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Eric Joseph Rubin, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI116142 (PYM, ALEXANDER S) Feb 25, 2015 - Jan 31, 2017
    NIH/NIAID
    Fate of M. tuberculosis Antibiotic Survivors
    Role: Co-Principal Investigator
  2. U19AI109755 (MURRAY, MEGAN B) Mar 1, 2014 - Feb 28, 2019
    NIH/NIAID
    Integrated discovery and development of innovative TB Diagnostics
    Role: Co-Principal Investigator
  3. U19AI107774 (RUBIN, ERIC J.) Jul 2, 2013 - Jun 30, 2018
    NIH/NIAID
    Decoding the roles of critical genes of unknown function in M. tuberculosis
    Role: Co-Principal Investigator
  4. P01AI095208 (SACCHETTINI, JAMES C) Sep 1, 2012 - Aug 31, 2016
    NIH/NIAID
    Structure-based Discovery of Critical Vulnerabilities of Micobacteria
    Role: Co-Principal Investigator
  5. R01AI097191 (DERBYSHIRE, KEITH M) May 15, 2012 - Apr 30, 2017
    NIH/NIAID
    A Community Mycobacterial Systems Resource
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Hoi LV, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P. Moving Toward Tuberculosis Elimination: Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection. Am J Respir Crit Care Med. 2018 Oct 18. PMID: 30335466.
    View in: PubMed
  2. Bedi G, Hao X, Van Dam NT, Cooper ZD, Rubin E, Vadhan NP, Marino L, Haney M. Social motivational processing and interpersonal function in aging cocaine smokers. Addict Biol. 2018 Oct 17. PMID: 30328665.
    View in: PubMed
  3. Baranowski C, Welsh MA, Sham LT, Eskandarian HA, Lim HC, Kieser KJ, Wagner JC, McKinney JD, Fantner GE, Ioerger TR, Walker S, Bernhardt TG, Rubin EJ, Rego EH. Maturing Mycobacterium smegmatis peptidoglycan requires non-canonical crosslinks to maintain shape. Elife. 2018 10 16; 7. PMID: 30324906.
    View in: PubMed
  4. Rubin EJ. Of MICs and Men. N Engl J Med. 2018 08 30; 379(9):882-883. PMID: 30157402.
    View in: PubMed
  5. Chaudhuri S, Li L, Zimmerman M, Chen Y, Chen YX, Toosky MN, Gardner M, Pan M, Li YY, Kawaji Q, Zhu JH, Su HW, Martinot AJ, Rubin EJ, Dartois VA, Javid B. Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation. Elife. 2018 08 28; 7. PMID: 30152756.
    View in: PubMed
  6. Crofts AA, Giovanetti SM, Rubin EJ, Poly FM, Gutiérrez RL, Talaat KR, Porter CK, Riddle MS, DeNearing B, Brubaker J, Maciel M, Alcala AN, Chakraborty S, Prouty MG, Savarino SJ, Davies BW, Trent MS. Enterotoxigenic E. coli virulence gene regulation in human infections. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):E8968-E8976. PMID: 30126994.
    View in: PubMed
  7. Rubin EJ. TB diagnosis from the Dark Ages to fluorescence. Nat Microbiol. 2018 Mar; 3(3):268-269. PMID: 29463926.
    View in: PubMed
  8. Wu KJ, Zhang J, Baranowski C, Leung V, Rego EH, Morita YS, Rubin EJ, Boutte CC. Characterization of Conserved and Novel Septal Factors in Mycobacterium smegmatis. J Bacteriol. 2018 03 15; 200(6). PMID: 29311277.
    View in: PubMed
  9. Rubin EJ, Fortune SM. Misunderstanding the goals of animal research. BMJ. 2018 02 21; 360:k759. PMID: 29467126.
    View in: PubMed
  10. Franchina FA, Mellors TR, Aliyeva M, Wagner J, Daphtary N, Lundblad LKA, Fortune SM, Rubin EJ, Hill JE. Towards the use of breath for detecting mycobacterial infection: a case study in a murine model. J Breath Res. 2018 Feb 07; 12(2):026008. PMID: 29219122.
    View in: PubMed
  11. Laencina L, Dubois V, Le Moigne V, Viljoen A, Majlessi L, Pritchard J, Bernut A, Piel L, Roux AL, Gaillard JL, Lombard B, Loew D, Rubin EJ, Brosch R, Kremer L, Herrmann JL, Girard-Misguich F. Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E1002-E1011. PMID: 29343644.
    View in: PubMed
  12. Guinn KM, Rubin EJ. Tuberculosis: Just the FAQs. MBio. 2017 12 19; 8(6). PMID: 29259086.
    View in: PubMed
  13. Lehmann J, Cheng TY, Aggarwal A, Park AS, Zeiler E, Raju RM, Akopian T, Kandror O, Sacchettini JC, Moody DB, Rubin EJ, Sieber SA. An Antibacterial ß-Lactone Kills Mycobacterium tuberculosis by Disrupting Mycolic Acid Biosynthesis. Angew Chem Int Ed Engl. 2018 Jan 02; 57(1):348-353. PMID: 29067779.
    View in: PubMed
  14. Baden LR, Rubin EJ, Morrissey S, Farrar JJ, Drazen JM. We Can Do Better - Improving Outcomes in the Midst of an Emergency. N Engl J Med. 2017 10 12; 377(15):1482-1484. PMID: 29020598.
    View in: PubMed
  15. Kim ES, Bruinooge SS, Roberts S, Ison G, Lin NU, Gore L, Uldrick TS, Lichtman SM, Roach N, Beaver JA, Sridhara R, Hesketh PJ, Denicoff AM, Garrett-Mayer E, Rubin E, Multani P, Prowell TM, Schenkel C, Kozak M, Allen J, Sigal E, Schilsky RL. Broadening Eligibility Criteria to Make Clinical Trials More Representative: American Society of Clinical Oncology and Friends of Cancer Research Joint Research Statement. J Clin Oncol. 2017 Nov 20; 35(33):3737-3744. PMID: 28968170.
    View in: PubMed
  16. Gore L, Ivy SP, Balis FM, Rubin E, Thornton K, Donoghue M, Roberts S, Bruinooge S, Ersek J, Goodman N, Schenkel C, Reaman G. Modernizing Clinical Trial Eligibility: Recommendations of the American Society of Clinical Oncology-Friends of Cancer Research Minimum Age Working Group. J Clin Oncol. 2017 Nov 20; 35(33):3781-3787. PMID: 28968169.
    View in: PubMed
  17. Yadon AN, Maharaj K, Adamson JH, Lai YP, Sacchettini JC, Ioerger TR, Rubin EJ, Pym AS. A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide. Nat Commun. 2017 09 19; 8(1):588. PMID: 28928454.
