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Wayne G Shreffler, M.D., Ph.D.

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Overview
Our research program involves a combination of approaches, primarily with human samples and often in conjunction with clinical interventional or observational studies, to interrogate both the innate and adaptive immune responses to major dietary and aeroallergens.

Working together with leading clinical investigators around the world as part of the Consortium for Food Allergy Research and the Inner City Asthma Consortium and the newly established Food Allergy Research Center at MGH, we are adapting the use of polychromatic flow cytometry and peptide microarray-based humoral immune profiling and systems biology approaches to uniquely characterize the phenotype and function of allergen-specific T and B cell responses and the regulations of effector cells in pediatric food allergy and asthma.

Equally important is the effort to understand the mechanisms that influence early immune fate decisions to allergens and the intrinsic properties of those allergens that facilitate an allergic response and we are studying this in human and murine model systems.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13AI150089 (SHREFFLER, WAYNE G) Dec 12, 2019 - Nov 30, 2020
    NIH
    2020 Food Allergy Gordon Research Conference and Gordon Research Seminar
    Role: Principal Investigator
  2. UM1AI130934 (SHREFFLER, WAYNE G) Mar 1, 2017 - Feb 29, 2024
    NIH
    Immune progression and plasticity in relation to child age
    Role: Principal Investigator
  3. U19AI095261 (LUSTER, ANDREW D) Aug 5, 2011 - Jul 31, 2016
    NIH
    T cell effector and regulatory mechanisms in asthma and food allergy
    Role: Co-Principal Investigator
  4. R01AI081845 (SHREFFLER, WAYNE G) Jun 11, 2010 - Nov 30, 2016
    NIH
    Mechanisms of Clinical Reactivity or Tolerance to Mouse Allergen
    Role: Principal Investigator
  5. R03AI079544 (SHREFFLER, WAYNE G) Sep 15, 2008 - Feb 28, 2011
    NIH
    Mechanisms of oral immunotherapy-induced suppression of type I hypersensitivity.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.