Harvard Catalyst Profiles

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Sungwhan Oh, Ph.D.


Seoul National University, Seoul, KoreaB.S.08/2003Chemistry
Harvard Medical School, Boston, MAPh.D.06/2009Biological Chemistry/Molecular Pharmacology


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI165987 (OH, SUNGWHAN F) Jun 14, 2022 - May 31, 2027
    Gut symbiotic microbiota-derived CD1d ligands and their immunomodulatory mechanisms
    Role Description: This R01 award supports PI’s 5-year project, addressing molecular mechanisms of gut symbiont-derived CD1d ligands.
    Role: PI
  2. W81XWH1910626 (OH, SUNGWHAN F) Sep 29, 2019 - Dec 29, 2022
    Department of Defense
    Gut Symbiotic Lipid A Family: Structures and Immunomodulation in IBD
    Role Description: This award supports a 3-year, Multi-PI project (joint PI: Dr. Dennis Kasper at Harvard Medical School), investigating structural and chemical variety of lipid A molecules originated from gut symbiotic microbial species.
    Role: PI
  3. R01AT010268 (OH, SUNGWHAN F) Feb 1, 2019 - Jan 31, 2023
    Contribution of phytochemicals to gut symbiont colonization and synthesis of immunomodulatory sphingolipids
    Role Description: This R01 award supports PI’s 4-year project, addressing interaction of dietary phytochemicals and probiotic bacterial species and their immunomodulatory impact to the host by production of immunomodulatory sphingolipids.
    Role: PI

