Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Login and Edit is currently disabled

Manuela Cernadas, M.D.

Title
Institution
Department
Address
Phone

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R01AI051461 (CERNADAS, MANUELA) Feb 1, 2003 - Jan 31, 2009
    NIH
    Cathepsins in Antigen Presentation and Lung Immunity
    Role: Principal Investigator
  2. K08HL004453 (CERNADAS, MANUELA) Sep 1, 2000 - Jul 31, 2005
    NIH
    INTEGRIN CD103-ROLE IN TH2 PULMONARY IMMUNE RESPONSES
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 48 total Publications Show all
  1. Li Y, Choudhary MC, Regan J, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynolds Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. SARS-CoV-2 viral clearance and evolution varies by type and severity of immunodeficiency. Sci Transl Med. 2024 Jan 24; 16(731):eadk1599. PMID: 38266109; PMCID: PMC10982957.
    Citations: 21 Article has an altmetric score of 380
    Fields: MedMedicine (General)SciScienceTranslation:HumansCells
  2. Li Y, Choudhary MC, Regan J, Boucau J, Nathan A, Speidel T, Liew MY, Edelstein GE, Kawano Y, Uddin R, Deo R, Marino C, Getz MA, Reynold Z, Barry M, Gilbert RF, Tien D, Sagar S, Vyas TD, Flynn JP, Hammond SP, Novack LA, Choi B, Cernadas M, Wallace ZS, Sparks JA, Vyas JM, Seaman MS, Gaiha GD, Siedner MJ, Barczak AK, Lemieux JE, Li JZ. SARS-CoV-2 Viral Clearance and Evolution Varies by Extent of Immunodeficiency. medRxiv. 2023 Aug 07. PMID: 37577493; PMCID: PMC10418302.
    Citations: Article has an altmetric score of 53
  3. Chen HX, Cernadas M, Vargas SO, Levy BD, Loscalzo J. Diagnostic Aspirations. N Engl J Med. 2022 08 04; 387(5):452-458. PMID: 35921455.
    Citations: Article has an altmetric score of 15
    Fields: MedMedicine (General)
  4. Varon J, Arciniegas Rubio A, Amador-Munoz D, Corcoran A, DeCorte JA, Isabelle C, Pinilla Vera M, Walker K, Brown L, Cernadas M, Bry L, Yang H, Kitsios GD, McVerry BJ, Morris A, Lee H, Howrylak J, Englert JA, Baron RM. Surfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating Escherichia coli Colonization in the Gut. Crit Care Explor. 2022 May; 4(5):e0699. PMID: 35620769; PMCID: PMC9119639.
    Citations: 3 Article has an altmetric score of 12
  5. Scully KJ, Marchetti P, Sawicki GS, Uluer A, Cernadas M, Cagnina RE, Kennedy JC, Putman MS. The effect of elexacaftor/tezacaftor/ivacaftor (ETI) on glycemia in adults with cystic fibrosis. J Cyst Fibros. 2022 03; 21(2):258-263. PMID: 34531155; PMCID: PMC8918034.
    Citations: 29 Article has an altmetric score of 20
    Fields: PulPulmonary MedicineTranslation:Humans
  6. Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, Solomon IH, Kuo HH, Boucau J, Bowman K, Adhikari UD, Winkler ML, Mueller AA, Hsu TY, Desjardins M, Baden LR, Chan BT, Walker BD, Lichterfeld M, Brigl M, Kwon DS, Kanjilal S, Richardson ET, Jonsson AH, Alter G, Barczak AK, Hanage WP, Yu XG, Gaiha GD, Seaman MS, Cernadas M, Li JZ. Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host. N Engl J Med. 2020 12 03; 383(23):2291-2293. PMID: 33176080; PMCID: PMC7673303.
    Citations: 646 Article has an altmetric score of 4015
    Fields: MedMedicine (General)Translation:HumansCells
  7. Polverino F, Lu B, Quintero JR, Vargas SO, Patel AS, Owen CA, Gerard NP, Gerard C, Cernadas M. CFTR regulates B cell activation and lymphoid follicle development. Respir Res. 2019 Jul 01; 20(1):133. PMID: 31262295; PMCID: PMC6604167.
    Citations: 17 Article has an altmetric score of 3
    Fields: PulPulmonary MedicineTranslation:HumansAnimalsCells
  8. Liang X, Gupta K, Quintero JR, Cernadas M, Kobzik L, Christou H, Pier GB, Owen CA, Çataltepe S. Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia. FASEB J. 2019 03; 33(3):3562-3574. PMID: 30462529; PMCID: PMC6988858.
    Citations: 19 Article has an altmetric score of 1
    Fields: BioBiologyPhyPhysiologyTranslation:AnimalsCells
  9. Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD, National Heart, Lung, and Blood Institute Severe Asthma Research Program-3 Investigators. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 08 03; 3(26). PMID: 30076281; PMCID: PMC6320225.
    Citations: 110 Article has an altmetric score of 146
    Fields: AllAllergy and Immunology
  10. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD, National Heart Lung and Blood Institute’s Severe Asthma Research Program- Investigators. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2018 03 22; 3(6). PMID: 29563345.
    Citations: 2
    Fields: MedMedicine (General)
  11. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD, National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2017 Jul 20; 2(14). PMID: 28724795; PMCID: PMC5518567.
    Citations: 16 Article has an altmetric score of 7
    Fields: MedMedicine (General)
