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Wayne G Shreffler, M.D., Ph.D.

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Overview
Our research program involves a combination of approaches, primarily with human samples and often in conjunction with clinical interventional or observational studies, to interrogate both the innate and adaptive immune responses to major dietary and aeroallergens.

Working together with leading clinical investigators around the world as part of the Consortium for Food Allergy Research and the Inner City Asthma Consortium and the newly established Food Allergy Research Center at MGH, we are adapting the use of polychromatic flow cytometry and peptide microarray-based humoral immune profiling and systems biology approaches to uniquely characterize the phenotype and function of allergen-specific T and B cell responses and the regulations of effector cells in pediatric food allergy and asthma.

Equally important is the effort to understand the mechanisms that influence early immune fate decisions to allergens and the intrinsic properties of those allergens that facilitate an allergic response and we are studying this in human and murine model systems.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13AI150089 (SHREFFLER, WAYNE G) Dec 12, 2019 - Nov 30, 2020
    NIH/NIAID
    2020 Food Allergy Gordon Research Conference and Gordon Research Seminar
    Role: Principal Investigator
  2. UM1AI130934 (SHREFFLER, WAYNE G) Mar 1, 2017 - Feb 28, 2022
    NIH/NIAID
    Immune progression and plasticity in relation to child age
    Role: Principal Investigator
  3. U19AI095261 (LUSTER, ANDREW D) Aug 5, 2011 - Jul 31, 2016
    NIH/NIAID
    T cell effector and regulatory mechanisms in asthma and food allergy
    Role: Co-Principal Investigator
  4. R01AI081845 (SHREFFLER, WAYNE G) Jun 11, 2010 - May 31, 2015
    NIH/NIAID
    Mechanisms of Clinical Reactivity or Tolerance to Mouse Allergen
    Role: Principal Investigator
  5. K08AI067722 (SHREFFLER, WAYNE G) Sep 12, 2009 - Nov 1, 2009
    NIH/NIAID
    Mechanisms of peanut (A. hypogaea) glycan adjuvanticity.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Martin VM, Virkud YV, Phadke NA, Su KW, Seay H, Atkins MR, Keet C, Shreffler WG, Yuan Q. Increased IgE-Mediated Food Allergy With Food Protein-Induced Allergic Proctocolitis. Pediatrics. 2020 09; 146(3). PMID: 32855350.
    Citations:    Fields:    Translation:Humans
  2. Fleischer DM, Shreffler WG, Campbell DE, Green TD, Anvari S, Assa'ad A, Bégin P, Beyer K, Bird JA, Brown-Whitehorn T, Byrne A, Chan ES, Cheema A, Chinthrajah S, Chong HJ, Davis CM, Ford LS, Gagnon R, Greenhawt M, Hourihane JO, Jones SM, Kim EH, Lange L, Lanser BJ, Leonard S, Mahler V, Maronna A, Nowak-Wegrzyn A, Oriel RC, O'Sullivan M, Petroni D, Pongracic JA, Prescott SL, Schneider LC, Smith P, Staab D, Sussman G, Wood R, Yang WH, Lambert R, Peillon A, Bois T, Sampson HA. Long-term, open-label extension study of the efficacy and safety of epicutaneous immunotherapy for peanut allergy in children: PEOPLE 3-year results. J Allergy Clin Immunol. 2020 Oct; 146(4):863-874. PMID: 32659313.
    Citations: 1     Fields:    
  3. Esteban CA, Shreffler WG, Virkud YV, Pistiner M. Oral food challenge outcomes in children under 3 years of age. J Allergy Clin Immunol Pract. 2020 Nov - Dec; 8(10):3653-3656.e3. PMID: 32603899.
    Citations:    Fields:    
  4. Pepper AN, Assa'ad A, Blaiss M, Brown E, Chinthrajah S, Ciaccio C, Fasano MB, Gupta R, Hong N, Lang D, Mahr T, Malawer E, Roach A, Shreffler W, Sicherer S, Vickers K, Vickery BP, Wasserman R, Yates K, Casale TB. Consensus report from the Food Allergy Research & Education (FARE) 2019 Oral Immunotherapy for Food Allergy Summit. J Allergy Clin Immunol. 2020 Aug; 146(2):244-249. PMID: 32505612.
