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Quan Lu, Ph.D.

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Overview
My laboratory studies molecular mechanisms underlying complex gene-environment interactions in multigenic human diseases such as asthma and neurodegeneration, focusing in part on the emerging role of extracellular vesicles in disease pathogenesis, prevention, and therapeutics. Research in my laboratory is supported by multiple NIH R01 grants and a Program Project grant as well as gifts from private companies and foundations. Here are some examples of our recent work.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P42ES030990 (LU, QUAN) Feb 21, 2020 - Jan 31, 2025
    NIH
    Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)
    Role: Principal Investigator
  2. R01ES030302 (WRIGHT, ROSALIND J) Jun 1, 2019 - May 31, 2024
    NIH
    Prenatal metal mixtures and neurodevelopment: Role of placental extracellular microRNAs
    Role: Co-Principal Investigator
  3. R01ES029097 (LU, QUAN) Sep 30, 2018 - Aug 31, 2023
    NIH
    SPP1, Oxidative Stress, and Lead Toxicity
    Role: Principal Investigator
  4. R01HL139496 (LU, QUAN) Jan 1, 2018 - Nov 30, 2021
    NIH
    MicroRNA-10a in Airway Smooth Muscle and Asthma
    Role: Principal Investigator
  5. R01AI125152 (LU, QUAN) May 19, 2016 - Apr 30, 2020
    NIH
    Plasma Gelsolin as Immunotherapeutic for Antibiotic-Resistant Pneumonia
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tiwari A, Li J, Kho AT, Sun M, Lu Q, Weiss ST, Tantisira KG, McGeachie MJ. COPD-associated miR-145-5p is downregulated in early-decline FEV1 trajectories in childhood asthma. J Allergy Clin Immunol. 2020 Dec 29. PMID: 33385444.
    Citations: 1     Fields:    
  2. Li J, Panganiban R, Kho AT, McGeachie MJ, Farnam L, Chase RP, Weiss ST, Lu Q, Tantisira KG. Circulating MicroRNAs and Treatment Response in Childhood Asthma. Am J Respir Crit Care Med. 2020 07 01; 202(1):65-72. PMID: 32272022.
    Citations: 3     Fields:    Translation:Humans
  3. Park HR, Sun R, Panganiban RA, Christiani DC, Lu Q. MicroRNA-124 Reduces Arsenic-induced Endoplasmic Reticulum Stress and Neurotoxicity and is Linked with Neurodevelopment in Children. Sci Rep. 2020 04 03; 10(1):5934. PMID: 32246005.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  4. McGeachie MJ, Sordillo JE, Dahlin A, Wang AL, Lutz SM, Tantisira KG, Panganiban R, Lu Q, Sajuthi S, Urbanek C, Kelly R, Saef B, Eng C, Oh SS, Kho AT, Croteau-Chonka DC, Weiss ST, Raby BA, Mak ACY, Rodriguez-Santana JR, Burchard EG, Seibold MA, Wu AC. Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy. Respir Res. 2020 Jan 28; 21(1):31. PMID: 31992292.
    Citations:    Fields:    Translation:Humans
  5. Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q. Hyperinsulinemia promotes heterologous desensitization of ß2 adrenergic receptor in airway smooth muscle in obesity. FASEB J. 2020 03; 34(3):3996-4008. PMID: 31960515.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Yang Z, Bedugnis A, Levinson S, DiNubile M, Stossel T, Lu Q, Kobzik L. Delayed administration of recombinant plasma gelsolin improves survival in a murine model of severe influenza. F1000Res. 2019; 8:1860. PMID: 31824672.
    Citations: 2     Fields:    
  7. Zhu Z, Guo Y, Shi H, Liu CL, Panganiban RA, Chung W, O'Connor LJ, Himes BE, Gazal S, Hasegawa K, Camargo CA, Qi L, Moffatt MF, Hu FB, Lu Q, Cookson WOC, Liang L. Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank. J Allergy Clin Immunol. 2020 02; 145(2):537-549. PMID: 31669095.
    Citations: 13     Fields:    Translation:HumansAnimals
  8. Yang Z, Bedugnis A, Levinson S, Dinubile M, Stossel T, Lu Q, Kobzik L. Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia. J Infect Dis. 2019 09 26; 220(9):1498-1502. PMID: 31287867.
    Citations: 2     Fields:    Translation:Animals
  9. Panganiban RA, Park HR, Sun M, Shumyatcher M, Himes BE, Lu Q. Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13384-13393. PMID: 31213543.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  10. Park HR, O'Sullivan M, Vallarino J, Shumyatcher M, Himes BE, Park JA, Christiani DC, Allen J, Lu Q. Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes. Sci Rep. 2019 02 01; 9(1):1400. PMID: 30710127.
