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Manuela Cernadas, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI051461 (CERNADAS, MANUELA) Feb 1, 2003 - Jan 31, 2009
    NIH
    Cathepsins in Antigen Presentation and Lung Immunity
    Role: Principal Investigator
  2. K08HL004453 (CERNADAS, MANUELA) Sep 1, 2000 - Jul 31, 2005
    NIH
    INTEGRIN CD103-ROLE IN TH2 PULMONARY IMMUNE RESPONSES
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, Solomon IH, Kuo HH, Boucau J, Bowman K, Adhikari UD, Winkler ML, Mueller AA, Hsu TY, Desjardins M, Baden LR, Chan BT, Walker BD, Lichterfeld M, Brigl M, Kwon DS, Kanjilal S, Richardson ET, Jonsson AH, Alter G, Barczak AK, Hanage WP, Yu XG, Gaiha GD, Seaman MS, Cernadas M, Li JZ. Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host. N Engl J Med. 2020 12 03; 383(23):2291-2293. PMID: 33176080.
    Citations: 73     Fields:    Translation:Humans
  2. Polverino F, Lu B, Quintero JR, Vargas SO, Patel AS, Owen CA, Gerard NP, Gerard C, Cernadas M. CFTR regulates B cell activation and lymphoid follicle development. Respir Res. 2019 Jul 01; 20(1):133. PMID: 31262295.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  3. Liang X, Gupta K, Quintero JR, Cernadas M, Kobzik L, Christou H, Pier GB, Owen CA, Çataltepe S. Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia. FASEB J. 2019 03; 33(3):3562-3574. PMID: 30462529.
    Citations: 7     Fields:    Translation:AnimalsCells
  4. Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD. Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma. Sci Immunol. 2018 08 03; 3(26). PMID: 30076281.
    Citations: 34     Fields:    
  5. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2018 03 22; 3(6). PMID: 29563345.
    Citations: 3     Fields:    
  6. Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD. ALX receptor ligands define a biochemical endotype for severe asthma. JCI Insight. 2017 Jul 20; 2(14). PMID: 28724795.
    Citations: 9     Fields:    
  7. Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD. Natural killer cell-mediated inflammation resolution is disabled in severe asthma. Sci Immunol. 2017 Mar 10; 2(9). PMID: 28783702.
    Citations: 19     Fields:    
  8. Girodet PO, Nguyen D, Mancini JD, Hundal M, Zhou X, Israel E, Cernadas M. Alternative Macrophage Activation Is Increased in Asthma. Am J Respir Cell Mol Biol. 2016 Oct; 55(4):467-475. PMID: 27248771.
    Citations: 40     Fields:    
  9. Reid B, Girodet PO, Boomer JS, Abdel-Gadir A, Zheng K, Wechsler ME, Bacharier LB, Kunselman SJ, King TS, Israel E, Castro M, Cernadas M, Green JM. Vitamin D3 treatment of vitamin D-insufficient asthmatic patients does not alter immune cell function. J Allergy Clin Immunol. 2016 07; 138(1):286-289.e9. PMID: 26874367.
    Citations: 3     Fields:    Translation:HumansCells
  10. Haspel JA, Chettimada S, Shaik RS, Chu JH, Raby BA, Cernadas M, Carey V, Process V, Hunninghake GM, Ifedigbo E, Lederer JA, Englert J, Pelton A, Coronata A, Fredenburgh LE, Choi AM. Circadian rhythm reprogramming during lung inflammation. Nat Commun. 2014 Sep 11; 5:4753. PMID: 25208554.
    Citations: 45     Fields:    Translation:AnimalsCells
  11. Lai PS, Hofmann O, Baron RM, Cernadas M, Meng QR, Bresler HS, Brass DM, Yang IV, Schwartz DA, Christiani DC, Hide W. Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin. PLoS One. 2013; 8(5):e62910. PMID: 23675439.
    Citations:    Fields:    Translation:AnimalsCells
  12. Knolle MD, Nakajima T, Hergrueter A, Gupta K, Polverino F, Craig VJ, Fyfe SE, Zahid M, Permaul P, Cernadas M, Montano G, Tesfaigzi Y, Sholl L, Kobzik L, Israel E, Owen CA. Adam8 limits the development of allergic airway inflammation in mice. J Immunol. 2013 Jun 15; 190(12):6434-49. PMID: 23670189.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  13. Barnig C, Cernadas M, Dutile S, Liu X, Perrella MA, Kazani S, Wechsler ME, Israel E, Levy BD. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med. 2013 Feb 27; 5(174):174ra26. PMID: 23447017.