    Citations:    Fields:    
  5. Shade KC, Conroy ME, Washburn N, Kitaoka M, Huynh DJ, Laprise E, Patil SU, Shreffler WG, Anthony RM. Sialylation of immunoglobulin E is a determinant of allergic pathogenicity. Nature. 2020 06; 582(7811):265-270. PMID: 32499653.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Su KW, Patil SU, Stockbridge JL, Martin VM, Virkud YV, Huang JL, Shreffler WG, Yuan Q. Food aversion and poor weight gain in food protein-induced enterocolitis syndrome: A retrospective study. J Allergy Clin Immunol. 2020 May; 145(5):1430-1437.e11. PMID: 31940468.
    Citations: 1     Fields:    
  7. Martin VM, Virkud YV, Seay H, Hickey A, Ndahayo R, Rosow R, Southwick C, Elkort M, Gupta B, Kramer E, Pronchick T, Reuter S, Keet C, Su KW, Shreffler WG, Yuan Q. Prospective Assessment of Pediatrician-Diagnosed Food Protein-Induced Allergic Proctocolitis by Gross or Occult Blood. J Allergy Clin Immunol Pract. 2020 May; 8(5):1692-1699.e1. PMID: 31917366.
    Citations: 1     Fields:    
  8. Shreffler WG. Promise of personalized medicine. Ann Allergy Asthma Immunol. 2019 12; 123(6):534. PMID: 31761013.
    Citations:    Fields:    Translation:Humans
  9. Tu AA, Gierahn TM, Monian B, Morgan DM, Mehta NK, Ruiter B, Shreffler WG, Shalek AK, Love JC. TCR sequencing paired with massively parallel 3' RNA-seq reveals clonotypic T cell signatures. Nat Immunol. 2019 12; 20(12):1692-1699. PMID: 31745340.
    Citations: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  10. Ruiter B, Smith NP, Monian B, Tu AA, Fleming E, Virkud YV, Patil SU, Whittaker CA, Love JC, Shreffler WG. Expansion of the CD4+ effector T-cell repertoire characterizes peanut-allergic patients with heightened clinical sensitivity. J Allergy Clin Immunol. 2020 01; 145(1):270-282. PMID: 31654649.
    Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
  11. Westerhout J, Baumert JL, Blom WM, Allen KJ, Ballmer-Weber B, Crevel RWR, Dubois AEJ, Fernández-Rivas M, Greenhawt MJ, Hourihane JO, Koplin JJ, Kruizinga AG, Le TM, Sampson HA, Shreffler WG, Turner PJ, Taylor SL, Houben GF, Remington BC. Deriving individual threshold doses from clinical food challenge data for population risk assessment of food allergens. J Allergy Clin Immunol. 2019 11; 144(5):1290-1309. PMID: 31445097.
    Citations:    Fields:    Translation:HumansPHPublic Health
  12. Patil SU, Steinbrecher J, Calatroni A, Smith N, Ma A, Ruiter B, Virkud Y, Schneider M, Shreffler WG. Early decrease in basophil sensitivity to Ara h 2 precedes sustained unresponsiveness after peanut oral immunotherapy. J Allergy Clin Immunol. 2019 11; 144(5):1310-1319.e4. PMID: 31377342.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  13. Liao S, Patil SU, Shreffler WG, Dreskin SC, Chen X. Human monoclonal antibodies to Ara h 2 inhibit allergen-induced, IgE-mediated cell activation. Clin Exp Allergy. 2019 08; 49(8):1154-1157. PMID: 31134696.
    Citations:    Fields:    Translation:HumansCells
  14. Virkud YV, Chen YC, Stieb ES, Alejos AR, Renton N, Shreffler WG, Hesterberg PE. Analysis of Oral Food Challenge Outcomes in IgE-Mediated Food Allergies to Almond in a Large Cohort. J Allergy Clin Immunol Pract. 2019 Sep - Oct; 7(7):2359-2368.e3. PMID: 30974209.
    Citations: 1     Fields:    Translation:HumansAnimals
  15. Deak PE, Kim B, Abdul Qayum A, Shin J, Vitalpur G, Kloepfer KM, Turner MJ, Smith N, Shreffler WG, Kiziltepe T, Kaplan MH, Bilgicer B. Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):8966-8974. PMID: 30962381.
    Citations:    Fields:    Translation:HumansAnimalsCells
  16. Jiménez-Saiz R, Ellenbogen Y, Bruton K, Spill P, Sommer DD, Lima H, Waserman S, Patil SU, Shreffler WG, Jordana M. Human BCR analysis of single-sorted, putative IgE+ memory B cells in food allergy. J Allergy Clin Immunol. 2019 07; 144(1):336-339.e6. PMID: 30959060.
