Harvard Catalyst Profiles

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Douglas B. Cowan, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 12GRNT11910008 (COWAN, DOUGLAS B.) Jul 1, 2012 - Jun 30, 2016
    Characterization of Cardiac Progenitor Cells from Adult Skeletal Muscle
    Role: Principal Investigator
  2. Grant's Gala, Jasper Johnson Memorial Fund (COWAN, DOUGLAS B.) Jan 1, 2012 - Dec 31, 2015
    Development of a Cell-based Therapy for Congenital Complete Heart Block
    Role: Principal Investigator
  3. R01HL088206 (COWAN, DOUGLAS B.) Jul 18, 2007 - Jun 30, 2013
    Expansion and Directed Differentiation of Adult Side Population Stem Cells
    Role: Principal Investigator
  4. R01HL068915 (COWAN, DOUGLAS B.) Jan 18, 2002 - May 31, 2011
    Cardiac Conduction through Engineered Tissue
    Role: Principal Investigator
  5. Child Health Research Grant (Douglas B. Cowan) Jul 1, 2000 - Jun 30, 2002
    Charles H. Hood Foundation
    Endotoxin-Induced Cardiac Signal Transduction
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dong Y, Wang B, Du M, Zhu B, Cui K, Li K, Yuan K, Cowan DB, Bhattacharjee S, Wong S, Shi J, Wang DZ, Chen K, Bischoff J, Linton MF, Chen H. Targeting Epsins to Inhibit Fibroblast Growth Factor Signaling While Potentiating Transforming Growth Factor-ß Signaling Constrains Endothelial-to-Mesenchymal Transition in Atherosclerosis. Circulation. 2023 Jan 02. PMID: 36591786.
    Citations:    Fields:    
  2. Liu X, Cui K, Wu H, Li KS, Peng Q, Wang D, Cowan DB, Dixon JB, Sathish Srinivasan R, Bielenberg DR, Chen K, Wang DZ, Chen Y, Chen H. Promoting Lymphangiogenesis and Lymphatic Growth and Remodeling to Treat Cardiovascular and Metabolic Diseases. Arterioscler Thromb Vasc Biol. 2023 Jan; 43(1):e1-e10. PMID: 36453280; PMCID: PMC9780193.
    Citations:    Fields:    Translation:Humans
  3. Cui K, Gao X, Wang B, Wu H, Arulsamy K, Dong Y, Xiao Y, Jiang X, Malovichko MV, Li K, Peng Q, Lu YW, Zhu B, Zheng R, Wong S, Cowan DB, Linton M, Srivastava S, Shi J, Chen K, Chen H. Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression. Circ Res. 2023 Jan 06; 132(1):e22-e42. PMID: 36444722; PMCID: PMC9822875.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Singh B, Li K, Cui K, Peng Q, Cowan DB, Wang DZ, Chen K, Chen H. Defective efferocytosis of vascular cells in heart disease. Front Cardiovasc Med. 2022; 9:1031293. PMID: 36247464; PMCID: PMC9561431.
  5. Wu H, Norton V, Cui K, Zhu B, Bhattacharjee S, Lu YW, Wang B, Shan D, Wong S, Dong Y, Chan SL, Cowan D, Xu J, Bielenberg DR, Zhou C, Chen H. Diabetes and Its Cardiovascular Complications: Comprehensive Network and Systematic Analyses. Front Cardiovasc Med. 2022; 9:841928. PMID: 35252405; PMCID: PMC8891533.
  6. Liu N, Kataoka M, Wang Y, Pu L, Dong X, Fu X, Zhang F, Gao F, Liang T, Pei J, Xiao C, Qiu Q, Hong T, Chen Q, Zhao J, Zhu L, He J, Hu X, Nie Y, Zhu W, Yu H, Cowan DB, Hu X, Wang J, Wang DZ, Chen J. LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway. Basic Res Cardiol. 2021 08 11; 116(1):48. PMID: 34379189; PMCID: PMC8357683.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  7. Dong Y, Wang B, Cui K, Cai X, Bhattacharjee S, Wong S, Cowan DB, Chen H. Epsins Negatively Regulate Aortic Endothelial Cell Function by Augmenting Inflammatory Signaling. Cells. 2021 07 29; 10(8). PMID: 34440686; PMCID: PMC8391889.