    View in: PubMed
  18. Yee M, Klinzing D, Wei JR, Gengenbacher M, Rubin EJ, Chien JY, Hsueh PR, Dick T. Draft Genome Sequence of Mycobacterium avium 11. Genome Announc. 2017 Aug 10; 5(32). PMID: 28798178.
    View in: PubMed
  19. Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC. Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell. 2017 Jul 13; 170(2):249-259.e25. PMID: 28669536.
    View in: PubMed
  20. Rubin EJ. Reviving a Drug for Tuberculosis? N Engl J Med. 2017 Jun 08; 376(23):2292-2294. PMID: 28591540.
    View in: PubMed
  21. Rego EH, Audette RE, Rubin EJ. Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity. Nature. 2017 06 01; 546(7656):153-157. PMID: 28569798.
    View in: PubMed
  22. Yee M, Klinzing D, Wei JR, Gengenbacher M, Rubin EJ, Dick T. Draft Genome Sequence of Mycobacterium abscessus Bamboo. Genome Announc. 2017 May 18; 5(20). PMID: 28522728.
    View in: PubMed
  23. Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM. Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform. Nat Microbiol. 2017 Feb 06; 2:16274. PMID: 28165460.
    View in: PubMed
  24. DeJesus MA, Gerrick ER, Xu W, Park SW, Long JE, Boutte CC, Rubin EJ, Schnappinger D, Ehrt S, Fortune SM, Sassetti CM, Ioerger TR. Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis. MBio. 2017 01 17; 8(1). PMID: 28096490.
    View in: PubMed
  25. Baric RS, Crosson S, Damania B, Miller SI, Rubin EJ. Next-Generation High-Throughput Functional Annotation of Microbial Genomes. MBio. 2016 10 04; 7(5). PMID: 27703071.
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  26. Yamada HY, Kumar G, Zhang Y, Rubin E, Lightfoot S, Dai W, Rao CV. Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung. Oncogenesis. 2016 Aug 15; 5(8):e256. PMID: 27526110; PMCID: PMC5007830.
  27. Baranowski C, Rubin EJ. Could Killing Bacterial Subpopulations Hit Tuberculosis out of the Park? J Med Chem. 2016 07 14; 59(13):6025-6. PMID: 27322073.
    View in: PubMed
  28. Boutte CC, Baer CE, Papavinasasundaram K, Liu W, Chase MR, Meniche X, Fortune SM, Sassetti CM, Ioerger TR, Rubin EJ. A cytoplasmic peptidoglycan amidase homologue controls mycobacterial cell wall synthesis. Elife. 2016 06 15; 5. PMID: 27304077; PMCID: PMC4946905.
  29. Filippova EV, Kieser KJ, Luan CH, Wawrzak Z, Kiryukhina O, Rubin EJ, Anderson WF. Crystal structures of the transpeptidase domain of the Mycobacterium tuberculosis penicillin-binding protein PonA1 reveal potential mechanisms of antibiotic resistance. FEBS J. 2016 06; 283(12):2206-18. PMID: 27101811.
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  30. Marakalala MJ, Raju RM, Sharma K, Zhang YJ, Eugenin EA, Prideaux B, Daudelin IB, Chen PY, Booty MG, Kim JH, Eum SY, Via LE, Behar SM, Barry CE, Mann M, Dartois V, Rubin EJ. Inflammatory signaling in human tuberculosis granulomas is spatially organized. Nat Med. 2016 05; 22(5):531-8. PMID: 27043495.
    View in: PubMed
  31. Raju RM, Raju SM, Zhao Y, Rubin EJ. Leveraging Advances in Tuberculosis Diagnosis and Treatment to Address Nontuberculous Mycobacterial Disease. Emerg Infect Dis. 2016 Mar; 22(3):365-9. PMID: 26886068; PMCID: PMC4766907.
  32. Rubin EJ, Greene MF, Baden LR. Zika Virus and Microcephaly. N Engl J Med. 2016 Mar 10; 374(10):984-5. PMID: 26862812.
    View in: PubMed
  33. Martinot AJ, Farrow M, Bai L, Layre E, Cheng TY, Tsai JH, Iqbal J, Annand JW, Sullivan ZA, Hussain MM, Sacchettini J, Moody DB, Seeliger JC, Rubin EJ. Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis. PLoS Pathog. 2016 Jan; 12(1):e1005351. PMID: 26751071; PMCID: PMC4709180.
  34. Ivanova A, Anderson KM, Rosner GL, Rubin E. Comment. Stat Biopharm Res. 2015; 7(4):357-358. PMID: 30416674.
    View in: PubMed
  35. Kieser KJ, Baranowski C, Chao MC, Long JE, Sassetti CM, Waldor MK, Sacchettini JC, Ioerger TR, Rubin EJ. Peptidoglycan synthesis in Mycobacterium tuberculosis is organized into networks with varying drug susceptibility. Proc Natl Acad Sci U S A. 2015 Oct 20; 112(42):13087-92. PMID: 26438867; PMCID: PMC4620856.
  36. Dragset MS, Barczak AK, Kannan N, Mærk M, Flo TH, Valla S, Rubin EJ, Steigedal M. Benzoic Acid-Inducible Gene Expression in Mycobacteria. PLoS One. 2015; 10(9):e0134544. PMID: 26348349.
    View in: PubMed
  37. Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ. Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. PLoS Pathog. 2015 Jun; 11(6):e1005010. PMID: 26114871.
    View in: PubMed
  38. Moreira W, Ngan GJ, Low JL, Poulsen A, Chia BC, Ang MJ, Yap A, Fulwood J, Lakshmanan U, Lim J, Khoo AY, Flotow H, Hill J, Raju RM, Rubin EJ, Dick T. Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria. MBio. 2015 May 05; 6(3):e00253-15. PMID: 25944857; PMCID: PMC4436076.
  39. Foltin RW, Haney M, Rubin E, Reed SC, Vadhan N, Balter R, Evans SM. Development of translational preclinical models in substance abuse: Effects of cocaine administration on cocaine choice in humans and non-human primates. Pharmacol Biochem Behav. 2015 Jul; 134:12-21. PMID: 25933796.
    View in: PubMed
  40. Madigan CA, Martinot AJ, Wei JR, Madduri A, Cheng TY, Young DC, Layre E, Murry JP, Rubin EJ, Moody DB. Lipidomic analysis links mycobactin synthase K to iron uptake and virulence in M. tuberculosis. PLoS Pathog. 2015 Mar; 11(3):e1004792. PMID: 25815898; PMCID: PMC4376628.
  41. Akopian T, Kandror O, Tsu C, Lai JH, Wu W, Liu Y, Zhao P, Park A, Wolf L, Dick LR, Rubin EJ, Bachovchin W, Goldberg AL. Cleavage Specificity of Mycobacterium tuberculosis ClpP1P2 Protease and Identification of Novel Peptide Substrates and Boronate Inhibitors with Anti-bacterial Activity. J Biol Chem. 2015 Apr 24; 290(17):11008-20. PMID: 25759383.
