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Ramaswamy Krishnan, Ph.D.

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Biography
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Columbia University, New York, NYPh.D.05/2004Mechanical Engineering
Columbia University, New York, NYM.Phil05/2003Mechanical Engineering
Columbia University, New York, NYM.S.05/2001Mechanical Engineering
National Institute of Technology, Tiruchirappalli, IndiaB.E.05/1999Mechanical Engineering

Overview
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I am broadly interested in lung (patho)physiology, cell mechanics, and the relationships between the two. My current focus is asthma exacerbation, a frequently occurring complication in the emergency room.

In driving an asthma exacerbation, my laboratory has elucidated key roles for airway smooth muscle contraction, extracellular matrix stiffening, and a failure of a deep breath to stretch the airway wall. We are currently engaged in translating these discoveries into new asthma medications.

Beyond asthma and the lung, we are also studying numerous diseases in which modulation of cell mechanics is a logical therapeutic target, including vascular and cardiac disease, liver fibrosis, Focal Segmental Glomerulosclerosis (FSGS), and breast cancer.
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21DK138394 (ADAM, ROSALYN M) Sep 20, 2023 - Aug 31, 2025
    NIH
    Precision-cut bladder slices: an enabling technology for urologic research
    Role: Co-Principal Investigator
  2. R21AI151695 (KRISHNAN, RAMASWAMY) Jun 1, 2020 - May 31, 2022
    NIH
    Screening for inhibitors of allergen-associated airway smooth muscle contraction
    Role: Principal Investigator
  3. R01HL148715 (ZEKI, AMIR A.) May 15, 2020 - Apr 30, 2025
    NIH
    Reducing Airway Smooth Muscle Tone Using Inhaled Statins
    Role: Co-Investigator
  4. R01HL145392 (KRISHNAN, RAMASWAMY ;PENN, RAYMOND B. ;TANG, DALE D.) Aug 1, 2019 - Jun 30, 2024
    NIH
    Cooperative targeting of pharmacomechanical coupling and the actin cytoskeleton to regulate ASM contraction
    Role: Co-Principal Investigator
  5. R01HL139496 (LU, QUAN) Jan 1, 2018 - Nov 30, 2021
    NIH
    MicroRNA-10a in Airway Smooth Muscle and Asthma
    Role: Co-Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.