    Citations: 185     Fields:    Translation:HumansAnimalsCells
  14. Elmasri H, Ghelfi E, Yu CW, Traphagen S, Cernadas M, Cao H, Shi GP, Plutzky J, Sahin M, Hotamisligil G, Cataltepe S. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway. Angiogenesis. 2012 Sep; 15(3):457-68. PMID: 22562362.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  15. Lai PS, Fresco JM, Pinilla MA, Macias AA, Brown RD, Englert JA, Hofmann O, Lederer JA, Hide W, Christiani DC, Cernadas M, Baron RM. Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):209-17. PMID: 22517795.
    Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
  16. Chang HH, Tai TS, Lu B, Iannaccone C, Cernadas M, Weinblatt M, Shadick N, Miaw SC, Ho IC. PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis. PLoS One. 2012; 7(3):e33067. PMID: 22427951.
    Citations: 13     Fields:    Translation:HumansCells
  17. Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA. Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011 Nov 15; 187(10):5255-67. PMID: 21967897.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  18. Cernadas M. It takes a microbiome: commensals, immune regulation, and allergy. Am J Respir Crit Care Med. 2011 Jul 15; 184(2):149-50. PMID: 21765026.
    Citations: 6     Fields:    Translation:HumansAnimals
  19. Haworth O, Cernadas M, Levy BD. NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammation. J Immunol. 2011 Jun 01; 186(11):6129-35. PMID: 21515793.
    Citations: 56     Fields:    Translation:AnimalsCells
  20. Nakahira K, Haspel JA, Rathinam VA, Lee SJ, Dolinay T, Lam HC, Englert JA, Rabinovitch M, Cernadas M, Kim HP, Fitzgerald KA, Ryter SW, Choi AM. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol. 2011 Mar; 12(3):222-30. PMID: 21151103.
    Citations: 1021     Fields:    Translation:Animals
  21. Kiener HP, Watts GF, Cui Y, Wright J, Thornhill TS, Sköld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, Lee DM. Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture. Arthritis Rheum. 2010 Mar; 62(3):742-52. PMID: 20131230.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  22. Muindi K, Cernadas M, Watts GF, Royle L, Neville DC, Dwek RA, Besra GS, Rudd PM, Butters TD, Brenner MB. Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected]. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):3052-7. PMID: 20133624.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  23. Cernadas M, Cavallari M, Watts G, Mori L, De Libero G, Brenner MB. Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens. J Immunol. 2010 Feb 01; 184(3):1235-41. PMID: 20026739.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  24. Cernadas M, Lu J, Watts G, Brenner MB. CD1a expression defines an interleukin-12 producing population of human dendritic cells. Clin Exp Immunol. 2009 Mar; 155(3):523-33. PMID: 19220838.
    Citations: 32     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  25. Haworth O, Cernadas M, Yang R, Serhan CN, Levy BD. Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat Immunol. 2008 Aug; 9(8):873-9. PMID: 18568027.
    Citations: 163     Fields:    Translation:Animals
  26. Robbins CS, Franco F, Mouded M, Cernadas M, Shapiro SD. Cigarette smoke exposure impairs dendritic cell maturation and T cell proliferation in thoracic lymph nodes of mice. J Immunol. 2008 May 15; 180(10):6623-8. PMID: 18453581.
    Citations: 31     Fields:    Translation:AnimalsCellsPHPublic Health
  27. Wang Y, Baron RM, Zhu G, Joo M, Christman JW, Silverman ES, Perrella MA, Riese RJ, Cernadas M. PU.1 regulates cathepsin S expression in professional APCs. J Immunol. 2006 Jan 01; 176(1):275-83. PMID: 16365419.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  28. Sugita M, Cernadas M, Brenner MB. New insights into pathways for CD1-mediated antigen presentation. Curr Opin Immunol. 2004 Feb; 16(1):90-5. PMID: 14734115.
    Citations: 13     Fields:    Translation:HumansAnimals
  29. Cernadas M, Sugita M, van der Wel N, Cao X, Gumperz JE, Maltsev S, Besra GS, Behar SM, Peters PJ, Brenner MB. Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development. J Immunol. 2003 Oct 15; 171(8):4149-55. PMID: 14530337.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  30. Dodge IL, Carr MW, Cernadas M, Brenner MB. IL-6 production by pulmonary dendritic cells impedes Th1 immune responses. J Immunol. 2003 May 01; 170(9):4457-64. PMID: 12707321.
    Citations: 57     Fields:    Translation:AnimalsCells
  31. Strauch UG, Mueller RC, Li XY, Cernadas M, Higgins JM, Binion DG, Parker CM. Integrin alpha E(CD103)beta 7 mediates adhesion to intestinal microvascular endothelial cell lines via an E-cadherin-independent interaction. J Immunol. 2001 Mar 01; 166(5):3506-14. PMID: 11207310.
