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John Nagi Kheir, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dionne A, Kheir JN, Gauvreau K, Triedman JK, Abrams DJ, Alexander ME, DeWitt ES, Mah DY, Walsh EP, Bezzerides VJ. Value of provocative electrophysiology testing in the management of pediatric patients after congenital heart surgery. Pacing Clin Electrophysiol. 2020 Apr 24. PMID: 32329521.
    Citations:    
  2. Sinha AM, van den Bosch SJ, Pozerski K, Zhou L, Kheir JN. Development of a Respiratory Support Score as a Visualization Tool in Intensive Care. Respir Care. 2020 Mar 31. PMID: 32234769.
    Citations:    
  3. Thatte N, Zhou L, Kheir JN. Impact of the superior cavopulmonary anastomosis on cerebral oxygenation. Cardiol Young. 2020 Apr; 30(4):585-587. PMID: 32172701.
    Citations:    
  4. Dionne A, Kheir JN, Sleeper LA, Esch JJ, Breitbart RE. Value of Troponin Testing for Detection of Heart Disease in Previously Healthy Children. J Am Heart Assoc. 2020 Feb 18; 9(4):e012897. PMID: 32067577.
    Citations:    
  5. Gagnon MH, Kussman BD, Zhou L, DiNardo JA, Kheir JN. Sensitivity of a Next-Generation NIRS Device to Detect Low Mixed Venous Oxyhemoglobin Saturations in the Single Ventricle Population. Anesth Analg. 2020 Jan 20. PMID: 31985496.
    Citations:    
  6. Weixler VHM, Zurakowski D, Kheir J, Guariento A, Kaza AK, Baird CW, Del Nido PJ, Emani SM. Fontan with lateral tunnel is associated with improved survival compared with extracardiac conduit. J Thorac Cardiovasc Surg. 2020 04; 159(4):1480-1491.e2. PMID: 31928823.
    Citations:    
  7. Cole AR, Raza A, Ahmed H, Polizzotti BD, Padera RF, Andrews N, Kheir JN. Safety of inhaled hydrogen gas in healthy mice. Med Gas Res. 2019 Jul-Sep; 9(3):133-138. PMID: 31552876.
    Citations:    
  8. Cole AR, Perry DA, Raza A, Nedder AP, Pollack E, Regan WL, van den Bosch SJ, Polizzotti BD, Yang E, Davila D, Afacan O, Warfield SK, Ou Y, Sefton B, Everett AD, Neil JJ, Lidov HGW, Mayer JE, Kheir JN. Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. JACC Basic Transl Sci. 2019 Apr; 4(2):176-187. PMID: 31061920.
    Citations:    
  9. Kheir JN, DiNardo JA. Reply to Li, J "The Fick principle remains accurate to calculate cardiac output under hyperoxia". Acta Anaesthesiol Scand. 2019 07; 63(6):828. PMID: 30907432.
    Citations:    
  10. Mackin C, DeWitt ES, Black KJ, Tang X, Polizzotti BD, van den Bosch SJ, Alexander ME, Kheir JN. Intravenous Amiodarone and Sotalol Impair Contractility and Cardiac Output, but Procainamide Does Not: A Langendorff Study. J Cardiovasc Pharmacol Ther. 2019 05; 24(3):288-297. PMID: 30497293.
    Citations:    
  11. Peng Y, Li Q, Seekell RR, Kheir JN, Porter TM, Polizzotti BD. Tunable Nonlinear Acoustic Reporters Using Micro- and Nanosized Air Bubbles with Porous Polymeric Hard Shells. ACS Appl Mater Interfaces. 2019 Jan 09; 11(1):7-12. PMID: 30444111.
    Citations:    Fields:    
  12. Peng Y, Kheir JN, Polizzotti BD. Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science. Chemistry. 2018 Dec 17; 24(71):18820-18829. PMID: 29952026.
    Citations:    Fields:    
  13. Mills KI, van den Bosch SJ, Gauvreau K, Allan CK, Thiagarajan RR, Hoganson DM, Baird CW, Nathan M, DiNardo JA, Kheir JN. Physiologic effects of delayed sternal closure following stage 1 palliation. Cardiol Young. 2018 Dec; 28(12):1393-1403. PMID: 30152302.
