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Ramaswamy Krishnan, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL136209 (PENN, RAYMOND B.) Feb 1, 2017 - Jan 31, 2021
    NIH/NHLBI
    Optimizing EP receptor subtype targeting for asthma therapy
    Role: Co-Principal Investigator
  2. R21HL123522 (KRISHNAN, RAMASWAMY) Aug 1, 2016 - Jul 31, 2018
    NIH/NHLBI
    Monitoring contractile forces during airway constriction
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jiu Y, Kumari R, Fenix AM, Schaible N, Liu X, Varjosalo M, Krishnan R, Burnette DT, Lappalainen P. Myosin-18B Promotes the Assembly of Myosin II Stacks for Maturation of Contractile Actomyosin Bundles. Curr Biol. 2019 Jan 07; 29(1):81-92.e5. PMID: 30581023.
    Citations:    Fields:    
  2. Rokhzan R, Ghosh CC, Schaible N, Notbohm J, Yoshie H, Ehrlicher AJ, Higgins SJ, Zhang R, Haller H, Hardin CC, David S, Parikh SM, Krishnan R. Multiplexed, high-throughput measurements of cell contraction and endothelial barrier function. Lab Invest. 2019 Jan; 99(1):138-145. PMID: 30310180.
    Citations:    Fields:    
  3. Chen F, Shao F, Hinds A, Yao S, Ram-Mohan S, Norman TA, Krishnan R, Fine A. Retinoic acid signaling is essential for airway smooth muscle homeostasis. JCI Insight. 2018 Aug 23; 3(16). PMID: 30135301.
    Citations:    Fields:    
  4. Yoshie H, Koushki N, Kaviani R, Tabatabaei M, Rajendran K, Dang Q, Husain A, Yao S, Li C, Sullivan JK, Saint-Geniez M, Krishnan R, Ehrlicher AJ. Traction Force Screening Enabled by Compliant PDMS Elastomers. Biophys J. 2018 May 08; 114(9):2194-2199. PMID: 29742412.
    Citations:    Fields:    
  5. Feng D, Notbohm J, Benjamin A, He S, Wang M, Ang LH, Bantawa M, Bouzid M, Del Gado E, Krishnan R, Pollak MR. Disease-causing mutation in a-actinin-4 promotes podocyte detachment through maladaptation to periodic stretch. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):1517-1522. PMID: 29378953.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Lan B, Krishnan R, Park CY, Watanabe RA, Panganiban R, Butler JP, Lu Q, Cole WC, Fredberg JJ. Transient stretch induces cytoskeletal fluidization through the severing action of cofilin. Am J Physiol Lung Cell Mol Physiol. 2018 05 01; 314(5):L799-L807. PMID: 29345194.
    Citations:    Fields:    Translation:HumansCells
  7. Hardin CC, Chattoraj J, Manomohan G, Colombo J, Nguyen T, Tambe D, Fredberg JJ, Birukov K, Butler JP, Del Gado E, Krishnan R. Long-range stress transmission guides endothelial gap formation. Biochem Biophys Res Commun. 2018 01 01; 495(1):749-754. PMID: 29137986.
    Citations:    Fields:    Translation:HumansCells
  8. Suki B, Hu Y, Murata N, Imsirovic J, Mondoñedo JR, de Oliveira CLN, Schaible N, Allen PG, Krishnan R, Bartolák-Suki E. A microfluidic chamber-based approach to map the shear moduli of vascular cells and other soft materials. Sci Rep. 2017 05 23; 7(1):2305. PMID: 28536424.
    Citations:    Fields:    Translation:HumansAnimalsCells
  9. Rosner SR, Pascoe CD, Blankman E, Jensen CC, Krishnan R, James AL, Elliot JG, Green FH, Liu JC, Seow CY, Park JA, Beckerle MC, Paré PD, Fredberg JJ, Smith MA. The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics. PLoS One. 2017; 12(3):e0171728. PMID: 28278518.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Hiorns JE, Bidan CM, Jensen OE, Gosens R, Kistemaker LE, Fredberg JJ, Butler JP, Krishnan R, Brook BS. Corrigendum: Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice. Front Physiol. 2017; 8:117. PMID: 28261114.
