splenic HSC Activation and Myelopoiesis in Hypercholesterolemic Mice With Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2016 Sep; 36(9):1802-8. PMID: 27470513; PMCID: PMC5001901 [Available on 09/01/17].
  20. Libby P, Nahrendorf M, Swirski FK. Reply: The Networks Between the Sympathetic Nervous System and Immune System in Atherosclerosis. J Am Coll Cardiol. 2016 Jul 26; 68(4):432. PMID: 27443446.
    View in: PubMed
  21. Pinciroli R, Mietto C, Piriyapatsom A, Chenelle CT, Thomas JG, Pirrone M, Bry L, Wojtkiewicz GR, Nahrendorf MP, Kacmarek RM, Berra L. Endotracheal Tubes Cleaned With a Novel Mechanism for Secretion Removal: A Randomized Controlled Clinical Study. Respir Care. 2016 Nov; 61(11):1431-1439. PMID: 27460104.
    View in: PubMed
  22. Nahrendorf M, Swirski FK. Abandoning M1/M2 for a Network Model of Macrophage Function. Circ Res. 2016 Jul 22; 119(3):414-7. PMID: 27458196; PMCID: PMC4965179 [Available on 07/22/17].
  23. Sager HB, Hulsmans M, Lavine KJ, Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure. Circ Res. 2016 Sep 16; 119(7):853-64. PMID: 27444755.
    View in: PubMed
  24. Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK. On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat Med. 2016 Aug; 22(8):945-51. PMID: 27428900; PMCID: PMC4957133 [Available on 01/18/17].
  25. Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M. RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction. Sci Transl Med. 2016 Jun 08; 8(342):342ra80. PMID: 27280687.
    View in: PubMed
  26. Sager HB, Nahrendorf M. Inflammation: a trigger for acute coronary syndrome. Q J Nucl Med Mol Imaging. 2016 Sep; 60(3):185-93. PMID: 27273431.
    View in: PubMed
  27. Ryu WS, Schellingerhout D, Jeong SW, Nahrendorf M, Kim DE. Association between Serum Lipid Profiles and Early Neurological Deterioration in Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2016 Aug; 25(8):2024-30. PMID: 27256172.
    View in: PubMed
  28. Rischpler C, Dirschinger RJ, Nekolla SG, Kossmann H, Nicolosi S, Hanus F, van Marwick S, Kunze KP, Meinicke A, Götze K, Kastrati A, Langwieser N, Ibrahim T, Nahrendorf M, Schwaiger M, Laugwitz KL. Prospective Evaluation of 18F-Fluorodeoxyglucose Uptake in Postischemic Myocardium by Simultaneous Positron Emission Tomography/Magnetic Resonance Imaging as a Prognostic Marker of Functional Outcome. Circ Cardiovasc Imaging. 2016 Apr; 9(4):e004316. PMID: 27056601; PMCID: PMC4826716 [Available on 04/01/17].
  29. Frodermann V, Nahrendorf M. Neutrophil-macrophage cross-talk in acute myocardial infarction. Eur Heart J. 2016 Mar 16. PMID: 26984866.
    View in: PubMed
  30. Libby P, Nahrendorf M, Swirski FK. Leukocytes Link Local and Systemic Inflammation in Ischemic Cardiovascular Disease: An Expanded "Cardiovascular Continuum". J Am Coll Cardiol. 2016 Mar 08; 67(9):1091-103. PMID: 26940931; PMCID: PMC4779182 [Available on 03/08/17].
  31. Davis RW, Brannen AD, Hossain MJ, Monsma S, Bock PE, Nahrendorf M, Mead D, Lodes M, Liles MR, Panizzi P. Complete genome of Staphylococcus aureus Tager 104 provides evidence of its relation to modern systemic hospital-acquired strains. BMC Genomics. 2016 Mar 03; 17:179. PMID: 26940863; PMCID: PMC4778325.
  32. Calcagno C, Mulder WJ, Nahrendorf M, Fayad ZA. Systems Biology and Noninvasive Imaging of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2016 Feb; 36(2):e1-8. PMID: 26819466; PMCID: PMC4861402 [Available on 02/01/17].
  33. Valero-Muñoz M, Li S, Wilson RM, Hulsmans M, Aprahamian T, Fuster JJ, Nahrendorf M, Scherer PE, Sam F. Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue. Circ Heart Fail. 2016 Jan; 9(1):e002724. PMID: 26721917; PMCID: PMC4698901 [Available on 01/01/17].
  34. Swirski FK, Robbins CS, Nahrendorf M. Development and Function of Arterial and Cardiac Macrophages. Trends Immunol. 2016 Jan; 37(1):32-40. PMID: 26748179; PMCID: PMC4706986 [Available on 01/01/17].
