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Annalisa Di Ruscio, Ph.D., M.D.

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2007 - 2008
2009 - 2012
T32 HL007917-11A1 Beth Israel Deaconess Medical Center, Boston, USA
2012 - 2013
Tito Bastianello fellowship

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00CA188595 (DI RUSCIO, ANNALISA) Jul 1, 2017 - Jun 30, 2021
    Determining the role of DNMT-interacting RNAs in myeloid disorders
    Role: Principal Investigator
  2. K99CA188595 (DI RUSCIO, ANNALISA) Jul 1, 2014 - Jun 30, 2017
    Determining the role of DNMT-interacting RNAs in myeloid disorders
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ummarino S, Hausman C, Gaggi G, Rinaldi L, Bassal MA, Zhang Y, Seelam AJ, Kobayashi IS, Borchiellini M, Ebralidze AK, Ghinassi B, Trinh BQ, Kobayashi SS, Di Ruscio A. NAD Modulates DNA Methylation and Cell Differentiation. Cells. 2021 11 02; 10(11). PMID: 34831209; PMCID: PMC8616462.
    Citations: 1     Fields:    Translation:HumansCells
  2. van der Kouwe E, Heller G, Czibere A, Pulikkan JA, Agreiter C, Castilla LH, Delwel R, Di Ruscio A, Ebralidze AK, Forte M, Grebien F, Heyes E, Kazianka L, Klinger J, Kornauth C, Le T, Lind K, Barbosa IAM, Pemovska T, Pichler A, Schmolke AS, Schweicker CM, Sill H, Sperr WR, Spittler A, Surapally S, Trinh BQ, Valent P, Vanura K, Welner RS, Zuber J, Tenen DG, Staber PB. Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter. Blood. 2021 10 14; 138(15):1345-1358. PMID: 34010414.
    Citations: 2     Fields:    Translation:HumansCells
  3. Trinh BQ, Ummarino S, Zhang Y, Ebralidze AK, Bassal MA, Nguyen TM, Heller G, Coffey R, Tenen DE, van der Kouwe E, Fabiani E, Gurnari C, Wu CS, Angarica VE, Yang H, Chen S, Zhang H, Thurm AR, Marchi F, Levantini E, Staber PB, Zhang P, Voso MT, Pandolfi PP, Kobayashi SS, Chai L, Di Ruscio A, Tenen DG. Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML. Blood. 2021 10 14; 138(15):1331-1344. PMID: 33971010; PMCID: PMC8525335.
    Citations: 4     Fields:    Translation:HumansCells
  4. Kwon J, Liu YV, Gao C, Bassal MA, Jones AI, Yang J, Chen Z, Li Y, Yang H, Chen L, Di Ruscio A, Tay Y, Chai L, Tenen DG. Pseudogene-mediated DNA demethylation leads to oncogene activation. Sci Adv. 2021 Oct; 7(40):eabg1695. PMID: 34597139.
    Citations: 1     Fields:    
  5. Ummarino S, Hausman C, Di Ruscio A. The PARP Way to Epigenetic Changes. Genes (Basel). 2021 03 20; 12(3). PMID: 33804735.
    Citations: 5     Fields:    Translation:HumansCells
  6. Wanet A, Bassal MA, Patel SB, Marchi F, Mariani SA, Ahmed N, Zhang H, Borchiellini M, Chen S, Zhang J, Di Ruscio A, Miyake K, Tsai M, Paranjape A, Park SY, Karasuyama H, Schroeder T, Dzierzak E, Galli SJ, Tenen DG, Welner RS. E-cadherin is regulated by GATA-2 and marks the early commitment of mouse hematopoietic progenitors to the basophil and mast cell fates. Sci Immunol. 2021 02 05; 6(56). PMID: 33547048; PMCID: PMC8261706.
    Citations: 6     Fields:    Translation:AnimalsCells
  7. Canesin G, Di Ruscio A, Li M, Ummarino S, Hedblom A, Choudhury R, Krzyzanowska A, Csizmadia E, Palominos M, Stiehm A, Ebralidze A, Chen SY, Bassal MA, Zhao P, Tolosano E, Hurley L, Bjartell A, Tenen DG, Wegiel B. Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases. Cell Rep. 2020 09 22; 32(12):108181. PMID: 32966797.
    Citations: 10     Fields:    Translation:HumansCells
  8. Gaggi G, Di Credico A, Izzicupo P, Antonucci I, Crescioli C, Di Giacomo V, Di Ruscio A, Amabile G, Alviano F, Di Baldassarre A, Ghinassi B. Epigenetic Features of Human Perinatal Stem Cells Redefine Their Stemness Potential. Cells. 2020 05 24; 9(5). PMID: 32456308.
