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Ramaswamy Krishnan, Ph.D.

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Columbia University, New York, NYPh.D.05/2004Mechanical Engineering
Columbia University, New York, NYM.Phil05/2003Mechanical Engineering
Columbia University, New York, NYM.S.05/2001Mechanical Engineering
National Institute of Technology, Tiruchirappalli, IndiaB.E.05/1999Mechanical Engineering

I am broadly interested in lung (patho)physiology, cell mechanics, and the relationships between the two. My current focus is asthma exacerbation, a frequently occurring complication in the emergency room.

In driving an asthma exacerbation, my laboratory has elucidated key roles for airway smooth muscle contraction, extracellular matrix stiffening, and a failure of a deep breath to stretch the airway wall. We are currently engaged in translating these discoveries into new asthma medications.

Beyond asthma and the lung, we are also studying numerous diseases in which modulation of cell mechanics is a logical therapeutic target, including vascular and cardiac disease, liver fibrosis, Focal Segmental Glomerulosclerosis (FSGS), and breast cancer.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI151695 (KRISHNAN, RAMASWAMY) Jun 1, 2020 - May 31, 2022
    Screening for inhibitors of allergen-associated airway smooth muscle contraction
    Role: Principal Investigator
  2. R01HL148715 (ZEKI, AMIR A.) May 15, 2020 - Apr 30, 2025
    Reducing Airway Smooth Muscle Tone Using Inhaled Statins
    Role: Co-Investigator
  3. R01HL145392 (PENN, RAYMOND B.) Aug 1, 2019 - Jun 30, 2023
    Cooperative targeting of pharmacomechanical coupling and the actin cytoskeleton to regulate ASM contraction
    Role: Co-Principal Investigator
  4. R01HL139496 (LU, QUAN) Jan 1, 2018 - Nov 30, 2021
    MicroRNA-10a in Airway Smooth Muscle and Asthma
    Role: Co-Investigator
  5. (KRISHNAN, RAMASWAMY) Dec 4, 2017 - Jul 1, 2020
    Evaluation of contractile force screening as a high-throughput approach to measure contractility of activated hepatic stellate cells in vitro
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Panganiban RAM, Yang Z, Sun M, Park CY, Kasahara DI, Schaible N, Krishnan R, Kho AT, Israel E, Hershenson MB, Weiss ST, Himes BE, Fredberg JJ, Tantisira KG, Shore SA, Lu Q. Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness. Nat Commun. 2023 Jan 04; 14(1):47. PMID: 36599824; PMCID: PMC9813361.
    Citations:    Fields:    Translation:Animals
  2. Bai Y, Guedes AGP, Krishnan R, Ai X. CD38 plays an age-related role in cholinergic deregulation of airway smooth muscle contractility. J Allergy Clin Immunol. 2022 05; 149(5):1643-1654.e8. PMID: 34800431; PMCID: PMC9081122.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Husain A, Khadka A, Ehrlicher A, Saint-Geniez M, Krishnan R. Substrate stiffening promotes VEGF-A functions via the PI3K/Akt/mTOR pathway. Biochem Biophys Res Commun. 2022 01 01; 586:27-33. PMID: 34823219; PMCID: PMC8785232.
    Citations: 2     Fields:    Translation:HumansCells
  4. Nayak AP, Lim JM, Arbel E, Wang R, Villalba DR, Nguyen TL, Schaible N, Krishnan R, Tang DD, Penn RB. Cooperativity between ß-agonists and c-Abl inhibitors in regulating airway smooth muscle relaxation. FASEB J. 2021 07; 35(7):e21674. PMID: 34115899; PMCID: PMC8802313.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Deckwirth V, Rajakylä EK, Cattavarayane S, Acheva A, Schaible N, Krishnan R, Valle-Delgado JJ, Österberg M, Björkenheim P, Sukura A, Tojkander S. Cytokeratin 5 determines maturation of the mammary myoepithelium. iScience. 2021 May 21; 24(5):102413. PMID: 34007958.
