Harvard Catalyst Profiles

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Eric Joseph Rubin, M.D., Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI143788 (FLYNN, JOANNE L.) Feb 6, 2019 - Jan 31, 2024
    NIH/NIAID
    Development of a Self Inactivating, Highly Effective TB Vaccine
    Role: Co-Principal Investigator
  2. R21AI116142 (PYM, ALEXANDER S) Feb 25, 2015 - Jan 31, 2017
    NIH/NIAID
    Fate of M. tuberculosis Antibiotic Survivors
    Role: Co-Principal Investigator
  3. U19AI109755 (MURRAY, MEGAN B) Mar 1, 2014 - Feb 28, 2019
    NIH/NIAID
    Integrated discovery and development of innovative TB Diagnostics
    Role: Co-Principal Investigator
  4. U19AI107774 (RUBIN, ERIC J.) Jul 2, 2013 - Jun 30, 2018
    NIH/NIAID
    Decoding the roles of critical genes of unknown function in M. tuberculosis
    Role: Co-Principal Investigator
  5. P01AI095208 (SACCHETTINI, JAMES C) Sep 1, 2012 - Aug 31, 2016
    NIH/NIAID
    Structure-based Discovery of Critical Vulnerabilities of Micobacteria
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rubin EJ, Baden LR, Morrissey S. Audio Interview: Practical Measures to Help Prevent Covid-19. N Engl J Med. 2020 Mar 26; 382(13):e32. PMID: 32212540.
    Citations:    
  2. Rubin EJ, Baden LR, Morrissey S. Audio Interview: New Research on Possible Treatments for Covid-19. N Engl J Med. 2020 03 19; 382(12):e30. PMID: 32187489.
    Citations:    
  3. Baden LR, Rubin EJ. Covid-19 - The Search for Effective Therapy. N Engl J Med. 2020 Mar 18. PMID: 32187463.
    Citations:    
  4. Rubin EJ, Baden LR, Morrissey S. Audio Interview: Making Decisions about Covid-19 Testing and Treatment for Your Patients. N Engl J Med. 2020 03 12; 382(11):e25. PMID: 32160684.
    Citations:    
  5. Rubin EJ, Baden LR, Morrissey S. Audio Interview: What Clinicians Need to Know in Diagnosing and Treating Covid-19. N Engl J Med. 2020 03 05; 382(10):e19. PMID: 32130833.
    Citations:    
  6. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. A disclosure form for work submitted to medical journals - a proposal from the International Committee of Medical Journal Editors. Bull World Health Organ. 2020 Mar 01; 98(3):153-154. PMID: 32132746.
    Citations:    
  7. Rubin EJ, Baden LR, Morrissey S. Audio Interview: Preparing for the Spread of Covid-19. N Engl J Med. 2020 02 27; 382(9):e18. PMID: 32101683.
    Citations:    
  8. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. A disclosure form for work submitted to medical journals: a proposal from the International Committee of Medical Journal Editors. N Z Med J. 2020 Feb 07; 133(1509):6-8. PMID: 32027633.
    Citations:    
  9. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. Ugeskr Laeger. 2020 Feb 03; 182(6). PMID: 32089150.
    Citations:    
  10. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. A Disclosure Form for Work Submitted to Medical Journals: a Proposal from the International Committee of Medical Journal Editors. J Korean Med Sci. 2020 Feb 03; 35(4):e39. PMID: 31997616.
    Citations:    
  11. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. Dan Med J. 2020 02; 67(2). PMID: 32053482.
    Citations:    
  12. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. A Disclosure Form for Work Submitted to Medical Journals: A Proposal From the International Committee of Medical Journal Editors. Ann Intern Med. 2020 Jan 28. PMID: 31986521.
    Citations:    
  13. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. A disclosure form for work submitted to medical journals: a proposal from the International Committee of Medical Journal Editors. Lancet. 2020 Jan 27. PMID: 31999953.
    Citations:    
  14. Rubin EJ, Baden LR, Morrissey S, Campion EW. Medical Journals and the 2019-nCoV Outbreak. N Engl J Med. 2020 02 27; 382(9):866. PMID: 31986242.
    Citations:    
  15. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. A Disclosure Form for Work Submitted to Medical Journals - A Proposal from the International Committee of Medical Journal Editors. N Engl J Med. 2020 02 13; 382(7):667-668. PMID: 31986241.
    Citations:    
  16. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. A Disclosure Form for Work Submitted to Medical Journals: A Proposal From the International Committee of Medical Journal Editors. JAMA. 2020 Jan 27. PMID: 31986524.
    Citations:    
  17. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. A Disclosure Form for Work Submitted to Medical Journals-A Proposal From the International Committee of Medical Journal Editors. Ethiop J Health Sci. 2020 01; 30(1):1-4. PMID: 32116426.
    Citations:    
  18. Taichman DB, Backus J, Baethge C, Bauchner H, Flanagin A, Florenzano F, Frizelle FA, Godlee F, Gollogly L, Haileamlak A, Hong ST, Horton R, James A, Laine C, Miller PW, Pinborg A, Rubin EJ, Sahni P. A Disclosure Form for Work Submitted to Medical Journals. Dtsch Arztebl Int. 2020; 117(5):61-63. PMID: 32070471.
    Citations:    
  19. Lee TH, Mohta NS, Prewitt E, Campion EW, Morrissey S, Drazen JM, Rubin EJ. NEJM Catalyst Innovations in Care Delivery - A New Journal Leading the Transformation of Health Care Delivery. N Engl J Med. 2020 01 02; 382(1):80-81. PMID: 31845769.
    Citations:    
  20. Dragset MS, Ioerger TR, Loevenich M, Haug M, Sivakumar N, Marstad A, Cardona PJ, Klinkenberg G, Rubin EJ, Steigedal M, Flo TH. Global Assessment of Mycobacterium avium subsp. hominissuis Genetic Requirement for Growth and Virulence. mSystems. 2019 Dec 10; 4(6). PMID: 31822597.
    Citations:    
  21. Dulberger CL, Rubin EJ, Boutte CC. The mycobacterial cell envelope - a moving target. Nat Rev Microbiol. 2020 Jan; 18(1):47-59. PMID: 31728063.
