Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Young-Bum Kim, Ph.D.

Title
Institution
Department
Address
Phone
Fax
Profile Picture

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK106076 (KIM, YOUNG-BUM) Jul 1, 2017 - Jun 30, 2021
    NIH/NIDDK
    Control of Energy Balance by ApoJ Signaling
    Role: Principal Investigator
  2. R01DK111529 (KIM, YOUNG-BUM) Sep 20, 2016 - Jul 31, 2021
    NIH/NIDDK
    ApoJ as a novel hepatokine targeting muscle glucose metabolism
    Role: Principal Investigator
  3. R01DK094040 (KIM, YOUNG-BUM) May 19, 2012 - Apr 30, 2016
    NIH/NIDDK
    Leptin Signaling in Hypothalamic Neurons and Glutamate Receptors
    Role: Principal Investigator
  4. R01DK083567 (KIM, YOUNG-BUM) Apr 1, 2009 - Feb 28, 2019
    NIH/NIDDK
    ROCK1 signaling in glucose metabolism
    Role: Principal Investigator
  5. R21DK075943 (KIM, YOUNG-BUM) Jul 1, 2006 - Jun 30, 2009
    NIH/NIDDK
    In vivo role of Rho-kinase in glucose metabolism
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Huang H, Lee SH, Sousa-Lima I, Kim SS, Hwang WM, Dagon Y, Yang WM, Cho S, Kang MC, Seo JA, Shibata M, Cho H, Belew GD, Bhin J, Desai BN, Ryu MJ, Shong M, Li P, Meng H, Chung BH, Hwang D, Kim MS, Park KS, Macedo MP, White M, Jones J, Kim YB. Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition. J Clin Invest. 2018 Dec 03; 128(12):5335-5350. PMID: 30226474.
    Citations:    
  2. Oh AR, Sohn S, Lee J, Park JM, Nam KT, Hahm KB, Kim YB, Lee HJ, Cha JY. ChREBP deficiency leads to diarrhea-predominant irritable bowel syndrome. Metabolism. 2018 08; 85:286-297. PMID: 29669261.
    Citations:    Fields:    
  3. Diep DTV, Hong K, Khun T, Zheng M, Ul-Haq A, Jun HS, Kim YB, Chun KH. Anti-adipogenic effects of KD025 (SLx-2119), a ROCK2-specific inhibitor, in 3T3-L1 cells. Sci Rep. 2018 02 06; 8(1):2477. PMID: 29410516.
    Citations:    Fields:    Translation:AnimalsCells
  4. Seo JA, Kang MC, Ciaraldi TP, Kim SS, Park KS, Choe C, Hwang WM, Lim DM, Farr O, Mantzoros C, Henry RR, Kim YB. Circulating ApoJ is closely associated with insulin resistance in human subjects. Metabolism. 2018 01; 78:155-166. PMID: 28986164.
    Citations:    Fields:    Translation:Humans
  5. Kim SS, Song SH, Kim JH, Jeon YK, Kim BH, Kang MC, Chun SW, Hong SH, Chung M, Kim YK, Kim IJ, Kim YB. Urine clusterin/apolipoprotein J is linked to tubular damage and renal outcomes in patients with type 2 diabetes mellitus. Clin Endocrinol (Oxf). 2017 Aug; 87(2):156-164. PMID: 28434209.
    Citations:    Fields:    Translation:Humans
  6. Han JH, Oh TJ, Lee G, Maeng HJ, Lee DH, Kim KM, Choi SH, Jang HC, Lee HS, Park KS, Kim YB, Lim S. The beneficial effects of empagliflozin, an SGLT2 inhibitor, on atherosclerosis in ApoE -/- mice fed a western diet. Diabetologia. 2017 02; 60(2):364-376. PMID: 27866224.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  7. Lim S, Lee GY, Park HS, Lee DH, Tae Jung O, Kyoung Min K, Kim YB, Jun HS, Hak Chul J, Park KS. Attenuation of carotid neointimal formation after direct delivery of a recombinant adenovirus expressing glucagon-like peptide-1 in diabetic rats. Cardiovasc Res. 2017 02; 113(2):183-194. PMID: 27702762.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Sousa-Lima I, Park SY, Chung M, Jung HJ, Kang MC, Gaspar JM, Seo JA, Macedo MP, Park KS, Mantzoros C, Lee SH, Kim YB. Methylsulfonylmethane (MSM), an organosulfur compound, is effective against obesity-induced metabolic disorders in mice. Metabolism. 2016 10; 65(10):1508-21. PMID: 27621186.