  35. Nahrendorf M, Swirski FK. PET Imaging of Leukocytes in Patients With Acute Myocardial Infarction. JACC Cardiovasc Imaging. 2015 Dec; 8(12):1427-9. PMID: 26699111.
    View in: PubMed
  36. Davis RW, Eggleston H, Johnson F, Nahrendorf M, Bock PE, Peterson T, Panizzi P. In Vivo Tracking of Streptococcal Infections of Subcutaneous Origin in a Murine Model. Mol Imaging Biol. 2015 Dec; 17(6):793-801. PMID: 25921659; PMCID: PMC4807872 [Available on 12/01/16].
  37. Weissleder R, Nahrendorf M. Advancing biomedical imaging. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14424-8. PMID: 26598657; PMCID: PMC4664297.
  38. Hulsmans M, Sam F, Nahrendorf M. Monocyte and macrophage contributions to cardiac remodeling. J Mol Cell Cardiol. 2016 Apr; 93:149-55. PMID: 26593722; PMCID: PMC4846552 [Available on 04/01/17].
  39. Signore S, Sorrentino A, Borghetti G, Cannata A, Meo M, Zhou Y, Kannappan R, Pasqualini F, O'Malley H, Sundman M, Tsigkas N, Zhang E, Arranto C, Mangiaracina C, Isobe K, Sena BF, Kim J, Goichberg P, Nahrendorf M, Isom LL, Leri A, Anversa P, Rota M. Late Na(+) current and protracted electrical recovery are critical determinants of the aging myopathy. Nat Commun. 2015 Nov 06; 6:8803. PMID: 26541940; PMCID: PMC4638135.
  40. Joseph P, Ishai A, MacNabb M, Abdelbaky A, Lavender ZR, Ruskin J, Nahrendorf M, Tawakol A. Atrial fibrillation is associated with hematopoietic tissue activation and arterial inflammation. Int J Cardiovasc Imaging. 2016 Jan; 32(1):113-9. PMID: 26411879; PMCID: PMC4730873 [Available on 01/01/17].
  41. Ye YX, Calcagno C, Binderup T, Courties G, Keliher EJ, Wojtkiewicz GR, Iwamoto Y, Tang J, Pérez-Medina C, Mani V, Ishino S, Johnbeck CB, Knigge U, Fayad ZA, Libby P, Weissleder R, Tawakol A, Dubey S, Belanger AP, Di Carli MF, Swirski FK, Kjaer A, Mulder WJ, Nahrendorf M. Imaging Macrophage and Hematopoietic Progenitor Proliferation in Atherosclerosis. Circ Res. 2015 Oct 23; 117(10):835-45. PMID: 26394773; PMCID: PMC4619168 [Available on 10/23/16].
  42. Sager HB, Heidt T, Hulsmans M, Dutta P, Courties G, Sebas M, Wojtkiewicz GR, Tricot B, Iwamoto Y, Sun Y, Weissleder R, Libby P, Swirski FK, Nahrendorf M. Targeting Interleukin-1ß Reduces Leukocyte Production After Acute Myocardial Infarction. Circulation. 2015 Nov 17; 132(20):1880-90. PMID: 26358260; PMCID: PMC4651795 [Available on 11/17/16].
  43. Nahrendorf M, Swirski FK. Innate immune cells in ischaemic heart disease: does myocardial infarction beget myocardial infarction? Eur Heart J. 2016 Mar 14; 37(11):868-72. PMID: 26351395; PMCID: PMC4789592 [Available on 03/14/17].
  44. Gonçalves I, den Ruijter H, Nahrendorf M, Pasterkamp G. Detecting the vulnerable plaque in patients. J Intern Med. 2015 Nov; 278(5):520-30. PMID: 26306911.
    View in: PubMed
  45. Nahrendorf M, Dutta P. Targeting splenic hematopoietic stem cells in cardiovascular disease. Oncotarget. 2015 Aug 21; 6(24):19918-9. PMID: 26343366; PMCID: PMC4652955.
  46. He S, Chousterman BG, Fenn A, Anzai A, Nairz M, Brandt M, Hilgendorf I, Sun Y, Ye YX, Iwamoto Y, Tricot B, Weissleder R, Macphee C, Libby P, Nahrendorf M, Swirski FK. Lp-PLA2 Antagonizes Left Ventricular Healing After Myocardial Infarction by Impairing the Appearance of Reparative Macrophages. Circ Heart Fail. 2015 Sep; 8(5):980-7. PMID: 26232205; PMCID: PMC4568849.