    Citations:    
  22. Ruetz M, Campanello GC, Purchal M, Shen H, McDevitt L, Gouda H, Wakabayashi S, Zhu J, Rubin EJ, Warncke K, Mootha VK, Koutmos M, Banerjee R. Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. Science. 2019 11 01; 366(6465):589-593. PMID: 31672889.
    Citations:    
  23. Poce G, Consalvi S, Venditti G, Alfonso S, Desideri N, Fernandez-Menendez R, Bates RH, Ballell L, Barros Aguirre D, Rullas J, De Logu A, Gardner M, Ioerger TR, Rubin EJ, Biava M. Novel Pyrazole-Containing Compounds Active against Mycobacterium tuberculosis. ACS Med Chem Lett. 2019 Oct 10; 10(10):1423-1429. PMID: 31620228.
    Citations:    
  24. Rubin EJ. Changing Principals, Keeping Principles. N Engl J Med. 2019 09 12; 381(11):1069-1070. PMID: 31509679.
    Citations:    
  25. Buter J, Cheng TY, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN, Layre E, Ramnarine AK, Mayfield JA, Young DC, Jezek Martinot A, Siddiqi N, Wakabayashi S, Botella H, Calderon R, Murray M, Ehrt S, Snider BB, Reed MB, Oldfield E, Tan S, Rubin EJ, Behr MA, van der Wel NN, Minnaard AJ, Moody DB. Mycobacterium tuberculosis releases an antacid that remodels phagosomes. Nat Chem Biol. 2019 09; 15(9):889-899. PMID: 31427817.
    Citations:    
  26. Dragset MS, Ioerger TR, Zhang YJ, Mærk M, Ginbot Z, Sacchettini JC, Flo TH, Rubin EJ, Steigedal M. Genome-wide Phenotypic Profiling Identifies and Categorizes Genes Required for Mycobacterial Low Iron Fitness. Sci Rep. 2019 Aug 06; 9(1):11394. PMID: 31388080.
    Citations:    
  27. Mir M, Prisic S, Kang CM, Lun S, Guo H, Murry JP, Rubin EJ, Husson RN. Correction for Mir et al., "Mycobacterial Gene cuvA Is Required for Optimal Nutrient Utilization and Virulence". Infect Immun. 2019 Aug; 87(8). PMID: 31337689.
    Citations:    
  28. Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT. Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes. Nature. 2019 07; 571(7763):72-78. PMID: 31217586.
    Citations:    
  29. Wu KJ, Boutte CC, Ioerger TR, Rubin EJ. Mycobacterium smegmatis HtrA Blocks the Toxic Activity of a Putative Cell Wall Amidase. Cell Rep. 2019 05 21; 27(8):2468-2479.e3. PMID: 31116989.
    Citations:    
  30. Landeta C, McPartland L, Tran NQ, Meehan BM, Zhang Y, Tanweer Z, Wakabayashi S, Rock J, Kim T, Balasubramanian D, Audette R, Toosky M, Pinkham J, Rubin EJ, Lory S, Pier G, Boyd D, Beckwith J. Inhibition of Pseudomonas aeruginosa and Mycobacterium tuberculosis disulfide bond forming enzymes. Mol Microbiol. 2019 04; 111(4):918-937. PMID: 30556355.
    Citations:    Fields:    
  31. Baranowski C, Rego EH, Rubin EJ. The Dream of a Mycobacterium. Microbiol Spectr. 2019 03; 7(2). PMID: 31025625.
    Citations:    
  32. Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Le Van H, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P. Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection. Am J Respir Crit Care Med. 2019 03 01; 199(5):564-571. PMID: 30335466.
    Citations:    Fields:    
  33. Gustine JN, Au MB, Haserick JR, Hett EC, Rubin EJ, Gibson FC, Deng LL. Cell Wall Hydrolytic Enzymes Enhance Antimicrobial Drug Activity Against Mycobacterium. Curr Microbiol. 2019 Apr; 76(4):398-409. PMID: 30603964.
    Citations:    Fields:    
  34. Bedi G, Hao X, Van Dam NT, Cooper ZD, Rubin E, Vadhan NP, Marino L, Haney M. Social motivational processing and interpersonal function in aging cocaine smokers. Addict Biol. 2019 09; 24(5):1044-1055. PMID: 30328665.
    Citations:    Fields:    
  35. Baranowski C, Welsh MA, Sham LT, Eskandarian HA, Lim HC, Kieser KJ, Wagner JC, McKinney JD, Fantner GE, Ioerger TR, Walker S, Bernhardt TG, Rubin EJ, Rego EH. Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape. Elife. 2018 10 16; 7. PMID: 30324906.
    Citations: 2     Fields:    
  36. Rubin EJ. Of MICs and Men. N Engl J Med. 2018 08 30; 379(9):882-883. PMID: 30157402.
    Citations:    Fields:    Translation:Humans
  37. Chaudhuri S, Li L, Zimmerman M, Chen Y, Chen YX, Toosky MN, Gardner M, Pan M, Li YY, Kawaji Q, Zhu JH, Su HW, Martinot AJ, Rubin EJ, Dartois VA, Javid B. Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation. Elife. 2018 08 28; 7. PMID: 30152756.
    Citations:    Fields:    Translation:AnimalsCells
  38. Crofts AA, Giovanetti SM, Rubin EJ, Poly FM, Gutiérrez RL, Talaat KR, Porter CK, Riddle MS, DeNearing B, Brubaker J, Maciel M, Alcala AN, Chakraborty S, Prouty MG, Savarino SJ, Davies BW, Trent MS. Enterotoxigenic E. coli virulence gene regulation in human infections. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):E8968-E8976. PMID: 30126994.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  39. Rubin EJ. TB diagnosis from the Dark Ages to fluorescence. Nat Microbiol. 2018 Mar; 3(3):268-269. PMID: 29463926.
    Citations: 2     Fields:    
  40. Wu KJ, Zhang J, Baranowski C, Leung V, Rego EH, Morita YS, Rubin EJ, Boutte CC. Characterization of Conserved and Novel Septal Factors in Mycobacterium smegmatis. J Bacteriol. 2018 03 15; 200(6). PMID: 29311277.
