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Zaza Mtine Ndhlovu, Ph.D.

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  1. R01AI145305 (NDHLOVU, ZAZA MTINE) Feb 7, 2019 - Jan 31, 2024
    NIH
    Epigenetic Control of CD8 T-Cell Differentiation in Human Lymph Nodes
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ng'uni T, Chasara C, Ndhlovu ZM. Major Scientific Hurdles in HIV Vaccine Development: Historical Perspective and Future Directions. Front Immunol. 2020; 11:590780. PMID: 33193428.
    Citations:    Fields:    
  2. Muema DM, Akilimali NA, Ndumnego OC, Rasehlo SS, Durgiah R, Ojwach DBA, Ismail N, Dong M, Moodley A, Dong KL, Ndhlovu ZM, Mabuka JM, Walker BD, Mann JK, Ndung'u T. Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection. BMC Med. 2020 03 25; 18(1):81. PMID: 32209092.
    Citations: 7     Fields:    Translation:Humans
  3. Kazer SW, Aicher TP, Muema DM, Carroll SL, Ordovas-Montanes J, Miao VN, Tu AA, Ziegler CGK, Nyquist SK, Wong EB, Ismail N, Dong M, Moodley A, Berger B, Love JC, Dong KL, Leslie A, Ndhlovu ZM, Ndung'u T, Walker BD, Shalek AK. Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection. Nat Med. 2020 04; 26(4):511-518. PMID: 32251406.
    Citations: 9     Fields:    Translation:HumansCells
  4. Ndhlovu ZM, Kazer SW, Nkosi T, Ogunshola F, Muema DM, Anmole G, Swann SA, Moodley A, Dong K, Reddy T, Brockman MA, Shalek AK, Ndung'u T, Walker BD. Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection. Sci Transl Med. 2019 05 22; 11(493). PMID: 31118290.
    Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
  5. Ogunshola F, Anmole G, Miller RL, Goering E, Nkosi T, Muema D, Mann J, Ismail N, Chopera D, Ndung'u T, Brockman MA, Ndhlovu ZM. Dual HLA B*42 and B*81-reactive T cell receptors recognize more diverse HIV-1 Gag escape variants. Nat Commun. 2018 11 27; 9(1):5023. PMID: 30479346.
    Citations: 1     Fields:    Translation:HumansCells
  6. Baiyegunhi O, Ndlovu B, Ogunshola F, Ismail N, Walker BD, Ndung'u T, Ndhlovu ZM. Frequencies of Circulating Th1-Biased T Follicular Helper Cells in Acute HIV-1 Infection Correlate with the Development of HIV-Specific Antibody Responses and Lower Set Point Viral Load. J Virol. 2018 08 01; 92(15). PMID: 29793949.
    Citations: 13     Fields:    Translation:HumansCells
  7. Dong KL, Moodley A, Kwon DS, Ghebremichael MS, Dong M, Ismail N, Ndhlovu ZM, Mabuka JM, Muema DM, Pretorius K, Lin N, Walker BD, Ndung'u T. Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study. Lancet HIV. 2018 01; 5(1):e35-e44. PMID: 28978417.
    Citations: 23     Fields:    Translation:HumansCells
  8. Laher F, Ranasinghe S, Porichis F, Mewalal N, Pretorius K, Ismail N, Buus S, Stryhn A, Carrington M, Walker BD, Ndung'u T, Ndhlovu ZM. HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells in Chronic Clade C HIV-1 Infection. J Virol. 2017 04 01; 91(7). PMID: 28077659.
    Citations: 5     Fields:    Translation:HumansCells
  9. Flerin NC, Chen H, Glover TD, Lamothe PA, Zheng JH, Fang JW, Ndhlovu ZM, Newell EW, Davis MM, Walker BD, Goldstein H. T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone. J Virol. 2017 03 15; 91(6). PMID: 28077649.
    Citations: 3     Fields:    Translation:HumansCells
  10. Koofhethile CK, Ndhlovu ZM, Thobakgale-Tshabalala C, Prado JG, Ismail N, Mncube Z, Mkhize L, van der Stok M, Yende N, Walker BD, Goulder PJR, Ndung'u T. CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles. J Virol. 2016 08 01; 90(15):6818-6831. PMID: 27194762.
    Citations: 10     Fields:    Translation:HumansCells
  11. Kløverpris HN, Kazer SW, Mjösberg J, Mabuka JM, Wellmann A, Ndhlovu Z, Yadon MC, Nhamoyebonde S, Muenchhoff M, Simoni Y, Andersson F, Kuhn W, Garrett N, Burgers WA, Kamya P, Pretorius K, Dong K, Moodley A, Newell EW, Kasprowicz V, Abdool Karim SS, Goulder P, Shalek AK, Walker BD, Ndung'u T, Leslie A. Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression. Immunity. 2016 Feb 16; 44(2):391-405. PMID: 26850658.