    View in: PubMed
  42. Baer CE, Rubin EJ, Sassetti CM. New insights into TB physiology suggest untapped therapeutic opportunities. Immunol Rev. 2015 Mar; 264(1):327-43. PMID: 25703570; PMCID: PMC4339208.
  43. Landeta C, Blazyk JL, Hatahet F, Meehan BM, Eser M, Myrick A, Bronstain L, Minami S, Arnold H, Ke N, Rubin EJ, Furie BC, Furie B, Beckwith J, Dutton R, Boyd D. Compounds targeting disulfide bond forming enzyme DsbB of Gram-negative bacteria. Nat Chem Biol. 2015 Apr; 11(4):292-8. PMID: 25686372; PMCID: PMC4366281.
  44. Ingelfinger JR, Rubin EJ. The HIV-positive transplant donor--change born of necessity. N Engl J Med. 2015 Feb 12; 372(7):663-5. PMID: 25671260.
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  45. Dragset MS, Poce G, Alfonso S, Padilla-Benavides T, Ioerger TR, Kaneko T, Sacchettini JC, Biava M, Parish T, Argüello JM, Steigedal M, Rubin EJ. A novel antimycobacterial compound acts as an intracellular iron chelator. Antimicrob Agents Chemother. 2015 Apr; 59(4):2256-64. PMID: 25645825; PMCID: PMC4356758.
  46. Rodionova IA, Zuccola HJ, Sorci L, Aleshin AE, Kazanov MD, Ma CT, Sergienko E, Rubin EJ, Locher CP, Osterman AL. Mycobacterial nicotinate mononucleotide adenylyltransferase: structure, mechanism, and implications for drug discovery. J Biol Chem. 2015 Mar 20; 290(12):7693-706. PMID: 25631047; PMCID: PMC4367272.
  47. Rubin EJ, Herrera CM, Crofts AA, Trent MS. PmrD is required for modifications to escherichia coli endotoxin that promote antimicrobial resistance. Antimicrob Agents Chemother. 2015 Apr; 59(4):2051-61. PMID: 25605366; PMCID: PMC4356761.
  48. Drazen JM, Campion EW, Rubin EJ, Morrissey S, Baden LR. Ebola in West Africa at one year--from ignorance to fear to roadblocks. N Engl J Med. 2015 Feb 05; 372(6):563-4. PMID: 25539445.
    View in: PubMed
  49. Rubin EJ, Baden LR. Out of Africa--caring for patients with Ebola. N Engl J Med. 2014 Dec 18; 371(25):2430-2. PMID: 25390461.
    View in: PubMed
  50. Pritchard JR, Chao MC, Abel S, Davis BM, Baranowski C, Zhang YJ, Rubin EJ, Waldor MK. ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing. PLoS Genet. 2014 Nov; 10(11):e1004782. PMID: 25375795; PMCID: PMC4222735.
  51. Drazen JM, Kanapathipillai R, Campion EW, Rubin EJ, Hammer SM, Morrissey S, Baden LR. Ebola and quarantine. N Engl J Med. 2014 Nov 20; 371(21):2029-30. PMID: 25347231.
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  52. Baden LR, Kanapathipillai R, Campion EW, Morrissey S, Rubin EJ, Drazen JM. Ebola--an ongoing crisis. N Engl J Med. 2014 Oct 09; 371(15):1458-9. PMID: 25237780.
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  53. Seymour JF, Kim DW, Rubin E, Haregewoin A, Clark J, Watson P, Hughes T, Dufva I, Jimenez JL, Mahon FX, Rousselot P, Cortes J, Martinelli G, Papayannidis C, Nagler A, Giles FJ. A phase 2 study of MK-0457 in patients with BCR-ABL T315I mutant chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia. Blood Cancer J. 2014 Aug 15; 4:e238. PMID: 25127392; PMCID: PMC4219463.
  54. Santa Maria JP, Sadaka A, Moussa SH, Brown S, Zhang YJ, Rubin EJ, Gilmore MS, Walker S. Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12510-5. PMID: 25104751.
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  55. Trauner A, Sassetti CM, Rubin EJ. Genetic Strategies for Identifying New Drug Targets. Microbiol Spectr. 2014 Aug; 2(4):MGM2-0030-2013. PMID: 26104208.
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  56. Mir M, Prisic S, Kang CM, Lun S, Guo H, Murry JP, Rubin EJ, Husson RN. Mycobacterial gene cuvA is required for optimal nutrient utilization and virulence. Infect Immun. 2014 Oct; 82(10):4104-17. PMID: 25047842; PMCID: PMC4187881.
  57. Kieser KJ, Rubin EJ. How sisters grow apart: mycobacterial growth and division. Nat Rev Microbiol. 2014 Aug; 12(8):550-62. PMID: 24998739.
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  58. Mavrici D, Marakalala MJ, Holton JM, Prigozhin DM, Gee CL, Zhang YJ, Rubin EJ, Alber T. Mycobacterium tuberculosis FtsX extracellular domain activates the peptidoglycan hydrolase, RipC. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):8037-42. PMID: 24843173; PMCID: PMC4050617.
  59. Ngubane NA, Gresh L, Pym A, Rubin EJ, Khati M. Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX. Biochem Biophys Res Commun. 2014 Jun 20; 449(1):114-9. PMID: 24813997.
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  60. Siegrist MS, Steigedal M, Ahmad R, Mehra A, Dragset MS, Schuster BM, Philips JA, Carr SA, Rubin EJ. Mycobacterial Esx-3 requires multiple components for iron acquisition. MBio. 2014 May 06; 5(3):e01073-14. PMID: 24803520; PMCID: PMC4010830.
  61. Raju RM, Jedrychowski MP, Wei JR, Pinkham JT, Park AS, O'Brien K, Rehren G, Schnappinger D, Gygi SP, Rubin EJ. Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis. PLoS Pathog. 2014 Mar; 10(3):e1003994. PMID: 24603869; PMCID: PMC3946367.
  62. Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 2014 Feb; 10(2):e1003946. PMID: 24586159.
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  63. Rodionova IA, Schuster BM, Guinn KM, Sorci L, Scott DA, Li X, Kheterpal I, Shoen C, Cynamon M, Locher C, Rubin EJ, Osterman AL. Metabolic and bactericidal effects of targeted suppression of NadD and NadE enzymes in mycobacteria. MBio. 2014 Feb 18; 5(1). PMID: 24549842; PMCID: PMC3944813.
  64. Layre E, Lee HJ, Young DC, Martinot AJ, Buter J, Minnaard AJ, Annand JW, Fortune SM, Snider BB, Matsunaga I, Rubin EJ, Alber T, Moody DB. Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):2978-83. PMID: 24516143; PMCID: PMC3939896.