    Citations: 2     Fields:    Translation:AnimalsCells
  9. Lee SH, Zabolotny JM, Huang H, Lee H, Kim YB. Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood. Mol Metab. 2016 Aug; 5(8):589-601. PMID: 27656397.
    Citations: 6     Fields:    
  10. Rhee M, Lee SH, Kim JW, Ham DS, Park HS, Yang HK, Shin JY, Cho JH, Kim YB, Youn BS, Sul HS, Yoon KH. Preadipocyte factor 1 induces pancreatic ductal cell differentiation into insulin-producing cells. Sci Rep. 2016 Apr 05; 6:23960. PMID: 27044861.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  11. Kang MC, Kang N, Kim SY, Lima IS, Ko SC, Kim YT, Kim YB, Jeung HD, Choi KS, Jeon YJ. Popular edible seaweed, Gelidium amansii prevents against diet-induced obesity. Food Chem Toxicol. 2016 Apr; 90:181-7. PMID: 26911551.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Kang MC, Kang N, Ko SC, Kim YB, Jeon YJ. Anti-obesity effects of seaweeds of Jeju Island on the differentiation of 3T3-L1 preadipocytes and obese mice fed a high-fat diet. Food Chem Toxicol. 2016 Apr; 90:36-44. PMID: 26845612.
    Citations: 8     Fields:    Translation:AnimalsCells
  13. Moon PG, Lee JE, Cho YE, Lee SJ, Jung JH, Chae YS, Bae HI, Kim YB, Kim IS, Park HY, Baek MC. Identification of Developmental Endothelial Locus-1 on Circulating Extracellular Vesicles as a Novel Biomarker for Early Breast Cancer Detection. Clin Cancer Res. 2016 Apr 01; 22(7):1757-66. PMID: 26603257.
    Citations: 15     Fields:    Translation:HumansCells
  14. Lee JE, Moon PG, Cho YE, Kim YB, Kim IS, Park H, Baek MC. Identification of EDIL3 on extracellular vesicles involved in breast cancer cell invasion. J Proteomics. 2016 Jan 10; 131:17-28. PMID: 26463135.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Lim S, Lee KS, Lee JE, Park HS, Kim KM, Moon JH, Choi SH, Park KS, Kim YB, Jang HC. Effect of a new PPAR-gamma agonist, lobeglitazone, on neointimal formation after balloon injury in rats and the development of atherosclerosis. Atherosclerosis. 2015 Nov; 243(1):107-19. PMID: 26363808.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  16. Kim KM, Lee KS, Lee GY, Jin H, Durrance ES, Park HS, Choi SH, Park KS, Kim YB, Jang HC, Lim S. Anti-diabetic efficacy of KICG1338, a novel glycogen synthase kinase-3ß inhibitor, and its molecular characterization in animal models of type 2 diabetes and insulin resistance. Mol Cell Endocrinol. 2015 Jul 05; 409:1-10. PMID: 25802191.
    Citations: 7     Fields:    Translation:Animals
  17. Koo YD, Choi JW, Kim M, Chae S, Ahn BY, Kim M, Oh BC, Hwang D, Seol JH, Kim YB, Park YJ, Chung SS, Park KS. SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle. Diabetes. 2015 Jul; 64(7):2420-31. PMID: 25784542.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Dagon Y, Mantzoros C, Kim YB. Exercising insulin sensitivity: AMPK turns on autophagy! Metabolism. 2015 Jun; 64(6):655-7. PMID: 25819737.
    Citations: 1     Fields:    Translation:Animals
  19. Zandi S, Nakao S, Chun KH, Fiorina P, Sun D, Arita R, Zhao M, Kim E, Schueller O, Campbell S, Taher M, Melhorn MI, Schering A, Gatti F, Tezza S, Xie F, Vergani A, Yoshida S, Ishikawa K, Yamaguchi M, Sasaki F, Schmidt-Ullrich R, Hata Y, Enaida H, Yuzawa M, Yokomizo T, Kim YB, Sweetnam P, Ishibashi T, Hafezi-Moghadam A. ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration. Cell Rep. 2015 Feb 24; 10(7):1173-86. PMID: 25704819.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  20. Byun K, Gil SY, Namkoong C, Youn BS, Huang H, Shin MS, Kang GM, Kim HK, Lee B, Kim YB, Kim MS. Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis. EMBO Rep. 2014 Jul; 15(7):801-8. PMID: 24825475.
    Citations: 10     Fields:    Translation:AnimalsCells
  21. Macedo MP, Lima IS, Gaspar JM, Afonso RA, Patarrão RS, Kim YB, Ribeiro RT. Risk of postprandial insulin resistance: the liver/vagus rapport. Rev Endocr Metab Disord. 2014 Mar; 15(1):67-77. PMID: 24174131.