    Citations: 1     Fields:    Translation:Cells
  41. Rubin EJ, Fortune SM. Misunderstanding the goals of animal research. BMJ. 2018 02 21; 360:k759. PMID: 29467126.
    Citations:    Fields:    Translation:Animals
  42. Franchina FA, Mellors TR, Aliyeva M, Wagner J, Daphtary N, Lundblad LKA, Fortune SM, Rubin EJ, Hill JE. Towards the use of breath for detecting mycobacterial infection: a case study in a murine model. J Breath Res. 2018 02 07; 12(2):026008. PMID: 29219122.
    Citations:    Fields:    
  43. Laencina L, Dubois V, Le Moigne V, Viljoen A, Majlessi L, Pritchard J, Bernut A, Piel L, Roux AL, Gaillard JL, Lombard B, Loew D, Rubin EJ, Brosch R, Kremer L, Herrmann JL, Girard-Misguich F. Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E1002-E1011. PMID: 29343644.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  44. Guinn KM, Rubin EJ. Tuberculosis: Just the FAQs. mBio. 2017 12 19; 8(6). PMID: 29259086.
    Citations:    Fields:    Translation:Humans
  45. Lehmann J, Cheng TY, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Sacchettini JC, Moody DB, Rubin EJ, Sieber SA. An Antibacterial ß-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis. Angew Chem Int Ed Engl. 2018 01 02; 57(1):348-353. PMID: 29067779.
    Citations: 1     Fields:    
  46. Baden LR, Rubin EJ, Morrissey S, Farrar JJ, Drazen JM. We Can Do Better - Improving Outcomes in the Midst of an Emergency. N Engl J Med. 2017 10 12; 377(15):1482-1484. PMID: 29020598.
    Citations:    Fields:    Translation:Humans
  47. Kim ES, Bruinooge SS, Roberts S, Ison G, Lin NU, Gore L, Uldrick TS, Lichtman SM, Roach N, Beaver JA, Sridhara R, Hesketh PJ, Denicoff AM, Garrett-Mayer E, Rubin E, Multani P, Prowell TM, Schenkel C, Kozak M, Allen J, Sigal E, Schilsky RL. Broadening Eligibility Criteria to Make Clinical Trials More Representative: American Society of Clinical Oncology and Friends of Cancer Research Joint Research Statement. J Clin Oncol. 2017 Nov 20; 35(33):3737-3744. PMID: 28968170.
    Citations: 8     Fields:    Translation:Humans
  48. Gore L, Ivy SP, Balis FM, Rubin E, Thornton K, Donoghue M, Roberts S, Bruinooge S, Ersek J, Goodman N, Schenkel C, Reaman G. Modernizing Clinical Trial Eligibility: Recommendations of the American Society of Clinical Oncology-Friends of Cancer Research Minimum Age Working Group. J Clin Oncol. 2017 Nov 20; 35(33):3781-3787. PMID: 28968169.
    Citations:    Fields:    Translation:Humans
  49. Yadon AN, Maharaj K, Adamson JH, Lai YP, Sacchettini JC, Ioerger TR, Rubin EJ, Pym AS. A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide. Nat Commun. 2017 09 19; 8(1):588. PMID: 28928454.
    Citations: 3     Fields:    Translation:HumansCells
  50. Yee M, Klinzing D, Wei JR, Gengenbacher M, Rubin EJ, Chien JY, Hsueh PR, Dick T. Draft Genome Sequence of Mycobacterium avium 11. Genome Announc. 2017 Aug 10; 5(32). PMID: 28798178.
    Citations: 1     
  51. Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell. 2017 Jul 13; 170(2):249-259.e25. PMID: 28669536.
    Citations: 7     Fields:    Translation:AnimalsCells
  52. Rubin EJ. Reviving a Drug for Tuberculosis? N Engl J Med. 2017 Jun 08; 376(23):2292-2294. PMID: 28591540.
    Citations:    Fields:    Translation:HumansAnimalsCells
  53. Rego EH, Audette RE, Rubin EJ. Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity. Nature. 2017 06 01; 546(7656):153-157. PMID: 28569798.
    Citations: 10     Fields:    Translation:Cells
  54. Yee M, Klinzing D, Wei JR, Gengenbacher M, Rubin EJ, Dick T. Draft Genome Sequence of Mycobacterium abscessus Bamboo. Genome Announc. 2017 May 18; 5(20). PMID: 28522728.
    Citations: 5     
  55. Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM. Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nat Microbiol. 2017 Feb 06; 2:16274. PMID: 28165460.
    Citations: 7     Fields:    Translation:Cells
  56. DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. mBio. 2017 01 17; 8(1). PMID: 28096490.
    Citations: 15     Fields:    Translation:Cells
  57. Hirsch FR, McElhinny A, Stanforth D, Ranger-Moore J, Jansson M, Kulangara K, Richardson W, Towne P, Hanks D, Vennapusa B, Mistry A, Kalamegham R, Averbuch S, Novotny J, Rubin E, Emancipator K, McCaffery I, Williams JA, Walker J, Longshore J, Tsao MS, Kerr KM. PD-L1 Immunohistochemistry Assays for Lung Cancer: Results from Phase 1 of the Blueprint PD-L1 IHC Assay Comparison Project. J Thorac Oncol. 2017 02; 12(2):208-222. PMID: 27913228.
    Citations:    
  58. Baric RS, Crosson S, Damania B, Miller SI, Rubin EJ. Next-Generation High-Throughput Functional Annotation of Microbial Genomes. mBio. 2016 10 04; 7(5). PMID: 27703071.
    Citations: 2     Fields:    
  59. Yamada HY, Kumar G, Zhang Y, Rubin E, Lightfoot S, Dai W, Rao CV. Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung. Oncogenesis. 2016 Aug 15; 5(8):e256. PMID: 27526110.
    Citations: 4     
  60. Baranowski C, Rubin EJ. Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park? J Med Chem. 2016 07 14; 59(13):6025-6. PMID: 27322073.
    Citations: 1     Fields:    Translation:HumansCells
  61. Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ. A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis. Elife. 2016 06 15; 5. PMID: 27304077.
    Citations: 6     Fields:    Translation:Cells
  62. Filippova EV, Kieser KJ, Luan CH, Wawrzak Z, Kiryukhina O, Rubin EJ, Anderson WF. Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance. FEBS J. 2016 06; 283(12):2206-18. PMID: 27101811.