  65. Rubin EJ. Troubles with tuberculosis prevention. N Engl J Med. 2014 Jan 23; 370(4):375-6. PMID: 24450896.
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  66. Rubin EJ, O'Brien JP, Ivanov PL, Brodbelt JS, Trent MS. Identification of a broad family of lipid A late acyltransferases with non-canonical substrate specificity. Mol Microbiol. 2014 Mar; 91(5):887-99. PMID: 24372821; PMCID: PMC3947442.
  67. Javid B, Sorrentino F, Toosky M, Zheng W, Pinkham JT, Jain N, Pan M, Deighan P, Rubin EJ. Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1132-7. PMID: 24395793; PMCID: PMC3903211.
  68. Zhang YJ, Reddy MC, Ioerger TR, Rothchild AC, Dartois V, Schuster BM, Trauner A, Wallis D, Galaviz S, Huttenhower C, Sacchettini JC, Behar SM, Rubin EJ. Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell. 2013 Dec 05; 155(6):1296-308. PMID: 24315099; PMCID: PMC3902092.
  69. Ngubane NA, Gresh L, Ioerger TR, Sacchettini JC, Zhang YJ, Rubin EJ, Pym A, Khati M. High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria. PLoS One. 2013; 8(11):e77844. PMID: 24265677; PMCID: PMC3827053.
  70. Jean-Francois FL, Dai J, Yu L, Myrick A, Rubin E, Fajer PG, Song L, Zhou HX, Cross TA. Binding of MgtR, a Salmonella transmembrane regulatory peptide, to MgtC, a Mycobacterium tuberculosis virulence factor: a structural study. J Mol Biol. 2014 Jan 23; 426(2):436-46. PMID: 24140750; PMCID: PMC3947350.
  71. Zheng J, Rubin EJ, Bifani P, Mathys V, Lim V, Au M, Jang J, Nam J, Dick T, Walker JR, Pethe K, Camacho LR. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013 Oct 4; 288(40):28951. PMID: 24098010.
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  72. Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE, Sherman DR, Parish T, Sacchettini JC. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One. 2013; 8(9):e75245. PMID: 24086479.
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  73. Farhat MR, Shapiro BJ, Kieser KJ, Sultana R, Jacobson KR, Victor TC, Warren RM, Streicher EM, Calver A, Sloutsky A, Kaur D, Posey JE, Plikaytis B, Oggioni MR, Gardy JL, Johnston JC, Rodrigues M, Tang PK, Kato-Maeda M, Borowsky ML, Muddukrishna B, Kreiswirth BN, Kurepina N, Galagan J, Gagneux S, Birren B, Rubin EJ, Lander ES, Sabeti PC, Murray M. Genomic analysis identifies targets of convergent positive selection in drug-resistant Mycobacterium tuberculosis. Nat Genet. 2013 Oct; 45(10):1183-9. PMID: 23995135.
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  74. Chao MC, Pritchard JR, Zhang YJ, Rubin EJ, Livny J, Davis BM, Waldor MK. High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data. Nucleic Acids Res. 2013 Oct; 41(19):9033-48. PMID: 23901011; PMCID: PMC3799429.
  75. Rubin EJ, Trent MS. Colonize, evade, flourish: how glyco-conjugates promote virulence of Helicobacter pylori. Gut Microbes. 2013 Nov-Dec; 4(6):439-53. PMID: 23859890; PMCID: PMC3928157.
  76. Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT. Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):11565-70. PMID: 23798446; PMCID: PMC3710825.
  77. Zheng J, Rubin EJ, Bifani P, Mathys V, Lim V, Au M, Jang J, Nam J, Dick T, Walker JR, Pethe K, Camacho LR. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013 Aug 09; 288(32):23447-56. PMID: 23779105.
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  78. Comer SD, Mogali S, Saccone PA, Askalsky P, Martinez D, Walker EA, Jones JD, Vosburg SK, Cooper ZD, Roux P, Sullivan MA, Manubay JM, Rubin E, Pines A, Berkower EL, Haney M, Foltin RW. Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers. Neuropsychopharmacology. 2013 Nov; 38(12):2427-38. PMID: 23736314; PMCID: PMC3799062.
  79. Zhang YJ, Rubin EJ. Feast or famine: the host-pathogen battle over amino acids. Cell Microbiol. 2013 Jul; 15(7):1079-87. PMID: 23521858.
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  80. Chao MC, Kieser KJ, Minami S, Mavrici D, Aldridge BB, Fortune SM, Alber T, Rubin EJ. Protein complexes and proteolytic activation of the cell wall hydrolase RipA regulate septal resolution in mycobacteria. PLoS Pathog. 2013 Feb; 9(2):e1003197. PMID: 23468634; PMCID: PMC3585148.
  81. Hickman HD, Reynoso GV, Ngudiankama BF, Rubin EJ, Magadán JG, Cush SS, Gibbs J, Molon B, Bronte V, Bennink JR, Yewdell JW. Anatomically restricted synergistic antiviral activities of innate and adaptive immune cells in the skin. Cell Host Microbe. 2013 Feb 13; 13(2):155-68. PMID: 23414756.
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  82. DeJesus MA, Zhang YJ, Sassetti CM, Rubin EJ, Sacchettini JC, Ioerger TR. Bayesian analysis of gene essentiality based on sequencing of transposon insertion libraries. Bioinformatics. 2013 Mar 15; 29(6):695-703. PMID: 23361328; PMCID: PMC3597147.
  83. De Leon J, Jiang G, Ma Y, Rubin E, Fortune S, Sun J. Mycobacterium tuberculosis ESAT-6 exhibits a unique membrane-interacting activity that is not found in its ortholog from non-pathogenic Mycobacterium smegmatis. J Biol Chem. 2012 Dec 28; 287(53):44184-91. PMID: 23150662; PMCID: PMC3531734.
  84. Raju RM, Goldberg AL, Rubin EJ. Bacterial proteolytic complexes as therapeutic targets. Nat Rev Drug Discov. 2012 Oct; 11(10):777-89. PMID: 23023677.
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  85. Zhang YJ, Ioerger TR, Huttenhower C, Long JE, Sassetti CM, Sacchettini JC, Rubin EJ. Global assessment of genomic regions required for growth in Mycobacterium tuberculosis. PLoS Pathog. 2012 Sep; 8(9):e1002946. PMID: 23028335; PMCID: PMC3460630.
  86. Robertson BD, Altmann D, Barry C, Bishai B, Cole S, Dick T, Duncan K, Dye C, Ehrt S, Esmail H, Flynn J, Hafner R, Handley G, Hanekom W, van Helden P, Kaplan G, Kaufmann SH, Kim P, Lienhardt C, Mizrahi V, Rubin E, Schnappinger D, Sherman D, Thole J, Vandal O, Walzl G, Warner D, Wilkinson R, Young D. Detection and treatment of subclinical tuberculosis. Tuberculosis (Edinb). 2012 Nov; 92(6):447-52. PMID: 22819716.