    Citations: 2     Fields:    Translation:HumansAnimals
  22. Giménez-Cassina A, Garcia-Haro L, Choi CS, Osundiji MA, Lane EA, Huang H, Yildirim MA, Szlyk B, Fisher JK, Polak K, Patton E, Wiwczar J, Godes M, Lee DH, Robertson K, Kim S, Kulkarni A, Distefano A, Samuel V, Cline G, Kim YB, Shulman GI, Danial NN. Regulation of hepatic energy metabolism and gluconeogenesis by BAD. Cell Metab. 2014 Feb 04; 19(2):272-84. PMID: 24506868.
    Citations: 15     Fields:    Translation:AnimalsCells
  23. Dong H, Huang H, Yun X, Kim DS, Yue Y, Wu H, Sutter A, Chavin KD, Otterbein LE, Adams DB, Kim YB, Wang H. Bilirubin increases insulin sensitivity in leptin-receptor deficient and diet-induced obese mice through suppression of ER stress and chronic inflammation. Endocrinology. 2014 Mar; 155(3):818-28. PMID: 24424052.
    Citations: 22     Fields:    Translation:AnimalsCells
  24. Lee SH, Huang H, Choi K, Lee DH, Shi J, Liu T, Chun KH, Seo JA, Lima IS, Zabolotny JM, Wei L, Kim YB. ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance. Am J Physiol Endocrinol Metab. 2014 Feb; 306(3):E332-43. PMID: 24326423.
    Citations: 14     Fields:    Translation:AnimalsCells
  25. Huang H, Lee DH, Zabolotny JM, Kim YB. Metabolic actions of Rho-kinase in periphery and brain. Trends Endocrinol Metab. 2013 Oct; 24(10):506-14. PMID: 23938132.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  26. Huang H, Lee SH, Ye C, Lima IS, Oh BC, Lowell BB, Zabolotny JM, Kim YB. ROCK1 in AgRP neurons regulates energy expenditure and locomotor activity in male mice. Endocrinology. 2013 Oct; 154(10):3660-70. PMID: 23885017.
    Citations: 7     Fields:    Translation:AnimalsCells
  27. Lee Y, Lim S, Hong ES, Kim JH, Moon MK, Chun EJ, Choi SI, Kim YB, Park YJ, Park KS, Jang HC, Choi SH. Serum FGF21 concentration is associated with hypertriglyceridaemia, hyperinsulinaemia and pericardial fat accumulation, independently of obesity, but not with current coronary artery status. Clin Endocrinol (Oxf). 2014 Jan; 80(1):57-64. PMID: 23278761.
    Citations: 12     Fields:    Translation:Humans
  28. Manabe Y, Gollisch KS, Holton L, Kim YB, Brandauer J, Fujii NL, Hirshman MF, Goodyear LJ. Exercise training-induced adaptations associated with increases in skeletal muscle glycogen content. FEBS J. 2013 Feb; 280(3):916-26. PMID: 23206309.
    Citations: 10     Fields:    Translation:Animals
  29. Gurkar AU, Chu K, Raj L, Bouley R, Lee SH, Kim YB, Dunn SE, Mandinova A, Lee SW. Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress. Nat Commun. 2013; 4:2189. PMID: 23877263.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  30. Gil SY, Youn BS, Byun K, Huang H, Namkoong C, Jang PG, Lee JY, Jo YH, Kang GM, Kim HK, Shin MS, Pietrzik CU, Lee B, Kim YB, Kim MS. Clusterin and LRP2 are critical components of the hypothalamic feeding regulatory pathway. Nat Commun. 2013; 4:1862. PMID: 23673647.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  31. Huang H, Kong D, Byun KH, Ye C, Koda S, Lee DH, Oh BC, Lee SW, Lee B, Zabolotny JM, Kim MS, Bjørbæk C, Lowell BB, Kim YB. Rho-kinase regulates energy balance by targeting hypothalamic leptin receptor signaling. Nat Neurosci. 2012 Oct; 15(10):1391-8. PMID: 22941110.
    Citations: 31     Fields:    Translation:AnimalsCells
  32. Chu SH, Park JH, Lee MK, Jekal Y, Ahn KY, Chung JY, Lee DH, Kim ES, Naruse M, Im JA, Kong ID, Kong D, Chung CH, Lee JW, Chung KM, Kim YB, Jeon JY. The association between pentraxin 3 and insulin resistance in obese children at baseline and after physical activity intervention. Clin Chim Acta. 2012 Oct 09; 413(19-20):1430-7. PMID: 22687644.
