Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles

Annalisa Di Ruscio, Ph.D., M.D.


2007 - 2008
2009 - 2012
T32 HL007917-11A1 Beth Israel Deaconess Medical Center, Boston, USA
2012 - 2013
Tito Bastianello fellowship

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Li M, Cascino P, Ummarino S, Di Ruscio A. Application of Induced Pluripotent Stem Cell Technology to the Study of Hematological Diseases. Cells. 2017 Mar 08; 6(1). PMID: 28282903.
    View in: PubMed
  2. Di Ruscio A, Patti F, Welner RS, Tenen DG, Amabile G. Multiple sclerosis: getting personal with induced pluripotent stem cells. Cell Death Dis. 2016 Apr 14; 7:e2185. PMID: 27077801; PMCID: PMC4855652.
  3. D'Amico MA, Ghinassi B, Izzicupo P, Di Ruscio A, Di Baldassarre A. IL-6 Activates PI3K and PKC? Signaling and Determines Cardiac Differentiation in Rat Embryonic H9c2 Cells. J Cell Physiol. 2016 Mar; 231(3):576-86. PMID: 26205888.
    View in: PubMed
  4. Di Ruscio A, Welner RS, Tenen DG, Amabile G. The second hit of DNA methylation. Mol Cell Oncol. 2016 May; 3(3):e1093690. PMID: 27314082; PMCID: PMC4909463 [Available on 10/29/16].
  5. Di Ruscio A, Patti F, Welner RS, Tenen DG, Amabile G. Multiple sclerosis: getting personal with induced pluripotent stem cells. Cell Death Dis. 2015 Jul 09; 6:e1806. PMID: 26158512; PMCID: PMC4650727.
  6. Amabile G, Di Ruscio A, Müller F, Welner RS, Yang H, Ebralidze AK, Zhang H, Levantini E, Qi L, Martinelli G, Brummelkamp T, Le Beau MM, Figueroa ME, Bock C, Tenen DG. Dissecting the role of aberrant DNA methylation in human leukaemia. Nat Commun. 2015 May 22; 6:7091. PMID: 25997600; PMCID: PMC4443494.
  7. Welner RS, Amabile G, Bararia D, Czibere A, Yang H, Zhang H, Pontes LL, Ye M, Levantini E, Di Ruscio A, Martinelli G, Tenen DG. Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells. Cancer Cell. 2015 May 11; 27(5):671-81. PMID: 25965572; PMCID: PMC4447336.
  8. Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG. The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. Blood. 2014 Oct 09; 124(15):2391-9. PMID: 25185713; PMCID: PMC4192750.
  9. Focosi D, Amabile G, Di Ruscio A, Quaranta P, Tenen DG, Pistello M. Induced pluripotent stem cells in hematology: current and future applications. Blood Cancer J. 2014 May 09; 4:e211. PMID: 24813079; PMCID: PMC4042300.
  10. Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Di Ruscio A, Diruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG. Sox4 is a key oncogenic target in C/EBPa mutant acute myeloid leukemia. Cancer Cell. 2013 Nov 11; 24(5):575-88. PMID: 24183681; PMCID: PMC4038627.
  11. Di Ruscio A, Ebralidze AK, Benoukraf T, Amabile G, Goff LA, Terragni J, Figueroa ME, De Figueiredo Pontes LL, Alberich-Jorda M, Zhang P, Wu M, D'Alò F, Melnick A, Leone G, Ebralidze KK, Pradhan S, Rinn JL, Tenen DG. DNMT1-interacting RNAs block gene-specific DNA methylation. Nature. 2013 Nov 21; 503(7476):371-6. PMID: 24107992; PMCID: PMC3870304.
  12. Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG. In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood. 2013 Feb 21; 121(8):1255-64. PMID: 23212524; PMCID: PMC3701251.
  13. Alberich-Jordà M, Wouters B, Balastik M, Shapiro-Koss C, Zhang H, Di Ruscio A, DiRuscio A, Radomska HS, Ebralidze AK, Amabile G, Ye M, Zhang J, Lowers I, Avellino R, Melnick A, Figueroa ME, Valk PJ, Delwel R, Tenen DG. C/EBP? deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest. 2012 Dec; 122(12):4490-504. PMID: 23160200; PMCID: PMC3533560.
  14. Giachelia M, D'Alò F, Fabiani E, Saulnier N, Di Ruscio A, Guidi F, Hohaus S, Voso MT, Leone G. Gene expression profiling of myelodysplastic CD34+ hematopoietic stem cells treated in vitro with decitabine. Leuk Res. 2011 Apr; 35(4):465-71. PMID: 20869114.