    Citations: 2     Fields:    Translation:HumansCells
  63. Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE, Mann M, Dartois V, Rubin EJ. Inflammatory signaling in human tuberculosis granulomas is spatially organized. Nat Med. 2016 05; 22(5):531-8. PMID: 27043495.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  64. Raju RM, Raju SM, Zhao Y, Rubin EJ. Leveraging Advances in Tuberculosis Diagnosis and Treatment to Address Nontuberculous Mycobacterial Disease. Emerg Infect Dis. 2016 Mar; 22(3):365-9. PMID: 26886068.
    Citations: 5     Fields:    Translation:HumansCells
  65. Rubin EJ, Greene MF, Baden LR. Zika Virus and Microcephaly. N Engl J Med. 2016 Mar 10; 374(10):984-5. PMID: 26862812.
    Citations: 32     Fields:    Translation:HumansCells
  66. Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ. Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis. PLoS Pathog. 2016 Jan; 12(1):e1005351. PMID: 26751071.
    Citations: 10     Fields:    Translation:AnimalsCells
  67. Ivanova A, Anderson KM, Rosner GL, Rubin E. Comment. Stat Biopharm Res. 2015; 7(4):357-358. PMID: 30416674.
    Citations:    
  68. Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ. Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):13087-92. PMID: 26438867.
    Citations: 14     Fields:    Translation:Cells
  69. Dragset MS, Barczak AK, Kannan N, Mærk M, Flo TH, Valla S, Rubin EJ, Steigedal M. Benzoic Acid-Inducible Gene Expression in Mycobacteria. PLoS One. 2015; 10(9):e0134544. PMID: 26348349.
    Citations: 1     Fields:    Translation:HumansCells
  70. Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ. Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. PLoS Pathog. 2015 Jun; 11(6):e1005010. PMID: 26114871.
    Citations: 8     Fields:    Translation:Cells
  71. Moreira W, Ngan GJ, Low JL, Poulsen A, Chia BC, Ang MJ, Yap A, Fulwood J, Lakshmanan U, Lim J, Khoo AY, Flotow H, Hill J, Raju RM, Rubin EJ, Dick T. Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria. mBio. 2015 May 05; 6(3):e00253-15. PMID: 25944857.
    Citations: 14     Fields:    Translation:Cells
  72. Foltin RW, Haney M, Rubin E, Reed SC, Vadhan N, Balter R, Evans SM. Development of translational preclinical models in substance abuse: Effects of cocaine administration on cocaine choice in humans and non-human primates. Pharmacol Biochem Behav. 2015 Jul; 134:12-21. PMID: 25933796.
    Citations: 12     Fields:    Translation:HumansAnimals
  73. Madigan CA, Martinot AJ, Wei JR, Madduri A, Cheng TY, Young DC, Layre E, Murry JP, Rubin EJ, Moody DB. Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis. PLoS Pathog. 2015 Mar; 11(3):e1004792. PMID: 25815898.
    Citations: 10     Fields:    Translation:AnimalsCells
  74. Akopian T, Kandror O, Tsu C, Lai JH, Wu W, Liu Y, Zhao P, Park A, Wolf L, Dick LR, Rubin EJ, Bachovchin W, Goldberg AL. Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity. J Biol Chem. 2015 Apr 24; 290(17):11008-20. PMID: 25759383.
    Citations: 6     Fields:    Translation:Cells
  75. Baer CE, Rubin EJ, Sassetti CM. New insights into TB physiology suggest untapped therapeutic opportunities. Immunol Rev. 2015 Mar; 264(1):327-43. PMID: 25703570.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  76. Landeta C, Blazyk JL, Hatahet F, Meehan BM, Eser M, Myrick A, Bronstain L, Minami S, Arnold H, Ke N, Rubin EJ, Furie BC, Furie B, Beckwith J, Dutton R, Boyd D. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat Chem Biol. 2015 Apr; 11(4):292-8. PMID: 25686372.
    Citations: 8     Fields:    Translation:Cells
  77. Ingelfinger JR, Rubin EJ. The HIV-positive transplant donor--change born of necessity. N Engl J Med. 2015 Feb 12; 372(7):663-5. PMID: 25671260.
    Citations: 1     Fields:    Translation:Humans
  78. Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ. A novel antimycobacterial compound acts as an intracellular iron chelator. Antimicrob Agents Chemother. 2015 Apr; 59(4):2256-64. PMID: 25645825.
    Citations: 5     Fields:    Translation:Cells
  79. Rodionova IA, Zuccola HJ, Sorci L, Aleshin AE, Kazanov MD, Ma CT, Sergienko E, Rubin EJ, Locher CP, Osterman AL. Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery. J Biol Chem. 2015 Mar 20; 290(12):7693-706. PMID: 25631047.
    Citations:    Fields:    Translation:Cells
  80. Rubin EJ, Herrera CM, Crofts AA, Trent MS. PmrD is required for modifications to escherichia coli endotoxin that promote antimicrobial resistance. Antimicrob Agents Chemother. 2015 Apr; 59(4):2051-61. PMID: 25605366.
    Citations: 9     Fields:    Translation:Cells
  81. Drazen JM, Campion EW, Rubin EJ, Morrissey S, Baden LR. Ebola in West Africa at one year--from ignorance to fear to roadblocks. N Engl J Med. 2015 Feb 05; 372(6):563-4. PMID: 25539445.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  82. Rubin EJ, Baden LR. Out of Africa--caring for patients with Ebola. N Engl J Med. 2014 Dec 18; 371(25):2430-2. PMID: 25390461.
    Citations: 4     Fields:    Translation:HumansCells
  83. Pritchard JR, Chao MC, Abel S, Davis BM, Baranowski C, Zhang YJ, Rubin EJ, Waldor MK. ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing. PLoS Genet. 2014 Nov; 10(11):e1004782. PMID: 25375795.
    Citations: 35     Fields:    Translation:Cells
  84. Drazen JM, Kanapathipillai R, Campion EW, Rubin EJ, Hammer SM, Morrissey S, Baden LR. Ebola and quarantine. N Engl J Med. 2014 Nov 20; 371(21):2029-30. PMID: 25347231.
    Citations: 17     Fields:    Translation:HumansPHPublic Health
  85. Baden LR, Kanapathipillai R, Campion EW, Morrissey S, Rubin EJ, Drazen JM. Ebola--an ongoing crisis. N Engl J Med. 2014 Oct 09; 371(15):1458-9. PMID: 25237780.