    Citations:    Fields:    
  14. Perry DA, Thomson LM, Pigula FA, Polizzotti BD, DiNardo JA, Nedder A, Gauvreau K, Kheir JN. Changes in tissue oxygen tension, venous saturation, and Fick-based assessments of cardiac output during hyperoxia. Acta Anaesthesiol Scand. 2019 01; 63(1):93-100. PMID: 30109703.
    Citations:    Fields:    
  15. Seekell RP, Peng Y, Lock AT, Kheir JN, Polizzotti BD. Tunable Polymer Microcapsules for Controlled Release of Therapeutic Gases. Langmuir. 2018 08 07; 34(31):9175-9183. PMID: 29989828.
    Citations:    Fields:    
  16. Nachman E, Clemensen P, Santos K, Cole AR, Polizzotti BD, Hofmann G, Leeman KT, van den Bosch SJ, Kheir JN. A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range. Anesth Analg. 2018 07; 127(1):95-104. PMID: 29505450.
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  17. Hoganson DM, Cigarroa CL, van den Bosch SJ, Sleeper LA, Callahan R, Friedman KG, Baird CW, Quinonez LG, Kaza AK, Emani SE, Kheir JN. Impact of a Composite Valved RV-PA Graft After Stage 1 Palliation. Ann Thorac Surg. 2018 11; 106(5):1452-1459. PMID: 29964021.
    Citations:    Fields:    
  18. Nair AG, Oladunjoye OO, Trenor CC, LaRonde M, van den Bosch SJ, Sleeper LA, VanderPluym C, Emani SM, Kheir JN. An anticoagulation protocol for use after congenital cardiac surgery. J Thorac Cardiovasc Surg. 2018 07; 156(1):343-352.e4. PMID: 29706371.
    Citations: 1     Fields:    
  19. Oladunjoye OO, Sleeper LA, Nair AG, Trenor CC, VanderPluym C, Kheir JN, Emani SM. Partial thromboplastin time is more predictive of bleeding than anti-Xa levels in heparinized pediatric patients after cardiac surgery. J Thorac Cardiovasc Surg. 2018 07; 156(1):332-340.e1. PMID: 29709361.
    Citations:    Fields:    
  20. Kheir JN, Polizzotti BD, DiNardo JA. Use of Oxyhemoglobin Saturation or Oxygen Tension-an Unsolved Question-Reply. JAMA Pediatr. 2018 04 01; 172(4):390-391. PMID: 29404620.
    Citations:    Fields:    
  21. Peng Y, Seekell RP, Cole AR, Lamothe JR, Lock AT, van den Bosch S, Tang X, Kheir JN, Polizzotti BD. Interfacial Nanoprecipitation toward Stable and Responsive Microbubbles and Their Use as a Resuscitative Fluid. Angew Chem Int Ed Engl. 2018 01 26; 57(5):1271-1276. PMID: 29230917.
    Citations:    Fields:    
  22. Cigarroa CL, van den Bosch SJ, Tang X, Gauvreau K, Baird CW, DiNardo JA, Kheir JN. Measurement of Dead Space Fraction Upon ICU Admission Predicts Length of Stay and Clinical Outcomes Following Bidirectional Cavopulmonary Anastomosis. Pediatr Crit Care Med. 2018 01; 19(1):23-31. PMID: 29189669.
    Citations:    Fields:    
  23. Ahmed H, Tang X, Polizzotti B, Gauvreau K, Kellogg M, DiNardo J, Kheir J. Use of Oxyhemoglobin Saturation, Rather Than Oxygen Tension, as a Marker of Oxygenation in Cyanotic Patients. JAMA Pediatr. 2017 10 01; 171(10):1012-1014. PMID: 28828474.
    Citations:    Fields:    
  24. Perry DA, Salvin JW, Romfh P, Chen P, Krishnamurthy K, Thomson LM, Polizzotti BD, McGowan FX, Vakhshoori D, Kheir JN. Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931652.