    Citations: 55     Fields:    Translation:HumansCells
  12. Ndhlovu ZM, Kamya P, Mewalal N, Kløverpris HN, Nkosi T, Pretorius K, Laher F, Ogunshola F, Chopera D, Shekhar K, Ghebremichael M, Ismail N, Moodley A, Malik A, Leslie A, Goulder PJ, Buus S, Chakraborty A, Dong K, Ndung'u T, Walker BD. Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. Immunity. 2015 Sep 15; 43(3):591-604. PMID: 26362266.
    Citations: 92     Fields:    Translation:HumansCells
  13. Ndhlovu ZM, Stampouloglou E, Cesa K, Mavrothalassitis O, Alvino DM, Li JZ, Wilton S, Karel D, Piechocka-Trocha A, Chen H, Pereyra F, Walker BD. The Breadth of Expandable Memory CD8+ T Cells Inversely Correlates with Residual Viral Loads in HIV Elite Controllers. J Virol. 2015 Nov; 89(21):10735-47. PMID: 26269189.
    Citations: 18     Fields:    Translation:HumansCells
  14. Radebe M, Gounder K, Mokgoro M, Ndhlovu ZM, Mncube Z, Mkhize L, van der Stok M, Jaggernath M, Walker BD, Ndung'u T. Broad and persistent Gag-specific CD8+ T-cell responses are associated with viral control but rarely drive viral escape during primary HIV-1 infection. AIDS. 2015 Jan 02; 29(1):23-33. PMID: 25387316.
    Citations: 24     Fields:    Translation:HumansCells
  15. Laher F, Ranasinghe S, Porichis F, Davis I, Mavrothalassitis O, Ismail N, Mewalal N, Mahungela S, Walker BD, Ndung'u T, Ndhlovu ZM. Differences in Immunodominant Patterns and HLA-DRB1 Restriction Characteristics in HIV-specific CD4 T-cell Responses between Clade B and C Infection. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A177. PMID: 25357496.
    Citations:    
  16. Byrne EH, Anahtar M, Doherty K, Olson G, Bowman B, Padavattan N, Ndhlovu Z, Ghebremichael M, Walker B, Ndung'u T, Dong K, Kwon DS. Injectable Contraceptive Use Correlates with Increased HIV Target Cells at the Cervix in Young South African Women. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A54-5. PMID: 25357881.
    Citations:    
  17. Ndhlovu Z, Kamya P, Mewalal N, Nkosi T, Ismail N, Moodley A, Dong K, Ndung'u T, Walker B. Massive Activation, Expansion and Subsequent Apoptosis of CD8 T-cells in Acute HIV Infection. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A74-5. PMID: 25357933.
    Citations:    
  18. Youngblood B, Noto A, Porichis F, Akondy RS, Ndhlovu ZM, Austin JW, Bordi R, Procopio FA, Miura T, Allen TM, Sidney J, Sette A, Walker BD, Ahmed R, Boss JM, Sékaly RP, Kaufmann DE. Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells. J Immunol. 2013 Jul 15; 191(2):540-4. PMID: 23772031.
    Citations: 68     Fields:    Translation:HumansCells
  19. Ndhlovu ZM, Chibnik LB, Proudfoot J, Vine S, McMullen A, Cesa K, Porichis F, Jones RB, Alvino DM, Hart MG, Stampouloglou E, Piechocka-Trocha A, Kadie C, Pereyra F, Heckerman D, De Jager PL, Walker BD, Kaufmann DE. High-dimensional immunomonitoring models of HIV-1-specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control. Blood. 2013 Jan 31; 121(5):801-11. PMID: 23233659.
    Citations: 28     Fields:    Translation:HumansCellsCTClinical Trials
  20. Chen H, Ndhlovu ZM, Liu D, Porter LC, Fang JW, Darko S, Brockman MA, Miura T, Brumme ZL, Schneidewind A, Piechocka-Trocha A, Cesa KT, Sela J, Cung TD, Toth I, Pereyra F, Yu XG, Douek DC, Kaufmann DE, Allen TM, Walker BD. TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection. Nat Immunol. 2012 Jun 10; 13(7):691-700. PMID: 22683743.
    Citations: 117     Fields:    Translation:HumansCells
  21. Ndhlovu ZM, Proudfoot J, Cesa K, Alvino DM, McMullen A, Vine S, Stampouloglou E, Piechocka-Trocha A, Walker BD, Pereyra F. Elite controllers with low to absent effector CD8+ T cell responses maintain highly functional, broadly directed central memory responses. J Virol. 2012 Jun; 86(12):6959-69. PMID: 22514340.
