Harvard Catalyst Profiles

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Quan Lu, Ph.D.

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Overview
overview
My laboratory studies molecular mechanisms underlying complex gene-environment interactions in multigenic human diseases such as asthma and neurodegeneration, focusing in part on the emerging role of extracellular vesicles in disease pathogenesis, prevention, and therapeutics. Research in my laboratory is supported by multiple NIH R01 grants and a Program Project grant as well as gifts from private companies and foundations. Here are some examples of our recent work.
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. P42ES030990 (LU, QUAN) Feb 21, 2020 - Jan 31, 2025
    NIH
    Metals and Metal Mixtures: Cognitive Aging, Remediation and Exposure Sources (MEMCARE)
    Role: Principal Investigator
  2. R01ES030302 (WRIGHT, ROSALIND J) Jun 1, 2019 - May 31, 2024
    NIH
    Prenatal metal mixtures and neurodevelopment: Role of placental extracellular microRNAs
    Role: Co-Principal Investigator
  3. R01ES029097 (LU, QUAN) Sep 30, 2018 - Aug 31, 2023
    NIH
    SPP1, Oxidative Stress, and Lead Toxicity
    Role: Principal Investigator
  4. R01HL139496 (LU, QUAN) Jan 1, 2018 - Nov 30, 2021
    NIH
    MicroRNA-10a in Airway Smooth Muscle and Asthma
    Role: Principal Investigator
  5. R01AI125152 (LU, QUAN) May 19, 2016 - Apr 30, 2020
    NIH
    Plasma Gelsolin as Immunotherapeutic for Antibiotic-Resistant Pneumonia
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q. Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles. Sci Adv. 2023 01 27; 9(4):eade2708. PMID: 36706192; PMCID: PMC9882979.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Panganiban RAM, Yang Z, Sun M, Park CY, Kasahara DI, Schaible N, Krishnan R, Kho AT, Israel E, Hershenson MB, Weiss ST, Himes BE, Fredberg JJ, Tantisira KG, Shore SA, Lu Q. Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness. Nat Commun. 2023 01 04; 14(1):47. PMID: 36599824; PMCID: PMC9813361.
    Citations:    Fields:    Translation:Animals
  3. Liu E, Smyth RL, Li Q, Qaseem A, Florez ID, Mathew JL, Amer YS, Estill J, Lu Q, Fu Z, Lu X, Chan ES, Schwarze J, Wong GW, Fukuoka T, Ahn HS, Lee MS, Nurdiati D, Cao B, Tu W, Qian Y, Zhao S, Dong X, Luo X, Chen Z, Li G, Zhang X, Zhao X, Xu H, Xu F, Shi Y, Zhao R, Zhao Y, Lei J, Zheng X, Wang M, Yang S, Feng X, Wu L, He Z, Liu S, Wang Q, Song Y, Luo Z, Zhou Q, Guyatt G, Chen Y, Li Q. Guidelines for the prevention and management of children and adolescents with COVID-19. Eur J Pediatr. 2022 Dec; 181(12):4019-4037. PMID: 36109390; PMCID: PMC9483317.
    Citations:    Fields:    Translation:Humans
  4. Kan M, Sun M, Jiang X, Diwadkar AR, Parikh V, Cao G, Gebski E, Jester W, Lan B, Panettieri RA, Koziol-White C, Lu Q, Himes BE. CEBPD modulates the airway smooth muscle transcriptomic response to glucocorticoids. Respir Res. 2022 Jul 28; 23(1):193. PMID: 35902923; PMCID: PMC9331514.
    Citations: 1     Fields:    Translation:HumansCells
  5. Zhou Q, Li Q, Estill J, Wang Q, Wang Z, Shi Q, Zhang J, Zhang X, Mathew JL, Smyth RL, Nurdiati D, Fu Z, Xu H, Zheng X, Zhao X, Lu Q, Liu H, Xun Y, Li W, Yang S, Feng X, Wang M, Lei J, Luo X, Wu L, Lu X, Lee MS, Zhao S, Chan ES, Qian Y, Tu W, Dong X, Li G, Zhao R, He Z, Zhao S, Liu X, Li Q, Yang K, Luo Z, Liu E, Chen Y. Methodology and experiences of rapid advice guideline development for children with COVID-19: responding to the COVID-19 outbreak quickly and efficiently. BMC Med Res Methodol. 2022 04 03; 22(1):89. PMID: 35369859; PMCID: PMC8977048.