    Citations: 8     Fields:    Translation:HumansCells
  9. Tapella L, Soda T, Mapelli L, Bortolotto V, Bondi H, Ruffinatti FA, Dematteis G, Stevano A, Dionisi M, Ummarino S, Di Ruscio A, Distasi C, Grilli M, Genazzani AA, D'Angelo E, Moccia F, Lim D. Deletion of calcineurin from GFAP-expressing astrocytes impairs excitability of cerebellar and hippocampal neurons through astroglial Na+ /K+ ATPase. Glia. 2020 03; 68(3):543-560. PMID: 31626368.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Borchiellini M, Ummarino S, Di Ruscio A. The Bright and Dark Side of DNA Methylation: A Matter of Balance. Cells. 2019 10 12; 8(10). PMID: 31614870.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Tan HK, Wu CS, Li J, Tan ZH, Hoffman JR, Fry CJ, Yang H, Di Ruscio A, Tenen DG. DNMT3B shapes the mCA landscape and regulates mCG for promoter bivalency in human embryonic stem cells. Nucleic Acids Res. 2019 08 22; 47(14):7460-7475. PMID: 31219573.
    Citations: 5     Fields:    Translation:HumansCells
  12. Li M, Cascino P, Ummarino S, Di Ruscio A. Application of Induced Pluripotent Stem Cell Technology to the Study of Hematological Diseases. Cells. 2017 Mar 08; 6(1). PMID: 28282903.
    Citations: 4     Fields:    
  13. Di Ruscio A, Patti F, Welner RS, Tenen DG, Amabile G. Multiple sclerosis: getting personal with induced pluripotent stem cells. Cell Death Dis. 2016 Apr 14; 7:e2185. PMID: 27077801.
    Citations:    Fields:    
  14. D'Amico MA, Ghinassi B, Izzicupo P, Di Ruscio A, Di Baldassarre A. IL-6 Activates PI3K and PKC? Signaling and Determines Cardiac Differentiation in Rat Embryonic H9c2 Cells. J Cell Physiol. 2016 Mar; 231(3):576-86. PMID: 26205888.
    Citations: 13     Fields:    Translation:AnimalsCells
  15. Di Ruscio A, Welner RS, Tenen DG, Amabile G. The second hit of DNA methylation. Mol Cell Oncol. 2016 May; 3(3):e1093690. PMID: 27314082.
    Citations: 2     
  16. Di Ruscio A, Patti F, Welner RS, Tenen DG, Amabile G. Multiple sclerosis: getting personal with induced pluripotent stem cells. Cell Death Dis. 2015 Jul 09; 6:e1806. PMID: 26158512.
    Citations: 8     Fields:    Translation:HumansCells
  17. Amabile G, Di Ruscio A, Müller F, Welner RS, Yang H, Ebralidze AK, Zhang H, Levantini E, Qi L, Martinelli G, Brummelkamp T, Le Beau MM, Figueroa ME, Bock C, Tenen DG. Dissecting the role of aberrant DNA methylation in human leukaemia. Nat Commun. 2015 May 22; 6:7091. PMID: 25997600.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  18. Welner RS, Amabile G, Bararia D, Czibere A, Yang H, Zhang H, Pontes LL, Ye M, Levantini E, Di Ruscio A, Martinelli G, Tenen DG. Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells. Cancer Cell. 2015 May 11; 27(5):671-81. PMID: 25965572.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  19. Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG. The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. Blood. 2014 Oct 09; 124(15):2391-9. PMID: 25185713; PMCID: PMC4192750.
    Citations: 20     Fields:    Translation:AnimalsCells
  20. Focosi D, Amabile G, Di Ruscio A, Quaranta P, Tenen DG, Pistello M. Induced pluripotent stem cells in hematology: current and future applications. Blood Cancer J. 2014 May 09; 4:e211. PMID: 24813079.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  21. Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Di Ruscio A, Diruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG. Sox4 is a key oncogenic target in C/EBPa mutant acute myeloid leukemia. Cancer Cell. 2013 Nov 11; 24(5):575-88. PMID: 24183681; PMCID: PMC4038627.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  22. Di Ruscio A, Ebralidze AK, Benoukraf T, Amabile G, Goff LA, Terragni J, Figueroa ME, De Figueiredo Pontes LL, Alberich-Jorda M, Zhang P, Wu M, D'Alò F, Melnick A, Leone G, Ebralidze KK, Pradhan S, Rinn JL, Tenen DG. DNMT1-interacting RNAs block gene-specific DNA methylation. Nature. 2013 Nov 21; 503(7476):371-6. PMID: 24107992.