    Citations: 1     
  6. Acheva A, Kärki T, Schaible N, Krishnan R, Tojkander S. Adipokine Leptin Co-operates With Mechanosensitive Ca2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells. Front Cell Dev Biol. 2020; 8:607038. PMID: 33490070.
    Citations: 3     
  7. Thompson EE, Dang Q, Mitchell-Handley B, Rajendran K, Ram-Mohan S, Solway J, Ober C, Krishnan R. Cytokine-induced molecular responses in airway smooth muscle cells inform genome-wide association studies of asthma. Genome Med. 2020 07 20; 12(1):64. PMID: 32690065.
    Citations: 4     Fields:    Translation:HumansCells
  8. Mondoñedo JR, Bartolák-Suki E, Bou Jawde S, Nelson K, Cao K, Sonnenberg A, Obrochta WP, Imsirovic J, Ram-Mohan S, Krishnan R, Suki B. A High-Throughput System for Cyclic Stretching of Precision-Cut Lung Slices During Acute Cigarette Smoke Extract Exposure. Front Physiol. 2020; 11:566. PMID: 32655401; PMCID: PMC7326018.
  9. Lu RA, Zeki AA, Ram-Mohan S, Nguyen N, Bai Y, Chmiel K, Pecic S, Ai X, Krishnan R, Ghosh CC. Inhibiting Airway Smooth Muscle Contraction Using Pitavastatin: A Role for the Mevalonate Pathway in Regulating Cytoskeletal Proteins. Front Pharmacol. 2020; 11:469. PMID: 32435188; PMCID: PMC7218099.
  10. Li G, Cohen JA, Martines C, Ram-Mohan S, Brain JD, Krishnan R, Ai X, Bai Y. Preserving Airway Smooth Muscle Contraction in Precision-Cut Lung Slices. Sci Rep. 2020 04 15; 10(1):6480. PMID: 32296115.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Stamenovic D, Krishnan R, Canovic EP, Smith ML. As the endothelial cell reorients, its tensile forces stabilize. J Biomech. 2020 05 22; 105:109770. PMID: 32278526.
    Citations: 1     Fields:    Translation:Cells
  12. Rajakylä EK, Lehtimäki JI, Acheva A, Schaible N, Lappalainen P, Krishnan R, Tojkander S. Assembly of Peripheral Actomyosin Bundles in Epithelial Cells Is Dependent on the CaMKK2/AMPK Pathway. Cell Rep. 2020 03 24; 30(12):4266-4280.e4. PMID: 32209483.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  13. Ram-Mohan S, Bai Y, Schaible N, Ehrlicher AJ, Cook DP, Suki B, Stoltz DA, Solway J, Ai X, Krishnan R. Tissue traction microscopy to quantify muscle contraction within precision-cut lung slices. Am J Physiol Lung Cell Mol Physiol. 2020 02 01; 318(2):L323-L330. PMID: 31774304.
    Citations: 2     Fields:    Translation:HumansAnimals
  14. Redes JL, Basu T, Ram-Mohan S, Ghosh CC, Chan EC, Sek AC, Zhao M, Krishnan R, Rosenberg HF, Druey KM. Aspergillus fumigatus-Secreted Alkaline Protease 1 Mediates Airways Hyperresponsiveness in Severe Asthma. Immunohorizons. 2019 08 06; 3(8):368-377. PMID: 31603851.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  15. Polio SR, Stasiak SE, Jamieson RR, Balestrini JL, Krishnan R, Parameswaran H. Extracellular matrix stiffness regulates human airway smooth muscle contraction by altering the cell-cell coupling. Sci Rep. 2019 07 02; 9(1):9564. PMID: 31267003.
    Citations: 15     Fields:    Translation:HumansCells
  16. Yoshie H, Koushki N, Molter C, Siegel PM, Krishnan R, Ehrlicher AJ. High Throughput Traction Force Microscopy Using PDMS Reveals Dose-Dependent Effects of Transforming Growth Factor-ß on the Epithelial-to-Mesenchymal Transition. J Vis Exp. 2019 06 01; (148). PMID: 31205302.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Jiu Y, Kumari R, Fenix AM, Schaible N, Liu X, Varjosalo M, Krishnan R, Burnette DT, Lappalainen P. Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles. Curr Biol. 2019 01 07; 29(1):81-92.e5. PMID: 30581023; PMCID: PMC6347125.