    Citations:    Fields:    Translation:HumansPHPublic Health
  6. Panganiban RA, Lu Q. A Long Noncoding RNA "lnc"ed to Asthma Genetics. Am J Respir Cell Mol Biol. 2022 03; 66(3):243-244. PMID: 35030310; PMCID: PMC8937238.
    Citations:    Fields:    Translation:Humans
  7. Park HR, Vallarino J, O'Sullivan M, Wirth C, Panganiban RA, Webb G, Shumyatcher M, Himes BE, Park JA, Christiani DC, Allen J, Lu Q. Electronic cigarette smoke reduces ribosomal protein gene expression to impair protein synthesis in primary human airway epithelial cells. Sci Rep. 2021 09 01; 11(1):17517. PMID: 34471210; PMCID: PMC8410828.
    Citations: 3     Fields:    Translation:HumansCells
  8. Singh D, Marrocco A, Wohlleben W, Park HR, Diwadkar AR, Himes BE, Lu Q, Christiani DC, Demokritou P. Release of particulate matter from nano-enabled building materials (NEBMs) across their lifecycle: Potential occupational health and safety implications. J Hazard Mater. 2022 01 15; 422:126771. PMID: 34391975; PMCID: PMC8595827.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  9. Wang AL, Panganiban R, Qiu W, Kho AT, Chupp G, Meyers DA, Bleecker ER, Weiss ST, Lu Q, Tantisira KG. Drug Repurposing to Treat Glucocorticoid Resistance in Asthma. J Pers Med. 2021 Mar 03; 11(3). PMID: 33802355; PMCID: PMC7999884.
    Citations: 2     
  10. Tiwari A, Li J, Kho AT, Sun M, Lu Q, Weiss ST, Tantisira KG, McGeachie MJ. COPD-associated miR-145-5p is downregulated in early-decline FEV1 trajectories in childhood asthma. J Allergy Clin Immunol. 2021 06; 147(6):2181-2190. PMID: 33385444; PMCID: PMC8184594.
    Citations: 4     Fields:    Translation:HumansCells
  11. Lu Q, Zhu H, Liu X, Tang C. Icariin sustains the proliferation and differentiation of Aß25-35-treated hippocampal neural stem cells via the BDNF-TrkB-ERK/Akt signaling pathway. Neurol Res. 2020 Nov; 42(11):936-945. PMID: 32727295.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Li J, Panganiban R, Kho AT, McGeachie MJ, Farnam L, Chase RP, Weiss ST, Lu Q, Tantisira KG. Circulating MicroRNAs and Treatment Response in Childhood Asthma. Am J Respir Crit Care Med. 2020 07 01; 202(1):65-72. PMID: 32272022; PMCID: PMC7328325.
    Citations: 14     Fields:    Translation:Humans
  13. Liu E, Smyth RL, Luo Z, Qaseem A, Mathew JL, Lu Q, Fu Z, Zhao X, Zhao S, Estill J, Chan ES, Liu L, Qian Y, Xu H, Wang Q, Fukuoka T, Luo X, Wong GW, Lei J, Nurdiati D, Tu W, Zhang X, Zheng X, Ahn HS, Wang M, Dong X, Wu L, Lee MS, Li G, Yang S, Feng X, Zhao R, Lu X, He Z, Liu S, Li W, Zhou Q, Ren L, Chen Y, Li Q. Erratum to rapid advice guidelines for management of children with COVID-19. Ann Transl Med. 2020 06; 8(12):807. PMID: 32647730; PMCID: PMC7333161.
    Citations:    
  14. Liu E, Smyth RL, Luo Z, Qaseem A, Mathew JL, Lu Q, Fu Z, Zhao X, Zhao S, Estill J, Chan ES, Liu L, Qian Y, Xu H, Wang Q, Fukuoka T, Luo X, Wong GW, Lei J, Nurdiati D, Tu W, Zhang X, Zheng X, Ahn HS, Wang M, Dong X, Wu L, Lee MS, Li G, Yang S, Feng X, Zhao R, Lu X, He Z, Liu S, Li W, Zhou Q, Ren L, Chen Y, Li Q. Rapid advice guidelines for management of children with COVID-19. Ann Transl Med. 2020 May; 8(10):617. PMID: 32566554; PMCID: PMC7290610.