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Brüggemann TR, Carlo T, Krishnamoorthy N, Duvall MG, Abdulnour RE, Nijmeh J, Peh HY, Filippakis H, Croze RH, Goh B, Oh SF, Levy BD. Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization. iScience. 2022 Oct 21; 25(10):105185. PMID: 36238896; PMCID: PMC9550614.
  2. Oh SF, Jung DJ, Choi E. Gut Microbiota-Derived Unconventional T Cell Ligands: Contribution to Host Immune Modulation. Immunohorizons. 2022 07 22; 6(7):476-487. PMID: 35868838.
    Citations:    Fields:    
  3. Oh SF, Praveena T, Song H, Yoo JS, Jung DJ, Erturk-Hasdemir D, Hwang YS, Lee CC, Le Nours J, Kim H, Lee J, Blumberg RS, Rossjohn J, Park SB, Kasper DL. Host immunomodulatory lipids created by symbionts from dietary amino acids. Nature. 2021 12; 600(7888):302-307. PMID: 34759313; PMCID: PMC8999822.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  4. Rajan S, Jang Y, Kim CH, Kim W, Toh HT, Jeon J, Song B, Serra A, Lescar J, Yoo JY, Beldar S, Ye H, Kang C, Liu XW, Feitosa M, Kim Y, Hwang D, Goh G, Lim KL, Park HM, Lee CH, Oh SF, Petsko GA, Yoon HS, Kim KS. PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function. Nat Chem Biol. 2020 08; 16(8):876-886. PMID: 32451509; PMCID: PMC7405943.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  5. Zheng W, Zhao W, Wu M, Song X, Caro F, Sun X, Gazzaniga F, Stefanetti G, Oh S, Mekalanos JJ, Kasper DL. Microbiota-targeted maternal antibodies protect neonates from enteric infection. Nature. 2020 01; 577(7791):543-548. PMID: 31915378; PMCID: PMC7362890.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  6. Song X, Sun X, Oh SF, Wu M, Zhang Y, Zheng W, Geva-Zatorsky N, Jupp R, Mathis D, Benoist C, Kasper DL. Microbial bile acid metabolites modulate gut ROR?+ regulatory T cell homeostasis. Nature. 2020 01; 577(7790):410-415. PMID: 31875848; PMCID: PMC7274525.
    Citations: 189     Fields:    Translation:AnimalsCells
  7. Erturk-Hasdemir D, Oh SF, Okan NA, Stefanetti G, Gazzaniga FS, Seeberger PH, Plevy SE, Kasper DL. Symbionts exploit complex signaling to educate the immune system. Proc Natl Acad Sci U S A. 2019 Dec 06. PMID: 31811024; PMCID: PMC6936714.
    Citations: 26     Fields:    
  8. Iyer SS, Gensollen T, Gandhi A, Oh SF, Neves JF, Collin F, Lavin R, Serra C, Glickman J, de Silva PSA, Sartor RB, Besra G, Hauser R, Maxwell A, Llebaria A, Blumberg RS. Dietary and Microbial Oxazoles Induce Intestinal Inflammation by Modulating Aryl Hydrocarbon Receptor Responses. Cell. 2018 05 17; 173(5):1123-1134.e11. PMID: 29775592.
    Citations: 40     Fields:    Translation:AnimalsCells
  9. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016 Apr; 22(4):421-6. PMID: 26950361; PMCID: PMC4949205.
    Citations: 191     Fields:    Translation:HumansAnimals
  10. Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C. MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of ROR?? regulatory T cells. Science. 2015 Aug 28; 349(6251):993-7. PMID: 26272906; PMCID: PMC4700932.
    Citations: 328     Fields:    Translation:HumansAnimalsCells
  11. An D, Oh SF, Olszak T, Neves JF, Avci FY, Erturk-Hasdemir D, Lu X, Zeissig S, Blumberg RS, Kasper DL. Sphingolipids from a symbiotic microbe regulate homeostasis of host intestinal natural killer T cells. Cell. 2014 Jan 16; 156(1-2):123-33. PMID: 24439373.
    Citations: 239     Fields:    Translation:AnimalsCells
  12. Rogerio AP, Haworth O, Croze R, Oh SF, Uddin M, Carlo T, Pfeffer MA, Priluck R, Serhan CN, Levy BD. Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. J Immunol. 2012 Aug 15; 189(4):1983-91. PMID: 22802419; PMCID: PMC3534750.
    Citations: 108     Fields:    Translation:AnimalsCells
  13. Chiang N, Fredman G, Bäckhed F, Oh SF, Vickery T, Schmidt BA, Serhan CN. Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature. 2012 Apr 25; 484(7395):524-8. PMID: 22538616.
    Citations: 304     Fields:    Translation:HumansAnimalsCells
  14. Oh SF, Dona M, Fredman G, Krishnamoorthy S, Irimia D, Serhan CN. Resolvin E2 formation and impact in inflammation resolution. J Immunol. 2012 May 01; 188(9):4527-34. PMID: 22450811; PMCID: PMC3331964.
    Citations: 75     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  15. Tobin DM, Roca FJ, Oh SF, McFarland R, Vickery TW, Ray JP, Ko DC, Zou Y, Bang ND, Chau TT, Vary JC, Hawn TR, Dunstan SJ, Farrar JJ, Thwaites GE, King MC, Serhan CN, Ramakrishnan L. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell. 2012 Feb 03; 148(3):434-46. PMID: 22304914.
    Citations: 256     Fields:    Translation:HumansAnimalsCells
  16. Yang R, Chiang N, Oh SF, Serhan CN. Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. Curr Protoc Immunol. 2011 Nov; Chapter 14:Unit 14.26. PMID: 22048801.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  17. Fredman G, Oh SF, Ayilavarapu S, Hasturk H, Serhan CN, Van Dyke TE. Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1. PLoS One. 2011; 6(9):e24422. PMID: 21935407.
    Citations: 66     Fields:    Translation:HumansCells
  18. Oh SF, Vickery TW, Serhan CN. Chiral lipidomics of E-series resolvins: aspirin and the biosynthesis of novel mediators. Biochim Biophys Acta. 2011 Nov; 1811(11):737-47. PMID: 21712098.
    Citations: 21     Fields:    Translation:HumansAnimals
  19. Oh SF, Pillai PS, Recchiuti A, Yang R, Serhan CN. Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. J Clin Invest. 2011 Feb; 121(2):569-81. PMID: 21206090; PMCID: PMC3026718.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  20. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med. 2009 Jan 16; 206(1):15-23. PMID: 19103881.
    Citations: 321     Fields:    Translation:HumansAnimalsCells
  21. Hong S, Porter TF, Lu Y, Oh SF, Pillai PS, Serhan CN. Resolvin E1 metabolome in local inactivation during inflammation-resolution. J Immunol. 2008 Mar 01; 180(5):3512-9. PMID: 18292578.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  22. Sun YP, Oh SF, Uddin J, Yang R, Gotlinger K, Campbell E, Colgan SP, Petasis NA, Serhan CN. Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30; 282(13):9323-9334. PMID: 17244615.
    Citations: 240     Fields:    Translation:HumansAnimalsCells
  23. Tjonahen E, Oh SF, Siegelman J, Elangovan S, Percarpio KB, Hong S, Arita M, Serhan CN. Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. Chem Biol. 2006 Nov; 13(11):1193-202. PMID: 17114001.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  24. Arita M, Oh SF, Chonan T, Hong S, Elangovan S, Sun YP, Uddin J, Petasis NA, Serhan CN. Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions. J Biol Chem. 2006 Aug 11; 281(32):22847-54. PMID: 16757471.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  25. Liu W, Cao D, Oh SF, Serhan CN, Kulmacz RJ. Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun; 20(8):1097-108. PMID: 16770009.
    Citations: 23     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.