    Citations:    Fields:    Translation:AnimalsCells
  8. Wang Y, Chen J, Cowan DB, Wang DZ. Non-coding RNAs in cardiac regeneration: Mechanism of action and therapeutic potential. Semin Cell Dev Biol. 2021 10; 118:150-162. PMID: 34284952; PMCID: PMC8434979.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Seok H, Deng R, Cowan DB, Wang DZ. Application of CRISPR-Cas9 gene editing for congenital heart disease. Clin Exp Pediatr. 2021 Jun; 64(6):269-279. PMID: 33677855.
    Citations: 1     
  10. Cui K, Dong Y, Wang B, Cowan DB, Chan SL, Shyy J, Chen H. Endocytic Adaptors in Cardiovascular Disease. Front Cell Dev Biol. 2020; 8:624159. PMID: 33363178; PMCID: PMC7759532.
    Citations: 1     
  11. Liang T, Gao F, Jiang J, Lu YW, Zhang F, Wang Y, Liu N, Fu X, Dong X, Pei J, Cowan DB, Hu X, Wang J, Wang DZ, Chen J. Loss of Phosphatase and Tensin Homolog Promotes Cardiomyocyte Proliferation and Cardiac Repair After Myocardial Infarction. Circulation. 2020 12; 142(22):2196-2199. PMID: 33253002; PMCID: PMC7853321.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Zhang F, Fu X, Kataoka M, Liu N, Wang Y, Gao F, Liang T, Dong X, Pei J, Hu X, Zhu W, Yu H, Cowan DB, Hu X, Huang ZP, Wang J, Wang DZ, Chen J. Long noncoding RNA Cfast regulates cardiac fibrosis. Mol Ther Nucleic Acids. 2021 Mar 05; 23:377-392. PMID: 33473324; PMCID: PMC7787992.
    Citations: 6     
  13. Singh GB, Cowan DB, Wang DZ. Tiny Regulators of Massive Tissue: MicroRNAs in Skeletal Muscle Development, Myopathies, and Cancer Cachexia. Front Oncol. 2020; 10:598964. PMID: 33330096; PMCID: PMC7719840.
    Citations: 6     
  14. Cao J, Cowan DB, Wang DZ. tRNA-Derived Small RNAs and Their Potential Roles in Cardiac Hypertrophy. Front Pharmacol. 2020; 11:572941. PMID: 33041815; PMCID: PMC7527594.
    Citations: 8     
  15. Guo H, Lu YW, Lin Z, Huang ZP, Liu J, Wang Y, Seok HY, Hu X, Ma Q, Li K, Kyselovic J, Wang Q, Lin JL, Lin JJ, Cowan DB, Naya F, Chen Y, Pu WT, Wang DZ. Intercalated disc protein Xinß is required for Hippo-YAP signaling in the heart. Nat Commun. 2020 09 16; 11(1):4666. PMID: 32938943; PMCID: PMC7494909.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Weixler V, Lapusca R, Grangl G, Guariento A, Saeed MY, Cowan DB, Del Nido PJ, McCully JD, Friehs I. Autogenous mitochondria transplantation for treatment of right heart failure. J Thorac Cardiovasc Surg. 2021 07; 162(1):e111-e121. PMID: 32919774.
    Citations: 8     Fields:    Translation:AnimalsCells
  17. Dong Y, Lee Y, Cui K, He M, Wang B, Bhattacharjee S, Zhu B, Yago T, Zhang K, Deng L, Ouyang K, Wen A, Cowan DB, Song K, Yu L, Brophy ML, Liu X, Wylie-Sears J, Wu H, Wong S, Cui G, Kawashima Y, Matsumoto H, Kodera Y, Wojcikiewicz RJH, Srivastava S, Bischoff J, Wang DZ, Ley K, Chen H. Epsin-mediated degradation of IP3R1 fuels atherosclerosis. Nat Commun. 2020 08 07; 11(1):3984. PMID: 32770009.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Bektik E, Cowan DB, Wang DZ. Long Non-Coding RNAs in Atrial Fibrillation: Pluripotent Stem Cell-Derived Cardiomyocytes as a Model System. Int J Mol Sci. 2020 Jul 30; 21(15). PMID: 32751460.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  19. Shin B, Saeed MY, Esch JJ, Guariento A, Blitzer D, Moskowitzova K, Ramirez-Barbieri G, Orfany A, Thedsanamoorthy JK, Cowan DB, Inkster JA, Snay ER, Staffa SJ, Packard AB, Zurakowski D, Del Nido PJ, McCully JD. A Novel Biological Strategy for Myocardial Protection by Intracoronary Delivery of Mitochondria: Safety and Efficacy. JACC Basic Transl Sci. 2019 Dec; 4(8):871-888. PMID: 31909298; PMCID: PMC6938990.