    Citations: 21     Fields:    Translation:HumansCells
  32. Higgins JM, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner MB. The role of alpha and beta chains in ligand recognition by beta 7 integrins. J Biol Chem. 2000 Aug 18; 275(33):25652-64. PMID: 10837471.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  33. Mark DA, Donovan CE, De Sanctis GT, He HZ, Cernadas M, Kobzik L, Perkins DL, Sharpe A, Finn PW. B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2000 Mar; 22(3):265-71. PMID: 10696062.
    Citations: 8     Fields:    Translation:Animals
  34. Cernadas M, De Sanctis GT, Krinzman SJ, Mark DA, Donovan CE, Listman JA, Kobzik L, Kikutani H, Christiani DC, Perkins DL, Finn PW. CD23 and allergic pulmonary inflammation: potential role as an inhibitor. Am J Respir Cell Mol Biol. 1999 Jan; 20(1):1-8. PMID: 9870911.
    Citations: 11     Fields:    Translation:AnimalsCells
  35. Cernadas MR, Sánchez de Miguel L, García-Durán M, González-Fernández F, Millás I, Montón M, Rodrigo J, Rico L, Fernández P, de Frutos T, Rodríguez-Feo JA, Guerra J, Caramelo C, Casado S. Expression of constitutive and inducible nitric oxide synthases in the vascular wall of young and aging rats. Circ Res. 1998 Aug 10; 83(3):279-86. PMID: 9710120.
    Citations: 82     Fields:    Translation:Animals
  36. Tan D, Cernadas MR, Aragoncillo P, Castilla MA, Alvarez Arroyo MV, López Farré AJ, Casado S, Caramelo C. Role of nitric oxide-related mechanisms in renal function in ageing rats. Nephrol Dial Transplant. 1998 Mar; 13(3):594-601. PMID: 9550633.
    Citations: 1     Fields:    Translation:Animals
  37. Krinzman SJ, De Sanctis GT, Cernadas M, Mark D, Wang Y, Listman J, Kobzik L, Donovan C, Nassr K, Katona I, Christiani DC, Perkins DL, Finn PW. Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model. J Clin Invest. 1996 Dec 15; 98(12):2693-9. PMID: 8981913.
    Citations: 22     Fields:    Translation:AnimalsCells
  38. Caramelo C, Espinosa G, Manzarbeitia F, Cernadas MR, Pérez Tejerizo G, Tan D, Mosquera JR, Digiuni E, Montón M, Millás I, Hernando L, Casado S, López-Farré A. Role of endothelium-related mechanisms in the pathophysiology of renal ischemia/reperfusion in normal rabbits. Circ Res. 1996 Nov; 79(5):1031-8. PMID: 8888696.
    Citations: 10     Fields:    Translation:AnimalsCells
  39. Krinzman SJ, De Sanctis GT, Cernadas M, Kobzik L, Listman JA, Christiani DC, Perkins DL, Finn PW. T cell activation in a murine model of asthma. Am J Physiol. 1996 Sep; 271(3 Pt 1):L476-83. PMID: 8843798.
    Citations: 12     Fields:    Translation:AnimalsCells
  40. Espinosa G, López Farré A, Cernadas MR, Manzarbeitia F, Tan D, Digiuni E, Mosquera JR, Montón M, Millás I, Hernando L, Casado S, Caramelo C. Role of endothelin in the pathophysiology of renal ischemia-reperfusion in normal rabbits. Kidney Int. 1996 Sep; 50(3):776-82. PMID: 8872951.
    Citations: 8     Fields:    Translation:AnimalsCells
  41. López-Farré A, Riesco A, Digiuni E, Mosquera JR, Caramelo C, de Miguel LS, Millás I, de Frutos T, Cernadas MR, Montón M, Alonso J, Casado S. Aspirin-stimulated nitric oxide production by neutrophils after acute myocardial ischemia in rabbits. Circulation. 1996 Jul 01; 94(1):83-7. PMID: 8964122.
    Citations: 2     Fields:    Translation:AnimalsCells
  42. López Farré A, Riesco A, Espinosa G, Digiuni E, Cernadas MR, Alvarez V, Montón M, Rivas F, Gallego MJ, Egido J, et al. Effect of endothelin-1 on neutrophil adhesion to endothelial cells and perfused heart. Circulation. 1993 Sep; 88(3):1166-71. PMID: 8394784.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  43. Cernadas MR, López-Farré A, Riesco A, Gallego MJ, Espinosa G, Digiuni E, Hernando L, Casado S, Caramelo C. Renal and systemic effects of aminoacids administered separately: comparison between L-arginine and non-nitric oxide donor aminoacids. J Pharmacol Exp Ther. 1992 Dec; 263(3):1023-9. PMID: 1335051.
    Citations: 2     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.