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Wayne G Shreffler, M.D., Ph.D.


Our research program involves a combination of approaches, primarily with human samples and often in conjunction with clinical interventional or observational studies, to interrogate both the innate and adaptive immune responses to major dietary and aeroallergens.

Working together with leading clinical investigators around the world as part of the Consortium for Food Allergy Research and the Inner City Asthma Consortium and the newly established Food Allergy Research Center at MGH, we are adapting the use of polychromatic flow cytometry and peptide microarray-based humoral immune profiling and systems biology approaches to uniquely characterize the phenotype and function of allergen-specific T and B cell responses and the regulations of effector cells in pediatric food allergy and asthma.

Equally important is the effort to understand the mechanisms that influence early immune fate decisions to allergens and the intrinsic properties of those allergens that facilitate an allergic response and we are studying this in human and murine model systems.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13AI150089 (SHREFFLER, WAYNE G) Dec 12, 2019 - Nov 30, 2020
    2020 Food Allergy Gordon Research Conference and Gordon Research Seminar
    Role: Principal Investigator
  2. UM1AI130934 (SHREFFLER, WAYNE G) Mar 1, 2017 - Feb 28, 2022
    Immune progression and plasticity in relation to child age
    Role: Principal Investigator
  3. U19AI095261 (LUSTER, ANDREW D) Aug 5, 2011 - Jul 31, 2016
    T cell effector and regulatory mechanisms in asthma and food allergy
    Role: Co-Principal Investigator
  4. R01AI081845 (SHREFFLER, WAYNE G) Jun 11, 2010 - Nov 30, 2016
    Mechanisms of Clinical Reactivity or Tolerance to Mouse Allergen
    Role: Principal Investigator
  5. R03AI079544 (SHREFFLER, WAYNE G) Sep 15, 2008 - Feb 28, 2011
    Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Seay HL, Martin VM, Virkud YV, Marget M, Shreffler WG, Yuan Q. Prospective associations between acid suppressive therapy and food allergy in early childhood. Clin Exp Allergy. 2022 May; 52(5):711-714. PMID: 35285103.
    Citations:    Fields:    Translation:Humans
  2. Baker J, Beyer K, du Toit G, Shreffler W, Brown KR, Norval D, Vereda A, Adelman D, Jones SM, Burks W, Casale T. Reply. J Allergy Clin Immunol. 2022 Apr 28. PMID: 35491264.
    Citations:    Fields:    
  3. Martin VM, Marget M, Yuan Q, Shreffler WG. In response to Frequency of guideline-defined cow's milk allergy symptoms in infants: Secondary analysis of EAT trial data by Vincent et al. Clin Exp Allergy. 2022 Apr; 52(4):581-582. PMID: 34981585.
    Citations:    Fields:    
  4. Roy IR, Hazi A, Esteban CA, André M, Virkud Y, Shreffler WG, Pistiner M. Evaluation of a group visit model for access to infant and toddler oral food challenges. J Allergy Clin Immunol Pract. 2022 Feb 03. PMID: 35123102.
    Citations:    Fields:    
  5. Stidham S, Villareal V, Chellappa V, Yoder L, Alley O, Shreffler W, Spergel J, Fleischer D, Sampson H, Gilboa-Geffen A. Aptamer based point of care diagnostic for the detection of food allergens. Sci Rep. 2022 01 25; 12(1):1303. PMID: 35079047.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Monian B, Tu AA, Ruiter B, Morgan DM, Petrossian PM, Smith NP, Gierahn TM, Ginder JH, Shreffler WG, Love JC. Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells. J Clin Invest. 2022 01 18; 132(2). PMID: 34813505.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  7. Chinthrajah RS, Jones SM, Kim EH, Sicherer SH, Shreffler W, Lanser BJ, Atri N, Babineau DC, Adelman DC, Iqbal A, Limb SL, Rudman Spergel AK, Togias A, Wood RA. Updating the CoFAR Grading Scale for Systemic Allergic Reactions in Food Allergy. J Allergy Clin Immunol. 2022 Jan 11. PMID: 35026206.
    Citations:    Fields:    
  8. Bartsch YC, St Denis KJ, Kaplonek P, Kang J, Lam EC, Burns MD, Farkas EJ, Davis JP, Boribong BP, Edlow AG, Fasano A, Shreffler W, Zavadska D, Johnson M, Goldblatt D, Balazs AB, Yonker LM, Alter G. Comprehensive antibody profiling of mRNA vaccination in children. bioRxiv. 2022 Jan 04. PMID: 35018376.
  9. Brown KR, Baker J, Vereda A, Beyer K, Burks AW, du Toit G, O'B Hourihane J, Jones SM, Norval D, Dana A, Shreffler W, Vickery BP, Casale T, Skeel B, Adelman D. Safety of peanut (Arachis hypogaea) allergen powder-dnfp in children and teenagers with peanut allergy: Pooled summary of phase 3 and extension trials. J Allergy Clin Immunol. 2021 Dec 29. PMID: 34971646.