    Citations: 2     Fields:    Translation:AnimalsCells
  25. Black KJ, Lock AT, Thomson LM, Cole AR, Tang X, Polizzotti BD, Kheir JN. Hemodynamic Effects of Lipid-Based Oxygen Microbubbles via Rapid Intravenous Injection in Rodents. Pharm Res. 2017 Oct; 34(10):2156-2162. PMID: 28685297.
    Citations:    Fields:    Translation:HumansAnimals
  26. Rescoe E, Tang X, Perry DA, Sleeper LA, DiNardo JA, Kussman BD, Kheir JN. Cerebral near-infrared spectroscopy insensitively detects low cerebral venous oxygen saturations after stage 1 palliation. J Thorac Cardiovasc Surg. 2017 09; 154(3):1056-1062. PMID: 28599970.
    Citations:    Fields:    
  27. Smallwood CD, Kheir JN, Walsh BK, Mehta NM. Accuracy of Oxygen Consumption and Carbon Dioxide Elimination Measurements in 2 Breath-by-Breath Devices. Respir Care. 2017 Apr; 62(4):475-480. PMID: 28096476.
    Citations:    Fields:    Translation:Humans
  28. Kheir JN, Polizzotti BD. Reply to Span et al.: Rational design of oxygen microparticles for radiation therapy. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8010. PMID: 27930334.
    Citations: 1     Fields:    Translation:HumansCells
  29. French C, Mills K, Baird C, Santos K, Tang X, Kheir J, Mehta N. 462: BEDSIDE VCO2 AS A GUIDE TO INDIVIDUALIZED ENERGY PRESCRIPTION IN VENTILATED CHILDREN IN THE CICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):192. PMID: 27850102.
    Citations:    
  30. Mills K, French C, Baird C, Santos K, Tang X, Kheir J, Mehta N. 450: SUBOPTIMAL PROTEIN INTAKE MAY PROLONG CICU LENGTH OF STAY AND WORSEN NUTRITIONAL STATUS IN CHILDREN. Crit Care Med. 2016 Dec; 44(12 Suppl 1):189. PMID: 27850090.
    Citations:    
  31. Sinha A, Tang X, Kheir J. 191: QUANTIFYING ICU SUPPORT IN THE CONTEXT OF DISEASE-MATCHED PATIENTS OVER TIME USING PERCENTILE CURVES. Crit Care Med. 2016 Dec; 44(12 Suppl 1):125. PMID: 27849834.
    Citations:    
  32. Mills KI, Kaza AK, Walsh BK, Bond HC, Ford M, Wypij D, Thiagarajan RR, Almodovar MC, Quinonez LG, Baird CW, Emani SE, Pigula FA, DiNardo JA, Kheir JN. Phosphodiesterase Inhibitor-Based Vasodilation Improves Oxygen Delivery and Clinical Outcomes Following Stage 1 Palliation. J Am Heart Assoc. 2016 11 02; 5(11). PMID: 27806964.
    Citations:    Fields:    Translation:Humans
  33. Seekell RP, Lock AT, Peng Y, Cole AR, Perry DA, Kheir JN, Polizzotti BD. Oxygen delivery using engineered microparticles. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12380-12385. PMID: 27791101.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  34. DeWitt ES, Black KJ, Kheir JN. Rodent Working Heart Model for the Study of Myocardial Performance and Oxygen Consumption. J Vis Exp. 2016 08 16; (114). PMID: 27584550.
    Citations:    Fields:    Translation:Animals
  35. DeWitt ES, Black KJ, Thiagarajan RR, DiNardo JA, Colan SD, McGowan FX, Kheir JN. Effects of commonly used inotropes on myocardial function and oxygen consumption under constant ventricular loading conditions. J Appl Physiol (1985). 2016 07 01; 121(1):7-14. PMID: 27150829.
    Citations: 2     Fields:    Translation:Animals
  36. Templin JS, Wylie MC, Kim JD, Kurgansky KE, Gorski G, Kheir J, Zurakowski D, Corfas G, Berde C. Neosaxitoxin in Rat Sciatic Block: Improved Therapeutic Index Using Combinations with Bupivacaine, with and without Epinephrine. Anesthesiology. 2015 Oct; 123(4):886-98. PMID: 26280473.