    Citations: 16     Fields:    Translation:HumansCells
  18. Rokhzan R, Ghosh CC, Schaible N, Notbohm J, Yoshie H, Ehrlicher AJ, Higgins SJ, Zhang R, Haller H, Hardin CC, David S, Parikh SM, Krishnan R. Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function. Lab Invest. 2019 01; 99(1):138-145. PMID: 30310180; PMCID: PMC6309267.
    Citations: 2     Fields:    Translation:HumansCells
  19. Chen F, Shao F, Hinds A, Yao S, Ram-Mohan S, Norman TA, Krishnan R, Fine A. Retinoic acid signaling is essential for airway smooth muscle homeostasis. JCI Insight. 2018 08 23; 3(16). PMID: 30135301; PMCID: PMC6141181.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  20. Yoshie H, Koushki N, Kaviani R, Tabatabaei M, Rajendran K, Dang Q, Husain A, Yao S, Li C, Sullivan JK, Saint-Geniez M, Krishnan R, Ehrlicher AJ. Traction Force Screening Enabled by Compliant PDMS Elastomers. Biophys J. 2018 05 08; 114(9):2194-2199. PMID: 29742412.
    Citations: 22     Fields:    Translation:Cells
  21. Feng D, Notbohm J, Benjamin A, He S, Wang M, Ang LH, Bantawa M, Bouzid M, Del Gado E, Krishnan R, Pollak MR. Disease-causing mutation in a-actinin-4 promotes podocyte detachment through maladaptation to periodic stretch. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):1517-1522. PMID: 29378953; PMCID: PMC5816190.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  22. Lan B, Krishnan R, Park CY, Watanabe RA, Panganiban R, Butler JP, Lu Q, Cole WC, Fredberg JJ. Transient stretch induces cytoskeletal fluidization through the severing action of cofilin. Am J Physiol Lung Cell Mol Physiol. 2018 05 01; 314(5):L799-L807. PMID: 29345194; PMCID: PMC6008132.
    Citations: 10     Fields:    Translation:HumansCells
  23. Hardin CC, Chattoraj J, Manomohan G, Colombo J, Nguyen T, Tambe D, Fredberg JJ, Birukov K, Butler JP, Del Gado E, Krishnan R. Long-range stress transmission guides endothelial gap formation. Biochem Biophys Res Commun. 2018 01 01; 495(1):749-754. PMID: 29137986; PMCID: PMC5761675.
    Citations: 9     Fields:    Translation:HumansCells
  24. Bartolák-Suki E, Imsirovic J, Nishibori Y, Krishnan R, Suki B. Regulation of Mitochondrial Structure and Dynamics by the Cytoskeleton and Mechanical Factors. Int J Mol Sci. 2017 Aug 21; 18(8). PMID: 28825689; PMCID: PMC5578198.
    Citations: 47     Fields:    Translation:HumansCells
  25. Suki B, Hu Y, Murata N, Imsirovic J, Mondoñedo JR, de Oliveira CLN, Schaible N, Allen PG, Krishnan R, Bartolák-Suki E. A microfluidic chamber-based approach to map the shear moduli of vascular cells and other soft materials. Sci Rep. 2017 05 23; 7(1):2305. PMID: 28536424.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  26. Rosner SR, Pascoe CD, Blankman E, Jensen CC, Krishnan R, James AL, Elliot JG, Green FH, Liu JC, Seow CY, Park JA, Beckerle MC, Paré PD, Fredberg JJ, Smith MA. The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics. PLoS One. 2017; 12(3):e0171728. PMID: 28278518.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  27. Hiorns JE, Bidan CM, Jensen OE, Gosens R, Kistemaker LE, Fredberg JJ, Butler JP, Krishnan R, Brook BS. Corrigendum: Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice. Front Physiol. 2017; 8:117. PMID: 28261114; PMCID: PMC5329043.
  28. Jiu Y, Peränen J, Schaible N, Cheng F, Eriksson JE, Krishnan R, Lappalainen P. Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA. J Cell Sci. 2017 03 01; 130(5):892-902. PMID: 28096473; PMCID: PMC5358333.
