Wayne G Shreffler, M.D., Ph.D.
Title Associate Professor of Pediatrics Institution Massachusetts General Hospital Address Massachusetts General Hospital
Pediatric-Allergy Section
55 Fruit St
Boston MA 02114
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Overview
Our research program involves a combination of approaches, primarily with human samples and often in conjunction with clinical interventional or observational studies, to interrogate both the innate and adaptive immune responses to major dietary and aeroallergens.
Working together with leading clinical investigators around the world as part of the Consortium for Food Allergy Research and the Inner City Asthma Consortium and the newly established Food Allergy Research Center at MGH, we are adapting the use of polychromatic flow cytometry and peptide microarray-based humoral immune profiling and systems biology approaches to uniquely characterize the phenotype and function of allergen-specific T and B cell responses and the regulations of effector cells in pediatric food allergy and asthma.
Equally important is the effort to understand the mechanisms that influence early immune fate decisions to allergens and the intrinsic properties of those allergens that facilitate an allergic response and we are studying this in human and murine model systems.
Research
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R13AI150089
(SHREFFLER, WAYNE G)
Dec 12, 2019 - Nov 30, 2020
2020 Food Allergy Gordon Research Conference and Gordon Research Seminar
Role: Principal Investigator
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UM1AI130934
(SHREFFLER, WAYNE G)
Mar 1, 2017 - Feb 28, 2022
Immune progression and plasticity in relation to child age
Role: Principal Investigator
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U19AI095261
(LUSTER, ANDREW D)
Aug 5, 2011 - Jul 31, 2016
T cell effector and regulatory mechanisms in asthma and food allergy
Role: Co-Principal Investigator
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R01AI081845
(SHREFFLER, WAYNE G)
Jun 11, 2010 - Nov 30, 2016
Mechanisms of Clinical Reactivity or Tolerance to Mouse Allergen
Role: Principal Investigator
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R03AI079544
(SHREFFLER, WAYNE G)
Sep 15, 2008 - Feb 28, 2011
Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
Role: Principal Investigator
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K08AI067722
(SHREFFLER, WAYNE G)
Sep 15, 2007 - Jul 31, 2010
Mechanisms of peanut (A. hypogaea) glycan adjuvanticity.
Role: Principal Investigator
Bibliographic
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