    Citations: 5     Fields:    Translation:HumansCells
  17. Fleischer DM, Greenhawt M, Sussman G, Bégin P, Nowak-Wegrzyn A, Petroni D, Beyer K, Brown-Whitehorn T, Hebert J, Hourihane JO, Campbell DE, Leonard S, Chinthrajah RS, Pongracic JA, Jones SM, Lange L, Chong H, Green TD, Wood R, Cheema A, Prescott SL, Smith P, Yang W, Chan ES, Byrne A, Assa'ad A, Bird JA, Kim EH, Schneider L, Davis CM, Lanser BJ, Lambert R, Shreffler W. Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial. JAMA. 2019 03 12; 321(10):946-955. PMID: 30794314.
    Citations: 14     Fields:    Translation:HumansAnimalsCTClinical Trials
  18. Vickery BP, Ebisawa M, Shreffler WG, Wood RA. Current and Future Treatment of Peanut Allergy. J Allergy Clin Immunol Pract. 2019 02; 7(2):357-365. PMID: 30717866.
    Citations: 3     Fields:    Translation:Humans
  19. Vickery BP, Vereda A, Casale TB, Beyer K, du Toit G, Hourihane JO, Jones SM, Shreffler WG, Marcantonio A, Zawadzki R, Sher L, Carr WW, Fineman S, Greos L, Rachid R, Ibáñez MD, Tilles S, Assa’ad AH, Nilsson C, Rupp N, Welch MJ, Sussman G, Chinthrajah S, Blumchen K, Sher E, Spergel JM, Leickly FE, Zielen S, Wang J, Sanders GM, Wood RA, Cheema A, Bindslev-Jensen C, Leonard S, Kachru R, Johnston DT, Hampel FC, Kim EH, Anagnostou A, Pongracic JA, Ben-Shoshan M, Sharma HP, Stillerman A, Windom HH, Yang WH, Muraro A, Zubeldia JM, Sharma V, Dorsey MJ, Chong HJ, Ohayon J, Bird JA, Carr TF, Siri D, Fernández-Rivas M, Jeong DK, Fleischer DM, Lieberman JA, Dubois AEJ, Tsoumani M, Ciaccio CE, Portnoy JM, Mansfield LE, Fritz SB, Lanser BJ, Matz J, Oude Elberink HNG, Varshney P, Dilly SG, Adelman DC, Burks AW. AR101 Oral Immunotherapy for Peanut Allergy. N Engl J Med. 2018 Nov 22; 379(21):1991-2001. PMID: 30449234.
    Citations: 27     Fields:    Translation:HumansAnimalsCTClinical Trials
  20. Virkud YV, Wang J, Shreffler WG. Enhancing the Safety and Efficacy of Food Allergy Immunotherapy: a Review of Adjunctive Therapies. Clin Rev Allergy Immunol. 2018 Oct; 55(2):172-189. PMID: 29968170.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. Grant T, Dantzer J, Keet C, Peng R, Paigen BJ, Krevans M, Hagberg K, Curtin-Brosnan J, Shreffler W, Matsui EC. Physician-diagnosed eczema is an independent risk factor for incident mouse skin test sensitization in adults. Allergy Asthma Proc. 2018 Jul 01; 39(4):311-315. PMID: 30111442.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  22. Patil SU, Shreffler WG. Novel vaccines: Technology and development. J Allergy Clin Immunol. 2019 03; 143(3):844-851. PMID: 29970235.
    Citations:    Fields:    Translation:HumansAnimals
  23. Vimalathas P, Farris A, Letner D, Deshpande V, Yajnik V, Shreffler W, Garber J. Integrin aM activation and upregulation on esophageal eosinophils and periostin-mediated eosinophil survival in eosinophilic esophagitis. Immunol Cell Biol. 2018 04; 96(4):426-438. PMID: 29424023.
    Citations: 1     Fields:    Translation:HumansCells
  24. Shreffler WG, Baumert JL, Remington BC, Koppelman SJ, Dinakar C, Fleischer DM, Kim E, Tilles SA, Spergel JM. The importance of reducing risk in peanut allergy: Current and future therapies. Ann Allergy Asthma Immunol. 2018 02; 120(2):124-127. PMID: 29289463.