    Citations:    Fields:    
  10. Pongracic JA, Gagnon R, Sussman G, Siri D, Oriel RC, Brown-Whitehorn TF, Green TD, Campbell DE, Anvari S, Berger WE, Bird JA, Chan ES, Cheema A, Chinthrajah RS, Chong HJ, Dowling PJ, Fineman SM, Fleischer DM, Gonzalez-Reyes E, Kim EH, Lanser BJ, MacGinnitie A, Mehta H, Petroni D, Rupp N, Schneider LC, Scurlock AM, Sher LD, Shreffler WG, Sindher SB, Stillerman A, Wood R, Yang WH, Bois T, Sampson HA, Bégin P. Safety of Epicutaneous Immunotherapy in Peanut-Allergic Children: REALISE Randomized Clinical Trial Results. J Allergy Clin Immunol Pract. 2021 Nov 27. PMID: 34848381.
    Citations:    Fields:    
  11. Ruiter B, Shreffler WG. Reply. J Allergy Clin Immunol. 2022 01; 149(1):451-452. PMID: 34674854.
    Citations:    Fields:    
  12. De Kam PJ, Kramer MF, Shamji MH, Oluwayi K, Heath MD, Jensen-Jarolim E, Berger MH, Berger UE, Graessel A, Sellwood F, Zielen S, Vogelberg C, Zieglmayer P, Mösges R, Klimek L, DuBuske LM, Shreffler WG, Bernstein JA, Kündig TM, Skinner MA. Dogmas, challenges, and promises in phase III allergen immunotherapy studies. World Allergy Organ J. 2021 Sep; 14(9):100578. PMID: 34659627.
  13. Morgan DM, Ruiter B, Smith NP, Tu AA, Monian B, Stone BE, Virk-Hundal N, Yuan Q, Shreffler WG, Love JC. Clonally expanded, GPR15-expressing pathogenic effector TH2 cells are associated with eosinophilic esophagitis. Sci Immunol. 2021 08 13; 6(62). PMID: 34389613.
    Citations: 1     Fields:    Translation:HumansCells
  14. Smith NP, Ruiter B, Virkud YV, Tu AA, Monian B, Moon JJ, Love JC, Shreffler WG. Identification of antigen-specific TCR sequences based on biological and statistical enrichment in unselected individuals. JCI Insight. 2021 07 08; 6(13). PMID: 34032640.
    Citations: 2     Fields:    Translation:HumansCells
  15. Keet C, Shreffler W, Togias A, Pistiner M. Reply. J Allergy Clin Immunol. 2021 07; 148(1):275. PMID: 33966897.
    Citations:    Fields:    
  16. Keet C, Shreffler W, Wood R, Togias A, Pistiner M. Reply. J Allergy Clin Immunol. 2021 07; 148(1):273. PMID: 33926728.
    Citations:    Fields:    
  17. Su KW, Shreffler WG, Yuan Q. Gastrointestinal immunopathology of food protein-induced enterocolitis syndrome and other non-immunoglobulin E-mediated food allergic diseases. Ann Allergy Asthma Immunol. 2021 05; 126(5):516-523. PMID: 33667639.
    Citations: 1     Fields:    Translation:HumansCells
  18. Keet C, Plesa M, Szelag D, Shreffler W, Wood R, Dunlop J, Peng R, Dantzer J, Hamilton RG, Togias A, Pistiner M. Ara h 2-specific IgE is superior to whole peanut extract-based serology or skin prick test for diagnosis of peanut allergy in infancy. J Allergy Clin Immunol. 2021 03; 147(3):977-983.e2. PMID: 33483152.
    Citations: 1     Fields:    Translation:HumansAnimals
  19. Keet C, Pistiner M, Plesa M, Szelag D, Shreffler W, Wood R, Dunlop J, Peng R, Dantzer J, Togias A. Age and eczema severity, but not family history, are major risk factors for peanut allergy in infancy. J Allergy Clin Immunol. 2021 03; 147(3):984-991.e5. PMID: 33483153.
    Citations: 3     Fields:    Translation:HumansAnimals
  20. Ruiter B, Smith NP, Fleming E, Patil SU, Hurlburt BK, Maleki SJ, Shreffler WG. Peanut protein acts as a TH2 adjuvant by inducing RALDH2 in human antigen-presenting cells. J Allergy Clin Immunol. 2021 07; 148(1):182-194.e4. PMID: 33378690.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. Vickery BP, Vereda A, Nilsson C, du Toit G, Shreffler WG, Burks AW, Jones SM, Fernández-Rivas M, Blümchen K, O'B Hourihane J, Beyer K, Smith A, Ryan R, Adelman DC. Continuous and Daily Oral Immunotherapy for Peanut Allergy: Results from a 2-Year Open-Label Follow-On Study. J Allergy Clin Immunol Pract. 2021 05; 9(5):1879-1889.e14. PMID: 33359589.
    Citations: 5     Fields:    Translation:HumansAnimals
  22. Martin VM, Virkud YV, Phadke NA, Su KW, Seay H, Atkins MR, Keet C, Shreffler WG, Yuan Q. Increased IgE-Mediated Food Allergy With Food Protein-Induced Allergic Proctocolitis. Pediatrics. 2020 09; 146(3). PMID: 32855350.