    Citations: 59     Fields:    Translation:HumansCells
  29. Feng D, Steinke JM, Krishnan R, Birrane G, Pollak MR. Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing. PLoS One. 2016; 11(12):e0167467. PMID: 27977723.
    Citations: 7     Fields:    Translation:Humans
  30. Hiorns JE, Bidan CM, Jensen OE, Gosens R, Kistemaker LE, Fredberg JJ, Butler JP, Krishnan R, Brook BS. Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice. Front Physiol. 2016; 7:309. PMID: 27559314.
    Citations: 12     
  31. Nadkarni NA, Rajakumar A, Mokhashi N, Burke SD, Rana S, Salahuddin S, Dang Q, Thadhani R, Krishnan R, Stossel TP, Karumanchi SA. Gelsolin is an endogenous inhibitor of syncytiotrophoblast extracellular vesicle shedding in pregnancy. Pregnancy Hypertens. 2016 Oct; 6(4):333-339. PMID: 27939478.
    Citations: 3     Fields:    Translation:HumansCells
  32. Cook DP, Rector MV, Bouzek DC, Michalski AS, Gansemer ND, Reznikov LR, Li X, Stroik MR, Ostedgaard LS, Abou Alaiwa MH, Thompson MA, Prakash YS, Krishnan R, Meyerholz DK, Seow CY, Stoltz DA. Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility. Am J Respir Crit Care Med. 2016 Feb 15; 193(4):417-26. PMID: 26488271; PMCID: PMC4803085.
    Citations: 31     Fields:    Translation:AnimalsCells
  33. Watson CY, Damiani F, Ram-Mohan S, Rodrigues S, de Moura Queiroz P, Donaghey TC, Rosenblum Lichtenstein JH, Brain JD, Krishnan R, Molina RM. Screening for Chemical Toxicity Using Cryopreserved Precision Cut Lung Slices. Toxicol Sci. 2016 Mar; 150(1):225-33. PMID: 26719368; PMCID: PMC5009619.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  34. Tojkander S, Gateva G, Husain A, Krishnan R, Lappalainen P. Generation of contractile actomyosin bundles depends on mechanosensitive actin filament assembly and disassembly. Elife. 2015 Dec 10; 4:e06126. PMID: 26652273.
    Citations: 60     Fields:    Translation:HumansCells
  35. Krishnan R, Park JA, Seow CY, Lee PV, Stewart AG. Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology. Trends Pharmacol Sci. 2016 Feb; 37(2):87-100. PMID: 26651416; PMCID: PMC4922134.
    Citations: 14     Fields:    Translation:Humans
  36. Morley S, You S, Pollan S, Choi J, Zhou B, Hager MH, Steadman K, Spinelli C, Rajendran K, Gertych A, Kim J, Adam RM, Yang W, Krishnan R, Knudsen BS, Di Vizio D, Freeman MR. Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes. Sci Rep. 2015 Jul 16; 5:12136. PMID: 26179371.
    Citations: 22     Fields:    Translation:HumansCells
  37. Park CY, Zhou EH, Tambe D, Chen B, Lavoie T, Dowell M, Simeonov A, Maloney DJ, Marinkovic A, Tschumperlin DJ, Burger S, Frykenberg M, Butler JP, Stamer WD, Johnson M, Solway J, Fredberg JJ, Krishnan R. High-throughput screening for modulators of cellular contractile force. Integr Biol (Camb). 2015 Oct; 7(10):1318-24. PMID: 25953078.
    Citations: 30     Fields:    Translation:HumansCells
  38. Ehrlicher AJ, Krishnan R, Guo M, Bidan CM, Weitz DA, Pollak MR. Alpha-actinin binding kinetics modulate cellular dynamics and force generation. Proc Natl Acad Sci U S A. 2015 May 26; 112(21):6619-24. PMID: 25918384; PMCID: PMC4450414.