    Citations:    
  11. Jiu Y, Peränen J, Schaible N, Cheng F, Eriksson JE, Krishnan R, Lappalainen P. Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA. J Cell Sci. 2017 03 01; 130(5):892-902. PMID: 28096473.
    Citations: 11     Fields:    Translation:HumansCells
  12. Feng D, Steinke JM, Krishnan R, Birrane G, Pollak MR. Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing. PLoS One. 2016; 11(12):e0167467. PMID: 27977723.
    Citations: 1     Fields:    Translation:Humans
  13. Hiorns JE, Bidan CM, Jensen OE, Gosens R, Kistemaker LE, Fredberg JJ, Butler JP, Krishnan R, Brook BS. Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice. Front Physiol. 2016; 7:309. PMID: 27559314; PMCID: PMC4989902.
    Citations: 3     
  14. Nadkarni NA, Rajakumar A, Mokhashi N, Burke SD, Rana S, Salahuddin S, Dang Q, Thadhani R, Krishnan R, Stossel TP, Karumanchi SA. Gelsolin is an endogenous inhibitor of syncytiotrophoblast extracellular vesicle shedding in pregnancy. Pregnancy Hypertens. 2016 Oct; 6(4):333-339. PMID: 27939478.
    Citations: 1     Fields:    Translation:HumansCells
  15. Cook DP, Rector MV, Bouzek DC, Michalski AS, Gansemer ND, Reznikov LR, Li X, Stroik MR, Ostedgaard LS, Abou Alaiwa MH, Thompson MA, Prakash YS, Krishnan R, Meyerholz DK, Seow CY, Stoltz DA. Cystic Fibrosis Transmembrane Conductance Regulator in Sarcoplasmic Reticulum of Airway Smooth Muscle. Implications for Airway Contractility. Am J Respir Crit Care Med. 2016 Feb 15; 193(4):417-26. PMID: 26488271.
    Citations: 12     Fields:    Translation:AnimalsCells
  16. Watson CY, Damiani F, Ram-Mohan S, Rodrigues S, de Moura Queiroz P, Donaghey TC, Rosenblum Lichtenstein JH, Brain JD, Krishnan R, Molina RM. Screening for Chemical Toxicity Using Cryopreserved Precision Cut Lung Slices. Toxicol Sci. 2016 Mar; 150(1):225-33. PMID: 26719368.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  17. Krishnan R, Park JA, Seow CY, Lee PV, Stewart AG. Cellular Biomechanics in Drug Screening and Evaluation: Mechanopharmacology. Trends Pharmacol Sci. 2016 Feb; 37(2):87-100. PMID: 26651416.
    Citations: 3     Fields:    Translation:Humans
  18. Morley S, You S, Pollan S, Choi J, Zhou B, Hager MH, Steadman K, Spinelli C, Rajendran K, Gertych A, Kim J, Adam RM, Yang W, Krishnan R, Knudsen BS, Di Vizio D, Freeman MR. Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes. Sci Rep. 2015 Jul 16; 5:12136. PMID: 26179371; PMCID: PMC4503992.
    Citations: 5     Fields:    Translation:HumansCells
  19. Park CY, Zhou EH, Tambe D, Chen B, Lavoie T, Dowell M, Simeonov A, Maloney DJ, Marinkovic A, Tschumperlin DJ, Burger S, Frykenberg M, Butler JP, Stamer WD, Johnson M, Solway J, Fredberg JJ, Krishnan R. High-throughput screening for modulators of cellular contractile force. Integr Biol (Camb). 2015 Oct; 7(10):1318-24. PMID: 25953078; PMCID: PMC4657543.
    Citations: 9     Fields:    Translation:HumansCells
  20. Ehrlicher AJ, Krishnan R, Guo M, Bidan CM, Weitz DA, Pollak MR. Alpha-actinin binding kinetics modulate cellular dynamics and force generation. Proc Natl Acad Sci U S A. 2015 May 26; 112(21):6619-24. PMID: 25918384; PMCID: PMC4450414.
    Citations: 21     Fields:    Translation:HumansCells
  21. Beckers CM, Knezevic N, Valent ET, Tauseef M, Krishnan R, Rajendran K, Hardin CC, Aman J, van Bezu J, Sweetnam P, van Hinsbergh VW, Mehta D, van Nieuw Amerongen GP. ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension. Vascul Pharmacol. 2015 Jul; 70:45-54. PMID: 25869521; PMCID: PMC4606924.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  22. Steward R, Tambe D, Hardin CC, Krishnan R, Fredberg JJ. Fluid shear, intercellular stress, and endothelial cell alignment. Am J Physiol Cell Physiol. 2015 Apr 15; 308(8):C657-64. PMID: 25652451; PMCID: PMC4398851.