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  87. Raju RM, Unnikrishnan M, Rubin DH, Krishnamoorthy V, Kandror O, Akopian TN, Goldberg AL, Rubin EJ. Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. PLoS Pathog. 2012 Feb; 8(2):e1002511. PMID: 22359499; PMCID: PMC3280978.
  88. Akopian T, Kandror O, Raju RM, Unnikrishnan M, Rubin EJ, Goldberg AL. The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring. EMBO J. 2012 Mar 21; 31(6):1529-41. PMID: 22286948; PMCID: PMC3321190.
  89. Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T. A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria. Sci Signal. 2012 Jan 24; 5(208):ra7. PMID: 22275220; PMCID: PMC3664666.
  90. Madigan CA, Cheng TY, Layre E, Young DC, McConnell MJ, Debono CA, Murry JP, Wei JR, Barry CE, Rodriguez GM, Matsunaga I, Rubin EJ, Moody DB. Lipidomic discovery of deoxysiderophores reveals a revised mycobactin biosynthesis pathway in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2012 Jan 24; 109(4):1257-62. PMID: 22232695; PMCID: PMC3268331.
  91. Cheng Y, Zhang Y, Zhang L, Ren X, Huber-Keener KJ, Liu X, Zhou L, Liao J, Keihack H, Yan L, Rubin E, Yang JM. MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Mol Cancer Ther. 2012 Jan; 11(1):154-64. PMID: 22057914; PMCID: PMC3302182.
  92. Hickman HD, Li L, Reynoso GV, Rubin EJ, Skon CN, Mays JW, Gibbs J, Schwartz O, Bennink JR, Yewdell JW. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med. 2011 Nov 21; 208(12):2511-24. PMID: 22042976; PMCID: PMC3256957.
  93. La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, Botta M, De Logu A, Rubin EJ, De Rossi E. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob Agents Chemother. 2012 Jan; 56(1):324-31. PMID: 22024828; PMCID: PMC3256021.
  94. Keren I, Minami S, Rubin E, Lewis K. Characterization and transcriptome analysis of Mycobacterium tuberculosis persisters. MBio. 2011; 2(3):e00100-11. PMID: 21673191; PMCID: PMC3119538.
  95. Horsburgh CR, Rubin EJ. Clinical practice. Latent tuberculosis infection in the United States. N Engl J Med. 2011 Apr 14; 364(15):1441-8. PMID: 21488766.
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  96. Haney M, Rubin E, Foltin RW. Aripiprazole maintenance increases smoked cocaine self-administration in humans. Psychopharmacology (Berl). 2011 Aug; 216(3):379-87. PMID: 21373790; PMCID: PMC3133869.
  97. Wei JR, Krishnamoorthy V, Murphy K, Kim JH, Schnappinger D, Alber T, Sassetti CM, Rhee KY, Rubin EJ. Depletion of antibiotic targets has widely varying effects on growth. Proc Natl Acad Sci U S A. 2011 Mar 08; 108(10):4176-81. PMID: 21368134; PMCID: PMC3053961.
  98. Cheng Y, Ren X, Zhang Y, Patel R, Sharma A, Wu H, Robertson GP, Yan L, Rubin E, Yang JM. eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer Res. 2011 Apr 01; 71(7):2654-63. PMID: 21307130; PMCID: PMC3210447.
  99. Reed SC, Evans SM, Bedi G, Rubin E, Foltin RW. The effects of oral micronized progesterone on smoked cocaine self-administration in women. Horm Behav. 2011 Feb; 59(2):227-35. PMID: 21192940; PMCID: PMC3040275.
  100. Kim JH, Wei JR, Wallach JB, Robbins RS, Rubin EJ, Schnappinger D. Protein inactivation in mycobacteria by controlled proteolysis and its application to deplete the beta subunit of RNA polymerase. Nucleic Acids Res. 2011 Mar; 39(6):2210-20. PMID: 21075796; PMCID: PMC3064785.
  101. Fortune SM, Rubin EJ. Host transcription in active and latent tuberculosis. Genome Biol. 2010; 11(9):135. PMID: 20920149; PMCID: PMC2965379.
  102. Freundlich JS, Lalgondar M, Wei JR, Swanson S, Sorensen EJ, Rubin EJ, Sacchettini JC. The abyssomicin C family as in vitro inhibitors of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2010 Sep; 90(5):298-300. PMID: 20739223; PMCID: PMC3213896.
  103. Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 2010 Aug 10; 49(31):6746-60. PMID: 20565114; PMCID: PMC3503319.
  104. Hett EC, Chao MC, Rubin EJ. Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria. PLoS Pathog. 2010 Jul 29; 6(7):e1001020. PMID: 20686708; PMCID: PMC2912383.
  105. Sassetti CM, Rubin EJ. Relics of selection in the mycobacterial genome. Nat Genet. 2010 Jun; 42(6):476-8. PMID: 20502489; PMCID: PMC4043303.
  106. Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC. Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. J Bacteriol. 2010 Jul; 192(14):3645-53. PMID: 20472797; PMCID: PMC2897344.
  107. Chao MC, Rubin EJ. Letting sleeping dos lie: does dormancy play a role in tuberculosis? Annu Rev Microbiol. 2010; 64:293-311. PMID: 20825351.
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  108. Dutton RJ, Wayman A, Wei JR, Rubin EJ, Beckwith J, Boyd D. Inhibition of bacterial disulfide bond formation by the anticoagulant warfarin. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):297-301. PMID: 20018758; PMCID: PMC2806739.
  109. Bitter W, Houben EN, Bottai D, Brodin P, Brown EJ, Cox JS, Derbyshire K, Fortune SM, Gao LY, Liu J, Gey van Pittius NC, Pym AS, Rubin EJ, Sherman DR, Cole ST, Brosch R. Systematic genetic nomenclature for type VII secretion systems. PLoS Pathog. 2009 Oct; 5(10):e1000507. PMID: 19876390; PMCID: PMC2763215.
  110. Siegrist MS, Unnikrishnan M, McConnell MJ, Borowsky M, Cheng TY, Siddiqi N, Fortune SM, Moody DB, Rubin EJ. Mycobacterial Esx-3 is required for mycobactin-mediated iron acquisition. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18792-7. PMID: 19846780; PMCID: PMC2774023.
  111. Murry JP, Pandey AK, Sassetti CM, Rubin EJ. Phthiocerol dimycocerosate transport is required for resisting interferon-gamma-independent immunity. J Infect Dis. 2009 Sep 01; 200(5):774-82. PMID: 19622047; PMCID: PMC3677186.
  112. Ranjbar S, Boshoff HI, Mulder A, Siddiqi N, Rubin EJ, Goldfeld AE. HIV-1 replication is differentially regulated by distinct clinical strains of Mycobacterium tuberculosis. PLoS One. 2009 Jul 01; 4(7):e6116. PMID: 19568431; PMCID: PMC2699470.
