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David Stanley Milstone, M.D.,Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD040895 (MILSTONE, DAVID S) Apr 1, 2003 - Sep 30, 2009
    NIH/NICHD
    PPARg in trophoblast and placental development
    Role: Principal Investigator
  2. R29HL054095 (MILSTONE, DAVID S) Jun 1, 1997 - May 31, 2001
    NIH/NHLBI
    DEVELOPMENTAL BIOLOGY OF THE ENDOTHELIUM
    Role: Principal Investigator
  3. P30AR042689 (KUPPER, THOMAS S.) Apr 1, 1994 - Oct 13, 2011
    NIH/NIAMS
    Harvard Skin Disease Research Center
    Role: Co-Principal Investigator
  4. P01HL036028 (LUSCINSKAS, FRANCIS W.) Jul 1, 1984 - Jun 30, 2014
    NIH/NHLBI
    Pathophysiology of the Endothelium
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Herrmann MD, Clunie DA, Fedorov A, Doyle SW, Pieper S, Klepeis V, Le LP, Mutter GL, Milstone DS, Schultz TJ, Kikinis R, Kotecha GK, Hwang DH, Andriole KP, Iafrate AJ, Brink JA, Boland GW, Dreyer KJ, Michalski M, Golden JA, Louis DN, Lennerz JK. Implementing the DICOM Standard for Digital Pathology. J Pathol Inform. 2018; 9:37. PMID: 30533276.
    Citations:    
  2. O'Donnell PE, Ye XZ, DeChellis MA, Davis VM, Duan SZ, Mortensen RM, Milstone DS. Lipodystrophy, Diabetes and Normal Serum Insulin in PPAR?-Deficient Neonatal Mice. PLoS One. 2016; 11(8):e0160636. PMID: 27505464.
    Citations: 1     Fields:    Translation:Animals
  3. Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar SM, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MI. Differential role of an NF-?B transcriptional response element in endothelial versus intimal cell VCAM-1 expression. Circ Res. 2015 Jul 03; 117(2):166-77. PMID: 26034041.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  4. Tache V, Ciric A, Moretto-Zita M, Li Y, Peng J, Maltepe E, Milstone DS, Parast MM. Hypoxia and trophoblast differentiation: a key role for PPAR?. Stem Cells Dev. 2013 Nov 01; 22(21):2815-24. PMID: 23767827.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  5. Rose JA, Rabenold JJ, Parast MM, Milstone DS, Abrahams VM, Riley JK. Peptidoglycan induces necrosis and regulates cytokine production in murine trophoblast stem cells. Am J Reprod Immunol. 2011 Sep; 66(3):209-22. PMID: 21385270.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Duan SZ, Usher MG, Foley EL, Milstone DS, Brosius FC, Mortensen RM. Sex dimorphic actions of rosiglitazone in generalised peroxisome proliferator-activated receptor-gamma (PPAR-gamma)-deficient mice. Diabetologia. 2010 Jul; 53(7):1493-505. PMID: 20401461.
    Citations: 5     Fields:    Translation:Animals
  7. Parast MM, Yu H, Ciric A, Salata MW, Davis V, Milstone DS. PPARgamma regulates trophoblast proliferation and promotes labyrinthine trilineage differentiation. PLoS One. 2009 Nov 30; 4(11):e8055. PMID: 19956639.
    Citations: 23     Fields:    Translation:AnimalsCells
  8. Ye CP, Duan SZ, Milstone DS, Mortensen RM. G(o) controls the hyperpolarization-activated current in embryonic stem cell-derived cardiocytes. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H979-85. PMID: 18156202.
    Citations:    Fields:    Translation:AnimalsCells
  9. Duan SZ, Christe M, Milstone DS, Mortensen RM. Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice. Biochem Biophys Res Commun. 2007 May 25; 357(1):139-43. PMID: 17418106.
    Citations: 9     Fields:    Translation:Animals
  10. Duan SZ, Ivashchenko CY, Whitesall SE, D'Alecy LG, Duquaine DC, Brosius FC, Gonzalez FJ, Vinson C, Pierre MA, Milstone DS, Mortensen RM. Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J Clin Invest. 2007 Mar; 117(3):812-22. PMID: 17304352.