    Citations: 10     Fields:    Translation:HumansCellsPHPublic Health
  86. Seymour JF, Kim DW, Rubin E, Haregewoin A, Clark J, Watson P, Hughes T, Dufva I, Jimenez JL, Mahon FX, Rousselot P, Cortes J, Martinelli G, Papayannidis C, Nagler A, Giles FJ. A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia. Blood Cancer J. 2014 Aug 15; 4:e238. PMID: 25127392.
    Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
  87. Santa Maria JP, Sadaka A, Moussa SH, Brown S, Zhang YJ, Rubin EJ, Gilmore MS, Walker S. Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12510-5. PMID: 25104751.
    Citations: 17     Fields:    Translation:Cells
  88. Trauner A, Sassetti CM, Rubin EJ. Genetic Strategies for Identifying New Drug Targets. Microbiol Spectr. 2014 Aug; 2(4):MGM2-0030-2013. PMID: 26104208.
    Citations: 1     Fields:    Translation:Cells
  89. Mir M, Prisic S, Kang CM, Lun S, Guo H, Murry JP, Rubin EJ, Husson RN. Mycobacterial gene cuvA is required for optimal nutrient utilization and virulence. Infect Immun. 2014 Oct; 82(10):4104-17. PMID: 25047842.
    Citations: 3     Fields:    Translation:AnimalsCells
  90. Kieser KJ, Rubin EJ. How sisters grow apart: mycobacterial growth and division. Nat Rev Microbiol. 2014 Aug; 12(8):550-62. PMID: 24998739.
    Citations: 44     Fields:    Translation:Cells
  91. Mavrici D, Marakalala MJ, Holton JM, Prigozhin DM, Gee CL, Zhang YJ, Rubin EJ, Alber T. Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8037-42. PMID: 24843173.
    Citations: 16     Fields:    Translation:Cells
  92. Ngubane NA, Gresh L, Pym A, Rubin EJ, Khati M. Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX. Biochem Biophys Res Commun. 2014 Jun 20; 449(1):114-9. PMID: 24813997.
    Citations: 5     Fields:    Translation:Cells
  93. Siegrist MS, Steigedal M, Ahmad R, Mehra A, Dragset MS, Schuster BM, Philips JA, Carr SA, Rubin EJ. Mycobacterial Esx-3 requires multiple components for iron acquisition. mBio. 2014 May 06; 5(3):e01073-14. PMID: 24803520.
    Citations: 18     Fields:    Translation:Cells
  94. Raju RM, Jedrychowski MP, Wei JR, Pinkham JT, Park AS, O'Brien K, Rehren G, Schnappinger D, Gygi SP, Rubin EJ. Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis. PLoS Pathog. 2014 Mar; 10(3):e1003994. PMID: 24603869.
    Citations: 18     Fields:    Translation:Cells
  95. Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 2014 Feb; 10(2):e1003946. PMID: 24586159.
    Citations: 61     Fields:    Translation:AnimalsCells
  96. Rodionova IA, Schuster BM, Guinn KM, Sorci L, Scott DA, Li X, Kheterpal I, Shoen C, Cynamon M, Locher C, Rubin EJ, Osterman AL. Metabolic and bactericidal effects of targeted suppression of NadD and NadE enzymes in mycobacteria. mBio. 2014 Feb 18; 5(1). PMID: 24549842.
    Citations: 7     Fields:    Translation:Cells
  97. Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, Rubin EJ, Alber T, Moody DB. Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):2978-83. PMID: 24516143.
    Citations: 16     Fields:    Translation:Cells
  98. Rubin EJ. Troubles with tuberculosis prevention. N Engl J Med. 2014 Jan 23; 370(4):375-6. PMID: 24450896.
    Citations: 2     Fields:    Translation:Humans
  99. Rubin EJ, O'Brien JP, Ivanov PL, Brodbelt JS, Trent MS. Identification of a broad family of lipid A late acyltransferases with non-canonical substrate specificity. Mol Microbiol. 2014 Mar; 91(5):887-99. PMID: 24372821.
    Citations: 7     Fields:    Translation:Cells
  100. Javid B, Sorrentino F, Toosky M, Zheng W, Pinkham JT, Jain N, Pan M, Deighan P, Rubin EJ. Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1132-7. PMID: 24395793.
    Citations: 36     Fields:    Translation:Cells
  101. Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, Sacchettini JC, Behar SM, Rubin EJ. Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell. 2013 Dec 05; 155(6):1296-308. PMID: 24315099.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  102. Ngubane NA, Gresh L, Ioerger TR, Sacchettini JC, Zhang YJ, Rubin EJ, Pym A, Khati M. High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria. PLoS One. 2013; 8(11):e77844. PMID: 24265677.
    Citations: 7     Fields:    Translation:Cells
  103. Jean-Francois FL, Dai J, Yu L, Myrick A, Rubin E, Fajer PG, Song L, Zhou HX, Cross TA. Binding of MgtR, a Salmonella transmembrane regulatory peptide, to MgtC, a Mycobacterium tuberculosis virulence factor: a structural study. J Mol Biol. 2014 Jan 23; 426(2):436-46. PMID: 24140750.
    Citations: 5     Fields:    Translation:Cells
  104. Zheng J, Rubin EJ, Bifani P, Mathys V, Lim V, Au M, Jang J, Nam J, Dick T, Walker JR, Pethe K, Camacho LR. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013 Oct 4; 288(40):28951. PMID: 24098010.
    Citations:    
  105. Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE, Sherman DR, Parish T, Sacchettini JC. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One. 2013; 8(9):e75245. PMID: 24086479.
    Citations: 49     Fields:    Translation:Cells
  106. Farhat MR, Shapiro BJ, Kieser KJ, Sultana R, Jacobson KR, Victor TC, Warren RM, Streicher EM, Calver A, Sloutsky A, Kaur D, Posey JE, Plikaytis B, Oggioni MR, Gardy JL, Johnston JC, Rodrigues M, Tang PK, Kato-Maeda M, Borowsky ML, Muddukrishna B, Kreiswirth BN, Kurepina N, Galagan J, Gagneux S, Birren B, Rubin EJ, Lander ES, Sabeti PC, Murray M. Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis. Nat Genet. 2013 Oct; 45(10):1183-9. PMID: 23995135.