    Citations: 43     Fields:    Translation:HumansCells
  39. Beckers CM, Knezevic N, Valent ET, Tauseef M, Krishnan R, Rajendran K, Hardin CC, Aman J, van Bezu J, Sweetnam P, van Hinsbergh VW, Mehta D, van Nieuw Amerongen GP. ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension. Vascul Pharmacol. 2015 Jul; 70:45-54. PMID: 25869521; PMCID: PMC4606924.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  40. Steward R, Tambe D, Hardin CC, Krishnan R, Fredberg JJ. Fluid shear, intercellular stress, and endothelial cell alignment. Am J Physiol Cell Physiol. 2015 Apr 15; 308(8):C657-64. PMID: 25652451; PMCID: PMC4398851.
    Citations: 32     Fields:    Translation:HumansCells
  41. Brill-Karniely Y, Nisenholz N, Rajendran K, Dang Q, Krishnan R, Zemel A. Dynamics of cell area and force during spreading. Biophys J. 2014 Dec 16; 107(12):L37-L40. PMID: 25517168; PMCID: PMC4269772.
    Citations: 3     Fields:    Translation:HumansCells
  42. Nisenholz N, Rajendran K, Dang Q, Chen H, Kemkemer R, Krishnan R, Zemel A. Active mechanics and dynamics of cell spreading on elastic substrates. Soft Matter. 2014 Oct 07; 10(37):7234-46. PMID: 25103537.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  43. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81. PMID: 24313705.
    Citations: 22     Fields:    Translation:AnimalsCells
  44. Dowell ML, Lavoie TL, Solway J, Krishnan R. Airway smooth muscle: a potential target for asthma therapy. Curr Opin Pulm Med. 2014 Jan; 20(1):66-72. PMID: 24247041.
    Citations: 9     Fields:    Translation:HumansCells
  45. Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907. PMID: 24221086.
    Citations: 31     Fields:    Translation:Animals
  46. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469. PMID: 24040256.
    Citations: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  47. Kim JH, Serra-Picamal X, Tambe DT, Zhou EH, Park CY, Sadati M, Park JA, Krishnan R, Gweon B, Millet E, Butler JP, Trepat X, Fredberg JJ. Propulsion and navigation within the advancing monolayer sheet. Nat Mater. 2013 Sep; 12(9):856-63. PMID: 23793160; PMCID: PMC3750079.
    Citations: 84     Fields:    Translation:AnimalsCells
  48. Sadati M, Taheri Qazvini N, Krishnan R, Park CY, Fredberg JJ. Collective migration and cell jamming. Differentiation. 2013 Oct; 86(3):121-5. PMID: 23791490.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  49. Hardin C, Rajendran K, Manomohan G, Tambe DT, Butler JP, Fredberg JJ, Martinelli R, Carman CV, Krishnan R. Glassy dynamics, cell mechanics, and endothelial permeability. J Phys Chem B. 2013 Oct 24; 117(42):12850-6. PMID: 23638866.
    Citations: 11     Fields:    Translation:HumansCells
  50. Kach J, Sandbo N, Sethakorn N, Williams J, Reed EB, La J, Tian X, Brain SD, Rajendran K, Krishnan R, Sperling AI, Birukov K, Dulin NO. Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 01; 304(11):L757-64. PMID: 23585227.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  51. Hardin C, Fredberg JJ, Krishnan R. Real estate of monolayer permeability: location location location. Lab Invest. 2013 Feb; 93(2):148-50. PMID: 23361599.
    Citations: 1     Fields:    Translation:HumansCells
  52. Ramachandran A, Gangopadhyay SS, Krishnan R, Ranpura SA, Rajendran K, Ram-Mohan S, Mulone M, Gong EM, Adam RM. JunB mediates basal- and TGFß1-induced smooth muscle cell contractility. PLoS One. 2013; 8(1):e53430. PMID: 23308222.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  53. Patel NR, Bole M, Chen C, Hardin CC, Kho AT, Mih J, Deng L, Butler J, Tschumperlin D, Fredberg JJ, Krishnan R, Koziel H. Cell elasticity determines macrophage function. PLoS One. 2012; 7(9):e41024. PMID: 23028423.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  54. Krishnan R, Canovic EP, Iordan AL, Rajendran K, Manomohan G, Pirentis AP, Smith ML, Butler JP, Fredberg JJ, Stamenovic D. Fluidization, resolidification, and reorientation of the endothelial cell in response to slow tidal stretches. Am J Physiol Cell Physiol. 2012 Aug 15; 303(4):C368-75. PMID: 22700796.