  12. Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators. Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017 Mar 10; 2(9). PMID: 28783702.
    Citations: 48
    Fields: AllAllergy and Immunology
  13. Girodet PO, Nguyen D, Mancini JD, Hundal M, Zhou X, Israel E, Cernadas M. Alternative Macrophage Activation Is Increased in Asthma. Am J Respir Cell Mol Biol. 2016 Oct; 55(4):467-475. PMID: 27248771; PMCID: PMC5070104.
    Citations: 93 Article has an altmetric score of 16
    Fields: CelCell BiologyMolMolecular Biology
  14. Reid B, Girodet PO, Boomer JS, Abdel-Gadir A, Zheng K, Wechsler ME, Bacharier LB, Kunselman SJ, King TS, Israel E, Castro M, Cernadas M, Green JM. Vitamin D3 treatment of vitamin D-insufficient asthmatic patients does not alter immune cell function. J Allergy Clin Immunol. 2016 07; 138(1):286-289.e9. PMID: 26874367; PMCID: PMC4931954.
    Citations: 5 Article has an altmetric score of 3
    Fields: AllAllergy and ImmunologyTranslation:HumansCells
  15. Haspel JA, Chettimada S, Shaik RS, Chu JH, Raby BA, Cernadas M, Carey V, Process V, Hunninghake GM, Ifedigbo E, Lederer JA, Englert J, Pelton A, Coronata A, Fredenburgh LE, Choi AM. Circadian rhythm reprogramming during lung inflammation. Nat Commun. 2014 Sep 11; 5:4753. PMID: 25208554.
    Citations: 110
    Fields: BioBiologySciScienceTranslation:AnimalsCells
  16. Knolle MD, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig VJ, Fyfe SE, Zahid M, Permaul P, Cernadas M, Montano G, Tesfaigzi Y, Sholl L, Kobzik L, Israel E, Owen CA. Adam8 limits the development of allergic airway inflammation in mice. J Immunol. 2013 Jun 15; 190(12):6434-49. PMID: 23670189; PMCID: PMC3679335.
    Citations: 20
    Fields: AllAllergy and ImmunologyTranslation:HumansAnimalsCells
  17. Lai PS, Hofmann O, Baron RM, Cernadas M, Meng QR, Bresler HS, Brass DM, Yang IV, Schwartz DA, Christiani DC, Hide W. Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin. PLoS One. 2013; 8(5):e62910. PMID: 23675439; PMCID: PMC3652821.
    Citations: Article has an altmetric score of 2
    Fields: MedMedicine (General)SciScienceTranslation:AnimalsCells
  18. Barnig C, Cernadas M, Dutile S, Liu X, Perrella MA, Kazani S, Wechsler ME, Israel E, Levy BD. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med. 2013 Feb 27; 5(174):174ra26. PMID: 23447017; PMCID: PMC3823369.
    Citations: 238 Article has an altmetric score of 24
    Fields: MedMedicine (General)SciScienceTranslation:HumansAnimalsCells
  19. Elmasri H, Ghelfi E, Yu CW, Traphagen S, Cernadas M, Cao H, Shi GP, Plutzky J, Sahin M, Hotamisligil G, Cataltepe S. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway. Angiogenesis. 2012 Sep; 15(3):457-68. PMID: 22562362.
    Citations: 68
    Fields: HemHematologyTranslation:HumansAnimalsCells
  20. Lai PS, Fresco JM, Pinilla MA, Macias AA, Brown RD, Englert JA, Hofmann O, Lederer JA, Hide W, Christiani DC, Cernadas M, Baron RM. Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):209-17. PMID: 22517795.
    Citations: 16
    Fields: CelCell BiologyMolMolecular BiologyTranslation:AnimalsCellsPHPublic Health
  21. Chang HH, Tai TS, Lu B, Iannaccone C, Cernadas M, Weinblatt M, Shadick N, Miaw SC, Ho IC. PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis. PLoS One. 2012; 7(3):e33067. PMID: 22427951.
    Citations: 22
    Fields: MedMedicine (General)SciScienceTranslation:HumansCells
  22. Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA. Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011 Nov 15; 187(10):5255-67. PMID: 21967897; PMCID: PMC3208135.
    Citations: 50 Article has an altmetric score of 3
    Fields: AllAllergy and ImmunologyTranslation:HumansAnimalsCells
  23. Cernadas M. It takes a microbiome: commensals, immune regulation, and allergy. Am J Respir Crit Care Med. 2011 Jul 15; 184(2):149-50. PMID: 21765026.
    Citations: 6
    Fields: CriCritical CarePulPulmonary MedicineTranslation:HumansAnimals
  24. Haworth O, Cernadas M, Levy BD. NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation. J Immunol. 2011 Jun 01; 186(11):6129-35. PMID: 21515793; PMCID: PMC3823382.
    Citations: 78 Article has an altmetric score of 6
    Fields: AllAllergy and ImmunologyTranslation:AnimalsCells
  25. Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, Fitzgerald KA, Ryter SW, Choi AM. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011 Mar; 12(3):222-30. PMID: 21151103; PMCID: PMC3079381.
    Citations: 1533 Article has an altmetric score of 16
    Fields: AllAllergy and ImmunologyTranslation:Animals
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contact@catalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resources@hms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappt@hms.harvard.edu.
Cernadas's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (317)
Explore
_
Co-Authors (76)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.