    Citations: 12     Fields:    Translation:HumansCells
  23. Brill-Karniely Y, Nisenholz N, Rajendran K, Dang Q, Krishnan R, Zemel A. Dynamics of cell area and force during spreading. Biophys J. 2014 Dec 16; 107(12):L37-L40. PMID: 25517168.
    Citations:    Fields:    Translation:HumansCells
  24. Nisenholz N, Rajendran K, Dang Q, Chen H, Kemkemer R, Krishnan R, Zemel A. Active mechanics and dynamics of cell spreading on elastic substrates. Soft Matter. 2014 Oct 07; 10(37):7234-46. PMID: 25103537.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  25. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81. PMID: 24313705; PMCID: PMC4068941.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Dowell ML, Lavoie TL, Solway J, Krishnan R. Airway smooth muscle: a potential target for asthma therapy. Curr Opin Pulm Med. 2014 Jan; 20(1):66-72. PMID: 24247041.
    Citations: 5     Fields:    Translation:HumansCells
  27. Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907. PMID: 24221086; PMCID: PMC3898648.
    Citations: 13     Fields:    Translation:Animals
  28. Paez-Cortez J, Krishnan R, Arno A, Aven L, Ram-Mohan S, Patel KR, Lu J, King OD, Ai X, Fine A. A new approach for the study of lung smooth muscle phenotypes and its application in a murine model of allergic airway inflammation. PLoS One. 2013; 8(9):e74469. PMID: 24040256; PMCID: PMC3767675.
    Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  29. Kim JH, Serra-Picamal X, Tambe DT, Zhou EH, Park CY, Sadati M, Park JA, Krishnan R, Gweon B, Millet E, Butler JP, Trepat X, Fredberg JJ. Propulsion and navigation within the advancing monolayer sheet. Nat Mater. 2013 Sep; 12(9):856-63. PMID: 23793160; PMCID: PMC3750079.
    Citations: 38     Fields:    Translation:AnimalsCells
  30. Sadati M, Taheri Qazvini N, Krishnan R, Park CY, Fredberg JJ. Collective migration and cell jamming. Differentiation. 2013 Oct; 86(3):121-5. PMID: 23791490; PMCID: PMC3795803.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  31. Hardin C, Rajendran K, Manomohan G, Tambe DT, Butler JP, Fredberg JJ, Martinelli R, Carman CV, Krishnan R. Glassy dynamics, cell mechanics, and endothelial permeability. J Phys Chem B. 2013 Oct 24; 117(42):12850-6. PMID: 23638866; PMCID: PMC3808527.
    Citations: 1     Fields:    Translation:HumansCells
  32. Kach J, Sandbo N, Sethakorn N, Williams J, Reed EB, La J, Tian X, Brain SD, Rajendran K, Krishnan R, Sperling AI, Birukov K, Dulin NO. Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 01; 304(11):L757-64. PMID: 23585227.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  33. Hardin C, Fredberg JJ, Krishnan R. Real estate of monolayer permeability: location location location. Lab Invest. 2013 Feb; 93(2):148-50. PMID: 23361599.
    Citations: 1     Fields:    Translation:HumansCells
  34. Ramachandran A, Gangopadhyay SS, Krishnan R, Ranpura SA, Rajendran K, Ram-Mohan S, Mulone M, Gong EM, Adam RM. JunB mediates basal- and TGFß1-induced smooth muscle cell contractility. PLoS One. 2013; 8(1):e53430. PMID: 23308222; PMCID: PMC3537614.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  35. Patel NR, Bole M, Chen C, Hardin CC, Kho AT, Mih J, Deng L, Butler J, Tschumperlin D, Fredberg JJ, Krishnan R, Koziel H. Cell elasticity determines macrophage function. PLoS One. 2012; 7(9):e41024. PMID: 23028423; PMCID: PMC3445606.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  36. Krishnan R, Canovic EP, Iordan AL, Rajendran K, Manomohan G, Pirentis AP, Smith ML, Butler JP, Fredberg JJ, Stamenovic D. Fluidization, resolidification, and reorientation of the endothelial cell in response to slow tidal stretches. Am J Physiol Cell Physiol. 2012 Aug 15; 303(4):C368-75. PMID: 22700796.