    Citations: 5     Fields:    Translation:Humans
  33. Cha JY, Kim YB. Sulfated oxysterol 25HC3S as a therapeutic target of non-alcoholic fatty liver disease. Metabolism. 2012 Aug; 61(8):1055-7. PMID: 22592130.
    Citations: 2     Fields:    Translation:AnimalsCells
  34. Lim S, Choi SH, Shin H, Cho BJ, Park HS, Ahn BY, Kang SM, Yoon JW, Jang HC, Kim YB, Park KS. Effect of a dipeptidyl peptidase-IV inhibitor, des-fluoro-sitagliptin, on neointimal formation after balloon injury in rats. PLoS One. 2012; 7(4):e35007. PMID: 22493727.
    Citations: 16     Fields:    Translation:AnimalsCells
  35. Chun KH, Araki K, Jee Y, Lee DH, Oh BC, Huang H, Park KS, Lee SW, Zabolotny JM, Kim YB. Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerization. Endocrinology. 2012 Apr; 153(4):1649-62. PMID: 22355071.
    Citations: 21     Fields:    Translation:AnimalsCells
  36. Yoon JW, Cho BJ, Park HS, Kang SM, Choi SH, Jang HC, Shin H, Lee MJ, Kim YB, Park KS, Lim S. Differential effects of trimetazidine on vascular smooth muscle cell and endothelial cell in response to carotid artery balloon injury in diabetic rats. Int J Cardiol. 2013 Jul 15; 167(1):126-33. PMID: 22240760.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  37. Lee DH, Huang H, Choi K, Mantzoros C, Kim YB. Selective PPAR? modulator INT131 normalizes insulin signaling defects and improves bone mass in diet-induced obese mice. Am J Physiol Endocrinol Metab. 2012 Mar 01; 302(5):E552-60. PMID: 22215652.
    Citations: 9     Fields:    Translation:AnimalsCells
  38. Jeon JY, Kim YB. Is perilipin critical in fat utilization during exercise? Metabolism. 2012 Mar; 61(3):291-2. PMID: 22209667.
    Citations:    Fields:    Translation:Animals
  39. Lee SH, Mantzoros C, Kim YB. Resveratrol: is selectivity opening the key to therapeutic effects? Metabolism. 2012 Mar; 61(3):289-90. PMID: 22075269.
    Citations: 1     Fields:    Translation:AnimalsCells
  40. Lim S, Choi SH, Koo BK, Kang SM, Yoon JW, Jang HC, Choi SM, Lee MG, Lee W, Shin H, Kim YB, Lee HK, Park KS. Effects of aerobic exercise training on C1q tumor necrosis factor a-related protein isoform 5 (myonectin): association with insulin resistance and mitochondrial DNA density in women. J Clin Endocrinol Metab. 2012 Jan; 97(1):E88-93. PMID: 22031510.
    Citations: 11     Fields:    Translation:Humans
  41. Shinozaki S, Choi CS, Shimizu N, Yamada M, Kim M, Zhang T, Shiota G, Dong HH, Kim YB, Kaneki M. Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice. J Biol Chem. 2011 Oct 07; 286(40):34959-75. PMID: 21846719.
    Citations: 19     Fields:    Translation:AnimalsCells
  42. Shin HJ, Park YH, Kim SU, Moon HB, Park DS, Han YH, Lee CH, Lee DS, Song IS, Lee DH, Kim M, Kim NS, Kim DG, Kim JM, Kim SK, Kim YN, Kim SS, Choi CS, Kim YB, Yu DY. Hepatitis B virus X protein regulates hepatic glucose homeostasis via activation of inducible nitric oxide synthase. J Biol Chem. 2011 Aug 26; 286(34):29872-81. PMID: 21690090.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  43. Lim S, Yoon JW, Kang SM, Choi SH, Cho BJ, Kim M, Park HS, Cho HJ, Shin H, Kim YB, Kim HS, Jang HC, Park KS. EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes. PLoS One. 2011; 6(6):e20301. PMID: 21655098.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  44. Aronis KN, Kim YB, Mantzoros CS. Clusterin (apolipoprotein J): wither link with diabetes and cardiometabolic risk? Metabolism. 2011 Jun; 60(6):747-8. PMID: 21333309.
    Citations: 2     Fields:    Translation:Humans
  45. Lim S, Moon MK, Shin H, Kim TH, Cho BJ, Kim M, Park HS, Choi SH, Ko SH, Chung MH, Lee IK, Jang HC, Kim YB, Park KS. Effect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats. Cardiovasc Res. 2011 May 01; 90(2):383-93. PMID: 21245056.