    Citations: 71     Fields:    Translation:AnimalsCells
  11. Duan SZ, Ivashchenko CY, Russell MW, Milstone DS, Mortensen RM. Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-gamma both induce cardiac hypertrophy in mice. Circ Res. 2005 Aug 19; 97(4):372-9. PMID: 16051889.
    Citations: 82     Fields:    Translation:AnimalsCells
  12. Friedrich EB, Liu E, Sinha S, Cook S, Milstone DS, MacRae CA, Mariotti M, Kuhlencordt PJ, Force T, Rosenzweig A, St-Arnaud R, Dedhar S, Gerszten RE. Integrin-linked kinase regulates endothelial cell survival and vascular development. Mol Cell Biol. 2004 Sep; 24(18):8134-44. PMID: 15340074.
    Citations: 43     Fields:    Translation:AnimalsCells
  13. Yu Y, Moulton KS, Khan MK, Vineberg S, Boye E, Davis VM, O'Donnell PE, Bischoff J, Milstone DS. E-selectin is required for the antiangiogenic activity of endostatin. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8005-10. PMID: 15148373.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  14. Vernochet C, Milstone DS, Iehlé C, Belmonte N, Phillips B, Wdziekonski B, Villageois P, Amri EZ, O'Donnell PE, Mortensen RM, Ailhaud G, Dani C. PPARgamma-dependent and PPARgamma-independent effects on the development of adipose cells from embryonic stem cells. FEBS Lett. 2002 Jan 02; 510(1-2):94-8. PMID: 11755538.
    Citations: 3     Fields:    Translation:AnimalsCells
  15. Jantzen HM, Milstone DS, Gousset L, Conley PB, Mortensen RM. Impaired activation of murine platelets lacking G alpha(i2). J Clin Invest. 2001 Aug; 108(3):477-83. PMID: 11489941.
    Citations: 40     Fields:    Translation:AnimalsCells
  16. Cybulsky MI, Iiyama K, Li H, Zhu S, Chen M, Iiyama M, Davis V, Gutierrez-Ramos JC, Connelly PW, Milstone DS. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest. 2001 May; 107(10):1255-62. PMID: 11375415.
    Citations: 255     Fields:    Translation:Animals
  17. Jain M, Lim CC, Nagata K, Davis VM, Milstone DS, Liao R, Mortensen RM. Targeted inactivation of Galpha(i) does not alter cardiac function or beta-adrenergic sensitivity. Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H569-75. PMID: 11158953.
    Citations: 10     Fields:    Translation:AnimalsCells
  18. Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW. The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat Med. 2001 Jan; 7(1):41-7. PMID: 11135614.
    Citations: 105     Fields:    Translation:AnimalsCells
  19. Nagata K, Ye C, Jain M, Milstone DS, Liao R, Mortensen RM. Galpha(i2) but not Galpha(i3) is required for muscarinic inhibition of contractility and calcium currents in adult cardiomyocytes. Circ Res. 2000 Nov 10; 87(10):903-9. PMID: 11073886.
    Citations: 24     Fields:    Translation:AnimalsCells
  20. Milstone DS, Redline RW, O'Donnell PE, Davis VM, Stavrakis G. E-selectin expression and function in a unique placental trophoblast population at the fetal-maternal interface: regulation by a trophoblast-restricted transcriptional mechanism conserved between humans and mice. Dev Dyn. 2000 Sep; 219(1):63-76. PMID: 10974672.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. Milstone DS, O'Donnell PE, Stavrakis G, Mortensen RM, Davis VM. E-selectin expression and stimulation by inflammatory mediators are developmentally regulated during embryogenesis. Lab Invest. 2000 Jun; 80(6):943-54. PMID: 10879744.
    Citations: 3     Fields:    Translation:AnimalsCells
  22. Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM. PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell. 1999 Oct; 4(4):611-7. PMID: 10549292.
    Citations: 491     Fields:    Translation:AnimalsCells
  23. Ye C, Sowell MO, Vassilev PM, Milstone DS, Mortensen RM. Galpha(i2), Galpha(i3)and Galpha(o) are all required for normal muscarinic inhibition of the cardiac calcium channels in nodal/atrial-like cultured cardiocytes. J Mol Cell Cardiol. 1999 Sep; 31(9):1771-81. PMID: 10471359.