    Citations: 91     Fields:    Translation:Cells
  107. Chao MC, Pritchard JR, Zhang YJ, Rubin EJ, Livny J, Davis BM, Waldor MK. High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data. Nucleic Acids Res. 2013 Oct; 41(19):9033-48. PMID: 23901011.
    Citations: 47     Fields:    Translation:Cells
  108. Rubin EJ, Trent MS. Colonize, evade, flourish: how glyco-conjugates promote virulence of Helicobacter pylori. Gut Microbes. 2013 Nov-Dec; 4(6):439-53. PMID: 23859890.
    Citations: 5     Fields:    Translation:HumansCells
  109. Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):11565-70. PMID: 23798446.
    Citations: 16     Fields:    Translation:AnimalsCells
  110. Zheng J, Rubin EJ, Bifani P, Mathys V, Lim V, Au M, Jang J, Nam J, Dick T, Walker JR, Pethe K, Camacho LR. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013 Aug 09; 288(32):23447-56. PMID: 23779105.
    Citations: 27     Fields:    
  111. Comer SD, Mogali S, Saccone PA, Askalsky P, Martinez D, Walker EA, Jones JD, Vosburg SK, Cooper ZD, Roux P, Sullivan MA, Manubay JM, Rubin E, Pines A, Berkower EL, Haney M, Foltin RW. Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers. Neuropsychopharmacology. 2013 Nov; 38(12):2427-38. PMID: 23736314.
    Citations: 23     Fields:    Translation:Humans
  112. Zhang YJ, Rubin EJ. Feast or famine: the host-pathogen battle over amino acids. Cell Microbiol. 2013 Jul; 15(7):1079-87. PMID: 23521858.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  113. Chao MC, Kieser KJ, Minami S, Mavrici D, Aldridge BB, Fortune SM, Alber T, Rubin EJ. Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria. PLoS Pathog. 2013 Feb; 9(2):e1003197. PMID: 23468634.
    Citations: 10     Fields:    Translation:Cells
  114. Hickman HD, Reynoso GV, Ngudiankama BF, Rubin EJ, Magadán JG, Cush SS, Gibbs J, Molon B, Bronte V, Bennink JR, Yewdell JW. Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin. Cell Host Microbe. 2013 Feb 13; 13(2):155-68. PMID: 23414756.
    Citations: 22     Fields:    Translation:AnimalsCells
  115. DeJesus MA, Zhang YJ, Sassetti CM, Rubin EJ, Sacchettini JC, Ioerger TR. Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries. Bioinformatics. 2013 Mar 15; 29(6):695-703. PMID: 23361328.
    Citations: 17     Fields:    Translation:Cells
  116. De Leon J, Jiang G, Ma Y, Rubin E, Fortune S, Sun J. Mycobacterium tuberculosis ESAT-6 exhibits a unique membrane-interacting activity that is not found in its ortholog from non-pathogenic Mycobacterium smegmatis. J Biol Chem. 2012 Dec 28; 287(53):44184-91. PMID: 23150662.
    Citations: 24     Fields:    Translation:Cells
  117. Raju RM, Goldberg AL, Rubin EJ. Bacterial proteolytic complexes as therapeutic targets. Nat Rev Drug Discov. 2012 Oct; 11(10):777-89. PMID: 23023677.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  118. Zhang YJ, Ioerger TR, Huttenhower C, Long JE, Sassetti CM, Sacchettini JC, Rubin EJ. Global assessment of genomic regions required for growth in Mycobacterium tuberculosis. PLoS Pathog. 2012 Sep; 8(9):e1002946. PMID: 23028335.
    Citations: 80     Fields:    Translation:Cells
  119. Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H, Flynn J, Hafner R, Handley G, Hanekom W, van Helden P, Kaplan G, Kaufmann SH, Kim P, Lienhardt C, Mizrahi V, Rubin E, Schnappinger D, Sherman D, Thole J, Vandal O, Walzl G, Warner D, Wilkinson R, Young D. Detection and treatment of subclinical tuberculosis. Tuberculosis (Edinb). 2012 Nov; 92(6):447-52. PMID: 22819716.
    Citations: 11     Fields:    Translation:HumansCells
  120. Raju RM, Unnikrishnan M, Rubin DH, Krishnamoorthy V, Kandror O, Akopian TN, Goldberg AL, Rubin EJ. Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. PLoS Pathog. 2012 Feb; 8(2):e1002511. PMID: 22359499.
    Citations: 46     Fields:    Translation:AnimalsCells
  121. Akopian T, Kandror O, Raju RM, Unnikrishnan M, Rubin EJ, Goldberg AL. The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring. EMBO J. 2012 Mar 21; 31(6):1529-41. PMID: 22286948.
    Citations: 30     Fields:    Translation:Cells
  122. Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Sci Signal. 2012 Jan 24; 5(208):ra7. PMID: 22275220.
    Citations: 44     Fields:    Translation:Cells
  123. Madigan CA, Cheng TY, Layre E, Young DC, McConnell MJ, Debono CA, Murry JP, Wei JR, Barry CE, Rodriguez GM, Matsunaga I, Rubin EJ, Moody DB. Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1257-62. PMID: 22232695.
    Citations: 23     Fields:    Translation:Cells
  124. Cheng Y, Zhang Y, Zhang L, Ren X, Huber-Keener KJ, Liu X, Zhou L, Liao J, Keihack H, Yan L, Rubin E, Yang JM. MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Mol Cancer Ther. 2012 Jan; 11(1):154-64. PMID: 22057914.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  125. Hickman HD, Li L, Reynoso GV, Rubin EJ, Skon CN, Mays JW, Gibbs J, Schwartz O, Bennink JR, Yewdell JW. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med. 2011 Nov 21; 208(12):2511-24. PMID: 22042976.
    Citations: 33     Fields:    Translation:AnimalsCells
  126. La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, Botta M, De Logu A, Rubin EJ, De Rossi E. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob Agents Chemother. 2012 Jan; 56(1):324-31. PMID: 22024828.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  127. Keren I, Minami S, Rubin E, Lewis K. Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters. mBio. 2011; 2(3):e00100-11. PMID: 21673191.