  113. Rubin EJ. The granuloma in tuberculosis--friend or foe? N Engl J Med. 2009 Jun 04; 360(23):2471-3. PMID: 19494225.
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  114. Reed SC, Haney M, Evans SM, Vadhan NP, Rubin E, Foltin RW. Cardiovascular and subjective effects of repeated smoked cocaine administration in experienced cocaine users. Drug Alcohol Depend. 2009 Jun 01; 102(1-3):102-7. PMID: 19303723; PMCID: PMC2679224.
  115. Siegrist MS, Rubin EJ. Phage transposon mutagenesis. Methods Mol Biol. 2009; 465:311-23. PMID: 20560067.
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  116. Pandey AK, Raman S, Proff R, Joshi S, Kang CM, Rubin EJ, Husson RN, Sassetti CM. Nitrile-inducible gene expression in mycobacteria. Tuberculosis (Edinb). 2009 Jan; 89(1):12-6. PMID: 18801704; PMCID: PMC2845969.
  117. Wei JR, Rubin EJ. The many roads to essential genes. Tuberculosis (Edinb). 2008 Aug; 88 Suppl 1:S19-24. PMID: 18762149.
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  118. Hett EC, Rubin EJ. Bacterial growth and cell division: a mycobacterial perspective. Microbiol Mol Biol Rev. 2008 Mar; 72(1):126-56, table of contents. PMID: 18322037; PMCID: PMC2268284.
  119. Hett EC, Chao MC, Deng LL, Rubin EJ. A mycobacterial enzyme essential for cell division synergizes with resuscitation-promoting factor. PLoS Pathog. 2008 Feb 29; 4(2):e1000001. PMID: 18463693; PMCID: PMC2262848.
  120. Philips JA, Porto MC, Wang H, Rubin EJ, Perrimon N. ESCRT factors restrict mycobacterial growth. Proc Natl Acad Sci U S A. 2008 Feb 26; 105(8):3070-5. PMID: 18287038; PMCID: PMC2268586.
  121. Rengarajan J, Murphy E, Park A, Krone CL, Hett EC, Bloom BR, Glimcher LH, Rubin EJ. Mycobacterium tuberculosis Rv2224c modulates innate immune responses. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):264-9. PMID: 18172199; PMCID: PMC2224198.
  122. Murry JP, Sassetti CM, Lane JM, Xie Z, Rubin EJ. Transposon site hybridization in Mycobacterium tuberculosis. Methods Mol Biol. 2008; 416:45-59. PMID: 18392960.
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  123. Sacchettini JC, Rubin EJ, Freundlich JS. Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis. Nat Rev Microbiol. 2008 Jan; 6(1):41-52. PMID: 18079742.
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  124. Zolotarev AS, Unnikrishnan M, Shmukler BE, Clark JS, Vandorpe DH, Grigorieff N, Rubin EJ, Alper SL. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66. PMID: 18255326; PMCID: PMC2712756.
  125. Farrow MF, Rubin EJ. Function of a mycobacterial major facilitator superfamily pump requires a membrane-associated lipoprotein. J Bacteriol. 2008 Mar; 190(5):1783-91. PMID: 18156250; PMCID: PMC2258667.
  126. Hett EC, Chao MC, Steyn AJ, Fortune SM, Deng LL, Rubin EJ. A partner for the resuscitation-promoting factors of Mycobacterium tuberculosis. Mol Microbiol. 2007 Nov; 66(3):658-68. PMID: 17919286.
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  127. Fortune SM, Rubin EJ. The complex relationship between mycobacteria and macrophages: it's not all bliss. Cell Host Microbe. 2007 Jul 12; 2(1):5-6. PMID: 18005712.
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  128. Levin FR, Bisaga A, Raby W, Aharonovich E, Rubin E, Mariani J, Brooks DJ, Garawi F, Nunes EV. Effects of major depressive disorder and attention-deficit/hyperactivity disorder on the outcome of treatment for cocaine dependence. J Subst Abuse Treat. 2008 Jan; 34(1):80-9. PMID: 17574796; PMCID: PMC2254518.
  129. Hart CL, Haney M, Vosburg SK, Rubin E, Foltin RW. Smoked cocaine self-administration is decreased by modafinil. Neuropsychopharmacology. 2008 Mar; 33(4):761-8. PMID: 17568397.
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  130. Charity JC, Costante-Hamm MM, Balon EL, Boyd DH, Rubin EJ, Dove SL. Twin RNA polymerase-associated proteins control virulence gene expression in Francisella tularensis. PLoS Pathog. 2007 Jun; 3(6):e84. PMID: 17571921; PMCID: PMC1891329.
  131. Sassetti CM, Rubin EJ. The open book of infectious diseases. Nat Med. 2007 Mar; 13(3):279-80. PMID: 17342136.
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  132. Sebastian S, Dillon ST, Lynch JG, Blalock LT, Balon E, Lee KT, Comstock LE, Conlan JW, Rubin EJ, Tzianabos AO, Kasper DL. A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity. Infect Immun. 2007 May; 75(5):2591-602. PMID: 17296751; PMCID: PMC1865767.
  133. Hart CL, Haney M, Collins ED, Rubin E, Foltin RW. Smoked cocaine self-administration by humans is not reduced by large gabapentin maintenance doses. Drug Alcohol Depend. 2007 Jan 12; 86(2-3):274-7. PMID: 16879931.
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  134. Joshi SM, Pandey AK, Capite N, Fortune SM, Rubin EJ, Sassetti CM. Characterization of mycobacterial virulence genes through genetic interaction mapping. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11760-5. PMID: 16868085; PMCID: PMC1544243.
  135. Hung DT, Rubin EJ. Chemical biology and bacteria: not simply a matter of life or death. Curr Opin Chem Biol. 2006 Aug; 10(4):321-6. PMID: 16814591.
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  136. Diaz R, Siddiqi N, Rubin EJ. Detecting genetic variability among different Mycobacterium tuberculosis strains using DNA microarrays technology. Tuberculosis (Edinb). 2006 May-Jul; 86(3-4):314-8. PMID: 16644284.
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  137. Lane JM, Rubin EJ. Scaling down: a PCR-based method to efficiently screen for desired knockouts in a high density Mycobacterium tuberculosis picked mutant library. Tuberculosis (Edinb). 2006 May-Jul; 86(3-4):310-3. PMID: 16527544.
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  138. Fortune SM, Chase MR, Rubin EJ. Dividing oceans into pools: strategies for the global analysis of bacterial genes. Microbes Infect. 2006 May; 8(6):1631-6. PMID: 16697239.
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  139. Levin FR, Brooks DJ, Bisaga A, Raby W, Rubin E, Aharonovich E, Nunes EV. Severity of dependence and motivation for treatment: comparison of marijuana- and cocaine-dependent treatment seekers. J Addict Dis. 2006; 25(1):33-41. PMID: 16597571.