    Citations: 1     Fields:    Translation:Humans
  23. Fleischer DM, Shreffler WG, Campbell DE, Green TD, Anvari S, Assa'ad A, Bégin P, Beyer K, Bird JA, Brown-Whitehorn T, Byrne A, Chan ES, Cheema A, Chinthrajah S, Chong HJ, Davis CM, Ford LS, Gagnon R, Greenhawt M, Hourihane JO, Jones SM, Kim EH, Lange L, Lanser BJ, Leonard S, Mahler V, Maronna A, Nowak-Wegrzyn A, Oriel RC, O'Sullivan M, Petroni D, Pongracic JA, Prescott SL, Schneider LC, Smith P, Staab D, Sussman G, Wood R, Yang WH, Lambert R, Peillon A, Bois T, Sampson HA. Long-term, open-label extension study of the efficacy and safety of epicutaneous immunotherapy for peanut allergy in children: PEOPLE 3-year results. J Allergy Clin Immunol. 2020 10; 146(4):863-874. PMID: 32659313.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  24. Esteban CA, Shreffler WG, Virkud YV, Pistiner M. Oral food challenge outcomes in children under 3 years of age. J Allergy Clin Immunol Pract. 2020 Nov - Dec; 8(10):3653-3656.e3. PMID: 32603899.
    Citations:    Fields:    Translation:Humans
  25. Pepper AN, Assa'ad A, Blaiss M, Brown E, Chinthrajah S, Ciaccio C, Fasano MB, Gupta R, Hong N, Lang D, Mahr T, Malawer E, Roach A, Shreffler W, Sicherer S, Vickers K, Vickery BP, Wasserman R, Yates K, Casale TB. Consensus report from the Food Allergy Research & Education (FARE) 2019 Oral Immunotherapy for Food Allergy Summit. J Allergy Clin Immunol. 2020 08; 146(2):244-249. PMID: 32505612.
    Citations: 2     Fields:    Translation:HumansAnimals
  26. Shade KC, Conroy ME, Washburn N, Kitaoka M, Huynh DJ, Laprise E, Patil SU, Shreffler WG, Anthony RM. Sialylation of immunoglobulin E is a determinant of allergic pathogenicity. Nature. 2020 06; 582(7811):265-270. PMID: 32499653.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  27. Su KW, Patil SU, Stockbridge JL, Martin VM, Virkud YV, Huang JL, Shreffler WG, Yuan Q. Food aversion and poor weight gain in food protein-induced enterocolitis syndrome: A retrospective study. J Allergy Clin Immunol. 2020 05; 145(5):1430-1437.e11. PMID: 31940468.
    Citations: 4     Fields:    Translation:HumansAnimals
  28. Martin VM, Virkud YV, Seay H, Hickey A, Ndahayo R, Rosow R, Southwick C, Elkort M, Gupta B, Kramer E, Pronchick T, Reuter S, Keet C, Su KW, Shreffler WG, Yuan Q. Prospective Assessment of Pediatrician-Diagnosed Food Protein-Induced Allergic Proctocolitis by Gross or Occult Blood. J Allergy Clin Immunol Pract. 2020 05; 8(5):1692-1699.e1. PMID: 31917366.
    Citations: 9     Fields:    Translation:HumansAnimals
  29. Shreffler WG. Promise of personalized medicine. Ann Allergy Asthma Immunol. 2019 12; 123(6):534. PMID: 31761013.
    Citations:    Fields:    Translation:Humans
  30. Tu AA, Gierahn TM, Monian B, Morgan DM, Mehta NK, Ruiter B, Shreffler WG, Shalek AK, Love JC. TCR sequencing paired with massively parallel 3' RNA-seq reveals clonotypic T cell signatures. Nat Immunol. 2019 12; 20(12):1692-1699. PMID: 31745340.
    Citations: 25     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  31. Ruiter B, Smith NP, Monian B, Tu AA, Fleming E, Virkud YV, Patil SU, Whittaker CA, Love JC, Shreffler WG. Expansion of the CD4+ effector T-cell repertoire characterizes peanut-allergic patients with heightened clinical sensitivity. J Allergy Clin Immunol. 2020 01; 145(1):270-282. PMID: 31654649.
    Citations: 10     Fields:    Translation:HumansCellsCTClinical Trials
  32. Westerhout J, Baumert JL, Blom WM, Allen KJ, Ballmer-Weber B, Crevel RWR, Dubois AEJ, Fernández-Rivas M, Greenhawt MJ, Hourihane JO, Koplin JJ, Kruizinga AG, Le TM, Sampson HA, Shreffler WG, Turner PJ, Taylor SL, Houben GF, Remington BC. Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens. J Allergy Clin Immunol. 2019 11; 144(5):1290-1309. PMID: 31445097.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  33. Patil SU, Steinbrecher J, Calatroni A, Smith N, Ma A, Ruiter B, Virkud Y, Schneider M, Shreffler WG. Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapy. J Allergy Clin Immunol. 2019 11; 144(5):1310-1319.e4. PMID: 31377342.
    Citations: 13     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  34. Liao S, Patil SU, Shreffler WG, Dreskin SC, Chen X. Human monoclonal antibodies to Ara h 2 inhibit allergen-induced, IgE-mediated cell activation. Clin Exp Allergy. 2019 08; 49(8):1154-1157. PMID: 31134696.