    Citations: 81     Fields:    Translation:HumansCells
  128. Horsburgh CR, Rubin EJ. Clinical practice. Latent tuberculosis infection in the United States. N Engl J Med. 2011 Apr 14; 364(15):1441-8. PMID: 21488766.
    Citations: 54     Fields:    Translation:HumansCells
  129. Haney M, Rubin E, Foltin RW. Aripiprazole maintenance increases smoked cocaine self-administration in humans. Psychopharmacology (Berl). 2011 Aug; 216(3):379-87. PMID: 21373790.
    Citations: 24     Fields:    Translation:HumansCTClinical Trials
  130. Wei JR, Krishnamoorthy V, Murphy K, Kim JH, Schnappinger D, Alber T, Sassetti CM, Rhee KY, Rubin EJ. Depletion of antibiotic targets has widely varying effects on growth. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4176-81. PMID: 21368134.
    Citations: 51     Fields:    Translation:Cells
  131. Cheng Y, Ren X, Zhang Y, Patel R, Sharma A, Wu H, Robertson GP, Yan L, Rubin E, Yang JM. eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer Res. 2011 Apr 01; 71(7):2654-63. PMID: 21307130.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  132. Reed SC, Evans SM, Bedi G, Rubin E, Foltin RW. The effects of oral micronized progesterone on smoked cocaine self-administration in women. Horm Behav. 2011 Feb; 59(2):227-35. PMID: 21192940.
    Citations: 19     Fields:    Translation:Humans
  133. Kim JH, Wei JR, Wallach JB, Robbins RS, Rubin EJ, Schnappinger D. Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase. Nucleic Acids Res. 2011 Mar; 39(6):2210-20. PMID: 21075796.
    Citations: 23     Fields:    Translation:Cells
  134. Fortune SM, Rubin EJ. Host transcription in active and latent tuberculosis. Genome Biol. 2010; 11(9):135. PMID: 20920149.
    Citations: 1     Fields:    Translation:HumansCells
  135. Freundlich JS, Lalgondar M, Wei JR, Swanson S, Sorensen EJ, Rubin EJ, Sacchettini JC. The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2010 Sep; 90(5):298-300. PMID: 20739223.
    Citations: 6     Fields:    Translation:HumansCells
  136. Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 2010 Aug 10; 49(31):6746-60. PMID: 20565114.
    Citations: 15     Fields:    Translation:Cells
  137. Hett EC, Chao MC, Rubin EJ. Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria. PLoS Pathog. 2010 Jul 29; 6(7):e1001020. PMID: 20686708.
    Citations: 38     Fields:    Translation:Cells
  138. Sassetti CM, Rubin EJ. Relics of selection in the mycobacterial genome. Nat Genet. 2010 Jun; 42(6):476-8. PMID: 20502489.
    Citations: 1     Fields:    Translation:HumansCells
  139. Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC. Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. J Bacteriol. 2010 Jul; 192(14):3645-53. PMID: 20472797.
    Citations: 75     Fields:    Translation:Cells
  140. Chao MC, Rubin EJ. Letting sleeping dos lie: does dormancy play a role in tuberculosis? Annu Rev Microbiol. 2010; 64:293-311. PMID: 20825351.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  141. Dutton RJ, Wayman A, Wei JR, Rubin EJ, Beckwith J, Boyd D. Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):297-301. PMID: 20018758.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  142. Bitter W, Houben EN, Bottai D, Brodin P, Brown EJ, Cox JS, Derbyshire K, Fortune SM, Gao LY, Liu J, Gey van Pittius NC, Pym AS, Rubin EJ, Sherman DR, Cole ST, Brosch R. Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog. 2009 Oct; 5(10):e1000507. PMID: 19876390.
    Citations: 81     Fields:    Translation:Cells
  143. Siegrist MS, Unnikrishnan M, McConnell MJ, Borowsky M, Cheng TY, Siddiqi N, Fortune SM, Moody DB, Rubin EJ. Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18792-7. PMID: 19846780.
    Citations: 92     Fields:    Translation:AnimalsCells
  144. Murry JP, Pandey AK, Sassetti CM, Rubin EJ. Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity. J Infect Dis. 2009 Sep 01; 200(5):774-82. PMID: 19622047.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  145. Ranjbar S, Boshoff HI, Mulder A, Siddiqi N, Rubin EJ, Goldfeld AE. HIV-1 replication is differentially regulated by distinct clinical strains of Mycobacterium tuberculosis. PLoS One. 2009 Jul 01; 4(7):e6116. PMID: 19568431.
    Citations: 17     Fields:    Translation:HumansCells
  146. Rubin EJ. The granuloma in tuberculosis--friend or foe? N Engl J Med. 2009 Jun 04; 360(23):2471-3. PMID: 19494225.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  147. Reed SC, Haney M, Evans SM, Vadhan NP, Rubin E, Foltin RW. Cardiovascular and subjective effects of repeated smoked cocaine administration in experienced cocaine users. Drug Alcohol Depend. 2009 Jun 01; 102(1-3):102-7. PMID: 19303723.
    Citations: 13     Fields:    Translation:Humans
  148. Siegrist MS, Rubin EJ. Phage transposon mutagenesis. Methods Mol Biol. 2009; 465:311-23. PMID: 20560067.
    Citations: 2     Fields:    Translation:Cells
  149. Pandey AK, Raman S, Proff R, Joshi S, Kang CM, Rubin EJ, Husson RN, Sassetti CM. Nitrile-inducible gene expression in mycobacteria. Tuberculosis (Edinb). 2009 Jan; 89(1):12-6. PMID: 18801704.
    Citations: 27     Fields:    Translation:AnimalsCells
  150. Wei JR, Rubin EJ. The many roads to essential genes. Tuberculosis (Edinb). 2008 Aug; 88 Suppl 1:S19-24. PMID: 18762149.
    Citations: 5     Fields:    Translation:Cells
  151. Hett EC, Rubin EJ. Bacterial growth and cell division: a mycobacterial perspective. Microbiol Mol Biol Rev. 2008 Mar; 72(1):126-56, table of contents. PMID: 18322037.
    Citations: 92     Fields:    Translation:Cells
  152. Hett EC, Chao MC, Deng LL, Rubin EJ. A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor. PLoS Pathog. 2008 Feb 29; 4(2):e1000001. PMID: 18463693.