    Citations: 4     Fields:    Translation:AnimalsCells
  46. Chun KH, Choi KD, Lee DH, Jung Y, Henry RR, Ciaraldi TP, Kim YB. In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes. Am J Physiol Endocrinol Metab. 2011 Mar; 300(3):E536-42. PMID: 21189360.
    Citations: 15     Fields:    Translation:HumansCells
  47. Kim HK, Youn BS, Shin MS, Namkoong C, Park KH, Baik JH, Kim JB, Park JY, Lee KU, Kim YB, Kim MS. Hypothalamic Angptl4/Fiaf is a novel regulator of food intake and body weight. Diabetes. 2010 Nov; 59(11):2772-80. PMID: 20798332.
    Citations: 28     Fields:    Translation:Animals
  48. Choi K, Kim YB. Molecular mechanism of insulin resistance in obesity and type 2 diabetes. Korean J Intern Med. 2010 Jun; 25(2):119-29. PMID: 20526383.
    Citations: 38     Fields:    Translation:HumansCells
  49. Han SH, Choi SH, Cho BJ, Lee Y, Lim S, Park YJ, Moon MK, Lee HK, Kang SW, Han DS, Kim YB, Jang HC, Park KS. Serum fibroblast growth factor-21 concentration is associated with residual renal function and insulin resistance in end-stage renal disease patients receiving long-term peritoneal dialysis. Metabolism. 2010 Nov; 59(11):1656-62. PMID: 20423749.
    Citations: 16     Fields:    Translation:Humans
  50. Chung SS, Ahn BY, Kim M, Choi HH, Park HS, Kang S, Park SG, Kim YB, Cho YM, Lee HK, Chung CH, Park KS. Control of adipogenesis by the SUMO-specific protease SENP2. Mol Cell Biol. 2010 May; 30(9):2135-46. PMID: 20194620.
    Citations: 13     Fields:    Translation:AnimalsCells
  51. Jang PG, Namkoong C, Kang GM, Hur MW, Kim SW, Kim GH, Kang Y, Jeon MJ, Kim EH, Lee MS, Karin M, Baik JH, Park JY, Lee KU, Kim YB, Kim MS. NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. J Biol Chem. 2010 Mar 26; 285(13):9706-15. PMID: 20097762.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  52. Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y. Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. Cell Metab. 2009 Dec; 10(6):466-80. PMID: 19945404.
    Citations: 63     Fields:    Translation:Animals
  53. Kienesberger PC, Lee D, Pulinilkunnil T, Brenner DS, Cai L, Magnes C, Koefeler HC, Streith IE, Rechberger GN, Haemmerle G, Flier JS, Zechner R, Kim YB, Kershaw EE. Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling. J Biol Chem. 2009 Oct 30; 284(44):30218-29. PMID: 19723629.
    Citations: 53     Fields:    Translation:AnimalsCells
  54. Lim S, Yoon JW, Choi SH, Park YJ, Lee JJ, Park JH, Lee SB, Kim KW, Lim JY, Kim YB, Park KS, Lee HK, Cho SI, Jang HC. Combined impact of adiponectin and retinol-binding protein 4 on metabolic syndrome in elderly people: the Korean Longitudinal Study on Health and Aging. Obesity (Silver Spring). 2010 Apr; 18(4):826-32. PMID: 19661959.
    Citations: 11     Fields:    Translation:Humans
  55. Park HJ, Zhang Y, Du C, Welzig CM, Madias C, Aronovitz MJ, Georgescu SP, Naggar I, Wang B, Kim YB, Blaustein RO, Karas RH, Liao R, Mathews CE, Galper JB. Role of SREBP-1 in the development of parasympathetic dysfunction in the hearts of type 1 diabetic Akita mice. Circ Res. 2009 Jul 31; 105(3):287-94. PMID: 19423844.
    Citations: 12     Fields:    Translation:AnimalsCells
  56. Lee DH, Shi J, Jeoung NH, Kim MS, Zabolotny JM, Lee SW, White MF, Wei L, Kim YB. Targeted disruption of ROCK1 causes insulin resistance in vivo. J Biol Chem. 2009 May 01; 284(18):11776-80. PMID: 19276091.
    Citations: 45     Fields:    Translation:AnimalsCells
  57. Lim S, Yoon JW, Choi SH, Cho BJ, Kim JT, Chang HS, Park HS, Park KS, Lee HK, Kim YB, Jang HC. Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model. Metabolism. 2009 Jan; 58(1):8-15. PMID: 19059525.