    Citations: 1     Fields:    Translation:HumansCells
  35. Virkud YV, Chen YC, Stieb ES, Alejos AR, Renton N, Shreffler WG, Hesterberg PE. Analysis of Oral Food Challenge Outcomes in IgE-Mediated Food Allergies to Almond in a Large Cohort. J Allergy Clin Immunol Pract. 2019 Sep - Oct; 7(7):2359-2368.e3. PMID: 30974209.
    Citations: 3     Fields:    Translation:HumansAnimals
  36. Deak PE, Kim B, Abdul Qayum A, Shin J, Vitalpur G, Kloepfer KM, Turner MJ, Smith N, Shreffler WG, Kiziltepe T, Kaplan MH, Bilgicer B. Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):8966-8974. PMID: 30962381.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  37. Jiménez-Saiz R, Ellenbogen Y, Bruton K, Spill P, Sommer DD, Lima H, Waserman S, Patil SU, Shreffler WG, Jordana M. Human BCR analysis of single-sorted, putative IgE+ memory B cells in food allergy. J Allergy Clin Immunol. 2019 07; 144(1):336-339.e6. PMID: 30959060.
    Citations: 11     Fields:    Translation:HumansCells
  38. Fleischer DM, Greenhawt M, Sussman G, Bégin P, Nowak-Wegrzyn A, Petroni D, Beyer K, Brown-Whitehorn T, Hebert J, Hourihane JO, Campbell DE, Leonard S, Chinthrajah RS, Pongracic JA, Jones SM, Lange L, Chong H, Green TD, Wood R, Cheema A, Prescott SL, Smith P, Yang W, Chan ES, Byrne A, Assa'ad A, Bird JA, Kim EH, Schneider L, Davis CM, Lanser BJ, Lambert R, Shreffler W. Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial. JAMA. 2019 03 12; 321(10):946-955. PMID: 30794314.
    Citations: 46     Fields:    Translation:HumansAnimalsCTClinical Trials
  39. Vickery BP, Ebisawa M, Shreffler WG, Wood RA. Current and Future Treatment of Peanut Allergy. J Allergy Clin Immunol Pract. 2019 02; 7(2):357-365. PMID: 30717866.
    Citations: 10     Fields:    Translation:Humans
  40. Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez MD, Tilles S, Assa’ad AH, Nilsson C, Rupp N, Welch MJ, Sussman G, Chinthrajah S, Blumchen K, Sher E, Spergel JM, Leickly FE, Zielen S, Wang J, Sanders GM, Wood RA, Cheema A, Bindslev-Jensen C, Leonard S, Kachru R, Johnston DT, Hampel FC, Kim EH, Anagnostou A, Pongracic JA, Ben-Shoshan M, Sharma HP, Stillerman A, Windom HH, Yang WH, Muraro A, Zubeldia JM, Sharma V, Dorsey MJ, Chong HJ, Ohayon J, Bird JA, Carr TF, Siri D, Fernández-Rivas M, Jeong DK, Fleischer DM, Lieberman JA, Dubois AEJ, Tsoumani M, Ciaccio CE, Portnoy JM, Mansfield LE, Fritz SB, Lanser BJ, Matz J, Oude Elberink HNG, Varshney P, Dilly SG, Adelman DC, Burks AW. AR101 Oral Immunotherapy for Peanut Allergy. N Engl J Med. 2018 Nov 22; 379(21):1991-2001. PMID: 30449234.
    Citations: 98     Fields:    Translation:HumansAnimalsCTClinical Trials
  41. Virkud YV, Wang J, Shreffler WG. Enhancing the Safety and Efficacy of Food Allergy Immunotherapy: a Review of Adjunctive Therapies. Clin Rev Allergy Immunol. 2018 Oct; 55(2):172-189. PMID: 29968170.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  42. Grant T, Dantzer J, Keet C, Peng R, Paigen BJ, Krevans M, Hagberg K, Curtin-Brosnan J, Shreffler W, Matsui EC. Physician-diagnosed eczema is an independent risk factor for incident mouse skin test sensitization in adults. Allergy Asthma Proc. 2018 Jul 01; 39(4):311-315. PMID: 30111442.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  43. Patil SU, Shreffler WG. Novel vaccines: Technology and development. J Allergy Clin Immunol. 2019 03; 143(3):844-851. PMID: 29970235.
    Citations: 3     Fields:    Translation:HumansAnimals
  44. Vimalathas P, Farris A, Letner D, Deshpande V, Yajnik V, Shreffler W, Garber J. Integrin aM activation and upregulation on esophageal eosinophils and periostin-mediated eosinophil survival in eosinophilic esophagitis. Immunol Cell Biol. 2018 04; 96(4):426-438. PMID: 29424023.
    Citations: 3     Fields:    Translation:HumansCells
  45. Shreffler WG, Baumert JL, Remington BC, Koppelman SJ, Dinakar C, Fleischer DM, Kim E, Tilles SA, Spergel JM. The importance of reducing risk in peanut allergy: Current and future therapies. Ann Allergy Asthma Immunol. 2018 02; 120(2):124-127. PMID: 29289463.
