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Rooma Desai, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Masiulis S, Desai R, Uchanski T, Martin IS, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR. Author Correction: GABAA receptor signalling mechanisms revealed by structural pharmacology. Nature. 2019 Feb; 566(7744):E8. PMID: 30733619.
    Citations:    
  2. Masiulis S, Desai R, Uchanski T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, Pardon E, Kotecha A, Steyaert J, Miller KW, Aricescu AR. GABAA receptor signalling mechanisms revealed by structural pharmacology. Nature. 2019 01; 565(7740):454-459. PMID: 30602790.
    Citations:    Fields:    
  3. Laverty D, Desai R, Uchanski T, Masiulis S, Stec WJ, Malinauskas T, Zivanov J, Pardon E, Steyaert J, Miller KW, Aricescu AR. Cryo-EM structure of the human a1ß3?2 GABAA receptor in a lipid bilayer. Nature. 2019 01; 565(7740):516-520. PMID: 30602789.
    Citations:    Fields:    
  4. Zhou X, Desai R, Zhang Y, Stec WJ, Miller KW, Jounaidi Y. High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing a4ß3d subunits. PLoS One. 2018; 13(1):e0191583. PMID: 29352320.
    Citations:    Fields:    Translation:HumansCells
  5. Savechenkov PY, Chiara DC, Desai R, Stern AT, Zhou X, Ziemba AM, Szabo AL, Zhang Y, Cohen JB, Forman SA, Miller KW, Bruzik KS. Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands. Eur J Med Chem. 2017 Aug 18; 136:334-347. PMID: 28505538.
    Citations: 1     Fields:    Translation:HumansCells
  6. Zhang Y, Zhang XF, Fleming MR, Amiri A, El-Hassar L, Surguchev AA, Hyland C, Jenkins DP, Desai R, Brown MR, Gazula VR, Waters MF, Large CH, Horvath TL, Navaratnam D, Vaccarino FM, Forscher P, Kaczmarek LK. Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell. 2016 Apr 07; 165(2):434-448. PMID: 26997484; PMCID: PMC4826296.
    Citations: 7     Fields:    Translation:Cells
  7. Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW. Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the a1 ß3 ?2L GABAA receptor account for their in vivo effects. J Physiol. 2015 Nov 15; 593(22):4943-61. PMID: 26378885; PMCID: PMC4650410.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB. Positive and Negative Allosteric Modulation of an a1ß3?2 ?-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the ?+-ß- Interface. J Biol Chem. 2015 Sep 18; 290(38):23432-46. PMID: 26229099; PMCID: PMC4645599.
    Citations: 8     Fields:    Translation:HumansCells
  9. Dostalova Z, Zhou X, Liu A, Zhang X, Zhang Y, Desai R, Forman SA, Miller KW. Human a1ß3?2L gamma-aminobutyric acid type A receptors: High-level production and purification in a functional state. Protein Sci. 2014 Feb; 23(2):157-66. PMID: 24288268; PMCID: PMC3926741.
    Citations: 8     Fields:    Translation:HumansCells
  10. Stewart DS, Hotta M, Li GD, Desai R, Chiara DC, Olsen RW, Forman SA. Cysteine substitutions define etomidate binding and gating linkages in the a-M1 domain of ?-aminobutyric acid type A (GABAA) receptors. J Biol Chem. 2013 Oct 18; 288(42):30373-86. PMID: 24009076; PMCID: PMC3798502.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. Stewart DS, Hotta M, Desai R, Forman SA. State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor. Mol Pharmacol. 2013 Jun; 83(6):1200-8. PMID: 23525330; PMCID: PMC3657098.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  12. Desai R, Miller KW, Raines DE. The pyrrole etomidate analog carboetomidate potently inhibits human 5-HT3A receptor function: comparisons with etomidate and potential implications for emetogenesis. Anesth Analg. 2013 Mar; 116(3):573-9. PMID: 23400978; PMCID: PMC3582768.
    Citations: 2     Fields:    Translation:HumansCells
  13. Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW. p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. J Med Chem. 2010 Sep 09; 53(17):6432-44. PMID: 20704351; PMCID: PMC3117435.
    Citations: 11     Fields:    Translation:AnimalsCells
  14. Dostalova Z, Liu A, Zhou X, Farmer SL, Krenzel ES, Arevalo E, Desai R, Feinberg-Zadek PL, Davies PA, Yamodo IH, Forman SA, Miller KW. High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors. Protein Sci. 2010 Sep; 19(9):1728-38. PMID: 20662008; PMCID: PMC2975136.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  15. Desai R, Ruesch D, Forman SA. Gamma-amino butyric acid type A receptor mutations at beta2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity. Anesthesiology. 2009 Oct; 111(4):774-84. PMID: 19741491; PMCID: PMC2798018.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  16. Stewart D, Desai R, Cheng Q, Liu A, Forman SA. Tryptophan mutations at azi-etomidate photo-incorporation sites on alpha1 or beta2 subunits enhance GABAA receptor gating and reduce etomidate modulation. Mol Pharmacol. 2008 Dec; 74(6):1687-95. PMID: 18805938; PMCID: PMC2596762.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  17. Desai R, Kronengold J, Mei J, Forman SA, Kaczmarek LK. Protein kinase C modulates inactivation of Kv3.3 channels. J Biol Chem. 2008 Aug 08; 283(32):22283-94. PMID: 18539595; PMCID: PMC2494927.
    Citations: 20     Fields:    Translation:AnimalsCells
  18. Badou A, Basavappa S, Desai R, Peng YQ, Matza D, Mehal WZ, Kaczmarek LK, Boulpaep EL, Flavell RA. Requirement of voltage-gated calcium channel beta4 subunit for T lymphocyte functions. Science. 2005 Jan 07; 307(5706):117-21. PMID: 15637280.
    Citations: 5     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.