    Citations: 22     
  20. Moskowitzova K, Orfany A, Liu K, Ramirez-Barbieri G, Thedsanamoorthy JK, Yao R, Guariento A, Doulamis IP, Blitzer D, Shin B, Snay ER, Inkster JAH, Iken K, Packard AB, Cowan DB, Visner GA, Del Nido PJ, McCully JD. Mitochondrial transplantation enhances murine lung viability and recovery after ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L78-L88. PMID: 31693391.
    Citations: 21     Fields:    Translation:AnimalsCells
  21. Zeriouh M, Sabashnikov A, Tenbrock A, Neef K, Merkle J, Eghbalzadeh K, Weber C, Liakopoulos OJ, Deppe AC, Stamm C, Cowan DB, Wahlers T, Choi YH. Dysregulation of proangiogeneic factors in pressure-overload left-ventricular hypertrophy results in inadequate capillary growth. Ther Adv Cardiovasc Dis. 2019 Jan-Dec; 13:1753944719841795. PMID: 31088231; PMCID: PMC6535753.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Moskowitzova K, Shin B, Liu K, Ramirez-Barbieri G, Guariento A, Blitzer D, Thedsanamoorthy JK, Yao R, Snay ER, Inkster JAH, Orfany A, Zurakowski D, Cowan DB, Packard AB, Visner GA, Del Nido PJ, McCully JD. Mitochondrial transplantation prolongs cold ischemia time in murine heart transplantation. J Heart Lung Transplant. 2019 01; 38(1):92-99. PMID: 30391192; PMCID: PMC6574228.
    Citations: 18     Fields:    Translation:AnimalsCells
  23. Cowan DB, Yao R, Thedsanamoorthy JK, Zurakowski D, Del Nido PJ, McCully JD. Transit and integration of extracellular mitochondria in human heart cells. Sci Rep. 2017 12 12; 7(1):17450. PMID: 29234096.
    Citations: 41     Fields:    Translation:HumansCells
  24. McCully JD, Cowan DB, Emani SM, Del Nido PJ. Mitochondrial transplantation: From animal models to clinical use in humans. Mitochondrion. 2017 05; 34:127-134. PMID: 28342934.
    Citations: 41     Fields:    Translation:AnimalsCells
  25. Shin B, Cowan DB, Emani SM, Del Nido PJ, McCully JD. Mitochondrial Transplantation in Myocardial Ischemia and Reperfusion Injury. Adv Exp Med Biol. 2017; 982:595-619. PMID: 28551809.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  26. Kaza AK, Wamala I, Friehs I, Kuebler JD, Rathod RH, Berra I, Ericsson M, Yao R, Thedsanamoorthy JK, Zurakowski D, Levitsky S, Del Nido PJ, Cowan DB, McCully JD. Myocardial rescue with autologous mitochondrial transplantation in a porcine model of ischemia/reperfusion. J Thorac Cardiovasc Surg. 2017 04; 153(4):934-943. PMID: 27938904.
    Citations: 47     Fields:    Translation:AnimalsCells
  27. Cowan DB, Yao R, Akurathi V, Snay ER, Thedsanamoorthy JK, Zurakowski D, Ericsson M, Friehs I, Wu Y, Levitsky S, Del Nido PJ, Packard AB, McCully JD. Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection. PLoS One. 2016; 11(8):e0160889. PMID: 27500955.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  28. McCully JD, Levitsky S, Del Nido PJ, Cowan DB. Mitochondrial transplantation for therapeutic use. Clin Transl Med. 2016 Mar; 5(1):16. PMID: 27130633; PMCID: PMC4851669.
    Citations: 46     Fields:    
  29. Neef K, Treskes P, Xu G, Drey F, Srinivasan SP, Saric T, Nembo E, Semmler J, Nguemo F, Stamm C, Cowan DB, Deppe AC, Scherner M, Wittwer T, Hescheler J, Wahlers T, Choi YH. Dynamic Support Culture of Murine Skeletal Muscle-Derived Stem Cells Improves Their Cardiogenic Potential In Vitro. Stem Cells Int. 2015; 2015:247091. PMID: 26357517; PMCID: PMC4556334.