    Citations: 2     Fields:    Translation:Humans
  25. Sampson HA, Shreffler WG, Yang WH, Sussman GL, Brown-Whitehorn TF, Nadeau KC, Cheema AS, Leonard SA, Pongracic JA, Sauvage-Delebarre C, Assa'ad AH, de Blay F, Bird JA, Tilles SA, Boralevi F, Bourrier T, Hébert J, Green TD, Gerth van Wijk R, Knulst AC, Kanny G, Schneider LC, Kowalski ML, Dupont C. Effect of Varying Doses of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Exposure Among Patients With Peanut Sensitivity: A Randomized Clinical Trial. JAMA. 2017 11 14; 318(18):1798-1809. PMID: 29136445.
    Citations: 23     Fields:    Translation:HumansAnimalsCTClinical Trials
  26. Waserman S, Shreffler W, Jordana M. Probiotics and oral immunotherapy for peanut allergy. Lancet Child Adolesc Health. 2017 Nov; 1(3):e1. PMID: 30169173.
    Citations:    Fields:    
  27. Newton AN, Davis M, Koehler K, Shreffler W, Ahluwalia S, Metwali N, Thorne PS, Paigen BJ, Matsui EC. Atopy as a Modifier of the Relationships Between Endotoxin Exposure and Symptoms Among Laboratory Animal Workers. Ann Work Expo Health. 2017 Oct 01; 61(8):1024-1028. PMID: 29028247.
    Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
  28. Santos AF, Shreffler WG. Road map for the clinical application of the basophil activation test in food allergy. Clin Exp Allergy. 2017 Sep; 47(9):1115-1124. PMID: 28618090.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  29. Patil SU, Calatroni A, Schneider M, Steinbrecher J, Smith N, Washburn C, Ma A, Shreffler WG. Data-driven programmatic approach to analysis of basophil activation tests. Cytometry B Clin Cytom. 2018 07; 94(4):667-673. PMID: 28618453.
    Citations: 1     Fields:    Translation:Humans
  30. Hourihane JO, Allen KJ, Shreffler WG, Dunngalvin G, Nordlee JA, Zurzolo GA, Dunngalvin A, Gurrin LC, Baumert JL, Taylor SL. Peanut Allergen Threshold Study (PATS): Novel single-dose oral food challenge study to validate eliciting doses in children with peanut allergy. J Allergy Clin Immunol. 2017 May; 139(5):1583-1590. PMID: 28238744.
    Citations: 4     Fields:    Translation:HumansAnimals
  31. Gern JE, Calatroni A, Jaffee KF, Lynn H, Dresen A, Cruikshank WW, Lederman HM, Sampson HA, Shreffler W, Bacharier LB, Gergen PJ, Gold DR, Kattan M, O'Connor GT, Sandel MT, Wood RA, Bloomberg GR. Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy. J Allergy Clin Immunol. 2017 Sep; 140(3):836-844.e7. PMID: 28089873.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  32. Martin VJ, Shreffler WG, Yuan Q. Presumed Allergic Proctocolitis Resolves with Probiotic Monotherapy: A Report of 4 Cases. Am J Case Rep. 2016 Aug 29; 17:621-4. PMID: 27568925.
    Citations: 2     Fields:    Translation:HumansCells
  33. Kakumanu S, Jaffee K, Visness CM, Dresen A, Burger M, Witter FR, O'Connor GT, Cruikshank WW, Shreffler WG, Bacharier LB, Gern JE. The influence of atopy and asthma on immune responses in inner-city adults. Immun Inflamm Dis. 2016 Mar; 4(1):80-90. PMID: 27042305.
    Citations: 1     Fields:    
  34. Gruchalla RS, Sampson HA, Liu AH, Shreffler W, Wallace PK, Togias A, David G, Calatroni A, LeBeau P. Effects of omalizumab on T lymphocyte function in inner-city children with asthma. Pediatr Allergy Immunol. 2016 05; 27(3):328-31. PMID: 26573086.
    Citations: 3     Fields:    Translation:HumansCells
  35. Berin MC, Shreffler WG. Mechanisms Underlying Induction of Tolerance to Foods. Immunol Allergy Clin North Am. 2016 Feb; 36(1):87-102. PMID: 26617229.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  36. Hoffmann HJ, Santos AF, Mayorga C, Nopp A, Eberlein B, Ferrer M, Rouzaire P, Ebo DG, Sabato V, Sanz ML, Pecaric-Petkovic T, Patil SU, Hausmann OV, Shreffler WG, Korosec P, Knol EF. The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease. Allergy. 2015 Nov; 70(11):1393-405. PMID: 26198455.