    Citations: 2     Fields:    Translation:Humans
  46. Sampson HA, Shreffler WG, Yang WH, Sussman GL, Brown-Whitehorn TF, Nadeau KC, Cheema AS, Leonard SA, Pongracic JA, Sauvage-Delebarre C, Assa'ad AH, de Blay F, Bird JA, Tilles SA, Boralevi F, Bourrier T, Hébert J, Green TD, Gerth van Wijk R, Knulst AC, Kanny G, Schneider LC, Kowalski ML, Dupont C. Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity: A Randomized Clinical Trial. JAMA. 2017 11 14; 318(18):1798-1809. PMID: 29136445.
    Citations: 54     Fields:    Translation:HumansAnimalsCTClinical Trials
  47. Waserman S, Shreffler W, Jordana M. Probiotics and oral immunotherapy for peanut allergy. Lancet Child Adolesc Health. 2017 Nov; 1(3):e1. PMID: 30169173.
    Citations:    Fields:    
  48. Newton AN, Davis M, Koehler K, Shreffler W, Ahluwalia S, Metwali N, Thorne PS, Paigen BJ, Matsui EC. Atopy as a Modifier of the Relationships Between Endotoxin Exposure and Symptoms Among Laboratory Animal Workers. Ann Work Expo Health. 2017 Oct 01; 61(8):1024-1028. PMID: 29028247.
    Citations: 3     Fields:    Translation:HumansAnimalsPHPublic Health
  49. Santos AF, Shreffler WG. Road map for the clinical application of the basophil activation test in food allergy. Clin Exp Allergy. 2017 Sep; 47(9):1115-1124. PMID: 28618090.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  50. Patil SU, Calatroni A, Schneider M, Steinbrecher J, Smith N, Washburn C, Ma A, Shreffler WG. Data-driven programmatic approach to analysis of basophil activation tests. Cytometry B Clin Cytom. 2018 07; 94(4):667-673. PMID: 28618453.
    Citations: 4     Fields:    Translation:Humans
  51. Hourihane JO, Allen KJ, Shreffler WG, Dunngalvin G, Nordlee JA, Zurzolo GA, Dunngalvin A, Gurrin LC, Baumert JL, Taylor SL. Peanut Allergen Threshold Study (PATS): Novel single-dose oral food challenge study to validate eliciting doses in children with peanut allergy. J Allergy Clin Immunol. 2017 May; 139(5):1583-1590. PMID: 28238744.
    Citations: 12     Fields:    Translation:HumansAnimals
  52. Gern JE, Calatroni A, Jaffee KF, Lynn H, Dresen A, Cruikshank WW, Lederman HM, Sampson HA, Shreffler W, Bacharier LB, Gergen PJ, Gold DR, Kattan M, O'Connor GT, Sandel MT, Wood RA, Bloomberg GR. Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy. J Allergy Clin Immunol. 2017 Sep; 140(3):836-844.e7. PMID: 28089873.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  53. Martin VJ, Shreffler WG, Yuan Q. Presumed Allergic Proctocolitis Resolves with Probiotic Monotherapy: A Report of 4 Cases. Am J Case Rep. 2016 Aug 29; 17:621-4. PMID: 27568925.
    Citations: 4     Fields:    Translation:HumansCells
  54. Kakumanu S, Jaffee K, Visness CM, Dresen A, Burger M, Witter FR, O'Connor GT, Cruikshank WW, Shreffler WG, Bacharier LB, Gern JE. The influence of atopy and asthma on immune responses in inner-city adults. Immun Inflamm Dis. 2016 Mar; 4(1):80-90. PMID: 27042305.
    Citations: 1     Fields:    
  55. Gruchalla RS, Sampson HA, Liu AH, Shreffler W, Wallace PK, Togias A, David G, Calatroni A, LeBeau P. Effects of omalizumab on T lymphocyte function in inner-city children with asthma. Pediatr Allergy Immunol. 2016 05; 27(3):328-31. PMID: 26573086.
    Citations: 6     Fields:    Translation:HumansCells
  56. Berin MC, Shreffler WG. Mechanisms Underlying Induction of Tolerance to Foods. Immunol Allergy Clin North Am. 2016 Feb; 36(1):87-102. PMID: 26617229.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  57. Hoffmann HJ, Santos AF, Mayorga C, Nopp A, Eberlein B, Ferrer M, Rouzaire P, Ebo DG, Sabato V, Sanz ML, Pecaric-Petkovic T, Patil SU, Hausmann OV, Shreffler WG, Korosec P, Knol EF. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy. 2015 Nov; 70(11):1393-405. PMID: 26198455.
    Citations: 80     Fields:    Translation:HumansCells
  58. Leung J, Mehrzad R, Hundal NV, Alejos A, Hesterberg PE, Katz AJ, Yuan Q, Shreffler WG. Longitudinal Perspective on Managing Refractory Eosinophilic Esophagitis. J Allergy Clin Immunol Pract. 2015 Nov-Dec; 3(6):951-6. PMID: 26342740.
    Citations: 8     Fields:    Translation:Humans
  59. Ruiter B, Patil SU, Shreffler WG. Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells. Clin Exp Allergy. 2015 Jul; 45(7):1214-25. PMID: 25959810.