  30. Bartholomä MD, Zhang S, Akurathi V, Pacak CA, Dunning P, Fahey FH, Cowan DB, Treves ST, Packard AB. (18)F-labeled rhodamines as potential myocardial perfusion agents: comparison of pharmacokinetic properties of several rhodamines. Nucl Med Biol. 2015 Oct; 42(10):796-803. PMID: 26205075; PMCID: PMC4567415.
    Citations: 10     Fields:    Translation:AnimalsCells
  31. Pacak CA, Preble JM, Kondo H, Seibel P, Levitsky S, Del Nido PJ, Cowan DB, McCully JD. Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function. Biol Open. 2015 Apr 10; 4(5):622-6. PMID: 25862247.
    Citations: 56     Fields:    
  32. Pacak CA, Hammer PE, MacKay AA, Dowd RP, Wang KR, Masuzawa A, Sill B, McCully JD, Cowan DB. Superparamagnetic iron oxide nanoparticles function as a long-term, multi-modal imaging label for non-invasive tracking of implanted progenitor cells. PLoS One. 2014; 9(9):e108695. PMID: 25250622.
    Citations: 7     Fields:    Translation:AnimalsCells
  33. Treskes P, Neef K, Perumal Srinivasan S, Halbach M, Stamm C, Cowan D, Scherner M, Madershahian N, Wittwer T, Hescheler J, Wahlers T, Choi YH. Preconditioning of skeletal myoblast-based engineered tissue constructs enables functional coupling to myocardium in vivo. J Thorac Cardiovasc Surg. 2015 Jan; 149(1):348-56. PMID: 25439779; PMCID: PMC4476636.
    Citations: 4     Fields:    Translation:AnimalsCells
  34. Preble JM, Pacak CA, Kondo H, MacKay AA, Cowan DB, McCully JD. Rapid isolation and purification of mitochondria for transplantation by tissue dissociation and differential filtration. J Vis Exp. 2014 Sep 06; (91):e51682. PMID: 25225817.
    Citations: 27     Fields:    Translation:Cells
  35. Pacak CA, MacKay AA, Cowan DB. An improved method for the preparation of type I collagen from skin. J Vis Exp. 2014 Jan 21; (83):e51011. PMID: 24473107.
    Citations: 8     Fields:    Translation:HumansAnimals
  36. Pacak CA, Cowan DB. Growth of bone marrow and skeletal muscle side population stem cells in suspension culture. Methods Mol Biol. 2014; 1210:51-61. PMID: 25173160.
    Citations: 2     Fields:    Translation:AnimalsCells
  37. Bartholomä MD, He H, Pacak CA, Dunning P, Fahey FH, McGowan FX, Cowan DB, Treves ST, Packard AB. Biological characterization of F-18-labeled rhodamine B, a potential positron emission tomography perfusion tracer. Nucl Med Biol. 2013 Nov; 40(8):1043-8. PMID: 24011396.
    Citations: 4     Fields:    Translation:AnimalsCells
  38. Pacak CA, Eddy MT, Woodhull L, Wang KR, Alpatov I, Fullen S, Dowd RP, Choi YH, Cowan DB. Microcarrier-based expansion of adult murine side population stem cells. PLoS One. 2013; 8(1):e55187. PMID: 23383102.
    Citations: 4     Fields:    Translation:AnimalsCells
  39. Masuzawa A, Black KM, Pacak CA, Ericsson M, Barnett RJ, Drumm C, Seth P, Bloch DB, Levitsky S, Cowan DB, McCully JD. Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2013 Apr 01; 304(7):H966-82. PMID: 23355340.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  40. Friehs I, Cowan DB, Choi YH, Black KM, Barnett R, Bhasin MK, Daly C, Dillon SJ, Libermann TA, McGowan FX, del Nido PJ, Levitsky S, McCully JD. Pressure-overload hypertrophy of the developing heart reveals activation of divergent gene and protein pathways in the left and right ventricular myocardium. Am J Physiol Heart Circ Physiol. 2013 Mar 01; 304(5):H697-708. PMID: 23262132.
    Citations: 11     Fields:    Translation:AnimalsCells
  41. Neef K, Choi YH, Srinivasan SP, Treskes P, Cowan DB, Stamm C, Rubach M, Adelmann R, Wittwer T, Wahlers T. Mechanical preconditioning enables electrophysiologic coupling of skeletal myoblast cells to myocardium. J Thorac Cardiovasc Surg. 2012 Nov; 144(5):1176-1184.e1. PMID: 22980065; PMCID: PMC4334564.