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  140. Nardell EA, Rubin EJ. Once upon a time. . . improved intermittent therapy for tuberculosis--fact or fable? Am J Respir Crit Care Med. 2005 Dec 01; 172(11):1361-2. PMID: 16301300.
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  141. Xie Z, Siddiqi N, Rubin EJ. Differential antibiotic susceptibilities of starved Mycobacterium tuberculosis isolates. Antimicrob Agents Chemother. 2005 Nov; 49(11):4778-80. PMID: 16251329; PMCID: PMC1280169.
  142. Murry J, Sassetti CM, Moreira J, Lane J, Rubin EJ. A new site-specific integration system for mycobacteria. Tuberculosis (Edinb). 2005 Sep-Nov; 85(5-6):317-23. PMID: 16256438.
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  143. Bisaga A, Aharonovich E, Garawi F, Levin FR, Rubin E, Raby WN, Nunes EV. A randomized placebo-controlled trial of gabapentin for cocaine dependence. Drug Alcohol Depend. 2006 Feb 28; 81(3):267-74. PMID: 16169160.
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  144. Murry JP, Rubin EJ. New genetic approaches shed light on TB virulence. Trends Microbiol. 2005 Aug; 13(8):366-72. PMID: 15982889.
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  145. Fortune SM, Jaeger A, Sarracino DA, Chase MR, Sassetti CM, Sherman DR, Bloom BR, Rubin EJ. Mutually dependent secretion of proteins required for mycobacterial virulence. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10676-81. PMID: 16030141; PMCID: PMC1176248.
  146. Philips JA, Rubin EJ, Perrimon N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science. 2005 Aug 19; 309(5738):1251-3. PMID: 16020694.
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  147. Agaisse H, Burrack LS, Philips JA, Rubin EJ, Perrimon N, Higgins DE. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science. 2005 Aug 19; 309(5738):1248-51. PMID: 16020693.
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  148. Kaufmann SH, Cole ST, Mizrahi V, Rubin E, Nathan C. Mycobacterium tuberculosis and the host response. J Exp Med. 2005 Jun 06; 201(11):1693-7. PMID: 15939785; PMCID: PMC2213264.
  149. Rengarajan J, Bloom BR, Rubin EJ. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8327-32. PMID: 15928073; PMCID: PMC1142121.
  150. Rubin EJ. Toward a new therapy for tuberculosis. N Engl J Med. 2005 Mar 03; 352(9):933-4. PMID: 15745987.
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  151. Rajendra R, Malegaonkar D, Pungaliya P, Marshall H, Rasheed Z, Brownell J, Liu LF, Lutzker S, Saleem A, Rubin EH. Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. J Biol Chem. 2004 Aug 27; 279(35):36440-4. PMID: 15247280.
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  152. Rengarajan J, Sassetti CM, Naroditskaya V, Sloutsky A, Bloom BR, Rubin EJ. The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol Microbiol. 2004 Jul; 53(1):275-82. PMID: 15225321.
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  153. Fortune SM, Solache A, Jaeger A, Hill PJ, Belisle JT, Bloom BR, Rubin EJ, Ernst JD. Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms. J Immunol. 2004 May 15; 172(10):6272-80. PMID: 15128816.
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  154. Sassetti CM, Rubin EJ. Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12989-94. PMID: 14569030; PMCID: PMC240732.
  155. Sampson SL, Rengarajan J, Rubin EJ. Bacterial genomics and vaccine design. Expert Rev Vaccines. 2003 Jun; 2(3):437-45. PMID: 12903808.
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  156. Sassetti CM, Boyd DH, Rubin EJ. Genes required for mycobacterial growth defined by high density mutagenesis. Mol Microbiol. 2003 Apr; 48(1):77-84. PMID: 12657046.
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  157. Eichbaum Q, Rubin EJ. Tuberculosis. Advances in laboratory diagnosis and drug susceptibility testing. Am J Clin Pathol. 2002 Dec; 118 Suppl:S3-17. PMID: 14569809.
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  158. Chiang SL, Rubin EJ. Construction of a mariner-based transposon for epitope-tagging and genomic targeting. Gene. 2002 Aug 21; 296(1-2):179-85. PMID: 12383515.
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  159. Sassetti C, Rubin EJ. Genomic analyses of microbial virulence. Curr Opin Microbiol. 2002 Feb; 5(1):27-32. PMID: 11834365.
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  160. Akerley BJ, Rubin EJ, Novick VL, Amaya K, Judson N, Mekalanos JJ. A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):966-71. PMID: 11805338; PMCID: PMC117414.
  161. Sassetti CM, Boyd DH, Rubin EJ. Comprehensive identification of conditionally essential genes in mycobacteria. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12712-7. PMID: 11606763; PMCID: PMC60119.
  162. Rubin E, Lithwick G, Levy AA. Structure and evolution of the hAT transposon superfamily. Genetics. 2001 Jul; 158(3):949-57. PMID: 11454746; PMCID: PMC1461711.
  163. Lampe DJ, Akerley BJ, Rubin EJ, Mekalanos JJ, Robertson HM. Hyperactive transposase mutants of the Himar1 mariner transposon. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11428-33. PMID: 10500193; PMCID: PMC18050.
  164. Bailly C, Carrasco C, Hamy F, Vezin H, Prudhomme M, Saleem A, Rubin E. The camptothecin-resistant topoisomerase I mutant F361S is cross-resistant to antitumor rebeccamycin derivatives. A model for topoisomerase I inhibition by indolocarbazoles. Biochemistry. 1999 Jul 06; 38(27):8605-11. PMID: 10393535.
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  165. Rubin EJ, Akerley BJ, Novik VN, Lampe DJ, Husson RN, Mekalanos JJ. In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1645-50. PMID: 9990078; PMCID: PMC15546.
  166. Poplin E, Roberts J, Tombs M, Grant S, Rubin E. Leucovorin, 5-fluorouracil, and gemcitabine: a phase I study. Invest New Drugs. 1999; 17(1):57-62. PMID: 10555123.
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  167. Akerley BJ, Rubin EJ, Camilli A, Lampe DJ, Robertson HM, Mekalanos JJ. Systematic identification of essential genes by in vitro mariner mutagenesis. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8927-32. PMID: 9671781; PMCID: PMC21179.
  168. Rubin EJ, Lin W, Mekalanos JJ, Waldor MK. Replication and integration of a Vibrio cholerae cryptic plasmid linked to the CTX prophage. Mol Microbiol. 1998 Jun; 28(6):1247-54. PMID: 9680213.
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  169. Wilhide CC, Jin Y, Guo Q, Li L, Li SX, Rubin E, Bray PF. The human integrin beta3 gene is 63 kb and contains a 5'-UTR sequence regulating expression. Blood. 1997 Nov 15; 90(10):3951-61. PMID: 9354663.