    Citations: 9     Fields:    Translation:AnimalsCells
  58. Ongusaha PP, Qi HH, Raj L, Kim YB, Aaronson SA, Davis RJ, Shi Y, Liao JK, Lee SW. Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage. Sci Signal. 2008 Nov 25; 1(47):ra14. PMID: 19036714.
    Citations: 20     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  59. Lim S, Son KR, Song IC, Park HS, Jin CJ, Jang HC, Park KS, Kim YB, Lee HK. Fat in liver/muscle correlates more strongly with insulin sensitivity in rats than abdominal fat. Obesity (Silver Spring). 2009 Jan; 17(1):188-95. PMID: 18948962.
    Citations: 7     Fields:    Translation:Animals
  60. Villena JA, Choi CS, Wang Y, Kim S, Hwang YJ, Kim YB, Cline G, Shulman GI, Sul HS. Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy. Diabetes. 2008 Dec; 57(12):3258-66. PMID: 18835937.
    Citations: 24     Fields:    Translation:Animals
  61. Choi SH, Kwak SH, Youn BS, Lim S, Park YJ, Lee H, Lee N, Cho YM, Lee HK, Kim YB, Park KS, Jang HC. High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus. J Clin Endocrinol Metab. 2008 Aug; 93(8):3142-8. PMID: 18492757.
    Citations: 17     Fields:    Translation:Humans
  62. Lim S, Choi SH, Jeong IK, Kim JH, Moon MK, Park KS, Lee HK, Kim YB, Jang HC. Insulin-sensitizing effects of exercise on adiponectin and retinol-binding protein-4 concentrations in young and middle-aged women. J Clin Endocrinol Metab. 2008 Jun; 93(6):2263-8. PMID: 18334592.
    Citations: 31     Fields:    Translation:HumansCTClinical Trials
  63. Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem. 2008 May 23; 283(21):14230-41. PMID: 18281274.
    Citations: 104     Fields:    Translation:AnimalsCells
  64. Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest. 2007 Nov; 117(11):3463-74. PMID: 17932564.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  65. Zabolotny JM, Kim YB. Silencing insulin resistance through SIRT1. Cell Metab. 2007 Oct; 6(4):247-9. PMID: 17908551.
    Citations: 4     Fields:    Translation:HumansCells
  66. Xue B, Kim YB, Lee A, Toschi E, Bonner-Weir S, Kahn CR, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance. J Biol Chem. 2007 Aug 17; 282(33):23829-40. PMID: 17545163.
    Citations: 20     Fields:    Translation:AnimalsCells
  67. Ongusaha PP, Kim HG, Boswell SA, Ridley AJ, Der CJ, Dotto GP, Kim YB, Aaronson SA, Lee SW. RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol. 2006 Dec 19; 16(24):2466-72. PMID: 17174923.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  68. Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab. 2006 Dec; 4(6):453-64. PMID: 17141629.
    Citations: 75     Fields:    Translation:AnimalsCells
  69. Kim MS, Pak YK, Jang PG, Namkoong C, Choi YS, Won JC, Kim KS, Kim SW, Kim HS, Park JY, Kim YB, Lee KU. Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis. Nat Neurosci. 2006 Jul; 9(7):901-6. PMID: 16783365.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  70. Aschenbach WG, Ho RC, Sakamoto K, Fujii N, Li Y, Kim YB, Hirshman MF, Goodyear LJ. Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E152-8. PMID: 16478782.
    Citations: 17     Fields:    Translation:AnimalsCells
  71. Park SY, Cho YR, Kim HJ, Higashimori T, Danton C, Lee MK, Dey A, Rothermel B, Kim YB, Kalinowski A, Russell KS, Kim JK. Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Diabetes. 2005 Dec; 54(12):3530-40. PMID: 16306372.
    Citations: 107     Fields:    Translation:Animals
  72. Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB. Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Mol Cell Biol. 2005 Nov; 25(21):9713-23. PMID: 16227617.
    Citations: 14     Fields:    Translation:AnimalsCells
  73. Park SY, Cho YR, Finck BN, Kim HJ, Higashimori T, Hong EG, Lee MK, Danton C, Deshmukh S, Cline GW, Wu JJ, Bennett AM, Rothermel B, Kalinowski A, Russell KS, Kim YB, Kelly DP, Kim JK. Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver. Diabetes. 2005 Sep; 54(9):2514-24. PMID: 16123338.