    Citations: 24     Fields:    Translation:HumansCellsPHPublic Health
  11. Dahlin A, Sordillo JE, Ziniti J, Iribarren C, Lu M, Weiss ST, Tantisira KG, Lu Q, Kan M, Himes BE, Jorgenson E, Wu AC. Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults. J Allergy Clin Immunol. 2019 04; 143(4):1633-1635. PMID: 30578877.
    Citations: 7     Fields:    Translation:Humans
  12. Zhu Z, Lee PH, Chaffin MD, Chung W, Loh PR, Lu Q, Christiani DC, Liang L. Author Correction: A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat Genet. 2018 12; 50(12):1753. PMID: 30390058.
    Citations:    Fields:    
  13. Sun R, Wang Z, Claus Henn B, Su L, Lu Q, Lin X, Wright RO, Bellinger DC, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Identification of novel loci associated with infant cognitive ability. Mol Psychiatry. 2020 11; 25(11):3010-3019. PMID: 30120420.
    Citations: 2     Fields:    Translation:Humans
  14. Zhu Z, Lee PH, Chaffin MD, Chung W, Loh PR, Lu Q, Christiani DC, Liang L. A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat Genet. 2018 06; 50(6):857-864. PMID: 29785011.
    Citations: 37     Fields:    Translation:Humans
  15. Wang Q, Yu J, Kadungure T, Beyene J, Zhang H, Lu Q. ARMMs as a versatile platform for intracellular delivery of macromolecules. Nat Commun. 2018 03 06; 9(1):960. PMID: 29511190.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  16. McGeachie MJ, Clemmer GL, Hayete B, Xing H, Runge K, Wu AC, Jiang X, Lu Q, Church B, Khalil I, Tantisira K, Weiss S. Systems biology and in vitro validation identifies family with sequence similarity 129 member A (FAM129A) as an asthma steroid response modulator. J Allergy Clin Immunol. 2018 11; 142(5):1479-1488.e12. PMID: 29410046.
    Citations: 4     Fields:    Translation:HumansCells
  17. Panganiban RA, Sun M, Dahlin A, Park HR, Kan M, Himes BE, Mitchel JA, Iribarren C, Jorgenson E, Randell SH, Israel E, Tantisira K, Shore S, Park JA, Weiss ST, Wu AC, Lu Q. A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis. J Allergy Clin Immunol. 2018 11; 142(5):1469-1478.e2. PMID: 29330013.
    Citations: 19     Fields:    Translation:HumansCells
  18. Nwanaji-Enwerem JC, Colicino E, Dai L, Di Q, Just AC, Hou L, Vokonas P, De Vivo I, Lemos B, Lu Q, Weisskopf MG, Baccarelli AA, Schwartz JD. miRNA processing gene polymorphisms, blood DNA methylation age and long-term ambient PM2.5 exposure in elderly men. Epigenomics. 2017 12; 9(12):1529-1542. PMID: 29106301.
    Citations: 5     Fields:    Translation:HumansCells
  19. Zhu Z, Liang L, Zhang R, Wei Y, Su L, Tejera P, Guo Y, Wang Z, Lu Q, Baccarelli AA, Zhu X, Bajwa EK, Taylor Thompson B, Shi GP, Christiani DC. Whole blood microRNA markers are associated with acute respiratory distress syndrome. Intensive Care Med Exp. 2017 Aug 30; 5(1):38. PMID: 28856588.
    Citations: 12     
  20. Jiang X, Dahlin A, Weiss ST, Tantisira K, Lu Q. A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor. Sci Rep. 2017 08 07; 7(1):7405. PMID: 28785063.
    Citations: 4     Fields:    Translation:HumansCells
  21. Wang Z, Claus Henn B, Wang C, Wei Y, Su L, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright R, Bellinger D, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health. 2017 07 28; 16(1):81. PMID: 28754176.
    Citations: 3     Fields:    Translation:HumansCells
  22. Davis JS, Sun M, Kho AT, Moore KG, Sylvia JM, Weiss ST, Lu Q, Tantisira KG. Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort. PLoS One. 2017; 12(7):e0180329. PMID: 28749975.
    Citations: 6     Fields:    Translation:HumansCells
  23. McGeachie MJ, Davis JS, Kho AT, Dahlin A, Sordillo JE, Sun M, Lu Q, Weiss ST, Tantisira KG. Asthma remission: Predicting future airways responsiveness using an miRNA network. J Allergy Clin Immunol. 2017 08; 140(2):598-600.e8. PMID: 28238746.
    Citations: 8     Fields:    Translation:Humans
  24. McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST. Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med. 2016 12 15; 194(12):1465-1474. PMID: 27367781.