    Citations: 45     Fields:    Translation:HumansCells
  37. Leung J, Mehrzad R, Hundal NV, Alejos A, Hesterberg PE, Katz AJ, Yuan Q, Shreffler WG. Longitudinal Perspective on Managing Refractory Eosinophilic Esophagitis. J Allergy Clin Immunol Pract. 2015 Nov-Dec; 3(6):951-6. PMID: 26342740.
    Citations: 6     Fields:    Translation:Humans
  38. Ruiter B, Patil SU, Shreffler WG. Vitamins A and D have antagonistic effects on expression of effector cytokines and gut-homing integrin in human innate lymphoid cells. Clin Exp Allergy. 2015 Jul; 45(7):1214-25. PMID: 25959810.
    Citations: 16     Fields:    Translation:HumansCells
  39. Patil SU, Ogunniyi AO, Calatroni A, Tadigotla VR, Ruiter B, Ma A, Moon J, Love JC, Shreffler WG. Peanut oral immunotherapy transiently expands circulating Ara h 2-specific B cells with a homologous repertoire in unrelated subjects. J Allergy Clin Immunol. 2015 Jul; 136(1):125-134.e12. PMID: 25985925.
    Citations: 18     Fields:    Translation:HumansCells
  40. Patil SU, Shreffler WG. BATting above average: basophil activation testing for peanut allergy. J Allergy Clin Immunol. 2014 Sep; 134(3):653-4. PMID: 25171867.
    Citations: 2     Fields:    Translation:Humans
  41. Keet C, Radano MC, Shreffler W. Re: Reply to Lifschitz. J Allergy Clin Immunol Pract. 2014 Sep-Oct; 2(5):643-4. PMID: 25213070.
    Citations:    Fields:    Translation:Humans
  42. Radano MC, Yuan Q, Katz A, Fleming JT, Kubala S, Shreffler W, Keet CA. Cesarean section and antibiotic use found to be associated with eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2014 Jul-Aug; 2(4):475-477.e1. PMID: 25017541.
    Citations: 14     Fields:    Translation:HumansPHPublic Health
  43. Tabatabaei N, Kang D, Wu T, Kim M, Carruth RW, Leung J, Sauk JS, Shreffler W, Yuan Q, Katz A, Nishioka NS, Tearney GJ. Tethered confocal endomicroscopy capsule for diagnosis and monitoring of eosinophilic esophagitis. Biomed Opt Express. 2013 Dec 13; 5(1):197-207. PMID: 24466487.
    Citations: 13     
  44. Kubala SA, Patil SU, Shreffler WG, Hurley BP. Pathogen induced chemo-attractant hepoxilin A3 drives neutrophils, but not eosinophils across epithelial barriers. Prostaglandins Other Lipid Mediat. 2014 Jan; 108:1-8. PMID: 24315875.
    Citations: 3     Fields:    Translation:HumansCells
  45. Keet CA, Shreffler WG, Peng RD, Matsui W, Matsui EC. Associations between serum folate and vitamin D levels and incident mouse sensitization in adults. J Allergy Clin Immunol. 2014 Feb; 133(2):399-404. PMID: 24290285.
    Citations: 3     Fields:    Translation:HumansAnimals
  46. Leung J, Hundal NV, Katz AJ, Shreffler WG, Yuan Q, Butterworth CA, Hesterberg PE. Tolerance of baked milk in patients with cow's milk-mediated eosinophilic esophagitis. J Allergy Clin Immunol. 2013 Nov; 132(5):1215-1216.e1. PMID: 24084076.
    Citations: 16     Fields:    Translation:HumansAnimals
  47. Zurzolo GA, Allen KJ, Taylor SL, Shreffler WG, Baumert JL, Tang ML, Gurrin LC, Mathai ML, Nordlee JA, Dunngalvin A, Hourihane JO. Peanut Allergen Threshold Study (PATS): validation of eliciting doses using a novel single-dose challenge protocol. Allergy Asthma Clin Immunol. 2013 Sep 12; 9(1):35. PMID: 24028324.
    Citations: 5     
  48. Islam SA, Ling MF, Leung J, Shreffler WG, Luster AD. Identification of human CCR8 as a CCL18 receptor. J Exp Med. 2013 Sep 23; 210(10):1889-98. PMID: 23999500.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  49. Katz A, Virk Hundal N, Yuan Q, Shreffler W. Cow's milk allergy: a new approach needed? J Pediatr. 2013 Sep; 163(3):620-2. PMID: 23809049.