    Citations: 5     Fields:    Translation:AnimalsCells
  42. Srinivasan SP, Neef K, Treskes P, Liakopoulos OJ, Stamm C, Cowan DB, Madershahian N, Kuhn E, Slottosch I, Wittwer T, Wahlers T, Choi YH. Enhanced gap junction expression in myoblast-containing engineered tissue. Biochem Biophys Res Commun. 2012 Jun 08; 422(3):462-468. PMID: 22579687.
    Citations: 7     Fields:    Translation:AnimalsCells
  43. Pacak CA, Powers JM, Cowan DB. Ultrarapid purification of collagen type I for tissue engineering applications. Tissue Eng Part C Methods. 2011 Sep; 17(9):879-85. PMID: 21486201.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  44. Sill B, Roy N, Hammer PE, Triedman JK, Sigg DC, Kelly MF, Nedder A, Dunning PS, Cowan DB. Development of an ovine model of pediatric complete heart block. J Surg Res. 2011 Apr; 166(2):e103-8. PMID: 21227467.
    Citations: 3     Fields:    Translation:Animals
  45. Wolf CM, Seslar SP, den Boer K, Juraszek AL, McGowan FX, Cowan DB, Del Nido P, Triedman JK, Berul CI, Walsh EP. Atrial remodeling after the Fontan operation. Am J Cardiol. 2009 Dec 15; 104(12):1737-42. PMID: 19962486; PMCID: PMC3399422.
    Citations: 8     Fields:    Translation:Humans
  46. Kitahori K, He H, Kawata M, Cowan DB, Friehs I, Del Nido PJ, McGowan FX. Development of left ventricular diastolic dysfunction with preservation of ejection fraction during progression of infant right ventricular hypertrophy. Circ Heart Fail. 2009 Nov; 2(6):599-607. PMID: 19919985.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  47. Sill B, Hammer PE, Cowan DB. Optical mapping of Langendorff-perfused rat hearts. J Vis Exp. 2009 Aug 11; (30). PMID: 19684567.
    Citations: 5     Fields:    Translation:Animals
  48. Toumpoulis IK, Oxford JT, Cowan DB, Anagnostopoulos CE, Rokkas CK, Chamogeorgakis TP, Angouras DC, Shemin RJ, Navab M, Ericsson M, Federman M, Levitsky S, McCully JD. Differential expression of collagen type V and XI alpha-1 in human ascending thoracic aortic aneurysms. Ann Thorac Surg. 2009 Aug; 88(2):506-13. PMID: 19632402; PMCID: PMC2834780.
    Citations: 10     Fields:    Translation:HumansCells
  49. Choi YH, Cowan DB, Wahlers TC, Hetzer R, Del Nido PJ, Stamm C. Calcium sensitisation impairs diastolic relaxation in post-ischaemic myocardium: implications for the use of Ca(2+) sensitising inotropes after cardiac surgery. Eur J Cardiothorac Surg. 2010 Feb; 37(2):376-83. PMID: 19616444.
    Citations: 7     Fields:    Translation:AnimalsCells
  50. Sill B, Alpatov IV, Pacak CA, Cowan DB. Implantation of engineered tissue in the rat heart. J Vis Exp. 2009 Jun 24; (28). PMID: 19553905.
    Citations: 3     Fields:    Translation:AnimalsCells
  51. McCully JD, Bhasin MK, Daly C, Guerrero MC, Dillon S, Liberman TA, Cowan DB, Mably JD, McGowan FX, Levitsky S. Transcriptomic and proteomic analysis of global ischemia and cardioprotection in the rabbit heart. Physiol Genomics. 2009 Jul 09; 38(2):125-37. PMID: 19454556.
    Citations: 12     Fields:    Translation:AnimalsCells
  52. Pacak CA, Cowan DB. Fabrication of myogenic engineered tissue constructs. J Vis Exp. 2009 May 01; (27). PMID: 19412158.
    Citations: 4     Fields:    Translation:AnimalsCells
  53. Choi YH, Cowan DB, Moran AM, Colan SD, Stamm C, Takeuchi K, Friehs I, del Nido PJ, McGowan FX. Myocyte apoptosis occurs early during the development of pressure-overload hypertrophy in infant myocardium. J Thorac Cardiovasc Surg. 2009 Jun; 137(6):1356-62, 1362.e1-3. PMID: 19464448; PMCID: PMC2758562.
    Citations: 9     Fields:    Translation:AnimalsCells
  54. Choi YH, Cowan DB, Nathan M, Poutias D, Stamm C, del Nido PJ, McGowan FX. Myocardial hypertrophy overrides the angiogenic response to hypoxia. PLoS One. 2008; 3(12):e4042. PMID: 19112498.