    Citations: 235     Fields:    Translation:HumansCells
  23. Amabile G, Welner RS, Nombela-Arrieta C, D'Alise AM, Di Ruscio A, Ebralidze AK, Kraytsberg Y, Ye M, Kocher O, Neuberg DS, Khrapko K, Silberstein LE, Tenen DG. In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. Blood. 2013 Feb 21; 121(8):1255-64. PMID: 23212524; PMCID: PMC3701251.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  24. Alberich-Jordà M, Wouters B, Balastik M, Shapiro-Koss C, Zhang H, Di Ruscio A, DiRuscio A, Radomska HS, Ebralidze AK, Amabile G, Ye M, Zhang J, Lowers I, Avellino R, Melnick A, Figueroa ME, Valk PJ, Delwel R, Tenen DG. C/EBP? deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest. 2012 Dec; 122(12):4490-504. PMID: 23160200; PMCID: PMC3533560.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  25. Giachelia M, D'Alò F, Fabiani E, Saulnier N, Di Ruscio A, Guidi F, Hohaus S, Voso MT, Leone G. Gene expression profiling of myelodysplastic CD34+ hematopoietic stem cells treated in vitro with decitabine. Leuk Res. 2011 Apr; 35(4):465-71. PMID: 20869114.
    Citations: 2     Fields:    Translation:HumansCells
  26. Greco M, D'Alò F, Scardocci A, Criscuolo M, Fabiani E, Guidi F, Di Ruscio A, Migliara G, Pagano L, Fianchi L, Chiusolo P, Hohaus S, Leone G, Voso MT. Promoter methylation of DAPK1, E-cadherin and thrombospondin-1 in de novo and therapy-related myeloid neoplasms. Blood Cells Mol Dis. 2010 Oct 15; 45(3):181-5. PMID: 20655775.
    Citations: 15     Fields:    Translation:HumansCells
  27. O'Brien KB, Alberich-Jordà M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010 Jul; 137(13):2147-56. PMID: 20530543.
    Citations: 33     Fields:    Translation:AnimalsCells
  28. Guibal FC, Alberich-Jorda M, Hirai H, Ebralidze A, Levantini E, Di Ruscio A, Zhang P, Santana-Lemos BA, Neuberg D, Wagers AJ, Rego EM, Tenen DG. Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia. Blood. 2009 Dec 24; 114(27):5415-25. PMID: 19797526; PMCID: PMC2798860.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  29. Fabiani E, D'Alò F, Scardocci A, Greco M, Di Ruscio A, Criscuolo M, Fianchi L, Pagano L, Hohaus S, Leone G, Voso MT. Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes. Leuk Res. 2009 Aug; 33(8):1068-71. PMID: 19027952.
    Citations: 8     Fields:    Translation:HumansCells
  30. D'Alò F, Di Ruscio A, Guidi F, Fabiani E, Greco M, Rumi C, Hohaus S, Voso MT, Leone G. PU.1 and CEBPA expression in acute myeloid leukemia. Leuk Res. 2008 Sep; 32(9):1448-53. PMID: 18308386.
    Citations: 7     Fields:    Translation:Humans
  31. Voso MT, Fabiani E, D'Alo' F, Guidi F, Di Ruscio A, Sica S, Pagano L, Greco M, Hohaus S, Leone G. Increased risk of acute myeloid leukaemia due to polymorphisms in detoxification and DNA repair enzymes. Ann Oncol. 2007 Sep; 18(9):1523-8. PMID: 17761709.
    Citations: 27     Fields:    Translation:Humans
  32. Koschmieder S, D'Alò F, Radomska H, Schöneich C, Chang JS, Konopleva M, Kobayashi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R, Sargin B, Kantarjian H, Andreeff M, Sporn MB, Perrotti D, Berdel WE, Müller-Tidow C, Serve H, Tenen DG. CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha. Blood. 2007 Nov 15; 110(10):3695-705. PMID: 17671235; PMCID: PMC2077317.
    Citations: 30     Fields:    Translation:HumansCellsCTClinical Trials
  33. Scardocci A, Guidi F, D'Alo' F, Gumiero D, Fabiani E, Diruscio A, Martini M, Larocca LM, Zollino M, Hohaus S, Leone G, Voso MT. Reduced BRCA1 expression due to promoter hypermethylation in therapy-related acute myeloid leukaemia. Br J Cancer. 2006 Oct 23; 95(8):1108-13. PMID: 17047656; PMCID: PMC2360697.
    Citations: 33     Fields:    Translation:HumansCells
  34. Hohaus S, Di Ruscio A, Di Febo A, Massini G, D'Alo' F, Guidi F, Mansueto G, Voso MT, Leone G. Glutathione S-transferase P1 genotype and prognosis in Hodgkin's lymphoma. Clin Cancer Res. 2005 Mar 15; 11(6):2175-9. PMID: 15788664.
    Citations: 27     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.