    Citations: 2     Fields:    Translation:Humans
  50. Ruiter B, Shreffler WG. Innate immunostimulatory properties of allergens and their relevance to food allergy. Semin Immunopathol. 2012 Sep; 34(5):617-32. PMID: 22886110.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  51. Thyagarajan A, Jones SM, Calatroni A, Pons L, Kulis M, Woo CS, Kamalakannan M, Vickery BP, Scurlock AM, Wesley Burks A, Shreffler WG. Evidence of pathway-specific basophil anergy induced by peanut oral immunotherapy in peanut-allergic children. Clin Exp Allergy. 2012 Aug; 42(8):1197-205. PMID: 22805467.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  52. Ford LS, Bloom KA, Nowak-Wegrzyn AH, Shreffler WG, Masilamani M, Sampson HA. Basophil reactivity, wheal size, and immunoglobulin levels distinguish degrees of cow's milk tolerance. J Allergy Clin Immunol. 2013 Jan; 131(1):180-6.e1-3. PMID: 22819512.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  53. Burks AW, Jones SM, Wood RA, Fleischer DM, Sicherer SH, Lindblad RW, Stablein D, Henning AK, Vickery BP, Liu AH, Scurlock AM, Shreffler WG, Plaut M, Sampson HA. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med. 2012 Jul 19; 367(3):233-43. PMID: 22808958.
    Citations: 148     Fields:    Translation:Humans
  54. Ruiter B, Shreffler WG. The role of dendritic cells in food allergy. J Allergy Clin Immunol. 2012 Apr; 129(4):921-8. PMID: 22464669.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  55. Masilamani M, Commins S, Shreffler W. Determinants of food allergy. Immunol Allergy Clin North Am. 2012 Feb; 32(1):11-33. PMID: 22244230.
    Citations: 8     Fields:    Translation:HumansAnimalsPHPublic Health
  56. Patil SU, Shreffler WG. Immunology in the Clinic Review Series; focus on allergies: basophils as biomarkers for assessing immune modulation. Clin Exp Immunol. 2012 Jan; 167(1):59-66. PMID: 22132885.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  57. Rosenfeld L, Shreffler W, Bardina L, Niggemann B, Wahn U, Sampson HA, Beyer K. Walnut allergy in peanut-allergic patients: significance of sequential epitopes of walnut homologous to linear epitopes of Ara h 1, 2 and 3 in relation to clinical reactivity. Int Arch Allergy Immunol. 2012; 157(3):238-45. PMID: 22042002.
    Citations: 4     Fields:    Translation:HumansAnimals
  58. Shreffler WG, Radano M. Food allergy and complementary feeding. Nestle Nutr Workshop Ser Pediatr Program. 2011; 68:141-9; discussion 150-2. PMID: 22044897.
    Citations: 2     Fields:    Translation:HumansAnimals
  59. Peng RD, Paigen B, Eggleston PA, Hagberg KA, Krevans M, Curtin-Brosnan J, Benson C, Shreffler WG, Matsui EC. Both the variability and level of mouse allergen exposure influence the phenotype of the immune response in workers at a mouse facility. J Allergy Clin Immunol. 2011 Aug; 128(2):390-396.e7. PMID: 21696812.
    Citations: 12     Fields:    Translation:HumansAnimalsPHPublic Health
  60. Shreffler WG. Microarrayed recombinant allergens for diagnostic testing. J Allergy Clin Immunol. 2011 Apr; 127(4):843-9; quiz 850-1. PMID: 21458654.
    Citations: 21     Fields:    Translation:HumansAnimals
  61. Kim EH, Bird JA, Kulis M, Laubach S, Pons L, Shreffler W, Steele P, Kamilaris J, Vickery B, Burks AW. Sublingual immunotherapy for peanut allergy: clinical and immunologic evidence of desensitization. J Allergy Clin Immunol. 2011 Mar; 127(3):640-6.e1. PMID: 21281959.
    Citations: 100     Fields:    Translation:HumansCTClinical Trials
  62. Ditto AM, Neilsen CV, Neerukonda S, Shreffler WG, Bryce PJ. Clinical reactivity to raw peanut correlates with IgE binding to conformational epitopes of Ara h 1: a case report. Allergy. 2010 Nov; 65(11):1485-6. PMID: 20412153.
    Citations: 3     Fields:    Translation:HumansCells
  63. Vereda A, Andreae DA, Lin J, Shreffler WG, Ibañez MD, Cuesta-Herranz J, Bardina L, Sampson HA. Identification of IgE sequential epitopes of lentil (Len c 1) by means of peptide microarray immunoassay. J Allergy Clin Immunol. 2010 Sep; 126(3):596-601.e1. PMID: 20816193.