    Citations: 10     Fields:    Translation:Animals
  55. McCully JD, Cowan DB, Pacak CA, Toumpoulis IK, Dayalan H, Levitsky S. Injection of isolated mitochondria during early reperfusion for cardioprotection. Am J Physiol Heart Circ Physiol. 2009 Jan; 296(1):H94-H105. PMID: 18978192; PMCID: PMC2637784.
    Citations: 63     Fields:    Translation:AnimalsCells
  56. Roy N, Friehs I, Cowan DB, Zurakowski D, McGowan FX, del Nido PJ. Dopamine induces postischemic cardiomyocyte apoptosis in vivo: an effect ameliorated by propofol. Ann Thorac Surg. 2006 Dec; 82(6):2192-9. PMID: 17126134.
    Citations: 7     Fields:    Translation:AnimalsCells
  57. Yoon S, Molloy MJ, Wu MP, Cowan DB, Gussoni E. C6ORF32 is upregulated during muscle cell differentiation and induces the formation of cellular filopodia. Dev Biol. 2007 Jan 01; 301(1):70-81. PMID: 17150207.
    Citations: 22     Fields:    Translation:HumansCells
  58. Tansey EE, Kwaku KF, Hammer PE, Cowan DB, Federman M, Levitsky S, McCully JD. Reduction and redistribution of gap and adherens junction proteins after ischemia and reperfusion. Ann Thorac Surg. 2006 Oct; 82(4):1472-9. PMID: 16996956; PMCID: PMC1805692.
    Citations: 26     Fields:    Translation:AnimalsCells
  59. Cowan DB, McGowan FX. A paradigm shift in cardiac pacing therapy? Circulation. 2006 Sep 05; 114(10):986-8. PMID: 16952993; PMCID: PMC1570537.
    Citations: 1     Fields:    Translation:HumansAnimals
  60. Choi YH, Stamm C, Hammer PE, Kwaku KF, Marler JJ, Friehs I, Jones M, Rader CM, Roy N, Eddy MT, Triedman JK, Walsh EP, McGowan FX, del Nido PJ, Cowan DB. Cardiac conduction through engineered tissue. Am J Pathol. 2006 Jul; 169(1):72-85. PMID: 16816362; PMCID: PMC1534117.
    Citations: 27     Fields:    Translation:AnimalsCells
  61. Luxameechanporn T, Hadlock T, Shyu J, Cowan D, Faquin W, Varvares M. Successful myoblast transplantation in rat tongue reconstruction. Head Neck. 2006 Jun; 28(6):517-24. PMID: 16619280.
    Citations: 4     Fields:    Translation:AnimalsCells
  62. Bayliss PE, Bellavance KL, Whitehead GG, Abrams JM, Aegerter S, Robbins HS, Cowan DB, Keating MT, O'Reilly T, Wood JM, Roberts TM, Chan J. Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nat Chem Biol. 2006 May; 2(5):265-73. PMID: 16565716; PMCID: PMC1534118.
    Citations: 46     Fields:    Translation:AnimalsCells
  63. Chen JN, Cowan DB, Mably JD. Cardiogenesis and the regulation of cardiac-specific gene expression. Heart Fail Clin. 2005 Jul; 1(2):157-70. PMID: 17386843.
    Citations: 1     Fields:    Translation:HumansAnimals
  64. Nathan M, Friehs I, Choi YH, Cowan DB, Cao-Danh H, McGowan FX, del Nido PJ. Cyclosporin A but not FK-506 protects against dopamine-induced apoptosis in the stunned heart. Ann Thorac Surg. 2005 May; 79(5):1620-6. PMID: 15854943.
    Citations: 5     Fields:    Translation:Animals
  65. Friehs I, Moran AM, Stamm C, Choi YH, Cowan DB, McGowan FX, del Nido PJ. Promoting angiogenesis protects severely hypertrophied hearts from ischemic injury. Ann Thorac Surg. 2004 Jun; 77(6):2004-10; discussion 2011. PMID: 15172254.
    Citations: 25     Fields:    Translation:Animals
  66. Stamm C, Cowan DB. Endotoxemia and cardiac function. J Thorac Cardiovasc Surg. 2004 Jan; 127(1):305. PMID: 14752463.
    Citations:    Fields:    Translation:Humans
  67. Bunaprasert T, Hadlock T, Marler J, Kobler J, Cowan D, Faquin W, Varvares M. Tissue engineered muscle implantation for tongue reconstruction: a preliminary report. Laryngoscope. 2003 Oct; 113(10):1792-7. PMID: 14520108.