  47. Nahrendorf M, Swirski FK. Immunology. Neutrophil-macrophage communication in inflammation and atherosclerosis. Science. 2015 Jul 17; 349(6245):237-8. PMID: 26185231.
    View in: PubMed
  48. Kim JY, Ryu JH, Schellingerhout D, Sun IC, Lee SK, Jeon S, Kim J, Kwon IC, Nahrendorf M, Ahn CH, Kim K, Kim DE. Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles. Theranostics. 2015; 5(10):1098-114. PMID: 26199648; PMCID: PMC4508499.
  49. Dutta P, Sager HB, Stengel KR, Naxerova K, Courties G, Saez B, Silberstein L, Heidt T, Sebas M, Sun Y, Wojtkiewicz G, Feruglio PF, King K, Baker JN, van der Laan AM, Borodovsky A, Fitzgerald K, Hulsmans M, Hoyer F, Iwamoto Y, Vinegoni C, Brown D, Di Carli M, Libby P, Hiebert SW, Scadden DT, Swirski FK, Weissleder R, Nahrendorf M. Myocardial Infarction Activates CCR2(+) Hematopoietic Stem and Progenitor Cells. Cell Stem Cell. 2015 May 07; 16(5):477-87. PMID: 25957903; PMCID: PMC4426344 [Available on 05/07/16].
  50. Nahrendorf M, Frantz S, Swirski FK, Mulder WJ, Randolph G, Ertl G, Ntziachristos V, Piek JJ, Stroes ES, Schwaiger M, Mann DL, Fayad ZA. Imaging systemic inflammatory networks in ischemic heart disease. J Am Coll Cardiol. 2015 Apr 21; 65(15):1583-91. PMID: 25881940; PMCID: PMC4401833.
  51. Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Cell Metab. 2015 Apr 07; 21(4):609-21. PMID: 25863250; PMCID: PMC4663978.
  52. Tang J, Lobatto ME, Hassing L, van der Staay S, van Rijs SM, Calcagno C, Braza MS, Baxter S, Fay F, Sanchez-Gaytan BL, Duivenvoorden R, Sager H, Astudillo YM, Leong W, Ramachandran S, Storm G, Pérez-Medina C, Reiner T, Cormode DP, Strijkers GJ, Stroes ES, Swirski FK, Nahrendorf M, Fisher EA, Fayad ZA, Mulder WJ. Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation. Sci Adv. 2015 Apr; 1(3). PMID: 26295063.
    View in: PubMed
  53. Dutta P, Hoyer FF, Grigoryeva LS, Sager HB, Leuschner F, Courties G, Borodovsky A, Novobrantseva T, Ruda VM, Fitzgerald K, Iwamoto Y, Wojtkiewicz G, Sun Y, Da Silva N, Libby P, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. J Exp Med. 2015 Apr 06; 212(4):497-512. PMID: 25800955; PMCID: PMC4387283.
  54. Dutta P, Nahrendorf M. Monocytes in myocardial infarction. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1066-70. PMID: 25792449; PMCID: PMC4409536 [Available on 05/01/16].
  55. Weber GF, Chousterman BG, He S, Fenn AM, Nairz M, Anzai A, Brenner T, Uhle F, Iwamoto Y, Robbins CS, Noiret L, Maier SL, Zönnchen T, Rahbari NN, Schölch S, Klotzsche-von Ameln A, Chavakis T, Weitz J, Hofer S, Weigand MA, Nahrendorf M, Weissleder R, Swirski FK. Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis. Science. 2015 Mar 13; 347(6227):1260-5. PMID: 25766237; PMCID: PMC4376966.
  56. Nahrendorf M, Swirski FK. Lifestyle effects on hematopoiesis and atherosclerosis. Circ Res. 2015 Feb 27; 116(5):884-94. PMID: 25722442; PMCID: PMC4347940.
  57. Emami H, Singh P, MacNabb M, Vucic E, Lavender Z, Rudd JH, Fayad ZA, Lehrer-Graiwer J, Korsgren M, Figueroa AL, Fredrickson J, Rubin B, Hoffmann U, Truong QA, Min JK, Baruch A, Nasir K, Nahrendorf M, Tawakol A. Splenic metabolic activity predicts risk of future cardiovascular events: demonstration of a cardiosplenic axis in humans. JACC Cardiovasc Imaging. 2015 Feb; 8(2):121-30. PMID: 25577441.
    View in: PubMed
  58. Mietto C, Pinciroli R, Piriyapatsom A, Thomas JG, Bry L, Delaney ML, Du Bois A, Truelove J, Ackman JB, Wojtkiewicz GR, Nahrendorf M, Kacmarek RM, Berra L. Tracheal tube obstruction in mechanically ventilated patients assessed by high-resolution computed tomography. Anesthesiology. 2014 Dec; 121(6):1226-35. PMID: 25254903.