    Citations: 16     
  15. Park HR, Sun R, Panganiban RA, Christiani DC, Lu Q. MicroRNA-124 Reduces Arsenic-induced Endoplasmic Reticulum Stress and Neurotoxicity and is Linked with Neurodevelopment in Children. Sci Rep. 2020 04 03; 10(1):5934. PMID: 32246005.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  16. McGeachie MJ, Sordillo JE, Dahlin A, Wang AL, Lutz SM, Tantisira KG, Panganiban R, Lu Q, Sajuthi S, Urbanek C, Kelly R, Saef B, Eng C, Oh SS, Kho AT, Croteau-Chonka DC, Weiss ST, Raby BA, Mak ACY, Rodriguez-Santana JR, Burchard EG, Seibold MA, Wu AC. Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy. Respir Res. 2020 Jan 28; 21(1):31. PMID: 31992292; PMCID: PMC6988322.
    Citations:    Fields:    Translation:Humans
  17. Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q. Hyperinsulinemia promotes heterologous desensitization of ß2 adrenergic receptor in airway smooth muscle in obesity. FASEB J. 2020 03; 34(3):3996-4008. PMID: 31960515.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  18. Yang Z, Bedugnis A, Levinson S, DiNubile M, Stossel T, Lu Q, Kobzik L. Delayed administration of recombinant plasma gelsolin improves survival in a murine model of severe influenza. F1000Res. 2019; 8:1860. PMID: 31824672; PMCID: PMC6894358.
    Citations: 3     Fields:    Translation:HumansAnimals
  19. Zhu Z, Guo Y, Shi H, Liu CL, Panganiban RA, Chung W, O'Connor LJ, Himes BE, Gazal S, Hasegawa K, Camargo CA, Qi L, Moffatt MF, Hu FB, Lu Q, Cookson WOC, Liang L. Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank. J Allergy Clin Immunol. 2020 02; 145(2):537-549. PMID: 31669095; PMCID: PMC7010560.
    Citations: 65     Fields:    Translation:HumansAnimals
  20. Yang Z, Bedugnis A, Levinson S, Dinubile M, Stossel T, Lu Q, Kobzik L. Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia. J Infect Dis. 2019 09 26; 220(9):1498-1502. PMID: 31287867; PMCID: PMC6761947.
    Citations: 2     Fields:    Translation:Animals
  21. Cardet JC, Jiang X, Lu Q, Gerard N, McIntire K, Boushey HA, Castro M, Chinchilli VM, Codispoti CD, Dyer AM, Holguin F, Kraft M, Lazarus S, Lemanske RF, Lugogo N, Mauger D, Moore WC, Moy J, Ortega VE, Peters SP, Smith LJ, Solway J, Sorkness CA, Sumino K, Wechsler ME, Wenzel S, Israel E. Reply. J Allergy Clin Immunol. 2019 09; 144(3):873-874. PMID: 31300279.
    Citations:    Fields:    
  22. Panganiban RA, Park HR, Sun M, Shumyatcher M, Himes BE, Lu Q. Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis. Proc Natl Acad Sci U S A. 2019 07 02; 116(27):13384-13393. PMID: 31213543; PMCID: PMC6613086.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  23. Cardet JC, Jiang X, Lu Q, Gerard N, McIntire K, Boushey HA, Castro M, Chinchilli VM, Codispoti CD, Dyer AM, Holguin F, Kraft M, Lazarus S, Lemanske RF, Lugogo N, Mauger D, Moore WC, Moy J, Ortega VE, Peters SP, Smith LJ, Solway J, Sorkness CA, Sumino K, Wechsler ME, Wenzel S, Israel E. Loss of bronchoprotection with ICS plus LABA treatment, ß-receptor dynamics, and the effect of alendronate. J Allergy Clin Immunol. 2019 08; 144(2):416-425.e7. PMID: 30872116; PMCID: PMC6950766.