    Citations: 7     Fields:    Translation:HumansAnimals
  64. Blumchen K, Ulbricht H, Staden U, Dobberstein K, Beschorner J, de Oliveira LC, Shreffler WG, Sampson HA, Niggemann B, Wahn U, Beyer K. Oral peanut immunotherapy in children with peanut anaphylaxis. J Allergy Clin Immunol. 2010 Jul; 126(1):83-91.e1. PMID: 20542324.
    Citations: 95     Fields:    Translation:Humans
  65. Sicherer SH, Wood RA, Stablein D, Burks AW, Liu AH, Jones SM, Fleischer DM, Leung DY, Grishin A, Mayer L, Shreffler W, Lindblad R, Sampson HA. Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy. J Allergy Clin Immunol. 2010 May; 125(5):1077-1083.e8. PMID: 20451041.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  66. Wang J, Lin J, Bardina L, Goldis M, Nowak-Wegrzyn A, Shreffler WG, Sampson HA. Correlation of IgE/IgG4 milk epitopes and affinity of milk-specific IgE antibodies with different phenotypes of clinical milk allergy. J Allergy Clin Immunol. 2010 Mar; 125(3):695-702, 702.e1-702.e6. PMID: 20226304.
    Citations: 48     Fields:    Translation:HumansCells
  67. Järvinen KM, Amalanayagam S, Shreffler WG, Noone S, Sicherer SH, Sampson HA, Nowak-Wegrzyn A. Epinephrine treatment is infrequent and biphasic reactions are rare in food-induced reactions during oral food challenges in children. J Allergy Clin Immunol. 2009 Dec; 124(6):1267-72. PMID: 20004784.
    Citations: 18     Fields:    Translation:Humans
  68. Lin J, Bardina L, Shreffler WG, Andreae DA, Ge Y, Wang J, Bruni FM, Fu Z, Han Y, Sampson HA. Development of a novel peptide microarray for large-scale epitope mapping of food allergens. J Allergy Clin Immunol. 2009 Aug; 124(2):315-22, 322.e1-3. PMID: 19577281.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  69. Jones SM, Pons L, Roberts JL, Scurlock AM, Perry TT, Kulis M, Shreffler WG, Steele P, Henry KA, Adair M, Francis JM, Durham S, Vickery BP, Zhong X, Burks AW. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol. 2009 Aug; 124(2):292-300, 300.e1-97. PMID: 19577283.
    Citations: 189     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  70. Gern JE, Visness CM, Gergen PJ, Wood RA, Bloomberg GR, O'Connor GT, Kattan M, Sampson HA, Witter FR, Sandel MT, Shreffler WG, Wright RJ, Arbes SJ, Busse WW. The Urban Environment and Childhood Asthma (URECA) birth cohort study: design, methods, and study population. BMC Pulm Med. 2009 May 08; 9:17. PMID: 19426496.
    Citations: 40     Fields:    Translation:Humans
  71. Wanich N, Nowak-Wegrzyn A, Sampson HA, Shreffler WG. Allergen-specific basophil suppression associated with clinical tolerance in patients with milk allergy. J Allergy Clin Immunol. 2009 Apr; 123(4):789-94.e20. PMID: 19348919.
    Citations: 40     Fields:    Translation:HumansCells
  72. Shreffler WG. The perfectly potent peanut. J Allergy Clin Immunol. 2009 Feb; 123(2):352-3. PMID: 19203659.
    Citations:    Fields:    Translation:HumansAnimals
  73. Lin J, Bardina L, Shreffler WG. Microarrayed allergen molecules for diagnostics of allergy. Methods Mol Biol. 2009; 524:259-72. PMID: 19377951.
    Citations: 4     Fields:    Translation:Humans
  74. Shreffler WG, Wanich N, Moloney M, Nowak-Wegrzyn A, Sampson HA. Association of allergen-specific regulatory T cells with the onset of clinical tolerance to milk protein. J Allergy Clin Immunol. 2009 Jan; 123(1):43-52.e7. PMID: 19130927.
    Citations: 66     Fields:    Translation:HumansCells
  75. Moloney M, Shreffler WG. Basic science for the practicing physician: flow cytometry and cell sorting. Ann Allergy Asthma Immunol. 2008 Nov; 101(5):544-9. PMID: 19055210.
    Citations: 4     Fields:    Translation:Humans
  76. Lemon-Mulé H, Sampson HA, Sicherer SH, Shreffler WG, Noone S, Nowak-Wegrzyn A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol. 2008 Nov; 122(5):977-983.e1. PMID: 18851876.
