Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

profileRichard Lee Frock, Ph.D.

TitleResearch Fellow in Genetics (EXT)
InstitutionBoston Children's Hospital
AddressChildrens Hospital
Karp 09216
300 Longwood Ave
Boston MA 02115
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Willis NA, Frock RL, Menghi F, Duffey EE, Panday A, Camacho V, Hasty EP, Liu ET, Alt FW, Scully R. Mechanism of tandem duplication formation in BRCA1-mutant cells. Nature. 2017 Nov 30; 551(7682):590-595. PMID: 29168504.
    View in: PubMed
  2. Kumar V, Alt FW, Frock RL. PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line. Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38):10619-24. PMID: 27601633.
    View in: PubMed
  3. Zhao L, Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW. Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development. J Exp Med. 2016 Aug 22; 213(9):1921-36. PMID: 27526713; PMCID: PMC4995090 [Available on 02/22/17].
  4. Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL. Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nat Protoc. 2016 May; 11(5):853-71. PMID: 27031497; PMCID: PMC4895203 [Available on 11/01/16].
  5. Hu J, Zhang Y, Zhao L, Frock RL, Du Z, Meyers RM, Meng FL, Schatz DG, Alt FW. Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes. Cell. 2015 Nov 05; 163(4):947-59. PMID: 26593423; PMCID: PMC4660266 [Available on 11/05/16].
  6. Frock RL, Hu J, Meyers RM, Ho YJ, Kii E, Alt FW. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat Biotechnol. 2015 Feb; 33(2):179-86. PMID: 25503383; PMCID: PMC4320661.
  7. Frock RL, Chen SC, Da DF, Frett E, Lau C, Brown C, Pak DN, Wang Y, Muchir A, Worman HJ, Santana LF, Ladiges WC, Rabinovitch PS, Kennedy BK. Cardiomyocyte-specific expression of lamin a improves cardiac function in Lmna-/- mice. PLoS One. 2012; 7(8):e42918. PMID: 22905185; PMCID: PMC3419749.
  8. Chiarle R, Zhang Y, Frock RL, Lewis SM, Molinie B, Ho YJ, Myers DR, Choi VW, Compagno M, Malkin DJ, Neuberg D, Monti S, Giallourakis CC, Gostissa M, Alt FW. Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell. 2011 Sep 30; 147(1):107-19. PMID: 21962511; PMCID: PMC3186939.
  9. Hale JS, Frock RL, Mamman SA, Fink PJ, Kennedy BK. Cell-extrinsic defective lymphocyte development in Lmna(-/-) mice. PLoS One. 2010 Apr 12; 5(4):e10127. PMID: 20405040; PMCID: PMC2853576.
  10. Frock RL, Kudlow BA, Evans AM, Jameson SA, Hauschka SD, Kennedy BK. Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation. Genes Dev. 2006 Feb 15; 20(4):486-500. PMID: 16481476; PMCID: PMC1369050.
  11. Smith ED, Kudlow BA, Frock RL, Kennedy BK. A-type nuclear lamins, progerias and other degenerative disorders. Mech Ageing Dev. 2005 Apr; 126(4):447-60. PMID: 15722103.
    View in: PubMed
  12. Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E, Kennedy BK. A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9677-82. PMID: 15210943; PMCID: PMC470734.
  13. Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E, Kennedy BK. Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit. Mol Cell Biol. 2004 Jan; 24(2):595-607. PMID: 14701733; PMCID: PMC343811.
  14. Deng WM, Schneider M, Frock R, Castillejo-Lopez C, Gaman EA, Baumgartner S, Ruohola-Baker H. Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila. Development. 2003 Jan; 130(1):173-84. PMID: 12441301.
    View in: PubMed
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