    Citations: 50     Fields:    Translation:Cells
  153. Philips JA, Porto MC, Wang H, Rubin EJ, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):3070-5. PMID: 18287038.
    Citations: 28     Fields:    Translation:AnimalsCells
  154. Rengarajan J, Murphy E, Park A, Krone CL, Hett EC, Bloom BR, Glimcher LH, Rubin EJ. Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):264-9. PMID: 18172199.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  155. Murry JP, Sassetti CM, Lane JM, Xie Z, Rubin EJ. Transposon site hybridization in Mycobacterium tuberculosis. Methods Mol Biol. 2008; 416:45-59. PMID: 18392960.
    Citations: 19     Fields:    Translation:Cells
  156. Sacchettini JC, Rubin EJ, Freundlich JS. Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis. Nat Rev Microbiol. 2008 Jan; 6(1):41-52. PMID: 18079742.
    Citations: 74     Fields:    Translation:HumansCells
  157. Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66. PMID: 18255326.
    Citations: 8     Fields:    Translation:AnimalsCells
  158. Farrow MF, Rubin EJ. Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein. J Bacteriol. 2008 Mar; 190(5):1783-91. PMID: 18156250.
    Citations: 21     Fields:    Translation:Cells
  159. Hett EC, Chao MC, Steyn AJ, Fortune SM, Deng LL, Rubin EJ. A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis. Mol Microbiol. 2007 Nov; 66(3):658-68. PMID: 17919286.
    Citations: 51     Fields:    Translation:Cells
  160. Fortune SM, Rubin EJ. The complex relationship between mycobacteria and macrophages: it's not all bliss. Cell Host Microbe. 2007 Jul 12; 2(1):5-6. PMID: 18005712.
    Citations: 5     Fields:    Translation:AnimalsCells
  161. Levin FR, Bisaga A, Raby W, Aharonovich E, Rubin E, Mariani J, Brooks DJ, Garawi F, Nunes EV. Effects of major depressive disorder and attention-deficit/hyperactivity disorder on the outcome of treatment for cocaine dependence. J Subst Abuse Treat. 2008 Jan; 34(1):80-9. PMID: 17574796.
    Citations: 9     Fields:    Translation:Humans
  162. Hart CL, Haney M, Vosburg SK, Rubin E, Foltin RW. Smoked cocaine self-administration is decreased by modafinil. Neuropsychopharmacology. 2008 Mar; 33(4):761-8. PMID: 17568397.
    Citations: 84     Fields:    Translation:HumansCTClinical Trials
  163. Charity JC, Costante-Hamm MM, Balon EL, Boyd DH, Rubin EJ, Dove SL. Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis. PLoS Pathog. 2007 Jun; 3(6):e84. PMID: 17571921.
    Citations: 77     Fields:    Translation:Cells
  164. Sassetti CM, Rubin EJ. The open book of infectious diseases. Nat Med. 2007 Mar; 13(3):279-80. PMID: 17342136.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  165. Sebastian S, Dillon ST, Lynch JG, Blalock LT, Balon E, Lee KT, Comstock LE, Conlan JW, Rubin EJ, Tzianabos AO, Kasper DL. A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity. Infect Immun. 2007 May; 75(5):2591-602. PMID: 17296751.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  166. Hart CL, Haney M, Collins ED, Rubin E, Foltin RW. Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance doses. Drug Alcohol Depend. 2007 Jan 12; 86(2-3):274-7. PMID: 16879931.
    Citations: 14     Fields:    Translation:Humans
  167. Joshi SM, Pandey AK, Capite N, Fortune SM, Rubin EJ, Sassetti CM. Characterization of mycobacterial virulence genes through genetic interaction mapping. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11760-5. PMID: 16868085.
    Citations: 66     Fields:    Translation:AnimalsCells
  168. Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol. 2006 Aug; 10(4):321-6. PMID: 16814591.
    Citations: 7     Fields:    Translation:Cells
  169. Diaz R, Siddiqi N, Rubin EJ. Detecting genetic variability among different Mycobacterium tuberculosis strains using DNA microarrays technology. Tuberculosis (Edinb). 2006 May-Jul; 86(3-4):314-8. PMID: 16644284.
    Citations: 4     Fields:    Translation:Cells
  170. Lane JM, Rubin EJ. Scaling down: a PCR-based method to efficiently screen for desired knockouts in a high density Mycobacterium tuberculosis picked mutant library. Tuberculosis (Edinb). 2006 May-Jul; 86(3-4):310-3. PMID: 16527544.
    Citations: 4     Fields:    Translation:Cells
  171. Fortune SM, Chase MR, Rubin EJ. Dividing oceans into pools: strategies for the global analysis of bacterial genes. Microbes Infect. 2006 May; 8(6):1631-6. PMID: 16697239.
    Citations: 1     Fields:    Translation:Cells
  172. Levin FR, Brooks DJ, Bisaga A, Raby W, Rubin E, Aharonovich E, Nunes EV. Severity of dependence and motivation for treatment: comparison of marijuana- and cocaine-dependent treatment seekers. J Addict Dis. 2006; 25(1):33-41. PMID: 16597571.
    Citations: 5     Fields:    Translation:HumansAnimals
  173. Nardell EA, Rubin EJ. Once upon a time. . . improved intermittent therapy for tuberculosis--fact or fable? Am J Respir Crit Care Med. 2005 Dec 01; 172(11):1361-2. PMID: 16301300.
    Citations: 3     Fields:    Translation:Humans
  174. Xie Z, Siddiqi N, Rubin EJ. Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2005 Nov; 49(11):4778-80. PMID: 16251329.
    Citations: 49     Fields:    Translation:Cells
  175. Murry J, Sassetti CM, Moreira J, Lane J, Rubin EJ. A new site-specific integration system for mycobacteria. Tuberculosis (Edinb). 2005 Sep-Nov; 85(5-6):317-23. PMID: 16256438.
    Citations: 9     Fields:    Translation:Cells
  176. Bisaga A, Aharonovich E, Garawi F, Levin FR, Rubin E, Raby WN, Nunes EV. A randomized placebo-controlled trial of gabapentin for cocaine dependence. Drug Alcohol Depend. 2006 Feb 28; 81(3):267-74. PMID: 16169160.
    Citations: 30