    Citations: 85     Fields:    Translation:Humans
  77. Cerecedo I, Zamora J, Shreffler WG, Lin J, Bardina L, Dieguez MC, Wang J, Muriel A, de la Hoz B, Sampson HA. Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray-based immunoassay. J Allergy Clin Immunol. 2008 Sep; 122(3):589-94. PMID: 18774394.
    Citations: 33     Fields:    Translation:HumansCells
  78. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, Shreffler WG, Noone S, Wanich N, Sampson HA. Tolerance to extensively heated milk in children with cow's milk allergy. J Allergy Clin Immunol. 2008 Aug; 122(2):342-7, 347.e1-2. PMID: 18620743.
    Citations: 93     Fields:    Translation:HumansAnimals
  79. Berin MC, Shreffler WG. T(H)2 adjuvants: implications for food allergy. J Allergy Clin Immunol. 2008 Jun; 121(6):1311-20; quiz 1321-2. PMID: 18539190.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  80. Hyman SJ, Shreffler WG, Rapaport R. Type 1 diabetes, autoimmune thyroid disease, and chronic urticaria. Pediatr Diabetes. 2008 Oct; 9(5):508-11. PMID: 18466206.
    Citations: 2     Fields:    Translation:Humans
  81. Flinterman AE, Knol EF, Lencer DA, Bardina L, den Hartog Jager CF, Lin J, Pasmans SG, Bruijnzeel-Koomen CA, Sampson HA, van Hoffen E, Shreffler WG. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol. 2008 Mar; 121(3):737-743.e10. PMID: 18234310.
    Citations: 41     Fields:    Translation:HumansAnimals
  82. Shreffler WG, Visness CM, Burger M, Cruikshank WW, Lederman HM, de la Morena M, Grindle K, Calatroni A, Sampson HA, Gern JE. Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study. BMC Immunol. 2006 Dec 12; 7:29. PMID: 17156490.
    Citations: 16     Fields:    Translation:HumansCells
  83. Shreffler WG, Castro RR, Kucuk ZY, Charlop-Powers Z, Grishina G, Yoo S, Burks AW, Sampson HA. The major glycoprotein allergen from Arachis hypogaea, Ara h 1, is a ligand of dendritic cell-specific ICAM-grabbing nonintegrin and acts as a Th2 adjuvant in vitro. J Immunol. 2006 Sep 15; 177(6):3677-85. PMID: 16951327.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  84. Li H, Nowak-Wegrzyn A, Charlop-Powers Z, Shreffler W, Chehade M, Thomas S, Roda G, Dahan S, Sperber K, Berin MC. Transcytosis of IgE-antigen complexes by CD23a in human intestinal epithelial cells and its role in food allergy. Gastroenterology. 2006 Jul; 131(1):47-58. PMID: 16831589.
    Citations: 26     Fields:    Translation:HumansCells
  85. Shreffler WG, Charlop-Powers Z, Sicherer SH. Lack of association of HLA class II alleles with peanut allergy. Ann Allergy Asthma Immunol. 2006 Jun; 96(6):865-9. PMID: 16802776.
    Citations: 15     Fields:    Translation:Humans
  86. Shreffler WG. Evaluation of basophil activation in food allergy: present and future applications. Curr Opin Allergy Clin Immunol. 2006 Jun; 6(3):226-33. PMID: 16670519.
    Citations: 17     Fields:    Translation:HumansCells
  87. Knight AK, Shreffler WG, Sampson HA, Sicherer SH, Noone S, Mofidi S, Nowak-Wegrzyn A. Skin prick test to egg white provides additional diagnostic utility to serum egg white-specific IgE antibody concentration in children. J Allergy Clin Immunol. 2006 Apr; 117(4):842-7. PMID: 16630943.
    Citations: 11     Fields:    Translation:Humans
  88. Shreffler WG, Lencer DA, Bardina L, Sampson HA. IgE and IgG4 epitope mapping by microarray immunoassay reveals the diversity of immune response to the peanut allergen, Ara h 2. J Allergy Clin Immunol. 2005 Oct; 116(4):893-9. PMID: 16210066.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  89. Shreffler WG, Beyer K, Chu TH, Burks AW, Sampson HA. Microarray immunoassay: association of clinical history, in vitro IgE function, and heterogeneity of allergenic peanut epitopes. J Allergy Clin Immunol. 2004 Apr; 113(4):776-82. PMID: 15100687.
    Citations: 61     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.