    Citations: 5     Fields:    Translation:AnimalsCells
  24. Milstone DS, Bradwin G, Mortensen RM. Simultaneous Cre catalyzed recombination of two alleles to restore neomycin sensitivity and facilitate homozygous mutations. Nucleic Acids Res. 1999 Aug 01; 27(15):e10. PMID: 10454629.
    Citations: 5     Fields:    Translation:AnimalsCells
  25. Milstone DS, Fukumura D, Padgett RC, O'Donnell PE, Davis VM, Benavidez OJ, Monsky WL, Melder RJ, Jain RK, Gimbrone MA. Mice lacking E-selectin show normal numbers of rolling leukocytes but reduced leukocyte stable arrest on cytokine-activated microvascular endothelium. Microcirculation. 1998; 5(2-3):153-71. PMID: 9789256.
    Citations: 21     Fields:    Translation:AnimalsCells
  26. Gerritsen ME, Shen CP, Atkinson WJ, Padgett RC, Gimbrone MA, Milstone DS. Microvascular endothelial cells from E-selectin-deficient mice form tubes in vitro. Lab Invest. 1996 Aug; 75(2):175-84. PMID: 8765318.
    Citations: 7     Fields:    Translation:AnimalsCells
  27. Gerritsen ME, Shen CP, McHugh MC, Atkinson WJ, Kiely JM, Milstone DS, Luscinskas FW, Gimbrone MA. Activation-dependent isolation and culture of murine pulmonary microvascular endothelium. Microcirculation. 1995 Aug; 2(2):151-63. PMID: 7497167.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  28. Rimm IJ, Fruman DA, Abhyankar S, Sakamoto H, Orme IM, Milstone D, Seidman JG, Ferrara JL. T cell receptor (beta chain) transgenic mice have selective deficits in gamma delta T cell subpopulations. Transpl Immunol. 1994 Sep; 2(3):218-24. PMID: 8000850.
    Citations:    Fields:    Translation:AnimalsCells
  29. Huttner KM, Pudney J, Milstone DS, Ladd D, Seidman JG. Flagellar and acrosomal abnormalities associated with testicular HSV-tk expression in the mouse. Biol Reprod. 1993 Aug; 49(2):251-61. PMID: 8396994.
    Citations: 5     Fields:    Translation:AnimalsCells
  30. Milstone DS, Shaw SK, Parker KL, Szyf M, Seidman JG. An element regulating adrenal-specific steroid 21-hydroxylase expression is located within the slp gene. J Biol Chem. 1992 Oct 25; 267(30):21924-7. PMID: 1400503.
    Citations: 3     Fields:    Translation:AnimalsCells
  31. Szyf M, Milstone DS, Schimmer BP, Parker KL, Seidman JG. cis modification of the steroid 21-hydroxylase gene prevents its expression in the Y1 mouse adrenocortical tumor cell line. Mol Endocrinol. 1990 Aug; 4(8):1144-52. PMID: 1705655.
    Citations: 5     Fields:    Translation:AnimalsCells
  32. Milstone DS, Parker CW. The glycoprotein nature and biosynthetic relationship of two molecularly distinct species of primate T-cell growth factor. Biochem J. 1986 Jun 01; 236(2):371-7. PMID: 3489463.
    Citations:    Fields:    Translation:AnimalsCells
  33. Howe RC, Milstone DS, Ratliff TL, Russell JH. Interleukin 2-mediated induction of lytic activity in a cloned murine CTL line. J Immunol. 1985 Apr; 134(4):2414-8. PMID: 2579143.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  34. Milstone DS, Parker CW. Purification of primate T cell growth factor to apparent homogeneity by reverse phase high pressure liquid chromatography: evidence for two highly active molecularly distinct species. Biochem Biophys Res Commun. 1983 Sep 15; 115(2):762-8. PMID: 6605146.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  35. Milstone DS, Vold BS, Glitz DG, Shutt N. Antibodies to N6-(delta2-isopentenyl) adenosine and its nucleotide: interaction with purified tRNAs and with bases, nucleosides and nucleotides of the isopentenyladenosine family. Nucleic Acids Res. 1978 Sep; 5(9):3439-55. PMID: 81480.
    Citations: 12     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.