    Citations: 1     Fields:    Translation:Humans
  24. He S, Carman CV, Lee JH, Lan B, Koehler S, Atia L, Park CY, Kim JH, Mitchel JA, Park JA, Butler JP, Lu Q, Fredberg JJ. The tumor suppressor p53 can promote collective cellular migration. PLoS One. 2019; 14(2):e0202065. PMID: 30707705; PMCID: PMC6358060.
    Citations: 4     Fields:    Translation:HumansCells
  25. Park HR, O'Sullivan M, Vallarino J, Shumyatcher M, Himes BE, Park JA, Christiani DC, Allen J, Lu Q. Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes. Sci Rep. 2019 02 01; 9(1):1400. PMID: 30710127; PMCID: PMC6358614.
    Citations: 42     Fields:    Translation:HumansCellsPHPublic Health
  26. Dahlin A, Sordillo JE, Ziniti J, Iribarren C, Lu M, Weiss ST, Tantisira KG, Lu Q, Kan M, Himes BE, Jorgenson E, Wu AC. Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults. J Allergy Clin Immunol. 2019 04; 143(4):1633-1635. PMID: 30578877; PMCID: PMC6451881.
    Citations: 12     Fields:    Translation:Humans
  27. Zhu Z, Lee PH, Chaffin MD, Chung W, Loh PR, Lu Q, Christiani DC, Liang L. Author Correction: A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat Genet. 2018 12; 50(12):1753. PMID: 30390058.
    Citations:    Fields:    
  28. Sun R, Wang Z, Claus Henn B, Su L, Lu Q, Lin X, Wright RO, Bellinger DC, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Identification of novel loci associated with infant cognitive ability. Mol Psychiatry. 2020 11; 25(11):3010-3019. PMID: 30120420; PMCID: PMC6378130.
    Citations: 2     Fields:    Translation:Humans
  29. Zhu Z, Lee PH, Chaffin MD, Chung W, Loh PR, Lu Q, Christiani DC, Liang L. A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases. Nat Genet. 2018 06; 50(6):857-864. PMID: 29785011.
    Citations: 65     Fields:    Translation:Humans
  30. Wang Q, Yu J, Kadungure T, Beyene J, Zhang H, Lu Q. ARMMs as a versatile platform for intracellular delivery of macromolecules. Nat Commun. 2018 03 06; 9(1):960. PMID: 29511190.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  31. McGeachie MJ, Clemmer GL, Hayete B, Xing H, Runge K, Wu AC, Jiang X, Lu Q, Church B, Khalil I, Tantisira K, Weiss S. Systems biology and in vitro validation identifies family with sequence similarity 129 member A (FAM129A) as an asthma steroid response modulator. J Allergy Clin Immunol. 2018 11; 142(5):1479-1488.e12. PMID: 29410046; PMCID: PMC6111005.
    Citations: 4     Fields:    Translation:HumansCells
  32. Lan B, Krishnan R, Park CY, Watanabe RA, Panganiban R, Butler JP, Lu Q, Cole WC, Fredberg JJ. Transient stretch induces cytoskeletal fluidization through the severing action of cofilin. Am J Physiol Lung Cell Mol Physiol. 2018 05 01; 314(5):L799-L807. PMID: 29345194; PMCID: PMC6008132.
    Citations: 10     Fields:    Translation:HumansCells
  33. Panganiban RA, Sun M, Dahlin A, Park HR, Kan M, Himes BE, Mitchel JA, Iribarren C, Jorgenson E, Randell SH, Israel E, Tantisira K, Shore S, Park JA, Weiss ST, Wu AC, Lu Q. A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis. J Allergy Clin Immunol. 2018 11; 142(5):1469-1478.e2. PMID: 29330013; PMCID: PMC6037620.
    Citations: 46     Fields:    Translation:HumansCells
  34. Nwanaji-Enwerem JC, Colicino E, Dai L, Di Q, Just AC, Hou L, Vokonas P, De Vivo I, Lemos B, Lu Q, Weisskopf MG, Baccarelli AA, Schwartz JD. miRNA processing gene polymorphisms, blood DNA methylation age and long-term ambient PM2.5 exposure in elderly men. Epigenomics. 2017 12; 9(12):1529-1542. PMID: 29106301.
    Citations: 7     Fields:    Translation:HumansCells
  35. Wang Q, Lu Q. Plasma membrane-derived extracellular microvesicles mediate non-canonical intercellular NOTCH signaling. Nat Commun. 2017 09 27; 8(1):709. PMID: 28955033; PMCID: PMC5617834.