    Citations: 28     Fields:    Translation:HumansCells
  55. Bielenberg DR, Seth A, Shimizu A, Pelton K, Cristofaro V, Ramachandran A, Zwaans BM, Chen C, Krishnan R, Seth M, Huang L, Takashima S, Klagsbrun M, Sullivan MP, Adam RM. Increased smooth muscle contractility in mice deficient for neuropilin 2. Am J Pathol. 2012 Aug; 181(2):548-59. PMID: 22688055; PMCID: PMC3409431.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  56. Lavoie TL, Krishnan R, Siegel HR, Maston ED, Fredberg JJ, Solway J, Dowell ML. Dilatation of the constricted human airway by tidal expansion of lung parenchyma. Am J Respir Crit Care Med. 2012 Aug 01; 186(3):225-32. PMID: 22679010; PMCID: PMC3423451.
    Citations: 43     Fields:    Translation:Humans
  57. Mizrahi N, Zhou EH, Lenormand G, Krishnan R, Weihs D, Butler JP, Weitz DA, Fredberg JJ, Kimmel E. Low intensity ultrasound perturbs cytoskeleton dynamics. Soft Matter. 2012 Feb 28; 8(8):2438-2443. PMID: 23646063.
    Citations: 30     Fields:    
  58. Jiang X, Pan H, Nabhan JF, Krishnan R, Koziol-White C, Panettieri RA, Lu Q. A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in ß2-adrenergic receptor internalization and down-regulation. FASEB J. 2012 May; 26(5):1995-2007. PMID: 22278941.
    Citations: 7     Fields:    Translation:HumansCells
  59. Krishnan R, Fredberg JJ. In bronchospasm, fluctuations come to life. Am J Respir Crit Care Med. 2011 Dec 15; 184(12):1321-2. PMID: 22174106.
    Citations:    Fields:    Translation:Humans
  60. Prager-Khoutorsky M, Lichtenstein A, Krishnan R, Rajendran K, Mayo A, Kam Z, Geiger B, Bershadsky AD. Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing. Nat Cell Biol. 2011 Nov 13; 13(12):1457-65. PMID: 22081092.
    Citations: 200     Fields:    Translation:HumansCells
  61. Lin YC, Tambe DT, Park CY, Wasserman MR, Trepat X, Krishnan R, Lenormand G, Fredberg JJ, Butler JP. Mechanosensing of substrate thickness. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Oct; 82(4 Pt 1):041918. PMID: 21230324.
    Citations: 25     Fields:    Translation:HumansCells
  62. Krishnan R, Klumpers DD, Park CY, Rajendran K, Trepat X, van Bezu J, van Hinsbergh VW, Carman CV, Brain JD, Fredberg JJ, Butler JP, van Nieuw Amerongen GP. Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C146-54. PMID: 20861463.
    Citations: 99     Fields:    Translation:HumansCells
  63. Chen C, Krishnan R, Zhou E, Ramachandran A, Tambe D, Rajendran K, Adam RM, Deng L, Fredberg JJ. Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch. PLoS One. 2010 Aug 06; 5(8):e12035. PMID: 20700509.
    Citations: 40     Fields:    Translation:HumansCells
  64. Krishnan R, Park CY, Lin YC, Mead J, Jaspers RT, Trepat X, Lenormand G, Tambe D, Smolensky AV, Knoll AH, Butler JP, Fredberg JJ. Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness. PLoS One. 2009; 4(5):e5486. PMID: 19424501.
    Citations: 123     Fields:    Translation:HumansCells
  65. Krishnan R, Trepat X, Nguyen TT, Lenormand G, Oliver M, Fredberg JJ. Airway smooth muscle and bronchospasm: fluctuating, fluidizing, freezing. Respir Physiol Neurobiol. 2008 Nov 30; 163(1-3):17-24. PMID: 18514592.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.