    Citations: 37     Fields:    Translation:AnimalsCells
  74. Furukawa N, Ongusaha P, Jahng WJ, Araki K, Choi CS, Kim HJ, Lee YH, Kaibuchi K, Kahn BB, Masuzaki H, Kim JK, Lee SW, Kim YB. Role of Rho-kinase in regulation of insulin action and glucose homeostasis. Cell Metab. 2005 Aug; 2(2):119-29. PMID: 16098829.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  75. Haj FG, Zabolotny JM, Kim YB, Kahn BB, Neel BG. Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice. J Biol Chem. 2005 Apr 15; 280(15):15038-46. PMID: 15699041.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  76. Chan JL, Moschos SJ, Bullen J, Heist K, Li X, Kim YB, Kahn BB, Mantzoros CS. Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency. J Clin Endocrinol Metab. 2005 Mar; 90(3):1625-31. PMID: 15613409.
    Citations: 18     Fields:    Translation:HumansCellsCTClinical Trials
  77. Corbould A, Kim YB, Youngren JF, Pender C, Kahn BB, Lee A, Dunaif A. Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling. Am J Physiol Endocrinol Metab. 2005 May; 288(5):E1047-54. PMID: 15613682.
    Citations: 45     Fields:    Translation:HumansCells
  78. Kim MS, Yoon CY, Jang PG, Park YJ, Shin CS, Park HS, Ryu JW, Pak YK, Park JY, Lee KU, Kim SY, Lee HK, Kim YB, Park KS. The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol Endocrinol. 2004 Sep; 18(9):2291-301. PMID: 15178745.
    Citations: 43     Fields:    Translation:AnimalsCells
  79. Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Biol. 2004 Jun; 24(11):5080-7. PMID: 15143198.
    Citations: 32     Fields:    Translation:Animals
  80. Kim HJ, Higashimori T, Park SY, Choi H, Dong J, Kim YJ, Noh HL, Cho YR, Cline G, Kim YB, Kim JK. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes. 2004 Apr; 53(4):1060-7. PMID: 15047622.
    Citations: 139     Fields:    Translation:AnimalsCells
  81. Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature. 2004 Apr 01; 428(6982):569-74. PMID: 15058305.
    Citations: 414     Fields:    Translation:Animals
  82. Zabolotny JM, Haj FG, Kim YB, Kim HJ, Shulman GI, Kim JK, Neel BG, Kahn BB. Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J Biol Chem. 2004 Jun 04; 279(23):24844-51. PMID: 15031294.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  83. Kim YB, Kotani K, Ciaraldi TP, Henry RR, Kahn BB. Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction. Diabetes. 2003 Aug; 52(8):1935-42. PMID: 12882908.
    Citations: 52     Fields:    Translation:HumansCells
  84. Choi CS, Kim YB, Lee FN, Zabolotny JM, Kahn BB, Youn JH. Lactate induces insulin resistance in skeletal muscle by suppressing glycolysis and impairing insulin signaling. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E233-40. PMID: 12110527.
    Citations: 23     Fields:    Translation:AnimalsCells
  85. Kim YB, Shulman GI, Kahn BB. Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3. J Biol Chem. 2002 Sep 06; 277(36):32915-22. PMID: 12095990.
    Citations: 23     Fields:    Translation:AnimalsCells
  86. Zabolotny JM, Bence-Hanulec KK, Stricker-Krongrad A, Haj F, Wang Y, Minokoshi Y, Kim YB, Elmquist JK, Tartaglia LA, Kahn BB, Neel BG. PTP1B regulates leptin signal transduction in vivo. Dev Cell. 2002 Apr; 2(4):489-95. PMID: 11970898.
    Citations: 186     Fields:    Translation:AnimalsCells
  87. Kim YB, Ciaraldi TP, Kong A, Kim D, Chu N, Mohideen P, Mudaliar S, Henry RR, Kahn BB. Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110beta protein levels in skeletal muscle of type 2 diabetic subjects. Diabetes. 2002 Feb; 51(2):443-8. PMID: 11812753.
    Citations: 29     Fields:    Translation:HumansCTClinical Trials
  88. Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Müller C, Carling D, Kahn BB. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature. 2002 Jan 17; 415(6869):339-43. PMID: 11797013.
    Citations: 414     Fields:    Translation:AnimalsCells
  89. Tanner CJ, Koves TR, Cortright RL, Pories WJ, Kim YB, Kahn BB, Dohm GL, Houmard JA. Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men. Am J Physiol Endocrinol Metab. 2002 Jan; 282(1):E147-53. PMID: 11739095.
    Citations: 9     Fields:    Translation:Humans
  90. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001 Jun 15; 105(6):745-55. PMID: 11440717.