    Citations: 29     Fields:    Translation:HumansCells
  60. Patil SU, Ogunniyi AO, Calatroni A, Tadigotla VR, Ruiter B, Ma A, Moon J, Love JC, Shreffler WG. Peanut oral immunotherapy transiently expands circulating Ara h 2-specific B cells with a homologous repertoire in unrelated subjects. J Allergy Clin Immunol. 2015 Jul; 136(1):125-134.e12. PMID: 25985925.
    Citations: 34     Fields:    Translation:HumansCells
  61. Patil SU, Shreffler WG. BATting above average: basophil activation testing for peanut allergy. J Allergy Clin Immunol. 2014 Sep; 134(3):653-4. PMID: 25171867.
    Citations: 2     Fields:    Translation:Humans
  62. Keet C, Radano MC, Shreffler W. Re: Reply to Lifschitz. J Allergy Clin Immunol Pract. 2014 Sep-Oct; 2(5):643-4. PMID: 25213070.
    Citations:    Fields:    Translation:Humans
  63. Radano MC, Yuan Q, Katz A, Fleming JT, Kubala S, Shreffler W, Keet CA. Cesarean section and antibiotic use found to be associated with eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2014 Jul-Aug; 2(4):475-477.e1. PMID: 25017541.
    Citations: 28     Fields:    Translation:HumansPHPublic Health
  64. Tabatabaei N, Kang D, Wu T, Kim M, Carruth RW, Leung J, Sauk JS, Shreffler W, Yuan Q, Katz A, Nishioka NS, Tearney GJ. Tethered confocal endomicroscopy capsule for diagnosis and monitoring of eosinophilic esophagitis. Biomed Opt Express. 2013 Dec 13; 5(1):197-207. PMID: 24466487.
    Citations: 18     
  65. Kubala SA, Patil SU, Shreffler WG, Hurley BP. Pathogen induced chemo-attractant hepoxilin A3 drives neutrophils, but not eosinophils across epithelial barriers. Prostaglandins Other Lipid Mediat. 2014 Jan; 108:1-8. PMID: 24315875.
    Citations: 7     Fields:    Translation:HumansCells
  66. Keet CA, Shreffler WG, Peng RD, Matsui W, Matsui EC. Associations between serum folate and vitamin D levels and incident mouse sensitization in adults. J Allergy Clin Immunol. 2014 Feb; 133(2):399-404. PMID: 24290285.
    Citations: 4     Fields:    Translation:HumansAnimals
  67. Leung J, Hundal NV, Katz AJ, Shreffler WG, Yuan Q, Butterworth CA, Hesterberg PE. Tolerance of baked milk in patients with cow's milk-mediated eosinophilic esophagitis. J Allergy Clin Immunol. 2013 Nov; 132(5):1215-1216.e1. PMID: 24084076.
    Citations: 19     Fields:    Translation:HumansAnimals
  68. Zurzolo GA, Allen KJ, Taylor SL, Shreffler WG, Baumert JL, Tang ML, Gurrin LC, Mathai ML, Nordlee JA, Dunngalvin A, Hourihane JO. Peanut Allergen Threshold Study (PATS): validation of eliciting doses using a novel single-dose challenge protocol. Allergy Asthma Clin Immunol. 2013 Sep 12; 9(1):35. PMID: 24028324.
    Citations: 5     
  69. Islam SA, Ling MF, Leung J, Shreffler WG, Luster AD. Identification of human CCR8 as a CCL18 receptor. J Exp Med. 2013 Sep 23; 210(10):1889-98. PMID: 23999500.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  70. Katz A, Virk Hundal N, Yuan Q, Shreffler W. Cow's milk allergy: a new approach needed? J Pediatr. 2013 Sep; 163(3):620-2. PMID: 23809049.
    Citations: 2     Fields:    Translation:Humans
  71. Ruiter B, Shreffler WG. Innate immunostimulatory properties of allergens and their relevance to food allergy. Semin Immunopathol. 2012 Sep; 34(5):617-32. PMID: 22886110.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  72. Thyagarajan A, Jones SM, Calatroni A, Pons L, Kulis M, Woo CS, Kamalakannan M, Vickery BP, Scurlock AM, Wesley Burks A, Shreffler WG. Evidence of pathway-specific basophil anergy induced by peanut oral immunotherapy in peanut-allergic children. Clin Exp Allergy. 2012 Aug; 42(8):1197-205. PMID: 22805467.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  73. Ford LS, Bloom KA, Nowak-Wegrzyn AH, Shreffler WG, Masilamani M, Sampson HA. Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance. J Allergy Clin Immunol. 2013 Jan; 131(1):180-6.e1-3. PMID: 22819512.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  74. Burks AW, Jones SM, Wood RA, Fleischer DM, Sicherer SH, Lindblad RW, Stablein D, Henning AK, Vickery BP, Liu AH, Scurlock AM, Shreffler WG, Plaut M, Sampson HA. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med. 2012 Jul 19; 367(3):233-43. PMID: 22808958.
    Citations: 205     Fields:    Translation:Humans
  75. Ruiter B, Shreffler WG. The role of dendritic cells in food allergy. J Allergy Clin Immunol. 2012 Apr; 129(4):921-8. PMID: 22464669.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  76. Masilamani M, Commins S, Shreffler W. Determinants of food allergy. Immunol Allergy Clin North Am. 2012 Feb; 32(1):11-33. PMID: 22244230.