    Citations: 51     Fields:    Translation:HumansCells
  36. Klager S, Vallarino J, MacNaughton P, Christiani DC, Lu Q, Allen JG. Flavoring Chemicals and Aldehydes in E-Cigarette Emissions. Environ Sci Technol. 2017 Sep 19; 51(18):10806-10813. PMID: 28817267.
    Citations: 38     Fields:    Translation:Cells
  37. Zhu Z, Liang L, Zhang R, Wei Y, Su L, Tejera P, Guo Y, Wang Z, Lu Q, Baccarelli AA, Zhu X, Bajwa EK, Taylor Thompson B, Shi GP, Christiani DC. Whole blood microRNA markers are associated with acute respiratory distress syndrome. Intensive Care Med Exp. 2017 Aug 30; 5(1):38. PMID: 28856588; PMCID: PMC5577350.
    Citations: 20     
  38. Jiang X, Dahlin A, Weiss ST, Tantisira K, Lu Q. A high-throughput chemical screen identifies novel inhibitors and enhancers of anti-inflammatory functions of the glucocorticoid receptor. Sci Rep. 2017 08 07; 7(1):7405. PMID: 28785063.
    Citations: 5     Fields:    Translation:HumansCells
  39. Wang Z, Claus Henn B, Wang C, Wei Y, Su L, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright R, Bellinger D, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health. 2017 07 28; 16(1):81. PMID: 28754176.
    Citations: 5     Fields:    Translation:HumansCells
  40. Davis JS, Sun M, Kho AT, Moore KG, Sylvia JM, Weiss ST, Lu Q, Tantisira KG. Circulating microRNAs and association with methacholine PC20 in the Childhood Asthma Management Program (CAMP) cohort. PLoS One. 2017; 12(7):e0180329. PMID: 28749975.
    Citations: 14     Fields:    Translation:HumansCells
  41. McGeachie MJ, Davis JS, Kho AT, Dahlin A, Sordillo JE, Sun M, Lu Q, Weiss ST, Tantisira KG. Asthma remission: Predicting future airways responsiveness using an miRNA network. J Allergy Clin Immunol. 2017 08; 140(2):598-600.e8. PMID: 28238746; PMCID: PMC5546990.
    Citations: 13     Fields:    Translation:Humans
  42. McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST. Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma. Am J Respir Crit Care Med. 2016 12 15; 194(12):1465-1474. PMID: 27367781; PMCID: PMC5215031.
    Citations: 10     Fields:    Translation:Humans
  43. Wagner PJ, Park HR, Wang Z, Kirchner R, Wei Y, Su L, Stanfield K, Guilarte TR, Wright RO, Christiani DC, Lu Q. In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children. Environ Health Perspect. 2017 04; 125(4):721-729. PMID: 27562236; PMCID: PMC5381979.
    Citations: 12     Fields:    Translation:HumansCells
  44. Zhu Z, Zhang R, Liang L, Su L, Lu Q, Baccarelli AA, Bajwa EK, Thompson BT, Christiani DC. Whole blood microRNAs as a prognostic classifier for acute respiratory distress syndrome 28-day mortality. Intensive Care Med. 2016 Nov; 42(11):1824-1825. PMID: 27506755; PMCID: PMC5586098.
    Citations: 3     Fields:    Translation:Humans
  45. Dong X, Xu M, Ren Z, Gu J, Lu M, Lu Q, Zhong N. Regulation of CBL and ESR1 expression by microRNA-22-3p, 513a-5p and 625-5p may impact the pathogenesis of dust mite-induced pediatric asthma. Int J Mol Med. 2016 Aug; 38(2):446-56. PMID: 27277384; PMCID: PMC4935459.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  46. Sun M, Lu Q. MicroRNA regulation of airway smooth muscle function. Biol Chem. 2016 06 01; 397(6):507-11. PMID: 26812790.
    Citations: 1     Fields:    Translation:HumansAnimals
  47. Rodosthenous RS, Coull BA, Lu Q, Vokonas PS, Schwartz JD, Baccarelli AA. Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals. Part Fibre Toxicol. 2016 Mar 08; 13:13. PMID: 26956024; PMCID: PMC4782360.
