Harvard Catalyst Profiles

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Julia Ruth Koehler, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI148235 (KOEHLER, JULIA R) May 15, 2020 - Apr 30, 2024
    NIH
    Inhibiting sequential biosynthetic steps of a fungal-specific organelle
    Role: Principal Investigator
  2. G08LM013191 (KOEHLER, JULIA R) Aug 1, 2019 - Apr 30, 2022
    NIH
    Bridging Neglect: improved access to high-quality heart health information and care for communities at risk of Chagas disease
    Role: Principal Investigator
  3. R33AI141189 (KOEHLER, JULIA R) Feb 1, 2019 - Jan 31, 2024
    NIH
    Compounds that block a novel Candida albicans target
    Role: Principal Investigator
  4. R21AI141189 (KOEHLER, JULIA R) Feb 1, 2019 - Jan 31, 2022
    NIH
    Compounds that block a novel Candida albicans target
    Role: Principal Investigator
  5. R21AI137716 (KOEHLER, JULIA R) Jan 12, 2018 - Dec 31, 2020
    NIH
    Role of Candida albicans phosphate transport in cell wall maintenance and echinocandin tolerance
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Köhler JR, Acosta-Zaldívar M, Qi W. Phosphate in Virulence of Candida albicans and Candida glabrata. J Fungi (Basel). 2020 Mar 26; 6(2). PMID: 32224872.
    Citations: 2     
  2. Liu NN, Acosta-Zaldívar M, Qi W, Diray-Arce J, Walker LA, Kottom TJ, Kelly R, Yuan M, Asara JM, Lasky-Su JA, Levy O, Limper AH, Gow NAR, Köhler JR. Phosphoric Metabolites Link Phosphate Import and Polysaccharide Biosynthesis for Candida albicans Cell Wall Maintenance. mBio. 2020 03 17; 11(2). PMID: 32184254.
    Citations: 3     Fields:    Translation:AnimalsCells
  3. Ganapathi L, Caldas A, Miranda J, Köhler JR, Visner G, Sawicki G. Medical Deferred Action - Living on Borrowed Time. N Engl J Med. 2019 Oct 24; 381(17):1601-1603. PMID: 31577869.
    Citations:    Fields:    Translation:Humans
  4. Romo JA, Zhang H, Cai H, Kadosh D, Koehler JR, Saville SP, Wang Y, Lopez-Ribot JL. Global Transcriptomic Analysis of the Candida albicans Response to Treatment with a Novel Inhibitor of Filamentation. mSphere. 2019 09 11; 4(5). PMID: 31511371.
    Citations: 6     Fields:    Translation:AnimalsCells
  5. Uppuluri P, Acosta Zaldívar M, Anderson MZ, Dunn MJ, Berman J, Lopez Ribot JL, Köhler JR. Candida albicans Dispersed Cells Are Developmentally Distinct from Biofilm and Planktonic Cells. mBio. 2018 08 21; 9(4). PMID: 30131358.
    Citations: 21     Fields:    Translation:Animals
  6. Liu NN, Uppuluri P, Broggi A, Besold A, Ryman K, Kambara H, Solis N, Lorenz V, Qi W, Acosta-Zaldívar M, Emami SN, Bao B, An D, Bonilla FA, Sola-Visner M, Filler SG, Luo HR, Engström Y, Ljungdahl PO, Culotta VC, Zanoni I, Lopez-Ribot JL, Köhler JR. Intersection of phosphate transport, oxidative stress and TOR signalling in Candida albicans virulence. PLoS Pathog. 2018 07; 14(7):e1007076. PMID: 30059535.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. García C, Tebbji F, Daigneault M, Liu NN, Köhler JR, Allen-Vercoe E, Sellam A. The Human Gut Microbial Metabolome Modulates Fungal Growth via the TOR Signaling Pathway. mSphere. 2017 Nov-Dec; 2(6). PMID: 29242837.
    Citations: 11     Fields:    
  8. Flanagan PR, Liu NN, Fitzpatrick DJ, Hokamp K, Köhler JR, Moran GP. The Candida albicans TOR-Activating GTPases Gtr1 and Rhb1 Coregulate Starvation Responses and Biofilm Formation. mSphere. 2017 Nov-Dec; 2(6). PMID: 29152581.