    Citations: 14     Fields:    Translation:HumansAnimalsPHPublic Health
  77. Patil SU, Shreffler WG. Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation. Clin Exp Immunol. 2012 Jan; 167(1):59-66. PMID: 22132885.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  78. Rosenfeld L, Shreffler W, Bardina L, Niggemann B, Wahn U, Sampson HA, Beyer K. Walnut allergy in peanut-allergic patients: significance of sequential epitopes of walnut homologous to linear epitopes of Ara h 1, 2 and 3 in relation to clinical reactivity. Int Arch Allergy Immunol. 2012; 157(3):238-45. PMID: 22042002.
    Citations: 5     Fields:    Translation:HumansAnimals
  79. Shreffler WG, Radano M. Food allergy and complementary feeding. Nestle Nutr Workshop Ser Pediatr Program. 2011; 68:141-9; discussion 150-2. PMID: 22044897.
    Citations: 2     Fields:    Translation:HumansAnimals
  80. Peng RD, Paigen B, Eggleston PA, Hagberg KA, Krevans M, Curtin-Brosnan J, Benson C, Shreffler WG, Matsui EC. Both the variability and level of mouse allergen exposure influence the phenotype of the immune response in workers at a mouse facility. J Allergy Clin Immunol. 2011 Aug; 128(2):390-396.e7. PMID: 21696812.
    Citations: 14     Fields:    Translation:HumansAnimalsPHPublic Health
  81. Shreffler WG. Microarrayed recombinant allergens for diagnostic testing. J Allergy Clin Immunol. 2011 Apr; 127(4):843-9; quiz 850-1. PMID: 21458654.
    Citations: 23     Fields:    Translation:HumansAnimals
  82. Kim EH, Bird JA, Kulis M, Laubach S, Pons L, Shreffler W, Steele P, Kamilaris J, Vickery B, Burks AW. Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization. J Allergy Clin Immunol. 2011 Mar; 127(3):640-6.e1. PMID: 21281959.
    Citations: 124     Fields:    Translation:HumansCTClinical Trials
  83. Ditto AM, Neilsen CV, Neerukonda S, Shreffler WG, Bryce PJ. Clinical reactivity to raw peanut correlates with IgE binding to conformational epitopes of Ara h 1: a case report. Allergy. 2010 Nov; 65(11):1485-6. PMID: 20412153.
    Citations: 3     Fields:    Translation:HumansCells
  84. Vereda A, Andreae DA, Lin J, Shreffler WG, Ibañez MD, Cuesta-Herranz J, Bardina L, Sampson HA. Identification of IgE sequential epitopes of lentil (Len c 1) by means of peptide microarray immunoassay. J Allergy Clin Immunol. 2010 Sep; 126(3):596-601.e1. PMID: 20816193.
    Citations: 7     Fields:    Translation:HumansAnimals
  85. Blumchen K, Ulbricht H, Staden U, Dobberstein K, Beschorner J, de Oliveira LC, Shreffler WG, Sampson HA, Niggemann B, Wahn U, Beyer K. Oral peanut immunotherapy in children with peanut anaphylaxis. J Allergy Clin Immunol. 2010 Jul; 126(1):83-91.e1. PMID: 20542324.
    Citations: 116     Fields:    Translation:Humans
  86. Sicherer SH, Wood RA, Stablein D, Burks AW, Liu AH, Jones SM, Fleischer DM, Leung DY, Grishin A, Mayer L, Shreffler W, Lindblad R, Sampson HA. Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy. J Allergy Clin Immunol. 2010 May; 125(5):1077-1083.e8. PMID: 20451041.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  87. Wang J, Lin J, Bardina L, Goldis M, Nowak-Wegrzyn A, Shreffler WG, Sampson HA. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. J Allergy Clin Immunol. 2010 Mar; 125(3):695-702, 702.e1-702.e6. PMID: 20226304.
    Citations: 60     Fields:    Translation:HumansCells
  88. Järvinen KM, Amalanayagam S, Shreffler WG, Noone S, Sicherer SH, Sampson HA, Nowak-Wegrzyn A. Epinephrine treatment is infrequent and biphasic reactions are rare in food-induced reactions during oral food challenges in children. J Allergy Clin Immunol. 2009 Dec; 124(6):1267-72. PMID: 20004784.
    Citations: 21     Fields:    Translation:Humans
  89. Lin J, Bardina L, Shreffler WG, Andreae DA, Ge Y, Wang J, Bruni FM, Fu Z, Han Y, Sampson HA. Development of a novel peptide microarray for large-scale epitope mapping of food allergens. J Allergy Clin Immunol. 2009 Aug; 124(2):315-22, 322.e1-3. PMID: 19577281.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  90. Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, Shreffler WG, Steele P, Henry KA, Adair M, Francis JM, Durham S, Vickery BP, Zhong X, Burks AW. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol. 2009 Aug; 124(2):292-300, 300.e1-97. PMID: 19577283.
    Citations: 224     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  91. Gern JE, Visness CM, Gergen PJ, Wood RA, Bloomberg GR, O'Connor GT, Kattan M, Sampson HA, Witter FR, Sandel MT, Shreffler WG, Wright RJ, Arbes SJ, Busse WW. The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population. BMC Pulm Med. 2009 May 08; 9:17. PMID: 19426496.