    Citations: 53     Fields:    Translation:HumansCells
  22. Ndhlovu ZM, Piechocka-Trocha A, Vine S, McMullen A, Koofhethile KC, Goulder PJ, Ndung'u T, Barouch DH, Walker BD. Mosaic HIV-1 Gag antigens can be processed and presented to human HIV-specific CD8+ T cells. J Immunol. 2011 Jun 15; 186(12):6914-24. PMID: 21576505.
    Citations: 18     Fields:    Translation:HumansCells
  23. Ndhlovu ZM, Oelke M, Schneck JP, Griffin DE. Dynamic regulation of functionally distinct virus-specific T cells. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3669-74. PMID: 20133680.
    Citations: 18     Fields:    Translation:HumansCells
  24. Nair N, Moss WJ, Scott S, Mugala N, Ndhlovu ZM, Lilo K, Ryon JJ, Monze M, Quinn TC, Cousens S, Cutts F, Griffin DE. HIV-1 infection in Zambian children impairs the development and avidity maturation of measles virus-specific immunoglobulin G after vaccination and infection. J Infect Dis. 2009 Oct 01; 200(7):1031-8. PMID: 19702505.
    Citations: 24     Fields:    Translation:HumansCellsPHPublic Health
  25. Ndhlovu ZM, Angenendt M, Heckel D, Schneck JP, Griffin DE, Oelke M. Development of an artificial-antigen-presenting-cell-based assay for the detection of low-frequency virus-specific CD8(+) T cells in whole blood, with application for measles virus. Clin Vaccine Immunol. 2009 Jul; 16(7):1066-73. PMID: 19494085.
    Citations: 6     Fields:    Translation:HumansCells
  26. Moss WJ, Scott S, Ndhlovu Z, Monze M, Cutts FT, Quinn TC, Griffin DE. Suppression of human immunodeficiency virus type 1 viral load during acute measles. Pediatr Infect Dis J. 2009 Jan; 28(1):63-5. PMID: 19057456.
    Citations: 4     Fields:    Translation:HumansCells
  27. Sutcliffe CG, Scott S, Mugala N, Ndhlovu Z, Monze M, Quinn TC, Cousens S, Griffin DE, Moss WJ. Survival from 9 months of age among HIV-infected and uninfected Zambian children prior to the availability of antiretroviral therapy. Clin Infect Dis. 2008 Sep 15; 47(6):837-44. PMID: 18680417.
    Citations: 15     Fields:    Translation:Humans
  28. Moss WJ, Scott S, Mugala N, Ndhlovu Z, Beeler JA, Audet SA, Ngala M, Mwangala S, Nkonga-Mwangilwa C, Ryon JJ, Monze M, Kasolo F, Quinn TC, Cousens S, Griffin DE, Cutts FT. Immunogenicity of standard-titer measles vaccine in HIV-1-infected and uninfected Zambian children: an observational study. J Infect Dis. 2007 Aug 01; 196(3):347-55. PMID: 17597448.
    Citations: 30     Fields:    Translation:Humans
  29. Ota MO, Ndhlovu Z, Oh S, Piyasirisilp S, Berzofsky JA, Moss WJ, Griffin DE. Hemagglutinin protein is a primary target of the measles virus-specific HLA-A2-restricted CD8+ T cell response during measles and after vaccination. J Infect Dis. 2007 Jun 15; 195(12):1799-807. PMID: 17492596.
    Citations: 15     Fields:    Translation:HumansCells
  30. Ndhlovu Z, Ryon JJ, Griffin DE, Monze M, Kasolo F, Moss WJ. CD4+ and CD8+ T-lymphocyte subsets in Zambian children. J Trop Pediatr. 2004 04; 50(2):94-7. PMID: 15088798.
    Citations: 6     Fields:    Translation:HumansCells
  31. Fylkesnes K, Musonda RM, Sichone M, Ndhlovu Z, Tembo F, Monze M. Declining HIV prevalence and risk behaviours in Zambia: evidence from surveillance and population-based surveys. AIDS. 2001 May 04; 15(7):907-16. PMID: 11399963.
    Citations: 43     Fields:    Translation:HumansCellsPHPublic Health
  32. Fylkesnes K, Ndhlovu Z, Kasumba K, Mubanga Musonda R, Sichone M. Studying dynamics of the HIV epidemic: population-based data compared with sentinel surveillance in Zambia. AIDS. 1998 Jul 09; 12(10):1227-34. PMID: 9677172.
    Citations: 38     Fields:    Translation:HumansCellsPHPublic Health
  33. Fylkesnes K, Musonda RM, Kasumba K, Ndhlovu Z, Mluanda F, Kaetano L, Chipaila CC. The HIV epidemic in Zambia: socio-demographic prevalence patterns and indications of trends among childbearing women. AIDS. 1997 Mar; 11(3):339-45. PMID: 9147426.
    Citations: 28     Fields:    Translation:HumansPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.