    Citations: 7     Fields:    
  9. Santus W, Barresi S, Mingozzi F, Broggi A, Orlandi I, Stamerra G, Vai M, Martorana AM, Polissi A, Köhler JR, Liu N, Zanoni I, Granucci F. Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems. Sci Immunol. 2017 Sep 22; 2(15). PMID: 28939652.
    Citations: 11     Fields:    
  10. Köhler JR, Hube B, Puccia R, Casadevall A, Perfect JR. Fungi that Infect Humans. Microbiol Spectr. 2017 06; 5(3). PMID: 28597822.
    Citations: 33     Fields:    Translation:HumansAnimals
  11. Liu NN, Flanagan PR, Zeng J, Jani NM, Cardenas ME, Moran GP, Köhler JR. Phosphate is the third nutrient monitored by TOR in Candida albicans and provides a target for fungal-specific indirect TOR inhibition. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):6346-6351. PMID: 28566496.
    Citations: 14     Fields:    Translation:AnimalsCells
  12. Shekhar-Guturja T, Tebung WA, Mount H, Liu N, Köhler JR, Whiteway M, Cowen LE. Beauvericin Potentiates Azole Activity via Inhibition of Multidrug Efflux, Blocks Candida albicans Morphogenesis, and Is Effluxed via Yor1 and Circuitry Controlled by Zcf29. Antimicrob Agents Chemother. 2016 12; 60(12):7468-7480. PMID: 27736764.
    Citations: 17     Fields:    Translation:AnimalsCells
  13. Liu NN, Köhler JR. Antagonism of Fluconazole and a Proton Pump Inhibitor against Candida albicans. Antimicrob Agents Chemother. 2016 Feb; 60(2):1145-7. PMID: 26596946.
    Citations: 7     Fields:    Translation:AnimalsCells
  14. Chowdhury T, Köhler JR. Ribosomal protein S6 phosphorylation is controlled by TOR and modulated by PKA in Candida albicans. Mol Microbiol. 2015 Oct; 98(2):384-402. PMID: 26173379.
    Citations: 10     Fields:    Translation:AnimalsCells
  15. Köhler JR, Sola-Visner M. The silent crisis: children hurt by current immigration enforcement policies. JAMA Pediatr. 2014 Feb; 168(2):103-4. PMID: 24366554.
    Citations:    Fields:    Translation:Humans
  16. Uppuluri P, Chaturvedi AK, Jani N, Pukkila-Worley R, Monteagudo C, Mylonakis E, Köhler JR, Lopez Ribot JL. Physiologic expression of the Candida albicans pescadillo homolog is required for virulence in a murine model of hematogenously disseminated candidiasis. Eukaryot Cell. 2012 Dec; 11(12):1552-6. PMID: 23104566.
    Citations: 3     Fields:    Translation:Animals
  17. Cowen LE, Singh SD, Köhler JR, Collins C, Zaas AK, Schell WA, Aziz H, Mylonakis E, Perfect JR, Whitesell L, Lindquist S. Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2818-23. PMID: 19196973.
    Citations: 153     Fields:    Translation:HumansAnimals
  18. Shen J, Cowen LE, Griffin AM, Chan L, Köhler JR. The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20918-23. PMID: 19075239.
    Citations: 30     Fields:    Translation:HumansAnimals
  19. Koh AY, Köhler JR, Coggshall KT, Van Rooijen N, Pier GB. Mucosal damage and neutropenia are required for Candida albicans dissemination. PLoS Pathog. 2008 Feb 08; 4(2):e35. PMID: 18282097.
    Citations: 134     Fields:    Translation:Animals
  20. Shen J, Guo W, Köhler JR. CaNAT1, a heterologous dominant selectable marker for transformation of Candida albicans and other pathogenic Candida species. Infect Immun. 2005 Feb; 73(2):1239-42. PMID: 15664973.
    Citations: 59     Fields:    Translation:Animals
  21. Köhler JR. Mos10 (Vps60) is required for normal filament maturation in Saccharomyces cerevisiae. Mol Microbiol. 2003 Sep; 49(5):1267-85. PMID: 12940986.
    Citations: 6     Fields:    Translation:AnimalsCells
  22. Lo HJ, Köhler JR, DiDomenico B, Loebenberg D, Cacciapuoti A, Fink GR. Nonfilamentous C. albicans mutants are avirulent. Cell. 1997 Sep 05; 90(5):939-49. PMID: 9298905.
    Citations: 716     Fields:    Translation:AnimalsCells
  23. Köhler JR, Fink GR. Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13223-8. PMID: 8917572.
    Citations: 103     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.