    Citations: 8     Fields:    Translation:Humans
  25. Wagner PJ, Park HR, Wang Z, Kirchner R, Wei Y, Su L, Stanfield K, Guilarte TR, Wright RO, Christiani DC, Lu Q. In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children. Environ Health Perspect. 2017 04; 125(4):721-729. PMID: 27562236.
    Citations: 9     Fields:    Translation:HumansCells
  26. Zhu Z, Zhang R, Liang L, Su L, Lu Q, Baccarelli AA, Bajwa EK, Thompson BT, Christiani DC. Whole blood microRNAs as a prognostic classifier for acute respiratory distress syndrome 28-day mortality. Intensive Care Med. 2016 Nov; 42(11):1824-1825. PMID: 27506755.
    Citations: 2     Fields:    Translation:Humans
  27. Dong X, Xu M, Ren Z, Gu J, Lu M, Lu Q, Zhong N. Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma. Int J Mol Med. 2016 Aug; 38(2):446-56. PMID: 27277384.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  28. Sun M, Lu Q. MicroRNA regulation of airway smooth muscle function. Biol Chem. 2016 06 01; 397(6):507-11. PMID: 26812790.
    Citations: 1     Fields:    Translation:HumansAnimals
  29. Rodosthenous RS, Coull BA, Lu Q, Vokonas PS, Schwartz JD, Baccarelli AA. Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals. Part Fibre Toxicol. 2016 Mar 08; 13:13. PMID: 26956024.
    Citations: 26     Fields:    Translation:HumansCellsPHPublic Health
  30. Himes BE, Jiang X, Wagner P, Hu R, Wang Q, Klanderman B, Whitaker RM, Duan Q, Lasky-Su J, Nikolos C, Jester W, Johnson M, Panettieri RA, Tantisira KG, Weiss ST, Lu Q. RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. PLoS One. 2014; 9(6):e99625. PMID: 24926665.
    Citations: 57     Fields:    Translation:HumansCells
  31. Hu R, Pan W, Fedulov AV, Jester W, Jones MR, Weiss ST, Panettieri RA, Tantisira K, Lu Q. MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. FASEB J. 2014 May; 28(5):2347-57. PMID: 24522205.
    Citations: 28     Fields:    Translation:HumansCells
  32. Pan WC, Seow WJ, Kile ML, Hoffman EB, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lu Q, Christiani DC. Association of low to moderate levels of arsenic exposure with risk of type 2 diabetes in Bangladesh. Am J Epidemiol. 2013 Nov 15; 178(10):1563-70. PMID: 24049161.
    Citations: 31     Fields:    Translation:HumansPHPublic Health
  33. Pan WC, Kile ML, Seow WJ, Lin X, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lu Q, Christiani DC. Genetic susceptible locus in NOTCH2 interacts with arsenic in drinking water on risk of type 2 diabetes. PLoS One. 2013; 8(8):e70792. PMID: 23967108.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  34. Himes BE, Jiang X, Hu R, Wu AC, Lasky-Su JA, Klanderman BJ, Ziniti J, Senter-Sylvia J, Lima JJ, Irvin CG, Peters SP, Meyers DA, Bleecker ER, Kubo M, Tamari M, Nakamura Y, Szefler SJ, Lemanske RF, Zeiger RS, Strunk RC, Martinez FD, Hanrahan JP, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Panettieri RA, Markezich A, Israel E, Carey VJ, Tantisira KG, Litonjua AA, Lu Q, Weiss ST. Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet. 2012 Jul; 8(7):e1002824. PMID: 22792082.
    Citations: 41     Fields:    Translation:HumansCells
  35. Nabhan JF, Hu R, Oh RS, Cohen SN, Lu Q. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4146-51. PMID: 22315426.
    Citations: 182     Fields:    Translation:HumansCells
  36. Jiang X, Pan H, Nabhan JF, Krishnan R, Koziol-White C, Panettieri RA, Lu Q. A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in ß2-adrenergic receptor internalization and down-regulation. FASEB J. 2012 May; 26(5):1995-2007. PMID: 22278941.
    Citations: 5     Fields:    Translation:HumansCells
  37. Oh RS, Pan WC, Yalcin A, Zhang H, Guilarte TR, Hotamisligil GS, Christiani DC, Lu Q. Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. J Biol Chem. 2012 Feb 17; 287(8):6025-34. PMID: 22215663.
    Citations: 15     Fields:    Translation:HumansCells
  38. Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet. 2012 Mar 15; 21(6):1325-35. PMID: 22140090.
    Citations: 70     Fields:    Translation:HumansCells
  39. Nabhan JF, Pan H, Lu Q. Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor. . 2010 Aug; 11(8):605-11. PMID: 20559325.
    Citations: 89     Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.