Ramaswamy Krishnan, Ph.D.
Title Associate Professor of Emergency Medicine Institution Beth Israel Deaconess Medical Center Department Emergency Medicine Address Beth Israel Deaconess Medical Center
Emergency Medicine
330 Brookline Ave
Boston MA 02215
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Biography
| Columbia University, New York, NY | Ph.D. | 05/2004 | Mechanical Engineering |
| Columbia University, New York, NY | M.Phil | 05/2003 | Mechanical Engineering |
| Columbia University, New York, NY | M.S. | 05/2001 | Mechanical Engineering |
| National Institute of Technology, Tiruchirappalli, India | B.E. | 05/1999 | Mechanical Engineering |
Overview
I am broadly interested in lung (patho)physiology, cell mechanics, and the relationships between the two. My current focus is asthma exacerbation, a frequently occurring complication in the emergency room.
In driving an asthma exacerbation, my laboratory has elucidated key roles for airway smooth muscle contraction, extracellular matrix stiffening, and a failure of a deep breath to stretch the airway wall. We are currently engaged in translating these discoveries into new asthma medications.
Beyond asthma and the lung, we are also studying numerous diseases in which modulation of cell mechanics is a logical therapeutic target, including vascular and cardiac disease, liver fibrosis, Focal Segmental Glomerulosclerosis (FSGS), and breast cancer.
Research
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
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R21DK138394
(ADAM, ROSALYN M)
Sep 20, 2023 - Aug 31, 2025
Precision-cut bladder slices: an enabling technology for urologic research
Role: Co-Principal Investigator
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R21AI151695
(KRISHNAN, RAMASWAMY)
Jun 1, 2020 - May 31, 2022
Screening for inhibitors of allergen-associated airway smooth muscle contraction
Role: Principal Investigator
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R01HL148715
(ZEKI, AMIR A.)
May 15, 2020 - Apr 30, 2025
Reducing Airway Smooth Muscle Tone Using Inhaled Statins
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R01HL145392
(KRISHNAN, RAMASWAMY ;PENN, RAYMOND B. ;TANG, DALE D.)
Aug 1, 2019 - Jun 30, 2024
Cooperative targeting of pharmacomechanical coupling and the actin cytoskeleton to regulate ASM contraction
Role: Co-Principal Investigator
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R01HL139496
(LU, QUAN)
Jan 1, 2018 - Nov 30, 2021
MicroRNA-10a in Airway Smooth Muscle and Asthma
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(KRISHNAN, RAMASWAMY)
Dec 4, 2017 - Jul 1, 2020
Evaluation of contractile force screening as a high-throughput approach to measure contractility of activated hepatic stellate cells in vitro
Role: Principal Investigator
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R01HL136209
(PENN, RAYMOND B.)
Feb 1, 2017 - Jan 31, 2021
Optimizing EP receptor subtype targeting for asthma therapy
Role: Co-Principal Investigator
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1R56HL133205-01
(HARDIN, CHARLES COREY)
Sep 2, 2016 - Aug 31, 2017
Cell Mechanical Endotypes in the Acute Respiratory Distress Syndrome
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R21HL123522
(KRISHNAN, RAMASWAMY)
Aug 1, 2016 - Jul 31, 2019
Monitoring contractile forces during airway constriction
Role: Principal Investigator
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NIH 4 R37 DK059588-17
(POLLAK, MARTIN)
Jul 21, 2016 - Jun 30, 2021
Biological Mechanism of FSGS-1
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R01HL130287
(CHEN, FELICIA)
Apr 20, 2016 - Mar 31, 2020
Regulation of airway smooth muscle phenotype by retinoic acid
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(BRAIN, JOSEPH)
May 10, 2015 - Apr 30, 2016
Pilot grant from the National Institute of Environmental Health Sciences center at the Harvard School of Public Health
Assessment of environmental toxins: Bridging the gap between cell assays and intact animals
Role: Co-Principal Investigator
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(DULIN, NICKOLAI)
May 1, 2015 - Apr 30, 2016
Falk Medical Research Trust
Development of a novel small molecule for treatment of fibrotic diseases
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UH2HL123816
(SOLWAY, JULIAN)
Sep 22, 2014 - Jun 30, 2019
Preclinical development of myosolvins, a new class of medicine for asthma
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P01HL120839
(FREDBERG, JEFFREY J)
Aug 1, 2014 - Dec 31, 2019
Physics of collective cellular migration in lung health and disease
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R01HL113395
(THOMPSON, EMMA E)
Mar 1, 2014 - Feb 28, 2019
Dissecting the Genetic Architecture of Airway Hyperresponsiveness
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(KRISHNAN, RAMASWAMY)
May 1, 2013 - Apr 30, 2016
Evaluating smooth muscle relaxation using monolayer traction microscopy
Role: Principal Investigator
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(KRISHNAN, RAMASWAMY)
May 1, 2010 - Apr 30, 2013
Parker Francis Foundation
Physical forces and regulation of pulmonary endothelial integrity
Bibliographic
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