    Citations: 54     Fields:    Translation:Humans
  92. Wanich N, Nowak-Wegrzyn A, Sampson HA, Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol. 2009 Apr; 123(4):789-94.e20. PMID: 19348919.
    Citations: 43     Fields:    Translation:HumansCells
  93. Shreffler WG. The perfectly potent peanut. J Allergy Clin Immunol. 2009 Feb; 123(2):352-3. PMID: 19203659.
    Citations:    Fields:    Translation:HumansAnimals
  94. Lin J, Bardina L, Shreffler WG. Microarrayed allergen molecules for diagnostics of allergy. Methods Mol Biol. 2009; 524:259-72. PMID: 19377951.
    Citations: 6     Fields:    Translation:Humans
  95. Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol. 2009 Jan; 123(1):43-52.e7. PMID: 19130927.
    Citations: 75     Fields:    Translation:HumansCells
  96. Moloney M, Shreffler WG. Basic science for the practicing physician: flow cytometry and cell sorting. Ann Allergy Asthma Immunol. 2008 Nov; 101(5):544-9. PMID: 19055210.
    Citations: 4     Fields:    Translation:Humans
  97. Lemon-Mulé H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol. 2008 Nov; 122(5):977-983.e1. PMID: 18851876.
    Citations: 102     Fields:    Translation:Humans
  98. Cerecedo I, Zamora J, Shreffler WG, Lin J, Bardina L, Dieguez MC, Wang J, Muriel A, de la Hoz B, Sampson HA. Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay. J Allergy Clin Immunol. 2008 Sep; 122(3):589-94. PMID: 18774394.
    Citations: 39     Fields:    Translation:HumansCells
  99. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, Shreffler WG, Noone S, Wanich N, Sampson HA. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol. 2008 Aug; 122(2):342-7, 347.e1-2. PMID: 18620743.
    Citations: 119     Fields:    Translation:HumansAnimals
  100. Berin MC, Shreffler WG. T(H)2 adjuvants: implications for food allergy. J Allergy Clin Immunol. 2008 Jun; 121(6):1311-20; quiz 1321-2. PMID: 18539190.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  101. Hyman SJ, Shreffler WG, Rapaport R. Type 1 diabetes, autoimmune thyroid disease, and chronic urticaria. Pediatr Diabetes. 2008 Oct; 9(5):508-11. PMID: 18466206.
    Citations: 3     Fields:    Translation:Humans
  102. Flinterman AE, Knol EF, Lencer DA, Bardina L, den Hartog Jager CF, Lin J, Pasmans SG, Bruijnzeel-Koomen CA, Sampson HA, van Hoffen E, Shreffler WG. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol. 2008 Mar; 121(3):737-743.e10. PMID: 18234310.
    Citations: 57     Fields:    Translation:HumansAnimals
  103. Shreffler WG, Visness CM, Burger M, Cruikshank WW, Lederman HM, de la Morena M, Grindle K, Calatroni A, Sampson HA, Gern JE. Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study. BMC Immunol. 2006 Dec 12; 7:29. PMID: 17156490.
    Citations: 17     Fields:    Translation:HumansCells
  104. Shreffler WG, Castro RR, Kucuk ZY, Charlop-Powers Z, Grishina G, Yoo S, Burks AW, Sampson HA. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J Immunol. 2006 Sep 15; 177(6):3677-85. PMID: 16951327.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  105. Li H, Nowak-Wegrzyn A, Charlop-Powers Z, Shreffler W, Chehade M, Thomas S, Roda G, Dahan S, Sperber K, Berin MC. Transcytosis of IgE-antigen complexes by CD23a in human intestinal epithelial cells and its role in food allergy. Gastroenterology. 2006 Jul; 131(1):47-58. PMID: 16831589.
    Citations: 30     Fields:    Translation:HumansCells
  106. Shreffler WG, Charlop-Powers Z, Sicherer SH. Lack of association of HLA class II alleles with peanut allergy. Ann Allergy Asthma Immunol. 2006 Jun; 96(6):865-9. PMID: 16802776.
    Citations: 16     Fields:    Translation:Humans
  107. Shreffler WG. Evaluation of basophil activation in food allergy: present and future applications. Curr Opin Allergy Clin Immunol. 2006 Jun; 6(3):226-33. PMID: 16670519.
    Citations: 17     Fields:    Translation:HumansCells
  108. Knight AK, Shreffler WG, Sampson HA, Sicherer SH, Noone S, Mofidi S, Nowak-Wegrzyn A. Skin prick test to egg white provides additional diagnostic utility to serum egg white-specific IgE antibody concentration in children. J Allergy Clin Immunol. 2006 Apr; 117(4):842-7. PMID: 16630943.
    Citations: 14     Fields:    Translation:Humans
  109. Shreffler WG, Lencer DA, Bardina L, Sampson HA. IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol. 2005 Oct; 116(4):893-9. PMID: 16210066.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  110. Shreffler WG, Beyer K, Chu TH, Burks AW, Sampson HA. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol. 2004 Apr; 113(4):776-82. PMID: 15100687.
    Citations: 73     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.