    View in: PubMed
  15. Greco M, D'Alò F, Scardocci A, Criscuolo M, Fabiani E, Guidi F, Di Ruscio A, Migliara G, Pagano L, Fianchi L, Chiusolo P, Hohaus S, Leone G, Voso MT. Promoter methylation of DAPK1, E-cadherin and thrombospondin-1 in de novo and therapy-related myeloid neoplasms. Blood Cells Mol Dis. 2010 Oct 15; 45(3):181-5. PMID: 20655775.
    View in: PubMed
  16. O'Brien KB, Alberich-Jordà M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010 Jul; 137(13):2147-56. PMID: 20530543; PMCID: PMC2882134.
  17. Guibal FC, Alberich-Jorda M, Hirai H, Ebralidze A, Levantini E, Di Ruscio A, Zhang P, Santana-Lemos BA, Neuberg D, Wagers AJ, Rego EM, Tenen DG. Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia. Blood. 2009 Dec 24; 114(27):5415-25. PMID: 19797526; PMCID: PMC2798860.
  18. Fabiani E, D'Alò F, Scardocci A, Greco M, Di Ruscio A, Criscuolo M, Fianchi L, Pagano L, Hohaus S, Leone G, Voso MT. Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes. Leuk Res. 2009 Aug; 33(8):1068-71. PMID: 19027952.
    View in: PubMed
  19. D'Alò F, Di Ruscio A, Guidi F, Fabiani E, Greco M, Rumi C, Hohaus S, Voso MT, Leone G. PU.1 and CEBPA expression in acute myeloid leukemia. Leuk Res. 2008 Sep; 32(9):1448-53. PMID: 18308386.
    View in: PubMed
  20. Voso MT, Fabiani E, D'Alo' F, Guidi F, Di Ruscio A, Sica S, Pagano L, Greco M, Hohaus S, Leone G. Increased risk of acute myeloid leukaemia due to polymorphisms in detoxification and DNA repair enzymes. Ann Oncol. 2007 Sep; 18(9):1523-8. PMID: 17761709.
    View in: PubMed
  21. Koschmieder S, D'Alò F, Radomska H, Schöneich C, Chang JS, Konopleva M, Kobayashi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R, Sargin B, Kantarjian H, Andreeff M, Sporn MB, Perrotti D, Berdel WE, Müller-Tidow C, Serve H, Tenen DG. CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha. Blood. 2007 Nov 15; 110(10):3695-705. PMID: 17671235; PMCID: PMC2077317.
  22. Scardocci A, Guidi F, D'Alo' F, Gumiero D, Fabiani E, Diruscio A, Martini M, Larocca LM, Zollino M, Hohaus S, Leone G, Voso MT. Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia. Br J Cancer. 2006 Oct 23; 95(8):1108-13. PMID: 17047656; PMCID: PMC2360697.
  23. Hohaus S, Di Ruscio A, Di Febo A, Massini G, D'Alo' F, Guidi F, Mansueto G, Voso MT, Leone G. Glutathione S-transferase P1 genotype and prognosis in Hodgkin's lymphoma. Clin Cancer Res. 2005 Mar 15; 11(6):2175-9. PMID: 15788664.
    View in: PubMed
  24. Milani R, Monni S, Di Ruscio A, Gulino M, Filogamo C, Spissu M, Di Franco S, Privitera L, Fantini A, Forteleoni G. [Proposed new variant of ureterosigmoidostomy. Theoretical principles and preliminary results]. Minerva Urol. 1981 Jul-Sep; 33(3):153-62. PMID: 7322108.
    View in: PubMed
  25. Milani R, Bianca T, Monni S, Di Franco S, Di Ruscio A, Filogamo C, Privitera L, Gulino M. [Basic theory and experimental results of a new method of approach to vascular hemodialysis (preliminary note)]. Chir Patol Sper. 1979 Aug; 27(4):319-34. PMID: 262635.
    View in: PubMed
  26. Sessa A, Cioffi A, Conte F, Conti U, Giordano F, Di Ruscio A, Vegeto A. End stage renal failure with syndrome of "malignant" hypertension in scleroderma. Report of a case treated by bilateral nephrectomy. Pathologica. 1976 Jul-Aug; 68(981-982):355-9. PMID: 1018990.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at For faculty personal and demographic information, contact HMS Office for Faculty Affairs at
Di Ruscio's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (174)
Co-Authors (14)
Similar People (60)
Same Department 
Physical Neighbors