    View in: PubMed
  59. Dutta P, Nahrendorf M. Regulation and consequences of monocytosis. Immunol Rev. 2014 Nov; 262(1):167-78. PMID: 25319334; PMCID: PMC4203415.
  60. Courties G, Herisson F, Sager HB, Heidt T, Ye Y, Wei Y, Sun Y, Severe N, Dutta P, Scharff J, Scadden DT, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M. Ischemic stroke activates hematopoietic bone marrow stem cells. Circ Res. 2015 Jan 30; 116(3):407-17. PMID: 25362208; PMCID: PMC4312511 [Available on 01/30/16].
  61. Swirski FK, Nahrendorf M. Do vascular smooth muscle cells differentiate to macrophages in atherosclerotic lesions? Circ Res. 2014 Sep 12; 115(7):605-6. PMID: 25214571; PMCID: PMC4166538.
  62. Taqueti VR, Nahrendorf M, Di Carli MF. Translational molecular imaging: repurposing an old technique to track cell migration into human atheroma. J Am Coll Cardiol. 2014 Sep 09; 64(10):1030-2. PMID: 25190239.
    View in: PubMed
  63. Nahrendorf M, Swirski FK. Imaging systemic inflammation in patients with acute myocardial infarction. Circ Cardiovasc Imaging. 2014 Sep; 7(5):762-4. PMID: 25227235.
    View in: PubMed
  64. Taqueti VR, Di Carli MF, Jerosch-Herold M, Sukhova GK, Murthy VL, Folco EJ, Kwong RY, Ozaki CK, Belkin M, Nahrendorf M, Weissleder R, Libby P. Increased microvascularization and vessel permeability associate with active inflammation in human atheromata. Circ Cardiovasc Imaging. 2014 Nov; 7(6):920-9. PMID: 25170063; PMCID: PMC4237630.
  65. Heidt T, Sager HB, Courties G, Dutta P, Iwamoto Y, Zaltsman A, von Zur Muhlen C, Bode C, Fricchione GL, Denninger J, Lin CP, Vinegoni C, Libby P, Swirski FK, Weissleder R, Nahrendorf M. Chronic variable stress activates hematopoietic stem cells. Nat Med. 2014 Jul; 20(7):754-8. PMID: 24952646; PMCID: PMC4087061.
  66. Nahrendorf M, Swirski FK. Regulating repair: regulatory T cells in myocardial infarction. Circ Res. 2014 Jun 20; 115(1):7-9. PMID: 24951758; PMCID: PMC4094354.
  67. Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M. Silencing of CCR2 in myocarditis. Eur Heart J. 2015 Jun 14; 36(23):1478-88. PMID: 24950695; PMCID: PMC4465633 [Available on 06/14/16].
  68. Mulder WJ, Jaffer FA, Fayad ZA, Nahrendorf M. Imaging and nanomedicine in inflammatory atherosclerosis. Sci Transl Med. 2014 Jun 04; 6(239):239sr1. PMID: 24898749; PMCID: PMC4110972.
  69. Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK. Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med. 2014 Jun 02; 211(6):1243-56. PMID: 24821911; PMCID: PMC4042649.
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  140. Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009 Jul 31; 325(5940):612-6. PMID: 19644120; PMCID: PMC2803111.
  141. Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R. Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors. Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1444-51. PMID: 19608968; PMCID: PMC2746251.
  142. Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation. 2008 Mar 04; 117(9):1153-60. PMID: 18268141; PMCID: PMC2673051.
  143. Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik DE, Aikawa E, Libby P, Swirski FK, Weissleder R. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008 Jan 22; 117(3):379-87. PMID: 18158358; PMCID: PMC2663426.
  144. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007 Nov 26; 204(12):3037-47. PMID: 18025128; PMCID: PMC2118517.
  145. Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande AN, Aikawa E, Figueiredo JL, Pittet MJ, Weissleder R. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res. 2007 Apr 27; 100(8):1218-25. PMID: 17379832.
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  146. Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R. Noninvasive vascular cell adhesion molecule-1 imaging identifies inflammatory activation of cells in atherosclerosis. Circulation. 2006 Oct 03; 114(14):1504-11. PMID: 17000904.
    View in: PubMed
  147. Nahrendorf M, Hu K, Frantz S, Jaffer FA, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlöhner S, Novikov M, Dickneite G, Reed GL, Jakob P, Rosenzweig A, Bauer WR, Weissleder R, Ertl G. Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction. Circulation. 2006 Mar 07; 113(9):1196-202. PMID: 16505171; PMCID: PMC4066325.
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