    Citations: 188     Fields:    Translation:HumansAnimals
  91. Zabolotny JM, Kim YB, Peroni OD, Kim JK, Pani MA, Boss O, Klaman LD, Kamatkar S, Shulman GI, Kahn BB, Neel BG. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance. Proc Natl Acad Sci U S A. 2001 Apr 24; 98(9):5187-92. PMID: 11309481.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  92. Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 2001 Feb 08; 409(6821):729-33. PMID: 11217863.
    Citations: 287     Fields:    Translation:AnimalsCells
  93. Huppertz C, Fischer BM, Kim YB, Kotani K, Vidal-Puig A, Slieker LJ, Sloop KW, Lowell BB, Kahn BB. Uncoupling protein 3 (UCP3) stimulates glucose uptake in muscle cells through a phosphoinositide 3-kinase-dependent mechanism. J Biol Chem. 2001 Apr 20; 276(16):12520-9. PMID: 11278970.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  94. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol. 2000 Aug; 20(15):5479-89. PMID: 10891488.
    Citations: 247     Fields:    Translation:Animals
  95. Kim YB, Uotani S, Pierroz DD, Flier JS, Kahn BB. In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin. Endocrinology. 2000 Jul; 141(7):2328-39. PMID: 10875232.
    Citations: 49     Fields:    Translation:AnimalsCells
  96. Venable CL, Frevert EU, Kim YB, Fischer BM, Kamatkar S, Neel BG, Kahn BB. Overexpression of protein-tyrosine phosphatase-1B in adipocytes inhibits insulin-stimulated phosphoinositide 3-kinase activity without altering glucose transport or Akt/Protein kinase B activation. J Biol Chem. 2000 Jun 16; 275(24):18318-26. PMID: 10751417.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  97. Kim YB, Peroni OD, Franke TF, Kahn BB. Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats. Diabetes. 2000 May; 49(5):847-56. PMID: 10905496.
    Citations: 24     Fields:    Translation:AnimalsCells
  98. Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest. 1999 Sep; 104(6):733-41. PMID: 10491408.
    Citations: 93     Fields:    Translation:HumansCells
  99. Kim YB, Zhu JS, Zierath JR, Shen HQ, Baron AD, Kahn BB. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle. Diabetes. 1999 Feb; 48(2):310-20. PMID: 10334307.
    Citations: 11     Fields:    Translation:AnimalsCells
  100. Kim YB, Inoue T, Nakajima R, Shirai-Morishita Y, Tokuyama K, Suzuki M. Effect of long-term exercise on gene expression of insulin signaling pathway intermediates in skeletal muscle. Biochem Biophys Res Commun. 1999 Jan 27; 254(3):720-7. PMID: 9920808.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  101. Kim YB, Nakajima R, Matsuo T, Inoue T, Sekine T, Komuro M, Tamura T, Tokuyama K, Suzuki M. Gene expression of insulin signal-transduction pathway intermediates is lower in rats fed a beef tallow diet than in rats fed a safflower oil diet. Metabolism. 1996 Sep; 45(9):1080-8. PMID: 8781294.
    Citations: 2     Fields:    Translation:AnimalsCells
  102. Iwashita S, Kim YB, Miyamoto H, Komuro M, Tokuyama K, Suzuki M. Diurnal rhythm of plasma insulin and glucose in rats made obese by a high fat diet. Horm Metab Res. 1996 Apr; 28(4):199-201. PMID: 8740197.
    Citations:    Fields:    Translation:Animals
  103. Kim Y, Inoue T, Nakajima R, Nakae K, Tamura T, Tokuyama K, Suzuki M. Effects of endurance training on gene expression of insulin signal transduction pathway. Biochem Biophys Res Commun. 1995 May 25; 210(3):766-73. PMID: 7763251.
    Citations: 3     Fields:    Translation:AnimalsCells
  104. Kim Y, Iwashita S, Tamura T, Tokuyama K, Suzuki M. Effect of high-fat diet on the gene expression of pancreatic GLUT2 and glucokinase in rats. Biochem Biophys Res Commun. 1995 Mar 28; 208(3):1092-8. PMID: 7702608.
    Citations: 4     Fields:    Translation:Animals
  105. Kim Y, Tamura T, Iwashita S, Tokuyama K, Suzuki M. Effect of high-fat diet on gene expression of GLUT4 and insulin receptor in soleus muscle. Biochem Biophys Res Commun. 1994 Jul 15; 202(1):519-26. PMID: 8037757.
    Citations: 4     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Kim's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (540)
Explore
_
Co-Authors (30)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.