    Citations: 13     Fields:    Translation:HumansCells
  37. Bielenberg DR, Seth A, Shimizu A, Pelton K, Cristofaro V, Ramachandran A, Zwaans BM, Chen C, Krishnan R, Seth M, Huang L, Takashima S, Klagsbrun M, Sullivan MP, Adam RM. Increased smooth muscle contractility in mice deficient for neuropilin 2. Am J Pathol. 2012 Aug; 181(2):548-59. PMID: 22688055; PMCID: PMC3409431.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  38. Lavoie TL, Krishnan R, Siegel HR, Maston ED, Fredberg JJ, Solway J, Dowell ML. Dilatation of the constricted human airway by tidal expansion of lung parenchyma. Am J Respir Crit Care Med. 2012 Aug 01; 186(3):225-32. PMID: 22679010; PMCID: PMC3423451.
    Citations: 26     Fields:    Translation:Humans
  39. Mizrahi N, Zhou EH, Lenormand G, Krishnan R, Weihs D, Butler JP, Weitz DA, Fredberg JJ, Kimmel E. Low intensity ultrasound perturbs cytoskeleton dynamics. Soft Matter. 2012 Feb 28; 8(8):2438-2443. PMID: 23646063.
    Citations: 6     Fields:    
  40. Jiang X, Pan H, Nabhan JF, Krishnan R, Koziol-White C, Panettieri RA, Lu Q. A novel EST-derived RNAi screen reveals a critical role for farnesyl diphosphate synthase in ß2-adrenergic receptor internalization and down-regulation. FASEB J. 2012 May; 26(5):1995-2007. PMID: 22278941; PMCID: PMC3336790.
    Citations: 5     Fields:    Translation:HumansCells
  41. Krishnan R, Fredberg JJ. In bronchospasm, fluctuations come to life. Am J Respir Crit Care Med. 2011 Dec 15; 184(12):1321-2. PMID: 22174106.
    Citations:    Fields:    Translation:Humans
  42. Prager-Khoutorsky M, Lichtenstein A, Krishnan R, Rajendran K, Mayo A, Kam Z, Geiger B, Bershadsky AD. Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing. Nat Cell Biol. 2011 Nov 13; 13(12):1457-65. PMID: 22081092.
    Citations: 116     Fields:    Translation:HumansCells
  43. Lin YC, Tambe DT, Park CY, Wasserman MR, Trepat X, Krishnan R, Lenormand G, Fredberg JJ, Butler JP. Mechanosensing of substrate thickness. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Oct; 82(4 Pt 1):041918. PMID: 21230324; PMCID: PMC3641827.
    Citations: 17     Fields:    Translation:HumansCells
  44. Krishnan R, Klumpers DD, Park CY, Rajendran K, Trepat X, van Bezu J, van Hinsbergh VW, Carman CV, Brain JD, Fredberg JJ, Butler JP, van Nieuw Amerongen GP. Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C146-54. PMID: 20861463.
    Citations: 61     Fields:    Translation:HumansCells
  45. Chen C, Krishnan R, Zhou E, Ramachandran A, Tambe D, Rajendran K, Adam RM, Deng L, Fredberg JJ. Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch. PLoS One. 2010 Aug 06; 5(8):e12035. PMID: 20700509; PMCID: PMC2917357.
    Citations: 30     Fields:    Translation:HumansCells
  46. Krishnan R, Park CY, Lin YC, Mead J, Jaspers RT, Trepat X, Lenormand G, Tambe D, Smolensky AV, Knoll AH, Butler JP, Fredberg JJ. Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness. PLoS One. 2009; 4(5):e5486. PMID: 19424501; PMCID: PMC2675060.
    Citations: 81     Fields:    Translation:HumansCells
  47. Krishnan R, Trepat X, Nguyen TT, Lenormand G, Oliver M, Fredberg JJ. Airway smooth muscle and bronchospasm: fluctuating, fluidizing, freezing. Respir Physiol Neurobiol. 2008 Nov 30; 163(1-3):17-24. PMID: 18514592; PMCID: PMC2591927.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.