    Citations: 4     Fields:    Translation:Animals
  37. Walsh BK, Davis MD, Hunt JF, Kheir JN, Smallwood CD, Arnold JH. The effects of lung recruitment maneuvers on exhaled breath condensate pH. J Breath Res. 2015 Sep 03; 9(3):036009. PMID: 26333431.
    Citations: 1     Fields:    Translation:Humans
  38. Thomson LM, Polizzotti BD, McGowan FX, Kheir JN. Manufacture of concentrated, lipid-based oxygen microbubble emulsions by high shear homogenization and serial concentration. J Vis Exp. 2014 May 26; (87). PMID: 24894333.
    Citations: 2     Fields:    
  39. Polizzotti BD, Thomson LM, O'Connell DW, McGowan FX, Kheir JN. Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design. J Biomed Mater Res B Appl Biomater. 2014 Aug; 102(6):1148-56. PMID: 24425069.
    Citations: 3     Fields:    
  40. Kheir JN, Polizzotti BD, Thomson LM, O'Connell DW, Black KJ, Lee RW, Wilking JN, Graham AC, Bell DC, McGowan FX. Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. Adv Healthc Mater. 2013 Aug; 2(8):1131-41. PMID: 23471884.
    Citations: 5     Fields:    Translation:AnimalsCells
  41. Kheir JN, Walsh BK, Smallwood CD, Rettig JS, Thompson JE, Gómez-Laberge C, Wolf GK, Arnold JH. Comparison of 2 lung recruitment strategies in children with acute lung injury. Respir Care. 2013 Aug; 58(8):1280-90. PMID: 23232733.
    Citations: 1     Fields:    Translation:Humans
  42. Wolf GK, Gómez-Laberge C, Kheir JN, Zurakowski D, Walsh BK, Adler A, Arnold JH. Reversal of dependent lung collapse predicts response to lung recruitment in children with early acute lung injury. Pediatr Crit Care Med. 2012 Sep; 13(5):509-15. PMID: 22622650.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  43. Kheir JN, Scharp LA, Borden MA, Swanson EJ, Loxley A, Reese JH, Black KJ, Velazquez LA, Thomson LM, Walsh BK, Mullen KE, Graham DA, Lawlor MW, Brugnara C, Bell DC, McGowan FX. Oxygen gas-filled microparticles provide intravenous oxygen delivery. Sci Transl Med. 2012 Jun 27; 4(140):140ra88. PMID: 22745438.
    Citations: 11     Fields:    Translation:Animals
  44. Wylie MC, Johnson VM, Carpino E, Mullen K, Hauser K, Nedder A, Kheir JN, Rodriguez-Navarro AJ, Zurakowski D, Berde CB. Respiratory, neuromuscular, and cardiovascular effects of neosaxitoxin in isoflurane-anesthetized sheep. Reg Anesth Pain Med. 2012 Mar-Apr; 37(2):152-8. PMID: 22330260.
    Citations: 1     Fields:    Translation:Animals
  45. Swanson EJ, Mohan V, Kheir J, Borden MA. Phospholipid-stabilized microbubble foam for injectable oxygen delivery. Langmuir. 2010 Oct 19; 26(20):15726-9. PMID: 20873807.
    Citations: 15     Fields:    
  46. Kheir JN, Lawlor MW, Ahn ES, Lehmann L, Riviello JJ, Silvera VM, McManus M, Folkerth RD. Neuropathology of a fatal case of posterior reversible encephalopathy syndrome. Pediatr Dev Pathol. 2010 Sep-Oct; 13(5):397-403. PMID: 20158377.
    Citations: 4     Fields:    Translation:Humans
  47. Brilli RJ, Gibson R, Luria JW, Wheeler TA, Shaw J, Linam M, Kheir J, McLain P, Lingsch T, Hall-Haering A, McBride M. Implementation of a medical emergency team in a large pediatric teaching hospital prevents respiratory and cardiopulmonary arrests outside the intensive care unit. Pediatr Crit Care Med. 2007 May; 8(3):236-46; quiz 247. PMID: 17417113.
    Citations: 33     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.