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  170. Mekalanos JJ, Rubin EJ, Waldor MK. Cholera: molecular basis for emergence and pathogenesis. FEMS Immunol Med Microbiol. 1997 Aug; 18(4):241-8. PMID: 9348159.
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  171. Waldor MK, Rubin EJ, Pearson GD, Kimsey H, Mekalanos JJ. Regulation, replication, and integration functions of the Vibrio cholerae CTXphi are encoded by region RS2. Mol Microbiol. 1997 Jun; 24(5):917-26. PMID: 9220000.
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  172. Berthou L, Duverger N, Emmanuel F, Langouët S, Auwerx J, Guillouzo A, Fruchart JC, Rubin E, Denèfle P, Staels B, Branellec D. Opposite regulation of human versus mouse apolipoprotein A-I by fibrates in human apolipoprotein A-I transgenic mice. J Clin Invest. 1996 Jun 01; 97(11):2408-16. PMID: 8647932; PMCID: PMC507325.
  173. Saleem A, Yuan ZM, Taneja N, Rubin E, Kufe DW, Kharbanda SM. Activation of serine/threonine protein kinases and early growth response 1 gene expression by tumor necrosis factor in human myeloid leukemia cells. J Immunol. 1995 Apr 15; 154(8):4150-6. PMID: 7706752.
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  174. Dillon ST, Rubin EJ, Yakubovich M, Pothoulakis C, LaMont JT, Feig LA, Gilbert RJ. Involvement of Ras-related Rho proteins in the mechanisms of action of Clostridium difficile toxin A and toxin B. Infect Immun. 1995 Apr; 63(4):1421-6. PMID: 7890404; PMCID: PMC173169.
  175. Rubin E, Wood V, Bharti A, Trites D, Lynch C, Hurwitz S, Bartel S, Levy S, Rosowsky A, Toppmeyer D, et al. A phase I and pharmacokinetic study of a new camptothecin derivative, 9-aminocamptothecin. Clin Cancer Res. 1995 Mar; 1(3):269-76. PMID: 9815982.
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  176. Commons ML, Lee P, Gutheil TG, Rubin E, Goldman M, Appelbaum PS. Moral state of reasoning and the misperceived "duty" to report past crimes (misprision). Int J Law Psychiatry. 1995; 18(4):415-24. PMID: 8557430.
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  177. Kharbanda S, Yuan ZM, Rubin E, Weichselbaum R, Kufe D. Activation of Src-like p56/p53lyn tyrosine kinase by ionizing radiation. J Biol Chem. 1994 Aug 12; 269(32):20739-43. PMID: 8051175.
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  178. Rubin E, Pantazis P, Bharti A, Toppmeyer D, Giovanella B, Kufe D. Identification of a mutant human topoisomerase I with intact catalytic activity and resistance to 9-nitro-camptothecin. J Biol Chem. 1994 Jan 28; 269(4):2433-9. PMID: 8300570.
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  179. Hass R, Hirano M, Kharbanda S, Rubin E, Meinhardt G, Kufe D. Resistance to phorbol ester-induced differentiation of a U-937 myeloid leukemia cell variant with a signaling defect upstream to Raf-1 kinase. Cell Growth Differ. 1993 Aug; 4(8):657-63. PMID: 8398907.
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  180. Chauhan D, Kharbanda SM, Rubin E, Barut BA, Mohrbacher A, Kufe DW, Anderson KC. Regulation of c-jun gene expression in human T lymphocytes. Blood. 1993 Mar 15; 81(6):1540-8. PMID: 8453101.
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  181. Kharbanda S, Rubin E, Datta R, Hass R, Sukhatme V, Kufe D. Transcriptional regulation of the early growth response 1 gene in human myeloid leukemia cells by okadaic acid. Cell Growth Differ. 1993 Jan; 4(1):17-23. PMID: 8381016.
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  182. Datta R, Rubin E, Sukhatme V, Qureshi S, Hallahan D, Weichselbaum RR, Kufe DW. Ionizing radiation activates transcription of the EGR1 gene via CArG elements. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10149-53. PMID: 1332031.
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  183. Datta R, Hallahan DE, Kharbanda SM, Rubin E, Sherman ML, Huberman E, Weichselbaum RR, Kufe DW. Involvement of reactive oxygen intermediates in the induction of c-jun gene transcription by ionizing radiation. Biochemistry. 1992 Sep 08; 31(35):8300-6. PMID: 1525167.
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  184. Kharbanda S, Datta R, Rubin E, Nakamura T, Hass R, Kufe D. Regulation of c-jun expression during induction of monocytic differentiation by okadaic acid. Cell Growth Differ. 1992 Jul; 3(7):391-9. PMID: 1419903.
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  185. Rubin E, Kharbanda S, Gunji H, Weichselbaum R, Kufe D. cis-Diamminedichloroplatinum(II) induces c-jun expression in human myeloid leukemia cells: potential involvement of a protein kinase C-dependent signaling pathway. Cancer Res. 1992 Feb 15; 52(4):878-82. PMID: 1737349.
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  186. Kharbanda S, Rubin E, Gunji H, Hinz H, Giovanella B, Pantazis P, Kufe D. Camptothecin and its derivatives induce expression of the c-jun protooncogene in human myeloid leukemia cells. Cancer Res. 1991 Dec 15; 51(24):6636-42. PMID: 1742737.
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  187. Rubin E, Kharbanda S, Gunji H, Kufe D. Activation of the c-jun protooncogene in human myeloid leukemia cells treated with etoposide. Mol Pharmacol. 1991 Jun; 39(6):697-701. PMID: 1904980.
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  188. LaBelle M, Austin MA, Rubin E, Krauss RM. Linkage analysis of low-density lipoprotein subclass phenotypes and the apolipoprotein B gene. Genet Epidemiol. 1991; 8(4):269-75. PMID: 1756949.
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  189. Chardin P, Boquet P, Madaule P, Popoff MR, Rubin EJ, Gill DM. The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J. 1989 Apr; 8(4):1087-92. PMID: 2501082; PMCID: PMC400918.
  190. Popoff MR, Rubin EJ, Gill DM, Boquet P. Actin-specific ADP-ribosyltransferase produced by a Clostridium difficile strain. Infect Immun. 1988 Sep; 56(9):2299-306. PMID: 3137166; PMCID: PMC259564.
  191. Rubin EJ, Gill DM, Boquet P, Popoff MR. Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum. Mol Cell Biol. 1988 Jan; 8(1):418-26. PMID: 3122025; PMCID: PMC363141.
  192. Perrine S, Kan YW, Greene MF, Rubin E, Cooper S, Cohen R, Roman C, Rudolph A, Faller DV. Inhibition of fetal globin gene switching in vivo in human and ovine fetuses. Prog Clin Biol Res. 1987; 251:545-54. PMID: 3432276.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.