    Citations: 5     Fields:    Translation:AnimalsCells
  68. Cowan DB, Jones M, Garcia LM, Noria S, del Nido PJ, McGowan FX. Hypoxia and stretch regulate intercellular communication in vascular smooth muscle cells through reactive oxygen species formation. Arterioscler Thromb Vasc Biol. 2003 Oct 01; 23(10):1754-60. PMID: 12958040.
    Citations: 13     Fields:    Translation:AnimalsCells
  69. Friehs I, Cao-Danh H, Stamm C, Cowan DB, McGowan FX, del Nido PJ. Postnatal increase in insulin-sensitive glucose transporter expression is associated with improved recovery of postischemic myocardial function. J Thorac Cardiovasc Surg. 2003 Jul; 126(1):263-71. PMID: 12878964.
    Citations: 4     Fields:    Translation:Animals
  70. McCully JD, Wakiyama H, Cowan DB, Federman M, Parker RA, Levitsky S. Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery. Ann Thorac Surg. 2002 Dec; 74(6):2138-45; discussion 2146. PMID: 12643408; PMCID: PMC3668433.
    Citations: 12     Fields:    Translation:AnimalsCells
  71. Chanani NK, Cowan DB, Takeuchi K, Poutias DN, Garcia LM, del Nido PJ, McGowan FX. Differential effects of amrinone and milrinone upon myocardial inflammatory signaling. Circulation. 2002 Sep 24; 106(12 Suppl 1):I284-9. PMID: 12354747.
    Citations: 21     Fields:    Translation:AnimalsCells
  72. Stamm C, Friehs I, Cowan DB, Cao-Danh H, Choi YH, Duebener LF, McGowan FX, del Nido PJ. Dopamine treatment of postischemic contractile dysfunction rapidly induces calcium-dependent pro-apoptotic signaling. Circulation. 2002 Sep 24; 106(12 Suppl 1):I290-8. PMID: 12354748.
    Citations: 12     Fields:    Translation:AnimalsCells
  73. Munakata M, Stamm C, Friehs I, Zurakowski D, Cowan DB, Cao-Danh H, McGowan FX, del Nido PJ. Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C. Ann Thorac Surg. 2002 Apr; 73(4):1236-45. PMID: 11998814.
    Citations: 4     Fields:    Translation:AnimalsCells
  74. Wakiyama H, Cowan DB, Toyoda Y, Federman M, Levitsky S, McCully JD. Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis. Eur J Cardiothorac Surg. 2002 Mar; 21(3):424-33. PMID: 11888758; PMCID: PMC3711118.
    Citations: 12     Fields:    Translation:AnimalsCells
  75. Soriano SG, Cowan DB, Proctor MR, Scott RM. Levels of soluble adhesion molecules are elevated in the cerebrospinal fluid of children with moyamoya syndrome. Neurosurgery. 2002 Mar; 50(3):544-9. PMID: 11841722.
    Citations: 19     Fields:    Translation:Humans
  76. Merante F, Altamentova SM, Mickle DA, Weisel RD, Thatcher BJ, Martin BM, Marshall JG, Tumiati LC, Cowan DB, Li RK. The characterization and purification of a human transcription factor modulating the glutathione peroxidase gene in response to oxygen tension. Mol Cell Biochem. 2002 Jan; 229(1-2):73-83. PMID: 11936849.
    Citations: 6     Fields:    Translation:HumansCells
  77. Stamm C, Cowan DB, Friehs I, Noria S, del Nido PJ, McGowan FX. Rapid endotoxin-induced alterations in myocardial calcium handling: obligatory role of cardiac TNF-alpha. Anesthesiology. 2001 Dec; 95(6):1396-405. PMID: 11748398.
    Citations: 13     Fields:    Translation:AnimalsCells
  78. Stamm C, Friehs I, Cowan DB, Moran AM, Cao-Danh H, Duebener LF, del Nido PJ, McGowan FX. Inhibition of tumor necrosis factor-alpha improves postischemic recovery of hypertrophied hearts. Circulation. 2001 Sep 18; 104(12 Suppl 1):I350-5. PMID: 11568081.