    Citations: 39     Fields:    Translation:HumansCellsPHPublic Health
  48. Himes BE, Jiang X, Wagner P, Hu R, Wang Q, Klanderman B, Whitaker RM, Duan Q, Lasky-Su J, Nikolos C, Jester W, Johnson M, Panettieri RA, Tantisira KG, Weiss ST, Lu Q. RNA-Seq transcriptome profiling identifies CRISPLD2 as a glucocorticoid responsive gene that modulates cytokine function in airway smooth muscle cells. PLoS One. 2014; 9(6):e99625. PMID: 24926665.
    Citations: 71     Fields:    Translation:HumansCells
  49. Hu R, Pan W, Fedulov AV, Jester W, Jones MR, Weiss ST, Panettieri RA, Tantisira K, Lu Q. MicroRNA-10a controls airway smooth muscle cell proliferation via direct targeting of the PI3 kinase pathway. FASEB J. 2014 May; 28(5):2347-57. PMID: 24522205.
    Citations: 37     Fields:    Translation:HumansCells
  50. Pan WC, Seow WJ, Kile ML, Hoffman EB, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lu Q, Christiani DC. Association of low to moderate levels of arsenic exposure with risk of type 2 diabetes in Bangladesh. Am J Epidemiol. 2013 Nov 15; 178(10):1563-70. PMID: 24049161.
    Citations: 42     Fields:    Translation:HumansPHPublic Health
  51. Pan WC, Kile ML, Seow WJ, Lin X, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lu Q, Christiani DC. Genetic susceptible locus in NOTCH2 interacts with arsenic in drinking water on risk of type 2 diabetes. PLoS One. 2013; 8(8):e70792. PMID: 23967108.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  52. Himes BE, Jiang X, Hu R, Wu AC, Lasky-Su JA, Klanderman BJ, Ziniti J, Senter-Sylvia J, Lima JJ, Irvin CG, Peters SP, Meyers DA, Bleecker ER, Kubo M, Tamari M, Nakamura Y, Szefler SJ, Lemanske RF, Zeiger RS, Strunk RC, Martinez FD, Hanrahan JP, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Panettieri RA, Markezich A, Israel E, Carey VJ, Tantisira KG, Litonjua AA, Lu Q, Weiss ST. Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet. 2012 Jul; 8(7):e1002824. PMID: 22792082.
    Citations: 50     Fields:    Translation:HumansCells
  53. Zhou H, DeLoid G, Browning E, Gregory DJ, Tan F, Bedugnis AS, Imrich A, Koziel H, Kramnik I, Lu Q, Kobzik L. Genome-wide RNAi screen in IFN-?-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis. PLoS One. 2012; 7(2):e31752. PMID: 22359626.
    Citations: 12     Fields:    Translation:HumansCells
  54. Nabhan JF, Hu R, Oh RS, Cohen SN, Lu Q. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc Natl Acad Sci U S A. 2012 Mar 13; 109(11):4146-51. PMID: 22315426.
    Citations: 265     Fields:    Translation:HumansCells
  55. Jiang X, Pan H, Nabhan JF, Krishnan R, Koziol-White C, Panettieri RA, Lu Q. A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in ß2-adrenergic receptor internalization and down-regulation. FASEB J. 2012 May; 26(5):1995-2007. PMID: 22278941.
    Citations: 7     Fields:    Translation:HumansCells
  56. Oh RS, Pan WC, Yalcin A, Zhang H, Guilarte TR, Hotamisligil GS, Christiani DC, Lu Q. Functional RNA interference (RNAi) screen identifies system A neutral amino acid transporter 2 (SNAT2) as a mediator of arsenic-induced endoplasmic reticulum stress. J Biol Chem. 2012 Feb 17; 287(8):6025-34. PMID: 22215663; PMCID: PMC3285369.
    Citations: 16     Fields:    Translation:HumansCells
  57. Zhou X, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AM, Silverman EK. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet. 2012 Mar 15; 21(6):1325-35. PMID: 22140090.
    Citations: 82     Fields:    Translation:HumansCells
  58. Nabhan JF, Pan H, Lu Q. Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor. EMBO Rep. 2010 Aug; 11(8):605-11. PMID: 20559325.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
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