    Citations: 23     Fields:    Translation:AnimalsCells
  79. Stamm C, Friehs I, Cowan DB, Cao-Danh H, Noria S, Munakata M, McGowan FX, del Nido PJ. Post-ischemic PKC inhibition impairs myocardial calcium handling and increases contractile protein calcium sensitivity. Cardiovasc Res. 2001 Jul; 51(1):108-21. PMID: 11399253.
    Citations: 6     Fields:    Translation:Animals
  80. Cowan DB, Noria S, Stamm C, Garcia LM, Poutias DN, del Nido PJ, McGowan FX. Lipopolysaccharide internalization activates endotoxin-dependent signal transduction in cardiomyocytes. Circ Res. 2001 Mar 16; 88(5):491-8. PMID: 11249872.
    Citations: 17     Fields:    Translation:AnimalsCells
  81. MacGowan GA, Du C, Cowan DB, Stamm C, McGowan FX, Solaro RJ, Koretsky AP, Del Nido PJ. Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites. Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H835-43. PMID: 11158984.
    Citations: 17     Fields:    Translation:AnimalsCells
  82. Takeuchi K, del Nido PJ, Poutias DN, Cowan DB, Munakata M, McGowan FX. Vesnarinone restores contractility and calcium handling in early endotoxemia. Circulation. 2000 Nov 07; 102(19 Suppl 3):III365-9. PMID: 11082415.
    Citations: 2     Fields:    Translation:AnimalsCells
  83. Cowan DB, Poutias DN, Del Nido PJ, McGowan FX. CD14-independent activation of cardiomyocyte signal transduction by bacterial endotoxin. Am J Physiol Heart Circ Physiol. 2000 Aug; 279(2):H619-29. PMID: 10924061.
    Citations: 9     Fields:    Translation:AnimalsCells
  84. Noria S, Cowan DB, Gotlieb AI, Langille BL. Transient and steady-state effects of shear stress on endothelial cell adherens junctions. Circ Res. 1999 Sep 17; 85(6):504-14. PMID: 10488053.
    Citations: 68     Fields:    Translation:AnimalsCells
  85. Takeuchi K, del Nido PJ, Ibrahim AE, Poutias DN, Glynn P, Cao-Danh H, Cowan DB, McGowan FX. Increased myocardial calcium cycling and reduced myofilament calcium sensitivity in early endotoxemia. Surgery. 1999 Aug; 126(2):231-8. PMID: 10455889.
    Citations: 5     Fields:    Translation:AnimalsCells
  86. Takeuchi K, del Nido PJ, Ibrahim AE, Cao-Danh H, Friehs I, Glynn P, Poutias D, Cowan DB, McGowan FX. Vesnarinone and amrinone reduce the systemic inflammatory response syndrome. J Thorac Cardiovasc Surg. 1999 Feb; 117(2):375-82. PMID: 9918980.
    Citations: 3     Fields:    Translation:AnimalsCells
  87. Cowan DB, Lye SJ, Langille BL. Regulation of vascular connexin43 gene expression by mechanical loads. Circ Res. 1998 Apr 20; 82(7):786-93. PMID: 9562438.
    Citations: 30     Fields:    Translation:AnimalsCells
  88. Cowan DB, Langille BL. Cellular and molecular biology of vascular remodeling. Curr Opin Lipidol. 1996 Apr; 7(2):94-100. PMID: 8743902.
    Citations: 14     Fields:    Translation:HumansAnimals
  89. Li RK, Cowan DB, Mickle DA, Weisel RD, Burton GW. Effect of vitamin E on human glutathione peroxidase (GSH-PX1) expression in cardiomyocytes. Free Radic Biol Med. 1996; 21(4):419-26. PMID: 8886791.
    Citations: 3     Fields:    Translation:HumansCells
  90. Cowan DB, Weisel RD, Williams WG, Mickle DA. Identification of oxygen responsive elements in the 5'-flanking region of the human glutathione peroxidase gene. J Biol Chem. 1993 Dec 25; 268(36):26904-10. PMID: 8262924.
    Citations: 22     Fields:    Translation:HumansCells
  91. Cowan DB, Weisel RD, Williams WG, Mickle DA. The regulation of glutathione peroxidase gene expression by oxygen tension in cultured human cardiomyocytes. J Mol Cell Cardiol. 1992 Apr; 24(4):423-33. PMID: 1535667.
    Citations: 9     Fields:    Translation:HumansCells
  92. Cowan DB, Chaban G, Liew CC. The DNA-binding properties of a rat nuclear phosphoprotein. Biochem J. 1991 Mar 15; 274 ( Pt 3):687-91. PMID: 2012598; PMCID: PMC1149966.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.